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REM Sleep Behavior Disorder

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841. Core and Suggestive Symptoms of Dementia with Lewy Bodies Cluster in Persons with Mild Dementia. (Abstract)

to classify persons into groups according to scores on scales for hallucinations, parkinsonism, fluctuations and REM sleep behaviour disorder (RBD).Four distinct clusters were revealed: a 'Lewy body dementia' (LBD) cluster with high scores for hallucinations, parkinsonism and fluctuation, and a 'non-LBD' cluster with low scores on all DLB symptom scales. In addition, 2 clusters with high scores on either RBD or cognitive fluctuation scales emerged. Persons in the LBD cluster had lower scores

2010 Dementia and Geriatric Cognitive Disorders

842. An Exploratory Study of a Nasal Dilator Strip

of the nasal dilator strip in lowering nasal resistance during sleep, promoting nasal route breathing and reducing the signs and symptoms of sleep disordered breathing in a group of chronic nocturnal nasal congestion sufferers who report trouble with their sleep. Condition or disease Intervention/treatment Phase Sleep Disordered Breathing Device: Prototype nasal dilator strip Other: No Strip Phase 2 Detailed Description: This study was a baseline-controlled study. This study consisted of four phases (...) skin condition or eczema on the face or nose. Subject has visible open sores, sunburn, irritation on the face or nose immediately prior to treatment. Subject has severe obstructive sleep apnea/hypopnea syndrome with an AHI score <30 events/hour at the Baseline visit. Subject has had a diagnosis of another major sleep disorder (i.e. primary insomnia, i.e. regularly sleeping less than 6 hours per night, sleep insufficiency, i.e. sleeping >2 hours more on non-work days as compared to work days

2009 Clinical Trials

843. Pilot Study of Melatonin and Epilepsy

to Brief Summary: The prevalence of epilepsy is 1% in the USA. About 30% of epilepsy patients eventually become refractory to medical treatment. Co morbid conditions are becoming as important as seizure control as these affect overall wellbeing. Sleep related complaints are frequent in them including, frequent arousals, difficulty falling asleep and excessive daytime sleepiness. Polysomnography shows increased arousal index, sleep onset latency, and stage shifts and fragmented REM sleep. Poor sleep (...) functioning, it is important to study effect of melatonin in children with epilepsy. We propose a randomized double blind placebo controlled trial with a cross-over design. Our hypothesis is that, for patients with epilepsy, administration of melatonin 30 minutes before bedtime for four weeks may: Improve the quality of sleep; Improve daytime functioning in terms of cognition, behavior and quality of life; Decrease epileptic potential. We will use polysomnography, electroencephalogram, psychomotor

2009 Clinical Trials

844. Polysomnography Study Of Pregabalin And Pramipexole Versus Placebo In Patients With Restless Legs Syndrome And Associated Sleep Disturbance

Identifier: NCT00991276 Recruitment Status : Completed First Posted : October 7, 2009 Results First Posted : October 8, 2012 Last Update Posted : October 8, 2012 Sponsor: Pfizer Information provided by (Responsible Party): Pfizer Study Details Study Description Go to Brief Summary: The purpose of this study is to assess the efficacy and safety of pregabalin and pramipexole versus placebo in the treatment of restless legs syndrome and associated sleep disturbance. Condition or disease Intervention (...) Restless Legs Syndrome Disease Pathologic Processes Dyskinesias Neurologic Manifestations Nervous System Diseases Psychomotor Disorders Neurobehavioral Manifestations Signs and Symptoms Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Parasomnias Mental Disorders Pregabalin Pramipexole Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological

2009 Clinical Trials

845. Ramelteon for Insomnia Comorbid With Asthma

. Exclusion Criteria: Primary sleep pathology, other than insomnia as assessed by sleep history and confirmed by polysomnography to exclude significant sleep apnea (RDI > 15), periodic leg movements (movement arousal index > 15), REM behavior disorder; or circadian sleep-wake disorders History of cognitive or other neurological disorders; History of DSM-IV criteria for any major psychiatric disorder, including mania or alcohol or substance abuse; Depressive symptoms as assessed by the CES-D. Subjects (...) Disorders Bronchial Diseases Respiratory Tract Diseases Lung Diseases, Obstructive Lung Diseases Respiratory Hypersensitivity Hypersensitivity, Immediate Hypersensitivity Immune System Diseases Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Nervous System Diseases Mental Disorders

