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REM Sleep Behavior Disorder

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41. Prevalence of obstructive sleep apnoea in REM behaviour disorder: response to continuous positive airway pressure therapy Full Text available with Trip Pro

Prevalence of obstructive sleep apnoea in REM behaviour disorder: response to continuous positive airway pressure therapy Rapid eye movement behaviour disorder (RBD) is a parasomnia in which there is loss of muscle atonia during rapid eye movement (REM) sleep, resulting in dream enactment. The aims of this study were to determine the prevalence of obstructive sleep apnoea (OSA) in RBD patients and determine whether continuous positive airway pressure (CPAP) therapy improved RBD symptoms (...) in patients with concomitant RBD and OSA.A questionnaire was mailed to 120 patients identified from a tertiary sleep centre with RBD meeting full International Classification for Sleep Disorders-3 (ICSD-3) criteria. Patients were diagnosed as having OSA if they had an apnoea-hypopnea index (AHI) ≥ 5. The questionnaire focused on CPAP-use, compliance and complications. Standard statistical analysis was undertaken using SPSS (v.21, IBM).One hundred and seven of the potential participants (89.2%) had an OSA

2017 Sleep & breathing = Schlaf & Atmung

42. REM sleep respiratory behaviours match mental content in narcoleptic lucid dreamers Full Text available with Trip Pro

REM sleep respiratory behaviours match mental content in narcoleptic lucid dreamers Breathing is irregular during rapid eye-movement (REM) sleep, whereas it is stable during non-REM sleep. Why this is so remains a mystery. We propose that irregular breathing has a cortical origin and reflects the mental content of dreams, which often accompany REM sleep. We tested 21 patients with narcolepsy who had the exceptional ability to lucid dream in REM sleep, a condition in which one is conscious (...) water) and the observed respiratory behaviour (e.g., central apnoea) and, in several cases, a preparatory breath before the respiratory behaviour. This suggests that the cortico-subcortical networks involved in voluntary respiratory movements are preserved during REM sleep and that breathing irregularities during this stage have a cortical/subcortical origin that reflects dream content.

2018 Scientific reports

43. The REM Sleep Behavior Disorder Screening Questionnaire: Validation Study of the Korean Version (RBDQ-KR) Full Text available with Trip Pro

The REM Sleep Behavior Disorder Screening Questionnaire: Validation Study of the Korean Version (RBDQ-KR) REM sleep behavior disorder (RBD) is a parasomnia that is commonly associated with neurodegenerative disorders. We aimed to validate the Hong Kong version of the self-reported RBD questionnaire (RBDQ-HK) with the Korean version (RBDQ-KR) and to investigate its clinical usefulness.One-hundred five patients with RBD and 105 age- and sex-matched controls were enrolled. Thirty were randomly (...) predictive value (89.9%), and negative predictive value (93.1%). Cronbach α coefficient for internal consistency of the total score of the RBDQ-KR was 0.9, which shows high reliability. Exploratory factor analysis showed two components, dream-related and behavioral factors, consistent with the main clinical features of RBD. Based on the results, the best cutoff for the total score ranging from 0 to 100 was at 18/19 and for factor 2 ranging from 0 to 75 was at 11.This study showed RBDQ-KR is a valid

2017 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

44. Probable REM-Sleep Behavior Disorder and Dysautonomic Symptoms in Essential Tremor Full Text available with Trip Pro

Probable REM-Sleep Behavior Disorder and Dysautonomic Symptoms in Essential Tremor Non-motor symptoms can be present in essential tremor (ET). We intend to assess the frequency of rapid eye movement (REM) sleep behavior disorder (RBD) and dysautonomic symptoms in ET patients and evaluate the differences between patients with ET and RBD (ET-RBD and ET without RBD [ET-nonRBD]).All ET patients were contacted by telephone. Autonomic symptoms were assessed using the Scales for Outcomes (...) in Parkinson's Disease-Autonomic (SCOPA-AUT) questionnaire, and RBD symptoms with the RBD screening questionnaire (RBDSQ) using ≥5 as a cut-off for probable RBD (pRBD).From 92 ET patients contacted, 53 (55% female) were included. The mean age at assessment was 73.6±19 years, and the average disease duration was 19.9±17.3 years. Fourteen patients (26.4%) had pRBD and 52 (98.1%) reported at least one autonomic symptom, the most prevalent being urinary symptoms (96%). The ET-RBD group had higher SCOPA-total

