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REM Sleep Behavior Disorder

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121. Sleep-disordered Breathing in Patients with COPD

, 2’ EEG Right leg Left leg P-Snoring Snoring P-Flow Rib cage ECG O2 saturation (%) 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 93 93 93 93 93 93 93 Inspiratory Expiratory 10 Seconds Figure 4. Expiratory ?ow limitation and expiratory snoring in chronic obstructive pulmonary disease. A representative polysomnograph recording during non-REM sleep in a patient with sleep-disordered breathing and obstructive lung disease (...) American Thoracic Society Documents 289 Overview The overlap syndrome (OVS) is the co-occurrence of chronic obstructive pulmonarydisease (COPD)and obstructive sleep apnea (OSA). This statement summarizestheexistingliterature,identi?es knowledge gaps, and provides guidance regarding future priorities in research for sleep-disordered breathing (SDB) in patientswithCOPDandotherlungdiseases. Key Conclusions d OVS is common because COPD and OSA are common. There is no de?nitive evidence that patients

2018 American Thoracic Society

122. Gait and REM Sleep Behavior Disorder

Information provided by (Responsible Party): University Hospital, Montpellier Study Details Study Description Go to Brief Summary: Many people with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) have an underlying synucleinopathy, the most common of which are Parkinson's disease (PD) and Lewy body disease. Identifying additional abnormal clinical features may help in identifying those at greater risk of evolving to a more severe syndrome. Because gait disorders are common (...) Intervention/treatment Phase Parkinson's Disease REM Sleep Behavior Disorder Radiation: FP-CIT single-photon emission computed tomography Behavioral: neuropsychological evaluation Other: Gait recording with sensors Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 63 participants Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Diagnostic Official Title

2015 Clinical Trials

123. Management of REM sleep behavior disorder: An evidence based review Full Text available with Trip Pro

Management of REM sleep behavior disorder: An evidence based review Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by dream enactment behavior resulting from a loss of REM skeletal muscle atonia. The neurobiology of REM sleep and the characteristic features of REM atonia have an important basis for understanding the aggravating etiologies the proposed pharmacological interventions in its management. This review outlines the evidence for behavioral and therapeutic (...) such as falls and provides a base for intervention with neuroprotective mechanisms and allocates a unique platform that RBD portrays with its high risk of disease conversion with a sufficiently long latency. RBD provides a unique platform with its high risk of disease conversion with a sufficiently long latency, providing an opportunity for early intervention both to prevent consequences such as falls and provide a base for intervention with neuroprotective mechanisms.

2015 Annals of Indian Academy of Neurology

124. A new view of "dream enactment" in REM sleep behavior disorder. Full Text available with Trip Pro

A new view of "dream enactment" in REM sleep behavior disorder. Patients with REM sleep behavior disorder (RBD) exhibit increased muscle tone and exaggerated myoclonic twitching during REM sleep. In addition, violent movements of the limbs, and complex behaviors that can sometimes appear to involve the enactment of dreams, are associated with RBD. These behaviors are widely thought to result from a dysfunction involving atonia-producing neural circuitry in the brainstem, thereby unmasking (...) cortically generated dreams. Here we scrutinize the assumptions that led to this interpretation of RBD. In particular, we challenge the assumption that motor cortex produces twitches during REM sleep, thus calling into question the related assumption that motor cortex is primarily responsible for all of the pathological movements of RBD. Moreover, motor cortex is not even necessary to produce complex behavior; for example, stimulation of some brainstem structures can produce defensive and aggressive

2015 Sleep medicine reviews

125. REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers. Full Text available with Trip Pro

REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers. Rapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2-PD and utility as a preclinical marker has not been established.One hundred forty-four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non-manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior (...) in LRRK2-PD, especially in early LRRK2-PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD.© 2015 International Parkinson and Movement Disorder Society.

