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REM Sleep Behavior Disorder

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81. Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson Disease

in the treatment of rapid eye movement behavior disorder (RBD) of patients with Parkinson's disease (PD). Condition or disease Intervention/treatment Phase REM Sleep Behavior Disorder Parkinson Disease Drug: Melatonin PR Drug: Clonazepam Drug: Melatonin PR placebo Drug: Clonazepam placebo Phase 2 Detailed Description: RBD is one of the representative non-motor symptoms of PD. Patients with RBD show dream-enacting behaviors such as punching, kicking, singing, screaming, or somnambulism. These can interfere (...) Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson Disease Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2016 Clinical Trials

82. REM sleep behavior disorder was associated with Parkinson's disease: a community-based study. Full Text available with Trip Pro

REM sleep behavior disorder was associated with Parkinson's disease: a community-based study. Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the association between pRBD and Parkinson's disease (PD).The validation study of RBD1Q-C included 32 Chinese participants (14 idiopathic RBD patients and 18 controls). All participants underwent

2016 BMC Neurology

83. Genetic inactivation of glutamate neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder. Full Text available with Trip Pro

in paradoxical sleep regulation, they are, however, not necessary for inducing the state itself. The present work further validates a potent new preclinical REM sleep behaviour disorder model that opens avenues for studying and treating this disabling sleep disorder, and advances potential regions implicated in prodromal stages of synucleinopathies such as Parkinson's disease.© The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions (...) Genetic inactivation of glutamate neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder. SEE SCHENCK AND MAHOWALD DOI101093/AWW329 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Idiopathic REM sleep behaviour disorder is characterized by the enactment of violent dreams during paradoxical (REM) sleep in the absence of normal muscle atonia. Accumulating clinical and experimental data suggest that REM sleep behaviour disorder might be due

2016 Brain

84. REM sleep behavior disorder and neuropathology in Parkinson's disease. (Abstract)

REM sleep behavior disorder and neuropathology in Parkinson's disease. Rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with differences in clinical phenotype, including dementia, autonomic loss, and gait dysfunction. The pathological basis for this remains unclear.Parkinson's disease subjects in a longitudinal clinicopathologic study were screened for probable RBD with the Mayo Sleep Questionnaire. After death, semiquantitative analyses were (...) conducted for synuclein, amyloid, neurofibrillary tangles, and cerebrovascular lesions.Forty cases had probable RBD (PD+RBD), and 41 did not (PD-RBD). Despite similar age at death (∼80 y) and disease duration (∼14.5 y), PD+RBD had increased synuclein deposition in all regions examined, with nine of 10 regions significantly different. The Lewy body 10-region total score (scale = 0-40) was 29.5 in PD+RBD versus 24.5 in PD-RBD (Cohen-d effect size = 0.79, P = 0.002). Cerebrovascular lesion burden

2015 Movement Disorders

85. Parkinson disease with REM sleep behavior disorder: Features, α-synuclein, and inflammation. (Abstract)

Parkinson disease with REM sleep behavior disorder: Features, α-synuclein, and inflammation. To investigate clinical features and potential mechanisms involving α-synuclein oligomer and inflammation in patients with Parkinson disease (PD) and probable REM sleep behavior disorder (PRBD).We used the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) to evaluate patients with PD and classified each as PRBD or not probable (NPRBD). Data collection included demographic information (...) and evaluation of clinical symptoms using a series of rating scales. We tested for α-synuclein oligomer and inflammatory factors in CSF and serum. Data analyses included comparisons between PRBD and NPRBD groups and correlation analyses among RBDSQ score and levels of the above factors.The frequency of PRBD in patients with PD was 30.67%. The PRBD group had longer disease duration, more advanced disease stage, more severe motor symptoms, and other more severe nonmotor symptoms, including depression, anxiety

2015 Neurology

86. Progression of cognitive impairments in idiopathic REM sleep behaviour disorder. (Abstract)

Progression of cognitive impairments in idiopathic REM sleep behaviour disorder. Idiopathic REM (rapid eye movement) sleep behaviour disorder (iRBD) has been implicated in cognitive impairments, but there is little evidence about progression of cognitive dysfunction in iRBD.A retrospective follow-up study with patients with iRBD was performed. Conversion to neurodegenerative disorders was analysed by Kaplan-Meier survival analysis. Neuropsychological test results at baseline were compared (...) with disease duration or follow-up duration, and lower executive function at baseline increased conversion risk (p=0.031).Patients with iRBD have cognitive impairments at baseline and progressive cognitive decline over time. Even in idiopathic cases without development of any neurodegenerative disease, degenerative changes in cognition seem to be under way.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company

