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Renin-Angiotensin System

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141. Renin-angiotensin system gene polymorphisms and high blood pressure in Lithuanian children and adolescents. Full Text available with Trip Pro

Renin-angiotensin system gene polymorphisms and high blood pressure in Lithuanian children and adolescents. Epidemiological studies have demonstrated the influence of environmental factors on HBP in the population of Lithuanian children, although the role of genetic factors in hypertension has not yet been studied. The aim of this study was to assess the distribution of AGTR1, AGT, and ACE genotypes in the Lithuanian child population and to determine whether these genotypes have an impact

2017 BMC Medical Genetics

142. Impact of Renin-Angiotensin Aldosterone System Inhibition on Serum Potassium Levels among Peritoneal Dialysis Patients. Full Text available with Trip Pro

Impact of Renin-Angiotensin Aldosterone System Inhibition on Serum Potassium Levels among Peritoneal Dialysis Patients. The chronic use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blocker has been associated with hyperkalemia in patients with reduced renal function even after the initiation of hemodialysis. Whether such medications may cause a similar effect in peritoneal dialysis patients is not well established. So, the aim of our study was to analyze the impact (...) to patients using, respectively, an ACEi or ARB and then got the drug suspended; Groups II and IV started peritoneal dialysis without the use of any renin-angiotensin aldosterone system inhibitor and then got, respectively, an ACEi or ARB introduced. Changes in potassium serum levels were compared using 2 statistical approaches: (1) the non-parametric Wilcoxon test for repeated measures and (2) a crossover analysis.Mean potassium serum levels at the first phase of the study for Groups I, II, III, and IV

2017 American journal of nephrology

143. Renin-Angiotensin System Blockers and Statins Are Associated With Lower In-Hospital Mortality in Very Elderly Hypertensives. (Abstract)

Renin-Angiotensin System Blockers and Statins Are Associated With Lower In-Hospital Mortality in Very Elderly Hypertensives. Cardiovascular diseases are mainly related to hypertension and dyslipidemia and increase with aging because of the larger time span for these risk factors to damage arterial blood vessels. The impact of cardiovascular drug therapy on outcomes in the very elderly hospitalized is still not well established. The aim of our study was to evaluate the associations between (...) blockers and statins, through their beneficial effects on the cardiovascular system, have a positive impact on survival in very elderly hospitalized patients. Our data confirm the important role of such drugs even in this particular population with a mean age higher than 88 years, where scientific evidence is still scanty.Copyright © 2017 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.

2017 Journal of the American Medical Directors Association

144. Biochemical monitoring after initiation of aldosterone antagonist therapy in users of renin-angiotensin system blockers: a UK primary care cohort study. Full Text available with Trip Pro

Biochemical monitoring after initiation of aldosterone antagonist therapy in users of renin-angiotensin system blockers: a UK primary care cohort study. To determine the frequency of biochemical monitoring after initiation of aldosterone antagonists(AA) in patients also using angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB).UK primary care.ACEI/ARB users who initiated AA between 2004 and 2014.We calculated the proportions with: (1) biochemical monitoring ≤2

2017 BMJ open

145. Association between renin-angiotensin-aldosterone system blockade and future osteoporotic fracture risk in hypertensive population: A population-based cohort study in Taiwan. Full Text available with Trip Pro

Association between renin-angiotensin-aldosterone system blockade and future osteoporotic fracture risk in hypertensive population: A population-based cohort study in Taiwan. Tissue renin-angiotensin-aldosterone system (RAAS) activation in sites of osteoporosis had been demonstrated in animal studies; however, the possibility of RAAS blockade to prevent future osteoporotic fracture had rarely been verified in clinical studies. We Used the Taiwan Longitudinal Health insurance database 2000

2017 Medicine

146. Relation Between Renin-Angiotensin System Blockers and Survival Following Isolated Aortic Valve Replacement for Aortic Stenosis. (Abstract)

Relation Between Renin-Angiotensin System Blockers and Survival Following Isolated Aortic Valve Replacement for Aortic Stenosis. Renin-angiotensin system blockers (RASb) improve cardiac remodeling, but their clinical utility after surgical aortic valve replacement (SAVR) for aortic stenosis (AS) is unclear. We aimed to assess the impact of RASb on short- and long-term survival following isolated SAVR for severe AS. From January 2005 to January 2014, 508 consecutive patients had isolated SAVR

2017 American Journal of Cardiology

147. Renin-angiotensin system blockade promotes a cardio-renal protection in albuminuric homozygous sickle cell patients. Full Text available with Trip Pro

Renin-angiotensin system blockade promotes a cardio-renal protection in albuminuric homozygous sickle cell patients. The management of sickle cell nephropathy (SCN) at an early stage is an important issue to prevent renal and cardiovascular morbidity and mortality. This study aimed to evaluate in this population, whether angiotensin converting enzyme inhibitors (ACEIs) treatment could exert a cardio-renal protection in a SCN cohort. Forty-two SCN patients (urine albumin:creatinine ratio (ACR

