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REM Sleep Behavior Disorder

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81. Longitudinal changes in cognition in early Parkinson’s disease patients with REM sleep behavior disorder Full Text available with Trip Pro

Longitudinal changes in cognition in early Parkinson’s disease patients with REM sleep behavior disorder Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains.Parkinson's Progression Markers Initiative (PPMI) is a multi-site, international study of PD (...) patients untreated at enrollment. pRBD was assessed with the REM sleep behavior disorder questionnaire (RBDSQ). Global cognition was assessed at baseline and annually using the Montreal Cognitive Assessment (MoCA) and a cognitive battery. Linear mixed effects models were used to examine the relationship between pRBD (RBDSQ≥6) and rate of change in cognitive variables. Age, sex, years of education, and baseline motor and cognitive scores were included as covariates.The baseline sample consisted of 423

2016 Parkinsonism & related disorders

82. Brain Atrophy of Secondary REM-Sleep Behavior Disorder in Neurodegenerative Disease Full Text available with Trip Pro

Brain Atrophy of Secondary REM-Sleep Behavior Disorder in Neurodegenerative Disease Rapid eye movement sleep behavior disorder (RBD) may present as an early manifestation of an evolving neurodegenerative disorder with alpha-synucleinopathy.We investigated that dementia with RBD might show distinctive cortical atrophic patterns.A total of 31 patients with idiopathic Parkinson's disease (IPD), 23 with clinically probable Alzheimer's disease (AD), and 36 healthy controls participated in this study (...) diseases and RBD showed distinctive brain atrophy patterns, especially in the posterior and inferior cortices. These results suggest that patients diagnosed with clinically probable AD or IPD might have mixed pathologies including α-synucleinopathy.

2016 Journal of Alzheimer's disease : JAD

83. Screening tools for clinical characteristics of probable REM sleep behavior disorder in patients with Parkinson's disease Full Text available with Trip Pro

Screening tools for clinical characteristics of probable REM sleep behavior disorder in patients with Parkinson's disease The REM sleep behavior disorder (RBD) screening questionnaire (RBDSQ) has been used as a screening tool for RBD. We investigated the clinical characteristics of probable RBD (pRBD) using the RBDSQ in patients with Parkinson's disease (PD).Seventy patients with PD (age: 69.2 ± 8.9 years old, 31 males and 49 females, length of PD morbidity: 7.4 ± 6.4 years, Hoehn and Yahr: 2.7

2016 eNeurologicalSci

84. Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep Behavior Disorder

. The investigators hypothesize that PD patients with RBD have a more severe dysfunction of the reward system (hypoactivation of the meso-cortico-limbic pathway) than patients without RBD, explaining their susceptibility to ICD when exposed to high doses of dopaminergic treatment. Condition or disease Intervention/treatment Phase Parkinson's Disease REM Sleep Behavior Disorder Device: fMRI Not Applicable Detailed Description: Type of study: Prospective, case control study. Number of centers: 2 (Clermont-Ferrand (...) Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep Behavior Disorder Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep Behavior Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2016 Clinical Trials

85. Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson Disease

in the treatment of rapid eye movement behavior disorder (RBD) of patients with Parkinson's disease (PD). Condition or disease Intervention/treatment Phase REM Sleep Behavior Disorder Parkinson Disease Drug: Melatonin PR Drug: Clonazepam Drug: Melatonin PR placebo Drug: Clonazepam placebo Phase 2 Detailed Description: RBD is one of the representative non-motor symptoms of PD. Patients with RBD show dream-enacting behaviors such as punching, kicking, singing, screaming, or somnambulism. These can interfere (...) Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson Disease Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2016 Clinical Trials

86. REM sleep behavior disorder was associated with Parkinson's disease: a community-based study. Full Text available with Trip Pro

REM sleep behavior disorder was associated with Parkinson's disease: a community-based study. Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the association between pRBD and Parkinson's disease (PD).The validation study of RBD1Q-C included 32 Chinese participants (14 idiopathic RBD patients and 18 controls). All participants underwent

2016 BMC Neurology

87. Genetic inactivation of glutamate neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder. Full Text available with Trip Pro

in paradoxical sleep regulation, they are, however, not necessary for inducing the state itself. The present work further validates a potent new preclinical REM sleep behaviour disorder model that opens avenues for studying and treating this disabling sleep disorder, and advances potential regions implicated in prodromal stages of synucleinopathies such as Parkinson's disease.© The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions (...) Genetic inactivation of glutamate neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder. SEE SCHENCK AND MAHOWALD DOI101093/AWW329 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Idiopathic REM sleep behaviour disorder is characterized by the enactment of violent dreams during paradoxical (REM) sleep in the absence of normal muscle atonia. Accumulating clinical and experimental data suggest that REM sleep behaviour disorder might be due