2017 Tremor and Other Hyperkinetic Movements

45. Loss of Substantia Nigra Hyperintensity at 3.0-T MR Imaging in Idiopathic REM Sleep Behavior Disorder: Comparison with <sup>123</sup>I-FP-CIT SPECT. Full Text available with Trip Pro

Loss of Substantia Nigra Hyperintensity at 3.0-T MR Imaging in Idiopathic REM Sleep Behavior Disorder: Comparison with 123I-FP-CIT SPECT. Purpose To examine whether the loss of nigral hyperintensity (NH) on 3.0-T susceptibility-weighted (SW) magnetic resonance (MR) images can help identify high synucleinopathy risk in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD). Materials and Methods Between March 2014 and April 2015, 18 consecutively recruited patients (...) with iRBD were evaluated with 3.0-T SW imaging and iodine 123-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) single photon emission computed tomography and compared with 18 healthy subjects and 18 patients with Parkinson disease (PD). Two readers blinded to clinical diagnosis independently assessed the images. 123I-FP-CIT uptake ratios were compared by using the Kruskal-Wallis test, and intra- and interobserver agreements were assessed with the Cohen κ. The synucleinopathy

2017 Radiology

46. Dopamine transporter imaging deficit predicts early transition to synucleinopathy in idiopathic REM sleep behavior disorder. (Abstract)

Dopamine transporter imaging deficit predicts early transition to synucleinopathy in idiopathic REM sleep behavior disorder. To determine the usefulness of dopamine transporter (DAT) imaging to identify idiopathic rapid eye movement sleep behavior disorder (IRBD) patients at risk for short-term development of clinically defined synucleinopathy.Eighty-seven patients with polysomnography-confirmed IRBD underwent 123 I-FP-CIT DAT-SPECT. Results were compared to 20 matched controls without RBD who (...) underwent DAT-SPECT. In patients, FP-CIT uptake was considered abnormal when values were two standard deviations below controls' mean uptake. After DAT-SPECT, patients were followed up during 5.7 ± 2.2 (range, 2.6-9.9) years.Baseline DAT deficit was found in 51 (58.6%) patients. During follow-up, 25 (28.7%) subjects developed clinically defined synucleinopathy (Parkinson's disease in 11, dementia with Lewy bodies in 13, and multiple system atrophy in 1) with mean latency of 3.2 ± 1.9 years from imaging

2017 Annals of Neurology

47. FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder. Full Text available with Trip Pro

FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder. Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD-related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD-related pattern, dopamine transporter (...) binding, and olfaction in idiopathic REM sleep behavior disorder.In this cross-sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent 18 F-fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing. For reference, we included 18 F-fluorodeoxyglucose PET data of 19 controls, 20 PD patients, and 22 patients with dementia with Lewy bodies. PD-related pattern expression z-scores were computed from all PET scans.PD-related pattern expression was higher in idiopathic

2017 Movement Disorders

48. REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions. Full Text available with Trip Pro

REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions. Rapid eye movement sleep behavior disorder (RBD) is diagnosed by a clinical history of dream enactment accompanied by polysomnographic rapid eye movement sleep atonia loss (rapid eye movement sleep without atonia). Rapid eye movement sleep behavior disorder is strongly associated with neurodegenerative disease, especially synucleinopathies such as Parkinson disease, dementia with Lewy bodies, and multiple (...) , and autonomic tests. Up to 90.9% of patients with idiopathic RBD ultimately develop a defined neurodegenerative disease over longitudinal follow-up, although the prognosis for younger patients and antidepressant-associated RBD is less clear. Patients with RBD should be treated with either melatonin 3 to 12 mg or clonazepam 0.5 to 2.0 mg to reduce injury potential. Prospective outcome and treatment studies of RBD are necessary to enable accurate prognosis and better evidence for symptomatic therapy

