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Respiratory Distress in Children with Pneumonia

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1. Efficacy and safety of pulmonary application of corticosteroids in preterm infants with respiratory distress syndrome: a systematic review and meta-analysis Full Text available with Trip Pro

Efficacy and safety of pulmonary application of corticosteroids in preterm infants with respiratory distress syndrome: a systematic review and meta-analysis Systemic corticosteroids as the frontline treatment of respiratory distress syndrome (RDS) in preterm infants are associated with adverse effects on growth and neurodevelopmental outcome, but the pulmonary administration of steroids may help prevent the development of bronchopulmonary dysplasia (BPD) without these side effects.To evaluate (...) , placebo or no other intervention in preterm infants with RDS.We identified 873 potential citations and included 12 unique RCTs. Pulmonary corticosteroid therapy was associated with a significant reduction in the composite outcome of BPD or death (relative risk (RR) 0.85, 95% CI 0.76 to 0.96). Pulmonary application of corticosteroids significantly reduced the incidence of patent ductus arteriosus (PDA) (RR 0.82, 95% CI 0.74 to 0.92) and pneumonia (RR 0.57, 95% CI 0.35 to 0.92). There was no evidence

2018 EvidenceUpdates

2. [Comparison of clinical efficacy of two noninvasive respiratory support therapies for respiratory distress syndrome in very low birth weight preterm infants]. (Abstract)

[Comparison of clinical efficacy of two noninvasive respiratory support therapies for respiratory distress syndrome in very low birth weight preterm infants]. To compare the clinical efficacy of nasal intermittent positive pressure ventilation (NIPPV) and heated humidified high flow nasal cannula (HHHFNC) in the treatment of respiratory distress syndrome (RDS) among very low birth weight (VLBW) preterm infants.A total of 89 very low birth weight premature infants with respiratory distress (...) -invasive mechanical ventilation, duration of oxygen therapy, and incidence rates of severe apnea and pneumonia (P>0.05). There were also no significant differences in the incidence rates of bronchopulmonary dysplasia, necrotizing enterocolitis, retinopathy of prematurity, patent ductus arteriosus, intracranial hemorrhage, and air leak between the two group (P>0.05). The incidence rate of nose injury in the NIPPV group was higher than that in the HHHFNC group (P<0.05).As an initial respiratory support

2018 Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

3. Respiratory Distress in Children with Pneumonia

Respiratory Distress in Children with Pneumonia Respiratory Distress in Children with Pneumonia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer (...) Administration 4 Respiratory Distress in Children with Pneumonia Respiratory Distress in Children with Pneumonia Aka: Respiratory Distress in Children with Pneumonia , Pediatric Respiratory Distress in Pneumonia , Pneumonia Related Respiratory Distress in Children II. Indications severity evaluation in children Directs disposition (Inpatient, PICU) III. Signs: Respiratory Distress in Pneumonia See for age-related criteria Apnea Increased work of breathing Retractions Suprasternal retractions (neck

2018 FP Notebook

4. A shared protocol for porcine surfactant use in pediatric acute respiratory distress syndrome: a feasibility study. Full Text available with Trip Pro

A shared protocol for porcine surfactant use in pediatric acute respiratory distress syndrome: a feasibility study. Pediatric ARDS still represents a difficult challenge in Pediatric Intensive Care Units (PICU). Among different treatments proposed, exogenous surfactant showed conflicting results. Aim of this multicenter retrospective observational study was to evaluate whether poractant alfa use in pediatric ARDS might improve gas exchange in children less than 2 years old, according (...) Distress Syndrome treated with exogenous porcine surfactant were enrolled. Data collection consisted of patient demographics, respiratory variables and arterial blood gas analysis. The most frequent reasons for PICU admission were acute respiratory failure, mainly bronchiolitis and pneumonia, and septic shock. Fifty-four children (78.3%) had severe ARDS (define by oxygen arterial pressure and inspired oxygen fraction ratio (P/F) < 100), 15 (21.7%) had moderate ARDS (100 < P/F < 200). PO2, P/F

