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REM Sleep Behavior Disorder

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121. REM Sleep Behavior Disorder (Overview)

REM Sleep Behavior Disorder (Overview) REM Sleep Behavior Disorder: Background, Etiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODY1MS1vdmVydmlldw== processing > REM Sleep Behavior (...) Disorder Updated: Mar 11, 2019 Author: Syed M S Ahmed, MD; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections REM Sleep Behavior Disorder Overview Background Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disorder characterized by the loss of normal voluntary muscle atonia during REM sleep, in association with complex motor behavior while dreaming. [ , , , ] Diagnostic Criteria (DSM-5 and ICSD-2) The specific DSM-5 criteria for rapid eye movement

2014 eMedicine.com

122. MicroRNA Association with Synucleinopathy Conversion in REM Behavior Disorder. (PubMed)

MicroRNA Association with Synucleinopathy Conversion in REM Behavior Disorder. Recently, we reported downregulated circulating levels of the microRNAs miR-19b, miR-29a, and miR-29c in Parkinson disease. Here we investigated the expression of these microRNAs in serum samples from 56 patients with idiopathic rapid eye movement sleep behavior disorder, before and after their conversion into a synucleinopathy. Compared to controls, we found that the expression level of miR-19b is downregulated (...) in patients with idiopathic rapid eye movement sleep behavior disorder and antedates the diagnosis of Parkinson disease and dementia with Lewy bodies after 4.67 ± 2.61 years of follow-up. Our findings indicate that dysregulation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies.© 2015 American Neurological Association.

2015 Annals of Neurology

123. MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies. (Full text)

MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies. To determine structural MRI and digital microscopic characteristics of REM sleep behavior disorder in individuals with low-, intermediate-, and high-likelihood dementia with Lewy bodies (DLB) at autopsy.Patients with autopsy-confirmed low-, intermediate-, and high-likelihood DLB, according to the probability statement recommended by the third report of the DLB Consortium, and antemortem MRI, were identified (n = 75 (...) ). The clinical history was assessed for presence (n = 35) and absence (n = 40) of probable REM sleep behavior disorder (pRBD), and patients' antemortem MRIs were compared using voxel-based morphometry. Pathologic burdens of phospho-tau, β-amyloid, and α-synuclein were measured in regions associated with early neuropathologic involvement, the hippocampus and amygdala.pRBD was present in 21 patients (60%) with high-likelihood, 12 patients (34%) with intermediate-likelihood, and 2 patients (6%) with low

2013 Neurology

124. Subtle gait changes in patients with REM sleep behavior disorder. (Full text)

Subtle gait changes in patients with REM sleep behavior disorder. Many people with rapid eye movement (REM) sleep behavior disorder (RBD) have an underlying synucleinopathy, the most common of which is Lewy body disease. Identifying additional abnormal clinical features may help in identifying those at greater risk of evolving to a more severe syndrome. Because gait disorders are common in the synucleinopathies, early abnormalities in gait in those with RBD could help in identifying those (...) at increased risk of developing overt parkinsonism and/or cognitive impairment. We identified 42 probable RBD subjects and 492 controls using the Mayo Sleep Questionnaire and assessed gait velocity, cadence, and stride dynamics with an automated gait analysis system. Cases and controls were similar in age (79.9 ± 4.7 and 80.1 ± 4.7, P = 0.74), Unified Parkinson's Disease Rating Scale Part III (UPDRS) score (3.3 ± 5.5 and 1.9 ± 4.1, P = 0.21) and Mini-Mental State Examination scores (27.2 ± 1.9 and 27.7

2013 Movement Disorders Controlled trial quality: uncertain

125. Questionnaire-based diagnosis of REM sleep behavior disorder in Parkinson's disease. (PubMed)

Questionnaire-based diagnosis of REM sleep behavior disorder in Parkinson's disease. Rapid eye movement (REM) sleep behavior disorder (RBD) is present in around 40% of Parkinson's disease (PD) patients. Definitive diagnosis requires a polysomnogram, but that is costly, time intensive, and not practical for large-scale studies. Therefore, we assessed using a questionnaire-based diagnostic approach.The patient-administered RBD questionnaire and bed-partner-administered question 1 of the Mayo (...) questionnaire were prospectively validated.Seventy-five PD patients (51 male, 68 Hoehn and Yahr stages I and II) participated. Forty-eight had a clinical history of RBD. Sensitivity was 100% (95% CI, 86.3%-100%) when a combination of both questionnaires was compared with the gold standard of polysomnogram-confirmed RBD. Among those who achieved REM sleep (n=65), specificity was highest for the patient questionnaire used alone, at 82.4% (95% CI, 64.8%-92.6%).A combination of patient and bed-partner