2009 Clinical Trials

846. Psychology of Reward and Punishment: Functional and Molecular Brain Imaging and Monoaminergic Correlates

during the PET scanning sessions. Participants will have short breaks during the PET scanning sessions. Condition or disease Cocaine Addiction Cocaine Abuse Detailed Description: Objective: This protocol will integrate functional brain imaging of reward processing, together with assessment of the response to oral dextroamphetamine (d-AMPH), monoaminergic genotyping, and evaluation of past exposure to stress, in order to examine: (1) the relationship between these factors (i.e. dopamine function (...) for female participants. Subjects who have previously had significant exposure to medications that act on the DA system (antipsychotics, psychostimulants) will also be excluded from the study. CNS disease: History of known structural brain abnormalities (e.g. neoplasm, subarachnoid cysts), cerebrovascular disease, infectious disease (e.g. abscess), history of head trauma (defined as documented loss of consciousness > 5 min or injury requiring hospitalization), history of seizures as an adult, sleep apnea

2009 Clinical Trials

847. Study of Provent Treatment of Obstructive Sleep Apnea in Patients Who Are Non-compliant With CPAP

low blood pressure. Narcolepsy, idiopathic hypersomnolence, chronic insomnia, restless legs syndrome, REM sleep behavior disorder or any other diagnosed or suspected sleep disorder other than OSA that could affect the likelihood of apneas/hypopneas during a PSG. Periodic limb movement arousal index (PLMAI) > 10 on the screening/baseline PSG. Current use of diurnal or nocturnal supplemental oxygen Currently working night or rotating shifts Consumption of > 10 caffeinated beverages per day (...) ClinicalTrials.gov Identifier: Other Study ID Numbers: Ventus C020 First Posted: May 14, 2009 Last Update Posted: June 15, 2010 Last Verified: June 2010 Keywords provided by St. Luke's Hospital, Chesterfield, Missouri: Sleep Sleep Apnea, Obstructive OSA OSAH Additional relevant MeSH terms: Layout table for MeSH terms Apnea Sleep Apnea Syndromes Sleep Apnea, Obstructive Respiration Disorders Respiratory Tract Diseases Signs and Symptoms, Respiratory Signs and Symptoms Sleep Disorders, Intrinsic Dyssomnias Sleep

2009 Clinical Trials

848. Safety & Efficacy Study of Study Drug (Eszopiclone) in Children and Adolescents With Attention-deficit/Hyperactivity Disorder

percentile for age and gender Subject has any clinically significant or unstable medical illness/abnormality or chronic disease. Subject has a documented history of Bipolar I or II Disorder, major depression, conduct disorder, generalized anxiety disorder or any history of psychosis. Subject has periodic limb movement >5 times per hour, as demonstrated on Baseline PSG. Subject has sleep disordered breathing, as demonstrated on Baseline PSG. Subject has another primary sleep disorder, a secondary sleep (...) disorder, or any other known or suspected medical or psychiatric condition that has affected or may affect sleep Subject has a history of circadian rhythm disorder or will travel across ≥3 time zones more than once during the study. Subject has organic brain disease, or a history of febrile seizures. Subject is, in the opinion of the investigator, at suicidal or homicidal risk. Female subject who is pregnant or lactating or planning to become pregnant. Subject has taken any psychotropic medication

2009 Clinical Trials

849. RBD Longitudinal as Prognostic for PD

): Mya Schiess, The University of Texas Health Science Center, Houston Study Details Study Description Go to Brief Summary: Purpose - to validate a combination of biological and clinical markers in the rapid-eye-movement (REM) sleep behavior disorder (RBD) population as indicative of the pre-symptomatic stage of Parkinson's disease (PD). Procedures - All subjects (RBD diagnosis and controls) will have 1) a medical and neuro history and physical including videotape of movements, 2) neuropsychological (...) subjects who will be diagnosed. Subjects may be offered a repeat enrollment after 5 years. Condition or disease Rapid Eye Movement Sleep Behavior Disorder Detailed Description: Enrollment of PD and PS cohorts is complete. Currently enrolling only confirmed RBD and Controls. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 240 participants Observational Model: Case-Control Time Perspective: Prospective Official Title: A Natural History Analysis

2009 Clinical Trials

850. Efficacy and Safety of Ramelteon on Chronic Insomnia

response of Ramelteon, once daily (QD), in Japanese subjects with Chronic Insomnia Condition or disease Intervention/treatment Phase Chronic Insomnia Drug: Ramelteon and Placebo (25 possible combinations total) Phase 2 Detailed Description: Complaints of sleep disorder are increasing with today's aging society and changing lifestyle. Sleep disorders not only impact one's activities of daily living, but also impede one's social life, leading to reduced productivity and sometimes accidents through (...) to use a medically accepted means of contraception, and can neither be pregnant nor lactating from Screening throughout the duration of the study. Exclusion Criteria: Has a history of psychiatric disorder (including depression and anxiety), seizures, drug addiction, sleep apnea, nocturnal myoclonus and/or mental retardation as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Has a history of alcohol abuse within the previous 2 years. Has a hepatic disease