2019 BMC Pediatrics

5. Point-of-care lung ultrasound in children with non-cardiac respiratory distress or tachypnea. (Abstract)

Point-of-care lung ultrasound in children with non-cardiac respiratory distress or tachypnea. The purpose of this study was to evaluate the feasibility and diagnostic benefit of point-of-care ultrasound (PoCLUS) in children with non-cardiac respiratory distress or tachypnea.In this prospective observational study, children aged between 1 month and 18 years with respiratory distress, tachypnea, or both, at triage were included. Concordance and accuracy of the emergency department (ED (...) ) and ultrasound diagnoses, length of stay, and time elapsing until ED and ultrasound diagnoses were calculated.One hundred forty-five patients were evaluated. The mean age of the children in the study was 67 ± 58 months. Seventy-nine patients (56%) were boys. Mean length of stay in the ED was 124.6 ± 76.5 min. Mean time to ultrasound diagnosis was 29.32 ± 15.71 min, compared to 46.75 ± 32.65 min for ED diagnosis, which was significantly longer (p < 0.001). Concordance between ultrasound and ED diagnoses

2019 American Journal of Emergency Medicine

6. Clinical Profile and Predictors of Outcome of Pediatric Acute Respiratory Distress Syndrome in a PICU: A Prospective Observational Study. (Abstract)

respiratory distress syndrome (as per Pediatric Acute Lung Injury Consensus Conference definition) from August 1, 2015, to November 2016.None.Out of 1,215 children admitted to PICU, 124 (11.4%) had pediatric acute respiratory distress syndrome. Fifty-six children (45.2%) died. Median age was 2.75 years (1.0-6.0 yr) and 66.9% were male. Most common primary etiologies were pneumonia, severe sepsis, and scrub typhus. Ninety-seven children (78.2%) were invasively ventilated. On multiple logistic regressions (...) Clinical Profile and Predictors of Outcome of Pediatric Acute Respiratory Distress Syndrome in a PICU: A Prospective Observational Study. To study the clinical profile, predictors of mortality, and outcomes of pediatric acute respiratory distress syndrome.A prospective observational study.PICU, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.All children (age > 1 mo to < 14 yr) admitted in PICU with a diagnosis of pediatric acute

2019 Pediatric Critical Care Medicine

7. Specific Viral Etiologies Are Associated With Outcomes in Pediatric Acute Respiratory Distress Syndrome. (Abstract)

pneumonia subjects with and without viruses. Secondarily, we examined the association between specific viruses and outcomes.We performed a secondary analysis of a prospectively enrolled pediatric acute respiratory distress syndrome cohort. Subjects with pneumonia acute respiratory distress syndrome underwent testing of respiratory secretions for viruses and culture for bacteria and fungi and were stratified according to presence or absence of a virus.Tertiary care children's hospital.Children with acute (...) Specific Viral Etiologies Are Associated With Outcomes in Pediatric Acute Respiratory Distress Syndrome. Infectious pneumonia is the most common cause of acute respiratory distress syndrome, with viruses frequently implicated as causative. However, the significance of viruses in pediatric acute respiratory distress syndrome is unknown. We aimed to characterize the epidemiology of viral pneumonia in pediatric acute respiratory distress syndrome and compare characteristics and outcomes between

2019 Pediatric Critical Care Medicine

8. Mycoplasma pneumoniae Community-Acquired Respiratory Distress Syndrome Toxin Uses a Novel KELED Sequence for Retrograde Transport and Subsequent Cytotoxicity Full Text available with Trip Pro

cause of bacterial community-acquired pneumonia (CAP) among children and adults in the United States, synthesizes a 591-amino-acid ADP-ribosylating and vacuolating protein, designated community-acquired respiratory distress syndrome (CARDS) toxin. CARDS toxin alone is sufficient to induce and mimic major inflammatory and histopathological phenotypes associated with M. pneumoniae infection in rodents and primates. In order to elicit its ADP-ribosylating and vacuolating activities, CARDS toxin must (...) Mycoplasma pneumoniae Community-Acquired Respiratory Distress Syndrome Toxin Uses a Novel KELED Sequence for Retrograde Transport and Subsequent Cytotoxicity Mycoplasma pneumoniae is an atypical bacterium that causes respiratory illnesses in humans, including pharyngitis, tracheobronchitis, and community-acquired pneumonia (CAP). It has also been directly linked to reactive airway disease, asthma, and extrapulmonary pathologies. During its colonization, M. pneumoniae expresses a unique ADP

