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REM Sleep Behavior Disorder


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281. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder

associated with comorbid anxiety, mood, and personality disorders in both civilians and veterans. 3,4 PTSD is also associated with cardiovascular disease, arthritis, asthma, chronic pain, diabetes, bone and joint conditions, and gastrointestinal disorders, 3 leading to high utilization of health services. The prevalence of PTSD and its impact on health and healthcare utilization has prompted extensive research on effective ways to treat it. In 2017, the Department of Veterans Affairs (VA (...) Treatments for Posttraumatic Stress Disorder: Groundwork for a Publicly Available Repository of Randomized Controlled Trial Data Structured Abstract Background. Posttraumatic stress disorder (PTSD) reduces quality of life and functioning. People with PTSD have symptoms such as intrusive thoughts, nightmares, flashbacks, avoidance of trauma-related stimuli, negative beliefs about themselves and/or others, and hypervigilance. The symptoms may be due to direct or indirect exposure to trauma

2019 Effective Health Care Program (AHRQ)

282. Validity of the Mattis Dementia Rating Scale to Detect Mild Cognitive Impairment in Parkinson's Disease and REM Sleep Behavior Disorder. (Abstract)

Validity of the Mattis Dementia Rating Scale to Detect Mild Cognitive Impairment in Parkinson's Disease and REM Sleep Behavior Disorder. Mild cognitive impairment (MCI) is frequent in Parkinson's disease (PD) and idiopathic REM sleep behavior disorder (iRBD). However, only a few studies have evaluated the validity of brief cognitive measures to detect MCI in PD or iRBD using standard diagnostic criteria for MCI. Our aim was to evaluate the validity of the Mini-Mental State Examination (MMSE

2011 Dementia and Geriatric Cognitive Disorders

283. Associated factors for REM sleep behavior disorder in Parkinson disease. (Abstract)

Associated factors for REM sleep behavior disorder in Parkinson disease. To investigate the frequency, phenomenology, and associated risk factors of REM sleep behavior disorder (RBD) in Parkinson disease (PD).An unselected cohort of sleep-disturbed patients with PD (n=457) was investigated with video-supported polysomnography. We determined the frequency of RBD and analyzed the influence of age, clinical disease features, disease duration, cognitive and physical impairment, medication (...) of levodopa (p=0.002). The presence of RBD was related to slightly increased sleep efficiency (p=0.007), a higher amount of REM sleep (p=0.000), and more periodic leg movements during sleep (p=0.019).RBD is a frequent and clinically relevant nocturnal disturbance for all stages of PD. It increases with age and disease duration and may contribute to the nocturnal problems of patients with PD and their bed partners.

2011 Neurology

284. Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder. (Abstract)

Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder. Recent studies have suggested a close connection between autonomic dysfunction and rapid eye movement sleep behavior disorder, which differs in nature from other early-stage markers of Parkinson's disease. In this study we examined the relationship between rapid eye movement sleep behavior disorder and autonomic dysfunction in Parkinson's disease as measured by cardiac beat-to-beat variability.In 53 (...) showed clear abnormalities compared with controls. However, these abnormalities were confined only to those patients with associated rapid eye movement sleep behavior; those without were not different than controls.As with other clinical autonomic variables, cardiac autonomic denervation is predominantly associated not with Parkinson's disease itself, but with the presence of rapid eye movement sleep behavior disorder.Copyright © 2011 Movement Disorder Society.

