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141. Intranasal Fluticasone Propionate Observational Cohort Safety Studies: Reviewing Evidence from Databases on Two Continents (PubMed)

Intranasal Fluticasone Propionate Observational Cohort Safety Studies: Reviewing Evidence from Databases on Two Continents Our objective was to highlight the importance of database selection in observational research and to determine the incidence of corticosteroid-related events in patients exposed to fluticasone propionate intranasal spray (FPNS) compared with other intranasal steroids (INS).After a feasibility study using an electronic medical record database in the UK (1990-2002 (...) ), a retrospective cohort study was conducted using a large administrative claims database in the USA from 1994 to 2002 comparing the incidence and rate ratios of steroid-related events among intermittent, sub-chronic, and chronic FPNS use and other INS use episodes.Most patients used INS intermittently; power was low to evaluate risk associated with chronic use. Significantly elevated adjusted rate ratios were observed in the US study comparing FPNS with other INS for hypercorticism, sinusitis, abscess

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2016 Drugs - real world outcomes

142. Erythrogene: a database for in-depth analysis of the extensive variation in 36 blood group systems in the 1000 Genomes Project (PubMed)

into the blood group genotypes obtained by NGS in a multiethnic cohort is lacking. The 1000 Genomes Project provides information on genome variation among 2504 individuals representing 26 populations worldwide. We extracted their NGS data for all 36 blood group systems to a custom-designed database. In total, 210 412 alleles from 43 blood group-related genes were imported and curated. Matching algorithms were developed to compare them to blood group variants identified to date. Of the 1241 non-synonymous (...) Erythrogene: a database for in-depth analysis of the extensive variation in 36 blood group systems in the 1000 Genomes Project Blood group genotyping has recently developed into a clinical tool to improve compatibility of blood transfusions and management of pregnancies. Next-generation sequencing (NGS) is rapidly moving toward routine practice for patient and donor typing and has the potential to remedy some of the limitations of currently used platforms. However, a large-scale investigation

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2016 Blood advances

143. Supporting Parents in Making Informed Decisions in Relation to their Children?s Health Needs

. Cochrane Database Systematic Reviews 2017; 2: Cd011787. 11. Kew KM, Malik P, Aniruddhan K, Normansell R. Shared decision-making for people with asthma. Cochrane Database of Systematic Reviews 2017; 10: Cd012330. 12. Feenstra B, Boland L, Lawson ML, et al. Interventions to support children's engagement in health-related decisions: a systematic review. BMC Pediatrics 2014; 14: 109. 13. Coyne I, O'Mathuna DP, Gibson F, Shields L, LeClerq E, Sheaf G. Interventions for promoting participation in shared (...) Supporting Parents in Making Informed Decisions in Relation to their Children?s Health Needs Rapid Synthesis Supporting Parents in Making Informed Decisions in Relation to their Children’s Health Needs 4 October 2018 McMaster Health Forum 1 Evidence >> Insight >> Action Rapid Synthesis: Supporting Parents in Making Informed-Decisions in Relation to their Children’s Health Needs 10-day response 4 October 2018 Supporting Parents in Making Informed Decisions in Relation to their Children’s Health

2018 McMaster Health Forum

144. Postpartum women living with HIV: Challenges related to retention in care, treatment adherence, and mental health

Postpartum women living with HIV: Challenges related to retention in care, treatment adherence, and mental health Postpartum women living with HIV: Challenges related to retention in care, treatment adherence, and mental health | The Ontario HIV Treatment Network The Ontario HIV Treatment Network Postpartum women living with HIV: Challenges related to retention in care, treatment adherence, and mental health Postpartum women living with HIV: Challenges related to retention in care, treatment (...) adherence, and mental health , , , , Questions What are the challenges related to retention in HIV care during the postpartum period? What are the challenges related to HIV treatment adherence during the postpartum period? What are the challenges related to postpartum depression among women living with HIV? What effective interventions or promising practices can be used to support women with the above issues (particularly interventions by social workers, community workers and peers)? Key take-home

