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REM Sleep Behavior Disorder

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161. Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American Academy of Sleep Medicine clinical practice guideline.

, hypoventilation and sleep related hypoxemia). Examples of these conditions include significant cardiopulmonary disease, potential respiratory muscle weakness due to neuromuscular conditions, history of stroke and chronic opiate medication use. Concern for significant non-respiratory sleep disorder(s) that require evaluation (e.g., disorders of central hypersomnolence, parasomnias, sleep related movement disorders) or interfere with accuracy of HSAT (e.g., severe insomnia). Environmental or personal factors (...) . ( Strong ) Recommendation 3 : The TF recommends that if a single home sleep apnea test is negative, inconclusive or technically inadequate, polysomnography be performed for the diagnosis of OSA. ( Strong ) Remarks : The following remarks are based on specifications used by studies that support these recommendation statements: An uncomplicated patient is defined by the absence of: Conditions that place the patient at increased risk of non-obstructive sleep-disordered breathing (e.g., central sleep apnea

2017 National Guideline Clearinghouse (partial archive)

162. Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline

with OSA can also have other sleep disorders that may be related to or unrelated to OSA. Comorbid insomnia has been found to be a frequent problem in patients with OSA. It is also possible that undiagnosed OSA may be masquerading as another sleep disorder, such as REM Behavior Disorder. Therefore, when OSA is suspected, a comprehensive sleep evaluation is important to ensure appropriate diagnostic testing is performed to address OSA, as well as other comorbid sleep complaints. The diagnosis of OSA (...) apnea test is negative, inconclusive, or technically inadequate, polysomnography be performed for the diagnosis of OSA. (STRONG) We recommend that polysomnography, rather than home sleep apnea testing, be used for the diagnosis of OSA in patients with significant cardiorespiratory disease, potential respiratory muscle weakness due to neuromuscular condition, awake hypoventilation or suspicion of sleep related hypoventilation, chronic opioid medication use, history of stroke or severe insomnia

2017 American Academy of Sleep Medicine

163. REM Sleep Behavior Disorder

) Definition (MSH) A disorder characterized by episodes of vigorous and often violent motor activity during REM sleep (SLEEP, REM). The affected individual may inflict self injury or harm others, and is difficult to awaken from this condition. Episodes are usually followed by a vivid recollection of a dream that is consistent with the aggressive behavior. This condition primarily affects adult males. (From Adams et al., Principles of Neurology, 6th ed, p393) Concepts Disease or Syndrome ( T047 ) MSH ICD9 (...) Sleep Behavior Disorder , REM sleep behavior dis , REM Sleep Behavior Disorder [Disease/Finding] , rem sleep behavior disorder , rem behavior sleep disorder , behavior disorders rem sleep , rem behavior disorder , REM sleep behavior disorder (diagnosis) , sleep disorder rem sleep behavior , REM sleep behavior disorder , REM sleep behaviour disorder , REM sleep disorder , Rapid eye movement sleep behavior disorder (disorder) , Rapid eye movement sleep behavior disorder , Rapid eye movement sleep

2015 FP Notebook

164. Parasomnia Overlap Disorder with Sexual Behaviors during Sleep in a Patient with Obstructive Sleep Apnea Full Text available with Trip Pro

, sleeptalking, and REM sleep behavior disorder (RBD). Confusional arousals and RBD were documented during the vPSG. This case had the added complexity of obstructive sleep apnea (OSA) playing a role in sleepwalking and sleep related eating, with good response to nasal continuous positive airway pressure (nCPAP). The sexsomnia did not respond to nCPAP but responded substantially to bedtime clonazepam therapy.© 2016 American Academy of Sleep Medicine. (...) Parasomnia Overlap Disorder with Sexual Behaviors during Sleep in a Patient with Obstructive Sleep Apnea Sleep-related abnormal sexual behaviors (sexsomnia) are classified as a subtype of NREM sleep parasomnias. Sexsomnia has been reported as part of parasomnia overlap disorder (POD) in two other patients. We present the case of a 42-year-old male patient with video-polysomnography (vPSG) documented POD. The patient had sleepwalking, sleep-related eating, confusional arousals, sexsomnia

