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REM Sleep Behavior Disorder

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101. Parasomnia Overlap Disorder with Sexual Behaviors during Sleep in a Patient with Obstructive Sleep Apnea (PubMed)

, sleeptalking, and REM sleep behavior disorder (RBD). Confusional arousals and RBD were documented during the vPSG. This case had the added complexity of obstructive sleep apnea (OSA) playing a role in sleepwalking and sleep related eating, with good response to nasal continuous positive airway pressure (nCPAP). The sexsomnia did not respond to nCPAP but responded substantially to bedtime clonazepam therapy.© 2016 American Academy of Sleep Medicine. (...) Parasomnia Overlap Disorder with Sexual Behaviors during Sleep in a Patient with Obstructive Sleep Apnea Sleep-related abnormal sexual behaviors (sexsomnia) are classified as a subtype of NREM sleep parasomnias. Sexsomnia has been reported as part of parasomnia overlap disorder (POD) in two other patients. We present the case of a 42-year-old male patient with video-polysomnography (vPSG) documented POD. The patient had sleepwalking, sleep-related eating, confusional arousals, sexsomnia

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2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

102. Duloxetine-induced rapid eye movement sleep behavior disorder: a case report. (PubMed)

Duloxetine-induced rapid eye movement sleep behavior disorder: a case report. Tricyclic antidepressants and selective serotonin reuptake inhibitors have been reported to induce the symptoms of rapid eye movement (REM) sleep behavior disorder (RBD) or to exacerbate REM sleep without atonia. With this case report, we found an association between typical RBD and duloxetine, a serotonin-noradrenaline reuptake inhibitor.We present a case of a 62-year-old woman who experienced enactment behaviors (...) with violent dreams that were associated with increased tonic or phasic chin electromyography activity during REM sleep after treated with duloxetine. RBD symptoms were gradually reduced and completely ceased after discontinuation of duloxetine for 37 days.The current case appears to be the first observation of duloxetine-induced RBD. We describe features of RBD induced by duloxetine that are similar and different from that induced by tricyclic antidepressants and selective serotonin reuptake inhibitors.

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2017 BMC Psychiatry

103. Rapid Eye Movement Sleep Behavior Disorder: A Review of the Literature and Update on Current Concepts. (PubMed)

Rapid Eye Movement Sleep Behavior Disorder: A Review of the Literature and Update on Current Concepts. Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by abnormal behaviors emerging during REM sleep that may cause injury or sleep disruption. The diagnosis requires polysomnography (PSG) demonstrating a loss of normal skeletal muscle atonia during REM sleep. RBD results from dysfunction of the brain stem circuits responsible for maintaining normal REM sleep atonia (...) and suppressing behaviors during REM sleep. The diagnosis of idiopathic RBD (IRBD), that is, RBD without an identifiable cause, is frequently followed years later by the development of a neurodegenerative disorder, most commonly one of the synucleinopathies. As such, RBD is often a step in the progression of a neurodegenerative disorder. In this circumstance, it is a manifestation of neurodegeneration occurring in the brain stem before spreading to adjacent and other CNS regions, resulting in the development

2017 Chest

104. Clinical features of Parkinson’s disease with and without rapid eye movement sleep behavior disorder (PubMed)

, Shanghai General Hospital from January 2013 to August 2014. This study examined PD patients with or without RBD as determined by the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ), assessed motor subtype by Unified PD Rating Scale (UPDRS) III at "on" state, and compared the sub-scale scores representing tremor, rigidity, appendicular and axial. Investigators also assessed the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Mini-Mental State Examination (MMSE), Clinical (...) Clinical features of Parkinson’s disease with and without rapid eye movement sleep behavior disorder Rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease (PD) are two distinct clinical diseases but they share some common pathological and anatomical characteristics. This study aims to confirm the clinical features of RBD in Chinese PD patients.One hundred fifty PD patients were enrolled from the Parkinson`s disease and Movement Disorders Center in  Department of Neurology

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2017 Translational neurodegeneration

105. Transcriptome Analysis Reveals Altered Expression of Memory and Neurotransmission Associated Genes in the REM Sleep Deprived Rat Brain (PubMed)

Transcriptome Analysis Reveals Altered Expression of Memory and Neurotransmission Associated Genes in the REM Sleep Deprived Rat Brain Sleep disorders are associated with cognitive impairment. Selective rapid eye movement sleep (REMS) deprivation (REMSD) alters several physiological processes and behaviors. By employing NGS platform we carried out transcriptomic analysis in brain samples of control rats and those exposed to REMSD. The expression of genes involved in chromatin assembly (...) regulated. At least some of these changes are likely to regulate REMS and may participate in the consequences of REMS loss. Thus, the findings of this study have identified key epigenetic regulators and neuronal plasticity genes associated to REMS and its loss. This analysis provides a background and opens up avenues for unraveling their specific roles in the complex behavioral network particularly in relation to sustained REMS-loss associated changes.

