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REM Sleep Behavior Disorder

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261. Assessment of Sleep by WHOOP in Ambulatory Subjects

Volunteers: Yes Criteria Inclusion Criteria: Ability to provide informed consent Willingness to undergo a polysomnography electrode hook-up and wear a WHOOP strap 2.0. Healthy volunteers Exclusion Criteria: Presence of untreated sleep disorder that requires diagnostic testing and treatment (insomnia, obstructive sleep apnea, narcolepsy, restless leg syndrome, REM sleep behavior disorder, or circadian rhythm sleep disorders). Apnea-Hypopnea index greater than or equal to 15 per hour as per AASM guidelines (...) of the WHOOP Strap 2.0 device on sleep perception and perform a methodological study to validate the accuracy of the the WHOOP Strap 2.0 device when measuring HR accuracy and HRV accuracy, and sleep quality and quantity with respect to PSG in healthy volunteers with no self-reported sleep disorders or debilitating medical conditions. Condition or disease Intervention/treatment Phase Sleep Quality Device: WHOOP Strap 2.0 Not Applicable Detailed Description: Polysomnography (PSG) is still considered

2018 Clinical Trials

262. Sleep, Stress and Learning: an Experimental Pilot Study

, Helsinki University Study Details Study Description Go to Brief Summary: To investigate the efficiency and effect of a programmed slow-breathing exercise in the evening to the heart rate variability, sleep quality and memory performance over night. Condition or disease Intervention/treatment Phase Stress Sleep Behavioral: Music listening Behavioral: Slow breathing Not Applicable Detailed Description: Background Stress and increased alertness in the evening are major reasons for sleep onset problems (...) the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 20 Years to 45 Years (Adult) Sexes Eligible for Study: All Gender Based Eligibility: Yes Gender Eligibility Description: 10 males, 10 females Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: age 20-45 Exclusion Criteria: chronic disease requiring daily medication, acute sickness (e.g. a flu), jet lag from a recent travel, current diagnosed sleep disorder (such as snoring

2018 Clinical Trials

263. Sleep Related Problems as a Nonmotor Symptom of Dentatorubropallidoluysian Atrophy Full Text available with Trip Pro

decline. The patients commonly showed dream enacting sleep disorder, insomnia. The results from overnight polysomnography showed rapid eye movement (REM) without atonia in patients with DRPLA. The man died 2 years after diagnosis and was subjected for brain autopsy. We report REM sleep behavior disorders in patients with DRPLA confirmed with polysomnography with pathological description of the patient. (...) Sleep Related Problems as a Nonmotor Symptom of Dentatorubropallidoluysian Atrophy Dentatorubropallidoluysian atrophy (DRPLA) is a neurodegenerative disease caused by an expansion of a cytosine-adenine-guanine (CAG) repeat encoding a polyglutamine tract in the atrophin-1 protein. Unlike other CAG repeat diseases, sleep related problems have not been reported in patients with DRPLA. There was a 65-year-old man and his family with DRPLA. They suffered from seizure, gait disturbance, and cognitive

2018 Journal of Korean medical science

264. Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression Full Text available with Trip Pro

of the recently described mutant strain of Han Wistar rats, which do not express mGluR2 receptors, to investigate behavioural, sleep and EEG responses to mGluR2/3 ligands. The mGluR2/3 agonist, LY354740 (10 mg/kg), reversed amphetamine- and phencyclidine-induced locomotion and rearing behaviours in control Wistar but not in mGluR2 lacking Han Wistar rats. In control Wistar but not in Han Wistar rats the mGluR2/3 agonist LY379268 (3 & 10 mg/kg) induced REM sleep suppression with dose-dependent effects on wake (...) Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression Group II metabotropic glutamate receptors (mGluR2 and mGluR3) are implicated in a number of psychiatric disorders. They also control sleep-wake architecture and may offer novel therapeutic targets. However, the roles of the mGluR2 versus mGluR3 subtypes are not well understood. Here, we have taken advantage

2018 Neuropharmacology

265. Modulation of Motoneuronal Activity With Sleep-Wake States and Motoneuronal Gene Expression Vary With Circadian Rest-Activity Cycle Full Text available with Trip Pro

cycle, thereby separating amplitude measurements from the known dependance of the timing of wake and sleep on the phase of circadian rest-activity cycle. In seven rats chronically instrumented for electroencephalogram and EMG monitoring, nuchal and lingual muscle EMGs were measured as a commonly used postural output in behavioral sleep studies and as a cranial motor output with potential clinical relevance in obstructive sleep apnea (OSA) syndrome, respectively. We found that, for both motor outputs (...) , EMG measured during wake episodes was significantly higher during the active phase, than during the rest phase, of circadian cycle. The corresponding patterns observed during slow-wave sleep (SWS) and rapid eye movement sleep (REMS) were different. During SWS, lingual EMG was very low and did not differ between the rest and active phase, whereas nuchal EMG had pattern similar to that during wakefulness. During REMS, lingual EMG was, paradoxically, higher during the rest phase due to increased

