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161. Retrovirus Integration Database (RID): a public database for retroviral insertion sites into host genomes (PubMed)

Retrovirus Integration Database (RID): a public database for retroviral insertion sites into host genomes The NCI Retrovirus Integration Database is a MySql-based relational database created for storing and retrieving comprehensive information about retroviral integration sites, primarily, but not exclusively, HIV-1. The database is accessible to the public for submission or extraction of data originating from experiments aimed at collecting information related to retroviral integration sites (...) including: the site of integration into the host genome, the virus family and subtype, the origin of the sample, gene exons/introns associated with integration, and proviral orientation. Information about the references from which the data were collected is also stored in the database. Tools are built into the website that can be used to map the integration sites to UCSC genome browser, to plot the integration site patterns on a chromosome, and to display provirus LTRs in their inserted genome sequence

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2016 Retrovirology

162. Systematic Review - Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders

Systematic Review - Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders 4 March 2019 Prepared for: Department of Veterans Affairs Veterans Health Administration Health Services Research & Development Service Washington, DC 20420 Prepared by: Evidence Synthesis Program (ESP) Center Portland VA Medical Center Portland, OR Mark Helfand, MD, MPH, MS, Director (...) Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders: A Systematic Review Authors: Principal Investigator: Nancy Greer, PhD Timothy J. Wilt, MD, MPH Co-Investigators: Princess Ackland, PhD, MSPH Roderick MacDonald, MS Nina Sayer, PhD Michele Spoont, PhD Brent Taylor, PhD Research Assistants: Lauren McKenzie, MPH Christina Rosebush, MPH Evidence Synthesis Program 4 Relationship

2019 Veterans Affairs Evidence-based Synthesis Program Reports

163. Management of Cancer Medication-Related Infusion Reactions

Management of Cancer Medication-Related Infusion Reactions Management of Cancer Medication- Related Infusion Reactions Care has been taken in the preparation of the information contained in this report. Nonetheless, any person seeking to apply or consult the report is expected to use independent medical judgment in the context of individual clinical circumstances or seek out the supervision of a qualified clinician. Cancer Care Ontario makes no representation or guarantees of any kind (...) whatsoever regarding the report content or use or application and disclaims any responsibility for its application or use in any way Management of Cancer Medication-Related Infusion Reactions 2 ACKNOWLEDGEMENTS Working Group Members Dr. Leta Forbes, Medical Oncologist, Provincial Head, Systemic Treatment Program, Cancer Care Ontario, Co-chair Andrea Crespo, Sr. Pharmacist, Systemic Treatment Program, Cancer Care Ontario, Co-chair Daniela Gallo-Hershberg, Pharmacist, Group Manager, Systemic Treatment

2019 Cancer Care Ontario

164. Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome. (PubMed)

searched six Korean medical databases, and three Chinese medical databases from inception to 30 April 2018. We also searched clinical trials registries for ongoing trials.We included randomised and quasi-randomised trials examining the effects of acupuncture and related interventions on the symptoms of CTS in adults. Eligible studies specified diagnostic criteria for CTS. We included outcomes measured at least three weeks after randomisation. The included studies compared acupuncture and related (...) Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome. Carpal tunnel syndrome (CTS) is a compressive neuropathic disorder at the level of the wrist. Acupuncture and other methods that stimulate acupuncture points, such as electroacupuncture, auricular acupuncture, laser acupuncture, moxibustion, and acupressure, are used in treating CTS. Acupuncture has been recommended as a potentially useful treatment for CTS, but its effectiveness remains

2018 Cochrane

165. Perioperative beta-blockers for preventing surgery-related mortality and morbidity. (PubMed)

Perioperative beta-blockers for preventing surgery-related mortality and morbidity. Randomized controlled trials have yielded conflicting results regarding the ability of beta-blockers to influence perioperative cardiovascular morbidity and mortality. Thus routine prescription of these drugs in unselected patients remains a controversial issue.The objective of this review was to systematically analyse the effects of perioperatively administered beta-blockers for prevention of surgery-related (...) mortality and morbidity in patients undergoing any type of surgery while under general anaesthesia.We identified trials by searching the following databases from the date of their inception until June 2013: MEDLINE, Embase , the Cochrane Central Register of Controlled Trials (CENTRAL), Biosis Previews, CAB Abstracts, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Derwent Drug File, Science Citation Index Expanded, Life Sciences Collection, Global Health and PASCAL. In addition, we

2018 Cochrane

166. Ergonomic interventions for preventing work-related musculoskeletal disorders of the upper limb and neck among office workers. (PubMed)

