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REM Sleep Behavior Disorder

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41. The REM Sleep Behavior Disorder Screening Questionnaire: Validation Study of the Korean Version (RBDQ-KR) (PubMed)

The REM Sleep Behavior Disorder Screening Questionnaire: Validation Study of the Korean Version (RBDQ-KR) REM sleep behavior disorder (RBD) is a parasomnia that is commonly associated with neurodegenerative disorders. We aimed to validate the Hong Kong version of the self-reported RBD questionnaire (RBDQ-HK) with the Korean version (RBDQ-KR) and to investigate its clinical usefulness.One-hundred five patients with RBD and 105 age- and sex-matched controls were enrolled. Thirty were randomly (...) predictive value (89.9%), and negative predictive value (93.1%). Cronbach α coefficient for internal consistency of the total score of the RBDQ-KR was 0.9, which shows high reliability. Exploratory factor analysis showed two components, dream-related and behavioral factors, consistent with the main clinical features of RBD. Based on the results, the best cutoff for the total score ranging from 0 to 100 was at 18/19 and for factor 2 ranging from 0 to 75 was at 11.This study showed RBDQ-KR is a valid

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2017 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

42. Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder (PubMed)

Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder Rapid eye movement (REM) sleep behavior disorder (RBD) is the most specific marker of prodromal alpha-synucleinopathies. We sought to delineate the baseline clinical characteristics of RBD and evaluate risk stratification models.Clinical assessments were performed in 171 RBD, 296 control, and 119 untreated Parkinson's (PD) participants. Putative risk measures were assessed as predictors of prodromal (...) neurodegeneration, and Movement Disorders Society (MDS) criteria for prodromal PD were applied. Participants were screened for common leucine-rich repeat kinase 2 (LRRK2)/glucocerebrosidase gene (GBA) gene mutations.Compared to controls, participants with RBD had higher rates of solvent exposure, head injury, smoking, obesity, and antidepressant use. GBA mutations were more common in RBD, but no LRRK2 mutations were found. RBD participants performed significantly worse than controls on Unified Parkinson's

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2017 Sleep

43. Colonic Oxidative and Mitochondrial Function in Parkinson's Disease and Idiopathic REM Sleep Behavior Disorder (PubMed)

Colonic Oxidative and Mitochondrial Function in Parkinson's Disease and Idiopathic REM Sleep Behavior Disorder To determine potential mitochondrial and oxidative alterations in colon biopsies from idiopathic REM sleep behavior disorder (iRBD) and Parkinson's disease (PD) subjects.Colonic biopsies from 7 iRBD subjects, 9 subjects with clinically diagnosed PD, and 9 healthy controls were homogenized in 5% w/v mannitol. Citrate synthase (CS) and complex I (CI) were analyzed spectrophotometrically

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2017 Parkinson's disease

44. Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism (PubMed)

Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism Rapid eye movement sleep behavior disorder (RBD) is one of the most common non-motor symptoms of parkinsonism, and it may serve as a prodromal marker of neurodegenerative disease. The mechanism underlying RBD is unclear. Several prospective studies have reported that specific non-motor symptoms predict a conversion risk of developing a neurodegenerative disease, including olfactory dysfunction

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2017 Neuroscience bulletin

45. REM Sleep Behavior Disorder Is Not Associated with a More Rapid Cognitive Decline in Mild Dementia (PubMed)

REM Sleep Behavior Disorder Is Not Associated with a More Rapid Cognitive Decline in Mild Dementia REM sleep behavior disorder (RBD) is associated with cognitive dysfunctions and is a risk factor for development of mild cognitive impairment and dementia. However, it is unknown whether RBD is associated with faster cognitive decline in already established dementia. The main goal of this study was to determine if patients with mild dementia with and without RBD differ in progression rate (...) and in specific neuropsychological measures over 4-year follow-up.This longitudinal, prospective study based on data from the DemVest study compares neuropsychological measures in a mild dementia cohort. A diagnosis of probable RBD (pRBD) was made based on the Mayo Sleep Questionnaire. Neuropsychological domains were assessed by Mini Mental State Examination, total score and figure copying, California Verbal Learning Test-II, Visual Object and Space Perception Cube and Silhouettes, Boston Naming Test, Stroop

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2017 Frontiers in neurology

46. MAPT association with REM sleep behavior disorder (PubMed)

MAPT association with REM sleep behavior disorder 28105467 2018 11 13 2376-7839 3 1 2017 Feb Neurology. Genetics Neurol Genet MAPT association with REM sleep behavior disorder. e131 10.1212/NXG.0000000000000131 Fernández-Santiago Rubén R Laboratory of Neurodegenerative Disorders (R.F.-S., M.F., E.T., M.E.), Multidisciplinary Sleep Unit (A.I., C.G., M.S., J.S.), Movement Disorders Unit (E.T.), Department of Neurology, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi (...) i Sunyer (IDIBAPS), University of Barcelona; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) (R.F.-S., A.I., C.G., M.S., M.F., E.T., J.S., M.E.), Madrid; and Movement Disorders Unit (P.P.), Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain. Iranzo Alex A Laboratory of Neurodegenerative Disorders (R.F.-S., M.F., E.T., M.E.), Multidisciplinary Sleep Unit (A.I., C.G., M.S., J.S.), Movement Disorders Unit (E.T.), Department

