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831 results for

REM Sleep Behavior Disorder

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821. REM sleep behavior disorder is related to striatal monoaminergic deficit in MSA. (PubMed)

REM sleep behavior disorder is related to striatal monoaminergic deficit in MSA. To explore the neurochemical basis of REM sleep behavior disorder (RBD) in multiple-system atrophy (MSA).In 13 patients with probable MSA, nocturnal, laboratory-based polysomnography was used to rate the severity of REM atonia loss by the percentage of REM sleep with tonically increased electromyographic (EMG) activity and the percentage of REM sleep with phasic EMG bursts. PET with (+)-[11C]dihydrotetrabenazine (...) of REM atonia loss (p = 0.003). Thalamic [123I]IBVM binding, however, was not correlated to the severity of REM atonia loss.Decreased nigrostriatal dopaminergic projections may contribute to RBD in MSA.

2003 Neurology

822. Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. (PubMed)

Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. To determine if synucleinopathy pathology is related to REM sleep behavior disorder (RBD) plus dementia or parkinsonism.The clinical and neuropathologic findings were analyzed on all autopsied cases evaluated at Mayo Clinic Rochester from January 1990 to April 2002 who were diagnosed with RBD and a neurodegenerative disorder. Ubiquitin and/or alpha-synuclein immunocytochemistry was used in all cases (...) . The clinical and neuropathologic diagnoses were based on published criteria.Fifteen cases were identified (14 men). All had clear histories of dream enactment behavior, and 10 had RBD confirmed by polysomnography. RBD preceded dementia or parkinsonism in 10 (66.7%) patients by a median of 10 (range 2 to 29) years. The clinical diagnoses included dementia with Lewy bodies (DLB) (n = 6); multiple-system atrophy (MSA) (n = 2); combined DLB, AD, and vascular dementia (n = 1); dementia (n = 1); dementia

2003 Neurology

823. Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD): does the idiopathic form of RBD really exist? (PubMed)

Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD): does the idiopathic form of RBD really exist? To evaluate the cognitive performance of patients with idiopathic REM sleep behavior disorder (RBD).The authors studied 17 consecutive patients with idiopathic RBD vs 17 age- and education-matched control subjects. Tests given to each patient and control included Mini-Mental State Examination, verbal and spatial short-term memory, visual selective attention, verbal

2004 Neurology

824. The effects of pramipexole in REM sleep behavior disorder. (PubMed)

The effects of pramipexole in REM sleep behavior disorder. The authors evaluated the effects of pramipexole, a dopaminergic D2-D3 receptor agonist, on eight patients with idiopathic REM sleep behavior disorder. Five patients reported a sustained reduction in the frequency or intensity of sleep motor behaviors, which was confirmed by video recording, although no change was observed for the percentage of phasic EMG activity during REM sleep. Surprisingly, a decrease in the percentage of time (...) spent with REM sleep muscle atonia was observed with treatment. The treatment did not modify the indexes of periodic leg movements.

2003 Neurology

825. Mirtazapine induces REM sleep behavior disorder (RBD) in parkinsonism. (PubMed)

Mirtazapine induces REM sleep behavior disorder (RBD) in parkinsonism. Shortly after initiation of mirtazapine (a noradrenergic and serotonergic antidepressant) treatment in four patients with parkinsonism, the authors observed the appearance of REM sleep behavior disorder (RBD). In the two patients with severe motor symptoms, RBD was accompanied by hallucinations and confusion. These disturbances resolved with drug discontinuation, and remained resolved by 12- to 24-month follow-up, suggesting

2003 Neurology

826. Visual hallucinations and symptoms of REM sleep behavior disorder in Parkinsonian tauopathies. (PubMed)

Visual hallucinations and symptoms of REM sleep behavior disorder in Parkinsonian tauopathies. In Parkinsonism, visual hallucinations (VH) and REM sleep behavior disorder (RBD) have been thought to indicate underlying synucleinopathy.We tested the validity of this hypothesis by searching for VH and RBD symptoms in Parkinsonism related to tauopathies.Patients with progressive supranuclear palsy or corticobasal degeneration were identified via a clinical data bank.Of 53 patients who expressed

2007 International Journal of Geriatric Psychiatry

827. The REM sleep behavior disorder screening questionnaire-A new diagnostic instrument. (PubMed)

The REM sleep behavior disorder screening questionnaire-A new diagnostic instrument. Many patients with assumed idiopathic REM sleep behavior disorder (RBD) may actually represent an early clinical manifestation of an evolving neurodegenerative disorder, such as the alpha-synucleinopathies, Parkinson's disease or multiple system atrophy. Early detection of these patients is clinically relevant for long-term prospective as well as future neuroprotective studies. For this purpose, we validated (...) ). In most subjects (n = 153) of control group 1, other sleep-wake disturbances were present. The mean RBDSQ score in the RBD group was 9.5 +/- 2.8 points compared with 4.6 +/- 3.0 points in control group 1 (P < 0.0001). Considering an RBDSQ score of five points as a positive test result, we found a sensitivity of 0.96 and a specificity of 0.56. The RBDSQ poorly discriminated patients with the most challenging differential diagnoses such as sleepwalking or epilepsy. In control group 2, the mean RBDSQ

