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REM Sleep Behavior Disorder

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161. Unimpaired postprandial pancreatic polypeptide secretion in Parkinson's disease and REM sleep behavior disorder. (Abstract)

Unimpaired postprandial pancreatic polypeptide secretion in Parkinson's disease and REM sleep behavior disorder. Pancreatic polypeptide is released immediately after food ingestion. The release is operated by vagal-abdominal projections and has therefore been suggested as a test for vagal nerve integrity. Pathoanatomical and clinical studies indicate vagal dysfunction in early Parkinson's disease (PD).We assessed the postprandial secretion of pancreatic polypeptide and motilin in healthy (...) controls (n = 18) and patients with idiopathic rapid-eye-movement sleep behavior disorder (iRBD, n = 10), a potential premotor stage of PD, as well as in drug-naive (n = 19) and treated (n = 19) PD patients.The postprandial pancreatic polypeptide secretion showed a physiological pattern in all groups and even an enhanced response in drug-naive PD and iRBD. Motilin concentrations correlated with pancreatic polypeptide concentrations.Postprandial pancreatic polypeptide secretion is not a suitable test

2012 Movement Disorders

162. How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder. Full Text available with Trip Pro

directly the development of parkinsonism. Patients with idiopathic REM sleep behaviour disorder in an ongoing cohort study were evaluated annually with several quantitative motor measures, including the Unified Parkinson's Disease Rating Scale, Purdue Pegboard, alternate-tap test and timed up-and-go. Patients who developed parkinsonism were identified from this cohort and matched according to age to normal controls. Their results on motor testing from the preceding years were plotted, and then assessed (...) ' REM sleep behaviour disorder demonstrated evidence of possible prodromal parkinsonism. Therefore, using direct assessment of motor examination before parkinsonism in a REM sleep behaviour disorder, we have estimated a prodromal interval of ∼4.5 years on the Unified Parkinson's Disease Rating Scale; other quantitative markers may detect parkinsonism earlier. Simple quantitative motor measures may be capable of reliably detecting parkinsonism, even before a clinical diagnosis can be made

2012 Brain

163. Sleep Behavior and Hip/Knee Prosthesis

Ortopedico Galeazzi Study Details Study Description Go to Brief Summary: The consequences of chronically insufficient sleep are both behavioral and medical. . Patients who undergo total knee or hip arthroplasty commonly complain of sleep fragmentation after hospitalization The aim of the present study is to evaluate the changes in objective and subjective sleep quality and perceived pain, untill the 10th hospitalization day, in patients who underwent total knee or hip arthroplasty. Condition or disease (...) and quality of sleep represent important factors for the quality of life, which can have positive or negative influence on individual health (2-4). Patients who undergo total knee or hip arthroplasty commonly complain of sleep fragmentation after hospitalization (5,6) Such patients experience acute postsurgical pain and discomfort, including restriction of their leg movement to prevent dislocation of the hip implant in the acute stage. The results of previous post-surgery studies have shown that REM sleep

2018 Clinical Trials

164. Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American Academy of Sleep Medicine clinical practice guideline.

, hypoventilation and sleep related hypoxemia). Examples of these conditions include significant cardiopulmonary disease, potential respiratory muscle weakness due to neuromuscular conditions, history of stroke and chronic opiate medication use. Concern for significant non-respiratory sleep disorder(s) that require evaluation (e.g., disorders of central hypersomnolence, parasomnias, sleep related movement disorders) or interfere with accuracy of HSAT (e.g., severe insomnia). Environmental or personal factors (...) . ( Strong ) Recommendation 3 : The TF recommends that if a single home sleep apnea test is negative, inconclusive or technically inadequate, polysomnography be performed for the diagnosis of OSA. ( Strong ) Remarks : The following remarks are based on specifications used by studies that support these recommendation statements: An uncomplicated patient is defined by the absence of: Conditions that place the patient at increased risk of non-obstructive sleep-disordered breathing (e.g., central sleep apnea

2017 National Guideline Clearinghouse (partial archive)

165. Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline

with OSA can also have other sleep disorders that may be related to or unrelated to OSA. Comorbid insomnia has been found to be a frequent problem in patients with OSA. It is also possible that undiagnosed OSA may be masquerading as another sleep disorder, such as REM Behavior Disorder. Therefore, when OSA is suspected, a comprehensive sleep evaluation is important to ensure appropriate diagnostic testing is performed to address OSA, as well as other comorbid sleep complaints. The diagnosis of OSA (...) apnea test is negative, inconclusive, or technically inadequate, polysomnography be performed for the diagnosis of OSA. (STRONG) We recommend that polysomnography, rather than home sleep apnea testing, be used for the diagnosis of OSA in patients with significant cardiorespiratory disease, potential respiratory muscle weakness due to neuromuscular condition, awake hypoventilation or suspicion of sleep related hypoventilation, chronic opioid medication use, history of stroke or severe insomnia

