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101. Sleep-disordered Breathing in Patients with COPD

. d We recommend that future research evaluate sleep-disordered breathing (i.e., central sleep apnea, OSA, increased upper airway resistance, hypoventilation, sleep fragmentation, etc.), rather than OSA speci?cally, in patients with COPD. d We recommend studies that seek to determine the pathophysiology of oxygen desaturation during REM sleep in patients with COPD. d We recommend trials that compare bilevel positive airway pressure to both continuous positive airway pressure and no positive airway (...) , 2’ EEG Right leg Left leg P-Snoring Snoring P-Flow Rib cage ECG O2 saturation (%) 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 93 93 93 93 93 93 93 Inspiratory Expiratory 10 Seconds Figure 4. Expiratory ?ow limitation and expiratory snoring in chronic obstructive pulmonary disease. A representative polysomnograph recording during non-REM sleep in a patient with sleep-disordered breathing and obstructive lung disease

2018 American Thoracic Society

102. Abnormal metabolic network activity in REM sleep behavior disorder. (PubMed)

Abnormal metabolic network activity in REM sleep behavior disorder. To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion.For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy

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2014 Neurology

103. Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke. (PubMed)

Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke. Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disturbance in which patients enact their dreams while in REM sleep. The behavior is typically violent in association with violent dream content, so serious harm can be done to the patient or the bed partner. The prevalence of RBD is well-known in Parkinson's disease, Lewy body dementia, and multiple systems atrophy. However, its prevalence (...) the severity of each stroke using the National Institute of Health Stroke Scale (NIHSS). One hundred and nineteen of the 775 patients meeting study entry criteria formed the study sample. All eligible participants were invited to attend a research clinic 3 months after the onset of the index stroke. In the attendance, a research assistant administered the MMSE and the 13-item RBD questionnaire (RBDQ).Among 119 stroke patients, 10.9% were exhibited RBD, defined as an REM sleep behavior disorder

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2014 BMC Neurology

104. Actigraphy as a diagnostic aid for REM sleep behavior disorder in Parkinson's disease. (PubMed)

Actigraphy as a diagnostic aid for REM sleep behavior disorder in Parkinson's disease. Rapid eye movement (REM) sleep behavior disorder (RBD) is a common parasomnia in Parkinson's disease (PD) patients. The current International Classification of Sleep Disorders (ICSD-II) requires a clinical interview combined with video polysomnography (video-PSG) to diagnose. The latter is time consuming and expensive and not always feasible in clinical practice. Here we studied the use of actigraphy

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2014 BMC Neurology

105. Five-year follow-up of substantia nigra echogenicity in idiopathic REM sleep behavior disorder. (PubMed)

Five-year follow-up of substantia nigra echogenicity in idiopathic REM sleep behavior disorder. Hyperechogenicity of the substantia nigra visualized by transcranial sonography occurs in most Parkinson's disease (PD) patients. Idiopathic rapid eye movement (REM) sleep behavior disorder (IRBD) subjects eventually develop PD and other synucleinopathies. This study was undertaken to evaluate whether in IRBD, transcranial sonography identifies subjects who convert to PD and other synucleinopathies (...)  = 0.125). Transcranial sonography of the substantia nigra alone is not a useful tool to identify IRBD subjects at risk for the development of PD or a synucleinopathy after 5 years of follow-up. In IRBD, transcranial sonography cannot be used to monitor the degenerative process in the substantia nigra, because echogenicity size remains stable over time.© 2014 International Parkinson and Movement Disorder Society.

