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REM Sleep Behavior Disorder

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141. REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. (Abstract)

REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. Rapid eye movement (REM) sleep behavior disorder (RBD) is commonly associated with Lewy body disease, narcolepsy, or depression. In contrast, the relationship between REM sleep without atonia (RWA), which is a hallmark of RBD on polysomnography, and clinical characteristics remains unclear. The purpose of this study is to investigate the clinical features of psychiatric patients (...) exhibiting RWA and its relevance to Lewy body disease.Of 55 consecutive patients who underwent polysomnography at the psychiatric ward, 25 patients with sleep apnea syndrome were excluded, and 12 patients exhibiting RWA were identified. The clinical profiles were compared between the groups with and without RWA.The mean age and the frequency of neurocognitive disorders were significantly higher in 12 patients with RWA than in 18 without. Only five of the 12 patients exhibiting RWA had episodes of dream

2016 International Journal of Geriatric Psychiatry

142. Does Postural Rigidity Decrease during REM Sleep without Atonia in Parkinson Disease? Full Text available with Trip Pro

Does Postural Rigidity Decrease during REM Sleep without Atonia in Parkinson Disease? Rigidity is a muscle hypertonia typical of Parkinson disease (PD), whereas rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by abnormally increased muscle tone during REM sleep (REM sleep without atonia) and enacting dream behaviors. Because movements are not bradykinetic during RBD in patients with PD, we investigated whether the background, wake postural rigidity is attenuated during (...) REM sleep without atonia, in absence of movement.The amplitude of levator menti (postural muscle) electromyographic activity during relaxed evening wakefulness (considered as reference) and sleep (N2, N3, atonic REM sleep, and quiet REM sleep without atonia) was measured in 20 patients with PD (with and without RBD), 10 patients with idiopathic RBD patients and 10 healthy subjects.The chin tone amplitude progressively decreased from wake to N2, N3, and atonic REM sleep in the four groups

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

143. Conditioning of amitriptyline-induced REM sleep suppression in healthy participants: A randomized controlled trial. (Abstract)

Conditioning of amitriptyline-induced REM sleep suppression in healthy participants: A randomized controlled trial. Clinical trials in sleep disorders report substantial improvement in symptoms in their placebo groups. Behavioral conditioning is one of the underlying mechanisms of the placebo response. However, we do not know whether, and if so, the extent to which sleep architecture is influenced by behavioral conditioning, similarly to other physiological responses (i.e., those in the immune (...) system). We therefore applied a conditioning paradigm to 39 healthy adults pairing a novel-tasting drink (conditioned stimulus, CS) with the REM sleep suppressing tricyclic antidepressant amitriptyline as unconditioned stimulus during the acquisition phase. Subsequent sole presentation of the CS (together with a placebo pill) in an evocation night led to significantly more REM sleep in the amitriptyline group. Instead of the expected REM sleep suppression in the evocation night, we observed more REM

2016 Psychophysiology Controlled trial quality: uncertain

144. Alternatives to Clonazepam in REM Behavior Disorder Treatment Full Text available with Trip Pro

Alternatives to Clonazepam in REM Behavior Disorder Treatment 27397658 2018 08 17 2018 12 02 1550-9397 12 8 2016 08 15 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine J Clin Sleep Med Alternatives to Clonazepam in REM Behavior Disorder Treatment. 1193 10.5664/jcsm.6068 Escribá Jesús J Sleep Unit, Neurophysiology Department, Lluís Alcanyís Hospital, Xátiva, Valencia, Spain. Hoyo Blanca B Sleep Unit, Neurophysiology Department, Lluís (...) Alcanyís Hospital, Xátiva, Valencia, Spain. eng Letter Comment 2016 08 15 United States J Clin Sleep Med 101231977 1550-9389 5PE9FDE8GB Clonazepam JL5DK93RCL Melatonin IM J Clin Sleep Med. 2016 May 15;12(5):689-93 26857053 J Clin Sleep Med. 2016 Aug 15;12(8):1195-6 27448419 Clonazepam Humans Melatonin Polysomnography REM Sleep Behavior Disorder 2016 05 26 2016 06 02 2016 7 12 6 0 2016 7 12 6 0 2018 8 18 6 0 epublish 27397658 jc-00150-16 10.5664/jcsm.6068 PMC4957199 Sleep Med. 2013 Mar;14(3):237-42

