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Relaxation Technique

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6441. Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum. Full Text available with Trip Pro

Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum. Members of the Plasmodium falciparum var gene family encode clonally variant adhesins, which play an important role in the pathogenicity of tropical malaria. Here we employ a selective panning protocol to generate isogenic P.falciparum populations with defined adhesive phenotypes for CD36, ICAM-1 and CSA, expressing single (...) and distinct var gene variants. This technique has established the framework for examining var gene expression, its regulation and switching. It was found that var gene switching occurs in situ. Ubiquitous transcription of all var gene variants appears to occur in early ring stages. However, var gene expression is tightly regulated in trophozoites and is exerted through a silencing mechanism. Transcriptional control is mutually exclusive in parasites that express defined adhesive phenotypes. In situ var

1998 The EMBO journal

6442. Reversible impairment of endothelium-dependent relaxation in golden hamster carotid arteries during hibernation Full Text available with Trip Pro

Reversible impairment of endothelium-dependent relaxation in golden hamster carotid arteries during hibernation The effects of hibernation on endothelium-dependent vasodilatation were investigated in the golden hamster carotid artery, paying special attention to hibernating body temperature (10 degrees C). To record mechanical and electrical membrane responses, we applied pharmacological (organ bath) and electrophysiological (microelectrode) techniques, using acetylcholine (ACh; 0.001-100 (...) microM) and ATP (0.01-1000 microM) for endothelium-dependent vasodilatation and sodium nitroprusside (SNP; 0.05-10 microM) for endothelium-independent vasodilatation. At 34 degrees C, ACh, ATP and SNP each induced a relaxation or a hyperpolarization, and these responses were similar in all the preparations from control and hibernated animals. At 10 degrees C, on the other hand, ACh-induced relaxations and hyperpolarizations were reduced to approximately 35 % and 50 % of the euthermic level

2002 The Journal of physiology

6443. Proton relaxation times and interstitial fluid pressure in human melanoma xenografts. Full Text available with Trip Pro

Proton relaxation times and interstitial fluid pressure in human melanoma xenografts. The interstitial fluid pressure (IFP) and the proton spin-lattice and spin-spin relaxation times (T1 and T2) of some experimental tumours have been shown to be related to tumour water content. These observations have led to the hypothesis that magnetic resonance imaging (MRI) might be a clinically useful non-invasive method for assessment of tumour IFP. The purpose of the work reported here was to examine (...) the general validity of this hypothesis. R-18 human melanoma xenografts grown intradermally in Balb/c nu/nu mice were used as the tumour model system. Median T1 and T2 were determined by spin-echo MRI using a 1.5-T clinical whole-body tomograph. IFP was measured using the wick-in-needle technique. No correlation was found between tumour IFP and fractional tumour water content. Moreover, there was no correlation between median T1 or T2 and IFP, suggesting that proton T1 and T2 values determined by MRI

1997 British journal of cancer

6444. Home Based Massage and Relaxation for Sickle Cell Pain

. Glenview, IL: American Pain Society. Layout table for additonal information ClinicalTrials.gov Identifier: Other Study ID Numbers: First Posted: August 5, 2003 Last Update Posted: August 6, 2008 Last Verified: August 2008 Keywords provided by National Center for Complementary and Integrative Health (NCCIH): Sickle Cell Pain Sickle Cell Disease Chronic Pain Alternative Medicine/Therapy Complementary Medicine Massage Therapy Relaxation Technique Home-based Therapy Additional relevant MeSH terms: Layout (...) Home Based Massage and Relaxation for Sickle Cell Pain Home Based Massage and Relaxation for Sickle Cell Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Home Based Massage and Relaxation for Sickle

2003 Clinical Trials

6445. Relaxation Response Training for the Treatment of Rheumatoid Arthritis

Rheumatoid Arthritis Behavioral: Relaxation response and cognitive behavioral therapy Behavioral: Relaxation response Other: RA education Phase 4 Detailed Description: RR training is a part of most multi-component psychosocial therapies for RA. RR training may decrease perceived psychosocial stress and autonomic tone, which in turn diminishes pain and the anticipatory anxiety associated with pain. RR training involves learning relaxation techniques which include diaphragmatic breathing, progressive (...) skeletal muscle relaxation, and the induction of a state of focused attention on a chosen word, phrase, or image. In clinical practice, RR training is generally administered as one component of RA therapy. In this study, the effectiveness of RR training will be evaluated when RR training is administered alone and in combination with a cognitive behavioral therapy program. The cognitive behavior techniques include problem solving, relabeling, enhanced awareness of pain behaviors, and attention

