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REM Sleep Behavior Disorder

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141. Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline

with OSA can also have other sleep disorders that may be related to or unrelated to OSA. Comorbid insomnia has been found to be a frequent problem in patients with OSA. It is also possible that undiagnosed OSA may be masquerading as another sleep disorder, such as REM Behavior Disorder. Therefore, when OSA is suspected, a comprehensive sleep evaluation is important to ensure appropriate diagnostic testing is performed to address OSA, as well as other comorbid sleep complaints. The diagnosis of OSA (...) Mayo Clinic, Rochester, MN; 7 American Academy of Sleep Medicine, Darien, IL ABSTRACT Introduction: This guideline establishes clinical practice recommendations for the diagnosis of obstructive sleep apnea (OSA) in adults and is intended for use in conjunction with other American Academy of Sleep Medicine (AASM) guidelines on the evaluation and treatment of sleep-disordered breathing in adults. Methods: The AASM commissioned a task force of experts in sleep medicine. A systematic review

2017 American Academy of Sleep Medicine

142. Diagnostic accuracy of REM sleep behavior disorder screening questionnaires: a meta-analysis

Diagnostic accuracy of REM sleep behavior disorder screening questionnaires: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address

2016 PROSPERO

143. Characteristics of REM Sleep Behavior Disorder in Childhood (PubMed)

Characteristics of REM Sleep Behavior Disorder in Childhood To describe our experience regarding the clinical and polysomnographic features of REM sleep behavior disorder (RBD) in childhood.This was a retrospective chart review of children and adolescents with RBD and REM sleep without atonia. Demographics, and clinical and polysomnographic information were tabulated. Our findings were compared with those in the existing literature.The 15 subjects identified (13 RBD and 2 having REM sleep (...) ), and Moebius Syndrome (1/15). Abnormal MRI scans were seen in 5/8 evaluated subjects. Treatments consisted of clonazepam (10/15), melatonin (2/15), and discontinuation of a tricyclic agent (1/15), with a favorable response in 11 of 13. Two of 15 patients with REM sleep without atonia did not require pharmacotherapy.RBD in children may be associated with neurodevelopmental disabilities, narcolepsy, or medication use. It seems to be modestly responsive to benzodiazepines or melatonin. The etiology

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2012 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

144. Attenuated heart rate response in REM sleep behavior disorder and Parkinson's disease. (PubMed)

Attenuated heart rate response in REM sleep behavior disorder and Parkinson's disease. The objective of this study was to determine whether patients with Parkinson's disease with and without rapid-eye-movement sleep behavior disorder and patients with idiopathic rapid-eye-movement sleep behavior disorder have an attenuated heart rate response to arousals or to leg movements during sleep compared with healthy controls. Fourteen and 16 Parkinson's patients with and without rapid-eye-movement (...) sleep behavior disorder, respectively, 11 idiopathic rapid-eye-movement sleep behavior disorder patients, and 17 control subjects underwent 1 night of polysomnography. The heart rate response associated with arousal or leg movement from all sleep stages was analyzed from 10 heartbeats before the onset of the sleep event to 15 heartbeats following onset of the sleep event. The heart rate reponse to arousals was significantly lower in both parkinsonian groups compared with the control group

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2012 Movement Disorders

145. REM sleep behavior disorder: Motor manifestations and pathophysiology. (PubMed)

REM sleep behavior disorder: Motor manifestations and pathophysiology. Patients with REM sleep behavior disorder (RBD) enact violent dreams during REM sleep in the absence of normal muscle atonia. This disorder is highly frequent in patients with synucleinopathies (60%-100% of patients) and rare in patients with other neurodegenerative disorders. The disorder is detected by interview plus video and sleep monitoring. Abnormal movements expose the patients and bed partners to a high risk (...) of injury and sleep disruption. The disorder is usually alleviated with melatonin and clonazepam. Limb movements are mainly minor, jerky, fast, pseudohallucinatory, and repeated, with a limp wrist during apparently grasping movements, although body jerks and complex violent (fights) and nonviolent culturally acquired behaviors are also observed. Notably, parkinsonism disappears during RBD-associated complex behaviors in patients with Parkinson's disease and with multiple system atrophy, suggesting