2007 Movement Disorders

828. REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia. (PubMed)

REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia. To assess the relationship between the presence of REM sleep behavior disorder (RBD) and the cognitive profile of nondemented patients with Parkinson disease (PD).Cognitive impairment is an important nonmotor symptom in PD. Waking EEG slowing in nondemented PD has been related to the presence of RBD, a parasomnia affecting brainstem structures and frequently reported in PD. For this reason, RBD may (...) processing compared to both patients with PD without RBD and control subjects. Patients with PD without RBD had no detectable cognitive impairment compared to controls.This study shows that cognitive impairment in nondemented patients with Parkinson disease (PD) is closely related to the presence of REM sleep behavior disorder, a sleep disturbance that was not controlled for in previous studies assessing cognitive deficits in PD.

2007 Neurology

829. Rapid eye movement (REM) sleep behaviour disorder; an easily missed diagnosis, a readily treatable condition. (PubMed)

GABA Modulators 5PE9FDE8GB Clonazepam IM Aged Aged, 80 and over Clonazepam therapeutic use GABA Modulators therapeutic use Humans Male Polysomnography REM Sleep Behavior Disorder diagnosis drug therapy epidemiology physiopathology Risk Factors 2002 7 26 10 0 2002 8 17 10 1 2002 7 26 10 0 ppublish 12137169 PMC2475364 Neurology. 2000 Sep 26;55(6):870-1 10994012 Wien Klin Wochenschr. 2001 Apr 17;113(7-8):249-53 11383385 J Psychiatr Res. 1975 Nov;12(3):189-98 1202204 Brain Pathol. 1999 Oct;9(4):707-20 (...) Rapid eye movement (REM) sleep behaviour disorder; an easily missed diagnosis, a readily treatable condition. 12137169 2002 08 16 2018 11 13 0041-6193 71 1 2002 May The Ulster medical journal Ulster Med J Rapid eye movement (REM) sleep behaviour disorder; an easily missed diagnosis, a readily treatable condition. 62-5 Daly J J JJ Mater Hospital Trust, Department of Psychiatry of Old Age, Belfast. Compton S A SA eng Case Reports Journal Article Northern Ireland Ulster Med J 0417367 0041-6193 0

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2002 The Ulster medical journal

830. Periodic leg movements in REM sleep behavior disorder and related autonomic and EEG activation. (PubMed)

Periodic leg movements in REM sleep behavior disorder and related autonomic and EEG activation. To assess the frequency of periodic leg movements (PLM) in idiopathic REM sleep behavior disorder (RBD) and to analyze their polysomnographic characteristics and associated autonomic and cortical activation.PLM during sleep (PLMS) and wakefulness (PLMW) are typical features of restless legs syndrome (RLS), but are also frequently observed in patients with RBD.Forty patients with idiopathic RBD (...) underwent one night of polysomnographic recording to assess PLMS frequency. PLM features, PLMS-related cardiac activation during stage 2 sleep, and EEG changes were analyzed in 15 of these patients with RBD. Results were compared with similar data obtained in 15 sex- and age-matched patients with primary RLS.Twenty-eight (70%) of 40 patients with RBD showed a PLMS index greater than 10. No between-group differences were found in sleep architecture or indexes of PLMW and PLMS during non-REM sleep

2002 Neurology

831. REM sleep behavior disorder and REM sleep without atonia in Parkinson's disease. (PubMed)

REM sleep behavior disorder and REM sleep without atonia in Parkinson's disease. To determine the frequency of REM sleep behavior disorder (RBD) among patients with PD using both history and polysomnography (PSG) recordings and to further study REM sleep muscle atonia in PD.The reported occurrence of RBD in PD varies from 15 to 47%. However, no study has estimated the frequency of RBD using PSG recordings or analyzed in detail the characteristics of REM sleep muscle atonia in a large group (...) had REM sleep without atonia. Of these 19 patients with PD, 8 (42%) did not present with behavioral manifestations of RBD, and their cases may represent preclinical forms of RBD associated with PD. Moreover, the percentage of time spent with muscle atonia during REM sleep was lower among patients with PD than among healthy control subjects (60.1% vs 93.2%; p = 0.003).RBD and REM sleep without atonia are frequent in PD as shown by PSG recordings.

2002 Neurology

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