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

145. REM sleep behavior disorder in Parkinson's disease: A case from India confirmed with polysomnographic data Full Text available with Trip Pro

REM sleep behavior disorder in Parkinson's disease: A case from India confirmed with polysomnographic data Rapid eye movement (REM) sleep behavior disorder is a condition characterized by dream enactment. This condition may accompany neurodegenerative disorders. However, only a few reports from India are available, that too, without any polysomnographic evidence. We are reporting a case of REM sleep behavior disorder with polysomnographic evidence.

2013 Journal of neurosciences in rural practice

146. Questionnaire-based diagnosis of REM sleep behavior disorder in Parkinson's disease. Full Text available with Trip Pro

Questionnaire-based diagnosis of REM sleep behavior disorder in Parkinson's disease. Rapid eye movement (REM) sleep behavior disorder (RBD) is present in around 40% of Parkinson's disease (PD) patients. Definitive diagnosis requires a polysomnogram, but that is costly, time intensive, and not practical for large-scale studies. Therefore, we assessed using a questionnaire-based diagnostic approach.The patient-administered RBD questionnaire and bed-partner-administered question 1 of the Mayo (...) questionnaire were prospectively validated.Seventy-five PD patients (51 male, 68 Hoehn and Yahr stages I and II) participated. Forty-eight had a clinical history of RBD. Sensitivity was 100% (95% CI, 86.3%-100%) when a combination of both questionnaires was compared with the gold standard of polysomnogram-confirmed RBD. Among those who achieved REM sleep (n=65), specificity was highest for the patient questionnaire used alone, at 82.4% (95% CI, 64.8%-92.6%).A combination of patient and bed-partner

2013 Movement Disorders

147. REM Sleep Behavior Disorder (Diagnosis)

sleep behaviour disorder. Neurology . 1996 Feb. 46(2):388-93. . Tachibana N, Oka Y. Longitudinal change in REM sleep components in a patient with multiple system atrophy associated with REM sleep behavior disorder: paradoxical improvement of nocturnal behaviors in a progressive neurodegenerative disease. Sleep Med . 2004 Mar. 5(2):155-8. . Nihei Y, Takahashi K, Koto A, Mihara B, Morita Y, Isozumi K, et al. REM sleep behavior disorder in Japanese patients with Parkinson's disease: a multicenter study (...) , Noachtar S, et al. Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson's disease and controls. Brain . 2000 Jun. 123 ( Pt 6):1155-60. . Fantini ML, Gagnon JF, Petit D, et al. Slowing of electroencephalogram in rapid eye movement sleep behavior disorder. Ann Neurol . 2003 Jun. 53(6):774-80. . Ferini-Strambi L, Di Gioia MR, Castronovo V, Oldani A, Zucconi M, Cappa SF. Neuropsychological assessment in idiopathic REM sleep behavior

2014 eMedicine.com

148. REM Sleep Behavior Disorder (Follow-up)

, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology . 1996 Feb. 46(2):388-93. . Tachibana N, Oka Y. Longitudinal change in REM sleep components in a patient with multiple system atrophy associated with REM sleep behavior disorder: paradoxical improvement of nocturnal behaviors in a progressive neurodegenerative disease. Sleep Med . 2004 Mar. 5(2):155-8. . Nihei Y (...) sleep regulation: REM sleep behaviour disorder: an update on a series of 96 patients and a review of the world literature. J Sleep Res . 1993 Dec. 2(4):224-231. . Gagnon JF, Postuma RB, Montplaisir J. Update on the pharmacology of REM sleep behavior disorder. Neurology . 2006 Sep 12. 67(5):742-7. . Comella CL, Nardine TM, Diederich NJ, Stebbins GT. Sleep-related violence, injury, and REM sleep behavior disorder in Parkinson's disease. Neurology . 1998 Aug. 51(2):526-9. . Takeuchi N, Uchimura N

