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REM Sleep Behavior Disorder

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121. Best Practice Guide for the Treatment of REM Sleep Behavior Disorder (RBD)

Best Practice Guide for the Treatment of REM Sleep Behavior Disorder (RBD) R. Nisha Aurora" /> JCSM - Best Practice Guide for the Treatment of REM Sleep Behavior Disorder (RBD) Search article archive here ADVERTISEMENT Current Issue: Volume: 15 Number: 03 Issue Navigator Volume 06 No. 01 .9-10 Charles F. Reynolds III, M.D. 1 ; Susan Redline, M.D. 2 ; for the DSM-V Sleep-Wake Disorders Workgroup and Advisors* .11-17 Nathaniel F. Watson, M.D., M.S. 1 ; Dedra Buchwald, M.D. 2 ; Michael V. Vitiello (...) , of the article without the written permission of the AASM. Further, purchase does not permit the posting of article text on an online forum or website. E-mail Share Slides Please login to download PDF Subscribers can download and print full articles from current and past issues of the JCSM Not a subscriber? and receive a subscription to JCSM with your membership Special Articles Best Practice Guide for the Treatment of REM Sleep Behavior Disorder (RBD) Standards of Practice Committee: R. Nisha Aurora, M.D. 1

2010 American Academy of Sleep Medicine

122. Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. Full Text available with Trip Pro

Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. To determine if sleep talkers with REM sleep behavior disorder (RBD) would utter during REM sleep sentences learned before sleep, and to evaluate their verbal memory consolidation during sleep.Eighteen patients with RBD and 10 controls performed two verbal memory tasks (16 words from the Free and Cued Selective Reminding Test and a 220-263 word long modified Story (...) consolidation was maintained in patients with RBD (+24±36% words) as in controls (+9±18%, p=0.3). The two demented patients with RBD also exhibited excellent nighttime consolidation. The post-sleep performance was unrelated to the sleep measures (including continuity, stages, fragmentation and apnea-hypopnea index). Daytime consolidation (-9±19%) was worse than night-time consolidation (+29±45%, p=0.03) in the subgroup of 9 patients with RBD. Eleven patients with RBD spoke during REM sleep and pronounced

2013 PloS one Controlled trial quality: uncertain

123. Odor Identification Test in Idiopathic REM-Behavior Disorder and Parkinson's Disease in China Full Text available with Trip Pro

Odor Identification Test in Idiopathic REM-Behavior Disorder and Parkinson's Disease in China Olfactory dysfunction is common in Parkinson's disease (PD) and idiopathic rapid eye movement sleep behavior disorder (iRBD), which is a risk factor in the development of PD. However, a few studies have conflicting results when comparing dysosmia in the patients with iRBD and PD. There is no study investigating the olfactory function in Chinese patients with iRBD. Additionally, the Sniffin' Sticks

2016 PloS one

124. Rapid Eye Movement Sleep Behavior Disorder: A Review of the Literature and Update on Current Concepts. (Abstract)

Rapid Eye Movement Sleep Behavior Disorder: A Review of the Literature and Update on Current Concepts. Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by abnormal behaviors emerging during REM sleep that may cause injury or sleep disruption. The diagnosis requires polysomnography (PSG) demonstrating a loss of normal skeletal muscle atonia during REM sleep. RBD results from dysfunction of the brain stem circuits responsible for maintaining normal REM sleep atonia (...) and suppressing behaviors during REM sleep. The diagnosis of idiopathic RBD (IRBD), that is, RBD without an identifiable cause, is frequently followed years later by the development of a neurodegenerative disorder, most commonly one of the synucleinopathies. As such, RBD is often a step in the progression of a neurodegenerative disorder. In this circumstance, it is a manifestation of neurodegeneration occurring in the brain stem before spreading to adjacent and other CNS regions, resulting in the development

2017 Chest

125. Duloxetine-induced rapid eye movement sleep behavior disorder: a case report. Full Text available with Trip Pro

Duloxetine-induced rapid eye movement sleep behavior disorder: a case report. Tricyclic antidepressants and selective serotonin reuptake inhibitors have been reported to induce the symptoms of rapid eye movement (REM) sleep behavior disorder (RBD) or to exacerbate REM sleep without atonia. With this case report, we found an association between typical RBD and duloxetine, a serotonin-noradrenaline reuptake inhibitor.We present a case of a 62-year-old woman who experienced enactment behaviors (...) with violent dreams that were associated with increased tonic or phasic chin electromyography activity during REM sleep after treated with duloxetine. RBD symptoms were gradually reduced and completely ceased after discontinuation of duloxetine for 37 days.The current case appears to be the first observation of duloxetine-induced RBD. We describe features of RBD induced by duloxetine that are similar and different from that induced by tricyclic antidepressants and selective serotonin reuptake inhibitors.