2015 Movement Disorders

126. Nigro-caudate dopaminergic deafferentation: a marker of REM sleep behavior disorder? (Abstract)

Nigro-caudate dopaminergic deafferentation: a marker of REM sleep behavior disorder? Forty-nine consecutive, drug naïve outpatients with de novo Parkinson's disease (PD) and 12 patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) underwent clinical examination and dopamine transporter single photon emission computed tomography with [(123)I]-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane as a biomarker of nigro-striatal function. PD patients were grouped (...) into rapid eye movement sleep behavior disorder (RBD) negative (PD-RBD-) and RBD positive (PD-RBD+). Repeated measures and univariate analysis of variance were used to compare dopaminergic and clinical impairment among groups. The variations of dopamine transporter-single photon emission computed tomography specific binding ratios (SBR) as a function of group belonging were significantly different (p = 0.0013) at caudate with respect to putamen level. Indeed, putamen SBR progressively decreased from iRBD

2015 Neurobiology of Aging

127. Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder. Full Text available with Trip Pro

Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder. To investigate the expression of α-synuclein in colonic biopsies of patients with idiopathic REM sleep behavior disorder (iRBD) and address if α-synuclein immunostaining of tissue obtained via colonic biopsies holds promise as a diagnostic biomarker for prodromal Parkinson disease (PD).Patients with iRBD, patients with PD, and healthy controls were prospectively recruited to undergo colonic biopsies

2015 Neurology

128. Reduced striatal dopamine transmission in REM sleep behavior disorder comorbid with depression. (Abstract)

Reduced striatal dopamine transmission in REM sleep behavior disorder comorbid with depression. To investigate dopamine transmission in patients with comorbid REM sleep behavior disorder (RBD) and major depressive disorder (MDD).This is a case-control study including 11 medicated patients with comorbid RBD and MDD (mean age 47.5 ± 8.2), 8 medicated patients with MDD only (mean age 47.9 ± 8.4), and 10 healthy participants (mean age 46.5 ± 10.6 years). They underwent clinical assessment, video (...) < 0.01) and REM-related tonic muscle activity (p < 0.01). The comorbid RBD and MDD group had more impairment in olfactory function.Patients with comorbid RBD and MDD had presynaptic dopamine dysfunction and impaired olfactory function. There is a distinct possibility that the development of RBD symptoms among patients with MDD may represent an early phase of α-synucleinopathy neurodegeneration instead of a merely antidepressant-induced condition.© 2015 American Academy of Neurology.

2015 Neurology

129. Odor Identification Test in Idiopathic REM-Behavior Disorder and Parkinson's Disease in China Full Text available with Trip Pro

Odor Identification Test in Idiopathic REM-Behavior Disorder and Parkinson's Disease in China Olfactory dysfunction is common in Parkinson's disease (PD) and idiopathic rapid eye movement sleep behavior disorder (iRBD), which is a risk factor in the development of PD. However, a few studies have conflicting results when comparing dysosmia in the patients with iRBD and PD. There is no study investigating the olfactory function in Chinese patients with iRBD. Additionally, the Sniffin' Sticks

2016 PloS one

130. REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. (Abstract)

REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. Rapid eye movement (REM) sleep behavior disorder (RBD) is commonly associated with Lewy body disease, narcolepsy, or depression. In contrast, the relationship between REM sleep without atonia (RWA), which is a hallmark of RBD on polysomnography, and clinical characteristics remains unclear. The purpose of this study is to investigate the clinical features of psychiatric patients (...) exhibiting RWA and its relevance to Lewy body disease.Of 55 consecutive patients who underwent polysomnography at the psychiatric ward, 25 patients with sleep apnea syndrome were excluded, and 12 patients exhibiting RWA were identified. The clinical profiles were compared between the groups with and without RWA.The mean age and the frequency of neurocognitive disorders were significantly higher in 12 patients with RWA than in 18 without. Only five of the 12 patients exhibiting RWA had episodes of dream

2017 International Journal of Geriatric Psychiatry

131. Sociality Affects REM Sleep Episode Duration Under Controlled Laboratory Conditions in the Rock Hyrax, Procavia capensis Full Text available with Trip Pro

Sociality Affects REM Sleep Episode Duration Under Controlled Laboratory Conditions in the Rock Hyrax, Procavia capensis The rock hyrax, Procavia capensis, is a highly social, diurnal mammal. In the current study several physiologically measurable parameters of sleep, as well as the accompanying behavior, were recorded continuously from five rock hyraxes, for 72 h under solitary (experimental animal alone in the recording chamber), and social conditions (experimental animal with 1 or 2 (...) additional, non-implanted animals in the recording chamber). The results revealed no significant differences between solitary and social conditions for total sleep times, number of episodes, episode duration or slow wave activity (SWA) for all states examined. The only significant difference observed between social and solitary conditions was the average duration of rapid eye movement (REM) sleep episodes. REM sleep episode duration was on average 20 s and 40 s longer under social conditions daily

