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Rachitic Rosary

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1. ‘Rachitic rosary sign’ and ‘tie sign’ of the sternum in tumour-induced osteomalacia (Full text)

‘Rachitic rosary sign’ and ‘tie sign’ of the sternum in tumour-induced osteomalacia 26907825 2016 12 13 2018 11 13 1757-790X 2016 2016 Feb 23 BMJ case reports BMJ Case Rep 'Rachitic rosary sign' and 'tie sign' of the sternum in tumour-induced osteomalacia. 10.1136/bcr-2016-214766 bcr2016214766 Chakraborty Partha Pratim PP Department of Medicine, Midnapore Medical College & Hospital, Midnapore, West Bengal, India. Bhattacharjee Rana R Department of Endocrinology & Metabolism, Institute

2016 BMJ case reports PubMed

2. Rachitic Rosary

Rachitic Rosary Rachitic Rosary Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Rachitic Rosary Rachitic Rosary Aka: Rachitic Rosary (...) II. Definition Enlargement of costochondral junctions III. Differential Diagnosis Rounded knobs form at costochondral junction Flat depression at costochondral junction Chondrodystrophy Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Rachitic Rosary." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Beading of ribs (C0426824) Concepts

2018 FP Notebook

3. Rachitic Rosary

Rachitic Rosary Rachitic Rosary Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Rachitic Rosary Rachitic Rosary Aka: Rachitic Rosary (...) II. Definition Enlargement of costochondral junctions III. Differential Diagnosis Rounded knobs form at costochondral junction Flat depression at costochondral junction Chondrodystrophy Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Rachitic Rosary." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Beading of ribs (C0426824) Concepts

2015 FP Notebook

4. Vitamin D deficiency

://www.ncbi.nlm.nih.gov/pubmed/23790560?tool=bestpractice.com History and exam presence of risk factors bowing of the legs widening of the ends of the long bones delayed tooth eruption and early dental caries chest deformity throbbing, aching bone discomfort and/or irritability head sweating localised or generalised bone tenderness proximal muscle weakness rachitic rosary frontal bossing waddling gait failure to thrive delayed achievement of motor milestones fatigue and malaise symptoms of hypocalcaemia inadequate

2018 BMJ Best Practice

5. DMP1 Ablation in the Rabbit Results in Mineralization Defects and Abnormalities in Haversian Canal/Osteon Microarchitecture. (PubMed)

(that occurs only in large mammalian bones), high levels of fibroblast growth factor 23 (FGF23), and PTH, in comparison with a moderate elevation of FGF23 and unchanged PTH in human ARHR patients. To better understand this rare disease, we deleted the DMP1 gene in rabbit using CRISPR/Cas9. This rabbit model recapitulated many features of human ARHR, such as the rachitic rosary (expansion of the anterior rib ends at the costochondral junctions), moderately increased FGF23, and normal PTH levels, as well

2019 Journal of Bone and Mineral Research

6. Vitamin D deficiency in children

-hydroxyvitamin D (25[OH]D) levels, if a child or young person presents with: Symptoms and signs of rickets, including: Progressive bowing of legs (be aware that bowing of legs can be a normal finding in toddlers). Progressive knock knees. Painful wrist swelling. Rachitic rosary (swelling of the costochondral junctions). Craniotabes (skull softening with frontal bossing and delayed fontanelle closure). Delayed tooth eruption and enamel hypoplasia. Other symptoms or conditions associated with vitamin D

2016 NICE Clinical Knowledge Summaries

7. Vitamin D deficiency causes rickets in an urban informal settlement in Kenya and is associated with malnutrition. (Full text)

with rickets had wrist widening (100%) and rachitic rosary (90%), as opposed to lower limb features (19%). Developmental delay (52%), acute malnutrition (71%), and stunting (62%) were common. Compared to controls, there were no differences in calcium intake, but most (71%) had serum 25-hydroxyvitamin D levels below 30 nmol/L. These results suggest that rickets in young children in urban Kenya is usually driven by vitamin D deficiency, and vitamin D supplementation is likely to be required for full recovery