2018 mBio

9. Pediatric trauma-associated acute respiratory distress syndrome: Incidence, risk factors, and outcomes. (Abstract)

Pediatric trauma-associated acute respiratory distress syndrome: Incidence, risk factors, and outcomes. Acute Respiratory Distress Syndrome (ARDS) results in significant morbidity and mortality in pediatric trauma victims. The objective of this study was to determine risk factors and outcomes specifically related to pediatric trauma-associated ARDS (PT-ARDS).A retrospective cohort (2007-2014) of children ≤18 years old from the American College of Surgeons National Trauma Data Bank (NTDB (...) ) was used to analyze incidence, risk factors, and outcomes related to PT-ARDS.PT-ARDS was identified in 0.5% (2660/488,381) of the analysis cohort, with an associated mortality of 18.6% (494/2660). Mortality in patients with PT-ARDS most commonly occurred in the first week after injury. Risk factors associated with the development of PTARDS included nonaccidental trauma, near drowning, severe injury (AIS ≥ 3) to the head or chest, pneumonia, sepsis, thoracotomy, laparotomy, transfusion, and total

2018 Journal of Pediatric Surgery

10. Differences Between Pulmonary and Extrapulmonary Pediatric Acute Respiratory Distress Syndrome: A Multicenter Analysis. (Abstract)

distress syndrome and pulmonary pediatric acute respiratory distress syndrome were sepsis (82.9%) and pneumonia (91.7%), respectively. Children with extrapulmonary pediatric acute respiratory distress syndrome were older, had higher admission severity scores, and had a greater proportion of organ dysfunction compared with pulmonary pediatric acute respiratory distress syndrome group. Patients in the extrapulmonary pediatric acute respiratory distress syndrome group had higher mortality (48.8% vs 24.8 (...) multidisciplinary PICUs in Asia.Mechanically ventilated children meeting the Pediatric Acute Lung Injury Consensus Conference criteria for pediatric acute respiratory distress syndrome between 2009 and 2015.None.Forty-one of 307 patients (13.4%) and 266 of 307 patients (86.6%) were classified into extrapulmonary pediatric acute respiratory distress syndrome and pulmonary pediatric acute respiratory distress syndrome groups, respectively. The most common causes for extrapulmonary pediatric acute respiratory

2018 Pediatric Critical Care Medicine

11. The Association Between Inhaled Nitric Oxide Treatment and ICU Mortality and 28-Day Ventilator-Free Days in Pediatric Acute Respiratory Distress Syndrome. Full Text available with Trip Pro

acute respiratory distress syndrome.None.There were 499 children enrolled in this study with 143 (28.7%) receiving inhaled nitric oxide treatment. Children treated with inhaled nitric oxide were more likely to have a primary diagnosis of pneumonia (72% vs 54.8%; p < 0.001), had a higher initial oxygenation index (median 16.9 [interquartile range, 10.1-27.3] vs 8.5 [interquartile range, 5.8-12.2]; p < 0.001), and had a higher 72-hour maximal Vasoactive-Inotrope Score (median 15 [interquartile range (...) stratified by oxygenation response, inhaled nitric oxide treatment was not associated with mortality or 28-day ventilator-free days in children with a positive oxygenation response (all p > 0.2) CONCLUSIONS:: Treatment with inhaled nitric oxide in pediatric acute respiratory distress syndrome is not associated with improvement in either mortality or ventilator-free days and may be associated with harm. Further prospective trials are required to define the role of inhaled nitric oxide treatment