2011 Movement Disorders

285. Sleep disturbances in drug naïve Parkinson's disease (PD) patients and effect of levodopa on sleep Full Text available with Trip Pro

Stage III and REM sleep and increased sleep latency and wake after sleep onset time. Following levodopa, improved sleep efficiency with reduced sleep latency and wake after sleep onset time was noted, coupled with improved PDSS scores. However, NREM Stage III and REM sleep duration did not increase.PD patients take longer to fall asleep and have difficulty in sleep maintenance. Sleep maintenance is affected by nocturia, REM behavioral disorder, nocturnal cramps, akinesia, and tremors, as observed (...) Sleep disturbances in drug naïve Parkinson's disease (PD) patients and effect of levodopa on sleep Parkinson's disease (PD) is associated with sleep disturbances, attributed to the neurodegenerative process and therapeutic drugs. Studies have found levodopa to increase wakefulness in some patients while increasing sleepiness in others.To confirm sleep disturbances in drug naïve PD patients and understand the impact of levodopa on their sleep.Twenty-three drug naïve PD patients and 31 age

2014 Annals of Indian Academy of Neurology

286. Sleep-Disordered Breathing and PAP in Perinatal Depression

table for MeSH terms Depression Depressive Disorder Depressive Disorder, Major Respiratory Aspiration Sleep Apnea Syndromes Behavioral Symptoms Mood Disorders Mental Disorders Respiration Disorders Respiratory Tract Diseases Pathologic Processes Apnea Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Nervous System Diseases (...) with depression and sleep-disordered breathing. Participants will be randomly assigned to receive either PAP therapy (PAP group) or treatment as usual within obstetrics (TAU group). Mood and sleep assessments will be completed at baseline, after 1 week of enrollment, and monthly thereafter through 12 weeks postpartum. Cortisol will be measured using saliva collection at baseline and again 8 weeks later. Condition or disease Intervention/treatment Phase Sleep-disordered Breathing Major Depressive Disorder

2015 Clinical Trials

287. Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers Full Text available with Trip Pro

-PD, excessive daytime sleepiness (EDS) was a complaint in 33% patients and short sleep latencies on the MSLT, which are indicative of objective EDS, were found in 71%. Sleep attacks occurred in three LRRK2-PD patients and a narcoleptic phenotype was not observed. REM sleep behavior disorder (RBD) was diagnosed in three LRRK2-PD. EDS and RBD were always reported to start after the onset of parkinsonism in LRRK2-PD. In NMC, EDS was rarely reported and RBD was absent. When compared to IPD, sleep (...) Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers In idiopathic Parkinson disease (IPD) sleep disorders are common and may antedate the onset of parkinsonism. Based on the clinical similarities between IPD and Parkinson disease associated with LRRK2 gene mutations (LRRK2-PD), we aimed to characterize sleep in parkinsonian and nonmanifesting LRRK2 mutation carriers (NMC).A comprehensive interview conducted by sleep specialists, validated sleep scales and questionnaires

2015 PloS one

288. Effects of Sleep on Memory for Conditioned Fear and Fear Extinction. Full Text available with Trip Pro

Effects of Sleep on Memory for Conditioned Fear and Fear Extinction. Learning and memory for extinction of conditioned fear is a basic mammalian mechanism for regulating negative emotion. Sleep promotes both the consolidation of memory and the regulation of emotion. Sleep can influence consolidation and modification of memories associated with both fear and its extinction. After brief overviews of the behavior and neural circuitry associated with fear conditioning, extinction learning (...) deprivation experiments. REM sleep is accompanied by selective activation of the same limbic structures implicated in the learning and memory of fear and extinction. Preliminary evidence also suggests extinction learning can take place during slow wave sleep. Study of low-level processes such as conditioning, extinction, and habituation may allow sleep effects on emotional memory to be identified and inform study of sleep's effects on more complex, emotionally salient declarative memories. Anxiety

2015 Psychological Bulletin

289. Modeling sleep alterations in Parkinson's disease: How close are we to valid translational animal models? (Abstract)

. Alterations of the sleep/wakefulness behavior experienced as insomnia, excessive daytime sleepiness, sleep/wake cycle fragmentation and REM sleep behavior disorder are among the non-motor symptoms that predate motor alterations and inevitably worsen over disease progression. The absence of adequate humanized animal models with the perfect phenocopy of these sleep alterations contribute undoubtedly to the lack of efficient therapies for these non-motor complications. In the context of developing efficient (...) translational therapies, we provide an overview of the strengths and limitations of the various currently available models to replicate sleep alterations of Parkinson's disease. Our investigation reveals that although these models replicate dopaminergic deficiency and related parkinsonism, they rarely display a combination of sleep fragmentation and excessive daytime sleepiness and never REM sleep behavior disorder. In this light, we critically discuss the construct, face and predictive validities of both