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

165. Understanding the Natural History of REM Sleep Behavior Disorder

to prevent, delay, or slow the development of one of more of these diseases. Some people with REM sleep behavior disorder (RBD) may go on to develop Parkinson's disease or another related neurological disorder, but many do not. Condition or disease REM Sleep Behavior Disorder Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 15 participants Observational Model: Case-Only Time Perspective: Cross-Sectional Official Title: Understanding Autonomic (...) Posted: August 29, 2012 Last Update Posted: August 29, 2012 Last Verified: August 2012 Keywords provided by J. William Langston, The Parkinson's Institute: REM Sleep Behavior Disorder RBD Dream Dreams Additional relevant MeSH terms: Layout table for MeSH terms Disease Mental Disorders REM Sleep Behavior Disorder Pathologic Processes REM Sleep Parasomnias Parasomnias Sleep Wake Disorders Nervous System Diseases

2012 Clinical Trials

166. Characteristics of REM Sleep Behavior Disorder in Childhood Full Text available with Trip Pro

Characteristics of REM Sleep Behavior Disorder in Childhood To describe our experience regarding the clinical and polysomnographic features of REM sleep behavior disorder (RBD) in childhood.This was a retrospective chart review of children and adolescents with RBD and REM sleep without atonia. Demographics, and clinical and polysomnographic information were tabulated. Our findings were compared with those in the existing literature.The 15 subjects identified (13 RBD and 2 having REM sleep (...) ), and Moebius Syndrome (1/15). Abnormal MRI scans were seen in 5/8 evaluated subjects. Treatments consisted of clonazepam (10/15), melatonin (2/15), and discontinuation of a tricyclic agent (1/15), with a favorable response in 11 of 13. Two of 15 patients with REM sleep without atonia did not require pharmacotherapy.RBD in children may be associated with neurodevelopmental disabilities, narcolepsy, or medication use. It seems to be modestly responsive to benzodiazepines or melatonin. The etiology

2012 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

167. Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder. (Abstract)

Article 2012 12 12 United States Neurology 0401060 0028-3878 Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant AIM IM Brain Waves physiology Humans Magnetic Resonance Imaging methods psychology Male Middle Aged Pelizaeus-Merzbacher Disease complications diagnosis physiopathology Polysomnography methods psychology REM Sleep Behavior Disorder complications diagnosis physiopathology 2012 12 18 6 0 2012 12 18 6 0 2013 2 26 6 0 ppublish 23243074 WNL.0b013e31827b1b2a 10.1212/WNL (...) Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder. 23243074 2013 02 25 2012 12 25 1526-632X 80 1 2013 Jan 01 Neurology Neurology Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder. 118-20 10.1212/WNL.0b013e31827b1b2a Flanagan Eoin P EP Department of Neurology, Mayo Clinic, Rochester, MN, USA. Gavrilova Ralitza H RH Boeve Bradley F BF Kumar Neeraj N Jelsing Elena J EJ Silber Michael H MH eng Case Reports Journal

2012 Neurology

168. Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder. Full Text available with Trip Pro

Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder. Patients with idiopathic REM sleep behavior disorder (IRBD) are at risk for developing Parkinson disease (PD) and dementia with Lewy bodies (DLB). We aimed to identify functional brain imaging patterns predicting the emergence of PD and DLB in patients with IRBD, using SPECT with (99m)Tc-ethylene cysteinate dimer (ECD).Twenty patients with IRBD were scanned at baseline during wakefulness using (99m)Tc-ECD (...) in this process.Of the 20 patients with IRBD recruited for this study, 10 converted to PD or DLB during the follow-up. rCBF at baseline was increased in the hippocampus of patients who would later convert compared with those who would not (p < 0.05 corrected). Hippocampal perfusion was correlated with motor and color vision scores across all IRBD patients.(99m)Tc-ECD SPECT identifies patients with IRBD at risk for conversion to other neurodegenerative disorders such as PD or DLB; disease progression in IRBD