2016 Brain

88. REM sleep behavior disorder and neuropathology in Parkinson's disease. (Abstract)

REM sleep behavior disorder and neuropathology in Parkinson's disease. Rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with differences in clinical phenotype, including dementia, autonomic loss, and gait dysfunction. The pathological basis for this remains unclear.Parkinson's disease subjects in a longitudinal clinicopathologic study were screened for probable RBD with the Mayo Sleep Questionnaire. After death, semiquantitative analyses were (...) conducted for synuclein, amyloid, neurofibrillary tangles, and cerebrovascular lesions.Forty cases had probable RBD (PD+RBD), and 41 did not (PD-RBD). Despite similar age at death (∼80 y) and disease duration (∼14.5 y), PD+RBD had increased synuclein deposition in all regions examined, with nine of 10 regions significantly different. The Lewy body 10-region total score (scale = 0-40) was 29.5 in PD+RBD versus 24.5 in PD-RBD (Cohen-d effect size = 0.79, P = 0.002). Cerebrovascular lesion burden

2015 Movement Disorders

89. Parkinson disease with REM sleep behavior disorder: Features, α-synuclein, and inflammation. (Abstract)

Parkinson disease with REM sleep behavior disorder: Features, α-synuclein, and inflammation. To investigate clinical features and potential mechanisms involving α-synuclein oligomer and inflammation in patients with Parkinson disease (PD) and probable REM sleep behavior disorder (PRBD).We used the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) to evaluate patients with PD and classified each as PRBD or not probable (NPRBD). Data collection included demographic information (...) and evaluation of clinical symptoms using a series of rating scales. We tested for α-synuclein oligomer and inflammatory factors in CSF and serum. Data analyses included comparisons between PRBD and NPRBD groups and correlation analyses among RBDSQ score and levels of the above factors.The frequency of PRBD in patients with PD was 30.67%. The PRBD group had longer disease duration, more advanced disease stage, more severe motor symptoms, and other more severe nonmotor symptoms, including depression, anxiety

2015 Neurology

90. Progression of cognitive impairments in idiopathic REM sleep behaviour disorder. (Abstract)

Progression of cognitive impairments in idiopathic REM sleep behaviour disorder. Idiopathic REM (rapid eye movement) sleep behaviour disorder (iRBD) has been implicated in cognitive impairments, but there is little evidence about progression of cognitive dysfunction in iRBD.A retrospective follow-up study with patients with iRBD was performed. Conversion to neurodegenerative disorders was analysed by Kaplan-Meier survival analysis. Neuropsychological test results at baseline were compared (...) with disease duration or follow-up duration, and lower executive function at baseline increased conversion risk (p=0.031).Patients with iRBD have cognitive impairments at baseline and progressive cognitive decline over time. Even in idiopathic cases without development of any neurodegenerative disease, degenerative changes in cognition seem to be under way.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company

2015 Neurosurgery and Psychiatry

91. Brain imaging findings in idiopathic REM sleep behavior disorder (RBD) - A systematic review on potential biomarkers for neurodegeneration. (Abstract)

Brain imaging findings in idiopathic REM sleep behavior disorder (RBD) - A systematic review on potential biomarkers for neurodegeneration. Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by the loss of physiological atonia of skeletal muscles with abnormal behavior during dream sleep. RBD may be the initial manifestation of neurodegenerative diseases, particularly of α-synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies (...) (DLB), and multiple system atrophy (MSA). However, gauging the individual risk of subsequent phenoconversion and making assumptions on the type of disease that may subsequently follow RBD is challenging. Over the past years, a growing number of studies have sought to establish reliable neuroimaging markers to detect neurodegenerative brain changes in RBD subjects at the earliest possible stage. The present review summarizes recent advances in brain imaging in RBD and provides recommendations

