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REM Sleep Behavior Disorder

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81. Best Practice Guide for the Treatment of REM Sleep Behavior Disorder (RBD)

Best Practice Guide for the Treatment of REM Sleep Behavior Disorder (RBD) R. Nisha Aurora" /> JCSM - Best Practice Guide for the Treatment of REM Sleep Behavior Disorder (RBD) Search article archive here ADVERTISEMENT Current Issue: Volume: 15 Number: 03 Issue Navigator Volume 06 No. 01 .9-10 Charles F. Reynolds III, M.D. 1 ; Susan Redline, M.D. 2 ; for the DSM-V Sleep-Wake Disorders Workgroup and Advisors* .11-17 Nathaniel F. Watson, M.D., M.S. 1 ; Dedra Buchwald, M.D. 2 ; Michael V. Vitiello (...) , of the article without the written permission of the AASM. Further, purchase does not permit the posting of article text on an online forum or website. E-mail Share Slides Please login to download PDF Subscribers can download and print full articles from current and past issues of the JCSM Not a subscriber? and receive a subscription to JCSM with your membership Special Articles Best Practice Guide for the Treatment of REM Sleep Behavior Disorder (RBD) Standards of Practice Committee: R. Nisha Aurora, M.D. 1

2010 American Academy of Sleep Medicine

82. Age Effects on Cerebral Oxygenation and Behavior in Children with Sleep Disordered Breathing. (PubMed)

Age Effects on Cerebral Oxygenation and Behavior in Children with Sleep Disordered Breathing. Childhood sleep-disordered breathing ranges in severity from primary snoring to obstructive sleep apnea and is associated with behavioral and neurocognitive deficits. It remains unknown why children with primary snoring, who do not experience peripheral oxygen desaturation or sleep fragmentation, experience similar daytime deficits as those with obstructive sleep apnea or why effects are age (...) ), and moderate/severe obstructive sleep apnea (>5 events/h). Cognitive and behavioral performance were assessed.In the 3- to 6-year group, there were no differences in cerebral oxygenation or oxygen extraction between severity groups. In the 7- to 12-year group, cerebral oxygenation was significantly lower, although these differences were small, in control subjects versus primary snoring during quiet wakefulness before sleep onset, N1, and REM. Oxygen extraction was significantly higher in control subjects

2018 American Journal of Respiratory and Critical Care Medicine

83. Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies (PubMed)

Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by repeated episodes of REM sleep-related vocalizations and/or complex motor behaviors. Definite diagnosis of RBD is based on history and polysomnography, both of which are less accessible due to the lack of trained specialists and high (...) cost. While RBD may be associated with disorders like narcolepsy, focal brain lesions, and encephalitis, idiopathic RBD (iRBD) may convert to Parkinson's disease (PD) and other synucleinopathies in more than 80% of patients and it is to date the most specific clinical prodromal marker of PD. Identification of individuals at high risk for development of PD is becoming one of the most important topics for current PD-related research as well as for future treatment trials targeting prodromal PD

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2018 Frontiers in neurology

84. A Particular Medullary-Spinal Inhibitory Pathway is Recruited for the Expression of Muscle Atonia During REM Sleep (PubMed)

A Particular Medullary-Spinal Inhibitory Pathway is Recruited for the Expression of Muscle Atonia During REM Sleep Muscle atonia is a major pathognomonic sign of paradoxical sleep (PS; coined REM Sleep), during which dreams mainly occur. In the 1980s, an idiopathic syndrome called REM sleep behavior disorder (RBD) was described in patients endowed with loss of PS paralysis concomitant to abnormal movements, suggesting a dysfunction of PS networks. Another major clinical RBD feature is its

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2018 Journal of Experimental Neuroscience

85. Nocturnal REM Sleep Without Atonia Is a Diagnostic Biomarker of Pediatric Narcolepsy (PubMed)

Nocturnal REM Sleep Without Atonia Is a Diagnostic Biomarker of Pediatric Narcolepsy Compare nocturnal REM sleep without atonia (nRWA) and REM sleep behavior disorder (RBD) between pediatric patients with and without narcolepsy and determine if the nRWA index is a valid diagnostic biomarker for narcolepsy.Retrospective cohort study of children ages 6 to 18 years who completed a nocturnal polysomnogram (PSG) and Multiple Sleep Latency Test (MSLT). Our study sample included 11 patients (...) with narcolepsy type 1 (NT1), 6 with narcolepsy type 2 (NT2), 12 with idiopathic hypersomnia (IH), and 11 with subjective hypersomnia (sHS). We compared group nRWA indices (epochs of RWA/total stage R sleep epochs) from the nocturnal PSGs and analyzed nRWA index receiver operating curve (ROC) statistics for narcolepsy diagnosis.The median nRWA index of patients with NT1 was 15 to 30 times higher compared to sHS and IH (Ps < .005) but similar to that of the NT2 group (P = .46). RBD was present in 25

