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Red Reflex

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1341. Safety and Tolerability Trial of Switching From Ropinirole to Rotigotine

, 28 days ] Change = 28 day value minus baseline value. Change in Percentage of Neutrophilic Granulocytes Segmented in White Blood Cell Count [ Time Frame: Baseline, 28 days ] Change = 28 day value minus baseline value. Change in Platelet Count [ Time Frame: Baseline, 28 days ] Change = 28 day value minus baseline value. Change in Red Blood Cell Count [ Time Frame: Baseline, 28 days ] Change = 28 day value minus baseline value. Change in White Blood Cell Count [ Time Frame: Baseline, 28 days (...) Examination for 'Metabolic/Endocrine' [ Time Frame: 28 days ] Occurrence of Abnormal, Clinically Relevant Events in Physical Examination for 'Other' [ Time Frame: 28 days ] Occurrence of Abnormal, Clinically Relevant Events in Neurological Examination for 'Mental Status' [ Time Frame: 28 days ] Occurrence of Abnormal, Clinically Relevant Events in Neurological Examination for 'Deep Tendon Reflexes' [ Time Frame: 28 days ] Occurrence of Abnormal, Clinically Relevant Events in Neurological Examination

2007 Clinical Trials

1342. Natural History of West Nile Virus Infection

, abnormal reflexes, generalized convulsions, or abnormal movements), or Cerebrospinal fluid (CSF) pleocytosis (white blood cell count greater than or equal to 4 per mm(3) corrected for red blood cell contamination in CSF) associated with illness clinically compatible with meningitis (e.g., headache or stiff neck) B. West Nile Fever Cohort: - Temperature greater than 38 C as documented by a health care provider. EXCLUSION CRITERIA: Unable to obtain valid informed consent. Alternate explanation

2003 Clinical Trials

1343. Screening Aid to Identify Corneas That May Have Pathologies or Other Conditions

mires, distortion of the retinoscopic, or ophthalmoscopic red reflex (or a combination of these) At least one of the following biomicroscopic signs: Vogt's striae, Fleischer's ring of >2 mm arc, or corneal scarring consistent with keratoconus. Contact lens wearers should discontinue use preferably 1 day or at least half an hour prior to imaging. Myopic Laser Vision Correction Patients who have undergone myopic: LASIK PRK LASEK Hyperopic Laser Vision Correction Patients who have undergone hyperopic (...) by distorted keratometry mires, distortion of the retinoscopic, or ophthalmoscopic red reflex (or a combination of these) At least one of the following biomicroscopic signs: Vogt's striae, Fleischer's ring of >2 mm arc, or corneal scarring consistent with keratoconus. Contact lens wearers should discontinue use preferably 1 day or at least half an hour prior to imaging. Myopic Laser Vision Correction Patients who have undergone myopic: LASIK PRK LASEK Hyperopic Laser Vision Correction Patients who have

2006 Clinical Trials

1344. The Safety, Tolerability And Metabolism Of GSK221149A, In Pregnant Women (30-36 Weeks), In Pre-Term Labor

evaluated for safety and were reviewed by the investigator or investigator designee. Number of participants with electrocardiogram values of potential clinical concern are presented. Number of Participants With Clinical Chemistry and Hematology Parameter Values of Potential Clinical Concern [ Time Frame: Up to 24 hours post-treatment ] Hematology parameters included complete blood count with red blood cell indices and white blood cell differential, platelet count, human immune deficiency virus (...) : extremely preterm (<28 weeks) very preterm (28 to <32 weeks). Number of participants with preterm births are presented. Neonatal Apgar Scores in Part A and B [ Time Frame: 1 minute and 5 minutes after birth ] APGAR scores range from 0 to 2 for each condition (color, reflex response, muscle tone, respiration and heart rate) with a maximum final total score of 10. For heart rate: 0=no heart rate, 1=<100 bpm (baby not very responsive), 2=>100 bpm (baby vigorous); for respiration: 0=no breathing, 1= weak

2006 Clinical Trials

1345. Screening for retinoblastoma: presenting signs as prognosticators of patient and ocular survival. (PubMed)

the red reflex test. Initial disease detection at the point of leukocoria or strabismus correlated with high patient survival rates and poor ocular survival rates for the presenting eye. Saving eyes and vision requires disease recognition before leukocoria, as demonstrated by the better ocular salvage rate among patients who had a positive family history and received clinical surveillance via early, routine dilated funduscopic examinations by an ophthalmologist.