2017 Maternal & child nutrition PubMed

8. A novel mutation in the hepatocyte nuclear factor-1β gene in maturity onset diabetes of the young 5 with multiple renal cysts and pancreas hypogenesis: A case report (Full text)

quadratus, rachitic rosary and a visible toe-out gait. Laboratory examinations revealed that the patient's fasting plasma glucose and glycosylated hemoglobin levels were markedly increased, fasting plasma C-peptide level was slightly increased and no peak 2 h postprandial was observed. Diabetic autoimmune antibodies [islet cell cytoplasmic autoantibodies (ICA), glutamic acid decarboxylase autoantibodies (GADA), isulinoma-2-associated autoantibodies (IA2A) and insulin autoantibodies (IAA)] were negative

2017 Experimental and therapeutic medicine PubMed

9. Congenital rickets due to vitamin D deficiency in the mothers. (PubMed)

of these cases. In 16 cases the diagnosis of the rickets led to the identification of symptomatic osteomalacia in the mothers. Of the 12 mothers who had assays for serum 25-hydroxyvitamin D (25OHD) 11 had values less than 10 ng/mL. Presentations in the infants included craniotabes, wide skull sutures, rachitic rosaries, enlargement of the wrists, tetany and convulsions. In two cases rickets had been suspected from antenatal X-rays. In five cases fractures were found at the time of initial presentation

2014 Clinical nutrition (Edinburgh, Scotland)

10. Disorders of Bone Mineralization (Diagnosis)

features of and hyperphosphatemia include seizures, apnea, and tetany. In children, clinical features of rickets include the following (see the images below): Delayed motor milestones Hypotonia Enlargement of wrists Progressive bowing of long bones Rachitic rosary Harrison sulcus Violin case deformity of the chest Late closure of anterior fontanelle Parietal and frontal bossing Craniotabes Craniosynostosis Delay in teeth eruption Enamel hypoplasia Decreased bone mineral density Myopathy with normal

2014 eMedicine Pediatrics

11. Disorders of Bone Mineralization (Treatment)

features of and hyperphosphatemia include seizures, apnea, and tetany. In children, clinical features of rickets include the following (see the images below): Delayed motor milestones Hypotonia Enlargement of wrists Progressive bowing of long bones Rachitic rosary Harrison sulcus Violin case deformity of the chest Late closure of anterior fontanelle Parietal and frontal bossing Craniotabes Craniosynostosis Delay in teeth eruption Enamel hypoplasia Decreased bone mineral density Myopathy with normal

2014 eMedicine Pediatrics

12. Disorders of Bone Mineralization (Overview)

features of and hyperphosphatemia include seizures, apnea, and tetany. In children, clinical features of rickets include the following (see the images below): Delayed motor milestones Hypotonia Enlargement of wrists Progressive bowing of long bones Rachitic rosary Harrison sulcus Violin case deformity of the chest Late closure of anterior fontanelle Parietal and frontal bossing Craniotabes Craniosynostosis Delay in teeth eruption Enamel hypoplasia Decreased bone mineral density Myopathy with normal

2014 eMedicine Pediatrics

13. Scurvy

changes may be below the resolution of computed tomography (CT) or magnetic resonance imaging (MRI). A change in skull shape is not diagnostic, as this finding may also be seen with hemolytic anemia, other causes of bone marrow hyperplasia, and rickets. [ , , ] Previous Next: Nuclear Imaging Technetium bone scans are not routinely performed in patients with scurvy; however, increased uptake at the distal metaphyses and the epiphyses and formation of a rachitic rosary are hypothetically possible