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2017 Neurology: Genetics

47. REM Sleep Behavior Disorder and Cognitive Impairment in Parkinson’s Disease (PubMed)

REM Sleep Behavior Disorder and Cognitive Impairment in Parkinson’s Disease REM sleep behavior disorder (RBD) is a parasomnia affecting 33% to 46% of patients with Parkinson's disease (PD). The existence of a unique and specific impaired cognitive profile in PD patients with RBD is still controversial. We extensively assessed cognitive functions to identify whether RBD is associated with more severe cognitive deficits in nondemented patients with PD.One hundred sixty-two participants (...) should receive targeted medical attention to better detect and monitor impairment and to enable the development of management interventions for cognitive decline and its consequences.© Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

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2017 Sleep

48. Venlafaxine-induced REM sleep behavioral disorder presenting as two fractures (PubMed)

Venlafaxine-induced REM sleep behavioral disorder presenting as two fractures Rapid eye movement (REM) sleep behavioral disorder is characterized by the absence of muscular atonia during REM sleep. In this disorder, patients can violently act out their dreams, placing them at risk for traumatic fractures during these episodes. REM sleep behavioral disorder (RBD) can be a sign of future neurodegenerative disease and has also been found to be a side effect of certain psychiatric medications. We

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2017 Trauma Case Reports

49. Seeking Good Alternatives to Clonazepam: Suggestions for Future Treatment Trials in REM Sleep Behavior Disorder (PubMed)

Seeking Good Alternatives to Clonazepam: Suggestions for Future Treatment Trials in REM Sleep Behavior Disorder 27448419 2018 08 17 2018 12 02 1550-9397 12 8 2016 08 15 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine J Clin Sleep Med Seeking Good Alternatives to Clonazepam: Suggestions for Future Treatment Trials in REM Sleep Behavior Disorder. 1195-6 10.5664/jcsm.6070 Esaki Yuichi Y Department of Psychiatry, Fujita Health University (...) School of Medicine, Aichi, Japan. Kitajima Tsuyoshi T Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan. eng Letter Research Support, Non-U.S. Gov't Comment 2016 08 15 United States J Clin Sleep Med 101231977 1550-9389 5PE9FDE8GB Clonazepam IM J Clin Sleep Med. 2016 May 15;12(5):689-93 26857053 J Clin Sleep Med. 2016 Aug 15;12(8):1193 27397658 Clonazepam Humans Polysomnography REM Sleep Behavior Disorder Sleep, REM 2016 07 01 2016 07 01 2016 7 25 6 0 2016 7 28 6 0

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2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

50. The Evolution of REM Sleep Behavior Disorder in Early Parkinson Disease (PubMed)

The Evolution of REM Sleep Behavior Disorder in Early Parkinson Disease To investigate the development of REM sleep behavior disorder (RBD) and REM sleep behavioral events (RBE) not yet fulfilling diagnostic criteria for RBD as markers for neurodegeneration in a cohort of Parkinson disease (PD) patients between their de novo baseline assessment and two-year follow-up in comparison to healthy controls (HC).Clinically confirmed PD patients and HC with video-supported polysomnography (vPSG) data (...) at baseline were re-investigated after two years. Diagnostic scoring for RBE and RBD was performed in both groups and related to baseline findings.One hundred thirteen PD patients and 102 healthy controls (HC) were included in the study. Within two years, the overall occurrence of behaviors during REM sleep in PD patients increased from 50% to 63% (P = 0.02). RBD increased from 25% to 43% (P < 0.001). Eleven of 29 (38%) RBE positive PD patients and 10/56 (18%) patients with normal REM sleep at baseline

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2016 Sleep

51. Screening tools for clinical characteristics of probable REM sleep behavior disorder in patients with Parkinson's disease (PubMed)

Screening tools for clinical characteristics of probable REM sleep behavior disorder in patients with Parkinson's disease The REM sleep behavior disorder (RBD) screening questionnaire (RBDSQ) has been used as a screening tool for RBD. We investigated the clinical characteristics of probable RBD (pRBD) using the RBDSQ in patients with Parkinson's disease (PD).Seventy patients with PD (age: 69.2 ± 8.9 years old, 31 males and 49 females, length of PD morbidity: 7.4 ± 6.4 years, Hoehn and Yahr: 2.7