2003 Pediatrics

1346. Natural history of Type A Niemann-Pick disease: possible endpoints for therapeutic trials. (PubMed)

, and sleep disturbance. Neurologic examination at the time of presentation was normal in most patients. Later neurologic examinations revealed progressive hypotonia with loss of the deep tendon reflexes. All patients had cherry red spots by 12 months. The median time from diagnosis to death was 21 months. The cause of death was respiratory failure in nine patients and complications from bleeding in the tenth.The clinical course in Type A Niemann-Pick disease is similar among affected patients

2006 Neurology

1347. Pathological C-fibres in patients with a chronic painful condition. (PubMed)

properties of mechano-insensitive fibres were pathological, being spontaneously active or sensitized to mechanical stimuli. Since these fibres also mediate the axon reflex flare, their hyperexcitability might account not only for ongoing pain and tenderness but also for redness and warming in this pain syndrome. The changes in conductive properties found in the C-fibres of these patients could be the first signs of a small-fibre neuropathy. This is the first systematic study of single C-fibres (...) Pathological C-fibres in patients with a chronic painful condition. Little is known about the contribution of C-afferent fibres to chronic painful conditions in humans. We sought to investigate the role of C-fibres in the pathophysiology of pain and hyperalgesia in erythromelalgia as a model disease for chronic pain. Erythromelalgia is a condition characterized by painful, red and hot extremities, and patients often report tenderness on walking. We made microneurographic recordings from single

2003 Brain

1348. Pupil findings in a consecutive series of 150 patients with generalised autonomic neuropathy. (PubMed)

Pupil findings in a consecutive series of 150 patients with generalised autonomic neuropathy. To detect and characterise the pattern and extent of pupil abnormalities in patients with generalised autonomic failure.A consecutive series of 150 patients referred for investigation of symptomatic generalised autonomic failure underwent pupil investigations. Infra-red video pupillography was used to measure resting pupil diameters in light and dark, the light reflex response, the miosis associated

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2006 Neurosurgery and Psychiatry

1349. Ocular fundus images by scanning laser ophthalmoscopy in a patient with enhanced S-cone syndrome. (PubMed)

Ocular fundus images by scanning laser ophthalmoscopy in a patient with enhanced S-cone syndrome. To present ocular fundus images in a patient with enhanced S-cone syndrome by scanning laser ophthalmoscopy. A 34-year-old Japanese woman whose parents were consanguineous showed mismatched electroretinographic responses to photopically balanced single-flash stimuli, with a larger signal to blue light than to red light. The central macula lacked a foveal reflex, and the surface was dull. Yellowish

2004 Retina

1350. Cataract blindness and visual outcome of cataract surgery in a tribal area in Pakistan. (PubMed)

eye with best available correction and with obvious central lens opacities/absence of red reflex in both eyes.A total of 1549 people were examined; the coverage rate was 96.8%. Of individuals who were examined, 958 (61.8%) were men. The overall prevalence of bilateral cataract blindness was 4.8% (95% CI: 3.8% to 5.9%). Women had a 2.1-fold greater prevalence of bilateral cataract blindness than men (7.1% (5.0% to 9.2%) v 3.4% (2.3% to 4.6%); p = <0.0001). However, cataract surgical coverage rates

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2006 British Journal of Ophthalmology

