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REM Sleep Behavior Disorder

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821. Slow-wave sleep and delta power in rapid eye movement sleep behavior disorder. (PubMed)

Slow-wave sleep and delta power in rapid eye movement sleep behavior disorder. Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by the loss of normal muscle atonia during REM sleep, leading to an increase of phasic muscle activity and complex motor behaviors during the night. There is some evidence that RBD patients have more of slow-wave sleep (SWS) than healthy elderly subjects. No study has looked at quantitative electroencephalogram analysis during non-REM sleep (...) with control subjects (p = 002). This study shows an increase of SWS and power in the delta band during non-REM sleep in idiopathic RBD patients compared with control subjects. Results are discussed about the possible nigrostriatal dopaminergic impairment in RBD patients and the association between RBD and neurodegenerative disorders.

2005 Annals of Neurology

822. REM behavior disorder and excessive daytime somnolence in Machado-Joseph disease (SCA-3). (PubMed)

REM behavior disorder and excessive daytime somnolence in Machado-Joseph disease (SCA-3). We reported previously that behavior suggestive of rapid eye movement sleep behavior disorder (RBD) was markedly increased in a small population of SCA-3 patients. We, therefore, asked patients and nonpatient attendees at an SCA-3 annual clinic to complete a questionnaire soliciting RBD-like behavior. Our results support the previous observation that RBD-like behaviors are significantly increased in SCA-3 (...) .Copyright 2003 Movement Disorder Society

2003 Movement Disorders

823. REM behavior disorder associated with epileptic seizures. (PubMed)

REM behavior disorder associated with epileptic seizures. Reported is the association of REM behavior disorder (RBD) with late-onset, sleep-related, tonic-clonic seizures in two elderly men. In each patient, RBD preceded the onset of seizures by several years. The authors hypothesize that REM sleep disruption may facilitate seizure occurrence.

2005 Neurology

824. Disappearance of "Phantom Limb" and amputated arm usage during dreaming in REM sleep behaviour disorder. (PubMed)

Arm innervation Arm Injuries physiopathology psychology surgery Awareness physiology Dreams physiology Hand innervation Humans Kinesthesis physiology Male Middle Aged Phantom Limb diagnosis physiopathology Polysomnography Psychomotor Performance physiology REM Sleep Behavior Disorder physiopathology psychology 2007 11 28 9 0 2008 4 9 9 0 2007 11 28 9 0 ppublish 18039890 jnnp.2007.129783 10.1136/jnnp.2007.129783 (...) Disappearance of "Phantom Limb" and amputated arm usage during dreaming in REM sleep behaviour disorder. 18039890 2008 04 07 2017 11 14 1468-330X 79 4 2008 Apr Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Disappearance of "phantom limb" and amputated arm usage during dreaming in REM sleep behaviour disorder. 481-3 Vetrugno R R Arnulf I I Montagna P P eng Case Reports Letter 2007 11 26 England J Neurol Neurosurg Psychiatry 2985191R 0022-3050 IM Amputation

2007 Neurosurgery and Psychiatry

825. Insights into REM Sleep Behavior Disorder Pathophysiology in Brainstem-Predominant Lewy Body Disease (PubMed)

Insights into REM Sleep Behavior Disorder Pathophysiology in Brainstem-Predominant Lewy Body Disease Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia reflecting changes in the brain, but which specific neuronal networks are involved in human RBD pathogenesis has not yet been determined. To date, only one case of idiopathic RBD has undergone autopsy, in which "incidental Lewy body disease" was found. Due to the severe neuronal loss and gliosis in the substantia nigra (SN

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2006 Sleep medicine

826. Aggressive dream content without daytime aggressiveness in REM sleep behavior disorder. (PubMed)

Aggressive dream content without daytime aggressiveness in REM sleep behavior disorder. REM sleep behavior disorder (RBD) is characterized by vigorous sleep motor activity associated with dream mentation. Patients with RBD frequently report action-filled and violent dreams.To systematically assess dream characteristics and daytime aggressiveness in patients with RBD and controls.Forty-nine patients with polysomnographic-confirmed RBD diagnosis and 71 age- and sex-matched controls were asked (...) subjects (16.5 +/- 6.4 vs 20.4 +/- 8.3; p = 0.034). No correlation was observed between dream aggressiveness and age, duration, or frequency of RBD symptoms.Dreams in patients with REM sleep behavior disorder were characterized by an elevated proportion of aggressive contents, despite normal levels of daytime aggressiveness. Dreams with aggressiveness and the known excessive phasic muscle activity during REM sleep may be related to the hyperactivity of a common neuronal generator.

