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REM Sleep Behavior Disorder

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101. Idiopathic REM sleep behavior disorder and neurodegenerative risk: To tell or not to tell to the patient? How to minimize the risk? (Abstract)

Idiopathic REM sleep behavior disorder and neurodegenerative risk: To tell or not to tell to the patient? How to minimize the risk? Most people with idiopathic REM sleep behavior disorder (iRBD) have an underlying synucleinopathy, mainly Parkinson's disease (PD) or dementia with Lewy bodies, with median conversion time of 4-9 y from iRBD diagnosis and of 11-16 y from symptom onset. Subtle signs and imaging tests indicate concomitant neurodegeneration in widespread brain areas. Risk factor (...) studies suggest that iRBD patients may have prior head injury, occupational farming, pesticide exposure, low education level and possibly more frequent family history of dream-enactment behavior (but not of PD), plus unexpected risk factors (smoking, ischemic heart disease and inhaled corticosteroid use). Unlike PD, caffeine and smoking appear not to have a protective role. Prior depression and antidepressant use may be early neurodegenerative signs rather than exclusively causative factors. Age

2016 Sleep medicine reviews

102. Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder

and other premotor symptoms of Lewy body disease. This study also collects gene extracts and sera to develop a biomarker for early detection of neurodegeneration. Condition or disease Intervention/treatment Phase Parkinson Disease REM Sleep Behavior Disorder Other: testing, evaluation, sampling Not Applicable Detailed Description: This study will include 3 groups in relation with RBD: idiopathic RBD (iRBD), PD- RBD, normal controls without RBD. In all groups, neurological examinations, olfactory (...) Professor, Seoul National University Hospital ClinicalTrials.gov Identifier: Other Study ID Numbers: 16-2013-101 First Posted: December 6, 2016 Last Update Posted: April 17, 2018 Last Verified: April 2018 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: Undecided Keywords provided by Jee-Young Lee, Seoul National University Hospital: Lewy body disease REM Sleep Behavior Disorder Parkinson disease Imaging Bio-markers Prospective cohort Additional relevant MeSH terms: Layout table

2016 Clinical Trials

103. Risk factors for probable REM sleep behavior disorder: A community-based study. Full Text available with Trip Pro

Risk factors for probable REM sleep behavior disorder: A community-based study. To examine risk factors for REM sleep behavior disorder (RBD) in a large-scale community-based study.This community-based study included 12,784 Chinese adults (10,556 men and 2,228 women, aged 24 years or older) who were free of Parkinson disease and dementia in 2012. Probable RBD (pRBD) status was determined by a validated questionnaire (Chinese RBD questionnaire-Hong Kong) in 2012. Potential risk factors-including (...) age, sex, smoking, socioeconomic status, physical activity, obesity, consumption of tea (surrogate for caffeine intake) and alcohol, serum concentrations of lipids and glucose, and chronic disease status-were assessed in 2006. Logistic regression was used to calculate odds ratios and 95% confidence intervals and to test differences in prevalence of pRBD across exposures.Prevalence of pRBD was 5.9% in men and 4.1% in women. In the fully adjusted model, risk factors that were significantly

2016 Neurology

104. Subtle gait and balance impairments occur in idiopathic rapid eye movement sleep behavior disorder. (Abstract)

Subtle gait and balance impairments occur in idiopathic rapid eye movement sleep behavior disorder. Although motor abnormalities have been flagged as potentially the most sensitive and specific clinical features for predicting the future progression to Parkinson's disease, little work has been done to characterize gait and balance impairments in idiopathic rapid eye movement sleep behavior disorder (iRBD).The objective of this study was to quantitatively determine any static balance as well (...) demonstrated greater step length asymmetry when compared with controls.This study demonstrates that iRBD patients have subtle gait impairments, which likely reflect early progressive degeneration in brainstem regions that regulate both REM sleep and gait coordination. Such gait assessments may be useful as a diagnostic preclinical screening tool for future fulminant gait abnormalities for trials of disease-preventive agents. © 2019 International Parkinson and Movement Disorder Society.© 2019 International