2017 BMC Psychiatry

126. Ambulatory Sleep Study for diagnosing obstructive sleep apnoea

hypoventilation; Significant cardiopulmonary disease; Long-term home oxygen therapy; Chronic opiate medication use; Parasomnias (such as REM behavioural disorder); Severe insomnia; Sleep-related movement disorders (such as periodic limp movement disorder); Potential respiratory muscle weakness caused by neuromuscular conditions; History of stroke; Disorders of central hypersomnolence; Nocturnal seizure; and Environmental or personal factors precluding adequate acquisition and data interpretation from HST (...) obstructive sleep apnoea (OSA) in adults aged ≥18 years who fulfil both (A) and (B) . High pre-test probability for moderate-severe OSA, where signs and symptoms indicating a high pre-test probability for moderate-severe OSA include: Excessive daytime sleepiness; and At least two of the following three criteria: (i) habitual loud snoring; (ii) witnessed apnoea, gasping, or choking; and (iii) diagnosed hypertension No complicated conditions that include: Awake hypoventilation or high risk of sleep-related

2019 Appropriate Care Guides, Agency for Care Effectiveness (Singapore)

127. Sleep Disorder Management Diagnostic & Treatment Guidelines

of OSA would allow avoidance of surgery; OR 8. Suspected congenital central alveolar hypoventilation syndrome or sleep-related hypoventilation due to neuromuscular disease or chest wall deformities; OR 9. Clinical evidence of a sleep-related breathing disorder in infants who have experienced an apparent life-threatening event; OR 10. For exclusion of OSA in a patient who has undergone adenotonsillectomy for suspected OSA more than eight (8) weeks previously; OR 11. The initial study was inadequate (...) terrors ? Rapid eye movement (REM) sleep behavior disorder ? Sleep-related epilepsy ? Sleep bruxism ? Sleep enuresis (bed wetting) ? Periodic limb movement disorder (PLMD) ? Nocturnal oxygen desaturation Polysomnography and Home Sleep TestingPolysomnography and Home Sleep Testing | Copyright © 2017. AIM Specialty Health. All Rights Reserved. 5 Overview Obstructive sleep apnea (OSA) is a common disorder affecting up to 2–4% of the population. Many patients with OSA remain undiagnosed. OSA

2017 AIM Specialty Health

128. Risk factors associated to REM Behaviour Sleep Disorder per se and in relation to Parkinson's Disease: a systematic review

Risk factors associated to REM Behaviour Sleep Disorder per se and in relation to Parkinson's Disease: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence (...) is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome, the choice of effect measure, how subgroup variables are stratified etc. In order to assess the robustness of the findings of the meta-analysis, the analyses

2016 PROSPERO

129. REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease. Full Text available with Trip Pro

REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease. Concomitant REM sleep behaviour disorder (RBD) is commonly observed in patients with Parkinson's disease (PD). Although the brainstem structures responsible for the symptoms of RBD correspond to the premotor stages of PD, the association of RBD with motor and non-motor features in early PD remains unclear.The study evaluated 475 patients with PD within 3.5 years (...) of diagnosis for the presence of probable RBD (pRBD) using the REM Sleep Behaviour Disorder Screening Questionnaire (RBDSQ). A neurologist and a trained research nurse carried out evaluation of each participant blinded to the results of the RBDSQ. Standardised rating scales for motor and non-motor features of PD, as well as health-related quality of life measures, were assessed. Multiple linear and logistic regression analyses were used to determine the relationship between pRBD and a variety of outcomes

2013 Neurosurgery and Psychiatry

130. Idiopathic REM sleep behaviour disorder in the development of Parkinson's disease. Full Text available with Trip Pro

Idiopathic REM sleep behaviour disorder in the development of Parkinson's disease. Parkinson's disease is a progressive neurodegenerative disorder associated with Lewy body disease pathology in central and peripheral nervous system structures. Although the cause of Parkinson's disease is not fully understood, clinicopathological analyses have led to the development of a staging system for Lewy body disease-associated pathological changes. This system posits a predictable topography (...) degeneration and the associated parkinsonian features of Parkinson's disease. One such manifestation of prodromal Parkinson's disease is rapid eye movement (REM) sleep behaviour disorder, which is a parasomnia manifested by vivid dreams associated with dream enactment behaviour during REM sleep. Findings from animal and human studies have suggested that lesions or dysfunction in REM sleep and motor control circuitry in the pontomedullary structures cause REM sleep behaviour disorder phenomenology