2017 Frontiers in neuroanatomy

132. Opposite Impact of REM Sleep on Neurobehavioral Functioning in Children with Common Psychiatric Disorders Compared to Typically Developing Children Full Text available with Trip Pro

functions in children with common developmental psychiatric conditions compared to typically developing children (TDC). Twenty-four children with attention-deficit/hyperactivity disorder (ADHD), 21 with Tourette syndrome/tic disorder (TD), 21 with ADHD/TD comorbidity, and 22 TDC, matched for age and gender, underwent a two-night PSG, and their psychopathological scores and intelligence quotient (IQ) were assessed. Major PSG findings showed more REM sleep and shorter REM latency in the children (...) Opposite Impact of REM Sleep on Neurobehavioral Functioning in Children with Common Psychiatric Disorders Compared to Typically Developing Children Rapid eye movement (REM) sleep has been shown to be related to many adaptive cognitive and behavioral functions. However, its precise functions are still elusive, particularly in developmental psychiatric disorders. The present study aims at investigating associations between polysomnographic (PSG) REM sleep measurements and neurobehavioral

2017 Frontiers in psychology

133. A Meta-Analysis of Sleep Disturbances in Panic Disorder Full Text available with Trip Pro

of patients primarily experience nocturnal panic attacks [ ], and cases of individuals with exclusively nocturnal panic attacks have been reported [ ]. Nocturnal panic attacks can be assessed using the NPA appendix from the anxiety disorders interview schedule for DSM-IV. This clinician-administered interview thoroughly assesses NPA and includes questions relating to NPA frequency, apprehensiveness about future NPA, and avoidance behaviors. 1.3 Why study sleep in panic disorder? Disturbed sleep (...) was used to design the study and to report results based on best practices in the field of literature reviews and meta-analyses [ ]. 2.1 Literature research We conducted a literature review in these databases: PsycNet, MedLine, ProQuest, Web of Knowledge, Cochrane, and Psychology and Behavioral Sciences Collection. Search terms used in PsycNet were “panic disorder” OR “panic attack” OR panic AND sleep OR “sleep disorders” OR insomnia OR “nocturnal panic” OR “sleep deprivation.” Search terms used

2020 Psychopathology - An International and Interdisciplinary Perspective

134. Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. Full Text available with Trip Pro

Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. To determine if sleep talkers with REM sleep behavior disorder (RBD) would utter during REM sleep sentences learned before sleep, and to evaluate their verbal memory consolidation during sleep.Eighteen patients with RBD and 10 controls performed two verbal memory tasks (16 words from the Free and Cued Selective Reminding Test and a 220-263 word long modified Story (...) consolidation was maintained in patients with RBD (+24±36% words) as in controls (+9±18%, p=0.3). The two demented patients with RBD also exhibited excellent nighttime consolidation. The post-sleep performance was unrelated to the sleep measures (including continuity, stages, fragmentation and apnea-hypopnea index). Daytime consolidation (-9±19%) was worse than night-time consolidation (+29±45%, p=0.03) in the subgroup of 9 patients with RBD. Eleven patients with RBD spoke during REM sleep and pronounced

2013 PloS one Controlled trial quality: uncertain

135. Actigraphy as a diagnostic aid for REM sleep behavior disorder in Parkinson's disease. Full Text available with Trip Pro

Actigraphy as a diagnostic aid for REM sleep behavior disorder in Parkinson's disease. Rapid eye movement (REM) sleep behavior disorder (RBD) is a common parasomnia in Parkinson's disease (PD) patients. The current International Classification of Sleep Disorders (ICSD-II) requires a clinical interview combined with video polysomnography (video-PSG) to diagnose. The latter is time consuming and expensive and not always feasible in clinical practice. Here we studied the use of actigraphy

2014 BMC Neurology

136. Does Postural Rigidity Decrease during REM Sleep without Atonia in Parkinson Disease? Full Text available with Trip Pro