2018 Ontario HIV Treatment Network

145. Effect of, and experiences with interventions for young people exposed to forced marriage or honour-related violence: A systematic literature search with sorting

to marry" OR "child marriage" OR "child marriages" OR "childhood marriage" OR "childhood marriages" OR "child bride" OR "child brides" OR "honor related" OR "honour related" OR "honor killings" OR "hon- our killings" OR "honor killing" OR "honour killing")) [Limit to year >2000] Database: NorArt Date: 05.09.2017 Hits: 75 Søk 1: [Ordsøk:] (((ære* OR skam OR "sosial kontroll") AND minorit*) OR tvangsekteskap) 52 18 [Limit to year >2000] Søk 2: [Ordsøk:] tvångsäektenskap OR "hedersrelaterat våld (...) " OR "childhood marriages" OR "child bride" OR "child brides" OR "honor related" OR "honour related" OR "honor killings" OR "honour killings" OR "honor killing" OR "honour killing" 2 7 tvangsekteskap OR tvångsäektenskap OR "tvangsægteskab" OR "æresrelateret vold" OR "hedersrelaterat våld" OR "æresdrap" OR "æresdrab" OR "hedersmord" OR hedersdråp OR skammord OR "hedersrelaterat förtryck" OR æresrelatert OR æresdrap 3 8 #6 OR #7 3 Database: Campbell Library Date: 05.09.2017 Hits: 0 [Search:] "coerced marriage

2018 Norwegian Institute of Public Health

146. Interventions for managing medication-related osteonecrosis of the jaw. (PubMed)

Interventions for managing medication-related osteonecrosis of the jaw. Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse reaction experienced by some individuals to certain medicines commonly used in the treatment of cancer and osteoporosis (e.g. bisphosphonates, denosumab and antiangiogenic agents) and involves the progressive destruction of bone in the mandible or maxilla. Depending on the drug, its dosage, and the duration of exposure, the occurrence of this adverse (...) exposed to antiresorptive or antiangiogenic drugs.To assess the effects of non-surgical or surgical interventions (either singly or in combination) versus no treatment, placebo, or an active control for the treatment of people with manifest MRONJ.Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (to 23 November 2016), the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library, 2016, Issue 10), MEDLINE Ovid

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2017 Cochrane

147. Different-sized incisions for phacoemulsification in age-related cataract. (PubMed)

in age-related cataract. The primary outcome of this review was surgically induced astigmatism at three months after surgery.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 10), MEDLINE Ovid (1946 to 28 October 2016), Embase Ovid (1947 to 28 October 2016), PubMed (1948 to 28 October 2016), LILACS (Latin American and Caribbean Health Sciences Literature Database) (1982 to 28 October 2016 (...) Different-sized incisions for phacoemulsification in age-related cataract. Age-related cataract is the principal cause of blindness and visual impairment in the world. Phacoemulsification is the main surgical procedure used to treat cataract. The comparative effectiveness and safety of different-sized incisions for phacoemulsification has not been determined.The aim of this systematic review was to assess the effectiveness and safety of smaller versus larger incisions for phacoemulsification

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2017 Cochrane

148. Ursodeoxycholic acid for cystic fibrosis-related liver disease. (PubMed)

Ursodeoxycholic acid for cystic fibrosis-related liver disease. Abnormal biliary secretion leads to the thickening of bile and the formation of plugs within the bile ducts; the consequent obstruction and abnormal bile flow ultimately results in the development of cystic fibrosis-related liver disease. This condition peaks in adolescence with up to 20% of adolescents with cystic fibrosis developing chronic liver disease. Early changes in the liver may ultimately result in end-stage liver disease (...) with people needing transplantation. One therapeutic option currently used is ursodeoxycholic acid. This is an update of a previous review.To analyse evidence that ursodeoxycholic acid improves indices of liver function, reduces the risk of developing chronic liver disease and improves outcomes in general in cystic fibrosis.We searched the Cochrane CF and Genetic Disorders Group Trials Register comprising references identified from comprehensive electronic database searches, handsearches of relevant

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2017 Cochrane

149. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. (PubMed)

Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. It has been proposed that antioxidants may prevent cellular damage in the retina by reacting with free radicals that are produced in the process of light absorption. Higher dietary levels of antioxidant vitamins and minerals may reduce the risk of progression of age-related macular degeneration (AMD).The objective of this review was to assess the effects of antioxidant vitamin or mineral (...) in the electronic searches for trials. We last searched the electronic databases on 29 March 2017.We included randomised controlled trials (RCTs) that compared antioxidant vitamin or mineral supplementation (alone or in combination) to placebo or no intervention, in people with AMD.Both review authors independently assessed risk of bias in the included studies and extracted data. One author entered data into RevMan 5; the other author checked the data entry. We graded the certainty of the evidence using

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2017 Cochrane

150. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. (PubMed)

Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. There is inconclusive evidence from observational studies to suggest that people who eat a diet rich in antioxidant vitamins (carotenoids, vitamins C, and E) or minerals (selenium and zinc) may be less likely to develop age-related macular degeneration (AMD).To determine whether or not taking antioxidant vitamin or mineral supplements, or both, prevent the development of AMD.We searched the Cochrane (...) Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2017, Issue 2), MEDLINE Ovid (1946 to 29 March 2017), Embase Ovid (1947 to 29 March 2017), AMED (Allied and Complementary Medicine Database) (1985 to 29 March 2017), OpenGrey (System for Information on Grey Literature in Europe) (www.opengrey.eu/); searched 29 March 2017, the ISRCTN registry (www.isrctn.com/editAdvancedSearch); searched 29 March 2017, ClinicalTrials.gov

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2017 Cochrane

151. N-acetylcarnosine (NAC) drops for age-related cataract. (PubMed)

) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 28 June 2016. We handsearched the American Society of Cataract and Refractive Surgery (ASCRS) and the European Society of Cataract and Refractive Surgeons (ESCRS) meetings from 2005 until September 2015.We planned to include randomized or quasi-randomised controlled trials where NAC was compared to control in people with age-related cataract.We (...) N-acetylcarnosine (NAC) drops for age-related cataract. Cataract is the leading cause of world blindness. The only available treatment for cataract is surgery. Surgery requires highly-trained individuals with expensive operating facilities. Where these are not available, patients go untreated. A form of treatment that did not involve surgery would be a useful alternative for people with symptomatic cataract who are unable or unwilling to undergo surgery. If an eye drop existed that could

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2017 Cochrane

152. Surgery for cataracts in people with age-related macular degeneration. (PubMed)

Surgery for cataracts in people with age-related macular degeneration. Cataract and age-related macular degeneration (AMD) are common causes of decreased vision that often occur simultaneously in people over age 50. Although cataract surgery is an effective treatment for cataract-induced visual loss, some clinicians suspect that such an intervention may increase the risk of worsening of underlying AMD and thus have deleterious effects on vision.The objective of this review was to evaluate (...) ), ClinicalTrials.gov (www.clinicaltrials.gov), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 2 December 2016.We included randomized controlled trials (RCTs) and quasi-randomized trials that enrolled participants whose eyes were affected by both cataract and AMD in which cataract surgery was compared

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2017 Cochrane

153. Rationale and Design of the Turkish Sleep Apnea Database - TURKAPNE: A National, Multicenter, Observational, Prospective Cohort Study (PubMed)

Rationale and Design of the Turkish Sleep Apnea Database - TURKAPNE: A National, Multicenter, Observational, Prospective Cohort Study The primary aim of The Turkish Sleep Apnea Database (TURKAPNE) study is to generate a cross-sectional nationwide database for defining the clinical and polysomnographic characteristics of the patients with obstructive sleep apnea (OSA) in Turkey.In this ongoing project, all consecutive adults with suspected OSA are recruited from the sleep centers (...) will contribute to a better understanding of the health-related burden of OSA phenotypes and its association with the comorbidities and adverse outcomes, including traffic accidents in Turkey. The results may also contribute to a more personalized approach and better management of varying OSA phenotypes with concomitant disorders.

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2018 Turkish Thoracic Journal

154. Limitations and opportunities in male fertility databases (PubMed)

Limitations and opportunities in male fertility databases Over the last several years, the male component of reproduction has begun to gain clinical momentum. The medical literature has traditionally focused on infertility from the female perspective, but recent publications have demonstrated that male infertility is an important marker of overall health for infertile men as well as their family members. In order to perform large-scale, quality research related to male infertility (...) , comprehensive databases are necessary. Currently, research in male infertility is limited by the fact that there is not a centralized, comprehensive database specifically designed to collect patient information related to male fertility. A database of this nature exists for female infertility research in the form of the Society for Assisted Reproductive Technology (SART) clinical summary report and the National ART Surveillance System (NASS) published by the Centers for Disease Control (CDC). This review

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2018 Translational andrology and urology

155. Prolonged dexmedetomidine infusion in critically ill adult patients: a retrospective analysis of a large clinical database Multiparameter Intelligent Monitoring in Intensive Care III (PubMed)