2012 Movement Disorders

146. Hiding in plain sight: Risk factors for REM sleep behavior disorder. (PubMed)

Hiding in plain sight: Risk factors for REM sleep behavior disorder. 22744669 2012 10 12 2018 12 01 1526-632X 79 5 2012 Jul 31 Neurology Neurology Hiding in plain sight: risk factors for REM sleep behavior disorder. 402-3 10.1212/WNL.0b013e31825dd3c0 Sullivan Shannon S SS Schenck Carlos H CH Guilleminault Christian C eng Editorial Comment 2012 06 27 United States Neurology 0401060 0028-3878 AIM IM Neurology. 2012 Jul 31;79(5):428-34 22744670 Environment Female Humans Life Style Male REM Sleep (...) Behavior Disorder etiology 2012 6 30 6 0 2012 6 30 6 0 2012 10 13 6 0 ppublish 22744669 WNL.0b013e31825dd3c0 10.1212/WNL.0b013e31825dd3c0

2012 Neurology

147. Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study. (PubMed)

Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study. Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder.Cases were patients with idiopathic REM sleep behavior disorder who were free (...) of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors.A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0% were

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2012 Neurology

148. Validation of the Innsbruck REM sleep behavior disorder inventory. (PubMed)

Validation of the Innsbruck REM sleep behavior disorder inventory. A diagnosis of definite REM sleep behavior disorder requires both a positive history for REM sleep behavior disorder and polysomnographic demonstration of REM sleep without atonia. To improve and facilitate screening for REM sleep behavior disorder, there is a need for simple clinical tools with sufficient sensitivity and specificity for the identification of subjects with probable REM sleep behavior disorder. We developed (...) a short REM sleep behavior disorder screening questionnaire with 7 REM sleep behavior disorder- and 2 non-REM sleep behavior disorder-specific control items and performed a validation study in 70 REM sleep behavior disorder subjects and 140 sleep disorder controls. Response patterns to all 7 REM sleep behavior disorder-specific items differed between REM sleep behavior disorder and non-REM sleep behavior disorder patients (all P < 0.05), whereas the 2 non-REM sleep behavior disorder-specific control

2012 Movement Disorders

149. Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder. (PubMed)

Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder. 23243074 2013 02 25 2012 12 25 1526-632X 80 1 2013 Jan 01 Neurology Neurology Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder. 118-20 10.1212/WNL.0b013e31827b1b2a Flanagan Eoin P EP Department of Neurology, Mayo Clinic, Rochester, MN, USA. Gavrilova Ralitza H RH Boeve Bradley F BF Kumar Neeraj N Jelsing Elena J EJ Silber Michael H MH eng Case Reports Journal (...) Article 2012 12 12 United States Neurology 0401060 0028-3878 Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant AIM IM Brain Waves physiology Humans Magnetic Resonance Imaging methods psychology Male Middle Aged Pelizaeus-Merzbacher Disease complications diagnosis physiopathology Polysomnography methods psychology REM Sleep Behavior Disorder complications diagnosis physiopathology 2012 12 18 6 0 2012 12 18 6 0 2013 2 26 6 0 ppublish 23243074 WNL.0b013e31827b1b2a 10.1212/WNL

2012 Neurology

150. Understanding the Natural History of REM Sleep Behavior Disorder

Understanding the Natural History of REM Sleep Behavior Disorder Understanding the Natural History of REM Sleep Behavior Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Understanding the Natural (...) History of REM Sleep Behavior Disorder The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01674998 Recruitment Status : Unknown Verified August 2012 by J. William Langston, The Parkinson's Institute. Recruitment status was: Recruiting First Posted : August 29, 2012 Last Update Posted : August 29, 2012

2012 Clinical Trials

151. REM Sleep Behavior Disorder

REM Sleep Behavior Disorder REM Sleep Behavior Disorder Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 REM Sleep Behavior Disorder (...) REM Sleep Behavior Disorder Aka: REM Sleep Behavior Disorder From Related Chapters II. Epidemiology More common in men than women III. Signs Increased motor tone during sleep Patient acts out dreams during Flails limbs Vocalizes May fall out of bed IV. Complications Risk of injury to patient or bed partner V. Associated Conditions (and related s) Spinocerebellar Severe s VI. Diagnosis VII. Management Treat underlying causes (e.g. , , discontinue causative medications) Remove fragile or dangerous

2015 FP Notebook

152. Unimpaired postprandial pancreatic polypeptide secretion in Parkinson's disease and REM sleep behavior disorder. (PubMed)