2014 Movement Disorders

106. Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism

Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02312908 Recruitment Status : Completed First Posted : December 9, 2014 Last Update Posted : April 25, 2016 Sponsor: Seoul National University Hospital Collaborator

2014 Clinical Trials

107. Parasomnia Overlap Disorder with Sexual Behaviors during Sleep in a Patient with Obstructive Sleep Apnea (PubMed)

, sleeptalking, and REM sleep behavior disorder (RBD). Confusional arousals and RBD were documented during the vPSG. This case had the added complexity of obstructive sleep apnea (OSA) playing a role in sleepwalking and sleep related eating, with good response to nasal continuous positive airway pressure (nCPAP). The sexsomnia did not respond to nCPAP but responded substantially to bedtime clonazepam therapy.© 2016 American Academy of Sleep Medicine. (...) Parasomnia Overlap Disorder with Sexual Behaviors during Sleep in a Patient with Obstructive Sleep Apnea Sleep-related abnormal sexual behaviors (sexsomnia) are classified as a subtype of NREM sleep parasomnias. Sexsomnia has been reported as part of parasomnia overlap disorder (POD) in two other patients. We present the case of a 42-year-old male patient with video-polysomnography (vPSG) documented POD. The patient had sleepwalking, sleep-related eating, confusional arousals, sexsomnia

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2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

108. Transcriptome Analysis Reveals Altered Expression of Memory and Neurotransmission Associated Genes in the REM Sleep Deprived Rat Brain (PubMed)

Transcriptome Analysis Reveals Altered Expression of Memory and Neurotransmission Associated Genes in the REM Sleep Deprived Rat Brain Sleep disorders are associated with cognitive impairment. Selective rapid eye movement sleep (REMS) deprivation (REMSD) alters several physiological processes and behaviors. By employing NGS platform we carried out transcriptomic analysis in brain samples of control rats and those exposed to REMSD. The expression of genes involved in chromatin assembly (...) regulated. At least some of these changes are likely to regulate REMS and may participate in the consequences of REMS loss. Thus, the findings of this study have identified key epigenetic regulators and neuronal plasticity genes associated to REMS and its loss. This analysis provides a background and opens up avenues for unraveling their specific roles in the complex behavioral network particularly in relation to sustained REMS-loss associated changes.

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2017 Frontiers in molecular neuroscience

109. Duloxetine-induced rapid eye movement sleep behavior disorder: a case report. (PubMed)

Duloxetine-induced rapid eye movement sleep behavior disorder: a case report. Tricyclic antidepressants and selective serotonin reuptake inhibitors have been reported to induce the symptoms of rapid eye movement (REM) sleep behavior disorder (RBD) or to exacerbate REM sleep without atonia. With this case report, we found an association between typical RBD and duloxetine, a serotonin-noradrenaline reuptake inhibitor.We present a case of a 62-year-old woman who experienced enactment behaviors (...) with violent dreams that were associated with increased tonic or phasic chin electromyography activity during REM sleep after treated with duloxetine. RBD symptoms were gradually reduced and completely ceased after discontinuation of duloxetine for 37 days.The current case appears to be the first observation of duloxetine-induced RBD. We describe features of RBD induced by duloxetine that are similar and different from that induced by tricyclic antidepressants and selective serotonin reuptake inhibitors.

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2017 BMC Psychiatry

110. Rapid Eye Movement Sleep Behavior Disorder: A Review of the Literature and Update on Current Concepts. (PubMed)

Rapid Eye Movement Sleep Behavior Disorder: A Review of the Literature and Update on Current Concepts. Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by abnormal behaviors emerging during REM sleep that may cause injury or sleep disruption. The diagnosis requires polysomnography (PSG) demonstrating a loss of normal skeletal muscle atonia during REM sleep. RBD results from dysfunction of the brain stem circuits responsible for maintaining normal REM sleep atonia (...) and suppressing behaviors during REM sleep. The diagnosis of idiopathic RBD (IRBD), that is, RBD without an identifiable cause, is frequently followed years later by the development of a neurodegenerative disorder, most commonly one of the synucleinopathies. As such, RBD is often a step in the progression of a neurodegenerative disorder. In this circumstance, it is a manifestation of neurodegeneration occurring in the brain stem before spreading to adjacent and other CNS regions, resulting in the development