2016 Sleep medicine reviews

92. Risk factors for probable REM sleep behavior disorder: A community-based study. Full Text available with Trip Pro

Risk factors for probable REM sleep behavior disorder: A community-based study. To examine risk factors for REM sleep behavior disorder (RBD) in a large-scale community-based study.This community-based study included 12,784 Chinese adults (10,556 men and 2,228 women, aged 24 years or older) who were free of Parkinson disease and dementia in 2012. Probable RBD (pRBD) status was determined by a validated questionnaire (Chinese RBD questionnaire-Hong Kong) in 2012. Potential risk factors-including (...) age, sex, smoking, socioeconomic status, physical activity, obesity, consumption of tea (surrogate for caffeine intake) and alcohol, serum concentrations of lipids and glucose, and chronic disease status-were assessed in 2006. Logistic regression was used to calculate odds ratios and 95% confidence intervals and to test differences in prevalence of pRBD across exposures.Prevalence of pRBD was 5.9% in men and 4.1% in women. In the fully adjusted model, risk factors that were significantly

2016 Neurology

93. Expanded Insights into Idiopathic REM Sleep Behavior Disorder Full Text available with Trip Pro

Expanded Insights into Idiopathic REM Sleep Behavior Disorder 26564130 2016 08 24 2019 01 09 1550-9109 39 1 2016 Jan 01 Sleep Sleep Expanded Insights into Idiopathic REM Sleep Behavior Disorder. 7-9 10.5665/sleep.5300 Schenck Carlos H CH Minnesota Regional Sleep Disorders Center, Hennepin County Medical Center and University of Minnesota Medical School, Minneapolis, MN. eng Journal Article Comment 2016 01 01 United States Sleep 7809084 0161-8105 IM Sleep. 2016 Jan;39(1):121-32 26940460 Humans (...) Polysomnography REM Sleep Behavior Disorder Sleep, REM 2015 10 14 2015 10 30 2015 11 14 6 0 2015 11 14 6 0 2016 8 25 6 0 epublish 26564130 sp-00577-15 10.5665/sleep.5300 PMC4678359 Mov Disord. 2012 Jun;27(7):913-6 22729987 J Sleep Res. 1993 Dec;2(4):224-231 10607098 Sleep Med. 2013 Aug;14(8):734-8 23146747 Sleep Med. 2013 Aug;14(8):795-806 23886593 Sleep. 2002 Mar 15;25(2):120-38 11902423 Sleep Med. 2010 Feb;11(2):167-71 20022299 Sleep. 2005 Feb;28(2):203-6 16171244 Sleep Med. 2011 May;12(5):445-53 21349763 J

2016 Sleep

94. Central Apneas and REM Sleep Behavior Disorder as an Initial Presentation of Multiple System Atrophy Full Text available with Trip Pro

Central Apneas and REM Sleep Behavior Disorder as an Initial Presentation of Multiple System Atrophy We present the case of a patient with multiple system atrophy who presented with central apnea as the only sleep disordered breathing, associated with REM behavior disorder and restless legs syndrome. This presentation of the disease is unusual and probably reflects more widespread involvement at the onset. With this case, we show the importance of considering this kind of disease (...) in the differential diagnosis of central sleep apnea syndromes.© 2015 American Academy of Sleep Medicine.

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

95. Depressed REM Sleep Behavior Disorder Patients Are Less Likely to Recall Enacted Dreams than Non-Depressed Ones Full Text available with Trip Pro

Depressed REM Sleep Behavior Disorder Patients Are Less Likely to Recall Enacted Dreams than Non-Depressed Ones REM sleep behavior disorder (RBD) is associated with psychiatric symptoms, such as anxiety and alexithymia. However, only a few studies on the relationship between depression and RBD have been published. In this study, we investigated the occurrence of depression and associated factors in patients with RBD.In total 94 patients (mean age: 61.9±12.7 years, male: 70.2%) diagnosed as RBD (...) with depression, after controlling for confounding variables including the respiratory disturbance index and a history of psychiatric disorders (odds ratio=0.323, p=0.041).In this study, 44.7% of RBD patients were found to suffer from depressed mood. And, depression was found to be associated with reduced ability to recall enacted dreams. We suggest that routine evaluation of depression be performed in RBD patients, particularly when failure to recall enacted dreams is evident. We speculate that such failure

2016 Psychiatry investigation

96. REM sleep behavior disorder (RBD): Update on diagnosis and treatment Full Text available with Trip Pro

REM sleep behavior disorder (RBD): Update on diagnosis and treatment REM sleep behavior disorder (RBD) is parasomnia characterized by dream enactment and enabled by disruption of physiological muscle atonia during REM sleep. Over the past few years, diagnostic criteria and the methods used to confirm diagnosis have been updated.In this review article, the current knowledge regarding RBD diagnosis and treatment is presented.A selective literature search was carried out.Although several RBD (...) screening questionnaires have been developed, diagnosis can only be definitely confirmed on the basis of polysomnography. New methods for scoring electromyography (EMG) activity during REM sleep have been proposed during recent years and cutoff values have been established. The latest cutoff values for scoring EMG activity during REM sleep are included in the International Classification of Sleep Disorders (ICSD). The cutoff of 27 % muscle activity during REM sleep suggested by the Sleep Innsbruck

