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REM Sleep Behavior Disorder

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21. Novel biomarker signatures for idiopathic REM sleep behavior disorder: A proteomic and system biology approach. (Abstract)

Novel biomarker signatures for idiopathic REM sleep behavior disorder: A proteomic and system biology approach. To perform a rigorous in-depth proteomics analysis to identify circulating biomarker signatures for idiopathic REM sleep behavior disorder (RBD), capable of providing new insights into the underlying pathogenic mechanisms and putative α-synuclein-related neurodegenerative processes.Serum samples from patients with idiopathic RBD (n = 9) and healthy controls (n = 10) were subjected (...) into new therapeutic strategies with disease-modifying effects. Further evaluation of the identified markers is required to confirm their diagnostic value and potential to guide clinical decision-making.© 2018 American Academy of Neurology.

2018 Neurology

22. Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD. Full Text available with Trip Pro

Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD. We sought to identify motor features that would allow the delineation of individuals with sleep study-confirmed idiopathic REM sleep behavior disorder (iRBD) from controls and Parkinson disease (PD) using a customized smartphone application.A total of 334 PD, 104 iRBD, and 84 control participants performed 7 tasks to evaluate voice, balance, gait, finger tapping, reaction time, rest tremor (...) . For the 3 pairwise discriminatory comparisons, (1) controls vs iRBD, (2) controls vs PD, and (3) iRBD vs PD, the mean sensitivity and specificity values ranged from 84.6% to 91.9%. Postural tremor, rest tremor, and voice were the most discriminatory tasks overall, whereas the reaction time was least discriminatory.Prodromal forms of PD include the sleep disorder iRBD, where subtle motor impairment can be detected using clinician-based rating scales (e.g., Unified Parkinson's Disease Rating Scale), which

2018 Neurology

23. REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB) Full Text available with Trip Pro

REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB) Rapid eye movement sleep behavior disorder (RBD) is a parasomnia, with abnormal dream-enacting behavior during the rapid eye movement (REM) sleep. RBD is either idiopathic or secondary to other neurologic disorders and medications. Dementia with Lewy bodies (DLB) is the third most common cause of dementia, and the typical clinical presentation is rapidly progressive cognitive impairment. RBD is one of the core features of DLB

2018 Behavioural neurology

24. Screening for idiopathic REM sleep behavior disorder: usefulness of actigraphy Full Text available with Trip Pro

Screening for idiopathic REM sleep behavior disorder: usefulness of actigraphy To evaluate the utility of multimodal low-cost approaches including actigraphy, a wrist-worn device monitoring rest/activity cycles, in identifying patients with idiopathic REM sleep behavior disorder (iRBD).Seventy patients diagnosed with sleep disorders causing different motor manifestations during sleep (iRBD, sleep apnea, restless legs syndrome) and 20 subjects without any relevant motor manifestation during (...) analysis of actigraphy using pattern recognition can identify subjects with iRBD, and is able to distinguish iRBD from other motor activities during sleep, even when patients are not aware of the disease in contrast to questionnaires. Therefore, actigraphy can be a reliable screening instrument for RBD potentially useful in the general population.

2018 Sleep

25. Deterioration of executive dysfunction in elderly with REM sleep behavior disorder (RBD). (Abstract)

Deterioration of executive dysfunction in elderly with REM sleep behavior disorder (RBD). REM sleep behavior disorder (RBD) represents a major and relatively specific prodromal marker for synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies, and multisystem atrophy. Because PD patients primarily suffer from executive dysfunction, we hypothesized that individuals with RBD show an impairment in the nonamnestic executive domain rather than in amnestic domains. To address (...) this question, we investigated a cohort of 1145 healthy elderly (183 with RBD) cross-sectionally and a subgroup of 544 of them longitudinally (144 with RBD) over 6 years. Assessments included the RBD screening questionnaire, the extended Consortium to Establish a Registry for Alzheimer's Disease test battery, and genetic testing for the risk variant rs356219 in the alpha-synuclein gene. In the cross-sectional analysis, the RBD subgroup showed worse performance in the Trail Making Test (TMT) part B