2013 Movement Disorders

126. Plasma urate in REM sleep behavior disorder. (Full text)

Plasma urate in REM sleep behavior disorder. Rapid eye movement (REM) sleep behavior disorder (RBD) is associated with a high risk of developing Parkinson's disease (PD). Higher urate levels are associated with a lower risk of PD. We conducted a study to evaluate plasma urate levels in patients with RBD and their role in the development of PD.We evaluated plasma urate levels in a cohort of 24 patients with idiopathic RBD. Patients were divided into 2 groups according to the presence or absence (...) exhibited higher levels of uric acid than patients with PD (P=0.02).Higher levels of plasma urate were associated with a longer duration of RBD without converting to PD. Future prospective studies would be needed to confirm this finding. Disorder SocietyCopyright © 2013 Movement Disorder Society.

2013 Movement Disorders

127. REM Sleep Behavior Disorder and Prodromal Neurodegeneration – Where Are We Headed? (Full text)

REM Sleep Behavior Disorder and Prodromal Neurodegeneration – Where Are We Headed? Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by loss of normal atonia during REM sleep, such that patients appear to act out their dreams. The most important implication of research into this area is that patients with idiopathic RBD are at very high risk of developing synuclein-mediated neurodegenerative disease (Parkinson's disease [PD], dementia with Lewy bodies [DLB (...) ], and multiple system atrophy), with risk estimates that approximate 40-65% at 10 years. Thus, RBD disorder is a very strong feature of prodromal synucleinopathy. This provides several opportunities for future research. First, patients with REM sleep behavior disorder can be studied to test other predictors of disease, which could potentially be applied to the general population. These studies have demonstrated that olfactory loss, decreased color vision, slowing on quantitative motor testing, and abnormal

2013 Tremor and Other Hyperkinetic Movements

128. REM sleep behavior disorder in Parkinson's disease: A case from India confirmed with polysomnographic data (Full text)

REM sleep behavior disorder in Parkinson's disease: A case from India confirmed with polysomnographic data Rapid eye movement (REM) sleep behavior disorder is a condition characterized by dream enactment. This condition may accompany neurodegenerative disorders. However, only a few reports from India are available, that too, without any polysomnographic evidence. We are reporting a case of REM sleep behavior disorder with polysomnographic evidence.

2013 Journal of neurosciences in rural practice

129. Parasomnia Overlap Disorder with Sexual Behaviors during Sleep in a Patient with Obstructive Sleep Apnea (Full text)

, sleeptalking, and REM sleep behavior disorder (RBD). Confusional arousals and RBD were documented during the vPSG. This case had the added complexity of obstructive sleep apnea (OSA) playing a role in sleepwalking and sleep related eating, with good response to nasal continuous positive airway pressure (nCPAP). The sexsomnia did not respond to nCPAP but responded substantially to bedtime clonazepam therapy.© 2016 American Academy of Sleep Medicine. (...) Parasomnia Overlap Disorder with Sexual Behaviors during Sleep in a Patient with Obstructive Sleep Apnea Sleep-related abnormal sexual behaviors (sexsomnia) are classified as a subtype of NREM sleep parasomnias. Sexsomnia has been reported as part of parasomnia overlap disorder (POD) in two other patients. We present the case of a 42-year-old male patient with video-polysomnography (vPSG) documented POD. The patient had sleepwalking, sleep-related eating, confusional arousals, sexsomnia

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

130. REM Sleep Behavior Disorder

REM Sleep Behavior Disorder REM Sleep Behavior Disorder Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 REM Sleep Behavior Disorder (...) REM Sleep Behavior Disorder Aka: REM Sleep Behavior Disorder From Related Chapters II. Epidemiology More common in men than women III. Signs Increased motor tone during sleep Patient acts out dreams during Flails limbs Vocalizes May fall out of bed IV. Complications Risk of injury to patient or bed partner V. Associated Conditions (and related s) Spinocerebellar Severe s VI. Diagnosis VII. Management Treat underlying causes (e.g. , , discontinue causative medications) Remove fragile or dangerous

2015 FP Notebook

131. Long-Term Follow-up Investigation of Isolated Rapid Eye Movement Sleep Without Atonia Without Rapid Eye Movement Sleep Behavior Disorder: A Pilot Study (Full text)