1351. Visual acuity, amblyopia, and ocular pathology in 12- to 13-year-old children in Northern Mexico. (PubMed)

Visual acuity, amblyopia, and ocular pathology in 12- to 13-year-old children in Northern Mexico. The aim of this study was to establish visual acuity (VA) and the prevalence of amblyopia and other ocular disorders in a population of 12- to 13-year-old children in Mexico who have not been vision screened.A total of 1,035 12- to 13-year-old children were examined in a field study. The examination included VA, stereopsis, cover testing, refractive retinoscopy, and examination of the red reflex

2003 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

1352. Referral patterns for common amblyogenic conditions. (PubMed)

refer within 2 months, while 38.6% would wait up to 12 months. In comparison, 48.7% of FPs would refer sooner, while 47.9% would refer later. These differences in referral patterns for pediatricians and FPs were statistically significant ( P = 0.037). There was less variation for referral of ptosis, nystagmus, and abnormal red reflex. These referral patterns were unaffected by years in practice.Pediatricians referred patients with strabismus significantly more promptly than FPs. The majority (...) practitioners (FPs) in Minnesota, asking them to use a multiple choice system to indicate how long after diagnosis they would wait before referring a child to an ophthalmologist for exotropia, esotropia, ptosis, nystagmus, and abnormal red reflex.The response rate was 46.9% ( n = 117) for pediatricians and 17.9% ( n = 240) for FPs. Of respondents, 64.6% of pediatricians and 50.2% of FPs would refer patients with exotropia within 2 months of diagnosis ( P < 0.001). For esotropia, 58.8% of pediatricians would

2005 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

1353. Pupil size and retinal straylight in the normal eye. (PubMed)

by using a white-light, CRT-based system for scattering angles of 3.5 degrees , 7 degrees , and 14 degrees . In the study of red-free light, a yellow-LED based system was used with the same five subjects for scattering angles of 3.5 degrees , 10 degrees , and 28 degrees . Data were analyzed to assess effects of (1) inhomogeneity of light-scattering over the pupil plane, (2) translucency of the eye wall, and (3) effects of the periphery of the lens. To estimate the order of magnitude of pupil (...) contraction in the typical glare situation, pupil reflexes resulting from the sudden appearance of headlight-equivalent bright lights were recorded in three subjects in a laboratory environment.For natural pupils (between 2 and 7 mm diameter), straylight weakly depends on pupil diameter (within 0.2 log units). For large scatter angles and small pupil diameters, eye wall translucency contributes significantly to straylight in a wavelength- and pigmentation-dependent manner. Pupil diameters decreased

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2007 Investigative Ophthalmology & Visual Science

1354. Capillary rarefaction and abnormal cardiovascular reactivity in hypertension. (PubMed)

Capillary rarefaction and abnormal cardiovascular reactivity in hypertension. To determine the effects of capillary rarefaction on cardiovascular reactivity and microcirculatory functioning in essential hypertension.Hypertension is associated with abnormal cardiovascular reactivity and increased vasoconstriction. Capillary rarefaction amplifies these abnormalities, which modify microcirculatory hemodynamics. Hence this study of the hemorheological pattern and the veno-arteriolar reflex (...) in hypertensive patients and normotensive control subjects.Sixty-one men with never-treated essential hypertension and capillary rarefaction (< 80 capillaries per field) and 20 age-matched and sex-matched controls underwent a strenuous cycle ergometer test to monitor, during exercise and recovery, the blood pressure profile and the hemorheological pattern: blood viscosity at low shear, hematocrit and leukocyte counts, soluble P-selectin levels, and red and white blood cell filterability rates. The veno

2003 Journal of Hypertension

1355. Treating the Ocular Component of Allergic Rhinoconjunctivitis and Related Eye Disorders (PubMed)

epidemiology, pathophysiology, and currently available treatment options, we performed a MEDLINE search for articles regarding ocular allergy, rhinoconjunctivitis, vernal keratoconjunctivitis (VKC), atopic keratoconjunctivitis (AKC), and giant papillary conjunctivitis (GPC).The more severe forms of ocular allergy are not only distressing, but can also threaten a patient's vision. Each type of ocular allergy is associated with ocular redness, itching, and tearing; however, AKC and VKC can threaten (...) suggests that nasal allergy treatments applied topically to the nose may also positively affect ocular allergy symptoms, which raises the interesting possibility that a parasympathetic nasal-ocular neural reflex pathway may be involved in the stimulation of allergic responses in the eye.Ocular allergy is underdiagnosed and has a significant impact on the life of the patient. It is vital to reach a better understanding of ocular allergic mechanisms and inflammation, which may lead to improved treatment.