2019 Movement Disorders

105. EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke

is increasing in this group [1]. Stroke is a heterogeneous condition with a variety of underlying mechanisms and causes. The risk of stroke is a?ected by non-modi?able (e.g.age,familyhistory)andpotentiallymodi?ablefac- tors (e.g. hypertension, current smoking, alcohol con- sumption, obesity, diabetes, lack of physical activity, psychosocialstressanddepression)[2]. Sleep–wake disorders (SWDs) are very frequent in the general population and have a major impact on performance, quality of life as well (...) and a wide range of behavioural and clinical disorders that include fatigue, excessive daytime sleepiness, insomnia and non-restorative sleep, attention and cognitive de?- cits, and increased frequency of accidents, in addition to cardiovascular disorders, hypertension, diabetes mellitus and the metabolic syndrome, and depression [4,8,9]. Cluster analysis of large databases has demon- strated di?erent clinical phenotypes of OSA according to symptoms (sleepiness, insomnia, depression), anthropometric

2020 European Academy of Neurology

106. Sleep Disorder Management

disease 4. Central sleep apnea (defined as having at least 50% central events or more than 5 central events per hour) 5. Neuromuscular disorders (e.g., muscular dystrophy, myasthenia gravis) 6. Obesity hypoventilation syndrome defined as a body mass index (BMI) >30 kg/m 2 and hypoventilation which cannot be solely attributed to other conditions such as pulmonary disease, skeletal restriction, neuromuscular weakness, hypothyroidism, pleural pathology or medications. Documentation of hypoventilation (...) (sleepwalking) o Sleep terrors o Rapid eye movement (REM) sleep behavior disorder Sleep Disorder Management Copyright © 2020. AIM Specialty Health. All Rights Reserved. 7 o Sleep-related epilepsy o Sleep bruxism o Sleep enuresis (bed wetting) o Periodic limb movement disorder (PLMD) ? Nocturnal oxygen desaturation Overview Obstructive sleep apnea (OSA) is a common disorder affecting up to 2%–4% of the population. Many patients with OSA remain undiagnosed. OSA is characterized by repeated interruption

2020 AIM Specialty Health

107. Nocturnal REM Sleep Without Atonia Is a Diagnostic Biomarker of Pediatric Narcolepsy Full Text available with Trip Pro

Nocturnal REM Sleep Without Atonia Is a Diagnostic Biomarker of Pediatric Narcolepsy Compare nocturnal REM sleep without atonia (nRWA) and REM sleep behavior disorder (RBD) between pediatric patients with and without narcolepsy and determine if the nRWA index is a valid diagnostic biomarker for narcolepsy.Retrospective cohort study of children ages 6 to 18 years who completed a nocturnal polysomnogram (PSG) and Multiple Sleep Latency Test (MSLT). Our study sample included 11 patients (...) with narcolepsy type 1 (NT1), 6 with narcolepsy type 2 (NT2), 12 with idiopathic hypersomnia (IH), and 11 with subjective hypersomnia (sHS). We compared group nRWA indices (epochs of RWA/total stage R sleep epochs) from the nocturnal PSGs and analyzed nRWA index receiver operating curve (ROC) statistics for narcolepsy diagnosis.The median nRWA index of patients with NT1 was 15 to 30 times higher compared to sHS and IH (Ps < .005) but similar to that of the NT2 group (P = .46). RBD was present in 25

2018 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

108. A Particular Medullary-Spinal Inhibitory Pathway is Recruited for the Expression of Muscle Atonia During REM Sleep Full Text available with Trip Pro

A Particular Medullary-Spinal Inhibitory Pathway is Recruited for the Expression of Muscle Atonia During REM Sleep Muscle atonia is a major pathognomonic sign of paradoxical sleep (PS; coined REM Sleep), during which dreams mainly occur. In the 1980s, an idiopathic syndrome called REM sleep behavior disorder (RBD) was described in patients endowed with loss of PS paralysis concomitant to abnormal movements, suggesting a dysfunction of PS networks. Another major clinical RBD feature is its (...) prevalent phenoconversion into synucleinopathies as Parkinson's disease in a delay of 10-15 years after diagnosis. Thus, we undertook experiments in rats to disentangle brainstem networks involved in PS, including atonia. We first identified a contingent of pontine glutamate neurons recruited during PS with inputs to the ventromedial medulla (vmM) where they contact γ-aminobutyric acid (GABA)/glycine inhibitory neurons also activated during PS. Here, we further show that these vmM inhibitory neurons