2003 Clinical Trials

6446. Efficacy and Cost Effectiveness of Relaxation and Response to CHF

to be effective in managing CHF-related conditions. With its favorable physiological changes, the relaxation response is likely to benefit CHF patients. Condition or disease Intervention/treatment Phase Chronic Heart Failure Behavioral: relaxation technique Behavioral: educational program Not Applicable Detailed Description: Background: Despite the development of significant pharmaceutical treatments, morbidity and mortality of chronic heart failure (CHF) patients remain high, patients� quality of life (...) : Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Official Title: Efficacy and Cost Effectiveness of Relaxation and Response to CHF Actual Study Completion Date : September 2003 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Arm 1 Behavioral: relaxation technique Behavioral: educational program Outcome Measures Go to Eligibility Criteria Go to Information from the National Library of Medicine

2001 Clinical Trials

6447. Discrepancies in the measurement of isovolumic relaxation time: a study comparing M mode and Doppler echocardiography. Full Text available with Trip Pro

technique. Possible differences in the measurement of the isovolumic relaxation time were studied when these landmarks were used in 44 healthy people, 14 patients with mitral stenosis, 21 patients with left ventricular hypertrophy, and 24 patients with dilated cardiomyopathy by recording M mode echograms of the mitral valve, and pulsed and continuous wave Doppler spectra of transmitral flow, with simultaneous electrocardiograms and phonocardiograms. A2 was effectively synchronous with the aortic (...) Discrepancies in the measurement of isovolumic relaxation time: a study comparing M mode and Doppler echocardiography. Mitral valve cusp separation on M mode echogram, the mitral valve opening artefact, and the onset of forward transmitral flow recorded by Doppler echocardiography have all been taken to mark the end of isovolumic relaxation, while its onset has been taken either as the aortic closure sound (A2) recorded phonocardiographically or the aortic closure artefact determined by Doppler

1990 British Heart Journal

6448. Inspiratory muscle maximum relaxation rate measured from submaximal sniff nasal pressure in patients with severe COPD Full Text available with Trip Pro

Inspiratory muscle maximum relaxation rate measured from submaximal sniff nasal pressure in patients with severe COPD Slowing of the inspiratory muscle maximum relaxation rate (MRR) is a useful index of severe inspiratory muscle loading and potential fatigue and has been measured from the oesophageal pressure during sniffs in patients with chronic obstructive pulmonary disease (COPD). The purpose of this study was to investigate whether it is possible to measure MRR and detect slowing using (...) returning to baseline values within 5-10 minutes. A separate analysis of the sniff pressures using only the nasal pressure traces demonstrated a similar pattern of slowing and recovery.It is possible to detect slowing of the inspiratory muscles non-invasively using sniff nasal pressures in patients with COPD. This could be a useful technique with which to measure severe and potentially fatiguing inspiratory muscle loading, both in clinical settings and during exercise studies.

2002 Thorax

6449. A COMPARATIVE STUDY OF EFFICACY OF EMG BIO-FEEDBACK AND PROGRESSIVE MUSCULAR RELAXATION IN TENSION HEADACHE Full Text available with Trip Pro

A COMPARATIVE STUDY OF EFFICACY OF EMG BIO-FEEDBACK AND PROGRESSIVE MUSCULAR RELAXATION IN TENSION HEADACHE The aim of the present study was to find out efficacy of frontalis EMG Biofeedback therapy, deep muscular relaxation therapy and compare the efficacy of both in cases of tension headache. During two week basal-data recording period all patients were taught deep muscular relaxation by Jacobson's technique. Simultaneously patients were instructed to keep headache diary. Headache diary (...) lasting 30 minutes. Patients were instructed to practice at least one 30 minute session of relaxation at home. The data were subjected to statistical calculation. The results indicate that frontalis EMG Biofeedback therapy and deep muscle relaxation therapy are significantly effective in cases of tension headache. Both treatments are equally effective. The findings are discussed in relation to Indian situation.