2012 Neurology

169. Validation of the Innsbruck REM sleep behavior disorder inventory. (Abstract)

Validation of the Innsbruck REM sleep behavior disorder inventory. A diagnosis of definite REM sleep behavior disorder requires both a positive history for REM sleep behavior disorder and polysomnographic demonstration of REM sleep without atonia. To improve and facilitate screening for REM sleep behavior disorder, there is a need for simple clinical tools with sufficient sensitivity and specificity for the identification of subjects with probable REM sleep behavior disorder. We developed (...) a short REM sleep behavior disorder screening questionnaire with 7 REM sleep behavior disorder- and 2 non-REM sleep behavior disorder-specific control items and performed a validation study in 70 REM sleep behavior disorder subjects and 140 sleep disorder controls. Response patterns to all 7 REM sleep behavior disorder-specific items differed between REM sleep behavior disorder and non-REM sleep behavior disorder patients (all P < 0.05), whereas the 2 non-REM sleep behavior disorder-specific control

2012 Movement Disorders

170. Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study. Full Text available with Trip Pro

Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study. Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder.Cases were patients with idiopathic REM sleep behavior disorder who were free (...) of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors.A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0% were

2012 Neurology

171. Hiding in plain sight: Risk factors for REM sleep behavior disorder. Full Text available with Trip Pro

Hiding in plain sight: Risk factors for REM sleep behavior disorder. 22744669 2012 10 12 2018 12 01 1526-632X 79 5 2012 Jul 31 Neurology Neurology Hiding in plain sight: risk factors for REM sleep behavior disorder. 402-3 10.1212/WNL.0b013e31825dd3c0 Sullivan Shannon S SS Schenck Carlos H CH Guilleminault Christian C eng Editorial Comment 2012 06 27 United States Neurology 0401060 0028-3878 AIM IM Neurology. 2012 Jul 31;79(5):428-34 22744670 Environment Female Humans Life Style Male REM Sleep (...) Behavior Disorder etiology 2012 6 30 6 0 2012 6 30 6 0 2012 10 13 6 0 ppublish 22744669 WNL.0b013e31825dd3c0 10.1212/WNL.0b013e31825dd3c0

2012 Neurology

172. REM sleep behavior disorder: Motor manifestations and pathophysiology. (Abstract)

REM sleep behavior disorder: Motor manifestations and pathophysiology. Patients with REM sleep behavior disorder (RBD) enact violent dreams during REM sleep in the absence of normal muscle atonia. This disorder is highly frequent in patients with synucleinopathies (60%-100% of patients) and rare in patients with other neurodegenerative disorders. The disorder is detected by interview plus video and sleep monitoring. Abnormal movements expose the patients and bed partners to a high risk (...) of injury and sleep disruption. The disorder is usually alleviated with melatonin and clonazepam. Limb movements are mainly minor, jerky, fast, pseudohallucinatory, and repeated, with a limp wrist during apparently grasping movements, although body jerks and complex violent (fights) and nonviolent culturally acquired behaviors are also observed. Notably, parkinsonism disappears during RBD-associated complex behaviors in patients with Parkinson's disease and with multiple system atrophy, suggesting

2012 Movement Disorders

173. Sleep disorders and Parkinson disease; lessons from genetics. (Abstract)

during its prodromal phase. However, with the exception of REM sleep behavior disorder, it is unclear whether they are part of the early pathological process of Parkinson disease, or if they develop as Parkinson disease advances because of treatments and neurodegeneration progression. The advancements in genetic studies in the past two decades have generated a wealth of information, and recent genetic studies offer new insight on the association of sleep-related disorders with Parkinson disease. More (...) Sleep disorders and Parkinson disease; lessons from genetics. Parkinson disease is a common, age-related neurodegenerative disorder, projected to afflict millions of individuals in the near future. Understanding its etiology and identifying clinical, genetic or biological markers for Parkinson disease onset and progression is therefore of major importance. Various sleep-related disorders are the most common group of non-motor symptoms in advanced Parkinson disease, but they can also occur