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2018 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

86. Gait and REM Sleep Behavior Disorder

Gait and REM Sleep Behavior Disorder Gait and REM Sleep Behavior Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Gait and REM Sleep Behavior Disorder (RBD-M2H) The safety and scientific validity (...) Information provided by (Responsible Party): University Hospital, Montpellier Study Details Study Description Go to Brief Summary: Many people with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) have an underlying synucleinopathy, the most common of which are Parkinson's disease (PD) and Lewy body disease. Identifying additional abnormal clinical features may help in identifying those at greater risk of evolving to a more severe syndrome. Because gait disorders are common

2015 Clinical Trials

87. A new view of "dream enactment" in REM sleep behavior disorder. (PubMed)

A new view of "dream enactment" in REM sleep behavior disorder. Patients with REM sleep behavior disorder (RBD) exhibit increased muscle tone and exaggerated myoclonic twitching during REM sleep. In addition, violent movements of the limbs, and complex behaviors that can sometimes appear to involve the enactment of dreams, are associated with RBD. These behaviors are widely thought to result from a dysfunction involving atonia-producing neural circuitry in the brainstem, thereby unmasking (...) cortically generated dreams. Here we scrutinize the assumptions that led to this interpretation of RBD. In particular, we challenge the assumption that motor cortex produces twitches during REM sleep, thus calling into question the related assumption that motor cortex is primarily responsible for all of the pathological movements of RBD. Moreover, motor cortex is not even necessary to produce complex behavior; for example, stimulation of some brainstem structures can produce defensive and aggressive

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2015 Sleep medicine reviews

88. REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers. (PubMed)

REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers. Rapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2-PD and utility as a preclinical marker has not been established.One hundred forty-four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non-manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior (...) in LRRK2-PD, especially in early LRRK2-PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD.© 2015 International Parkinson and Movement Disorder Society.

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2015 Movement Disorders

89. REM sleep behavior disorder and neuropathology in Parkinson's disease. (PubMed)

REM sleep behavior disorder and neuropathology in Parkinson's disease. Rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with differences in clinical phenotype, including dementia, autonomic loss, and gait dysfunction. The pathological basis for this remains unclear.Parkinson's disease subjects in a longitudinal clinicopathologic study were screened for probable RBD with the Mayo Sleep Questionnaire. After death, semiquantitative analyses were (...) was slightly higher in PD-RBD.Although overlap occurs between groups, PD patients with probable RBD may have greater density and range of synuclein pathology on autopsy.© 2015 International Parkinson and Movement Disorder Society.

2015 Movement Disorders

90. Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder. (PubMed)

Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder. To investigate the expression of α-synuclein in colonic biopsies of patients with idiopathic REM sleep behavior disorder (iRBD) and address if α-synuclein immunostaining of tissue obtained via colonic biopsies holds promise as a diagnostic biomarker for prodromal Parkinson disease (PD).Patients with iRBD, patients with PD, and healthy controls were prospectively recruited to undergo colonic biopsies

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2015 Neurology

91. Nigro-caudate dopaminergic deafferentation: a marker of REM sleep behavior disorder? (PubMed)

Nigro-caudate dopaminergic deafferentation: a marker of REM sleep behavior disorder? Forty-nine consecutive, drug naïve outpatients with de novo Parkinson's disease (PD) and 12 patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) underwent clinical examination and dopamine transporter single photon emission computed tomography with [(123)I]-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane as a biomarker of nigro-striatal function. PD patients were grouped (...) into rapid eye movement sleep behavior disorder (RBD) negative (PD-RBD-) and RBD positive (PD-RBD+). Repeated measures and univariate analysis of variance were used to compare dopaminergic and clinical impairment among groups. The variations of dopamine transporter-single photon emission computed tomography specific binding ratios (SBR) as a function of group belonging were significantly different (p = 0.0013) at caudate with respect to putamen level. Indeed, putamen SBR progressively decreased from iRBD

2015 Neurobiology of Aging

92. Management of REM sleep behavior disorder: An evidence based review (PubMed)

Management of REM sleep behavior disorder: An evidence based review Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by dream enactment behavior resulting from a loss of REM skeletal muscle atonia. The neurobiology of REM sleep and the characteristic features of REM atonia have an important basis for understanding the aggravating etiologies the proposed pharmacological interventions in its management. This review outlines the evidence for behavioral and therapeutic

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2015 Annals of Indian Academy of Neurology

93. Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis. (PubMed)

Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis. Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia frequently affecting patients with synucleinopathies, but its exact prevalence in multiple system atrophy (MSA) is unclear. Whether questionnaires alone are sufficient to diagnose RBD is also unknown.We performed a cross-sectional study of patients with probable MSA from six academic centers in the US and Europe. RBD

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2015 Clinical autonomic research : official journal of the Clinical Autonomic Research Society

94. Parkinson disease with REM sleep behavior disorder: Features, α-synuclein, and inflammation. (PubMed)

Parkinson disease with REM sleep behavior disorder: Features, α-synuclein, and inflammation. To investigate clinical features and potential mechanisms involving α-synuclein oligomer and inflammation in patients with Parkinson disease (PD) and probable REM sleep behavior disorder (PRBD).We used the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) to evaluate patients with PD and classified each as PRBD or not probable (NPRBD). Data collection included demographic information

2015 Neurology

95. Reduced striatal dopamine transmission in REM sleep behavior disorder comorbid with depression. (PubMed)

Reduced striatal dopamine transmission in REM sleep behavior disorder comorbid with depression. To investigate dopamine transmission in patients with comorbid REM sleep behavior disorder (RBD) and major depressive disorder (MDD).This is a case-control study including 11 medicated patients with comorbid RBD and MDD (mean age 47.5 ± 8.2), 8 medicated patients with MDD only (mean age 47.9 ± 8.4), and 10 healthy participants (mean age 46.5 ± 10.6 years). They underwent clinical assessment, video (...) < 0.01) and REM-related tonic muscle activity (p < 0.01). The comorbid RBD and MDD group had more impairment in olfactory function.Patients with comorbid RBD and MDD had presynaptic dopamine dysfunction and impaired olfactory function. There is a distinct possibility that the development of RBD symptoms among patients with MDD may represent an early phase of α-synucleinopathy neurodegeneration instead of a merely antidepressant-induced condition.© 2015 American Academy of Neurology.

2015 Neurology

96. Sleep-disordered Breathing in Patients with COPD

. d We recommend that future research evaluate sleep-disordered breathing (i.e., central sleep apnea, OSA, increased upper airway resistance, hypoventilation, sleep fragmentation, etc.), rather than OSA speci?cally, in patients with COPD. d We recommend studies that seek to determine the pathophysiology of oxygen desaturation during REM sleep in patients with COPD. d We recommend trials that compare bilevel positive airway pressure to both continuous positive airway pressure and no positive airway (...) , 2’ EEG Right leg Left leg P-Snoring Snoring P-Flow Rib cage ECG O2 saturation (%) 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 94 93 93 93 93 93 93 93 Inspiratory Expiratory 10 Seconds Figure 4. Expiratory ?ow limitation and expiratory snoring in chronic obstructive pulmonary disease. A representative polysomnograph recording during non-REM sleep in a patient with sleep-disordered breathing and obstructive lung disease

2018 American Thoracic Society

97. Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism

Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02312908 Recruitment Status : Completed First Posted : December 9, 2014 Last Update Posted : April 25, 2016 Sponsor: Seoul National University Hospital Collaborator

2014 Clinical Trials

98. Abnormal metabolic network activity in REM sleep behavior disorder. (PubMed)

Abnormal metabolic network activity in REM sleep behavior disorder. To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion.For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy

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2014 Neurology

99. Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke. (PubMed)

Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke. Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disturbance in which patients enact their dreams while in REM sleep. The behavior is typically violent in association with violent dream content, so serious harm can be done to the patient or the bed partner. The prevalence of RBD is well-known in Parkinson's disease, Lewy body dementia, and multiple systems atrophy. However, its prevalence (...) the severity of each stroke using the National Institute of Health Stroke Scale (NIHSS). One hundred and nineteen of the 775 patients meeting study entry criteria formed the study sample. All eligible participants were invited to attend a research clinic 3 months after the onset of the index stroke. In the attendance, a research assistant administered the MMSE and the 13-item RBD questionnaire (RBDQ).Among 119 stroke patients, 10.9% were exhibited RBD, defined as an REM sleep behavior disorder

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2014 BMC Neurology

100. Actigraphy as a diagnostic aid for REM sleep behavior disorder in Parkinson's disease. (PubMed)

Actigraphy as a diagnostic aid for REM sleep behavior disorder in Parkinson's disease. Rapid eye movement (REM) sleep behavior disorder (RBD) is a common parasomnia in Parkinson's disease (PD) patients. The current International Classification of Sleep Disorders (ICSD-II) requires a clinical interview combined with video polysomnography (video-PSG) to diagnose. The latter is time consuming and expensive and not always feasible in clinical practice. Here we studied the use of actigraphy

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2014 BMC Neurology

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