2018 Frontiers in integrative neuroscience

266. The Acute Effect of Aerobic Exercise on Sleep in Patients With Depression

: October 30, 2018 See Sponsor: Oberwaid AG Collaborators: Institute for Exercise and Health Sciences, University of Basle, Switzerland University of Zurich University of Basel Information provided by (Responsible Party): Oberwaid AG Study Details Study Description Go to Brief Summary: The aim of this trial is to investigate the effects of a single bout of aerobic exercise on sleep in patients with depression. Condition or disease Intervention/treatment Phase Depression Sleep Sleep Disorder Sleep (...) Disturbance Sleep Fragmentation Sleep Initiation and Maintenance Disorders Insomnia Insomnia, Psychophysiological Insomnia Due to Other Mental Disorder Insomnia Related to Another Mental Condition Behavioral: Aerobic exercise, bicycle ergometer Not Applicable Detailed Description: PRIMARY OBJECTIVE: The primary objective of this study is to evaluate whether a single bout of aerobic exercise improves sleep efficiency more than a control condition in patients with depression. SECONDARY OBJECTIVES: Secondary

2018 Clinical Trials

267. Comparison of Dreem to Clinical PSG for Sleep Monitoring in Apnea Patients

by (Responsible Party): Dreem Study Details Study Description Go to Brief Summary: This study aims to evaluate the accuracy of apnea detection and automated sleep analysis by the Dreem dry-EEG headband and deep learning algorithm in comparison to the consensus of 5 sleep technologists' manual scoring of a gold-standard clinical polysomnogram (PSG) record in adults during a physician-referred overnight sleep study due to suspicion of sleep-disordered breathing. Condition or disease Intervention/treatment Phase (...) and split-night studies) Exclusion Criteria: Concomitant diagnosis of a sleep disorder other than sleep apnea syndrome or insomnia Morbid obesity (BMI > 39) Use of benzodiazepines, nonbenzodiazepine (Z-drugs), or Gammahydroxybutyrate (GHB) the day/night of the study Concomitant diagnosis of cardiopulmonary or neurological comorbidities (such as heart failure, COPD, neurodegenerative conditions) Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study

2018 Clinical Trials

268. Investigational Test of a New Sleep Supplement

: Control Dietary Supplement: Proprietary Blend And Melatonin Dietary Supplement: Melatonin Not Applicable Detailed Description: Sleep disturbance is common in adults and when it persists may result in chronic disease, excess health care utilization, mental disorders, health-risk behaviors, limitations of daily functioning, lost productivity, injury, and mortality (IOM 2006). An estimated 50-70 million adults in the United States have chronic sleep and wakefulness disorders (IOM 2006; Ram 2010) and many (...) Information provided by (Responsible Party): Michael A. Grandner, University of Arizona Study Details Study Description Go to Brief Summary: This study seeks to observe the effects of a proprietary spearmint extract and green tea blend on sleep quality and duration. The study observes the effect of the supplement regarding sleep quality, and mental health. Condition or disease Intervention/treatment Phase Sleep Mood Cognitive Performance Dietary Supplement: Proprietary Spearmint Extract Blend Other

2018 Clinical Trials

269. Study to Assess the Efficacy and Safety of ACT-541468 in Adult and Elderly Subjects Suffering From Difficulties to Sleep

. ClinicalTrials.gov Identifier: NCT03575104 Recruitment Status : Recruiting First Posted : July 2, 2018 Last Update Posted : March 13, 2019 See Sponsor: Idorsia Pharmaceuticals Ltd. Information provided by (Responsible Party): Idorsia Pharmaceuticals Ltd. Study Details Study Description Go to Brief Summary: The main purpose of this Phase 3 study is to evaluate the efficacy of 10 mg and 25 mg ACT-541468 on objective sleep parameters in subjects with insomnia disorder. Condition or disease Intervention/treatment (...) and use the contraception scheme up to at least 30 days after last study treatment intake. Exclusion Criteria: Body mass index below 18.5 or above 40.0 kg/m2; Any lifetime history of of related breathing disorder, periodic limb movement disorder, restless legs syndrome, circadian rhythm disorder, rapid eye movement (REM) behavior disorder, narcolepsy, or apnea/hypopnea; Cognitive behavioral therapy (CBT) only allowed if, the treatment started at least 1 month prior to Visit 3 and the subject agrees