2013 Lancet Neurology

131. REM Sleep Behavior and Motor Findings in Parkinson's Disease: A Cross-sectional Analysis Full Text available with Trip Pro

REM Sleep Behavior and Motor Findings in Parkinson's Disease: A Cross-sectional Analysis Parkinson's disease (PD) represents a major public health challenge that will only grow in our aging population. Understanding the connection between PD and associated prodromal conditions, such as rapid eye movement sleep behavioral disorder (RBD), is critical to identifying prevention strategies. However, the relationship between RBD and severity of motor findings in early PD is unknown. This study aims (...) to examine this relationship.The study population consisted of 418 PD patients who completed the Movement Disorders Society-United Parkinson's Disease Rating Scale (MDS-UPDRS) and rapid eye movement sleep (REM) disorder questionnaires at the baseline visit of the Michael J. Fox's Parkinson's Progression Markers Initiative (PPMI). Cross-sectional analysis was carried out to assess the association between REM Sleep Behavior Screening Questionnaire score and MDS UPDRS-3 (motor) score categories. Correlation

2014 Tremor and Other Hyperkinetic Movements

132. Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism

: Ministry of Food and Drug Safety, Korea Information provided by (Responsible Party): BS Jeon, Seoul National University Hospital Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether clonazepam is effective and safe in the treatment of rapid eye movement behavior disorder (RBD) of patients with Parkinson's disease (PD). Condition or disease Intervention/treatment Phase REM Sleep Behavior Disorder Drug: Clonazepam Drug: Placebo Phase 2 Detailed (...) Last Verified: April 2016 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: Undecided Keywords provided by BS Jeon, Seoul National University Hospital: REM Sleep Behavior Disorder Parkinson Disease Placebos Randomized Controlled Trial Double-Blind Method Clinical Trial Additional relevant MeSH terms: Layout table for MeSH terms Disease Mental Disorders Parkinsonian Disorders REM Sleep Behavior Disorder Pathologic Processes Basal Ganglia Diseases Brain Diseases Central Nervous

2014 Clinical Trials

133. Abnormal metabolic network activity in REM sleep behavior disorder. Full Text available with Trip Pro

Abnormal metabolic network activity in REM sleep behavior disorder. To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion.For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy (...) control values.PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r(2) = 0.64, p < 0.0001).Latent network abnormalities

2014 Neurology

134. Five-year follow-up of substantia nigra echogenicity in idiopathic REM sleep behavior disorder. (Abstract)

Five-year follow-up of substantia nigra echogenicity in idiopathic REM sleep behavior disorder. Hyperechogenicity of the substantia nigra visualized by transcranial sonography occurs in most Parkinson's disease (PD) patients. Idiopathic rapid eye movement (REM) sleep behavior disorder (IRBD) subjects eventually develop PD and other synucleinopathies. This study was undertaken to evaluate whether in IRBD, transcranial sonography identifies subjects who convert to PD and other synucleinopathies (...)  = 0.125). Transcranial sonography of the substantia nigra alone is not a useful tool to identify IRBD subjects at risk for the development of PD or a synucleinopathy after 5 years of follow-up. In IRBD, transcranial sonography cannot be used to monitor the degenerative process in the substantia nigra, because echogenicity size remains stable over time.© 2014 International Parkinson and Movement Disorder Society.

2014 Movement Disorders

135. Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke. Full Text available with Trip Pro

Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke. Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disturbance in which patients enact their dreams while in REM sleep. The behavior is typically violent in association with violent dream content, so serious harm can be done to the patient or the bed partner. The prevalence of RBD is well-known in Parkinson's disease, Lewy body dementia, and multiple systems atrophy. However, its prevalence (...) the severity of each stroke using the National Institute of Health Stroke Scale (NIHSS). One hundred and nineteen of the 775 patients meeting study entry criteria formed the study sample. All eligible participants were invited to attend a research clinic 3 months after the onset of the index stroke. In the attendance, a research assistant administered the MMSE and the 13-item RBD questionnaire (RBDQ).Among 119 stroke patients, 10.9% were exhibited RBD, defined as an REM sleep behavior disorder

2014 BMC Neurology

136. Overview of Sleep and Circadian Rhythm Disorders in Parkinson Disease. (Abstract)

specific features of the most common sleep disorders in PD, including insomnia, excessive daytime sleepiness, sleep-disordered breathing, restless legs syndrome, circadian rhythm disorders and REM sleep behavior disorders.Copyright © 2019 Elsevier Inc. All rights reserved. (...) Overview of Sleep and Circadian Rhythm Disorders in Parkinson Disease. Sleep disorders are common among PD patients and affect quality of life. They are often under-recognized and under-treated. Mechanisms of sleep disorders in PD remain relatively poorly understood. Improved awareness of common sleep problems in PD. Tailored treatment and evidence for efficacy are lacking. The purpose of this review is to provide an overview and update on the most common sleep disorders in PD. We review