2005 Neurology

827. Assessing whole brain perfusion changes in patients with REM sleep behavior disorder. (PubMed)

Assessing whole brain perfusion changes in patients with REM sleep behavior disorder. To investigate the regional cerebral perfusion in patients with idiopathic REM behavior disorder (RBD) in order to establish the topography of networks involved.We performed cerebral blood flow evaluation using (99m)Tc-Ethylene Cysteinate Dimer (ECD) SPECT on eight patients with polysomnographically confirmed RBD and nine age-matched controls. Comparisons were made using SPM2.We found increased perfusion (...) in the pons and putamen bilaterally and in the right hippocampus. In addition, we observed a decreased perfusion in frontal (Brodmann area [BA] 4, 6, 10, 43, 44, 47 bilaterally and left BA 9, 46) and temporo-parietal (BA 13, 22, 43 bilaterally and left BA 7, 19, 20, 21, 39, 40, 41, 42) cortices.Perfusional abnormalities in patients with REM behavior disorder were located in the brainstem, striatum, and cortex. These abnormalities are consistent with the anatomic metabolic profile of Parkinson disease.

2006 Neurology

828. Video analysis of motor events in REM sleep behavior disorder. (PubMed)

Video analysis of motor events in REM sleep behavior disorder. In REM sleep behavior disorder (RBD), several studies focused on electromyographic characterization of motor activity, whereas video analysis has remained more general. The aim of this study was to undertake a detailed and systematic video analysis. Nine polysomnographic records from 5 Parkinson patients with RBD were analyzed and compared with sex- and age-matched controls. Each motor event in the video during REM sleep (...) was classified according to duration, type of movement, and topographical distribution. In RBD, a mean of 54 +/- 23.2 events/10 minutes of REM sleep (total 1392) were identified and visually analyzed. Seventy-five percent of all motor events lasted <2 seconds. Of these events, 1,155 (83.0%) were classified as elementary, 188 (13.5%) as complex behaviors, 50 (3.6%) as violent, and 146 (10.5%) as vocalizations. In the control group, 3.6 +/- 2.3 events/10 minutes (total 264) of predominantly elementary simple

2007 Movement Disorders

829. Rhythmic movements in idiopathic REM sleep behavior disorder. (PubMed)

Rhythmic movements in idiopathic REM sleep behavior disorder. Reported are two cases of video-PSG captured head-rolling occurring, in the context of REM Sleep Behavior Disorder (RBD) episodes, in two patients affected with idiopathic RBD and without past personal or familiar history of Rhythmic Movement Disorder during sleep. It has been speculated that the activation of neuronal pathways which underlie REM-related loss of motor control in RBD, may involve the Central Pattern Generator neuronal (...) networks leading to the induction of Rhythmic Movements during RBD episodes, thereby allowing the re-emergence, in pathological conditions in later life, of a motor behavior typically seen in the early stage of life.(c) 2007 Movement Disorder Society.

2007 Movement Disorders

830. Testosterone not associated with violent dreams or REM sleep behavior disorder in men with Parkinson's. (PubMed)

Testosterone not associated with violent dreams or REM sleep behavior disorder in men with Parkinson's. We examined the relationship between testosterone levels, violent dreams, and REM sleep behavior disorder (RBD) in 31 men with Parkinson's disease (PD): 12 with clinical RBD and 19 without. All PD patients with clinical RBD experienced violent dreams, but none of the 19 non-RBD patients reported violent dreams. While dream content appears to be more aggressive in PD patients with clinical RBD