Long-Term Follow-up Investigation of Isolated Rapid Eye Movement Sleep Without Atonia Without Rapid Eye Movement Sleep Behavior Disorder: A Pilot Study Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a harbinger of synuclein-mediated neurodegenerative diseases. It is unknown if this also applies to isolated REM sleep without atonia (RWA). We performed a long-term follow-up investigation of subjects with isolated RWA.Participants were recruited from 50 subjects with isolated (...) RWA who were identified at the sleep laboratory of the Department of Neurology at the Medical University of Innsbruck between 2003 and 2005. Eligible subjects underwent follow-up clinical examination, polysomnography, and assessment of neurodegenerative biomarkers (cognitive impairment, finger speed deficit, impaired color vision, olfactory dysfunction, orthostatic hypotension, and substantia nigra hyperechogenicity).After a mean of 8.6 ± 0.9 y, 1 of 14 participating subjects (7.3%) progressed

2015 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

132. Characteristics of REM Sleep Behavior Disorder in Childhood (Full text)

Characteristics of REM Sleep Behavior Disorder in Childhood To describe our experience regarding the clinical and polysomnographic features of REM sleep behavior disorder (RBD) in childhood.This was a retrospective chart review of children and adolescents with RBD and REM sleep without atonia. Demographics, and clinical and polysomnographic information were tabulated. Our findings were compared with those in the existing literature.The 15 subjects identified (13 RBD and 2 having REM sleep (...) ), and Moebius Syndrome (1/15). Abnormal MRI scans were seen in 5/8 evaluated subjects. Treatments consisted of clonazepam (10/15), melatonin (2/15), and discontinuation of a tricyclic agent (1/15), with a favorable response in 11 of 13. Two of 15 patients with REM sleep without atonia did not require pharmacotherapy.RBD in children may be associated with neurodevelopmental disabilities, narcolepsy, or medication use. It seems to be modestly responsive to benzodiazepines or melatonin. The etiology

2012 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

133. Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study. (Full text)

Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study. Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder.Cases were patients with idiopathic REM sleep behavior disorder who were free (...) of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors.A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0% were

2012 Neurology

134. Hiding in plain sight: Risk factors for REM sleep behavior disorder. (PubMed)

Hiding in plain sight: Risk factors for REM sleep behavior disorder. 22744669 2012 10 12 2018 12 01 1526-632X 79 5 2012 Jul 31 Neurology Neurology Hiding in plain sight: risk factors for REM sleep behavior disorder. 402-3 10.1212/WNL.0b013e31825dd3c0 Sullivan Shannon S SS Schenck Carlos H CH Guilleminault Christian C eng Editorial Comment 2012 06 27 United States Neurology 0401060 0028-3878 AIM IM Neurology. 2012 Jul 31;79(5):428-34 22744670 Environment Female Humans Life Style Male REM Sleep (...) Behavior Disorder etiology 2012 6 30 6 0 2012 6 30 6 0 2012 10 13 6 0 ppublish 22744669 WNL.0b013e31825dd3c0 10.1212/WNL.0b013e31825dd3c0

2012 Neurology

135. REM sleep behavior disorder: Motor manifestations and pathophysiology. (PubMed)

REM sleep behavior disorder: Motor manifestations and pathophysiology. Patients with REM sleep behavior disorder (RBD) enact violent dreams during REM sleep in the absence of normal muscle atonia. This disorder is highly frequent in patients with synucleinopathies (60%-100% of patients) and rare in patients with other neurodegenerative disorders. The disorder is detected by interview plus video and sleep monitoring. Abnormal movements expose the patients and bed partners to a high risk (...) of injury and sleep disruption. The disorder is usually alleviated with melatonin and clonazepam. Limb movements are mainly minor, jerky, fast, pseudohallucinatory, and repeated, with a limp wrist during apparently grasping movements, although body jerks and complex violent (fights) and nonviolent culturally acquired behaviors are also observed. Notably, parkinsonism disappears during RBD-associated complex behaviors in patients with Parkinson's disease and with multiple system atrophy, suggesting

2012 Movement Disorders

136. Attenuated heart rate response in REM sleep behavior disorder and Parkinson's disease. (Full text)

Attenuated heart rate response in REM sleep behavior disorder and Parkinson's disease. The objective of this study was to determine whether patients with Parkinson's disease with and without rapid-eye-movement sleep behavior disorder and patients with idiopathic rapid-eye-movement sleep behavior disorder have an attenuated heart rate response to arousals or to leg movements during sleep compared with healthy controls. Fourteen and 16 Parkinson's patients with and without rapid-eye-movement (...) sleep behavior disorder, respectively, 11 idiopathic rapid-eye-movement sleep behavior disorder patients, and 17 control subjects underwent 1 night of polysomnography. The heart rate response associated with arousal or leg movement from all sleep stages was analyzed from 10 heartbeats before the onset of the sleep event to 15 heartbeats following onset of the sleep event. The heart rate reponse to arousals was significantly lower in both parkinsonian groups compared with the control group