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2016 eNeurologicalSci

52. REM sleep behavior disorder (RBD): Update on diagnosis and treatment (PubMed)

REM sleep behavior disorder (RBD): Update on diagnosis and treatment REM sleep behavior disorder (RBD) is parasomnia characterized by dream enactment and enabled by disruption of physiological muscle atonia during REM sleep. Over the past few years, diagnostic criteria and the methods used to confirm diagnosis have been updated.In this review article, the current knowledge regarding RBD diagnosis and treatment is presented.A selective literature search was carried out.Although several RBD (...) screening questionnaires have been developed, diagnosis can only be definitely confirmed on the basis of polysomnography. New methods for scoring electromyography (EMG) activity during REM sleep have been proposed during recent years and cutoff values have been established. The latest cutoff values for scoring EMG activity during REM sleep are included in the International Classification of Sleep Disorders (ICSD). The cutoff of 27 % muscle activity during REM sleep suggested by the Sleep Innsbruck

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2016 Somnologie

53. Effects of Rotigotine on REM Sleep Behavior Disorder in Parkinson Disease (PubMed)

Effects of Rotigotine on REM Sleep Behavior Disorder in Parkinson Disease REM sleep behavior disorder (RBD) is a common manifestation of Parkinson disease (PD). In this study, we assessed the effects of rotigotine transdermal patch on RBD features in patients with PD.In this prospective open-label study, eleven PD patients with untreated RBD were administered rotigotine patches for up to seven months to ameliorate their parkinsonism. The severities of their RBD symptoms before and after (...) rotigotine therapy were evaluated through patient and bed partner interviews, a validated evaluation scale (REM sleep behavior disorder questionnaire-Hong Kong, RBDQ-HK), and blinded assessments based on video-polysomnographic (VPSG) measure.Rotigotine improved parkinsonism and subjective sleep quality in PD patients with RBD. The RBDQ-HK total score, especially the Factor 2 score, was decreased, which demonstrated that the subjective severity of RBD symptoms was improved after rotigotine treatment

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2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

54. Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder

Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02871427 Recruitment Status : Active, not recruiting First Posted

2016 Clinical Trials

55. Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder

Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02984137 Recruitment Status : Active, not recruiting First Posted : December 6, 2016 Last Update Posted : April 17, 2018 Sponsor: Seoul National University Hospital

2016 Clinical Trials

56. Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD)

Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD) Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02708186 Recruitment Status : Completed First Posted : March 15, 2016

2016 Clinical Trials

57. Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep Behavior Disorder

Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep Behavior Disorder Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep Behavior Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep Behavior Disorder (MP-TCSP-IRMf) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02824341

2016 Clinical Trials

58. Idiopathic REM sleep behavior disorder and neurodegenerative risk: To tell or not to tell to the patient? How to minimize the risk? (PubMed)

Idiopathic REM sleep behavior disorder and neurodegenerative risk: To tell or not to tell to the patient? How to minimize the risk? Most people with idiopathic REM sleep behavior disorder (iRBD) have an underlying synucleinopathy, mainly Parkinson's disease (PD) or dementia with Lewy bodies, with median conversion time of 4-9 y from iRBD diagnosis and of 11-16 y from symptom onset. Subtle signs and imaging tests indicate concomitant neurodegeneration in widespread brain areas. Risk factor (...) studies suggest that iRBD patients may have prior head injury, occupational farming, pesticide exposure, low education level and possibly more frequent family history of dream-enactment behavior (but not of PD), plus unexpected risk factors (smoking, ischemic heart disease and inhaled corticosteroid use). Unlike PD, caffeine and smoking appear not to have a protective role. Prior depression and antidepressant use may be early neurodegenerative signs rather than exclusively causative factors. Age

2016 Sleep medicine reviews

59. The role of the melanoma gene MC1R in Parkinson disease and REM sleep behavior disorder. (PubMed)

The role of the melanoma gene MC1R in Parkinson disease and REM sleep behavior disorder. The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n = 539) and controls (n = 265) from New York, and PD patients (n = 551), rapid eye movement sleep behavior disorder (RBD) patients (n = 351), and controls (n = 956) of European ancestry. Sixty-eight MC1R variants were identified, including 7 common variants with frequency > 0.01. None of the common

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2016 Neurobiology of Aging

60. Depressed REM Sleep Behavior Disorder Patients Are Less Likely to Recall Enacted Dreams than Non-Depressed Ones (PubMed)

Depressed REM Sleep Behavior Disorder Patients Are Less Likely to Recall Enacted Dreams than Non-Depressed Ones REM sleep behavior disorder (RBD) is associated with psychiatric symptoms, such as anxiety and alexithymia. However, only a few studies on the relationship between depression and RBD have been published. In this study, we investigated the occurrence of depression and associated factors in patients with RBD.In total 94 patients (mean age: 61.9±12.7 years, male: 70.2%) diagnosed as RBD (...) with depression, after controlling for confounding variables including the respiratory disturbance index and a history of psychiatric disorders (odds ratio=0.323, p=0.041).In this study, 44.7% of RBD patients were found to suffer from depressed mood. And, depression was found to be associated with reduced ability to recall enacted dreams. We suggest that routine evaluation of depression be performed in RBD patients, particularly when failure to recall enacted dreams is evident. We speculate that such failure

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2016 Psychiatry investigation

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