2017 Mayo Clinic Proceedings

49. Venlafaxine-induced REM sleep behavioral disorder presenting as two fractures Full Text available with Trip Pro

Venlafaxine-induced REM sleep behavioral disorder presenting as two fractures Rapid eye movement (REM) sleep behavioral disorder is characterized by the absence of muscular atonia during REM sleep. In this disorder, patients can violently act out their dreams, placing them at risk for traumatic fractures during these episodes. REM sleep behavioral disorder (RBD) can be a sign of future neurodegenerative disease and has also been found to be a side effect of certain psychiatric medications. We

2017 Trauma Case Reports

50. Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism Full Text available with Trip Pro

Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism Rapid eye movement sleep behavior disorder (RBD) is one of the most common non-motor symptoms of parkinsonism, and it may serve as a prodromal marker of neurodegenerative disease. The mechanism underlying RBD is unclear. Several prospective studies have reported that specific non-motor symptoms predict a conversion risk of developing a neurodegenerative disease, including olfactory dysfunction (...) , abnormal color vision, autonomic dysfunction, excessive daytime sleepiness, depression, and cognitive impairment. Parkinson's disease (PD) with RBD exhibits clinical heterogeneity with respect to motor and non-motor symptoms compared with PD without RBD. In this review, we describe the main clinical and pathogenic features of RBD, focusing on its association with other non-motor symptoms of parkinsonism.

2017 Neuroscience bulletin

51. REM Sleep Behavior Disorder Is Not Associated with a More Rapid Cognitive Decline in Mild Dementia Full Text available with Trip Pro

REM Sleep Behavior Disorder Is Not Associated with a More Rapid Cognitive Decline in Mild Dementia REM sleep behavior disorder (RBD) is associated with cognitive dysfunctions and is a risk factor for development of mild cognitive impairment and dementia. However, it is unknown whether RBD is associated with faster cognitive decline in already established dementia. The main goal of this study was to determine if patients with mild dementia with and without RBD differ in progression rate (...) and in specific neuropsychological measures over 4-year follow-up.This longitudinal, prospective study based on data from the DemVest study compares neuropsychological measures in a mild dementia cohort. A diagnosis of probable RBD (pRBD) was made based on the Mayo Sleep Questionnaire. Neuropsychological domains were assessed by Mini Mental State Examination, total score and figure copying, California Verbal Learning Test-II, Visual Object and Space Perception Cube and Silhouettes, Boston Naming Test, Stroop

2017 Frontiers in neurology

52. Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder Full Text available with Trip Pro

Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder Rapid eye movement (REM) sleep behavior disorder (RBD) is the most specific marker of prodromal alpha-synucleinopathies. We sought to delineate the baseline clinical characteristics of RBD and evaluate risk stratification models.Clinical assessments were performed in 171 RBD, 296 control, and 119 untreated Parkinson's (PD) participants. Putative risk measures were assessed as predictors of prodromal (...) Disease Rating Scale (UPDRS)-III, timed "get-up-and-go", Flamingo test, Sniffin Sticks, and cognitive tests and had worse measures of constipation, quality of life (QOL), and orthostatic hypotension. For all these measures except UPDRS-III, RBD and PD participants were equally impaired. Depression, anxiety, and apathy were worse in RBD compared to PD participants. Stratification of people with RBD according to antidepressant use, obesity, and age altered the odds ratio (OR) of hyposmia compared