2012 Movement Disorders

137. Validation of the Innsbruck REM sleep behavior disorder inventory. (PubMed)

Validation of the Innsbruck REM sleep behavior disorder inventory. A diagnosis of definite REM sleep behavior disorder requires both a positive history for REM sleep behavior disorder and polysomnographic demonstration of REM sleep without atonia. To improve and facilitate screening for REM sleep behavior disorder, there is a need for simple clinical tools with sufficient sensitivity and specificity for the identification of subjects with probable REM sleep behavior disorder. We developed (...) a short REM sleep behavior disorder screening questionnaire with 7 REM sleep behavior disorder- and 2 non-REM sleep behavior disorder-specific control items and performed a validation study in 70 REM sleep behavior disorder subjects and 140 sleep disorder controls. Response patterns to all 7 REM sleep behavior disorder-specific items differed between REM sleep behavior disorder and non-REM sleep behavior disorder patients (all P < 0.05), whereas the 2 non-REM sleep behavior disorder-specific control

2012 Movement Disorders

138. Unimpaired postprandial pancreatic polypeptide secretion in Parkinson's disease and REM sleep behavior disorder. (PubMed)

Unimpaired postprandial pancreatic polypeptide secretion in Parkinson's disease and REM sleep behavior disorder. Pancreatic polypeptide is released immediately after food ingestion. The release is operated by vagal-abdominal projections and has therefore been suggested as a test for vagal nerve integrity. Pathoanatomical and clinical studies indicate vagal dysfunction in early Parkinson's disease (PD).We assessed the postprandial secretion of pancreatic polypeptide and motilin in healthy (...) controls (n = 18) and patients with idiopathic rapid-eye-movement sleep behavior disorder (iRBD, n = 10), a potential premotor stage of PD, as well as in drug-naive (n = 19) and treated (n = 19) PD patients.The postprandial pancreatic polypeptide secretion showed a physiological pattern in all groups and even an enhanced response in drug-naive PD and iRBD. Motilin concentrations correlated with pancreatic polypeptide concentrations.Postprandial pancreatic polypeptide secretion is not a suitable test

2012 Movement Disorders

139. Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder. (PubMed)

Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder. 23243074 2013 02 25 2012 12 25 1526-632X 80 1 2013 Jan 01 Neurology Neurology Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder. 118-20 10.1212/WNL.0b013e31827b1b2a Flanagan Eoin P EP Department of Neurology, Mayo Clinic, Rochester, MN, USA. Gavrilova Ralitza H RH Boeve Bradley F BF Kumar Neeraj N Jelsing Elena J EJ Silber Michael H MH eng Case Reports Journal (...) Article 2012 12 12 United States Neurology 0401060 0028-3878 Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant AIM IM Brain Waves physiology Humans Magnetic Resonance Imaging methods psychology Male Middle Aged Pelizaeus-Merzbacher Disease complications diagnosis physiopathology Polysomnography methods psychology REM Sleep Behavior Disorder complications diagnosis physiopathology 2012 12 18 6 0 2012 12 18 6 0 2013 2 26 6 0 ppublish 23243074 WNL.0b013e31827b1b2a 10.1212/WNL

2012 Neurology

140. Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder. (Full text)

Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder. Patients with idiopathic REM sleep behavior disorder (IRBD) are at risk for developing Parkinson disease (PD) and dementia with Lewy bodies (DLB). We aimed to identify functional brain imaging patterns predicting the emergence of PD and DLB in patients with IRBD, using SPECT with (99m)Tc-ethylene cysteinate dimer (ECD).Twenty patients with IRBD were scanned at baseline during wakefulness using (99m)Tc-ECD (...) in this process.Of the 20 patients with IRBD recruited for this study, 10 converted to PD or DLB during the follow-up. rCBF at baseline was increased in the hippocampus of patients who would later convert compared with those who would not (p < 0.05 corrected). Hippocampal perfusion was correlated with motor and color vision scores across all IRBD patients.(99m)Tc-ECD SPECT identifies patients with IRBD at risk for conversion to other neurodegenerative disorders such as PD or DLB; disease progression in IRBD

2012 Neurology

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