2018 Journal of Experimental Neuroscience

109. Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies Full Text available with Trip Pro

Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by repeated episodes of REM sleep-related vocalizations and/or complex motor behaviors. Definite diagnosis of RBD is based on history and polysomnography, both of which are less accessible due to the lack of trained specialists and high (...) cost. While RBD may be associated with disorders like narcolepsy, focal brain lesions, and encephalitis, idiopathic RBD (iRBD) may convert to Parkinson's disease (PD) and other synucleinopathies in more than 80% of patients and it is to date the most specific clinical prodromal marker of PD. Identification of individuals at high risk for development of PD is becoming one of the most important topics for current PD-related research as well as for future treatment trials targeting prodromal PD

2018 Frontiers in neurology

110. Increased risk of impulse control symptoms in Parkinson's disease with REM sleep behaviour disorder. Full Text available with Trip Pro

Increased risk of impulse control symptoms in Parkinson's disease with REM sleep behaviour disorder. To assess the frequency of symptoms of impulse control disorders (ICD, namely pathological gambling, compulsive sexual behaviour, compulsive eating and compulsive shopping) and related behaviours (hobbyism, punding, walkabout and dopamine dysregulation syndrome) in patients with Parkinson's disease (PD) with and without probable rapid eye movement, sleep behaviour disorder (pRBD).Two hundred (...) and sixteen consecutive PD patients, attending two university-based movement disorders clinics, were screened for p-RBD using the RBD Single Question and the RBD Screening Questionnaire (RBDSQ). Current ICDs and related behaviours symptoms were assessed with the Questionnaire for Impulsive-Compulsive Disorders in PD (QUIP)-short form.PD-pRBD patients (n=106/216;49%) had a longer PD duration, a higher Hoehn & Yahr score, a greater levodopa-equivalent daily dose (LEDD), but no difference in dopamine agonist

2015 Neurosurgery and Psychiatry

111. Visual short-term memory deficits in REM sleep behaviour disorder mirror those in Parkinson's disease. Full Text available with Trip Pro

controls with no deficit observed in any of the control tasks. Importantly, the pattern of memory deficit in both patient groups was specifically explained by an increase in random responses. These results demonstrate that it is possible to detect the signature of memory impairment associated with Parkinson's disease in individuals with REM sleep behaviour disorder, a condition associated with a high risk of developing Parkinson's disease. The pattern of visual short-term memory deficit potentially (...) Visual short-term memory deficits in REM sleep behaviour disorder mirror those in Parkinson's disease. Individuals with REM sleep behaviour disorder are at significantly higher risk of developing Parkinson's disease. Here we examined visual short-term memory deficits--long associated with Parkinson's disease--in patients with REM sleep behaviour disorder without Parkinson's disease using a novel task that measures recall precision. Visual short-term memory for sequentially presented coloured

2015 Brain

112. Cardiac Sympathetic Activity differentiates Idiopathic and Symptomatic Rapid Eye Movement Sleep Behaviour Disorder Full Text available with Trip Pro

Cardiac Sympathetic Activity differentiates Idiopathic and Symptomatic Rapid Eye Movement Sleep Behaviour Disorder The pathophysiology of rapid eye movement sleep behavior disorder (RBD) associated with narcolepsy type 1 (NT1) is still poorly understood, potentially distinct from idiopathic RBD (iRBD), but may share affected common pathways. We investigated whether MIBG cardiac uptake differs between iRBD and NT1 comorbid with RBD. Thirty-four patients with NT1-RBD and 15 patients with iRBD (...) underwent MIBG cardiac scintigraphy. MIBG uptake was measured by calculating the early and delayed heart to mediastinum (H/M) ratios. A delayed H/M ratio lower than 1.46 was considered abnormal based on a population of 78 subjects without neurological or cardiac diseases. Patients with iRBD were older, had an older RBD onset age and higher REM sleep phasic and tonic muscular activities than NT1-RBD. Lower delayed and early H/M ratios were associated with iRBD, but not with NT1-RBD, in crude and adjusted