2014 eMedicine.com

149. REM Sleep Behavior Disorder (Treatment)

, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology . 1996 Feb. 46(2):388-93. . Tachibana N, Oka Y. Longitudinal change in REM sleep components in a patient with multiple system atrophy associated with REM sleep behavior disorder: paradoxical improvement of nocturnal behaviors in a progressive neurodegenerative disease. Sleep Med . 2004 Mar. 5(2):155-8. . Nihei Y (...) sleep regulation: REM sleep behaviour disorder: an update on a series of 96 patients and a review of the world literature. J Sleep Res . 1993 Dec. 2(4):224-231. . Gagnon JF, Postuma RB, Montplaisir J. Update on the pharmacology of REM sleep behavior disorder. Neurology . 2006 Sep 12. 67(5):742-7. . Comella CL, Nardine TM, Diederich NJ, Stebbins GT. Sleep-related violence, injury, and REM sleep behavior disorder in Parkinson's disease. Neurology . 1998 Aug. 51(2):526-9. . Takeuchi N, Uchimura N

2014 eMedicine.com

150. REM Sleep Behavior Disorder (Overview)

sleep behaviour disorder. Neurology . 1996 Feb. 46(2):388-93. . Tachibana N, Oka Y. Longitudinal change in REM sleep components in a patient with multiple system atrophy associated with REM sleep behavior disorder: paradoxical improvement of nocturnal behaviors in a progressive neurodegenerative disease. Sleep Med . 2004 Mar. 5(2):155-8. . Nihei Y, Takahashi K, Koto A, Mihara B, Morita Y, Isozumi K, et al. REM sleep behavior disorder in Japanese patients with Parkinson's disease: a multicenter study (...) , Noachtar S, et al. Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson's disease and controls. Brain . 2000 Jun. 123 ( Pt 6):1155-60. . Fantini ML, Gagnon JF, Petit D, et al. Slowing of electroencephalogram in rapid eye movement sleep behavior disorder. Ann Neurol . 2003 Jun. 53(6):774-80. . Ferini-Strambi L, Di Gioia MR, Castronovo V, Oldani A, Zucconi M, Cappa SF. Neuropsychological assessment in idiopathic REM sleep behavior

2014 eMedicine.com

151. Motor Control During Rapid Eye Movement (REM) Sleep Behaviour Disorder

Potentials to Investigate Motor Control During REM Sleep Behaviour Disorder (TCSP) Secondary to Idiopathic Parkinsons Disease (PD) Study Start Date : June 2013 Actual Primary Completion Date : June 2014 Actual Study Completion Date : July 2014 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Synchronised video-polysomnography Other: Synchronised video-polysomnography We will record (...) : Layout table for MeSH terms Parkinson Disease Mental Disorders REM Sleep Behavior Disorder Parkinsonian Disorders Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Nervous System Diseases Movement Disorders Neurodegenerative Diseases REM Sleep Parasomnias Parasomnias Sleep Wake Disorders

2013 Clinical Trials

152. MicroRNA Association with Synucleinopathy Conversion in REM Behavior Disorder. (Abstract)

MicroRNA Association with Synucleinopathy Conversion in REM Behavior Disorder. Recently, we reported downregulated circulating levels of the microRNAs miR-19b, miR-29a, and miR-29c in Parkinson disease. Here we investigated the expression of these microRNAs in serum samples from 56 patients with idiopathic rapid eye movement sleep behavior disorder, before and after their conversion into a synucleinopathy. Compared to controls, we found that the expression level of miR-19b is downregulated (...) in patients with idiopathic rapid eye movement sleep behavior disorder and antedates the diagnosis of Parkinson disease and dementia with Lewy bodies after 4.67 ± 2.61 years of follow-up. Our findings indicate that dysregulation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies.© 2015 American Neurological Association.