2007 Movement Disorders

831. REM sleep behavior disorder and epileptic phenomena: clinical aspects of the comorbidity. (PubMed)

REM sleep behavior disorder and epileptic phenomena: clinical aspects of the comorbidity. To document the occurrence of REM sleep behavior disorder (RBD) episodes in patients with epilepsy, and of interictal EEG epileptiform abnormalities (IEA) in patients with idiopathic RBD.Consecutive observations in a tertiary epilepsy center and a tertiary sleep center. RBD diagnosis was based on standard clinical and video-polysomnographic findings.Co-occurrence of epileptic seizures and RBD episodes (...) was found in six cases (all men; mean age 70.5 +/- 11.1 years). Focal, isolated, sporadic sharp waves during wakefulness and/or during sleep were documented in 9 out of 34 (26.4%) patients with idiopathic RBD; no significant differences in age at onset and duration of RBD emerged between RBD patients with and without IEA.RBD episodes can occur in epilepsy patients and focal IEA in patients with idiopathic RBD. This, apart from being a possible cause for misdiagnosis, may indicate a possible link between

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2006 Epilepsia

832. Visual hallucinations as REM sleep behavior disorders in patients with Parkinson's disease. (PubMed)

Visual hallucinations as REM sleep behavior disorders in patients with Parkinson's disease. To clarify whether visual hallucinations in patients with Parkinson's disease (PD) are related to rapid eye movement (REM) sleep, nocturnal polysomnographic variables were compared between a group with hallucinations (hallucinators, n = 14) and a group without hallucinations (nonhallucinators, n = 8). A multiple sleep latency test (MSLT) was performed on 3 hallucinators, and the content of dreams during (...) daytime REM sleep was investigated. The efficacy of clonazepam, a standard treatment choice for REM sleep behavior disorders, was investigated in 8 hallucinators. Nocturnal polysomnograms of the hallucinators showed a higher amount of stage 1-REM sleep with tonic electromyogram (stage 1-REM) than the nonhallucinators, and the reported occurrences of nocturnal hallucinations corresponded with the periods of stage REM or stage 1-REM in most hallucinators. The frequency of sleep onset REM periods (SOREMP

2003 Movement Disorders

833. Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD. (PubMed)

Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD. To compare the clinical and video-polysomnographic (VPSG) characteristics of idiopathic REM sleep behavior disorder (RBD) vs the RBD seen in multiple system atrophy (MSA) and Parkinson disease (PD).Clinical features and VPSG measures were evaluated in 110 consecutive nondemented subjects (26 MSA, 45 PD, and 39 idiopathic RBD) free of psychoactive medications referred for suspected RBD to our sleep (...) , a higher REM sleep without atonia percentage, a greater periodic leg movement index, and less total sleep time. Subjects with idiopathic RBD, as compared to those with either MSA or PD, were more often male, had greater self-reported clinical RBD severity, and were more often aware of their abnormal sleep behaviors.REM sleep behavior disorder (RBD)-related symptoms and neurophysiologic features are qualitatively similar in RBD subjects with the idiopathic form, multiple system atrophy (MSA

2005 Neurology

834. REM sleep behavior disorder and vocal cord paralysis in Machado-Joseph disease. (PubMed)

REM sleep behavior disorder and vocal cord paralysis in Machado-Joseph disease. We evaluated the occurrence of REM sleep behaviour disorder (RBD) and vocal cord abductor paralysis (VCAP) in a group of 9 Machado-Joseph disease (MJD) patients. RBD was diagnosed by clinical history plus audiovisual polysomnography in 4 men and 1 woman (55%). While dreaming, 4 fell out of the bed and the other injured his arms. Laryngoscopy detected bilateral VCAP in 1 patient with stridor who required emergency (...) tracheotomy, and partial vocal cord abductor restriction in 2. RBD and VCAP are two potentially injurious conditions that should be considered part of the clinical spectrum of MJD.Copyright 2003 Movement Disorder Society

2003 Movement Disorders

835. Update on the pharmacology of REM sleep behavior disorder. (PubMed)

Update on the pharmacology of REM sleep behavior disorder. REM sleep behavior disorder (RBD) is characterized by complex behavioral manifestations in response to dream content that may cause sleep disruption or injuries to the patient or the bed partner. In this case, the patients need treatment to control their symptoms. Pharmacologic agents have been reported to have positive and negative impacts on REM sleep muscle atonia and the motor behaviors associated with RBD. Clonazepam is efficacious (...) and well tolerated by the majority of patients afflicted by RBD and should be considered as initial treatment. In patients at risk of falls who have cognitive impairment or who have obstructive sleep apneas, melatonin may be a good alternative to clonazepam. Anticholinesterase inhibitors and dopaminergic agents are not of clear benefit. Monoamine oxidase inhibitors, tricyclic antidepressants, serotonergic synaptic reuptake inhibitors, and noradrenergic antagonists can induce or aggravate RBD symptoms