2015 Neurosurgery and Psychiatry

87. Risk factors for probable REM sleep behavior disorder: A community-based study. Full Text available with Trip Pro

Risk factors for probable REM sleep behavior disorder: A community-based study. To examine risk factors for REM sleep behavior disorder (RBD) in a large-scale community-based study.This community-based study included 12,784 Chinese adults (10,556 men and 2,228 women, aged 24 years or older) who were free of Parkinson disease and dementia in 2012. Probable RBD (pRBD) status was determined by a validated questionnaire (Chinese RBD questionnaire-Hong Kong) in 2012. Potential risk factors-including (...) age, sex, smoking, socioeconomic status, physical activity, obesity, consumption of tea (surrogate for caffeine intake) and alcohol, serum concentrations of lipids and glucose, and chronic disease status-were assessed in 2006. Logistic regression was used to calculate odds ratios and 95% confidence intervals and to test differences in prevalence of pRBD across exposures.Prevalence of pRBD was 5.9% in men and 4.1% in women. In the fully adjusted model, risk factors that were significantly

2016 Neurology

88. Expanded Insights into Idiopathic REM Sleep Behavior Disorder Full Text available with Trip Pro

Expanded Insights into Idiopathic REM Sleep Behavior Disorder 26564130 2016 08 24 2019 01 09 1550-9109 39 1 2016 Jan 01 Sleep Sleep Expanded Insights into Idiopathic REM Sleep Behavior Disorder. 7-9 10.5665/sleep.5300 Schenck Carlos H CH Minnesota Regional Sleep Disorders Center, Hennepin County Medical Center and University of Minnesota Medical School, Minneapolis, MN. eng Journal Article Comment 2016 01 01 United States Sleep 7809084 0161-8105 IM Sleep. 2016 Jan;39(1):121-32 26940460 Humans (...) Polysomnography REM Sleep Behavior Disorder Sleep, REM 2015 10 14 2015 10 30 2015 11 14 6 0 2015 11 14 6 0 2016 8 25 6 0 epublish 26564130 sp-00577-15 10.5665/sleep.5300 PMC4678359 Mov Disord. 2012 Jun;27(7):913-6 22729987 J Sleep Res. 1993 Dec;2(4):224-231 10607098 Sleep Med. 2013 Aug;14(8):734-8 23146747 Sleep Med. 2013 Aug;14(8):795-806 23886593 Sleep. 2002 Mar 15;25(2):120-38 11902423 Sleep Med. 2010 Feb;11(2):167-71 20022299 Sleep. 2005 Feb;28(2):203-6 16171244 Sleep Med. 2011 May;12(5):445-53 21349763 J

2016 Sleep

89. Central Apneas and REM Sleep Behavior Disorder as an Initial Presentation of Multiple System Atrophy Full Text available with Trip Pro

Central Apneas and REM Sleep Behavior Disorder as an Initial Presentation of Multiple System Atrophy We present the case of a patient with multiple system atrophy who presented with central apnea as the only sleep disordered breathing, associated with REM behavior disorder and restless legs syndrome. This presentation of the disease is unusual and probably reflects more widespread involvement at the onset. With this case, we show the importance of considering this kind of disease (...) in the differential diagnosis of central sleep apnea syndromes.© 2015 American Academy of Sleep Medicine.

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

90. Depressed REM Sleep Behavior Disorder Patients Are Less Likely to Recall Enacted Dreams than Non-Depressed Ones Full Text available with Trip Pro

Depressed REM Sleep Behavior Disorder Patients Are Less Likely to Recall Enacted Dreams than Non-Depressed Ones REM sleep behavior disorder (RBD) is associated with psychiatric symptoms, such as anxiety and alexithymia. However, only a few studies on the relationship between depression and RBD have been published. In this study, we investigated the occurrence of depression and associated factors in patients with RBD.In total 94 patients (mean age: 61.9±12.7 years, male: 70.2%) diagnosed as RBD (...) with depression, after controlling for confounding variables including the respiratory disturbance index and a history of psychiatric disorders (odds ratio=0.323, p=0.041).In this study, 44.7% of RBD patients were found to suffer from depressed mood. And, depression was found to be associated with reduced ability to recall enacted dreams. We suggest that routine evaluation of depression be performed in RBD patients, particularly when failure to recall enacted dreams is evident. We speculate that such failure

2016 Psychiatry investigation

91. REM sleep behavior disorder (RBD): Update on diagnosis and treatment Full Text available with Trip Pro

REM sleep behavior disorder (RBD): Update on diagnosis and treatment REM sleep behavior disorder (RBD) is parasomnia characterized by dream enactment and enabled by disruption of physiological muscle atonia during REM sleep. Over the past few years, diagnostic criteria and the methods used to confirm diagnosis have been updated.In this review article, the current knowledge regarding RBD diagnosis and treatment is presented.A selective literature search was carried out.Although several RBD (...) screening questionnaires have been developed, diagnosis can only be definitely confirmed on the basis of polysomnography. New methods for scoring electromyography (EMG) activity during REM sleep have been proposed during recent years and cutoff values have been established. The latest cutoff values for scoring EMG activity during REM sleep are included in the International Classification of Sleep Disorders (ICSD). The cutoff of 27 % muscle activity during REM sleep suggested by the Sleep Innsbruck