2016 Somnologie

97. Seeking Good Alternatives to Clonazepam: Suggestions for Future Treatment Trials in REM Sleep Behavior Disorder Full Text available with Trip Pro

Seeking Good Alternatives to Clonazepam: Suggestions for Future Treatment Trials in REM Sleep Behavior Disorder 27448419 2018 08 17 2018 12 02 1550-9397 12 8 2016 08 15 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine J Clin Sleep Med Seeking Good Alternatives to Clonazepam: Suggestions for Future Treatment Trials in REM Sleep Behavior Disorder. 1195-6 10.5664/jcsm.6070 Esaki Yuichi Y Department of Psychiatry, Fujita Health University (...) School of Medicine, Aichi, Japan. Kitajima Tsuyoshi T Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan. eng Letter Research Support, Non-U.S. Gov't Comment 2016 08 15 United States J Clin Sleep Med 101231977 1550-9389 5PE9FDE8GB Clonazepam IM J Clin Sleep Med. 2016 May 15;12(5):689-93 26857053 J Clin Sleep Med. 2016 Aug 15;12(8):1193 27397658 Clonazepam Humans Polysomnography REM Sleep Behavior Disorder Sleep, REM 2016 07 01 2016 07 01 2016 7 25 6 0 2016 7 28 6 0

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

98. Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD)

Last Update Posted : October 23, 2018 Sponsor: Axovant Sciences Ltd. Information provided by (Responsible Party): Axovant Sciences Ltd. Study Details Study Description Go to Brief Summary: This study seeks to evaluate the safety and efficacy of Nelotanserin for the treatment of Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD). Condition or disease Intervention/treatment Phase Dementia With Lewy Bodies REM (...) participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: A Phase 2, Double-blind, Randomized, Placebo-controlled Study of Nelotanserin Versus Placebo in Subjects With Dementia With Lewy Bodies (DLB) or Parkinson's Disease Dementia (PDD) Who Have REM Sleep Behavior Disorder (RBD) Actual Study Start Date : March 2016 Actual Primary Completion Date : May 2018 Actual

2016 Clinical Trials

99. Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder

and other premotor symptoms of Lewy body disease. This study also collects gene extracts and sera to develop a biomarker for early detection of neurodegeneration. Condition or disease Intervention/treatment Phase Parkinson Disease REM Sleep Behavior Disorder Other: testing, evaluation, sampling Not Applicable Detailed Description: This study will include 3 groups in relation with RBD: idiopathic RBD (iRBD), PD- RBD, normal controls without RBD. In all groups, neurological examinations, olfactory (...) Professor, Seoul National University Hospital ClinicalTrials.gov Identifier: Other Study ID Numbers: 16-2013-101 First Posted: December 6, 2016 Last Update Posted: April 17, 2018 Last Verified: April 2018 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: Undecided Keywords provided by Jee-Young Lee, Seoul National University Hospital: Lewy body disease REM Sleep Behavior Disorder Parkinson disease Imaging Bio-markers Prospective cohort Additional relevant MeSH terms: Layout table

2016 Clinical Trials

100. Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder

: August 18, 2016 Last Update Posted : October 23, 2018 Sponsor: Axovant Sciences Ltd. Information provided by (Responsible Party): Axovant Sciences Ltd. Study Details Study Description Go to Brief Summary: This study seeks to evaluate the long-term safety and effectiveness of nelotanserin for the treatment of visual hallucinations (VHs) and Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with Lewy body dementia (LBD). Condition or disease Intervention/treatment Phase Lewy Body (...) Dementia Dementia With Lewy Bodies Parkinson's Disease Dementia Visual Hallucinations REM Sleep Behavior Disorder Drug: Nelotanserin Phase 2 Detailed Description: This is a multi-center open-label, long-term study in LBD subjects with RBD and/or VHs. Eligible subjects who completed a previous nelotanserin VH or RBD study and choose to participate in this open-label study will receive 20, 40, 60, or 80 mg nelotanserin once daily for 24 weeks. Study Design Go to Layout table for study information Study

2016 Clinical Trials

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