2018 Scientific reports

113. AIM Clinical Appropriateness Guidelines for Sleep Disorder Management

of OSA would allow avoidance of surgery; OR 8. Suspected congenital central alveolar hypoventilation syndrome or sleep-related hypoventilation due to neuromuscular disease or chest wall deformities; OR 9. Clinical evidence of a sleep-related breathing disorder in infants who have experienced an apparent life-threatening event; OR 10. For exclusion of OSA in a patient who has undergone adenotonsillectomy for suspected OSA more than eight (8) weeks previously; OR 11. The initial study was inadequate (...) terrors ? Rapid eye movement (REM) sleep behavior disorder ? Sleep-related epilepsy ? Sleep bruxism ? Sleep enuresis (bed wetting) ? Periodic limb movement disorder (PLMD) ? Nocturnal oxygen desaturation Polysomnography and Home Sleep TestingPolysomnography and Home Sleep Testing | Copyright © 2019. AIM Specialty Health. All Rights Reserved. 5 Overview Obstructive sleep apnea (OSA) is a common disorder affecting up to 2–4% of the population. Many patients with OSA remain undiagnosed. OSA

2019 AIM Specialty Health

114. Cellular and Molecular Mechanisms of REM Sleep Homeostatic Drive: A Plausible Component for Behavioral Plasticity Full Text available with Trip Pro

Cellular and Molecular Mechanisms of REM Sleep Homeostatic Drive: A Plausible Component for Behavioral Plasticity Homeostatic regulation of REM sleep drive, as measured by an increase in the number of REM sleep transitions, plays a key role in neuronal and behavioral plasticity (i.e., learning and memory). Deficits in REM sleep homeostatic drive (RSHD) are implicated in the development of many neuropsychiatric disorders. Yet, the cellular and molecular mechanisms underlying this RSHD remain (...) to be incomplete. To further our understanding of this mechanism, the current study was performed on freely moving rats to test a hypothesis that a positive interaction between extracellular-signal-regulated kinase 1 and 2 (ERK1/2) activity and brain-derived neurotrophic factor (BDNF) signaling in the pedunculopontine tegmentum (PPT) is a causal factor for the development of RSHD. Behavioral results of this study demonstrated that a short period (<90 min) of selective REM sleep restriction (RSR) exhibited

2017 Frontiers in neural circuits

115. Key sleep neurologic disorders: Narcolepsy, restless legs syndrome/Willis-Ekbom disease, and REM sleep behavior disorder Full Text available with Trip Pro

Key sleep neurologic disorders: Narcolepsy, restless legs syndrome/Willis-Ekbom disease, and REM sleep behavior disorder Sleep disorders are frequent comorbidities in neurologic patients. This review focuses on clinical aspects and prognosis of 3 neurologic sleep disorders: narcolepsy, restless legs syndrome/Willis-Ekbom disease (RLS/WED), and REM sleep behavior disorder (RBD). Narcolepsy causes pervasive, enduring excessive daytime sleepiness, adversely affecting patients' daily functioning (...) . RLS/WED is characterized by an uncomfortable urge to move the legs before sleep, often evolving toward augmentation and resulting in daylong bothersome symptoms. RBD causes potentially injurious dream enactment behaviors that often signify future evolution of overt synucleinopathy neurodegeneration in as many as 81% of patients. Timely recognition, referral for polysomnography, and longitudinal follow-up of narcolepsy, RLS/WED, and RBD patients are imperatives for neurologists in providing quality

2014 Neurology: Clinical Practice

116. REM sleep behavior disorder and neuropathology in Parkinson's disease. (Abstract)

REM sleep behavior disorder and neuropathology in Parkinson's disease. Rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with differences in clinical phenotype, including dementia, autonomic loss, and gait dysfunction. The pathological basis for this remains unclear.Parkinson's disease subjects in a longitudinal clinicopathologic study were screened for probable RBD with the Mayo Sleep Questionnaire. After death, semiquantitative analyses were (...) conducted for synuclein, amyloid, neurofibrillary tangles, and cerebrovascular lesions.Forty cases had probable RBD (PD+RBD), and 41 did not (PD-RBD). Despite similar age at death (∼80 y) and disease duration (∼14.5 y), PD+RBD had increased synuclein deposition in all regions examined, with nine of 10 regions significantly different. The Lewy body 10-region total score (scale = 0-40) was 29.5 in PD+RBD versus 24.5 in PD-RBD (Cohen-d effect size = 0.79, P = 0.002). Cerebrovascular lesion burden