2018 Critical Care Medicine

12. PECO Air Purification in Hospital Rooms to Improve Health Outcomes for Pediatric Respiratory Distress

purifying units. The main outcomes are the length of stay and progression to ICU, which will be compared with historical controls. Condition or disease Intervention/treatment Phase Asthma Pneumonia Respiratory Distress Syndrome Device: Photo Electrochemical Oxidation (PECO) for Air Purification Not Applicable Detailed Description: The goal of this study is to assess whether using PECO to purify air in a hospital can improve health outcomes for pediatric patients with respiratory distress. The results (...) doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 1 Year to 17 Years (Child) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: All pediatric patients who are admitted to the Mercyhealth Hospital - Rockton Avenue following the Start Date and have infectious or non-infectious respiratory distress as defined by the following ICD codes

2018 Clinical Trials

13. Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome

Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome AMERICANTHORACICSOCIETY DOCUMENTS AnOf?cialAmericanThoracicSociety/EuropeanSocietyofIntensive CareMedicine/SocietyofCriticalCareMedicineClinicalPractice Guideline:MechanicalVentilationinAdultPatientswithAcute RespiratoryDistressSyndrome Eddy Fan, Lorenzo Del Sorbo, Ewan C. Goligher, Carol L. Hodgson, Laveena Munshi, Allan J. Walkey, Neill K. J. Adhikari, Marcelo B. P. Amato, Richard Branson, Roy G. Brower, Niall D (...) , M5G 2N2 Canada. E-mail: eddy.fan@uhn.ca Am J Respir Crit Care Med Vol 195, Iss 9, pp 1253–1263, May 1, 2017 Copyright© 2017 by the American Thoracic Society DOI: 10.1164/rccm.201703-0548ST Internet address: www.atsjournals.org American Thoracic Society Documents 1253 Overview The purpose of this guideline is to analyze evidenceontheuseofventilatorystrategies and associated cointerventions in adult patients with acute respiratory distress syndrome (ARDS) and to provide treatment recommendations

2017 Society of Critical Care Medicine

14. CRACKCast E168 – Pediatric Respiratory Emergencies: Upper Airway Obstruction and Infections

. It is usually a disease of infants and toddlers because the lymphatic chains are prominent in the young and atrophy before puberty. Approximately 50% of pediatric cases occur in children 6 to 12 months of age, most occur before 3 years of age , and 96% of all diagnosed pediatric retropharyngeal abscesses are seen before 6 years of age. Clinical presentation: Fever Sore throat Neck stiffness or nuchal rigidity Torticollis Tismus Neck swelling Drooling Stridor, and muffled voice. **look for the child who has (...) ), poor response to usual treatment of croup (eg, steroids, aerosolized epinephrine), and inspiratory and expiratory stridor. Labs = not helpful. Blood cultures = usually negative. Call ENT and get them to the OR. “Endoscopic tracheal débridement may result in significant clinical improvement and allow the child to be managed without intubation. Serial endoscopy may be needed to manage secretions. Endotracheal intubation is required in children with respiratory distress and hypoxia.” “Patients should

2018 CandiEM

15. CRACKCast E169 – Paediatric Respiratory Emergencies: Lower Airway Obstruction

airway resistance and a compliant chest wall predispose infants to tachypnea, increased work of breathing, and increased oxygen consumption. As a result, the infant with respiratory distress may rapidly develop hypoxemia, bradycardia, and cardiopulmonary arrest.” – Rosen’s 9 th These kids: Are dependent on diaphragm movement for oxygen/ventilation Depend on a fast RR Consume much more O2 and glucose than adults Core questions [1] Excluding asthma, list 8 causes of wheeze “palpation of the chest (...) CRACKCast E169 – Paediatric Respiratory Emergencies: Lower Airway Obstruction CRACKCast E169 - Paediatric Respiratory Emergencies: Lower Airway Obstruction - CanadiEM CRACKCast E169 – Paediatric Respiratory Emergencies: Lower Airway Obstruction In , , by Adam Thomas April 12, 2018 This episode of CRACKCast covers Rosen’s Chapter 168 (9th Ed.). Respiratory presentations are very common in kids, and you will be a pro at managing lower respiratory obstruction after listening to this episode