2017 American Academy of Sleep Medicine

166. REM Sleep Behavior Disorder

) Definition (MSH) A disorder characterized by episodes of vigorous and often violent motor activity during REM sleep (SLEEP, REM). The affected individual may inflict self injury or harm others, and is difficult to awaken from this condition. Episodes are usually followed by a vivid recollection of a dream that is consistent with the aggressive behavior. This condition primarily affects adult males. (From Adams et al., Principles of Neurology, 6th ed, p393) Concepts Disease or Syndrome ( T047 ) MSH ICD9 (...) Sleep Behavior Disorder , REM sleep behavior dis , REM Sleep Behavior Disorder [Disease/Finding] , rem sleep behavior disorder , rem behavior sleep disorder , behavior disorders rem sleep , rem behavior disorder , REM sleep behavior disorder (diagnosis) , sleep disorder rem sleep behavior , REM sleep behavior disorder , REM sleep behaviour disorder , REM sleep disorder , Rapid eye movement sleep behavior disorder (disorder) , Rapid eye movement sleep behavior disorder , Rapid eye movement sleep

2015 FP Notebook

167. Parasomnia Overlap Disorder with Sexual Behaviors during Sleep in a Patient with Obstructive Sleep Apnea Full Text available with Trip Pro

, sleeptalking, and REM sleep behavior disorder (RBD). Confusional arousals and RBD were documented during the vPSG. This case had the added complexity of obstructive sleep apnea (OSA) playing a role in sleepwalking and sleep related eating, with good response to nasal continuous positive airway pressure (nCPAP). The sexsomnia did not respond to nCPAP but responded substantially to bedtime clonazepam therapy.© 2016 American Academy of Sleep Medicine. (...) Parasomnia Overlap Disorder with Sexual Behaviors during Sleep in a Patient with Obstructive Sleep Apnea Sleep-related abnormal sexual behaviors (sexsomnia) are classified as a subtype of NREM sleep parasomnias. Sexsomnia has been reported as part of parasomnia overlap disorder (POD) in two other patients. We present the case of a 42-year-old male patient with video-polysomnography (vPSG) documented POD. The patient had sleepwalking, sleep-related eating, confusional arousals, sexsomnia

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

168. Hiding in plain sight: Risk factors for REM sleep behavior disorder. Full Text available with Trip Pro

Hiding in plain sight: Risk factors for REM sleep behavior disorder. 22744669 2012 10 12 2018 12 01 1526-632X 79 5 2012 Jul 31 Neurology Neurology Hiding in plain sight: risk factors for REM sleep behavior disorder. 402-3 10.1212/WNL.0b013e31825dd3c0 Sullivan Shannon S SS Schenck Carlos H CH Guilleminault Christian C eng Editorial Comment 2012 06 27 United States Neurology 0401060 0028-3878 AIM IM Neurology. 2012 Jul 31;79(5):428-34 22744670 Environment Female Humans Life Style Male REM Sleep (...) Behavior Disorder etiology 2012 6 30 6 0 2012 6 30 6 0 2012 10 13 6 0 ppublish 22744669 WNL.0b013e31825dd3c0 10.1212/WNL.0b013e31825dd3c0

2012 Neurology

169. Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study. Full Text available with Trip Pro

Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study. Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder.Cases were patients with idiopathic REM sleep behavior disorder who were free (...) of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors.A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0% were

2012 Neurology

170. Validation of the Innsbruck REM sleep behavior disorder inventory. (Abstract)

Validation of the Innsbruck REM sleep behavior disorder inventory. A diagnosis of definite REM sleep behavior disorder requires both a positive history for REM sleep behavior disorder and polysomnographic demonstration of REM sleep without atonia. To improve and facilitate screening for REM sleep behavior disorder, there is a need for simple clinical tools with sufficient sensitivity and specificity for the identification of subjects with probable REM sleep behavior disorder. We developed (...) a short REM sleep behavior disorder screening questionnaire with 7 REM sleep behavior disorder- and 2 non-REM sleep behavior disorder-specific control items and performed a validation study in 70 REM sleep behavior disorder subjects and 140 sleep disorder controls. Response patterns to all 7 REM sleep behavior disorder-specific items differed between REM sleep behavior disorder and non-REM sleep behavior disorder patients (all P < 0.05), whereas the 2 non-REM sleep behavior disorder-specific control