2017 Sleep

53. MAPT association with REM sleep behavior disorder Full Text available with Trip Pro

MAPT association with REM sleep behavior disorder 28105467 2018 11 13 2376-7839 3 1 2017 Feb Neurology. Genetics Neurol Genet MAPT association with REM sleep behavior disorder. e131 10.1212/NXG.0000000000000131 Fernández-Santiago Rubén R Laboratory of Neurodegenerative Disorders (R.F.-S., M.F., E.T., M.E.), Multidisciplinary Sleep Unit (A.I., C.G., M.S., J.S.), Movement Disorders Unit (E.T.), Department of Neurology, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi (...) i Sunyer (IDIBAPS), University of Barcelona; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) (R.F.-S., A.I., C.G., M.S., M.F., E.T., J.S., M.E.), Madrid; and Movement Disorders Unit (P.P.), Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain. Iranzo Alex A Laboratory of Neurodegenerative Disorders (R.F.-S., M.F., E.T., M.E.), Multidisciplinary Sleep Unit (A.I., C.G., M.S., J.S.), Movement Disorders Unit (E.T.), Department

2017 Neurology: Genetics

54. Brain Imaging in the Idiopathic REM Sleep Behavior Disorder (ALICE)

and compared the results with those from 21 age- and gender-matched healthy volunteers. All subjects will undergo a clinical examination, motor, cognitive, autonomous, psychological, olfactory and color vision tests, and rapid eye movement sleep characterization using video-polysomnography and 3 T magnetic resonance imaging. Condition or disease Intervention/treatment REM Sleep Behavior Disorder Healthy Other: Clinical investigations Study Design Go to Layout table for study information Study Type (...) le Sommeil Collaborators: NRJ Foundation - Institute of France National Research Agency, France Information provided by (Responsible Party): Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil Study Details Study Description Go to Brief Summary: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is characterized by nocturnal violence, increased muscle tone during REM sleep and the lack of any other neurological disease. However, iRBD can

2017 Clinical Trials

55. Characterization of patients with longstanding idiopathic REM sleep behavior disorder. (Abstract)

Characterization of patients with longstanding idiopathic REM sleep behavior disorder. To evaluate the presence of prodromal markers of Parkinson disease (PD) in patients with longstanding idiopathic REM sleep behavior disorder (IRBD), a small subgroup of individuals with IRBD with long-term follow-up thought not to be at risk of developing PD.Demographic, clinical, and neuroimaging markers of PD were evaluated in 20 patients with polysomnographic-confirmed longstanding IRBD and in 32 matched (...) controls.Patients were 16 men and 4 women with mean age of 72.9 ± 8.6 years and mean follow-up from IRBD diagnosis of 12.1 ± 2.6 years. Patients more often had objective smell loss (35% vs 3.4%, p = 0.003), constipation (50% vs 15.6%, p = 0.008), and mild parkinsonian signs (45% vs 18.8%, p = 0.042) than controls. Unified Parkinson's Disease Rating Scale motor score was higher in patients than in controls (5.6 ± 3.5 vs 2.0 ± 2.1, p < 0.0001). Dopamine transporter imaging showed decreased striatal uptake in 82.4

2017 Neurology

56. Probable REM sleep behavior disorder and risk of stroke: A prospective study. Full Text available with Trip Pro

Probable REM sleep behavior disorder and risk of stroke: A prospective study. To examine whether probable REM sleep behavior disorder (pRBD) was associated with increased risk of developing stroke in a community-based cohort.The study included 12,003 participants (mean age 54.0 years) of the Kailuan Study, free of stroke, cancer, Parkinson disease, dementia, and head injury at baseline (2012). We determined pRBD using a validated REM sleep behavior disorder (RBD) questionnaire in 2012. Incident (...) stroke cases were confirmed by review of medical records. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of stroke according to pRBD status, adjusting for several sleep measures (i.e., insomnia, daytime sleepiness, sleep duration, snoring, and use of hypnotics) and other potential confounders.During 3 years of follow-up, we documented 159 incident stroke cases. Relative to participants without pRBD at the baseline, those with pRBD had a 157

