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REM Sleep Behavior Disorder

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141. REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease. Full Text available with Trip Pro

REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease. Concomitant REM sleep behaviour disorder (RBD) is commonly observed in patients with Parkinson's disease (PD). Although the brainstem structures responsible for the symptoms of RBD correspond to the premotor stages of PD, the association of RBD with motor and non-motor features in early PD remains unclear.The study evaluated 475 patients with PD within 3.5 years (...) of diagnosis for the presence of probable RBD (pRBD) using the REM Sleep Behaviour Disorder Screening Questionnaire (RBDSQ). A neurologist and a trained research nurse carried out evaluation of each participant blinded to the results of the RBDSQ. Standardised rating scales for motor and non-motor features of PD, as well as health-related quality of life measures, were assessed. Multiple linear and logistic regression analyses were used to determine the relationship between pRBD and a variety of outcomes

2013 Neurosurgery and Psychiatry

142. Risk factors associated to REM Behaviour Sleep Disorder per se and in relation to Parkinson's Disease: a systematic review

Risk factors associated to REM Behaviour Sleep Disorder per se and in relation to Parkinson's Disease: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence (...) is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome, the choice of effect measure, how subgroup variables are stratified etc. In order to assess the robustness of the findings of the meta-analysis, the analyses

2016 PROSPERO

143. REM Sleep Behavior and Motor Findings in Parkinson's Disease: A Cross-sectional Analysis Full Text available with Trip Pro

REM Sleep Behavior and Motor Findings in Parkinson's Disease: A Cross-sectional Analysis Parkinson's disease (PD) represents a major public health challenge that will only grow in our aging population. Understanding the connection between PD and associated prodromal conditions, such as rapid eye movement sleep behavioral disorder (RBD), is critical to identifying prevention strategies. However, the relationship between RBD and severity of motor findings in early PD is unknown. This study aims (...) to examine this relationship.The study population consisted of 418 PD patients who completed the Movement Disorders Society-United Parkinson's Disease Rating Scale (MDS-UPDRS) and rapid eye movement sleep (REM) disorder questionnaires at the baseline visit of the Michael J. Fox's Parkinson's Progression Markers Initiative (PPMI). Cross-sectional analysis was carried out to assess the association between REM Sleep Behavior Screening Questionnaire score and MDS UPDRS-3 (motor) score categories. Correlation

2014 Tremor and Other Hyperkinetic Movements

144. Five-year follow-up of substantia nigra echogenicity in idiopathic REM sleep behavior disorder. (Abstract)

Five-year follow-up of substantia nigra echogenicity in idiopathic REM sleep behavior disorder. Hyperechogenicity of the substantia nigra visualized by transcranial sonography occurs in most Parkinson's disease (PD) patients. Idiopathic rapid eye movement (REM) sleep behavior disorder (IRBD) subjects eventually develop PD and other synucleinopathies. This study was undertaken to evaluate whether in IRBD, transcranial sonography identifies subjects who convert to PD and other synucleinopathies (...)  = 0.125). Transcranial sonography of the substantia nigra alone is not a useful tool to identify IRBD subjects at risk for the development of PD or a synucleinopathy after 5 years of follow-up. In IRBD, transcranial sonography cannot be used to monitor the degenerative process in the substantia nigra, because echogenicity size remains stable over time.© 2014 International Parkinson and Movement Disorder Society.

2014 Movement Disorders

145. Abnormal metabolic network activity in REM sleep behavior disorder. Full Text available with Trip Pro

Abnormal metabolic network activity in REM sleep behavior disorder. To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion.For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy (...) control values.PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r(2) = 0.64, p < 0.0001).Latent network abnormalities

2014 Neurology

146. Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism

: Ministry of Food and Drug Safety, Korea Information provided by (Responsible Party): BS Jeon, Seoul National University Hospital Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether clonazepam is effective and safe in the treatment of rapid eye movement behavior disorder (RBD) of patients with Parkinson's disease (PD). Condition or disease Intervention/treatment Phase REM Sleep Behavior Disorder Drug: Clonazepam Drug: Placebo Phase 2 Detailed (...) Last Verified: April 2016 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: Undecided Keywords provided by BS Jeon, Seoul National University Hospital: REM Sleep Behavior Disorder Parkinson Disease Placebos Randomized Controlled Trial Double-Blind Method Clinical Trial Additional relevant MeSH terms: Layout table for MeSH terms Disease Mental Disorders Parkinsonian Disorders REM Sleep Behavior Disorder Pathologic Processes Basal Ganglia Diseases Brain Diseases Central Nervous