2017 Chest

111. Clinical features of Parkinson’s disease with and without rapid eye movement sleep behavior disorder (PubMed)

, Shanghai General Hospital from January 2013 to August 2014. This study examined PD patients with or without RBD as determined by the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ), assessed motor subtype by Unified PD Rating Scale (UPDRS) III at "on" state, and compared the sub-scale scores representing tremor, rigidity, appendicular and axial. Investigators also assessed the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Mini-Mental State Examination (MMSE), Clinical (...) Clinical features of Parkinson’s disease with and without rapid eye movement sleep behavior disorder Rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease (PD) are two distinct clinical diseases but they share some common pathological and anatomical characteristics. This study aims to confirm the clinical features of RBD in Chinese PD patients.One hundred fifty PD patients were enrolled from the Parkinson`s disease and Movement Disorders Center in  Department of Neurology

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2017 Translational neurodegeneration

112. Sleep Disorder Management Diagnostic & Treatment Guidelines

terrors ? Rapid eye movement (REM) sleep behavior disorder ? Sleep-related epilepsy ? Sleep bruxism ? Sleep enuresis (bed wetting) ? Periodic limb movement disorder (PLMD) ? Nocturnal oxygen desaturation Polysomnography and Home Sleep TestingPolysomnography and Home Sleep Testing | Copyright © 2017. AIM Specialty Health. All Rights Reserved. 5 Overview Obstructive sleep apnea (OSA) is a common disorder affecting up to 2–4% of the population. Many patients with OSA remain undiagnosed. OSA (...) . Indications for In-Lab (Attended) Sleep Studies in Non-Adult Patients (Age 18 Years or Younger) Suspected sleep disorder (OSA or other) An in-lab sleep (attended) study is indicated if the patient meets any of the following criteria 1–11 below: 1. Habitual snoring in association with one or more of criteria a–e below: a. Restless or disturbed sleep b. Behavioral disturbance or learning disorders including deterioration in academic performance, attention deficit disorder, hyperactivity c. Frequent

2017 AIM Specialty Health

113. REM Sleep Behavior Disorder (Treatment)

REM Sleep Behavior Disorder (Treatment) REM Sleep Behavior Disorder Treatment & Management: Medical Care, Long-Term Monitoring Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODY1MS10cmVhdG1lbnQ= processing (...) > REM Sleep Behavior Disorder Treatment & Management Updated: Mar 11, 2019 Author: Syed M S Ahmed, MD; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections REM Sleep Behavior Disorder Treatment Medical Care The neurologist may consult a sleep specialist for the proper diagnosis and treatment of rapid eye movement sleep behavior disorder (RBD). RBD is treated symptomatically with various medications. However, the response varies in individual cases; therefore, all

2014 eMedicine.com

114. REM Sleep Behavior Disorder (Overview)

REM Sleep Behavior Disorder (Overview) REM Sleep Behavior Disorder: Background, Etiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODY1MS1vdmVydmlldw== processing > REM Sleep Behavior (...) Disorder Updated: Mar 11, 2019 Author: Syed M S Ahmed, MD; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections REM Sleep Behavior Disorder Overview Background Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disorder characterized by the loss of normal voluntary muscle atonia during REM sleep, in association with complex motor behavior while dreaming. [ , , , ] Diagnostic Criteria (DSM-5 and ICSD-2) The specific DSM-5 criteria for rapid eye movement

2014 eMedicine.com

115. REM Sleep Behavior Disorder (Follow-up)

REM Sleep Behavior Disorder (Follow-up) REM Sleep Behavior Disorder Treatment & Management: Medical Care, Long-Term Monitoring Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODY1MS10cmVhdG1lbnQ= processing (...) > REM Sleep Behavior Disorder Treatment & Management Updated: Mar 11, 2019 Author: Syed M S Ahmed, MD; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections REM Sleep Behavior Disorder Treatment Medical Care The neurologist may consult a sleep specialist for the proper diagnosis and treatment of rapid eye movement sleep behavior disorder (RBD). RBD is treated symptomatically with various medications. However, the response varies in individual cases; therefore, all