(CENTRAL), MEDLINE, CINAHL, Web of Science (Science Citation Index), SPORTDiscus, Embase, the US Centers for Disease Control and Prevention, the National Institute for Occupational Safety and Health database, and the World Health Organization's International Clinical Trials Registry Platform, to 10 October 2018.We included randomised controlled trials (RCTs) of ergonomic interventions for preventing work-related upper limb or neck MSDs (or both) among office workers. We only included studies where (...) Ergonomic interventions for preventing work-related musculoskeletal disorders of the upper limb and neck among office workers. Work-related upper limb and neck musculoskeletal disorders (MSDs) are one of the most common occupational disorders worldwide. Studies have shown that the percentage of office workers that suffer from MSDs ranges from 20 to 60 per cent. The direct and indirect costs of work-related upper limb MSDs have been reported to be high in Europe, Australia, and the United States

2018 Cochrane

167. Implantable miniature telescope (IMT) for vision loss due to end-stage age-related macular degeneration. (PubMed)

Implantable miniature telescope (IMT) for vision loss due to end-stage age-related macular degeneration. Age-related macular degeneration (AMD) causes progressive and irreversible damage to the retina, resulting in loss of central vision. AMD is the third leading cause of irreversible visual impairment worldwide and the leading cause of blindness in industrialized countries. Since AMD is more common in older individuals, the number of affected individuals will increase significantly (...) Administration (FDA) Medical Devices database. The date of the search was 2 November 2017, with the exception of mRCT which is no longer in service.We planned to include randomized controlled trials (RCTs) and quasi-randomized trials that compared the IMT versus no IMT.Two review authors independently assessed all studies for inclusion, using standard methodological procedures expected by Cochrane.Our search yielded 1042 unique records. We removed irrelevant studies after screening titles and abstracts

2018 Cochrane

168. Effect of testing for cancer on cancer- or venous thromboembolism (VTE)-related mortality and morbidity in people with unprovoked VTE. (PubMed)

of a review first published in 2015.To determine whether testing for undiagnosed cancer in people with a first episode of unprovoked VTE (DVT of the lower limb or PE) is effective in reducing cancer or VTE-related mortality and morbidity and to determine which tests for cancer are best at identifying treatable cancers early.The Cochrane Vascular Information Specialist searched the Cochrane Vascular Specialised Register, CENTRAL, MEDLINE, Embase and CINAHL databases and World Health Organization (...) Effect of testing for cancer on cancer- or venous thromboembolism (VTE)-related mortality and morbidity in people with unprovoked VTE. Venous thromboembolism (VTE) is a collective term for two conditions: deep vein thrombosis (DVT) and pulmonary embolism (PE). A proportion of people with VTE have no underlying or immediately predisposing risk factors and the VTE is referred to as unprovoked. Unprovoked VTE can often be the first clinical manifestation of an underlying malignancy. This has

2018 Cochrane

169. Psychological interventions for needle-related procedural pain and distress in children and adolescents. (PubMed)

and adolescents.To assess the efficacy of psychological interventions for needle-related procedural pain and distress in children and adolescents.We searched six electronic databases for relevant trials: Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; PsycINFO; Embase; Web of Science (ISI Web of Knowledge); and Cumulative Index to Nursing and Allied Health Literature (CINAHL). We sent requests for additional studies to pediatric pain and child health electronic listservs. We also searched (...) Psychological interventions for needle-related procedural pain and distress in children and adolescents. This is the second update of a Cochrane Review (Issue 4, 2006). Pain and distress from needle-related procedures are common during childhood and can be reduced through use of psychological interventions (cognitive or behavioral strategies, or both). Our first review update (Issue 10, 2013) showed efficacy of distraction and hypnosis for needle-related pain and distress in children

2018 Cochrane

170. A study of the safety and harms of antidepressant drugs for older people: a cohort study using a large primary care database

A study of the safety and harms of antidepressant drugs for older people: a cohort study using a large primary care database A study of the safety and harms of antidepressant drugs for older people: a cohort study using a large primary care database Journals Library An error has occurred in processing the XML document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose (...) and related antidepressants. They may, however, be associated with increased risks for some adverse events. {{author}} {{($index An error has occurred in processing the XML document An error has occurred in processing the XML document {{metadata.Journal}} Volume: {{metadata.Volume}}, Issue: {{metadata.Issue}}, Published in {{metadata.PublicationDate | date:'MMMM yyyy'}} Citation: {{author}}{{ (($index {{(metadata.AuthorsArray.length {{(metadata.AuthorsArray.length > 6) ? 'et al.' : ''}} {{metadata.Title

