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REM Sleep Behavior Disorder

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161. Heartbeat Evoked Potentials During Sleep and Daytime Behavior in Children with Sleep Disordered Breathing. (PubMed)

Heartbeat Evoked Potentials During Sleep and Daytime Behavior in Children with Sleep Disordered Breathing. Event-related brain potentials allow probing of cortical information processing, but when evoked with externally induced stimuli may disrupt sleep homeostasis and do not provide insight into intrinsic cortical information processing. To investigate if cortical processing of intrinsic information in children with sleep-disordered breathing (SDB) is different from healthy children and, if so (...) , whether it resolves with treatment, we used heartbeat as a source of interoceptive event-related brain potentials.To investigate heartbeat evoked potentials (HEP) during sleep in healthy children and in children with SDB before and after treatment and to explore if there are any associations between HEP and daytime behavioral deficits in children with SDB.Heartbeat-aligned EEG was assessed for presence of HEP within stage 2, slow-wave sleep, and REM sleep in 40 children with primarily mild to moderate

2014 American Journal of Respiratory and Critical Care Medicine

162. Investigating rapid eye movement sleep without atonia in Parkinson's disease using the rapid eye movement sleep behavior disorder screening questionnaire. (PubMed)

Investigating rapid eye movement sleep without atonia in Parkinson's disease using the rapid eye movement sleep behavior disorder screening questionnaire. Rapid eye movement (REM) sleep behavior disorder (RBD) is frequently observed in patients with Parkinson's disease (PD). Accurate diagnosis is essential for managing this condition. Furthermore, the emergence of idiopathic RBD in later life can represent a premotor feature, heralding the development of PD. Reliable, accurate methods (...) for identifying RBD may offer a window for early intervention. This study sought to identify whether the RBD screening questionnaire (RBDSQ) and three questionnaires focused on dream enactment were able to correctly identify patients with REM without atonia (RWA), the neurophysiological hallmark of RBD. Forty-six patients with PD underwent neurological and sleep assessment in addition to completing the RBDSQ, the RBD single question (RBD1Q), and the Mayo Sleep Questionnaire (MSQ). The REM atonia index

2014 Movement Disorders

163. Neuropsychological Characterization of Evolving Cognitive Decline in Idiopathic REM Sleep Behavior Disorder Is Important, But Not Easy (PubMed)

Neuropsychological Characterization of Evolving Cognitive Decline in Idiopathic REM Sleep Behavior Disorder Is Important, But Not Easy 21532947 2011 08 31 2018 11 13 1550-9109 34 5 2011 May 01 Sleep Sleep Neuropsychological characterization of evolving cognitive decline in idiopathic REM sleep behavior disorder is important, but not easy. 561-2 Boeve Bradley F BF Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. bboeve@mayo.edu Ferman Tanis J TJ eng AG 15866 (...) physiopathology Humans Neuropsychological Tests REM Sleep Behavior Disorder complications physiopathology 2011 5 3 6 0 2011 5 3 6 0 2011 9 1 6 0 epublish 21532947 PMC3079933 J Int Neuropsychol Soc. 2002 Nov;8(7):907-14 12405541 Sleep. 2011 May;34(5):619-25 21532955 Neurology. 2003 Jul 8;61(1):40-5 12847154 Neurology. 2004 Jan 13;62(1):41-5 14718695 Neurology. 1999 Mar 23;52(5):951-7 10102411 Lancet Neurol. 2006 May;5(5):424-32 16632313 Lancet Neurol. 2006 Jul;5(7):572-7 16781987 Clin Neuropsychol. 2006 Dec;20

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2011 Sleep

164. Longitudinal Study of Cognitive Function in Idiopathic REM Sleep Behavior Disorder (PubMed)

Longitudinal Study of Cognitive Function in Idiopathic REM Sleep Behavior Disorder To assess the longitudinal course of cognitive functions in a cohort of patients with idiopathic REM sleep behavior disorder (iRBD).Prospective study with baseline and 2-year follow-up.Sleep disorders center.Twenty-four cognitively asymptomatic iRBD patients (18 M; mean age: 69.5 ± 7.3 y) and 12 sex-, age-, and education-matched healthy subjects.Participants underwent to a video-PSG, a focused neuropsychological

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2011 Sleep

165. Narcolepsy, REM Sleep Behavior Disorder, and Supranuclear Gaze Palsy Associated With Ma1 and Ma2 Antibodies and Tonsillar Carcinoma. (PubMed)