2018 CandiEM

16. CRACKCast E170 – Paediatric Respiratory Emergencies: Disease of the Lungs

CRACKCast E170 – Paediatric Respiratory Emergencies: Disease of the Lungs CRACKCast E170 - Paediatric Respiratory Emergencies: Disease of the Lungs - CanadiEM CRACKCast E170 – Paediatric Respiratory Emergencies: Disease of the Lungs In by Adam Thomas April 16, 2018 This episode of CRACKCast covers Rosen’s Chapter 170, Pediatric Respiratory Emergencies: Diseases of the Lungs. This chapter covers specific diseases of the pediatric lung, including pneumonia, pertussis and cystic fibrosis (...) and bacterial pneumonia. A CBC should not be obtained unless the results will change management. A venous or arterial blood gas study is not needed in most patients, but may be considered in a child with severe respiratory distress to monitor the effectiveness of respiratory status or ventilation with therapy. In a well-appearing child with an uncomplicated pneumonia, a blood culture is unlikely to be helpful and should not be obtained. Blood cultures should only be considered in ill-appearing hospitalized

2018 CandiEM

17. Ewings Sarcoma: A Case of Respiratory Distress and Opacification That was not Pneumonia. (Abstract)

Ewings Sarcoma: A Case of Respiratory Distress and Opacification That was not Pneumonia. The Ewing sarcoma family of tumors typically appears in the second decade of life with regional pain and swelling of a long bone. The following case presents a pediatric patient, aged 4 years, given a diagnosis of Ewing sarcoma of the rib with the initial presentation of respiratory distress, hypoxia, and pleural effusion. Respiratory distress accounts for a large majority of emergency department visits

2017 Pediatric Emergency Care

18. Risk Stratification in Pediatric Acute Respiratory Distress Syndrome: A Multicenter Observational Study. (Abstract)

Risk Stratification in Pediatric Acute Respiratory Distress Syndrome: A Multicenter Observational Study. The Pediatric Acute Lung Injury Consensus Conference developed a pediatric specific definition for acute respiratory distress syndrome (PARDS). In this definition, severity of lung disease is stratified into mild, moderate, and severe groups. We aim to describe the epidemiology of patients with PARDS across Asia and evaluate whether the Pediatric Acute Lung Injury Consensus Conference risk (...) stratification accurately predicts outcome in PARDS.A multicenter, retrospective, descriptive cohort study.Ten multidisciplinary PICUs in Asia.All mechanically ventilated children meeting the Pediatric Acute Lung Injury Consensus Conference criteria for PARDS between 2009 and 2015.None.Data on epidemiology, ventilation, adjunct therapies, and clinical outcomes were collected. Patients were followed for 100 days post diagnosis of PARDS. A total of 373 patients were included. There were 89 (23.9%), 149 (39.9

2017 Critical Care Medicine

19. Nasal High Frequency Oscillation for Respiratory Distress Syndrome in Twins Infants

Nasal High Frequency Oscillation for Respiratory Distress Syndrome in Twins Infants Nasal High Frequency Oscillation for Respiratory Distress Syndrome in Twins Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Nasal High Frequency Oscillation for Respiratory Distress Syndrome in Twins Infants The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03206489 Recruitment Status : Recruiting First Posted : July 2, 2017 Last

2017 Clinical Trials

20. Bi-level Positive Airway Pressure for Respiratory Distress Syndrome in Twins Infants

. Respiratory distress syndrome Silverman score >5; 4. Informed parental consent has been obtained. Exclusion Criteria: 1. Severe respiratory distress syndrome requiring early intubation according to the American Academy of Pediatrics guidelines for neonatal resuscitation; 2. Major congenital malformations or complex congenital heart disease; 3. Group B hemolytic streptococcus pneumonia, septicemia, pneumothorax, pulmonary hemorrhage; 4. Cardiopulmonary arrest needing prolonged resuscitation; 5. transferred (...) Bi-level Positive Airway Pressure for Respiratory Distress Syndrome in Twins Infants Bi-level Positive Airway Pressure for Respiratory Distress Syndrome in Twins Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2017 Clinical Trials

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