2017 British journal of haematology

148. Long-term mortality benefit of renin-angiotensin system inhibitors in patients with chronic limb-threatening ischemia undergoing vascular intervention. Full Text available with Trip Pro

Long-term mortality benefit of renin-angiotensin system inhibitors in patients with chronic limb-threatening ischemia undergoing vascular intervention. The beneficial effect of renin-angiotensin system (RAS) inhibitors has been well-established in patients with cardiovascular disease; however, their effectiveness in patients with chronic limb-threatening ischemia (CLTI), a selected disease-burdened population, is largely unknown. The purpose of this study was to evaluate long-term outcomes

2017 Journal of Vascular Surgery

149. Renin-angiotensin system blockade therapy after transcatheter aortic valve implantation. (Abstract)

Renin-angiotensin system blockade therapy after transcatheter aortic valve implantation. The persistence of left ventricular (LV) hypertrophy is associated with poor clinical outcomes after transcatheter aortic valve implantation (TAVI) for aortic stenosis. However, the optimal medical therapy after TAVI remains unknown. We investigated the effect of renin-angiotensin system (RAS) blockade therapy on LV hypertrophy and mortality in patients undergoing TAVI.Between October 2013 and April 2016

2017 Heart

150. Attenuation of Accelerated Renal Cystogenesis in Pkd1 Mice by Renin Angiotensin System Blockade. Full Text available with Trip Pro

Attenuation of Accelerated Renal Cystogenesis in Pkd1 Mice by Renin Angiotensin System Blockade. The intrarenal renin angiotensin system (RAS) is activated in polycystic kidney disease. We have recently shown in the Pkd1 mouse that Gen 2 antisense oligonucleotide (ASO), which suppresses angiotensinogen (Agt) synthesis, is efficacious in slowing kidney cyst formation compared with lisinopril. The aim of this current study was to determine 1) if unilateral nephrectomy accelerates cystogenesis

2017 American Journal of Physiology. Renal physiology

151. Evaluation of Vasopressin for Septic Shock in Patients on Chronic Renin-Angiotensin-Aldosterone System Inhibitors. (Abstract)

Evaluation of Vasopressin for Septic Shock in Patients on Chronic Renin-Angiotensin-Aldosterone System Inhibitors. To compare the hemodynamic response in septic shock patients receiving vasopressin who were on chronic renin-angiotensin-aldosterone system inhibitor therapy with those who were not.Single-center, retrospective cohort study.Medical and surgical ICUs at a 1,100-bed academic medical center.Medical and surgical ICU patients with septic shock who received vasopressin infusion added (...) to at least one concomitant vasopressor agent between January 2014 and December 2015, then divided into two cohorts: 1) patients who were on chronic renin-angiotensin-aldosterone system inhibitor therapy as outpatients and 2) patients who were not on chronic renin-angiotensin-aldosterone system inhibitor therapy as outpatients.None.Mean arterial pressure at 6 hours was 72.2 mm Hg in the renin-angiotensin-aldosterone system inhibitor group versus 69.7 mm Hg in the non-renin-angiotensin-aldosterone system

2017 Critical Care Medicine

152. The use of drugs acting on the renin-angiotensin system and the incidence of pancreatic cancer. Full Text available with Trip Pro

The use of drugs acting on the renin-angiotensin system and the incidence of pancreatic cancer. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used antihypertensives. Recently, these drugs have been associated with a protective effect against pancreatic cancer, but data on this putative association remain limited. Thus, the objective of this study was to determine whether the use of ACEIs and/or ARBs is associated with a decreased risk

2017 British Journal of Cancer

153. Family history and renin-angiotensin system gene polymorphisms in Chinese patients with type 2 diabetes mellitus. Full Text available with Trip Pro

Family history and renin-angiotensin system gene polymorphisms in Chinese patients with type 2 diabetes mellitus. A positive family history is recognized as an important risk factor for type 2 diabetes mellitus (T2DM), but the association of family history with rennin-angiotensin system (RAS) gene polymorphisms has not been reported yet, thus we aim to investigate it.Family history records, clinical and biochemical data were obtained from 1239 T2DM patients. Polymerase chain reaction (PCR

2017 Medicine

154. Impact of Renin-Angiotensin System Inhibitors Continuation on Outcome After Major Surgery

Impact of Renin-Angiotensin System Inhibitors Continuation on Outcome After Major Surgery Impact of Renin-Angiotensin System Inhibitors Continuation on Outcome After Major Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Impact of Renin-Angiotensin System Inhibitors Continuation on Outcome After Major Surgery (STOPorNOT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03374449 Recruitment Status : Recruiting

2017 Clinical Trials

155. Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin-angiotensin system. (Abstract)

Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin-angiotensin system. Butyrate, a short-chain fatty acid, is the end product of the fermentation of complex carbohydrates by the gut microbiota. Recently, sodium butyrate (NaBu) has been found to play a protective role in a number of chronic diseases. However, it is still unclear whether NaBu has a therapeutic potential in hypertension. The present study was aimed (...) increased by Ang II infusion but decreased by NaBu treatment. In cultured innermedullary collecting duct cells, NaBu treatment attenuated Ang II-induced expression of PRR and renin.These results demonstrate that NaBu exerts an antihypertensive action, likely by suppressing the PRR-mediated intrarenal renin-angiotensin system.