2009 Clinical Trials

851. Treating Sleep/Wake Cycle Disturbances in Basal Ganglia Disorders With Ramelteon

and DLB. The study also aims to look at the sleep patterns of caregivers of people with HD, PD and DLB. Condition or disease Intervention/treatment Phase Huntington's Disease Parkinson's Disease Dementia With Lewy Bodies Sleep Disorders Circadian Dysregulation Drug: Ramelteon Drug: Placebo Not Applicable Detailed Description: Huntington's disease (HD) is a progressively degenerative brain disorder, which results in a loss of mental and physical abilities. It is genetically determined and people (...) to the patients and their caregivers' lives. In PD, sleep dysfunction occurs in approximately two thirds of patients. Sleep problems range from difficulty with sleep initiation, sleep fragmentation, disturbance of circadian rhythm, REM sleep behavior disorder (RBD), to excessive daytime sleepiness. Frequent nighttime awakening and sleep disruption are the most common sleep problems in PD. In DLB, REM sleep behavior disorder (RBD) occurs years to decades before the onset of dementia. Importantly, melatonin

2009 Clinical Trials

852. Study to Evaluate the Efficacy and Safety of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury

. The patient required, or was likely to require, treatment with anticonvulsant medication during the study, or had taken anticonvulsant medication within 6 months before the screening visit. The patient had an unstable or uncontrolled medical (including illnesses related to the cardiovascular [including patients with a history of left ventricular hypertrophy or in patients with mitral valve prolapse who had experienced the mitral valve prolapse syndrome], renal, or hepatic systems or surgical) condition (...) , Fourth Edition, Text Revision (SCID). The patient had any Axis II disorder (as assessed by SCID) that, in the opinion of the investigator, would affect patient participation in the study or full compliance with study procedures. The patient had a history of, or currently met The International Classification of Sleep Disorders, Edition 2 (ICSD 2) (American Academy of Sleep Medicine 2005) criteria for narcolepsy, obstructive sleep apnea/hypopnea syndrome (OSAHS), shift work sleep disorder (SWSD

2009 Clinical Trials

853. Uncovering the Genetic Landscape for Multiple Sleep-Wake Traits Full Text available with Trip Pro

Uncovering the Genetic Landscape for Multiple Sleep-Wake Traits Despite decades of research in defining sleep-wake properties in mammals, little is known about the nature or identity of genes that regulate sleep, a fundamental behaviour that in humans occupies about one-third of the entire lifespan. While genome-wide association studies in humans and quantitative trait loci (QTL) analyses in mice have identified candidate genes for an increasing number of complex traits and genetic diseases (...) or dark period while some loci had opposite effects on the trait during the light vs. dark. Analysis of a dataset for multiple sleep-wake traits led to previously undetected interactions (including the differential genetic control of number and duration of REM bouts), as well as possible shared genetic regulatory mechanisms for seemingly different unrelated sleep-wake traits (e.g., number of arousals and REM latency). Construction of a Bayesian network for sleep-wake traits and loci led

2009 PloS one

854. Disappearance of “phantom limb” and amputated arm usage during dreaming in REM sleep behaviour disorder Full Text available with Trip Pro

Disappearance of “phantom limb” and amputated arm usage during dreaming in REM sleep behaviour disorder Limb amputation is followed, in approximately 90% of patients, by "phantom limb" sensations during wakefulness. When amputated patients dream, however, the phantom limb may be present all the time, part of the time, intermittently or not at all. Such dreaming experiences in amputees have usually been obtained only retrospectively in the morning and, moreover, dreaming is normally (...) associated with muscular atonia so the motor counterpart of the phantom limb experience cannot be observed directly. REM sleep behaviour disorder (RBD), in which muscle atonia is absent during REM sleep and patients act out their dreams, allows a more direct analysis of the "phantom limb" phenomena and their modifications during sleep.