2015 Sleep medicine reviews

290. Study to Evaluate the Effect of 2 Dosage Strengths of E2006 on a Multiple Sleep Latency Test in Subjects With Insomnia Disorder

oophorectomy, all with surgery at least 1 month before dosing). A current diagnosis of sleep-related breathing disorder, periodic limb movement disorder, restless legs syndrome, circadian rhythm sleep disorder, or narcolepsy, or an exclusionary score on screening instruments to rule out individuals with symptoms of certain sleep disorders other than insomnia. Reports experiencing within the past year confusional arousals, symptoms of REM Behavior Disorder, or sleep-related violent behavior on Munich (...) : Completed First Posted : January 29, 2015 Last Update Posted : November 3, 2015 Sponsor: Eisai Inc. Information provided by (Responsible Party): Eisai Inc. Study Details Study Description Go to Brief Summary: This is a single-dose, randomized, placebo-controlled, 3-way crossover study of 2 dosage strengths of E2006 (5 mg and 10 mg) in subjects with insomnia disorder. Condition or disease Intervention/treatment Phase Insomnia Disorder Drug: E2006 5 mg Drug: E2006 10 mg Drug: E2006-matched placebo Drug

2015 Clinical Trials

291. Sleep and behavior during vesicular stomatitis virus induced encephalitis in BALB/cJ and C57BL/6J mice. Full Text available with Trip Pro

Sleep and behavior during vesicular stomatitis virus induced encephalitis in BALB/cJ and C57BL/6J mice. Intranasal application of vesicular stomatitis virus (VSV) produces a well-characterized model of viral encephalitis in mice. Within one day post-infection (PI), VSV travels to the olfactory bulb and, over the course of 7 days, it infects regions and tracts extending into the brainstem followed by clearance and recovery in most mice by PI day 14 (PI 14). Infectious diseases are commonly (...) consecutive days and analyzed on PI 0, 1, 3, 5, 7, 10, and 14. Compared to baseline, amounts of non-rapid eye movement sleep (NREM) were increased in B6 mice during the dark period of PI 1-5, whereas rapid eye movement sleep (REM) was significantly reduced during the light periods of PI 0-14. In contrast, BALB/c mice showed significantly fewer changes in NREM and REM. These data demonstrate sleep architecture is differentially altered in these mouse strains and suggests that, in B6 mice, VSV can alter

2014 Brain, behavior, and immunity

292. Pharmacological Targeting of the Mammalian Clock Regulates Sleep Architecture and Emotional Behavior Full Text available with Trip Pro

Pharmacological Targeting of the Mammalian Clock Regulates Sleep Architecture and Emotional Behavior Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the potential to directly modulate the endogenous circadian rhythm and treat diseases associated with clock dysfunction. Here we demonstrate that synthetic ligands targeting a key component of the mammalian clock, the nuclear receptors REV-ERBα and β, regulate sleep architecture and emotional behaviour (...) in mice. REV-ERB agonists induce wakefulness and reduce REM and slow-wave sleep. Interestingly, REV-ERB agonists also reduce anxiety-like behaviour. These data are consistent with increased anxiety-like behaviour of REV-ERBβ-null mice, in which REV-ERB agonists have no effect. These results indicate that pharmacological targeting of REV-ERB may lead to the development of novel therapeutics to treat sleep disorders and anxiety.