2011 NIHR HTA programme

171. Urinary Proteomics in Predicting Heart Transplantation Outcomes (uPROPHET)-Rationale and database description. (PubMed)

and to identify key proteins mediating HTx-related complications; (iii) to validate UP classifiers by demonstrating analogy between UP profiles and tissue proteomic signatures (TP) in diseased explanted hearts, to be compared with normal donor hearts; (iv) and to identify new drug targets. This article describes the uPROPHET database construction, follow-up strategies and baseline characteristics of the HTx patients.HTx patients enrolled at the University Hospital Gasthuisberg (Leuven) collected mid-morning (...) Urinary Proteomics in Predicting Heart Transplantation Outcomes (uPROPHET)-Rationale and database description. Urinary Proteomics in Predicting Heart Transplantation Outcomes (uPROPHET; NCT03152422) aims: (i) to construct new multidimensional urinary proteomic (UP) classifiers that after heart transplantation (HTx) help in detecting graft vasculopathy, monitoring immune system activity and graft performance, and in adjusting immunosuppression; (ii) to sequence UP peptide fragments

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2017 PLoS ONE

172. CSmiRTar: Condition-Specific microRNA targets database. (PubMed)

CSmiRTar: Condition-Specific microRNA targets database. MicroRNAs (miRNAs) are functional RNA molecules which play important roles in the post-transcriptional regulation. miRNAs regulate their target genes by repressing translation or inducing degradation of the target genes' mRNAs. Many databases have been constructed to provide computationally predicted miRNA targets. However, they cannot provide the miRNA targets expressed in a specific tissue and related to a specific disease at the same (...) to search (i) a miRNA's targets expressed in a specific tissue or/and related to a specific disease, (ii) multiple miRNAs' common targets expressed in a specific tissue or/and related to a specific disease, (iii) a gene's miRNAs related to a specific disease, and (iv) multiple genes' common miRNAs related to a specific disease. We believe that CSmiRTar will be a useful database for biologists to study the molecular mechanisms of post-transcriptional regulation in human or mouse. CSmiRTar is available

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2017 PLoS ONE

173. National Database Could Help Students Pick College—and Income

National Database Could Help Students Pick College—and Income National Database Could Help Students Pick College—and Income | RAND Objective Analysis. Effective Solutions. Site-wide navigation Trending Topics Featured Research Activities Spotlight Commentary: Commentary: By Research Area Drawing upon decades of experience, RAND provides research services, systematic analysis, and innovative thinking to a global clientele that includes government agencies, foundations, and private-sector firms (...) appeared on on August 1, 2017. Routine data collected by the federal government could help students choose a college and a major—and help them calculate how much they stand to make once they graduate. Although the information exists, a searchable national database that could help students and their families make more informed decisions about college does not. The Higher Education Opportunity Act, passed in 2008, prevents the federal government from developing a database that would link information

2017 The RAND blog

174. Method to assess the temporal persistence of potential biometric features: Application to oculomotor, gait, face and brain structure databases. (PubMed)

Method to assess the temporal persistence of potential biometric features: Application to oculomotor, gait, face and brain structure databases. We introduce the intraclass correlation coefficient (ICC) to the biometric community as an index of the temporal persistence, or stability, of a single biometric feature. It requires, as input, a feature on an interval or ratio scale, and which is reasonably normally distributed, and it can only be calculated if each subject is tested on 2 or more (...) occasions. For a biometric system, with multiple features available for selection, the ICC can be used to measure the relative stability of each feature. We show, for 14 distinct data sets (1 synthetic, 8 eye-movement-related, 2 gait-related, and 2 face-recognition-related, and one brain-structure-related), that selecting the most stable features, based on the ICC, resulted in the best biometric performance generally. Analyses based on using only the most stable features produced superior Rank-1

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2017 PLoS ONE

175. Dueling BRCA Databases: What About the Patient?

database than anyone else, having been in the business so much longer. And it’s proprietary. CLASSIFYING GENE VARIANTS (NHGRI) Public databases of variants of health-related genes have been around for years too. The best known, , collects and curates from the biomedical literature, expert panels, reports at meetings, testing laboratories, and individual researchers, without access to Myriad’s database. ClinVar uses several standard technical criteria to as “pathogenic,” “benign,” or “of uncertain (...) . And then she might learn, as the databases grow, that her variant is really benign after all, because while she was being treated for a disease that she didn’t actually have, more patients emerged who have the gene variant but not the related cancers. The reclassification of a VUS as something more meaningful depends on access to as much information as possible. How many unnecessary surgeries are happening? Have happened? Myriad estimates hundreds to thousands. DISCOVERING DISCORDANCE The news release