2018 Neurobiology of Aging

26. Cortical and subcortical gray matter bases of cognitive deficits in REM sleep behavior disorder. Full Text available with Trip Pro

Cortical and subcortical gray matter bases of cognitive deficits in REM sleep behavior disorder. To investigate cortical and subcortical gray matter abnormalities underlying cognitive impairment in patients with REM sleep behavior disorder (RBD) with or without mild cognitive impairment (MCI).Fifty-two patients with RBD, including 17 patients with MCI, were recruited and compared to 41 controls. All participants underwent extensive clinical assessments, neuropsychological examination, and 3

2018 Neurology

27. How does dementia with Lewy bodies start? Prodromal cognitive changes in REM sleep behavior disorder. (Abstract)

How does dementia with Lewy bodies start? Prodromal cognitive changes in REM sleep behavior disorder. We describe the progression of cognitive decline and identify the predictive values of cognitive tests in three groups of REM sleep behavior disorder (RBD) patients classified at their last follow-up as having Parkinson's disease (PD), dementia with Lewy bodies (DLB), or still-idiopathic.Patients (n = 109) underwent polysomnographic, neurological, and neuropsychological assessments. We used (...) of cognitive tests to predict dementia.At follow-up, 38 patients (35%) developed a neurodegenerative disorder: 20 had PD and 18 DLB. Cognitive performance changes over time were strongly associated with later development of dementia. Clear deficits in attention and executive functions were observed 6 years before diagnosis. Verbal episodic learning and memory deficits started later, deviating from normal approximately 5 to 6 years and becoming clinically impaired at 1 to 2 years before diagnosis

2018 Annals of Neurology

28. Establish a National Registry of REM Sleep Behavior Disorder

of Hong Kong Information provided by (Responsible Party): Dr. Zhang Jihui, Chinese University of Hong Kong Study Details Study Description Go to Brief Summary: In this proposed study, the investigators aim to build up a large cohort of Rapid eye movement sleep behavior disorder (RBD) to study the etiology and risk factors of neurodegeneration. Condition or disease REM Sleep Behavior Disorder Detailed Description: REM sleep behavior disorder (RBD) is a parasomnia characterized by abnormal behavioral (...) brain pathology. 3) No narcolepsy or hypersomnia, ruled out by multiple sleep latency test. 4) No history of mental illnesses or use of antidepressants Outcome Measures Go to Primary Outcome Measures : Risk factors for neurodegenerative diseases in rapid eye movement sleep behavior disorder. [ Time Frame: 1 hour ] Risk factors for neurodegenerative diseases were investigated in rapid eye movement sleep behavior disorder by questionnaires, including general information, life history, occupational

2018 Clinical Trials

29. Vestibular Evoked Myogenic Potentials Are Abnormal in Idiopathic REM Sleep Behavior Disorder Full Text available with Trip Pro

Vestibular Evoked Myogenic Potentials Are Abnormal in Idiopathic REM Sleep Behavior Disorder Objectives: To investigate brainstem function in idiopathic REM sleep Behavior Disorder (iRBD), a condition occurring as a result of a derangement of connections within brainstem structures, with a battery of Vestibular Evoked Myogenic Potentials (VEMPs), neurophysiological tools suited for the functional investigation of the brainstem. Neurophysiological data were correlated with clinical

2018 Frontiers in neurology

30. Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder

Verified: February 2018 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by University Hospital, Clermont-Ferrand: functional MRI Reward system REM sleep behaviour disorder Narco-cataplexy Additional relevant MeSH terms: Layout table for MeSH terms Mental Disorders Narcolepsy REM Sleep Behavior Disorder Cataplexy Disorders of Excessive Somnolence Sleep Disorders, Intrinsic Dyssomnias Sleep Wake (...) Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2018 Clinical Trials

31. Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease. Full Text available with Trip Pro

Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease. Phosphorylated alpha-synuclein (p-alpha-syn) deposits, one of the neuropathological hallmarks of Parkinson's disease (PD), have recently been detected in dermal nerve fibres in PD patients with good specificity and sensitivity. Here, we studied whether p-alpha-syn may serve as a biomarker in patients with a high risk of developing PD, such as those with REM sleep behaviour disorder (...) on published research criteria. Skin serial sections were assessed by double-immunofluorescence labelling with antibodies to pSer129-alpha-syn under blinded conditions. P-alpha-syn was visualized in 10/18 patients with RBD (sensitivity of 55.6%) and in 20/25 early PD patients (sensitivity of 80%) but in none of the controls (specificity of 100%). The percentage of dermal structures innervated by p-alpha-syn-positive fibres was negatively correlated with dopamine transporter binding in the FP-CIT-SPECT (ρ

2017 Acta neuropathologica

32. Sleep in REM sleep behavior disorder: a systematic review and meta-analysis of polysomnographic findings

Sleep in REM sleep behavior disorder: a systematic review and meta-analysis of polysomnographic findings Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files (...) cell dose (linear); blinding of outcome assessment reported (stratified yes vs no). For stratified analyses, a minimum number of 8 studies per subgroup is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome

2019 PROSPERO

33. Family history of REM sleep behaviour disorder more common in individuals affected by the disorder than among unaffected individuals

iRBD were present. People with iRBD met International Classification of Sleep Disorders criteria of having enhanced REM muscle tone on a polysomnogram, with a history of dream-enactment or complex behaviours during REM sleep. Controls included those with other sleep conditions (n=206) and those without sleep disorders (n=110). The absence of RBD was confirmed by a polysomnogram for all controls with other sleep conditions and 41 controls without sleep disorders. Setting: Twelve international RBD (...) Family history of REM sleep behaviour disorder more common in individuals affected by the disorder than among unaffected individuals Family history of REM sleep behaviour disorder more common in individuals affected by the disorder than among unaffected individuals | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please

2013 Evidence-Based Mental Health

34. REM sleep behavior disorder is related to enteric neuropathology in Parkinson disease. (Abstract)

REM sleep behavior disorder is related to enteric neuropathology in Parkinson disease. To determine whether REM sleep behavior disorder (RBD) in Parkinson disease (PD) is associated with lesions and dysfunctions of the autonomic nervous system by evaluating enteric phosphorylated α-synuclein histopathology (PASH) and permeability.A total of 45 patients with PD were included in this cross-sectional study. RBD was diagnosed on the basis of a standardized clinical interview and confirmed

2017 Neurology

35. REM Sleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies. (Abstract)

REM Sleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies. Rapid eye movement sleep behavior disorder is characterized by dream enactment and complex motor behaviors during rapid eye movement sleep and rapid eye movement sleep atonia loss (rapid eye movement sleep without atonia) during polysomnography. Rapid eye movement sleep behavior disorder may be idiopathic or symptomatic and in both settings is highly associated with synucleinopathy neurodegeneration, especially (...) Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and pure autonomic failure. Rapid eye movement sleep behavior disorder frequently manifests years to decades prior to overt motor, cognitive, or autonomic impairments as the presenting manifestation of synucleinopathy, along with other subtler prodromal "soft" signs of hyposmia, constipation, and orthostatic hypotension. Between 35% and 91.9% of patients initially diagnosed with idiopathic rapid eye movement sleep behavior disorder

2017 Movement Disorders

36. Colonic Oxidative and Mitochondrial Function in Parkinson's Disease and Idiopathic REM Sleep Behavior Disorder Full Text available with Trip Pro

Colonic Oxidative and Mitochondrial Function in Parkinson's Disease and Idiopathic REM Sleep Behavior Disorder To determine potential mitochondrial and oxidative alterations in colon biopsies from idiopathic REM sleep behavior disorder (iRBD) and Parkinson's disease (PD) subjects.Colonic biopsies from 7 iRBD subjects, 9 subjects with clinically diagnosed PD, and 9 healthy controls were homogenized in 5% w/v mannitol. Citrate synthase (CS) and complex I (CI) were analyzed spectrophotometrically