2015 Annals of Neurology

153. Diagnostic accuracy of REM sleep behavior disorder screening questionnaires: a meta-analysis

Diagnostic accuracy of REM sleep behavior disorder screening questionnaires: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address (...) A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome, the choice of effect measure, how subgroup variables are stratified etc. In order to assess the robustness of the findings of the meta-analysis, the analyses are re-run using the alternative

2016 PROSPERO

154. REM Sleep Behavior Disorder and Prodromal Neurodegeneration – Where Are We Headed? Full Text available with Trip Pro

REM Sleep Behavior Disorder and Prodromal Neurodegeneration – Where Are We Headed? Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by loss of normal atonia during REM sleep, such that patients appear to act out their dreams. The most important implication of research into this area is that patients with idiopathic RBD are at very high risk of developing synuclein-mediated neurodegenerative disease (Parkinson's disease [PD], dementia with Lewy bodies [DLB (...) ], and multiple system atrophy), with risk estimates that approximate 40-65% at 10 years. Thus, RBD disorder is a very strong feature of prodromal synucleinopathy. This provides several opportunities for future research. First, patients with REM sleep behavior disorder can be studied to test other predictors of disease, which could potentially be applied to the general population. These studies have demonstrated that olfactory loss, decreased color vision, slowing on quantitative motor testing, and abnormal

2013 Tremor and Other Hyperkinetic Movements

155. Subtle gait changes in patients with REM sleep behavior disorder. Full Text available with Trip Pro

Subtle gait changes in patients with REM sleep behavior disorder. Many people with rapid eye movement (REM) sleep behavior disorder (RBD) have an underlying synucleinopathy, the most common of which is Lewy body disease. Identifying additional abnormal clinical features may help in identifying those at greater risk of evolving to a more severe syndrome. Because gait disorders are common in the synucleinopathies, early abnormalities in gait in those with RBD could help in identifying those (...) at increased risk of developing overt parkinsonism and/or cognitive impairment. We identified 42 probable RBD subjects and 492 controls using the Mayo Sleep Questionnaire and assessed gait velocity, cadence, and stride dynamics with an automated gait analysis system. Cases and controls were similar in age (79.9 ± 4.7 and 80.1 ± 4.7, P = 0.74), Unified Parkinson's Disease Rating Scale Part III (UPDRS) score (3.3 ± 5.5 and 1.9 ± 4.1, P = 0.21) and Mini-Mental State Examination scores (27.2 ± 1.9 and 27.7

2013 Movement Disorders Controlled trial quality: uncertain

156. MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies. Full Text available with Trip Pro

MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies. To determine structural MRI and digital microscopic characteristics of REM sleep behavior disorder in individuals with low-, intermediate-, and high-likelihood dementia with Lewy bodies (DLB) at autopsy.Patients with autopsy-confirmed low-, intermediate-, and high-likelihood DLB, according to the probability statement recommended by the third report of the DLB Consortium, and antemortem MRI, were identified (n = 75 (...) ). The clinical history was assessed for presence (n = 35) and absence (n = 40) of probable REM sleep behavior disorder (pRBD), and patients' antemortem MRIs were compared using voxel-based morphometry. Pathologic burdens of phospho-tau, β-amyloid, and α-synuclein were measured in regions associated with early neuropathologic involvement, the hippocampus and amygdala.pRBD was present in 21 patients (60%) with high-likelihood, 12 patients (34%) with intermediate-likelihood, and 2 patients (6%) with low