2014 eMedicine.com

116. REM Sleep Behavior Disorder (Diagnosis)

REM Sleep Behavior Disorder (Diagnosis) REM Sleep Behavior Disorder: Background, Etiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODY1MS1vdmVydmlldw== processing > REM Sleep Behavior (...) Disorder Updated: Mar 11, 2019 Author: Syed M S Ahmed, MD; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections REM Sleep Behavior Disorder Overview Background Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disorder characterized by the loss of normal voluntary muscle atonia during REM sleep, in association with complex motor behavior while dreaming. [ , , , ] Diagnostic Criteria (DSM-5 and ICSD-2) The specific DSM-5 criteria for rapid eye movement

2014 eMedicine.com

117. Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. (PubMed)

Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. To determine if sleep talkers with REM sleep behavior disorder (RBD) would utter during REM sleep sentences learned before sleep, and to evaluate their verbal memory consolidation during sleep.Eighteen patients with RBD and 10 controls performed two verbal memory tasks (16 words from the Free and Cued Selective Reminding Test and a 220-263 word long modified Story (...) consolidation was maintained in patients with RBD (+24±36% words) as in controls (+9±18%, p=0.3). The two demented patients with RBD also exhibited excellent nighttime consolidation. The post-sleep performance was unrelated to the sleep measures (including continuity, stages, fragmentation and apnea-hypopnea index). Daytime consolidation (-9±19%) was worse than night-time consolidation (+29±45%, p=0.03) in the subgroup of 9 patients with RBD. Eleven patients with RBD spoke during REM sleep and pronounced

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2013 PloS one Controlled trial quality: uncertain

118. REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease. (PubMed)

REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease. Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by repeated episodes of dream enactment behavior and REM sleep without atonia (RSWA) during polysomnography recording. RSWA is characterized by increased phasic or tonic muscle activity seen on polysomnographic electromyogram channels. RSWA is a requisite diagnostic feature of RBD, but may (...) -synucleinopathy family of neurodegenerative disorders, which includes idiopathic Parkinson disease, Lewy body dementia, and multiple system atrophy. This review article considers the epidemiology of RBD, clinical and polysomnographic diagnostic standards for both RBD and RSWA, previously reported associations of RSWA and RBD with neurodegenerative disorders and other potential causes, the pathophysiology of which brain structures and networks mediate dysregulation of REM sleep muscle atonia

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2012 Current neurology and neuroscience reports

119. Wheel Running Improves REM Sleep and Attenuates Stress-induced Flattening of Diurnal Rhythms in F344 Rats (PubMed)

of sedentary or exercise conditions, rats were exposed to an acute stressor known to disrupt diurnal rhythms and produce behaviors associated with mood disorders. Prior to stressor exposure, exercise rats had higher CBT, more locomotor activity during the dark cycle, and greater %REM during the light cycle relative to sedentary rats. NREM and REM sleep were consolidated immediately following peak running to a greater extent in exercise, compared to sedentary rats. In response to stressor exposure, exercise (...) Wheel Running Improves REM Sleep and Attenuates Stress-induced Flattening of Diurnal Rhythms in F344 Rats Regular physical activity produces resistance to the negative health consequences of stressor exposure. One way that exercise may confer stress resistance is by reducing the impact of stress on diurnal rhythms and sleep; disruptions of which contribute to stress-related disease including mood disorders. Given the link between diurnal rhythm disruptions and stress-related disorders

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2016 Stress (Amsterdam, Netherlands)

120. REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. (PubMed)

REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. Rapid eye movement (REM) sleep behavior disorder (RBD) is commonly associated with Lewy body disease, narcolepsy, or depression. In contrast, the relationship between REM sleep without atonia (RWA), which is a hallmark of RBD on polysomnography, and clinical characteristics remains unclear. The purpose of this study is to investigate the clinical features of psychiatric patients (...) exhibiting RWA and its relevance to Lewy body disease.Of 55 consecutive patients who underwent polysomnography at the psychiatric ward, 25 patients with sleep apnea syndrome were excluded, and 12 patients exhibiting RWA were identified. The clinical profiles were compared between the groups with and without RWA.The mean age and the frequency of neurocognitive disorders were significantly higher in 12 patients with RWA than in 18 without. Only five of the 12 patients exhibiting RWA had episodes of dream

2016 International Journal of Geriatric Psychiatry

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