2014 Clinical Trials

147. Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke. Full Text available with Trip Pro

Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke. Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disturbance in which patients enact their dreams while in REM sleep. The behavior is typically violent in association with violent dream content, so serious harm can be done to the patient or the bed partner. The prevalence of RBD is well-known in Parkinson's disease, Lewy body dementia, and multiple systems atrophy. However, its prevalence (...) the severity of each stroke using the National Institute of Health Stroke Scale (NIHSS). One hundred and nineteen of the 775 patients meeting study entry criteria formed the study sample. All eligible participants were invited to attend a research clinic 3 months after the onset of the index stroke. In the attendance, a research assistant administered the MMSE and the 13-item RBD questionnaire (RBDQ).Among 119 stroke patients, 10.9% were exhibited RBD, defined as an REM sleep behavior disorder

2014 BMC Neurology

148. Overview of Sleep and Circadian Rhythm Disorders in Parkinson Disease. (Abstract)

specific features of the most common sleep disorders in PD, including insomnia, excessive daytime sleepiness, sleep-disordered breathing, restless legs syndrome, circadian rhythm disorders and REM sleep behavior disorders.Copyright © 2019 Elsevier Inc. All rights reserved. (...) Overview of Sleep and Circadian Rhythm Disorders in Parkinson Disease. Sleep disorders are common among PD patients and affect quality of life. They are often under-recognized and under-treated. Mechanisms of sleep disorders in PD remain relatively poorly understood. Improved awareness of common sleep problems in PD. Tailored treatment and evidence for efficacy are lacking. The purpose of this review is to provide an overview and update on the most common sleep disorders in PD. We review

2020 Clinics in Geriatric Medicine

149. Does Postural Rigidity Decrease during REM Sleep without Atonia in Parkinson Disease? Full Text available with Trip Pro

Does Postural Rigidity Decrease during REM Sleep without Atonia in Parkinson Disease? Rigidity is a muscle hypertonia typical of Parkinson disease (PD), whereas rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by abnormally increased muscle tone during REM sleep (REM sleep without atonia) and enacting dream behaviors. Because movements are not bradykinetic during RBD in patients with PD, we investigated whether the background, wake postural rigidity is attenuated during (...) REM sleep without atonia, in absence of movement.The amplitude of levator menti (postural muscle) electromyographic activity during relaxed evening wakefulness (considered as reference) and sleep (N2, N3, atonic REM sleep, and quiet REM sleep without atonia) was measured in 20 patients with PD (with and without RBD), 10 patients with idiopathic RBD patients and 10 healthy subjects.The chin tone amplitude progressively decreased from wake to N2, N3, and atonic REM sleep in the four groups

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

150. Conditioning of amitriptyline-induced REM sleep suppression in healthy participants: A randomized controlled trial. (Abstract)

Conditioning of amitriptyline-induced REM sleep suppression in healthy participants: A randomized controlled trial. Clinical trials in sleep disorders report substantial improvement in symptoms in their placebo groups. Behavioral conditioning is one of the underlying mechanisms of the placebo response. However, we do not know whether, and if so, the extent to which sleep architecture is influenced by behavioral conditioning, similarly to other physiological responses (i.e., those in the immune (...) system). We therefore applied a conditioning paradigm to 39 healthy adults pairing a novel-tasting drink (conditioned stimulus, CS) with the REM sleep suppressing tricyclic antidepressant amitriptyline as unconditioned stimulus during the acquisition phase. Subsequent sole presentation of the CS (together with a placebo pill) in an evocation night led to significantly more REM sleep in the amitriptyline group. Instead of the expected REM sleep suppression in the evocation night, we observed more REM

2016 Psychophysiology Controlled trial quality: uncertain

151. REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. (Abstract)

REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. Rapid eye movement (REM) sleep behavior disorder (RBD) is commonly associated with Lewy body disease, narcolepsy, or depression. In contrast, the relationship between REM sleep without atonia (RWA), which is a hallmark of RBD on polysomnography, and clinical characteristics remains unclear. The purpose of this study is to investigate the clinical features of psychiatric patients (...) exhibiting RWA and its relevance to Lewy body disease.Of 55 consecutive patients who underwent polysomnography at the psychiatric ward, 25 patients with sleep apnea syndrome were excluded, and 12 patients exhibiting RWA were identified. The clinical profiles were compared between the groups with and without RWA.The mean age and the frequency of neurocognitive disorders were significantly higher in 12 patients with RWA than in 18 without. Only five of the 12 patients exhibiting RWA had episodes of dream