2014 Nature communications

293. Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression

or early neurodegenerative dis- orders. Here, our data shows that greater nocturnal wakefulness as measured by actigraphic monitoring Figure 3 The normal synchronous relationships between sleep and daytime activity and cortisol, melatonin and body temperature. Hickie et al. BMC Medicine 2013, 11:79 Page 11 of 27 to neuropsychological dysfunction in late-life de- pression [43], mild cognitive impairment [257], and REM sleep behavior disorder (...) depression, but expressed to a lesser degree [177-184] ? Biological rhythms Higher levels of ‘eveningness’ preference [70] Lower circadian amplitude [185] Delayed sleep phase and melatonin onset, especially in those with bipolar disorder [123,212] Elevated evening/nighttime cortisol levels [186,187] Late-life depression ? Macro and microarchitecture of sleep Lower increase in REM sleep duration [136] Otherwise similar features to that seen in adult depression, but more pronounced [136] ? Biological

2013 Clinical Practice Guidelines Portal

294. Practice Guideline Update Systematic Review Summary: Disorders of Consciousness

on a speakers bureau for Allergan Inc.; and receives research support from the NIH Office of Rare Diseases Research via the Dystonia Coalition, unrelated to the content of this guideline. His spouse has received an NIH grant unrelated to the content of this guideline. 5 F. Hammond is a member of the ACRM Disorders of Consciousness Task Force; served on the US Department of Defence INTrust Scientific Advisory Council and Avanir Prism II Study Steering Committee; has received royalties from Demos Publishing (...) diagnostic assessment procedures that incorporate the Aspen Neurobehavioral Workgroup criteria accurately detect behavioral signs of consciousness or differentiate specific DoCs (VS/UWS, MCS, and posttraumatic confusional state [PTCS]) compared with consensus-based diagnostic opinion or standardized behavioral assessment. Readers are referred to a previously published systematic review completed by the ACRM Disorders of Consciousness Task Force that provides evidence-based recommendations for clinical

2018 American Academy of Neurology

295. Position Paper for the Treatment of Nightmare Disorder in Adults

functioning (eg, nighttime disruption). Behavioral problems (eg, bedtime avoidance, fear of the dark). Daytime sleepiness. Fatigue or low energy. Impaired occupational or educational function. Impaired interpersonal/social function. Nightmare disorder is common, affecting 4% of the adult population in the United States. Nightmare disorder negatively impacts quality of life, resulting in sleep avoidance and deprivation. – It can also cause or exacerbate underlying psychiatric distress and illness (...) significantly impair quality of life. This paper provides the American Academy of Sleep Medicine (AASM) position regarding various treatments of nightmare disorder in adults. Methods: A literature search was performed based upon the keywords and MeSH terms from the Best Practice Guide for the Treatment of Nightmare Disorder in Adults that was published in 2010 by the AASM. The search used the date range March 2009 to August of 2017, and sought to find available evidence pertaining to the use of behavioral

2018 American Academy of Sleep Medicine

296. Comprehensive Systematic Review Summary: Disease-modifying Therapies for Adults with Multiple Sclerosis

Academy of Neurology AEs: adverse effects ALT: alanine aminotransferase ARRs: annualized relapse rates AST: aspartate aminotransferase CIS: clinically isolated syndrome CMSC: Consortium of Multiple Sclerosis Centers” COI: conflict of interest CV: curriculum vitae DMTs: disease-modifying therapies EDSS: Expanded Disability Status Scale FDA: US Food and Drug Administration GDDI: Guideline Development, Dissemination, and Implementation Subcommittee IOM: Institute of Medicine mIUs: milli-international (...) , and stopping disease-modifying therapies (DMTs) for multiple sclerosis (MS) in people with clinically isolated syndrome (CIS), relapsing ?remitting MS (RRMS), and progressive forms of MS; and to develop recommendations for starting, switching, and stopping DMTs. Methods: The guideline panel followed the American Academy of Neurology (AAN) 2011 guideline development process, as amended. Relevant, peer-reviewed research articles, systematic reviews, and abstracts were identified using a literature search