2013 Neurology

157. Plasma urate in REM sleep behavior disorder. Full Text available with Trip Pro

Plasma urate in REM sleep behavior disorder. Rapid eye movement (REM) sleep behavior disorder (RBD) is associated with a high risk of developing Parkinson's disease (PD). Higher urate levels are associated with a lower risk of PD. We conducted a study to evaluate plasma urate levels in patients with RBD and their role in the development of PD.We evaluated plasma urate levels in a cohort of 24 patients with idiopathic RBD. Patients were divided into 2 groups according to the presence or absence (...) exhibited higher levels of uric acid than patients with PD (P=0.02).Higher levels of plasma urate were associated with a longer duration of RBD without converting to PD. Future prospective studies would be needed to confirm this finding. Disorder SocietyCopyright © 2013 Movement Disorder Society.

2013 Movement Disorders

158. The Co-Occurrence of Sexsomnia, Sleep Bruxism and Other Sleep Disorders Full Text available with Trip Pro

The Co-Occurrence of Sexsomnia, Sleep Bruxism and Other Sleep Disorders Sleep sex also known as sexsomnia or somnambulistic sexual behavior is proposed to be classified as NREM (non-rapid eye movement) parasomnia (as a clinical subtype of disorders of arousal from NREM sleep-primarily confusional arousals or less commonly sleepwalking), but it has also been described in relation to REM (rapid eye movement) parasomnias.The authors searched the PubMed database to identify relevant publications (...) and present the co-occurrence of sexsomnia and other sleep disorders as a non-systematic review with case series.In the available literature the comorbidity of sexsomnia and other sleep disorders were reported mainly in case reports and less in case series. Sexsomnia was reported both with one and with multiple sleep-related disorders, with NREM parasomnias and obstructive sleep apnea (OSA) being the most commonly reported. Furthermore, the authors enrich the article with new findings concerning two novel

2018 Journal of clinical medicine

159. Idiopathic rapid eye movement sleep behaviour disorder: a potential gateway to the development of disease-modifying treatments in neurodegenerative disorders Full Text available with Trip Pro

Idiopathic rapid eye movement sleep behaviour disorder: a potential gateway to the development of disease-modifying treatments in neurodegenerative disorders 27416855 2017 04 11 2017 04 11 1432-1459 263 8 2016 Aug Journal of neurology J. Neurol. Idiopathic rapid eye movement sleep behaviour disorder: a potential gateway to the development of disease-modifying treatments in neurodegenerative disorders. 1678-80 10.1007/s00415-016-8235-8 Peall K J KJ Institute of Psychological Medicine (...) and Clinical Neuroscience, University Hospital of Wales, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK. Robertson N R NR Institute of Psychological Medicine and Clinical Neuroscience, University Hospital of Wales, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK. robertsonnp@cardiff.ac.uk. eng Journal Article Review Germany J Neurol 0423161 0340-5354 IM Aged Aged, 80 and over Female Humans Male Middle Aged Neurodegenerative Diseases complications therapy Polysomnography REM Sleep Behavior

2016 Journal of neurology

160. Attenuated heart rate response in REM sleep behavior disorder and Parkinson's disease. (Abstract)

Attenuated heart rate response in REM sleep behavior disorder and Parkinson's disease. The objective of this study was to determine whether patients with Parkinson's disease with and without rapid-eye-movement sleep behavior disorder and patients with idiopathic rapid-eye-movement sleep behavior disorder have an attenuated heart rate response to arousals or to leg movements during sleep compared with healthy controls. Fourteen and 16 Parkinson's patients with and without rapid-eye-movement (...) experienced in Parkinson's disease. The idiopathic rapid-eye-movement sleep behavior disorder patients not only exhibited impaired motor symptoms but also incipient autonomic dysfunction, as revealed by the attenuated heart rate response.Copyright © 2012 Movement Disorder Society.

2012 Movement Disorders

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