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182. Exercise for preventing recurrent ankle sprain

General Practice Programs for educators Regional Training The Red Book provides the general practice team with guidance on opportunistic and proactive preventive care Guidelines by topic Key RACGP guidelines Handbook of Non-Drug Interventions (HANDI) Send a request for information, a loan, literature search, journal article, book chapter and one-on-one remote training sessions Library services eBooks Journals Databases and resources Subject portals Download the Standards for general practice (5th (...) the underlying causes of the sprained ankle. The purpose of the exercise is to re-establish and strengthen the muscles and protective reflexes of the ankle. Indication Patients aged 12 to 70 years experiencing recurrent ankle sprain after initial recovery. Precautions The clinical trials cited were designed to investigate efficacy not safety so safety was often not reported as part of the trial outcomes. Presumably, as with other exercise regimens, there is an inherent risk of exercise-related injury, falls

2013 Handbook of Non-Drug interventions (HANDI)

183. Breastfeeding problems

. Alcohol and smoking history. Associated insomnia, stress, anxiety, or depression. Infant history: Birth gestation, any birth trauma or known medical conditions or congenital abnormalities. Birth weight, weight gain, general health and behaviour (settled or crying). Behaviour at the breast (pulling, biting, coughing, breathlessness, sleepiness) which may be a consequence of nasal congestion, teething, or an overactive milk ejection reflex. Gastrointestinal symptoms which may suggest oversupply of milk (...) , redness, and fissuring. See the CKS topic on for more information. Candida infection typically causes bilateral burning nipple pain, itching, and hypersensitivity of the nipple, especially during and soon after feeds. There may be deep breast pain radiating into the breast and chest wall ( pain). The nipple may be red, shiny, swollen, or fissured. Typically the pain does not resolve despite improved positioning and attachment, or follows a period of pain-free breastfeeding. See the CKS topic

2017 NICE Clinical Knowledge Summaries

185. Nouriast (istradefylline)

and usage conditions in foreign countries etc. Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor deficits including akinesia, rigidity, bradykinesia, and postural reflex impairment, resulting from the degeneration and loss of dopaminergic neurons projecting from the midbrain substantia nigra pars compacta to the striatum and a subsequent reduction in striatal dopamine content. Due to dopamine D 2 receptor-mediated inhibitory control over the GABAergic (...) (weighing 19-26 g, n = 3) were assessed by Irwin test. Istradefylline at =1 mg/kg increased stereotypy, motor activity, autonomic function, alertness, and response to stimulus and caused red skin and enlargement of the eyelids. An increase in respiratory rate was observed at =10 mg/kg. The effects of istradefylline (10-300 mg/kg) in male CD-1 mice (6 weeks of age, n = 4) were assessed by Irwin test. At =30 mg/kg of istradefylline, increases in touch response and grooming were observed continuously after

2013 Pharmaceuticals and Medical Devices Agency, Japan

186. Lyxumia (lixisenatide)

after lixisenatide administration. 10 Aqueous solution containing 1.5% methylcellulose and 0.05% methyl red 9 3.(i).A.(1).2).(a).iii) Effects on blood glucose levels in ZDF rats ( A single subcutaneous dose of lixisenatide (1, 5, 10 µg/kg) or vehicle 11 was given to male obese Zucker Diabetic Fatty (ZDF) rats (11 weeks of age, 8 rats/group) under fasted conditions and a single subcutaneous dose of vehicle was given to male lean ZDF rats (11 weeks of age, 8 rats). Thirty minutes later (...) apathy, abnormal dispersion within the home cage, and slight to moderate impairment of the righting reflex were observed at =10 µg/kg, but these signs resolved by Study Day 2. Slight and transient clonic convulsion was observed in 1 rat at 50 µg/kg. Estimated blood concentrations following single intravenous doses of 1 and 10 µg/kg of lixisenatide are approximately 20 and 200 ng/mL, respectively, which are 19- and 190-fold of the C max following once daily subcutaneous administration of 20 µg