2018 American Academy of Neurology

297. Behavioural and Cognitive-Behavioural Treatments of Parasomnias Full Text available with Trip Pro

Behavioural and Cognitive-Behavioural Treatments of Parasomnias Parasomnias are unpleasant or undesirable behaviours or experiences that occur predominantly during or within close proximity to sleep. Pharmacological treatments of parasomnias are available, but their efficacy is established only for few disorders. Furthermore, most of these disorders tend spontaneously to remit with development. Nonpharmacological treatments therefore represent valid therapeutic choices. This paper reviews (...) behavioural and cognitive-behavioural managements employed for parasomnias. Referring to the ICSD-3 nosology we consider, respectively, NREM parasomnias, REM parasomnias, and other parasomnias. Although the efficacy of some of these treatments is proved, in other cases their clinical evidence cannot be provided because of the small size of the samples. Due to the rarity of some parasomnias, further multicentric researches are needed in order to offer a more complete account of behavioural and cognitive

2015 Behavioural neurology

298. Diffuse Lewy body disease manifesting as corticobasal syndrome: A rare form of Lewy body disease. Full Text available with Trip Pro

-Rolandic cortices in CBS, we used digital pathology to count Lewy bodies and to quantify intracytoplasmic and neuritic α-synuclein and phospho-tau burden in the motor cortex.DLBD patients with antemortem features of CBS were significantly younger at disease onset and less likely to have REM sleep behavior disorder than DLBD cases who met clinical criteria for DLB during life. Patients with DLBD manifesting as CBS had more Lewy bodies in the motor cortex than DLBD manifesting as clinically probable DLB (...) Diffuse Lewy body disease manifesting as corticobasal syndrome: A rare form of Lewy body disease. To describe clinical and pathologic characteristics of diffuse Lewy body disease (DLBD) manifesting as corticobasal syndrome (CBS).In 523 autopsy-confirmed cases of DLBD, we identified 11 patients diagnosed with CBS. For comparison, we studied 22 DLBD brains with antemortem presentation of dementia with Lewy bodies (DLB). Given previous studies suggesting the importance of pathology in peri

2018 Neurology

299. Genetic Activation, Inactivation, and Deletion Reveal a Limited And Nuanced Role for Somatostatin-Containing Basal Forebrain Neurons in Behavioral State Control Full Text available with Trip Pro

neurons and somatostatin-containing BFVGAT neurons (BFSOM neurons), and it was recently reported that optogenetic activation of BFSOM neurons increases the probability of a wakefulness to non-rapid-eye movement (NREM) sleep transition when stimulated during the rest period of the animal. This finding was unexpected given that most BFSOM neurons are not NREM sleep active and that central administration of the synthetic somatostatin analog, octreotide, suppresses NREM sleep or increases REM sleep. Here (...) of GABAergic somatostatin-containing BF neurons to arousal control. Understanding the respective contribution of BF cell populations to arousal control may provide critical insight into the pathogenesis of a host of neuropsychiatric and neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, schizophrenia, and the cognitive impairments of normal aging.Copyright © 2018 the authors 0270-6474/18/385168-14$15.00/0.

2018 The Journal of Neuroscience

300. A motor signature of REM sleep behavior disorder. (Abstract)

A motor signature of REM sleep behavior disorder. The purpose of this study was to determine if there was a common pattern in movements during REM sleep behavior disorder (RBD).We blindly compared video-monitored movements during RBD (n = 136 clips) and wakefulness/arousal (n = 53 clips) in patients with Parkinson's disease (n = 29) and without parkinsonism (idiopathic RBD, n = 31; narcolepsy, n = 5).The scorers accurately guessed the sleep/wake stage of 94% of video clips. Compared with wake (...) movements, RBD movements were faster and more often repeated, jerky, and pseudohallucinatory, not self-centered, never associated with tremor, and rarely involved the environment in an appropriate manner. A specific posture of the hand (limp wrist with flexed digits) during grasping movements was evidenced during RBD in 48% of patients, reminiscent of hand-babbling in babies.These characteristics of movements were found in the 3 conditions (Parkinson's disease, idiopathic RBD, and primary narcolepsy

2011 Movement Disorders

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