2017 Neurology

57. Skin nerve phosphorylated α-synuclein deposits in idiopathic REM sleep behavior disorder. (Abstract)

Skin nerve phosphorylated α-synuclein deposits in idiopathic REM sleep behavior disorder. To test if phosphorylated α-synuclein (p-α-syn) deposits can be detected by means of skin biopsy in patients with idiopathic REM sleep behavior disorder (iRBD) as a potential early histopathologic marker of impending synucleinopathy.Proximal (cervical) and distal (legs) samples of skin biopsy were obtained from 12 patients with polysomnographically confirmed iRBD and 55 sex- and age-matched healthy

2017 Neurology

58. Increased Motor Activity During REM Sleep Is Linked with Dopamine Function in Idiopathic REM Sleep Behavior Disorder and Parkinson Disease Full Text available with Trip Pro

Increased Motor Activity During REM Sleep Is Linked with Dopamine Function in Idiopathic REM Sleep Behavior Disorder and Parkinson Disease Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by impaired motor inhibition during REM sleep, and dream-enacting behavior. RBD is especially associated with α-synucleinopathies, such as Parkinson disease (PD). Follow-up studies have shown that patients with idiopathic RBD (iRBD) have an increased risk of developing an α (...) -synucleinopathy in later life. Although abundant studies have shown that degeneration of the nigrostriatal dopaminergic system is associated with daytime motor function in Parkinson disease, only few studies have investigated the relation between this system and electromyographic (EMG) activity during sleep. The objective of this study was to investigate the relationship between the nigrostriatal dopamine system and muscle activity during sleep in iRBD and PD.10 iRBD patients, 10 PD patients with PD, 10 PD

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

59. Diagnostic REM Sleep Muscle Activity Thresholds in Idiopathic REM Sleep Behavior Disorder Patients with and without Obstructive Sleep Apnea Full Text available with Trip Pro

provides evidence for quantitative RSWA diagnostic thresholds applicable in iRBD patients with OSA. Our findings in this study were very similar to those seen in patients with Parkinson's disease-REM sleep behavior disorder (PD-RBD), consistent with a common mechanism and presumed underlying etiology of synucleinopathy in both groups.Copyright © 2016 Elsevier B.V. All rights reserved. (...) Diagnostic REM Sleep Muscle Activity Thresholds in Idiopathic REM Sleep Behavior Disorder Patients with and without Obstructive Sleep Apnea We aimed to determine whether visual and automated rapid eye movement (REM) sleep without atonia (RSWA) methods could accurately diagnose patients with idiopathic REM sleep behavior disorder (iRBD) and comorbid obstructive sleep apnea (OSA).In iRBD patients (n = 15) and matched controls (n = 30) with and without OSA, we visually analyzed RSWA phasic burst

2016 Sleep medicine

60. REM Sleep Behavior Disorder

) Definition (MSH) A disorder characterized by episodes of vigorous and often violent motor activity during REM sleep (SLEEP, REM). The affected individual may inflict self injury or harm others, and is difficult to awaken from this condition. Episodes are usually followed by a vivid recollection of a dream that is consistent with the aggressive behavior. This condition primarily affects adult males. (From Adams et al., Principles of Neurology, 6th ed, p393) Concepts Disease or Syndrome ( T047 ) MSH ICD9 (...) Sleep Behavior Disorder , REM sleep behavior dis , REM Sleep Behavior Disorder [Disease/Finding] , rem sleep behavior disorder , rem behavior sleep disorder , behavior disorders rem sleep , rem behavior disorder , REM sleep behavior disorder (diagnosis) , sleep disorder rem sleep behavior , REM sleep behavior disorder , REM sleep behaviour disorder , REM sleep disorder , Rapid eye movement sleep behavior disorder (disorder) , Rapid eye movement sleep behavior disorder , Rapid eye movement sleep

2018 FP Notebook

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