Prolonged dexmedetomidine infusion in critically ill adult patients: a retrospective analysis of a large clinical database Multiparameter Intelligent Monitoring in Intensive Care III There is no conclusive evidence for the effects of prolonged infusion of dexmedetomidine in critically ill patients. We aimed to investigate the safety of long-term dexmedetomidine infusion in a large critically ill patients cohort from the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC-III (...) ) database.We retrospectively extracted records from MIMIC-III database. Dexmedetomidine administration time was the basis for group. Variables were compared by chi-square tests, and Mann-Whitney U test as appropriate. We used logistic regression model for multivariate analysis. Contour maps were drawn to measure rebound of heart rate (HR) and blood pressure (BP).We finally got 1,946 records including 1,368 distinct individuals. Age, body mass index (BMI), length of stay in hospital, accumulated doses

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2018 Annals of Translational Medicine

156. Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer (PubMed)

Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer Exploring ERBB2-related pathways will help us finding sensitive molecules and potential combined therapeutic targets of ERBB2-targeted therapy for ERBB2+ gastric cancer (GC). In this study, we performed a cross-databases study focused on ERBB2+ GC. The data of ERBB2+ GC deposited in the cancer genome atlas (TCGA), gene expression omnibus (GEO), InBio MapTM, cancer cell line encyclopedia (CCLE

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2018 Frontiers in pharmacology

157. BioTIME: A database of biodiversity time series for the Anthropocene (PubMed)

of biodiversity in the Anthropocene.The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains metadata relating to sampling methodology and contextual information about each record.BioTIME is a global database of 547,161 unique sampling locations spanning the marine, freshwater and terrestrial realms. Grain size varies across datasets from 0.0000000158 km2 (158 cm2 (...) BioTIME: A database of biodiversity time series for the Anthropocene The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns

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2018 Global Ecology and Biogeography

158. HDncRNA: a comprehensive database of non-coding RNAs associated with heart diseases (PubMed)

HDncRNA: a comprehensive database of non-coding RNAs associated with heart diseases Heart diseases (HDs) represent a common group of diseases that involve the heart, a number of which are characterized by high morbidity and lethality. Recently, increasing evidence demonstrates diverse non-coding RNAs (ncRNAs) play critical roles in HDs. However, currently there lacks a systematic investigation of the association between HDs and ncRNAs. Here, we developed a Heart Disease-related Non-coding RNAs (...) in the human and mouse genomes; (iii) information about neighboring genes of lncRNAs and (iv) links to some mainstream databases including miRbase, Ensemble and Fantom Cat for the annotated lncRNAs and miRNAs. In summary, HDncRNA provides an excellent platform for exploring HDs related ncRNAs.Database URL: http://hdncrna.cardiacdev.com.

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2018 Database: The Journal of Biological Databases and Curation

159. Outcomes of patients in the national cancer database treated non-surgically for localized rectal cancer (PubMed)

rectal adenocarcinoma in the National Cancer Database (NCDB) undergoing definitive radiation without surgical intervention.The NCDB was queried for patients with non-metastatic rectal adenocarcinoma treated with definitive radiotherapy who did not undergo a surgical resection either because the patient refused surgery, surgery was medically contraindicated, or surgery was otherwise unplanned. Patient, tumor and treatment-related characteristics were compared between those treated with 45-50.3 Gray (...) Outcomes of patients in the national cancer database treated non-surgically for localized rectal cancer Some patients undergo a non-operative approach to localized rectal adenocarcinoma either because they decline surgery or because their medical comorbidities preclude surgical intervention. Published studies reporting excellent outcomes with a "wait-and-see" approach have been small and highly-selected. We aimed to analyze survival outcomes and prognostic factors for patients with localized

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2018 Journal of gastrointestinal oncology

160. Construction of an Electrocardiogram Database Including 12 Lead Waveforms (PubMed)

Construction of an Electrocardiogram Database Including 12 Lead Waveforms Electrocardiogram (ECG) data are important for the study of cardiovascular disease and adverse drug reactions. Although the development of analytical techniques such as machine learning has improved our ability to extract useful information from ECGs, there is a lack of easily available ECG data for research purposes. We previously published an article on a database of ECG parameters and related clinical data (ECG-ViEW (...) ), which we have now updated with additional 12-lead waveform information.All ECGs stored in portable document format (PDF) were collected from a tertiary teaching hospital in Korea over a 23-year study period. We developed software which can extract all ECG parameters and waveform information from the ECG reports in PDF format and stored it in a database (meta data) and a text file (raw waveform).Our database includes all parameters (ventricular rate, PR interval, QRS duration, QT/QTc interval, P-R-T

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2018 Healthcare informatics research

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