2017 Parkinson's disease

37. REM Sleep Behavior Disorder and Cognitive Impairment in Parkinson’s Disease Full Text available with Trip Pro

REM Sleep Behavior Disorder and Cognitive Impairment in Parkinson’s Disease REM sleep behavior disorder (RBD) is a parasomnia affecting 33% to 46% of patients with Parkinson's disease (PD). The existence of a unique and specific impaired cognitive profile in PD patients with RBD is still controversial. We extensively assessed cognitive functions to identify whether RBD is associated with more severe cognitive deficits in nondemented patients with PD.One hundred sixty-two participants (...) should receive targeted medical attention to better detect and monitor impairment and to enable the development of management interventions for cognitive decline and its consequences.© Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

2017 Sleep

38. Validation of the MDS research criteria for prodromal Parkinson's disease: Longitudinal assessment in a REM sleep behavior disorder (RBD) cohort. (Abstract)

Validation of the MDS research criteria for prodromal Parkinson's disease: Longitudinal assessment in a REM sleep behavior disorder (RBD) cohort. Recently, the International Parkinson and Movement Disorder Society introduced the prodromal criteria for PD. Objectives Our study aimed to examine diagnostic accuracy of the criteria as well as the independence of prodromal markers to predict conversion to PD or dementia with Lewy bodies.This prospective cohort study was performed on 121 individuals (...) with rapid eye movement sleep behavior disorder who were followed annually for 1 to 12 years. Using data from a comprehensive panel of prodromal markers, likelihood ratio and post-test probability of the criteria were calculated at baseline and during each follow-up visit.Forty-eight (39.7%) individuals with rapid eye movement sleep behavior disorder converted to PD/dementia with Lewy bodies. The prodromal criteria had 81.3% sensitivity and 67.9% specificity for conversion to PD/dementia with Lewy bodies

2017 Movement Disorders

39. REM sleep behaviour disorder: not just a bad dream. (Abstract)

REM sleep behaviour disorder: not just a bad dream. Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia characterised by the loss of the normal atonia during the REM stage of sleep, resulting in overt motor behaviours that usually represent the enactment of dreams. Patients will seek medical attention due to sleep-related injuries or unpleasant dream content. Idiopathic RBD which occurs independently of any other disease occurs in up to 2% of the older population. Meanwhile (...) , secondary RBD is very common in association with certain neurodegenerative conditions. RBD can also occur in the context of antidepressant use, obstructive sleep apnoea and narcolepsy. RBD can be diagnosed with a simple screening question followed by confirmation with polysomnography to exclude potential mimics. Treatment for RBD is effective and involves treatment of underlying causes, modification of the sleep environment, and pharmacotherapy with either clonazepam or melatonin. An important finding

2017 Medical Journal of Australia

40. Prevalence of obstructive sleep apnoea in REM behaviour disorder: response to continuous positive airway pressure therapy Full Text available with Trip Pro

Prevalence of obstructive sleep apnoea in REM behaviour disorder: response to continuous positive airway pressure therapy Rapid eye movement behaviour disorder (RBD) is a parasomnia in which there is loss of muscle atonia during rapid eye movement (REM) sleep, resulting in dream enactment. The aims of this study were to determine the prevalence of obstructive sleep apnoea (OSA) in RBD patients and determine whether continuous positive airway pressure (CPAP) therapy improved RBD symptoms (...) in patients with concomitant RBD and OSA.A questionnaire was mailed to 120 patients identified from a tertiary sleep centre with RBD meeting full International Classification for Sleep Disorders-3 (ICSD-3) criteria. Patients were diagnosed as having OSA if they had an apnoea-hypopnea index (AHI) ≥ 5. The questionnaire focused on CPAP-use, compliance and complications. Standard statistical analysis was undertaken using SPSS (v.21, IBM).One hundred and seven of the potential participants (89.2%) had an OSA

2017 Sleep & breathing = Schlaf & Atmung

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