2016 Somnologie

92. Seeking Good Alternatives to Clonazepam: Suggestions for Future Treatment Trials in REM Sleep Behavior Disorder Full Text available with Trip Pro

Seeking Good Alternatives to Clonazepam: Suggestions for Future Treatment Trials in REM Sleep Behavior Disorder 27448419 2018 08 17 2018 12 02 1550-9397 12 8 2016 08 15 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine J Clin Sleep Med Seeking Good Alternatives to Clonazepam: Suggestions for Future Treatment Trials in REM Sleep Behavior Disorder. 1195-6 10.5664/jcsm.6070 Esaki Yuichi Y Department of Psychiatry, Fujita Health University (...) School of Medicine, Aichi, Japan. Kitajima Tsuyoshi T Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan. eng Letter Research Support, Non-U.S. Gov't Comment 2016 08 15 United States J Clin Sleep Med 101231977 1550-9389 5PE9FDE8GB Clonazepam IM J Clin Sleep Med. 2016 May 15;12(5):689-93 26857053 J Clin Sleep Med. 2016 Aug 15;12(8):1193 27397658 Clonazepam Humans Polysomnography REM Sleep Behavior Disorder Sleep, REM 2016 07 01 2016 07 01 2016 7 25 6 0 2016 7 28 6 0

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

93. Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD)

Last Update Posted : October 23, 2018 Sponsor: Axovant Sciences Ltd. Information provided by (Responsible Party): Axovant Sciences Ltd. Study Details Study Description Go to Brief Summary: This study seeks to evaluate the safety and efficacy of Nelotanserin for the treatment of Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD). Condition or disease Intervention/treatment Phase Dementia With Lewy Bodies REM (...) participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: A Phase 2, Double-blind, Randomized, Placebo-controlled Study of Nelotanserin Versus Placebo in Subjects With Dementia With Lewy Bodies (DLB) or Parkinson's Disease Dementia (PDD) Who Have REM Sleep Behavior Disorder (RBD) Actual Study Start Date : March 2016 Actual Primary Completion Date : May 2018 Actual

2016 Clinical Trials

94. Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder

and other premotor symptoms of Lewy body disease. This study also collects gene extracts and sera to develop a biomarker for early detection of neurodegeneration. Condition or disease Intervention/treatment Phase Parkinson Disease REM Sleep Behavior Disorder Other: testing, evaluation, sampling Not Applicable Detailed Description: This study will include 3 groups in relation with RBD: idiopathic RBD (iRBD), PD- RBD, normal controls without RBD. In all groups, neurological examinations, olfactory (...) Professor, Seoul National University Hospital ClinicalTrials.gov Identifier: Other Study ID Numbers: 16-2013-101 First Posted: December 6, 2016 Last Update Posted: April 17, 2018 Last Verified: April 2018 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: Undecided Keywords provided by Jee-Young Lee, Seoul National University Hospital: Lewy body disease REM Sleep Behavior Disorder Parkinson disease Imaging Bio-markers Prospective cohort Additional relevant MeSH terms: Layout table

2016 Clinical Trials

95. Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder

: August 18, 2016 Last Update Posted : October 23, 2018 Sponsor: Axovant Sciences Ltd. Information provided by (Responsible Party): Axovant Sciences Ltd. Study Details Study Description Go to Brief Summary: This study seeks to evaluate the long-term safety and effectiveness of nelotanserin for the treatment of visual hallucinations (VHs) and Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with Lewy body dementia (LBD). Condition or disease Intervention/treatment Phase Lewy Body (...) Dementia Dementia With Lewy Bodies Parkinson's Disease Dementia Visual Hallucinations REM Sleep Behavior Disorder Drug: Nelotanserin Phase 2 Detailed Description: This is a multi-center open-label, long-term study in LBD subjects with RBD and/or VHs. Eligible subjects who completed a previous nelotanserin VH or RBD study and choose to participate in this open-label study will receive 20, 40, 60, or 80 mg nelotanserin once daily for 24 weeks. Study Design Go to Layout table for study information Study

2016 Clinical Trials

96. Idiopathic REM sleep behavior disorder and neurodegenerative risk: To tell or not to tell to the patient? How to minimize the risk? (Abstract)