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2007 Medscape General Medicine

1356. The management of posterior polar cataract: the role of patching and grading. (PubMed)

to the red reflex were introduced.Surgery followed from two weeks to three years after starting occlusion therapy. Before therapy, the best visual acuity was 0.3 and the worst 0.06 (median 0.16). A median of four years after starting therapy, the visual acuity ranged from 0.9 to 0.4 (median 0.6).All milder cases profited from the treatment despite its late start. An earlier discovery would improve the prognosis. In any case, however, ophthalmologists should be encouraged to try patching before resorting

2005 Strabismus

1357. Descriptive epidemiology of infantile cataracts in metropolitan Atlanta, GA, 1968-1998. (PubMed)

provides 31 years of data from a diverse US population and allows identification of risk factors for infantile cataracts. The finding that a number of infants with cataracts continue to have their conditions diagnosed after 6 weeks of age emphasizes the need for direct ophthalmoscopic examination of the red reflex in the newborn period to facilitate early detection and improve outcomes.

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2003 Archives of Pediatrics & Adolescent Medicine

1358. What is the symptomology of testicular torsion?

becomes red and oedematous.Pain is not relieved by elevating the twisted testis - negative Prehn's sign. The cremasteric reflex is absent. A neonatal torsion may be without symptoms and simply present as a hard, enlarged testes in a blue scrotum. They tend to present late, and it is more difficult to preserve the testes. Of boys presenting with acute scrotal swelling only 25% will have torsion of the testis. References Zwanger M, Rupp T. Testicular Torsion. eMedicine. If diagnosed early, a near 100 (...) Active cremasteric reflex Cold weather Involved testicle painful to palpation; frequently elevated in position when compared to the other side Horizontal lie of the testicle Enlargement and edema of the testicle; edema involving the entire scrotum Scrotal erythema Ipsilateral loss of the cremasteric reflex Usually, no relief of pain upon elevation of scrotum (elevation may improve the pain in epididymitis [Prehn sign]) Fever (uncommon) History includes a sudden onset of severe unilateral scrotal pain

2002 TRIP Answers

1359. Effect of baseline vascular tone on vasomotor responses in cat lip. (PubMed)

Effect of baseline vascular tone on vasomotor responses in cat lip. 1. Parasympathetic vasodilator and sympathetic vasoconstrictor responses were monitored using laser Doppler measurement of red cell flux in the lips of anaesthetized and artificially ventilated cats. 2. Three relationships were investigated: (i) that between the reflex parasympathetic vasodilator response induced by lingual nerve (LN) stimulation and baseline red cell flux (BRCF) levels adjusted by repetitive stimulation

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1995 The Journal of physiology

1360. Enhanced Behavioral Recovery from Sensorimotor Cortex Lesions After Pyramidotomy in Adult Rats (PubMed)

Enhanced Behavioral Recovery from Sensorimotor Cortex Lesions After Pyramidotomy in Adult Rats Unilateral transection of the bulbar pyramid, performed before the ablation of the ipsilateral sensorimotor cortex, has been shown to facilitate the recovery of operantly conditioned reflexes and compensatory processes in rats. Such enhanced behavioral recovery was absent when only the sensorimotor cortex was ablated. This phenomenon is explained by the switching of motor activity under the control (...) of the cortico-rubrospinal system. Switching of the descending influences is accomplished through the following loop: cortico-rubral projection-red nucleus-inferior olive-cerebellum-thalamus-cerebral cortex. This suggests that a preliminary lesion of the peripheral part of the system, represented by a descending spinal projection, facilitates the recovery processes to develop during the subsequent destruction of its central part.

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2000 Neural plasticity

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