2009 BMJ case reports

855. Motor-Behavioral Episodes in REM Sleep Behavior Disorder and Phasic Events During REM Sleep Full Text available with Trip Pro

Motor-Behavioral Episodes in REM Sleep Behavior Disorder and Phasic Events During REM Sleep To investigate if sudden-onset motor-behavioral episodes in REM sleep behavior disorder (RBD) are associated with phasic events of REM sleep, and to explore the potential meaning of such an association.Observational review analysis.Tertiary sleep center.Twelve individuals (11 males; mean age 67.6 +/- 7.4 years) affected by idiopathic RBD, displaying a total of 978 motor-behavioral episodes during (...) variable (REMs, STWs, alpha bursts) was associated more with purposefullsemi-purposeful than with primitive movements (P<0.05).Motor-behavioral episodes in RBD were significantly more likely to occur in association with phasic than with tonic periods of REM sleep. The presence of REMs, alpha bursts and STWs was found to be more frequent in more complex episodes. We hypothesize that motor-behavioral episodes in RBD are likely to occur when the brain, during REM sleep, is in a state of increased

2009 Sleep

856. Excessive Muscle Activity Increases Over Time in Idiopathic REM Sleep Behavior Disorder Full Text available with Trip Pro

Excessive Muscle Activity Increases Over Time in Idiopathic REM Sleep Behavior Disorder Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by excessive electromyographic (EMG) activity due to dysfunction of the brainstem structures modulating REM sleep atonia. Patients with idiopathic RBD often develop a neurodegenerative disease, such as Parkinson disease, over the years, suggesting progression of an underlying pathologic process in the brainstem. It is unknown (...) if the excessive EMG activity in REM sleep changes over time in patients with idiopathic RBD.University hospital sleep disorders center.Eleven patients with idiopathic RBD who were studied at baseline and after a mean follow-up of 5 years.NA.Eleven patients with idiopathic RBD underwent polysomnography (PSG) at the moment of the diagnosis of RBD (PSG1) and after a mean follow-up of 5 years (PSG2). Tonic EMG activity in PSG1 and PSG2 was blindly quantified and compared in the mentalis muscle during REM sleep

2009 Sleep

857. Idiopathic REM sleep behavior disorder in the transition to degenerative disease. (Abstract)

Idiopathic REM sleep behavior disorder in the transition to degenerative disease. Idiopathic REM sleep behavior disorder (RBD) predicts Parkinson's disease (PD) and dementia. However, the nature of the disease that emerges from RBD has not been fully characterized. Since 2004, we have been conducting a prospective study of idiopathic RBD patients, providing an opportunity to directly observe patients as they transitioned to a defined neurodegenerative syndrome. Patients with idiopathic RBD (...) underwent an extensive annual evaluation of motor function, olfaction, color vision, autonomic function, cognition and psychiatric symptoms. Neurodegenerative disease was defined according to standard criteria. We compared these measures in patients who had developed PD to those with dementia, all within the first year of developing disease. Of 67 patients, 6 developed PD and eleven developed dementia. Except for cognitive functioning, all tests of olfaction, color vision, autonomic function, depression

2009 Movement Disorders

858. Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder. (Abstract)

Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder. Recent studies have reported an increased risk to develop Parkinson's disease (PD) in patients with idiopathic RBD (iRBD). Midbrain hyperechogenicity is a common transcranial sonography (TCS) finding in PD and has been suggested as a PD risk-marker in nonparkinsonian subjects. The objective of this study is to assess midbrain echogenicity by TCS in patients with iRBD and compare the findings with the healthy controls. TCS

2009 Movement Disorders

859. Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two parkin mutations. (Abstract)

Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two parkin mutations. Parkin gene mutations cause a juvenile parkinsonism. Patients with these mutations may commonly exhibit REM sleep behaviour disorders, but other sleep problems (insomnia, sleepiness, restless legs syndrome) have not been studied. The aim of this study was to evaluate the sleep-wake phenotype in patients with two parkin mutations, compared with patients with idiopathic (...) group). Of the parkin patients, 45% had REM sleep without atonia, but only 9% had a definite REM sleep behavior disorder. All sleep measures were similar in the parkin and iPD groups. Two parkin siblings had a central hypersomnia, characterized by mean daytime sleep latencies of 3 min, no sleep onset REM periods, and normal nighttime sleep. Although the patients with two parkin mutations were young, their sleep phenotype paralleled the clinical and polygraphic sleep recording abnormalities reported

2009 Movement Disorders

860. Complex dream-enacting behavior in sleepwalking. (Abstract)

Complex dream-enacting behavior in sleepwalking. Currently, dream-enacting behaviors are viewed as occurring typically in association with a REM-sleep behavior disorder. In some cases, dream-like mentation is found also in non-REM parasomnia.We report a case of complex and dramatic sleepwalking behavior in a 26-year-old adult male who tied his 4-month-old daughter to the clothesline in the attic of his house.The explanation of this seemingly senseless behavior, which was related to psychosocial (...) stressors, was found in a detailed dream-like mentation that was reported by the patient. At the same time, an organic factor, namely, a worsening of the patient's asthma, was identified as the cause of an increased fragmentation of sleep.In some cases of non-REM parasomnia, detailed dream-like mentation may act as a bridge between psychosocial stressors and the specific parasomnic behavior.

2009 Psychosomatic Medicine

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