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2017 Frontiers in molecular neuroscience

106. Sleep Disorder Management Diagnostic & Treatment Guidelines

terrors ? Rapid eye movement (REM) sleep behavior disorder ? Sleep-related epilepsy ? Sleep bruxism ? Sleep enuresis (bed wetting) ? Periodic limb movement disorder (PLMD) ? Nocturnal oxygen desaturation Polysomnography and Home Sleep TestingPolysomnography and Home Sleep Testing | Copyright © 2017. AIM Specialty Health. All Rights Reserved. 5 Overview Obstructive sleep apnea (OSA) is a common disorder affecting up to 2–4% of the population. Many patients with OSA remain undiagnosed. OSA (...) . Indications for In-Lab (Attended) Sleep Studies in Non-Adult Patients (Age 18 Years or Younger) Suspected sleep disorder (OSA or other) An in-lab sleep (attended) study is indicated if the patient meets any of the following criteria 1–11 below: 1. Habitual snoring in association with one or more of criteria a–e below: a. Restless or disturbed sleep b. Behavioral disturbance or learning disorders including deterioration in academic performance, attention deficit disorder, hyperactivity c. Frequent

2017 AIM Specialty Health

107. REM Sleep Behavior Disorder (Treatment)

REM Sleep Behavior Disorder (Treatment) REM Sleep Behavior Disorder Treatment & Management: Medical Care, Long-Term Monitoring Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODY1MS10cmVhdG1lbnQ= processing (...) > REM Sleep Behavior Disorder Treatment & Management Updated: Mar 11, 2019 Author: Syed M S Ahmed, MD; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections REM Sleep Behavior Disorder Treatment Medical Care The neurologist may consult a sleep specialist for the proper diagnosis and treatment of rapid eye movement sleep behavior disorder (RBD). RBD is treated symptomatically with various medications. However, the response varies in individual cases; therefore, all

2014 eMedicine.com

108. REM Sleep Behavior Disorder (Overview)

REM Sleep Behavior Disorder (Overview) REM Sleep Behavior Disorder: Background, Etiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODY1MS1vdmVydmlldw== processing > REM Sleep Behavior (...) Disorder Updated: Mar 11, 2019 Author: Syed M S Ahmed, MD; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections REM Sleep Behavior Disorder Overview Background Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disorder characterized by the loss of normal voluntary muscle atonia during REM sleep, in association with complex motor behavior while dreaming. [ , , , ] Diagnostic Criteria (DSM-5 and ICSD-2) The specific DSM-5 criteria for rapid eye movement

2014 eMedicine.com

109. REM Sleep Behavior Disorder (Follow-up)

REM Sleep Behavior Disorder (Follow-up) REM Sleep Behavior Disorder Treatment & Management: Medical Care, Long-Term Monitoring Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODY1MS10cmVhdG1lbnQ= processing (...) > REM Sleep Behavior Disorder Treatment & Management Updated: Mar 11, 2019 Author: Syed M S Ahmed, MD; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections REM Sleep Behavior Disorder Treatment Medical Care The neurologist may consult a sleep specialist for the proper diagnosis and treatment of rapid eye movement sleep behavior disorder (RBD). RBD is treated symptomatically with various medications. However, the response varies in individual cases; therefore, all

2014 eMedicine.com

110. REM Sleep Behavior Disorder (Diagnosis)

REM Sleep Behavior Disorder (Diagnosis) REM Sleep Behavior Disorder: Background, Etiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODY1MS1vdmVydmlldw== processing > REM Sleep Behavior (...) Disorder Updated: Mar 11, 2019 Author: Syed M S Ahmed, MD; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections REM Sleep Behavior Disorder Overview Background Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disorder characterized by the loss of normal voluntary muscle atonia during REM sleep, in association with complex motor behavior while dreaming. [ , , , ] Diagnostic Criteria (DSM-5 and ICSD-2) The specific DSM-5 criteria for rapid eye movement

2014 eMedicine.com

111. Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. (PubMed)

Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. To determine if sleep talkers with REM sleep behavior disorder (RBD) would utter during REM sleep sentences learned before sleep, and to evaluate their verbal memory consolidation during sleep.Eighteen patients with RBD and 10 controls performed two verbal memory tasks (16 words from the Free and Cued Selective Reminding Test and a 220-263 word long modified Story (...) consolidation was maintained in patients with RBD (+24±36% words) as in controls (+9±18%, p=0.3). The two demented patients with RBD also exhibited excellent nighttime consolidation. The post-sleep performance was unrelated to the sleep measures (including continuity, stages, fragmentation and apnea-hypopnea index). Daytime consolidation (-9±19%) was worse than night-time consolidation (+29±45%, p=0.03) in the subgroup of 9 patients with RBD. Eleven patients with RBD spoke during REM sleep and pronounced

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2013 PloS one

112. REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease. (PubMed)

REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease. Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by repeated episodes of dream enactment behavior and REM sleep without atonia (RSWA) during polysomnography recording. RSWA is characterized by increased phasic or tonic muscle activity seen on polysomnographic electromyogram channels. RSWA is a requisite diagnostic feature of RBD, but may (...) -synucleinopathy family of neurodegenerative disorders, which includes idiopathic Parkinson disease, Lewy body dementia, and multiple system atrophy. This review article considers the epidemiology of RBD, clinical and polysomnographic diagnostic standards for both RBD and RSWA, previously reported associations of RSWA and RBD with neurodegenerative disorders and other potential causes, the pathophysiology of which brain structures and networks mediate dysregulation of REM sleep muscle atonia

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2012 Current neurology and neuroscience reports

113. Mortality and Its Risk Factors in Patients with Rapid Eye Movement Sleep Behavior Disorder (PubMed)

Mortality and Its Risk Factors in Patients with Rapid Eye Movement Sleep Behavior Disorder To determine the mortality and its risk factors in patients with rapid eye movement (REM) sleep behavior disorder (RBD).A total of 205 consecutive patients with video-polysomnography confirmed RBD (mean age = 66.4 ± 10.0 y, 78.5% males) were recruited. Medical records and death status were systematically reviewed in the computerized records of the health care system. Standardized mortality ratio (SMR (...) was significantly associated with age (hazard ratio [HR] = 1.05; 95% CI, 1.01-1.10), living alone (HR = 2.04; 95% CI, 1.39-2.99), chronic obstructive pulmonary disease (HR = 3.38; 95% CI, 1.21-9.46), cancer (HR = 10.09; 95% CI, 2.65-38.42), periodic limb movements during sleep (HR = 3.06; 95% CI, 1.50-6.24), and development of neurodegenerative diseases (HR = 2.84; 95% CI, 1.47-5.45) and dementia (HR = 2.66; 95% CI, 1.39-5.08).Patients with RBD have a higher mortality rate than the general population only

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2016 Sleep

114. Rapid Eye Movement Sleep Behavior Disorder Symptoms Correlate with Domains of Cognitive Impairment in Parkinson's Disease (PubMed)

Rapid Eye Movement Sleep Behavior Disorder Symptoms Correlate with Domains of Cognitive Impairment in Parkinson's Disease Rapid eye movement (REM) sleep behavior disorder (RBD) may be a risk factor for cognitive impairment in patients with Parkinson's disease (PD). However, little is known regarding the relation between the severity of RBD and the different domains of cognitive impairment. The aim of this study was: (1) to investigate the domains of cognitive impairment in patients with PD

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2016 Chinese medical journal

115. Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development (PubMed)

Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by a history of recurrent nocturnal dream enactment behavior and loss of skeletal muscle atonia and increased phasic muscle activity during REM sleep: REM sleep without atonia. RBD and associated comorbidities have recently been identified as one of the most specific and potentially sensitive risk factors (...) for later development of any of the alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and other atypical parkinsonian syndromes. Several other sleep-related abnormalities have recently been identified in patients with RBD/Parkinson's disease who experience abnormalities in sleep electroencephalographic frequencies, sleep-wake transitions, wake and sleep stability, occurrence and morphology of sleep spindles, and electrooculography measures. These findings suggest a gradual

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2016 Nature and science of sleep

116. The Clinical Phenotype of Idiopathic Rapid Eye Movement Sleep Behavior Disorder at Presentation: A Study in 203 Consecutive Patients (PubMed)