2013 Pharmaceuticals and Medical Devices Agency, Japan

188. Why is antivaccine activist Robert F. Kennedy, Jr. meeting with government health and science officials months after meeting with President Trump?

give Helen Branswell, who wrote this otherwise excellent report, a word of advice: RFK Jr. is not a "vaccine skeptic," leading or otherwise. He is antivaccine to the core and has been spewing antivaccine pseudoscience since at least 2005. Skepticism does not mean reflex rejection of the scientific consensus in favor of pseudoscience, but that is exactly what RFK Jr. does: Reject the scientific consensus and embrace pseudoscience. If there's something that reporters do that really grate on me, it's (...) Report by Kent Heckenlively: Basant Puri has promoted a supplement he sells (VegEPA) based on dodgy research. Ben Goldacre told the tale: Lots of dodgy stuff there for all three, plus the red flags of citing dubious studies. to post comments By on 27 Aug 2017 In reply to by Brian Deer (not verified) to post comments By Michael J. Dochniak (not verified) on 27 Aug 2017 to post comments By Michael J. Dochniak (not verified) on 27 Aug 2017 to post comments By Julian Frost (not verified) on 27 Aug 2017

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2017 Respectful Insolence

189. “Vaccine Awareness Week,” misinformed consent, and, of course, Nazis and eugenics

hesitant who are in actuality antivaccine, people like Barbara Loe Fisher. Coney is also quoted as saying: >We reflexively blame outbreaks of vaccine-preventable diseases on supposedly irrational anti-vaccinationists. In doing so, we often neglect to consider the shortcomings of vaccination and the many reasons children lack vaccinations: age, religious beliefs, medical contraindications, poverty, challenges accessing healthcare, and more. It’s not just about philosophical objections. Which is a well (...) . beckyfisseux Eh? beckyfisseux Oh – I see. Not me. (I hope!) JP Now, I’ve heard of race baiting and Red-baiting, but what the hell is “class baiting”? Oh. It is Ah. Haha. Hahaha. Hahahahahahahhaha! Welcome back! JDK Welcome back, Orac! and a sideways thanks to NVIC for giving you a topic (target?) for your return. Narad using the materialist philosophy So, is Babs invoking supernaturalism, idealism, or straight-up philosophical nihilism? Shush! You don’t want to make her have to think about her words

2017 Respectful Insolence

190. Funtabulously Frivolous Friday Five 203

is least likely to wake if a smoke alarm sounds? The boy , is this proof of selective hearing at an early age? Research in the UK is testing a new smoke alarm as industry standard alarms are failing to wake boys aged 2 to 13. It consists of a lower tone and a female voice. [ ] Question 3 Just 2kg of this substance would kill everyone on the planet. What is it? Botulinum, whose up for some botox? See the link for the accompanying video from the BBC. Question 4 Adding red chillies to the diet (...) of the elderly may help prevent what disorder? Aspiration pneumonia Daily capsaicin supplementation resulted in a significant improvement in the upper protective respiratory reflexes in 50% of elderly people from a study in Japan. [ ] However, caution should be advised before every nursing home starts growing the Carolina Reaper. 8 adults in China have suffered from cayenne aspiration requiring bronchoscopy. [ ] Question 5 Which disease killed 800 out of 2400 Chinese labourers in Malaya in the early days

2017 Life in the Fast Lane Blog

191. No, vaccines do not cause sudden infant death syndrome, a Vaccine Court decision notwithstanding

developed.” His chest and lungs were normal with no adventitious sounds. J.B.’s heart rate was regular with normal heart sounds and no pericardial friction rubs...His reflexes were all 2/2 and his red reflex was normal. His weight was 16 pounds, 8 ounces... For infants of his age, his weight was stable at the 50th percentile, his height was up at the 50th percentile, and his head circumference was at the 75th percentile. Nasal mucosa was normal, turbinates were normal, and nares were patent. Oropharynx