Narcolepsy, REM Sleep Behavior Disorder, and Supranuclear Gaze Palsy Associated With Ma1 and Ma2 Antibodies and Tonsillar Carcinoma. To describe a patient with diencephalic and mesencephalic presentation of a Ma1 and Ma2 antibody-associated paraneoplastic neurological disorder.Case report.The Colorado Neurological Institute Movement Disorders Center in Englewood, Colorado, and the Mayo Clinic in Rochester, Minnesota.A 55-year-old man with a paraneoplastic neurological disorder characterized (...) by rapid eye movement sleep behavior disorder, narcolepsy, and a progressive supranuclear palsy-like syndrome in the setting of tonsillar carcinoma.Immunotherapy for paraneoplastic neurological disorder, surgery and radiotherapy for cancer, and symptomatic treatment for parkinsonism and sleep disorders.Polysomnography, multiple sleep latency test, and neurological examination.The cancer was detected at a limited stage and treatable. After oncological therapy and immunotherapy, symptoms stabilized

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2011 Archives of Neurology

166. Validity of the Mattis Dementia Rating Scale to Detect Mild Cognitive Impairment in Parkinson's Disease and REM Sleep Behavior Disorder. (PubMed)

Validity of the Mattis Dementia Rating Scale to Detect Mild Cognitive Impairment in Parkinson's Disease and REM Sleep Behavior Disorder. Mild cognitive impairment (MCI) is frequent in Parkinson's disease (PD) and idiopathic REM sleep behavior disorder (iRBD). However, only a few studies have evaluated the validity of brief cognitive measures to detect MCI in PD or iRBD using standard diagnostic criteria for MCI. Our aim was to evaluate the validity of the Mini-Mental State Examination (MMSE

2011 Dementia and Geriatric Cognitive Disorders

167. Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder. (PubMed)

Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder. Recent studies have suggested a close connection between autonomic dysfunction and rapid eye movement sleep behavior disorder, which differs in nature from other early-stage markers of Parkinson's disease. In this study we examined the relationship between rapid eye movement sleep behavior disorder and autonomic dysfunction in Parkinson's disease as measured by cardiac beat-to-beat variability.In 53 (...) showed clear abnormalities compared with controls. However, these abnormalities were confined only to those patients with associated rapid eye movement sleep behavior; those without were not different than controls.As with other clinical autonomic variables, cardiac autonomic denervation is predominantly associated not with Parkinson's disease itself, but with the presence of rapid eye movement sleep behavior disorder.Copyright © 2011 Movement Disorder Society.

2011 Movement Disorders

168. A motor signature of REM sleep behavior disorder. (PubMed)

A motor signature of REM sleep behavior disorder. The purpose of this study was to determine if there was a common pattern in movements during REM sleep behavior disorder (RBD).We blindly compared video-monitored movements during RBD (n = 136 clips) and wakefulness/arousal (n = 53 clips) in patients with Parkinson's disease (n = 29) and without parkinsonism (idiopathic RBD, n = 31; narcolepsy, n = 5).The scorers accurately guessed the sleep/wake stage of 94% of video clips. Compared with wake (...) ), delineating a common motor signature of RBD.Copyright © 2011 Movement Disorder Society.

2011 Movement Disorders

169. Associated factors for REM sleep behavior disorder in Parkinson disease. (PubMed)

Associated factors for REM sleep behavior disorder in Parkinson disease. To investigate the frequency, phenomenology, and associated risk factors of REM sleep behavior disorder (RBD) in Parkinson disease (PD).An unselected cohort of sleep-disturbed patients with PD (n=457) was investigated with video-supported polysomnography. We determined the frequency of RBD and analyzed the influence of age, clinical disease features, disease duration, cognitive and physical impairment, medication (...) of levodopa (p=0.002). The presence of RBD was related to slightly increased sleep efficiency (p=0.007), a higher amount of REM sleep (p=0.000), and more periodic leg movements during sleep (p=0.019).RBD is a frequent and clinically relevant nocturnal disturbance for all stages of PD. It increases with age and disease duration and may contribute to the nocturnal problems of patients with PD and their bed partners.

2011 Neurology

170. Study to Determine Whether Ramelteon Helps People With REM Sleep Behavior Disorder

Study to Determine Whether Ramelteon Helps People With REM Sleep Behavior Disorder Study to Determine Whether Ramelteon Helps People With REM Sleep Behavior Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Study to Determine Whether Ramelteon Helps People With REM Sleep Behavior Disorder The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01401413 Recruitment Status : Completed First Posted : July 25, 2011 Last Update Posted : July 25, 2011 Sponsor: Sleep Medicine Centers of WNY Information

2011 Clinical Trials

171. The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder. (PubMed)

The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder. Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during paradoxical (REM) sleep (PS). Conversely, cataplexy, one of the key symptoms of narcolepsy, is a striking sudden episode of muscle weakness triggered by emotions during wakefulness, and comparable to REM sleep atonia. The neuronal