The Clinical Phenotype of Idiopathic Rapid Eye Movement Sleep Behavior Disorder at Presentation: A Study in 203 Consecutive Patients To describe the clinical phenotype of idiopathic rapid eye movement (REM) sleep behavior disorder (IRBD) at presentation in a sleep center.Clinical history review of 203 consecutive patients with IRBD identified between 1990 and 2014. IRBD was diagnosed by clinical history plus video-polysomnographic demonstration of REM sleep with increased electromyographic (...) activity linked to abnormal behaviors.Patients were 80% men with median age at IRBD diagnosis of 68 y (range, 50-85 y). In addition to the already known clinical picture of IRBD, other important features were apparent: 44% of the patients were not aware of their dream-enactment behaviors and 70% reported good sleep quality. In most of these cases bed partners were essential to convince patients to seek medical help. In 11% IRBD was elicited only after specific questioning when patients consulted

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2016 Sleep

117. Structural Brain Alterations Associated with Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease (PubMed)

Structural Brain Alterations Associated with Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease Characterized by dream-enactment motor manifestations arising from rapid eye movement (REM) sleep, REM sleep behavior disorder (RBD) is frequently encountered in Parkinson's disease (PD). Yet the specific neurostructural changes associated with RBD in PD patients remain to be revealed by neuroimaging. Here we identified such neurostructural alterations by comparing large samples (...) and anterior cingulate cortex. These results demonstrate that RBD is associated with a prominent loss of volume in the pontomesencephalic tegmentum, where cholinergic, GABAergic and glutamatergic neurons are located and implicated in the promotion of REM sleep and muscle atonia. It is additionally associated with more widespread atrophy in other subcortical and cortical regions whose loss also likely contributes to the altered regulation of sleep-wake states and motor activity underlying RBD in PD patients.

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2016 Scientific reports

118. Comparison Study of Polysomnographic Features in Multiple System Atrophy-cerebellar Types Combined with and without Rapid Eye Movement Sleep Behavior Disorder (PubMed)

Comparison Study of Polysomnographic Features in Multiple System Atrophy-cerebellar Types Combined with and without Rapid Eye Movement Sleep Behavior Disorder The brain stem is found to be impaired in multiple system atrophy-cerebellar types (MSA-C). Rapid eye movement (REM) sleep behavior disorder (RBD) is reported as a marker of progressive brain stem dysfunction. Few systematic studies about the sleep disturbances in MSA-C patients combined with or without RBD were reported. This study aimed (...) to explore the polysomnographic (PSG) features of sleep disturbances between MSA-C patients with and without RBD.Totally, 46 MSA-C patients (23 with RBD, and 23 without RBD) were enrolled in this study. All patients underwent a structured interview for their demographic data, history of sleep pattern, and movement disorders; and then, overnight video-PSG was performed in each patient. All the records were evaluated by specialists at the Sleep Medicine Clinic for RBD and the Movement Disorder Clinic

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2016 Chinese medical journal

119. Wheel Running Improves REM Sleep and Attenuates Stress-induced Flattening of Diurnal Rhythms in F344 Rats (PubMed)

of sedentary or exercise conditions, rats were exposed to an acute stressor known to disrupt diurnal rhythms and produce behaviors associated with mood disorders. Prior to stressor exposure, exercise rats had higher CBT, more locomotor activity during the dark cycle, and greater %REM during the light cycle relative to sedentary rats. NREM and REM sleep were consolidated immediately following peak running to a greater extent in exercise, compared to sedentary rats. In response to stressor exposure, exercise (...) Wheel Running Improves REM Sleep and Attenuates Stress-induced Flattening of Diurnal Rhythms in F344 Rats Regular physical activity produces resistance to the negative health consequences of stressor exposure. One way that exercise may confer stress resistance is by reducing the impact of stress on diurnal rhythms and sleep; disruptions of which contribute to stress-related disease including mood disorders. Given the link between diurnal rhythm disruptions and stress-related disorders

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2016 Stress (Amsterdam, Netherlands)

120. REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. (PubMed)

REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. Rapid eye movement (REM) sleep behavior disorder (RBD) is commonly associated with Lewy body disease, narcolepsy, or depression. In contrast, the relationship between REM sleep without atonia (RWA), which is a hallmark of RBD on polysomnography, and clinical characteristics remains unclear. The purpose of this study is to investigate the clinical features of psychiatric patients (...) exhibiting RWA and its relevance to Lewy body disease.Of 55 consecutive patients who underwent polysomnography at the psychiatric ward, 25 patients with sleep apnea syndrome were excluded, and 12 patients exhibiting RWA were identified. The clinical profiles were compared between the groups with and without RWA.The mean age and the frequency of neurocognitive disorders were significantly higher in 12 patients with RWA than in 18 without. Only five of the 12 patients exhibiting RWA had episodes of dream

2016 International Journal of Geriatric Psychiatry

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