1984 Indian journal of psychiatry Controlled trial quality: uncertain

6450. Hypnosis compared to relaxation in the outpatient management of chronic low back pain. (Abstract)

Hypnosis compared to relaxation in the outpatient management of chronic low back pain. Chronic low back pain (CLBP) presents a problem of massive dimensions. While inpatient approaches have been evaluated, outpatient treatment programs have received relatively little examination. Hypnosis and relaxation are two powerful techniques amenable to outpatient use. Seventeen outpatient subjects suffering from CLBP were assigned to either Self-Hypnosis (n = 9) or Relaxation (n = 8) treatments

1983 Archives of physical medicine and rehabilitation

6451. Effect of relaxation on blood pressure and serum cholesterol. (Abstract)

Effect of relaxation on blood pressure and serum cholesterol. Chronic sympathetic nervous system overactivity has been implicated in the pathogenesis of both hypertension and hypercholesterolemia. We conducted a controlled trial to determine the effect of a relaxation technique on blood pressure and serum cholesterol in drug free subjects with normal and slightly elevated values. Over the follow-up period, highly significant reductions in blood pressure and serum cholesterol levels were noted (...) in relaxation group subjects while control group subjects showed no significant changes. These results suggest that relaxation therapy may contribute to the management of individuals with mild hypertension and/or mild hypercholesterolemia.

1982 Activitas nervosa superior

6452. Increasing breast milk production for premature infants with a relaxation/imagery audiotape. (Abstract)

Increasing breast milk production for premature infants with a relaxation/imagery audiotape. Many women whose premature infants are hospitalized in a newborn intensive care unit choose to express breast milk for their babies. Yet anxiety, fatigue, and emotional stress are powerful inhibitors of lactation. To facilitate the breast-feeding experience, intervention mothers were given a 20-minute audio cassette tape based on relaxation and visual imagery techniques. At a single follow-up expression (...) of milk at the hospital approximately 1 week after enrollment, they expressed 63% more breast milk than a randomized group of control mothers. The fat content of the breast milk in the two groups was not significantly different. Among a small group of mothers whose infants were receiving mechanical ventilation, the increase in milk volume compared with that of control mothers was 121%. Longer-term effects of the relaxation/imagery approach (such as extending the duration of breast-feeding or reducing

1989 Pediatrics

6453. The effects of relaxation training on clinical symptoms: a meta-analysis. (Abstract)

The effects of relaxation training on clinical symptoms: a meta-analysis. Forty-eight experimental studies of nonmechanically assisted relaxation techniques used to control a variety of clinical symptoms were synthesized using meta-analysis. Effect sizes for three types of comparisons, experimental-control, experimental-placebo, and pre-post, ranged from .43 to .66, demonstrating that treatment of any type included in the analysis moved the client from the 50th to the 67th percentile (...) of an untreated group at minimum and from the 50th to the 75th percentile at maximum. All treatments included in the analysis except Benson's relaxation technique demonstrated evidence of effectiveness, particularly for nonsurgical samples with chronic problems such as hypertension, headache, and insomnia.

1989 Nursing research

6454. Relaxation for the relief of chronic pain: a systematic review. (Abstract)

Relaxation for the relief of chronic pain: a systematic review. The effectiveness of relaxation techniques in the management of chronic pain was determined in this systematic review of published randomized controlled trials. Reports were sought by searching MEDLINE, psycLIT, CINAHL, EMBASE and the Oxford Pain Relief Database. Studies were included in this review if they were randomized controlled trials of relaxation techniques in chronic pain. Studies which investigated the effects (...) control groups rather than for relaxation. There is insufficient evidence to confirm that relaxation can reduce chronic pain. Many of the studies both positive and negative suffer methodological inadequacies. Recommendations for future research into the effectiveness of relaxation techniques for chronic pain are made.

1998 Journal of advanced nursing

6455. Relaxation therapies for asthma: a systematic review. Full Text available with Trip Pro

Relaxation therapies for asthma: a systematic review. Emotional stress can either precipitate or exacerbate both acute and chronic asthma. There is a large body of literature available on the use of relaxation techniques for the treatment of asthma symptoms. The aim of this systematic review was to determine if there is any evidence for or against the clinical efficacy of such interventions.Four independent literature searches were performed on Medline, Cochrane Library, CISCOM, and Embase (...) relaxation, two of which showed significant effects of therapy. One RCT investigating hypnotherapy, one of autogenic training, and two of biofeedback techniques revealed no therapeutic effects. Overall, the methodological quality of the studies was poor.There is a lack of evidence for the efficacy of relaxation therapies in the management of asthma. This deficiency is due to the poor methodology of the studies as well as the inherent problems of conducting such trials. There is some evidence