2018 Sleep medicine reviews

174. Sleep-related Eating Disorder in a Patient with Parkinson's Disease Full Text available with Trip Pro

Sleep-related Eating Disorder in a Patient with Parkinson's Disease Sleep disorders constitute a major aspect of the non-motor symptoms of Parkinson's disease (PD). Rapid eye movement (REM) behavior disorders are the most frequently experienced parasomnias in patients with PD. Non-REM sleep disorders like confusional arousals, sleep terrors, sleepwalking, and sleep-related eating disorder (SRED) are also associated with PD. Parasomnias can affect the quality of life of the patients as well (...) as the night time sleep of their bed partners. Hence, it is important for physicians to recognize the occurrence of parasomnias in PD. We report an unusual case of PD with SRED along with obstructive sleep apnea (OSA) and REM behavior disorder. To our knowledge, only two cases have been reported in the literature highlighting the association of SRED with PD. We also explain the different night-time eating disorders like nocturnal eating syndrome and binge eating syndrome, which can be seen in PD

2018 Cureus

175. Surface EMG activity during REM sleep in Parkinson’s disease correlates with disease severity Full Text available with Trip Pro

Surface EMG activity during REM sleep in Parkinson’s disease correlates with disease severity Over 40% of individuals with Parkinson's disease (PD) have rapid eye movement sleep behavior disorder (RBD). This is associated with excessive sustained (tonic) or intermittent (phasic) muscle activity instead of the muscle atonia normally seen during REM sleep. We examined characteristics of manually-quantitated surface EMG activity in PD to ascertain whether the extent of muscle activity during REM (...) sleep is associated with specific clinical features and measures of disease severity.In a convenience sample of outpatients with idiopathic PD, REM sleep behavior disorder was diagnosed based on clinical history and polysomnogram, and severity was measured using the RBD sleep questionnaire. Surface EMG activity in the mentalis, extensor muscle group of the forearms, and anterior tibialis was manually quantitated. Percentage of REM time with excessive tonic or phasic muscle activity was calculated

2014 Parkinsonism & related disorders

176. Long-Term Follow-up Investigation of Isolated Rapid Eye Movement Sleep Without Atonia Without Rapid Eye Movement Sleep Behavior Disorder: A Pilot Study Full Text available with Trip Pro

Long-Term Follow-up Investigation of Isolated Rapid Eye Movement Sleep Without Atonia Without Rapid Eye Movement Sleep Behavior Disorder: A Pilot Study Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a harbinger of synuclein-mediated neurodegenerative diseases. It is unknown if this also applies to isolated REM sleep without atonia (RWA). We performed a long-term follow-up investigation of subjects with isolated RWA.Participants were recruited from 50 subjects with isolated (...) of synuclein-mediated neurodegeneration. These results will have to be replicated in larger studies with longer observational periods. If confirmed, these disease findings have implications for defining at-risk cohorts for Parkinson disease.© 2015 American Academy of Sleep Medicine.