Unimpaired postprandial pancreatic polypeptide secretion in Parkinson's disease and REM sleep behavior disorder. Pancreatic polypeptide is released immediately after food ingestion. The release is operated by vagal-abdominal projections and has therefore been suggested as a test for vagal nerve integrity. Pathoanatomical and clinical studies indicate vagal dysfunction in early Parkinson's disease (PD).We assessed the postprandial secretion of pancreatic polypeptide and motilin in healthy (...) controls (n = 18) and patients with idiopathic rapid-eye-movement sleep behavior disorder (iRBD, n = 10), a potential premotor stage of PD, as well as in drug-naive (n = 19) and treated (n = 19) PD patients.The postprandial pancreatic polypeptide secretion showed a physiological pattern in all groups and even an enhanced response in drug-naive PD and iRBD. Motilin concentrations correlated with pancreatic polypeptide concentrations.Postprandial pancreatic polypeptide secretion is not a suitable test

2012 Movement Disorders

153. Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder. (PubMed)

Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder. Patients with idiopathic REM sleep behavior disorder (IRBD) are at risk for developing Parkinson disease (PD) and dementia with Lewy bodies (DLB). We aimed to identify functional brain imaging patterns predicting the emergence of PD and DLB in patients with IRBD, using SPECT with (99m)Tc-ethylene cysteinate dimer (ECD).Twenty patients with IRBD were scanned at baseline during wakefulness using (99m)Tc-ECD (...) in this process.Of the 20 patients with IRBD recruited for this study, 10 converted to PD or DLB during the follow-up. rCBF at baseline was increased in the hippocampus of patients who would later convert compared with those who would not (p < 0.05 corrected). Hippocampal perfusion was correlated with motor and color vision scores across all IRBD patients.(99m)Tc-ECD SPECT identifies patients with IRBD at risk for conversion to other neurodegenerative disorders such as PD or DLB; disease progression in IRBD

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2012 Neurology

154. Sleep Behavior and Hip/Knee Prosthesis

Sleep Behavior and Hip/Knee Prosthesis Sleep Behavior and Hip/Knee Prosthesis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Sleep Behavior and Hip/Knee Prosthesis (Sleep) The safety and scientific (...) Ortopedico Galeazzi Study Details Study Description Go to Brief Summary: The consequences of chronically insufficient sleep are both behavioral and medical. . Patients who undergo total knee or hip arthroplasty commonly complain of sleep fragmentation after hospitalization The aim of the present study is to evaluate the changes in objective and subjective sleep quality and perceived pain, untill the 10th hospitalization day, in patients who underwent total knee or hip arthroplasty. Condition or disease

2018 Clinical Trials

155. Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease (PubMed)

Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease Over 50% of persons with idiopathic REM sleep behavior disorder (RBD) will develop Parkinson disease (PD) or dementia. At present, there is no way to predict who will develop disease. Since polysomnography is performed in all patients with idiopathic RBD at diagnosis, there is an opportunity to analyze if baseline sleep variables predict eventual neurodegenerative disease.In a longitudinally studied (...) 41.0 +/- 6.0%, p = 0.002), and not in those who developed dementia (54.3 +/- 10.3, p = 0.28). There was no difference in phasic submental REM EMG activity between groups.In patients with REM sleep behavior disorder initially free of neurodegenerative disease, the severity of REM atonia loss on baseline polysomnogram predicts the development of Parkinson disease.

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2010 EvidenceUpdates

156. Long-Term Follow-up Investigation of Isolated Rapid Eye Movement Sleep Without Atonia Without Rapid Eye Movement Sleep Behavior Disorder: A Pilot Study (PubMed)

Long-Term Follow-up Investigation of Isolated Rapid Eye Movement Sleep Without Atonia Without Rapid Eye Movement Sleep Behavior Disorder: A Pilot Study Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a harbinger of synuclein-mediated neurodegenerative diseases. It is unknown if this also applies to isolated REM sleep without atonia (RWA). We performed a long-term follow-up investigation of subjects with isolated RWA.Participants were recruited from 50 subjects with isolated (...) RWA who were identified at the sleep laboratory of the Department of Neurology at the Medical University of Innsbruck between 2003 and 2005. Eligible subjects underwent follow-up clinical examination, polysomnography, and assessment of neurodegenerative biomarkers (cognitive impairment, finger speed deficit, impaired color vision, olfactory dysfunction, orthostatic hypotension, and substantia nigra hyperechogenicity).After a mean of 8.6 ± 0.9 y, 1 of 14 participating subjects (7.3%) progressed