2002 Thorax

6456. Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy. Silicone Study Report 5. The Silicone Study Group. (Abstract)

eyes. We conclude that eyes undergoing a vitreous operation for the first time for the treatment of proliferative vitreoretinopathy can in most instances be successfully treated by conventional techniques without the need for relaxing retinotomy. Retinotomy may be required more often in patients undergoing repeat vitreous surgery for proliferative vitreoretinopathy, in which case both silicone oil and long-acting perflouropropane gas appear to be equally effective. (...) Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy. Silicone Study Report 5. The Silicone Study Group. In the Silicone Study, 117 of 404 eyes (29%) with severe proliferative vitreoretinopathy (> or = C-3, full-thickness retinal folds in three or more quadrants) enrolled in the study were treated with vitrectomy, underwent a relaxing retinotomy, and were randomly assigned to treatment with long-acting gas or silicone oil. Forty-six eyes

1993 American journal of ophthalmology Controlled trial quality: uncertain

6457. The effects of music and muscle relaxation on patient anxiety in a coronary care unit. (Abstract)

The effects of music and muscle relaxation on patient anxiety in a coronary care unit. To test the efficacy of music and muscle relaxation techniques in reducing the anxiety of patients admitted to a coronary care unit with ischemic heart disease.Randomized, controlled trial.Seven-bed coronary care unit of an Australian tertiary care hospital.Fifty-six patients admitted to a coronary care unit with unstable angina pectoris or acute myocardial infarction.Psychologic (State Trait Anxiety (...) . No significant differences (p < 0.05) between groups were demonstrated for the psychologic or physiologic variables; that is, no significant reductions in anxiety were achieved for patients using music or muscle relaxation interventions when compared with the control group. The effect size of the interventions on the outcome measures was 0.19 to 0.22, indicating a small effect. Resultant power was at a low level.These results differ from those of similar studies but may be related to the high probability

1994 Heart & Lung Controlled trial quality: uncertain

6458. Changes in cellular immune function after immune specific guided imagery and relaxation in high and low hypnotizable healthy subjects. (Abstract)

between the results of the limited number of investigations studying the effects of guided imagery and relaxation on immune function. These differences may in part be explained by differences in methodology, time intervals between blood sampling, and subject characteristics such as age, health status and hypnotizability. The inconsistent results make it premature to make inferences about possible benefits of the application of these techniques in the treatment of immune related diseases, and further (...) Changes in cellular immune function after immune specific guided imagery and relaxation in high and low hypnotizable healthy subjects. This article presents the results of two investigations, each measuring cellular immune function on 3 investigation days 1 week apart in 15 high and 15 low hypnotizable healthy subjects randomly selected for three groups: (1) a guided imagery group receiving instructions to enhance cellular immune function: (2) a relaxation group which did not receive

1994 Psychotherapy and Psychosomatics Controlled trial quality: uncertain

6459. The use of relaxation for the promotion of comfort and pain relief in persons with advanced cancer. (Abstract)

The use of relaxation for the promotion of comfort and pain relief in persons with advanced cancer. The efficacy of a relaxation technique involving deep breathing, muscle relaxation, and imagery was tested as a nursing intervention for the promotion of comfort and pain relief in hospitalized oncology patients. The intervention was implemented in accordance with Orem's self-care approach to nursing practice. Sixty-seven new admissions to an oncology ward were randomly assigned to receive (...) relaxation training by audio tapes, live relaxation training by nurses, or no relaxation training. Relaxation training was conducted twice weekly over a period of three weeks. All subjects were pretested and post-tested with the McGill Pain Questionnaire and Visual Analogue Scale for pain. Analgesic medication was monitored throughout the study. Data analysis showed significant reductions in subjective pain ratings by subjects receiving relaxation training. There was also a significant reduction in non

1994 Contemporary nurse Controlled trial quality: uncertain

6460. Labeling relaxation procedures: impact on adolescent's self-report of effectiveness. (Abstract)

Labeling relaxation procedures: impact on adolescent's self-report of effectiveness. Adolescents are being taught relaxation techniques by health-care professionals with increased frequency. The present study examined the effect, on self-reported relaxation, of labeling passive relaxation techniques as "hypnotic relaxation" or as "relaxation training." Subjects were 64 adolescent college students who scored above the 50th percentile, from a subject pool of 189 potential subjects (...) , on the Spielberger Trait Anxiety Inventory. A two by two by two factorial design was utilized with sex, label (hypnotic relaxation versus relaxation training) and relaxation technique (hypnotic induction versus autogenic training) as the independent variables. Under the guise of an investigation of the physiologic correlates of relaxation, subjects were assigned at random to one of four groups. Manipulations of label and relaxation technique were presented on tape via an intercom system. The dependent variable

1992 The Journal of adolescent health : official publication of the Society for Adolescent Medicine Controlled trial quality: uncertain

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