2017 Respectful Insolence

192. Robert F. Kennedy, Jr. and Robert De Niro issue a $100,000 vaccine “challenge.” It’s every bit as much as scam as Jock Doubleday’s “vaccine challenge” was a decade ago.

whistleblower." I've dealt with that conspiracy theory now more times than I can remember, and the actual documents dumped by William Thompson (the CDC scientist and so-called "CDC whistleblower") showed to cover up evidence that vaccines cause autism. that was at the heart of . We are both pro-vaccine. We need to say this at the outset to contravene the reflexive public relations ploy of labeling every vaccine safety advocate "anti-vaccine." As the British Medical Journal pointed out last week

2017 Respectful Insolence

193. Resuscitated from ventricular fibrillation: what is the ECG Diagnosis?

(I, II, III), (aVR, aVL, aVF), (V1, V2, V3), you can draw a line up and see the end of the QRS in all leads. In this way, one can see the subtle, downsloping ST elevation in aVL, with reciprocal ST depression in II, III, and aVF. Here it is: His response: Yes. This was an interesting case, especially when you red the providers' interpretations of the ECGs. After the 2nd ECG the diagnosis should be clear, but for some reason they call it "NSTEMI". No cath done initially, and on day 3 they decided (...) hour down time prior to being resuscitated. She has been without sedation for several hours and has no corneal or gag reflexes per the primary team. There is enough evidence to call into question her neurological viability at this time, thus a left heart catheterization would be of questionable utility.” Autopsy, day 7: Anoxic brain injury with total cerebral necrosis 99% stenosis of the proximal LAD, with acute transmural infarct of the anterior and anterolateral walls of the LV 75% stenosis LCx

2016 Dr Smith's ECG Blog

197. Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 1: Classification of Sports: Dynamic, Static, and Impact

by increasing blue intensity and increasing static load by increasing red intensity. Note the graded transition between categories, which should be individualized on the basis of player position and style of play. *Danger of bodily collision (see Table for more detail on collision risk). †Increased risk if syncope occurs. Modified from Mitchell et al with permission. Copyright © 2005, Journal of the American College of Cardiology . Static contractions stimulate mechanical and metabolic afferents in skeletal (...) muscle, which leads to large, sustained changes in blood pressure via the exercise pressor reflex. The larger the muscle mass involved, the greater the intensity of contraction, and the greater the rise in blood pressure ; incorporation of a Valsalva maneuver during contractions will acutely and transiently increase transmural arterial pressure markedly in blood vessels outside of the chest, although left ventricular (LV) afterload does not appear to increase because of a balanced rise

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2015 American Heart Association

199. Allergic Rhinitis

) Clinicians should make the clinical diagnosis of AR when patients present with a history and physical examination consistent with an allergic cause and 1 or more of the following symptoms: nasal congestion, runny nose, itchy nose, or sneezing. Findings of AR consistent with an allergic cause include, but are not limited to, clear rhinorrhea, nasal congestion, pale discoloration of the nasal mucosa, and red and watery eyes. (2) Clinicians should perform and interpret, or refer to a clinician who can (...) the clinical diagnosis of AR when patients present with a history and physical examination consistent with an allergic cause and 1 or more of the following symptoms: nasal congestion, runny nose, itchy nose, or sneezing. Findings of AR consistent with an allergic cause include, but are not limited to, clear rhinorrhea, nasal congestion, pale discoloration of the nasal mucosa, and red and watery eyes. Recommendation based on observational studies, with a preponderance of benefit over harm. Action Statement

2015 American Academy of Otolaryngology - Head and Neck Surgery

200. Adult Sinusitis

attention should be paid to the presence or absence of the following: altered (hyponasal) speech indicating nasal obstruction, swelling, redness of the skin due to congestion of the capillaries (erythema) or abnormally large fluid volume (edema) localized over the involved cheek bone or periorbital area; palpable cheek tenderness or percussion tenderness of the upper teeth; purulent drainage in the nose or posterior pharynx; and signs of extra-sinus involvement (orbital or facial cellulitis, orbital

2015 American Academy of Otolaryngology - Head and Neck Surgery

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