2011 Sleep medicine reviews

172. Sleep Disorders (PDQ®): Health Professional Version

, and/or hospitalization). Perception of significant others as to the quantity and quality of patient’s sleep. Family history of sleep disorders. References American Academy of Sleep Medicine: The International Classification of Sleep Disorders: Diagnostic & Coding Manual. 2nd ed. Westchester, Ill: American Academy of Sleep Medicine, 2005. Perlis ML, Jungquist C, Smith MT, et al.: Cognitive Behavioral Treatment of Insomnia: A Session-by-Session Guide. New York, NY: Springer Science+Business Media LLC, 2008. Bastien CH (...) ) 0.25–2 mg Used for REM sleep disorder (not FDA approved). [ ][ ] lorazepam (Ativan) 0.5–4 mg; dose >2 mg rare Risk of loss of motor coordination, falls, and cognitive impairment. [ ][ ] temazepam (Restoril) 7.5–30 mg Risk of loss of motor coordination, falls, and cognitive impairment. [ ][ ] Melatonin receptor agonist ramelteon (Rozerem) 8 mg Useful for problems falling asleep only. Little negative effect on cognition, somnolence, motor coordination, or nausea. [ ][ ] Antihistamine diphenhydramine

2016 PDQ - NCI's Comprehensive Cancer Database

173. Idiopathic rapid eye movement sleep behaviour disorder: a potential gateway to the development of disease-modifying treatments in neurodegenerative disorders (PubMed)

and Clinical Neuroscience, University Hospital of Wales, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK. Robertson N R NR Institute of Psychological Medicine and Clinical Neuroscience, University Hospital of Wales, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK. robertsonnp@cardiff.ac.uk. eng Journal Article Review Germany J Neurol 0423161 0340-5354 IM Aged Aged, 80 and over Female Humans Male Middle Aged Neurodegenerative Diseases complications therapy Polysomnography REM Sleep Behavior (...) Idiopathic rapid eye movement sleep behaviour disorder: a potential gateway to the development of disease-modifying treatments in neurodegenerative disorders 27416855 2017 04 11 2017 04 11 1432-1459 263 8 2016 Aug Journal of neurology J. Neurol. Idiopathic rapid eye movement sleep behaviour disorder: a potential gateway to the development of disease-modifying treatments in neurodegenerative disorders. 1678-80 10.1007/s00415-016-8235-8 Peall K J KJ Institute of Psychological Medicine

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2016 Journal of neurology

174. A Remotely Supervised Exercise Program for Lung Cancer Patients Undergoing Chemoradiation (REM)

and during chemoradiation. Condition or disease Intervention/treatment Phase Lung Cancer Behavioral: Remotely Supervised Exercise (REM) Behavioral: Unsupervised Exercise (UNSUP) Not Applicable Detailed Description: The research team adopts an overtly pragmatic approach where our design choices are made to enhance external validity and create a parsimonious intervention that can be integrated into busy clinical practices. This is a pilot study and is not designed to definitively provide evidence (...) that could occur in any setting: (1) enthusiastic provision on an exercise prescription and (2) provision of a fitness device (i.e., the Garmin VivioActive) that can help participants track their exercise engagement. Participants are instructed in how to use the device to track their adherence to the exercise prescription. Experimental: Remotely Supervised Exercise (REM) The REM program is designed to function as an Acceptance-based health coaching intervention and will utilize theory-based behavior

2018 Clinical Trials

175. Trauma associated sleep disorder: A parasomnia induced by trauma. (PubMed)

Trauma associated sleep disorder: A parasomnia induced by trauma. Nightmares and disruptive nocturnal behaviors that develop after traumatic experiences have long been recognized as having different clinical characteristics that overlap with other established parasomnia diagnoses. The inciting experience is typically in the setting of extreme traumatic stress coupled with periods of sleep disruption and/or deprivation. The limited number of laboratory documented cases and symptomatic overlap (...) with rapid eye movement sleep behavior disorder (RBD) and posttraumatic stress disorder (PTSD) have contributed to difficulties in identifying what is a unique parasomnia. Trauma associated sleep disorder (TSD) incorporates the inciting traumatic experience and clinical features of trauma related nightmares and disruptive nocturnal behaviors as a novel parasomnia. The aims of this theoretical review are to 1) summarize the known cases and clinical findings supporting TSD, 2) differentiate TSD from