2012 Movement Disorders

171. REM sleep behavior disorder: Motor manifestations and pathophysiology. (Abstract)

REM sleep behavior disorder: Motor manifestations and pathophysiology. Patients with REM sleep behavior disorder (RBD) enact violent dreams during REM sleep in the absence of normal muscle atonia. This disorder is highly frequent in patients with synucleinopathies (60%-100% of patients) and rare in patients with other neurodegenerative disorders. The disorder is detected by interview plus video and sleep monitoring. Abnormal movements expose the patients and bed partners to a high risk (...) of injury and sleep disruption. The disorder is usually alleviated with melatonin and clonazepam. Limb movements are mainly minor, jerky, fast, pseudohallucinatory, and repeated, with a limp wrist during apparently grasping movements, although body jerks and complex violent (fights) and nonviolent culturally acquired behaviors are also observed. Notably, parkinsonism disappears during RBD-associated complex behaviors in patients with Parkinson's disease and with multiple system atrophy, suggesting

2012 Movement Disorders

172. Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder. (Abstract)

Article 2012 12 12 United States Neurology 0401060 0028-3878 Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant AIM IM Brain Waves physiology Humans Magnetic Resonance Imaging methods psychology Male Middle Aged Pelizaeus-Merzbacher Disease complications diagnosis physiopathology Polysomnography methods psychology REM Sleep Behavior Disorder complications diagnosis physiopathology 2012 12 18 6 0 2012 12 18 6 0 2013 2 26 6 0 ppublish 23243074 WNL.0b013e31827b1b2a 10.1212/WNL (...) Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder. 23243074 2013 02 25 2012 12 25 1526-632X 80 1 2013 Jan 01 Neurology Neurology Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder. 118-20 10.1212/WNL.0b013e31827b1b2a Flanagan Eoin P EP Department of Neurology, Mayo Clinic, Rochester, MN, USA. Gavrilova Ralitza H RH Boeve Bradley F BF Kumar Neeraj N Jelsing Elena J EJ Silber Michael H MH eng Case Reports Journal

2012 Neurology

173. Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder. Full Text available with Trip Pro

Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder. Patients with idiopathic REM sleep behavior disorder (IRBD) are at risk for developing Parkinson disease (PD) and dementia with Lewy bodies (DLB). We aimed to identify functional brain imaging patterns predicting the emergence of PD and DLB in patients with IRBD, using SPECT with (99m)Tc-ethylene cysteinate dimer (ECD).Twenty patients with IRBD were scanned at baseline during wakefulness using (99m)Tc-ECD (...) in this process.Of the 20 patients with IRBD recruited for this study, 10 converted to PD or DLB during the follow-up. rCBF at baseline was increased in the hippocampus of patients who would later convert compared with those who would not (p < 0.05 corrected). Hippocampal perfusion was correlated with motor and color vision scores across all IRBD patients.(99m)Tc-ECD SPECT identifies patients with IRBD at risk for conversion to other neurodegenerative disorders such as PD or DLB; disease progression in IRBD

2012 Neurology

174. Characteristics of REM Sleep Behavior Disorder in Childhood Full Text available with Trip Pro

Characteristics of REM Sleep Behavior Disorder in Childhood To describe our experience regarding the clinical and polysomnographic features of REM sleep behavior disorder (RBD) in childhood.This was a retrospective chart review of children and adolescents with RBD and REM sleep without atonia. Demographics, and clinical and polysomnographic information were tabulated. Our findings were compared with those in the existing literature.The 15 subjects identified (13 RBD and 2 having REM sleep (...) ), and Moebius Syndrome (1/15). Abnormal MRI scans were seen in 5/8 evaluated subjects. Treatments consisted of clonazepam (10/15), melatonin (2/15), and discontinuation of a tricyclic agent (1/15), with a favorable response in 11 of 13. Two of 15 patients with REM sleep without atonia did not require pharmacotherapy.RBD in children may be associated with neurodevelopmental disabilities, narcolepsy, or medication use. It seems to be modestly responsive to benzodiazepines or melatonin. The etiology

2012 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

175. Understanding the Natural History of REM Sleep Behavior Disorder

to prevent, delay, or slow the development of one of more of these diseases. Some people with REM sleep behavior disorder (RBD) may go on to develop Parkinson's disease or another related neurological disorder, but many do not. Condition or disease REM Sleep Behavior Disorder Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 15 participants Observational Model: Case-Only Time Perspective: Cross-Sectional Official Title: Understanding Autonomic (...) Posted: August 29, 2012 Last Update Posted: August 29, 2012 Last Verified: August 2012 Keywords provided by J. William Langston, The Parkinson's Institute: REM Sleep Behavior Disorder RBD Dream Dreams Additional relevant MeSH terms: Layout table for MeSH terms Disease Mental Disorders REM Sleep Behavior Disorder Pathologic Processes REM Sleep Parasomnias Parasomnias Sleep Wake Disorders Nervous System Diseases