2020 Clinics in Geriatric Medicine

137. REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. (Abstract)

REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. Rapid eye movement (REM) sleep behavior disorder (RBD) is commonly associated with Lewy body disease, narcolepsy, or depression. In contrast, the relationship between REM sleep without atonia (RWA), which is a hallmark of RBD on polysomnography, and clinical characteristics remains unclear. The purpose of this study is to investigate the clinical features of psychiatric patients (...) exhibiting RWA and its relevance to Lewy body disease.Of 55 consecutive patients who underwent polysomnography at the psychiatric ward, 25 patients with sleep apnea syndrome were excluded, and 12 patients exhibiting RWA were identified. The clinical profiles were compared between the groups with and without RWA.The mean age and the frequency of neurocognitive disorders were significantly higher in 12 patients with RWA than in 18 without. Only five of the 12 patients exhibiting RWA had episodes of dream

2016 International Journal of Geriatric Psychiatry

138. Does Postural Rigidity Decrease during REM Sleep without Atonia in Parkinson Disease? Full Text available with Trip Pro

Does Postural Rigidity Decrease during REM Sleep without Atonia in Parkinson Disease? Rigidity is a muscle hypertonia typical of Parkinson disease (PD), whereas rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by abnormally increased muscle tone during REM sleep (REM sleep without atonia) and enacting dream behaviors. Because movements are not bradykinetic during RBD in patients with PD, we investigated whether the background, wake postural rigidity is attenuated during (...) REM sleep without atonia, in absence of movement.The amplitude of levator menti (postural muscle) electromyographic activity during relaxed evening wakefulness (considered as reference) and sleep (N2, N3, atonic REM sleep, and quiet REM sleep without atonia) was measured in 20 patients with PD (with and without RBD), 10 patients with idiopathic RBD patients and 10 healthy subjects.The chin tone amplitude progressively decreased from wake to N2, N3, and atonic REM sleep in the four groups

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

139. Conditioning of amitriptyline-induced REM sleep suppression in healthy participants: A randomized controlled trial. (Abstract)

Conditioning of amitriptyline-induced REM sleep suppression in healthy participants: A randomized controlled trial. Clinical trials in sleep disorders report substantial improvement in symptoms in their placebo groups. Behavioral conditioning is one of the underlying mechanisms of the placebo response. However, we do not know whether, and if so, the extent to which sleep architecture is influenced by behavioral conditioning, similarly to other physiological responses (i.e., those in the immune (...) system). We therefore applied a conditioning paradigm to 39 healthy adults pairing a novel-tasting drink (conditioned stimulus, CS) with the REM sleep suppressing tricyclic antidepressant amitriptyline as unconditioned stimulus during the acquisition phase. Subsequent sole presentation of the CS (together with a placebo pill) in an evocation night led to significantly more REM sleep in the amitriptyline group. Instead of the expected REM sleep suppression in the evocation night, we observed more REM

2016 Psychophysiology Controlled trial quality: uncertain

140. Alternatives to Clonazepam in REM Behavior Disorder Treatment Full Text available with Trip Pro

Alternatives to Clonazepam in REM Behavior Disorder Treatment 27397658 2018 08 17 2018 12 02 1550-9397 12 8 2016 08 15 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine J Clin Sleep Med Alternatives to Clonazepam in REM Behavior Disorder Treatment. 1193 10.5664/jcsm.6068 Escribá Jesús J Sleep Unit, Neurophysiology Department, Lluís Alcanyís Hospital, Xátiva, Valencia, Spain. Hoyo Blanca B Sleep Unit, Neurophysiology Department, Lluís (...) Alcanyís Hospital, Xátiva, Valencia, Spain. eng Letter Comment 2016 08 15 United States J Clin Sleep Med 101231977 1550-9389 5PE9FDE8GB Clonazepam JL5DK93RCL Melatonin IM J Clin Sleep Med. 2016 May 15;12(5):689-93 26857053 J Clin Sleep Med. 2016 Aug 15;12(8):1195-6 27448419 Clonazepam Humans Melatonin Polysomnography REM Sleep Behavior Disorder 2016 05 26 2016 06 02 2016 7 12 6 0 2016 7 12 6 0 2018 8 18 6 0 epublish 27397658 jc-00150-16 10.5664/jcsm.6068 PMC4957199 Sleep Med. 2013 Mar;14(3):237-42

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

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