2015 Movement Disorders

117. Parkinson disease with REM sleep behavior disorder: Features, α-synuclein, and inflammation. (Abstract)

Parkinson disease with REM sleep behavior disorder: Features, α-synuclein, and inflammation. To investigate clinical features and potential mechanisms involving α-synuclein oligomer and inflammation in patients with Parkinson disease (PD) and probable REM sleep behavior disorder (PRBD).We used the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) to evaluate patients with PD and classified each as PRBD or not probable (NPRBD). Data collection included demographic information (...) and evaluation of clinical symptoms using a series of rating scales. We tested for α-synuclein oligomer and inflammatory factors in CSF and serum. Data analyses included comparisons between PRBD and NPRBD groups and correlation analyses among RBDSQ score and levels of the above factors.The frequency of PRBD in patients with PD was 30.67%. The PRBD group had longer disease duration, more advanced disease stage, more severe motor symptoms, and other more severe nonmotor symptoms, including depression, anxiety

2015 Neurology

118. Sleep disturbances as risk factors for suicidal thoughts and behaviours: a meta-analysis of longitudinal studies Full Text available with Trip Pro

of insomnia: Associations with physical and mental health. J. Psychosom. Res. 67 , 109–116 (2009). 18. Taylor, D. J., Lichstein, K. L., Durrence, H. H., Reidel, B. W. & Bush, A. J. Epidemiology of insomnia, depression, and anxiety. Sleep 28 , 1457–1464 (2005). 19. Diagnostic and statistical manual of mental disorders: DSM-5 (American Psychiatric Association, 2013). 20. Morin, C. M., Colecchi, C., Stone, J., Sood, R. & Brink, D. Behavioral and pharmacological therapies for late-life insomnia: A randomized (...) , to ensure continued support, we are displaying the site without styles and JavaScript. article Sleep disturbances as risk factors for suicidal thoughts and behaviours: a meta-analysis of longitudinal studies Sleep disturbances as risk factors for suicidal thoughts and behaviours: a meta-analysis of longitudinal studies , , , & volume 10 , Article number: 13888 ( 2020 ) 1464 Accesses 1 Citations 18 Altmetric Subjects Abstract In recent years, there has been a growing interest in understanding

2020 Scientific reports

119. Progression of cognitive impairments in idiopathic REM sleep behaviour disorder. (Abstract)

Progression of cognitive impairments in idiopathic REM sleep behaviour disorder. Idiopathic REM (rapid eye movement) sleep behaviour disorder (iRBD) has been implicated in cognitive impairments, but there is little evidence about progression of cognitive dysfunction in iRBD.A retrospective follow-up study with patients with iRBD was performed. Conversion to neurodegenerative disorders was analysed by Kaplan-Meier survival analysis. Neuropsychological test results at baseline were compared (...) with disease duration or follow-up duration, and lower executive function at baseline increased conversion risk (p=0.031).Patients with iRBD have cognitive impairments at baseline and progressive cognitive decline over time. Even in idiopathic cases without development of any neurodegenerative disease, degenerative changes in cognition seem to be under way.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company

2015 Neurosurgery and Psychiatry

120. Age Effects on Cerebral Oxygenation and Behavior in Children with Sleep Disordered Breathing. (Abstract)

Age Effects on Cerebral Oxygenation and Behavior in Children with Sleep Disordered Breathing. Childhood sleep-disordered breathing ranges in severity from primary snoring to obstructive sleep apnea and is associated with behavioral and neurocognitive deficits. It remains unknown why children with primary snoring, who do not experience peripheral oxygen desaturation or sleep fragmentation, experience similar daytime deficits as those with obstructive sleep apnea or why effects are age (...) ), and moderate/severe obstructive sleep apnea (>5 events/h). Cognitive and behavioral performance were assessed.In the 3- to 6-year group, there were no differences in cerebral oxygenation or oxygen extraction between severity groups. In the 7- to 12-year group, cerebral oxygenation was significantly lower, although these differences were small, in control subjects versus primary snoring during quiet wakefulness before sleep onset, N1, and REM. Oxygen extraction was significantly higher in control subjects

2018 American Journal of Respiratory and Critical Care Medicine

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