2015 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

177. Beyond factor analysis: Multidimensionality and the Parkinson's Disease Sleep Scale-Revised. Full Text available with Trip Pro

data collected using the PDSS-R as an exemplar. 166 participants diagnosed with idiopathic PD participated in this study. Using PDSS-R data, we compared three models: a unidimensional model; a 3-factor model consisting of sub-factors measuring insomnia, motor symptoms and obstructive sleep apnoea (OSA) and REM sleep behaviour disorder (RBD) symptoms; and, a confirmatory bifactor model with both a general factor and the same three sub-factors. Only the confirmatory bifactor model achieved (...) Beyond factor analysis: Multidimensionality and the Parkinson's Disease Sleep Scale-Revised. Many studies have sought to describe the relationship between sleep disturbance and cognition in Parkinson's disease (PD). The Parkinson's Disease Sleep Scale (PDSS) and its variants (the Parkinson's disease Sleep Scale-Revised; PDSS-R, and the Parkinson's Disease Sleep Scale-2; PDSS-2) quantify a range of symptoms impacting sleep in only 15 items. However, data from these scales may be problematic

2018 PLoS ONE

178. The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses

correspondence to: Sherene Thomas, PhD, 2510 North Frontage Road, Darien, IL 60561; Tel: (630) 737-9700; Fax: (630) 737-9790; E-mail: sthomas@aasmnet.org The International Classification of Sleep Disorders, Second Edition (ICSD-2) distinguishes 5 subtypes of central sleep apnea syndromes (CSAS) in adults. Review of the literature suggests that there are two basic mechanisms that trigger central respiratory events: (1) post-hyperventilation cen- tral apnea, which may be triggered by a variety of clinical (...) , and nocturnal dialysis. (OPTION) Keywords: Central sleep apnea, clinical guidelines, PAP, oxygen therapy, ASV Citation: Aurora RN; Chowdhuri S; Ramar K; Bista SR; Casey KR; Lamm CI; Kristo DA; Mallea JM; Rowley JA; Zak RS; Tracy SL. The treat- ment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses. SLEEP 2012;35(1):17-40.SLEEP , Vol. 35, No. 1, 2012 18 CSA Practice Parameters—Aurora et al tilatory failure due to neuromuscular disease

2016 American Academy of Sleep Medicine

179. The Prevalence and Characteristics of REM Sleep without Atonia (RSWA) in Patients Taking Antidepressants Full Text available with Trip Pro

The Prevalence and Characteristics of REM Sleep without Atonia (RSWA) in Patients Taking Antidepressants The association of REM sleep without atonia (RSWA) as well as REM sleep behavior disorder (RBD) with the intake of selective serotonin reuptake inhibitors (SSRI) and selective norepinephrine reuptake inhibitors (SNRI) is well established. Our study objective was to determine the prevalence of RSWA and RBD among a group of sleep center patients taking SSRI and SNRI.A retrospective chart (...) review was done at our tertiary sleep center, and 10,746 consecutive records from October 1, 2007, through October 31, 2013, were searched for SSRI and SNRI names using the Sleep Cataloguer Software.The search resulted in 1,444 records, which were then reviewed for keywords of RSWA and RBD. The AASM scoring criteria were used to determine RSWA. Reports of 41 patients with known narcolepsy or α-synucleinopathies were excluded. The remaining records were mined for age, sex, presence of obstructive

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

180. Noradrenaline from Locus Coeruleus Neurons Acts on Pedunculo-Pontine Neurons to Prevent REM Sleep and Induces Its Loss-Associated Effects in Rats Full Text available with Trip Pro

normally REMS does not appear during waking. Also, that LC neurons are the primary source of NA, which in turn causes some, if not many, REMSD-associated symptoms and behavioral changes. The findings are proof-of-principle for the first time and hold potential to be exploited for confirmation toward treating REMS disorder and amelioration of REMS loss-associated symptoms in patients. (...) Noradrenaline from Locus Coeruleus Neurons Acts on Pedunculo-Pontine Neurons to Prevent REM Sleep and Induces Its Loss-Associated Effects in Rats Normally, rapid eye movement sleep (REMS) does not appear during waking or non-REMS. Isolated, independent studies showed that elevated noradrenaline (NA) levels inhibit REMS and induce REMS loss-associated cytomolecular, cytomorphological, psychosomatic changes and associated symptoms. However, the source of NA and its target in the brain for REMS

2016 eNeuro

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