2016 International Journal of Geriatric Psychiatry

152. Alternatives to Clonazepam in REM Behavior Disorder Treatment Full Text available with Trip Pro

Alternatives to Clonazepam in REM Behavior Disorder Treatment 27397658 2018 08 17 2018 12 02 1550-9397 12 8 2016 08 15 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine J Clin Sleep Med Alternatives to Clonazepam in REM Behavior Disorder Treatment. 1193 10.5664/jcsm.6068 Escribá Jesús J Sleep Unit, Neurophysiology Department, Lluís Alcanyís Hospital, Xátiva, Valencia, Spain. Hoyo Blanca B Sleep Unit, Neurophysiology Department, Lluís (...) Alcanyís Hospital, Xátiva, Valencia, Spain. eng Letter Comment 2016 08 15 United States J Clin Sleep Med 101231977 1550-9389 5PE9FDE8GB Clonazepam JL5DK93RCL Melatonin IM J Clin Sleep Med. 2016 May 15;12(5):689-93 26857053 J Clin Sleep Med. 2016 Aug 15;12(8):1195-6 27448419 Clonazepam Humans Melatonin Polysomnography REM Sleep Behavior Disorder 2016 05 26 2016 06 02 2016 7 12 6 0 2016 7 12 6 0 2018 8 18 6 0 epublish 27397658 jc-00150-16 10.5664/jcsm.6068 PMC4957199 Sleep Med. 2013 Mar;14(3):237-42

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

153. REM sleep behavior disorder in Parkinson's disease: A case from India confirmed with polysomnographic data Full Text available with Trip Pro

REM sleep behavior disorder in Parkinson's disease: A case from India confirmed with polysomnographic data Rapid eye movement (REM) sleep behavior disorder is a condition characterized by dream enactment. This condition may accompany neurodegenerative disorders. However, only a few reports from India are available, that too, without any polysomnographic evidence. We are reporting a case of REM sleep behavior disorder with polysomnographic evidence.

2013 Journal of neurosciences in rural practice

154. Questionnaire-based diagnosis of REM sleep behavior disorder in Parkinson's disease. Full Text available with Trip Pro

Questionnaire-based diagnosis of REM sleep behavior disorder in Parkinson's disease. Rapid eye movement (REM) sleep behavior disorder (RBD) is present in around 40% of Parkinson's disease (PD) patients. Definitive diagnosis requires a polysomnogram, but that is costly, time intensive, and not practical for large-scale studies. Therefore, we assessed using a questionnaire-based diagnostic approach.The patient-administered RBD questionnaire and bed-partner-administered question 1 of the Mayo (...) questionnaire were prospectively validated.Seventy-five PD patients (51 male, 68 Hoehn and Yahr stages I and II) participated. Forty-eight had a clinical history of RBD. Sensitivity was 100% (95% CI, 86.3%-100%) when a combination of both questionnaires was compared with the gold standard of polysomnogram-confirmed RBD. Among those who achieved REM sleep (n=65), specificity was highest for the patient questionnaire used alone, at 82.4% (95% CI, 64.8%-92.6%).A combination of patient and bed-partner

2013 Movement Disorders

155. REM Sleep Behavior Disorder (Treatment)

, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology . 1996 Feb. 46(2):388-93. . Tachibana N, Oka Y. Longitudinal change in REM sleep components in a patient with multiple system atrophy associated with REM sleep behavior disorder: paradoxical improvement of nocturnal behaviors in a progressive neurodegenerative disease. Sleep Med . 2004 Mar. 5(2):155-8. . Nihei Y (...) sleep regulation: REM sleep behaviour disorder: an update on a series of 96 patients and a review of the world literature. J Sleep Res . 1993 Dec. 2(4):224-231. . Gagnon JF, Postuma RB, Montplaisir J. Update on the pharmacology of REM sleep behavior disorder. Neurology . 2006 Sep 12. 67(5):742-7. . Comella CL, Nardine TM, Diederich NJ, Stebbins GT. Sleep-related violence, injury, and REM sleep behavior disorder in Parkinson's disease. Neurology . 1998 Aug. 51(2):526-9. . Takeuchi N, Uchimura N