2017 PLOS Blogs Network

176. Dueling BRCA Databases: What About the Patient?

database than anyone else, having been in the business so much longer. And it’s proprietary. CLASSIFYING GENE VARIANTS (NHGRI) Public databases of variants of health-related genes have been around for years too. The best known, , collects and curates from the biomedical literature, expert panels, reports at meetings, testing laboratories, and individual researchers, without access to Myriad’s database. ClinVar uses several standard technical criteria to as “pathogenic,” “benign,” or “of uncertain (...) . And then she might learn, as the databases grow, that her variant is really benign after all, because while she was being treated for a disease that she didn’t actually have, more patients emerged who have the gene variant but not the related cancers. The reclassification of a VUS as something more meaningful depends on access to as much information as possible. How many unnecessary surgeries are happening? Have happened? Myriad estimates hundreds to thousands. DISCOVERING DISCORDANCE The news release

2017 PLOS Blogs Network

177. Optimized grid representation of plant species richness in India-Utility of an existing national database in integrated ecological analysis. (PubMed)

Optimized grid representation of plant species richness in India-Utility of an existing national database in integrated ecological analysis. Data on the distribution of plant species at spatial (grid) scales are required as input for integrative analysis along with related climate, environment, topography and soil data. Although the world's scientific community is increasingly generating data on plant species at various spatial grids and statistically interpolating and extrapolating (...) the available information, data on plant diversity from the Asian continent are scant. Such data are unavailable for India, the mainland of which has part of three of the world's 36 biodiversity hotspots. Although sufficient field sampling is always impossible and impractical, it is essential to utilize fully any available database by adjudging the sampling sufficiency at a given scale. In this work, we used an exhaustive database of the plant species of the Indian mainland that was sufficient in terms

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2017 PLoS ONE

178. Estimating the Economic Burden of Rheumatoid Arthritis in Taiwan Using the National Health Insurance Database (PubMed)

Estimating the Economic Burden of Rheumatoid Arthritis in Taiwan Using the National Health Insurance Database Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and destruction of the joints.This research aims to estimate the economic burden of RA in Taiwan.The National Health Insurance Research Database (NHIRD), a claims-based dataset encompassing 99 % of Taiwan's population, was applied. We used a micro-costing approach for direct healthcare costs (...) and indirect social costs by estimating the quantities and prices of cost categories. Direct costs included surgeries, hospitalizations, medical devices and materials, laboratory tests, and drugs. The costs and quantities of the direct economic burden were calculated based on 2011 data of NHIRD. We identified RA patients and a control cohort matched 1:4 on demographic and clinical covariates to calculate the incremental cost related to RA. Indirect costs were evaluated by missed work (absenteeism

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2016 Drugs - real world outcomes

179. Intranasal Fluticasone Propionate Observational Cohort Safety Studies: Reviewing Evidence from Databases on Two Continents (PubMed)

Intranasal Fluticasone Propionate Observational Cohort Safety Studies: Reviewing Evidence from Databases on Two Continents Our objective was to highlight the importance of database selection in observational research and to determine the incidence of corticosteroid-related events in patients exposed to fluticasone propionate intranasal spray (FPNS) compared with other intranasal steroids (INS).After a feasibility study using an electronic medical record database in the UK (1990-2002 (...) ), a retrospective cohort study was conducted using a large administrative claims database in the USA from 1994 to 2002 comparing the incidence and rate ratios of steroid-related events among intermittent, sub-chronic, and chronic FPNS use and other INS use episodes.Most patients used INS intermittently; power was low to evaluate risk associated with chronic use. Significantly elevated adjusted rate ratios were observed in the US study comparing FPNS with other INS for hypercorticism, sinusitis, abscess

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2016 Drugs - real world outcomes

180. Erythrogene: a database for in-depth analysis of the extensive variation in 36 blood group systems in the 1000 Genomes Project (PubMed)

into the blood group genotypes obtained by NGS in a multiethnic cohort is lacking. The 1000 Genomes Project provides information on genome variation among 2504 individuals representing 26 populations worldwide. We extracted their NGS data for all 36 blood group systems to a custom-designed database. In total, 210 412 alleles from 43 blood group-related genes were imported and curated. Matching algorithms were developed to compare them to blood group variants identified to date. Of the 1241 non-synonymous (...) Erythrogene: a database for in-depth analysis of the extensive variation in 36 blood group systems in the 1000 Genomes Project Blood group genotyping has recently developed into a clinical tool to improve compatibility of blood transfusions and management of pregnancies. Next-generation sequencing (NGS) is rapidly moving toward routine practice for patient and donor typing and has the potential to remedy some of the limitations of currently used platforms. However, a large-scale investigation

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2016 Blood advances

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