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2015 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

157. Sleep disorders and Parkinson disease; lessons from genetics. (PubMed)

during its prodromal phase. However, with the exception of REM sleep behavior disorder, it is unclear whether they are part of the early pathological process of Parkinson disease, or if they develop as Parkinson disease advances because of treatments and neurodegeneration progression. The advancements in genetic studies in the past two decades have generated a wealth of information, and recent genetic studies offer new insight on the association of sleep-related disorders with Parkinson disease. More (...) Sleep disorders and Parkinson disease; lessons from genetics. Parkinson disease is a common, age-related neurodegenerative disorder, projected to afflict millions of individuals in the near future. Understanding its etiology and identifying clinical, genetic or biological markers for Parkinson disease onset and progression is therefore of major importance. Various sleep-related disorders are the most common group of non-motor symptoms in advanced Parkinson disease, but they can also occur

2018 Sleep medicine reviews

158. A Review of Scales to Evaluate Sleep Disturbances in Movement Disorders (PubMed)

A Review of Scales to Evaluate Sleep Disturbances in Movement Disorders Patients with movement disorders have a high prevalence of sleep disturbances that can be classified as (1) nocturnal sleep symptoms, such as insomnia, nocturia, restless legs syndrome (RLS), periodic limb movements (PLM), obstructive sleep apnea (OSA), and REM sleep behavior disorder; and (2) diurnal problems that include excessive daytime sleepiness (EDS) and sleep attacks. The objective of this review is to provide (...) a practical overview of the most relevant scales that assess these disturbances to guide the choice of the most useful instrument/s depending on the line of research or clinical focus. For each scale, the reader will find a brief description of practicalities and psychometric properties, use in movement disorder cohorts and analyzed strengths and limitations. To assess insomnia, the Pittsburgh Sleep Quality Index, a generic scale, and three disease-specific scales: the Parkinson Disease Sleep Scale (PDSS

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2018 Frontiers in neurology

159. Cardiac Sympathetic Activity differentiates Idiopathic and Symptomatic Rapid Eye Movement Sleep Behaviour Disorder (PubMed)

Cardiac Sympathetic Activity differentiates Idiopathic and Symptomatic Rapid Eye Movement Sleep Behaviour Disorder The pathophysiology of rapid eye movement sleep behavior disorder (RBD) associated with narcolepsy type 1 (NT1) is still poorly understood, potentially distinct from idiopathic RBD (iRBD), but may share affected common pathways. We investigated whether MIBG cardiac uptake differs between iRBD and NT1 comorbid with RBD. Thirty-four patients with NT1-RBD and 15 patients with iRBD (...) underwent MIBG cardiac scintigraphy. MIBG uptake was measured by calculating the early and delayed heart to mediastinum (H/M) ratios. A delayed H/M ratio lower than 1.46 was considered abnormal based on a population of 78 subjects without neurological or cardiac diseases. Patients with iRBD were older, had an older RBD onset age and higher REM sleep phasic and tonic muscular activities than NT1-RBD. Lower delayed and early H/M ratios were associated with iRBD, but not with NT1-RBD, in crude and adjusted

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2018 Scientific reports

160. Sleep-related Eating Disorder in a Patient with Parkinson's Disease (PubMed)

Sleep-related Eating Disorder in a Patient with Parkinson's Disease Sleep disorders constitute a major aspect of the non-motor symptoms of Parkinson's disease (PD). Rapid eye movement (REM) behavior disorders are the most frequently experienced parasomnias in patients with PD. Non-REM sleep disorders like confusional arousals, sleep terrors, sleepwalking, and sleep-related eating disorder (SRED) are also associated with PD. Parasomnias can affect the quality of life of the patients as well (...) as the night time sleep of their bed partners. Hence, it is important for physicians to recognize the occurrence of parasomnias in PD. We report an unusual case of PD with SRED along with obstructive sleep apnea (OSA) and REM behavior disorder. To our knowledge, only two cases have been reported in the literature highlighting the association of SRED with PD. We also explain the different night-time eating disorders like nocturnal eating syndrome and binge eating syndrome, which can be seen in PD

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2018 Cureus

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