2017 Sleep medicine reviews

176. The Role of the Circadian System in Neurological Sleep-wake Disorders

Sponsor: Esther Werth Information provided by (Responsible Party): Esther Werth, University of Zurich Study Details Study Description Go to Brief Summary: The aim of this study is to investigate the role of the circadian system in patients with neurologic sleep-wake disorders. Therefore, overnight sleep will be distributed over 30 hours into repetitive sleep-wake cycles (poly-nap protocol), so that sleep episodes occur at different circadian phases. Vigilance, attention, risk behavior as well as sleep (...) throughout our study protocol to explore better classification of sleep and wake phases and patterns of the rest-activity rhythm. This study is designed as an observational case-controlled study targeting the disorders of narcolepsy type 1 and idiopathic hypersomnia, and including interventional procedures in the healthy control group (sleep deprivation, sleep restriction) in a counter-balanced design. Condition or disease Intervention/treatment Phase Narcolepsy 1 Idiopathic Hypersomnia Behavioral: Sleep

2017 Clinical Trials

177. The Treatment of Sleep Disorders in Parkinson’s Disease: From Research to Clinical Practice (PubMed)

The Treatment of Sleep Disorders in Parkinson’s Disease: From Research to Clinical Practice Sleep disorders (SDs) are one of the most frequent non-motor symptoms of Parkinson's disease (PD), usually increasing in frequency over the course of the disease and disability progression. SDs include nocturnal and diurnal manifestations such as insomnia, REM sleep behavior disorder, and excessive daytime sleepiness. The causes of SDs in PD are numerous, including the neurodegeneration process itself (...) , which can disrupt the networks regulating the sleep-wake cycle and deplete a large number of cerebral amines possibly playing a role in the initiation and maintenance of sleep. Despite the significant prevalence of SDs in PD patients, few clinical trials on SDs treatment have been conducted. Our aim is to critically review the principal therapeutic options for the most common SDs in PD. The appropriate diagnosis and treatment of SDs in PD can lead to the consolidation of nocturnal sleep

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2017 Frontiers in neurology

178. An under-diagnosed geriatric syndrome: sleep disorders among older adults (PubMed)

, Rapid eye movement (REM) sleep behavior disorder (RBD) Single-Question Screen questionnaire (RBD1Q) and The Johns Hopkins Restless Leg Syndrome Severity Scale. Demographic and clinical data including age, sex, medications, comorbid diseases, body mass index and functional scores was noted.The mean age of the patients was 80.92±4.3 years. 35.5% of the patients had findings of REM-SBD and 32.5% of the patients had restless legs syndrome. Ninety-seven percent of the patients answered 'yes' to at least (...) An under-diagnosed geriatric syndrome: sleep disorders among older adults Sleep disorders are commonly under-diagnosed in the geriatric population. We aimed to determine the prevalence of sleep problems among older adults admitted to the geriatrics out-patient clinic.Two hundred and three patients (136 female) older than 75 years of age were included in the study. Patients underwent comprehensive geriatric assessment, including identification of sleep problems using the Sleep Disturbance Scale

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2017 African health sciences

179. Motor Control During Rapid Eye Movement (REM) Sleep Behaviour Disorder

: Layout table for MeSH terms Parkinson Disease Mental Disorders REM Sleep Behavior Disorder Parkinsonian Disorders Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Nervous System Diseases Movement Disorders Neurodegenerative Diseases REM Sleep Parasomnias Parasomnias Sleep Wake Disorders (...) Motor Control During Rapid Eye Movement (REM) Sleep Behaviour Disorder Motor Control During Rapid Eye Movement (REM) Sleep Behaviour Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Motor Control

2013 Clinical Trials

180. Slow oscillating transcranial direct current stimulation during non-rapid eye movement sleep improves behavioral inhibition in attention-deficit/hyperactivity disorder. (PubMed)

Slow oscillating transcranial direct current stimulation during non-rapid eye movement sleep improves behavioral inhibition in attention-deficit/hyperactivity disorder. Behavioral inhibition, which is a later-developing executive function (EF) and anatomically located in prefrontal areas, is impaired in attention-deficit and hyperactivity disorder (ADHD). While optimal EFs have been shown to depend on efficient sleep in healthy subjects, the impact of sleep problems, frequently reported in ADHD (...) stimulation (so-tDCS, frequency = 0.75 Hz) during non-REM sleep, we aimed to improve daytime behavioral inhibition in children with ADHD.Fourteen boys (10-14 years) diagnosed with ADHD were included. In a randomized, double-blind, cross-over design, patients received so-tDCS either in the first or in the second experimental sleep night. Inhibition control was assessed with a visuomotor go/no-go task. Intrinsic alertness was assessed with a simple stimulus response task. To control for visuomotor

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2015 Frontiers in cellular neuroscience

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