2006 Neurology

836. Occurrence and clinical correlates of REM sleep behavior disorder in patients with Parkinson's disease over time. (PubMed)

Occurrence and clinical correlates of REM sleep behavior disorder in patients with Parkinson's disease over time. To examine the occurrence and clinical and demographic correlates of REM sleep behaviour disorder (RBD) in patients with Parkinson's disease (PD) in a community-based cohort over 8 years.231 patients with PD were included in a population-based prevalence study in 1993. Patients were then followed prospectively and reexamined after 4 and 8 years. Semi-structured interviews (...) for information on clinical and demographic data were applied at all study visits. Standardised rating scales of parkinsonism, depression and cognitive impairment were used. The diagnosis of probable RBD (pRBD) was based on a sleep questionnaire. Proportional-odds ordinal logistic regression models for clustered data were used to study the relationship between pRBD and various demographic and clinical variables.231 patients were evaluated for RBD in 1993 and, after 4 and 8 years, 142 and 89 patients

2007 Neurosurgery and Psychiatry

837. Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder. (PubMed)

Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder. Idiopathic REM sleep behavior disorder (RBD) is characterized by loss of atonia during REM sleep, resulting in motor activity during dreams. Studies estimate that approximately half of patients with RBD will eventually develop Parkinson disease (PD), so RBD may be an indicator of presymptomatic PD. Several potential early diagnostic markers of PD have been proposed, but they have generally not been tested (...) speed. Autonomic symptoms were more common in patients than controls. Abnormalities were heterogeneous, with some patients scoring normally on all domains, whereas others were severely impaired on multiple domains. Dysfunction on tests of olfactory function, color vision, and motor speed were highly correlated, such that patients who performed poorly on one test tended to perform poorly on the others.Many potential early markers of Parkinson disease are significantly abnormal in idiopathic REM sleep

2006 Neurology

838. Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. (PubMed)

Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. Idiopathic REM sleep behavior disorder (RBD) may represent prodromal synucleinopathies. We report markedly reduced cardiac (123)I-metaiodobenzylguanidine uptake, consistent with the loss of sympathetic terminals, in idiopathic RBD. We also demonstrate that this reduction is of the same magnitude as that found in patients with Parkinson disease. The results are consistent with the hypothesis that idiopathic RBD

2006 Neurology

839. REM sleep behavior disorder, hallucinations, and cognitive impairment in Parkinson's disease. (PubMed)

REM sleep behavior disorder, hallucinations, and cognitive impairment in Parkinson's disease. The objective of this study was to evaluate the relationship between REM sleep behavior disorder (RBD), hallucinations, and cognitive impairment in Parkinson's disease (PD). One hundred and ten PD patients, divided into three groups (without RBD or hallucinations; with RBD but no hallucinations; with RBD and hallucinations), were submitted to neuropsychological evaluation. The group without RBD (...) a longitudinal evaluation.Copyright 2005 Movement Disorder Society.

2006 Movement Disorders

840. Idiopathic REM sleep behavior disorder: toward a better nosologic definition. (PubMed)

Idiopathic REM sleep behavior disorder: toward a better nosologic definition. REM sleep behavior disorder (RBD) is a parasomnia characterized by a lack of motor inhibition during REM sleep leading to potentially harmful dream-enacting behaviors. RBD affects mainly older men and its prevalence in the general population is estimated to be around 0.5%. RBD may be idiopathic or associated with other neurologic disorders. A strong association between RBD and alpha-synucleinopathies has been recently (...) the RBD onset. Recent studies have looked at neurophysiologic and neuropsychological functions in idiopathic RBD and have found evidences of CNS dysfunction during both wakefulness and sleep. An impairment of the cortical activity, specific neuropsychological deficits, and signs of autonomic dysfunction have been observed in a variable proportion of these patients, challenging the concept of idiopathic RBD. Identifying subjects with a high risk of developing a neurodegenerative process may be crucial

2005 Neurology

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