2017 Journal of Hypertension

156. Renin angiotensin aldosterone system altered in resistant hypertension in Sub-Saharan African diabetes patients without evidence of primary hyperaldosteronism Full Text available with Trip Pro

Renin angiotensin aldosterone system altered in resistant hypertension in Sub-Saharan African diabetes patients without evidence of primary hyperaldosteronism The renin-angiotensin-aldosterone system may be altered in patients with resistant hypertension. This study aimed to evaluate the relation between renin-angiotensin-aldosterone system activity and resistant hypertension in Cameroonian diabetes patients with resistant hypertension.We carried out a case-control study including 19 diabetes (...) patients with resistant hypertension and 19 diabetes patients with controlled hypertension matched to cases according to age, sex and duration of hypertension since diagnosis. After collection of data, fasting blood was collected for measurement of sodium, potassium, chloride, active renin and plasma aldosterone of which the aldosterone-renin ratio was derived to assess the activity of renin-angiotensin-aldosterone system. Then, each participant received 2000 ml infusion of saline solution after which

2017 JRSM cardiovascular disease

157. Comparative Analysis of Renin-Angiotensin System (RAS)-Related Gene Expression Between Hypertensive and Normotensive Rats Full Text available with Trip Pro

Comparative Analysis of Renin-Angiotensin System (RAS)-Related Gene Expression Between Hypertensive and Normotensive Rats BACKGROUND The renal renin-angiotensin system (RAS) is physiologically important for blood pressure regulation. Altered regulation of RAS-related genes has been observed in an animal model of hypertension (spontaneously hypertensive rats - SHRs). The current understanding of certain RAS-related gene expression differences between Wistar-Kyoto rats (WKYs) and SHRs is either

2017 Medical science monitor basic research

158. Renin-Angiotensin System Blockade Improves Cardiac Indices in Acromegaly Patients Full Text available with Trip Pro

Renin-Angiotensin System Blockade Improves Cardiac Indices in Acromegaly Patients Blockade of the angiotensin-renin system, with angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs), has been shown to improve cardiac outcomes following myocardial infarction and delay progression of heart failure. Acromegaly is associated with a disease-specific cardiomyopathy, the pathogenesis of which is poorly understood.The cardiac indices of patients with active

2017 Experimental and Clinical Endocrinology & Diabetes

159. Association of seven renin angiotensin system gene polymorphisms with restenosis in patients following coronary stenting Full Text available with Trip Pro

Association of seven renin angiotensin system gene polymorphisms with restenosis in patients following coronary stenting Percutaneous coronary intervention, despite being effective for coronary revascularization, causes in-stent restenosis due to neointimal hyperplasia in a large number of patients. The renin-angiotensin system is involved in neointimal hyperplasia. This study sought to evaluate seven gene polymorphisms of key renin-angiotensin system components, including angiotensinogen

2017 Journal of the Renin-Angiotensin-Aldosterone System: JRAAS

160. Intrarenal renin-angiotensin system activation in end-stage renal disease Full Text available with Trip Pro

Intrarenal renin-angiotensin system activation in end-stage renal disease 28179627 2018 07 30 2018 12 02 1348-4214 40 4 2017 04 Hypertension research : official journal of the Japanese Society of Hypertension Hypertens. Res. Intrarenal renin-angiotensin system activation in end-stage renal disease. 351-352 10.1038/hr.2017.7 Urushihara Maki M Department of Pediatrics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan. Kobori Hiroyuki H Departments (...) of Pharmacology and Nephrology, School of Medicine, International University of Health and Welfare, Tokyo, Japan. eng R01 DK072408 DK NIDDK NIH HHS United States Journal Article Comment 2017 02 09 England Hypertens Res 9307690 0916-9636 11002-13-4 Angiotensinogen 11128-99-7 Angiotensin II EC 3.4.23.15 Renin IM Hypertens Res. 2017 Apr;40(4):364-370 27761002 Angiotensin II Angiotensinogen Humans Kidney Kidney Failure, Chronic Renin Renin-Angiotensin System 2017 2 10 6 0 2018 7 31 6 0 2017 2 10 6 0 ppublish

2017 Hypertension research : official journal of the Japanese Society of Hypertension

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