2014 eMedicine.com

156. REM Sleep Behavior Disorder (Overview)

sleep behaviour disorder. Neurology . 1996 Feb. 46(2):388-93. . Tachibana N, Oka Y. Longitudinal change in REM sleep components in a patient with multiple system atrophy associated with REM sleep behavior disorder: paradoxical improvement of nocturnal behaviors in a progressive neurodegenerative disease. Sleep Med . 2004 Mar. 5(2):155-8. . Nihei Y, Takahashi K, Koto A, Mihara B, Morita Y, Isozumi K, et al. REM sleep behavior disorder in Japanese patients with Parkinson's disease: a multicenter study (...) , Noachtar S, et al. Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson's disease and controls. Brain . 2000 Jun. 123 ( Pt 6):1155-60. . Fantini ML, Gagnon JF, Petit D, et al. Slowing of electroencephalogram in rapid eye movement sleep behavior disorder. Ann Neurol . 2003 Jun. 53(6):774-80. . Ferini-Strambi L, Di Gioia MR, Castronovo V, Oldani A, Zucconi M, Cappa SF. Neuropsychological assessment in idiopathic REM sleep behavior

2014 eMedicine.com

157. REM Sleep Behavior Disorder (Follow-up)

, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology . 1996 Feb. 46(2):388-93. . Tachibana N, Oka Y. Longitudinal change in REM sleep components in a patient with multiple system atrophy associated with REM sleep behavior disorder: paradoxical improvement of nocturnal behaviors in a progressive neurodegenerative disease. Sleep Med . 2004 Mar. 5(2):155-8. . Nihei Y (...) sleep regulation: REM sleep behaviour disorder: an update on a series of 96 patients and a review of the world literature. J Sleep Res . 1993 Dec. 2(4):224-231. . Gagnon JF, Postuma RB, Montplaisir J. Update on the pharmacology of REM sleep behavior disorder. Neurology . 2006 Sep 12. 67(5):742-7. . Comella CL, Nardine TM, Diederich NJ, Stebbins GT. Sleep-related violence, injury, and REM sleep behavior disorder in Parkinson's disease. Neurology . 1998 Aug. 51(2):526-9. . Takeuchi N, Uchimura N

2014 eMedicine.com

158. REM Sleep Behavior Disorder (Diagnosis)

sleep behaviour disorder. Neurology . 1996 Feb. 46(2):388-93. . Tachibana N, Oka Y. Longitudinal change in REM sleep components in a patient with multiple system atrophy associated with REM sleep behavior disorder: paradoxical improvement of nocturnal behaviors in a progressive neurodegenerative disease. Sleep Med . 2004 Mar. 5(2):155-8. . Nihei Y, Takahashi K, Koto A, Mihara B, Morita Y, Isozumi K, et al. REM sleep behavior disorder in Japanese patients with Parkinson's disease: a multicenter study (...) , Noachtar S, et al. Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson's disease and controls. Brain . 2000 Jun. 123 ( Pt 6):1155-60. . Fantini ML, Gagnon JF, Petit D, et al. Slowing of electroencephalogram in rapid eye movement sleep behavior disorder. Ann Neurol . 2003 Jun. 53(6):774-80. . Ferini-Strambi L, Di Gioia MR, Castronovo V, Oldani A, Zucconi M, Cappa SF. Neuropsychological assessment in idiopathic REM sleep behavior

2014 eMedicine.com

159. Motor Control During Rapid Eye Movement (REM) Sleep Behaviour Disorder

Potentials to Investigate Motor Control During REM Sleep Behaviour Disorder (TCSP) Secondary to Idiopathic Parkinsons Disease (PD) Study Start Date : June 2013 Actual Primary Completion Date : June 2014 Actual Study Completion Date : July 2014 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Synchronised video-polysomnography Other: Synchronised video-polysomnography We will record (...) : Layout table for MeSH terms Parkinson Disease Mental Disorders REM Sleep Behavior Disorder Parkinsonian Disorders Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Nervous System Diseases Movement Disorders Neurodegenerative Diseases REM Sleep Parasomnias Parasomnias Sleep Wake Disorders

2013 Clinical Trials

160. α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model. Full Text available with Trip Pro

of human α-synuclein very similar to that of endogenous mouse α-synuclein. They expressed truncated, oligomeric and proteinase K-resistant phosphorylated forms of α-synuclein in the regions that are specifically affected in Parkinson's disease and/or dementia with Lewy bodies, including the olfactory bulb, cerebral cortex, striatum and substantia nigra. Surprisingly, these mice exhibited rapid eye movement (REM) sleep without atonia, which is a key feature of REM sleep behaviour disorder, at as early (...) α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model. Parkinson's disease is one of the most common movement disorders and is characterized by dopaminergic cell loss and the accumulation of pathological α-synuclein, but its precise pathogenetic mechanisms remain elusive. To develop disease-modifying therapies for Parkinson's disease, an animal model that recapitulates the pathology and symptoms of the disease, especially in the prodromal

2020 Brain

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