2012 Clinical Trials

176. Sleep disorders and Parkinson disease; lessons from genetics. (Abstract)

during its prodromal phase. However, with the exception of REM sleep behavior disorder, it is unclear whether they are part of the early pathological process of Parkinson disease, or if they develop as Parkinson disease advances because of treatments and neurodegeneration progression. The advancements in genetic studies in the past two decades have generated a wealth of information, and recent genetic studies offer new insight on the association of sleep-related disorders with Parkinson disease. More (...) Sleep disorders and Parkinson disease; lessons from genetics. Parkinson disease is a common, age-related neurodegenerative disorder, projected to afflict millions of individuals in the near future. Understanding its etiology and identifying clinical, genetic or biological markers for Parkinson disease onset and progression is therefore of major importance. Various sleep-related disorders are the most common group of non-motor symptoms in advanced Parkinson disease, but they can also occur

2018 Sleep medicine reviews

177. Sleep-related Eating Disorder in a Patient with Parkinson's Disease Full Text available with Trip Pro

Sleep-related Eating Disorder in a Patient with Parkinson's Disease Sleep disorders constitute a major aspect of the non-motor symptoms of Parkinson's disease (PD). Rapid eye movement (REM) behavior disorders are the most frequently experienced parasomnias in patients with PD. Non-REM sleep disorders like confusional arousals, sleep terrors, sleepwalking, and sleep-related eating disorder (SRED) are also associated with PD. Parasomnias can affect the quality of life of the patients as well (...) as the night time sleep of their bed partners. Hence, it is important for physicians to recognize the occurrence of parasomnias in PD. We report an unusual case of PD with SRED along with obstructive sleep apnea (OSA) and REM behavior disorder. To our knowledge, only two cases have been reported in the literature highlighting the association of SRED with PD. We also explain the different night-time eating disorders like nocturnal eating syndrome and binge eating syndrome, which can be seen in PD

2018 Cureus

178. Surface EMG activity during REM sleep in Parkinson’s disease correlates with disease severity Full Text available with Trip Pro

Surface EMG activity during REM sleep in Parkinson’s disease correlates with disease severity Over 40% of individuals with Parkinson's disease (PD) have rapid eye movement sleep behavior disorder (RBD). This is associated with excessive sustained (tonic) or intermittent (phasic) muscle activity instead of the muscle atonia normally seen during REM sleep. We examined characteristics of manually-quantitated surface EMG activity in PD to ascertain whether the extent of muscle activity during REM (...) sleep is associated with specific clinical features and measures of disease severity.In a convenience sample of outpatients with idiopathic PD, REM sleep behavior disorder was diagnosed based on clinical history and polysomnogram, and severity was measured using the RBD sleep questionnaire. Surface EMG activity in the mentalis, extensor muscle group of the forearms, and anterior tibialis was manually quantitated. Percentage of REM time with excessive tonic or phasic muscle activity was calculated

2014 Parkinsonism & related disorders

179. Long-Term Follow-up Investigation of Isolated Rapid Eye Movement Sleep Without Atonia Without Rapid Eye Movement Sleep Behavior Disorder: A Pilot Study Full Text available with Trip Pro

Long-Term Follow-up Investigation of Isolated Rapid Eye Movement Sleep Without Atonia Without Rapid Eye Movement Sleep Behavior Disorder: A Pilot Study Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a harbinger of synuclein-mediated neurodegenerative diseases. It is unknown if this also applies to isolated REM sleep without atonia (RWA). We performed a long-term follow-up investigation of subjects with isolated RWA.Participants were recruited from 50 subjects with isolated (...) of synuclein-mediated neurodegeneration. These results will have to be replicated in larger studies with longer observational periods. If confirmed, these disease findings have implications for defining at-risk cohorts for Parkinson disease.© 2015 American Academy of Sleep Medicine.

2015 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

180. Beyond factor analysis: Multidimensionality and the Parkinson's Disease Sleep Scale-Revised. Full Text available with Trip Pro

data collected using the PDSS-R as an exemplar. 166 participants diagnosed with idiopathic PD participated in this study. Using PDSS-R data, we compared three models: a unidimensional model; a 3-factor model consisting of sub-factors measuring insomnia, motor symptoms and obstructive sleep apnoea (OSA) and REM sleep behaviour disorder (RBD) symptoms; and, a confirmatory bifactor model with both a general factor and the same three sub-factors. Only the confirmatory bifactor model achieved (...) Beyond factor analysis: Multidimensionality and the Parkinson's Disease Sleep Scale-Revised. Many studies have sought to describe the relationship between sleep disturbance and cognition in Parkinson's disease (PD). The Parkinson's Disease Sleep Scale (PDSS) and its variants (the Parkinson's disease Sleep Scale-Revised; PDSS-R, and the Parkinson's Disease Sleep Scale-2; PDSS-2) quantify a range of symptoms impacting sleep in only 15 items. However, data from these scales may be problematic

2018 PLoS ONE

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