Idiopathic REM sleep behavior disorder and neurodegenerative risk: To tell or not to tell to the patient? How to minimize the risk? Most people with idiopathic REM sleep behavior disorder (iRBD) have an underlying synucleinopathy, mainly Parkinson's disease (PD) or dementia with Lewy bodies, with median conversion time of 4-9 y from iRBD diagnosis and of 11-16 y from symptom onset. Subtle signs and imaging tests indicate concomitant neurodegeneration in widespread brain areas. Risk factor (...) studies suggest that iRBD patients may have prior head injury, occupational farming, pesticide exposure, low education level and possibly more frequent family history of dream-enactment behavior (but not of PD), plus unexpected risk factors (smoking, ischemic heart disease and inhaled corticosteroid use). Unlike PD, caffeine and smoking appear not to have a protective role. Prior depression and antidepressant use may be early neurodegenerative signs rather than exclusively causative factors. Age

2016 Sleep medicine reviews

97. Nocturnal REM Sleep Without Atonia Is a Diagnostic Biomarker of Pediatric Narcolepsy Full Text available with Trip Pro

Nocturnal REM Sleep Without Atonia Is a Diagnostic Biomarker of Pediatric Narcolepsy Compare nocturnal REM sleep without atonia (nRWA) and REM sleep behavior disorder (RBD) between pediatric patients with and without narcolepsy and determine if the nRWA index is a valid diagnostic biomarker for narcolepsy.Retrospective cohort study of children ages 6 to 18 years who completed a nocturnal polysomnogram (PSG) and Multiple Sleep Latency Test (MSLT). Our study sample included 11 patients (...) with narcolepsy type 1 (NT1), 6 with narcolepsy type 2 (NT2), 12 with idiopathic hypersomnia (IH), and 11 with subjective hypersomnia (sHS). We compared group nRWA indices (epochs of RWA/total stage R sleep epochs) from the nocturnal PSGs and analyzed nRWA index receiver operating curve (ROC) statistics for narcolepsy diagnosis.The median nRWA index of patients with NT1 was 15 to 30 times higher compared to sHS and IH (Ps < .005) but similar to that of the NT2 group (P = .46). RBD was present in 25

2018 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

98. A Particular Medullary-Spinal Inhibitory Pathway is Recruited for the Expression of Muscle Atonia During REM Sleep Full Text available with Trip Pro

A Particular Medullary-Spinal Inhibitory Pathway is Recruited for the Expression of Muscle Atonia During REM Sleep Muscle atonia is a major pathognomonic sign of paradoxical sleep (PS; coined REM Sleep), during which dreams mainly occur. In the 1980s, an idiopathic syndrome called REM sleep behavior disorder (RBD) was described in patients endowed with loss of PS paralysis concomitant to abnormal movements, suggesting a dysfunction of PS networks. Another major clinical RBD feature is its (...) prevalent phenoconversion into synucleinopathies as Parkinson's disease in a delay of 10-15 years after diagnosis. Thus, we undertook experiments in rats to disentangle brainstem networks involved in PS, including atonia. We first identified a contingent of pontine glutamate neurons recruited during PS with inputs to the ventromedial medulla (vmM) where they contact γ-aminobutyric acid (GABA)/glycine inhibitory neurons also activated during PS. Here, we further show that these vmM inhibitory neurons

2018 Journal of Experimental Neuroscience

99. Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies Full Text available with Trip Pro

Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by repeated episodes of REM sleep-related vocalizations and/or complex motor behaviors. Definite diagnosis of RBD is based on history and polysomnography, both of which are less accessible due to the lack of trained specialists and high (...) cost. While RBD may be associated with disorders like narcolepsy, focal brain lesions, and encephalitis, idiopathic RBD (iRBD) may convert to Parkinson's disease (PD) and other synucleinopathies in more than 80% of patients and it is to date the most specific clinical prodromal marker of PD. Identification of individuals at high risk for development of PD is becoming one of the most important topics for current PD-related research as well as for future treatment trials targeting prodromal PD

2018 Frontiers in neurology

100. Sleep-Dependent Consolidation of Rewarded Behavior Is Diminished in Children with Attention Deficit Hyperactivity Disorder and a Comorbid Disorder of Social Behavior Full Text available with Trip Pro

Sleep-Dependent Consolidation of Rewarded Behavior Is Diminished in Children with Attention Deficit Hyperactivity Disorder and a Comorbid Disorder of Social Behavior Children suffering from attention-deficit hyperactivity disorder (ADHD) often also display impaired learning and memory. Previous research has documented aberrant reward processing in ADHD as well as impaired sleep-dependent consolidation of declarative memory. We investigated whether sleep also fosters the consolidation (...) of either sleep at night or wakefulness during the day, a reversal task was presented where the contingencies were reversed. Consolidation of rewarded behavior is indicated by greater resistance to reversal learning. We found that healthy children consolidate rewarded behavior better during a night of sleep than during a day awake and that the sleep-dependent consolidation of rewarded behavior by trend correlates with non-REM sleep but not with REM sleep. In contrast, children with ADHD and comorbid

2017 Frontiers in psychology

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