2014 eMedicine Radiology

14. Osteomalacia and Renal Osteodystrophy

and ulna, and proximal humerus. Anteroposterior radiograph of the wrist in a child with renal failure reveals cupping and fraying of the metaphysis and irregularity of the epiphyseal margins compatible with renal rickets (arrowheads). The coarsened trabeculae are a feature of osteomalacia (arrows). Anteroposterior radiograph of the right hemithorax in a child with chronic renal failure and rachitic rosary reveals abnormal widening of the anterior ribs at the costochondral junctions (arrows (...) in a child with chronic renal failure and rachitic rosary reveals abnormal widening of the anterior ribs at the costochondral junctions (arrows). Magnified anteroposterior radiograph of the proximal tibia in a patient with chronic renal failure reveals a Looser fracture (pseudofracture) at the proximal medial tibia (arrow). Anteroposterior radiograph of the distal forearm in a patient with chronic renal failure reveals an expansile lytic lesion (brown tumor) in the distal ulna (arrows). A. Lateral

2014 eMedicine Radiology

15. Disorders of Bone Mineralization (Follow-up)

features of and hyperphosphatemia include seizures, apnea, and tetany. In children, clinical features of rickets include the following (see the images below): Delayed motor milestones Hypotonia Enlargement of wrists Progressive bowing of long bones Rachitic rosary Harrison sulcus Violin case deformity of the chest Late closure of anterior fontanelle Parietal and frontal bossing Craniotabes Craniosynostosis Delay in teeth eruption Enamel hypoplasia Decreased bone mineral density Myopathy with normal

2014 eMedicine Pediatrics

16. Vitamin Deficiency, Dependency, and Toxicity - Vitamin D

of the skull and costochondral thickening. Costochondral thickening can look like beadlike prominences along the lateral chest wall (rachitic rosary). In children 1 to 4 yr, epiphyseal cartilage at the lower ends of the radius, ulna, tibia, and fibula enlarge; kyphoscoliosis develops, and walking is delayed. In older children and adolescents, walking is painful; in extreme cases, deformities such as bowlegs and knock-knees develop. The pelvic bones may flatten, narrowing the birth canal in adolescent girls

2013 Merck Manual (19th Edition)

17. Osteomalacia and Rickets (Vitamin D Deficiency)

-bowing and knock knees. There may be bony deformities of the chest, pelvis and skull, delayed dentition, poor growth, and bone pain. Softening of the skull (craniotabes) and frontal bossing in the first few months of life; delayed closure of fontanelles. Tender swollen joints. Enlargement of the ends of the ribs ('rachitic rosary') due to expansion of the costochondral junction in a 3- to 6-month-old child. Deformed bones, bowing of the legs, knock knees. Delayed walking or a waddling gait. Impaired (...) have difficulty walking and may have a waddling gait or a change in gait, with proximal muscle weakness and marked adductor spasm. Other signs include costochondral swelling (rachitic rosary), spinal curvature and signs of hypocalcaemia (eg, tetany, carpopedal spasm). Tenderness over pseudofractures (which represent a lucent band of decreased cortical density, perpendicular to bone surface, often multiple, and with or without callus formation). The patient may experience multiple fractures which

2008 Mentor

18. Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statement

Drugs: rifampicin, isoniazid and anticonvulsants 25-OHD = 25-hydroxyvitamin D or calcidiol. 1,25-(OH) 2 D = 1,25-dihydroxyvitamin D or calcitriol. 2 Osseous signs of vitamin D deficiency (common to less common) Swelling of wrists and ankles Rachitic rosary (enlarged costochondral joints felt lateral to the nipple line) Genu varum, genu valgum or windswept deformities of the knee Frontal bossing Limb pain and fracture Craniotabes (softening of skull bones, usually evident on palpation of cranial (...) not resolve after adequate treatment, the child should be investigated for a malabsorption disorder (eg, coeliac disease) or a genetic rachitic disorder (eg, X-linked hypophosphataemic rickets). The most serious consequence of vitamin D deficiency is hypocalcaemic seizure. While most common in infants aged less than 6 months, seizures can occur at any age. Bolus intravenous calcium is indicated to treat seizures and carpopedal spasm. A calcium infusion may be required if control is not achieved with 1

2006 MJA Clinical Guidelines

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