Does Postural Rigidity Decrease during REM Sleep without Atonia in Parkinson Disease? Rigidity is a muscle hypertonia typical of Parkinson disease (PD), whereas rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by abnormally increased muscle tone during REM sleep (REM sleep without atonia) and enacting dream behaviors. Because movements are not bradykinetic during RBD in patients with PD, we investigated whether the background, wake postural rigidity is attenuated during (...) REM sleep without atonia, in absence of movement.The amplitude of levator menti (postural muscle) electromyographic activity during relaxed evening wakefulness (considered as reference) and sleep (N2, N3, atonic REM sleep, and quiet REM sleep without atonia) was measured in 20 patients with PD (with and without RBD), 10 patients with idiopathic RBD patients and 10 healthy subjects.The chin tone amplitude progressively decreased from wake to N2, N3, and atonic REM sleep in the four groups

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

137. Conditioning of amitriptyline-induced REM sleep suppression in healthy participants: A randomized controlled trial. (Abstract)

Conditioning of amitriptyline-induced REM sleep suppression in healthy participants: A randomized controlled trial. Clinical trials in sleep disorders report substantial improvement in symptoms in their placebo groups. Behavioral conditioning is one of the underlying mechanisms of the placebo response. However, we do not know whether, and if so, the extent to which sleep architecture is influenced by behavioral conditioning, similarly to other physiological responses (i.e., those in the immune (...) system). We therefore applied a conditioning paradigm to 39 healthy adults pairing a novel-tasting drink (conditioned stimulus, CS) with the REM sleep suppressing tricyclic antidepressant amitriptyline as unconditioned stimulus during the acquisition phase. Subsequent sole presentation of the CS (together with a placebo pill) in an evocation night led to significantly more REM sleep in the amitriptyline group. Instead of the expected REM sleep suppression in the evocation night, we observed more REM

2016 Psychophysiology Controlled trial quality: uncertain

138. Risk factors associated to REM Behaviour Sleep Disorder per se and in relation to Parkinson's Disease: a systematic review

Risk factors associated to REM Behaviour Sleep Disorder per se and in relation to Parkinson's Disease: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence (...) is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome, the choice of effect measure, how subgroup variables are stratified etc. In order to assess the robustness of the findings of the meta-analysis, the analyses

2016 PROSPERO

139. Idiopathic REM sleep behaviour disorder in the development of Parkinson's disease. Full Text available with Trip Pro

Idiopathic REM sleep behaviour disorder in the development of Parkinson's disease. Parkinson's disease is a progressive neurodegenerative disorder associated with Lewy body disease pathology in central and peripheral nervous system structures. Although the cause of Parkinson's disease is not fully understood, clinicopathological analyses have led to the development of a staging system for Lewy body disease-associated pathological changes. This system posits a predictable topography (...) degeneration and the associated parkinsonian features of Parkinson's disease. One such manifestation of prodromal Parkinson's disease is rapid eye movement (REM) sleep behaviour disorder, which is a parasomnia manifested by vivid dreams associated with dream enactment behaviour during REM sleep. Findings from animal and human studies have suggested that lesions or dysfunction in REM sleep and motor control circuitry in the pontomedullary structures cause REM sleep behaviour disorder phenomenology

2013 Lancet Neurology

140. REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease. Full Text available with Trip Pro

REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease. Concomitant REM sleep behaviour disorder (RBD) is commonly observed in patients with Parkinson's disease (PD). Although the brainstem structures responsible for the symptoms of RBD correspond to the premotor stages of PD, the association of RBD with motor and non-motor features in early PD remains unclear.The study evaluated 475 patients with PD within 3.5 years (...) of diagnosis for the presence of probable RBD (pRBD) using the REM Sleep Behaviour Disorder Screening Questionnaire (RBDSQ). A neurologist and a trained research nurse carried out evaluation of each participant blinded to the results of the RBDSQ. Standardised rating scales for motor and non-motor features of PD, as well as health-related quality of life measures, were assessed. Multiple linear and logistic regression analyses were used to determine the relationship between pRBD and a variety of outcomes

2013 Neurosurgery and Psychiatry

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