2018 Clinical Trials

270. Sleep Structure in Refugees Diagnosed With PTSD

] Assessing sleep quality and sleep disorders Disturbing dreams and Nightmare Severity Index (DDNSI) [ Time Frame: 10 minutes ] Assessing nightmares REM Sleep Behavior Disorder Screening Questionnaire (RBDSC) [ Time Frame: 10 minutes ] Assessing REM Sleep Behavior Disorders Life Events Checklist for DSM-5 (LEC-5) - extended version [ Time Frame: 10 minutes ] Screening of potential traumatic events Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate (...) Collaborator: Danish Center for Sleep Medicine Information provided by (Responsible Party): Mia Beicher Ansbjerg, Mental Health Services in the Capital Region, Denmark Study Details Study Description Go to Brief Summary: The aim of this study is to examine sleep structure in refugees with PTSD. Polysomnography (PSG) will be carried out to study the occurrence of sleep disorders in patients and healthy controls. Condition or disease Intervention/treatment PTSD Sleep Disorder Other: Polysomnography Detailed

2018 Clinical Trials

271. A Study to Investigate the Effects of ACT-541468 on Nighttime Respiratory Function in Patients With Mild to Moderate Obstructive Sleep Apnea

index ≥ 10/h, restless legs syndrome, circadian rhythm disorder, REM behavior disorder, parasomnia including nightmare disorder, sleep terror disorder, and/or sleepwalking disorder. Need for continuous positive airway pressure device or a dental appliance device within the preceding 7 days prior to Screening Visit 2 and during the course of the study, i.e., from Screening Visit 2 to EOS. Evidence of any other clinically significant active pulmonary disease such as chronic obstructive pulmonary (...) Sleep Apnea Syndromes Sleep Apnea, Obstructive Respiration Disorders Respiratory Tract Diseases Signs and Symptoms, Respiratory Signs and Symptoms Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Nervous System Diseases

2018 Clinical Trials

272. Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease Full Text available with Trip Pro

adolescents is ≈10% (8.7% for MDD, 2.6% for BD). By comparison, the prevalence of the 4 existing Expert Panel tier II moderate-risk conditions ranges from ≈0.5% (chronic inflammatory disease) to <0.05% (HIV, Kawasaki disease, nephrotic syndrome). In other words, MDD and BD together are at least 10 times more prevalent than the 4 previously identified moderate-risk conditions combined. Because mood disorders are highly prevalent among adolescents and are generally amenable to treatment, there could (...) Medications and Cardiovascular Risk Factors in Youth.” Behavioral and Environmental Factors Contributing to CVD Risk A number of behavioral and psychosocial characteristics that are disproportionately prevalent among adolescents and young adults with mood disorders are associated with increased CVD risk. Such characteristics include early maltreatment, sleep disturbance, sedentary lifestyle, suboptimal nutrition, and tobacco smoking and substance abuse. Early Maltreatment This section focuses

2015 American Heart Association

273. Guidance on the clinical management of anxiety disorders, specifically focusing on diagnosis and treatment strategies

, professional bodies, and specialist groups with interest and expertise in anxiety disorders. Results: The guidelines recommend a pragmatic approach beginning with psychoeducation and advice on lifestyle fac- tors, followed by initial treatment selected in collaboration with the patient from evidence-based options, taking into account symptom severity, patient preference, accessibility and cost. Recommended initial treatment options for all three anxiety disorders are cognitive–behavioural therapy (face (...) . Overview of the management of anxiety disorders. CBT: cognitive–behavioural therapy. CBT can be delivered face-to-face by an experienced clinician or as guided digital CBT. dCBT: guided digital CBT (CBT accessed by computer, tablet or smartphone application). §Watchful waiting includes monitoring response to psychoeducation and lifestyle measures. *For the purpose of initial treatment choice, mild, moderate and severe are defined pragmatically, according to effect on function, as inability to perform

2018 Royal Australian and New Zealand College of Psychiatrists

274. Memory consolidation in sleep disorders. (Abstract)

in the consolidation of declarative and procedural information. On the other hand, patients with parasomnias, such as sleep-walking, night terrors and rapid eye movement (REM) behavior disorder, do not present any memory impairment. These studies suggest that only sleep disorders characterized by increased post-learning arousal and disrupted sleep architecture seem to be associated with offline memory consolidation issues. Such impairments, arising already in childhood, may potentially affect the development (...) Memory consolidation in sleep disorders. In recent years sleep-related memory consolidation has become a central topic in the sleep research field. Several studies have shown that in healthy individuals sleep promotes memory consolidation. Notwithstanding this, the consequences of sleep disorders on offline memory consolidation remain poorly investigated. Research studies indicate that patients with insomnia, obstructive sleep apnea, and narcolepsy often exhibit sleep-related impairment

2016 Sleep medicine reviews

275. Individual Differences in Animal Stress Models: Considering Resilience, Vulnerability, and the Amygdala in Mediating the Effects of Stress and Conditioned Fear on Sleep Full Text available with Trip Pro

Individual Differences in Animal Stress Models: Considering Resilience, Vulnerability, and the Amygdala in Mediating the Effects of Stress and Conditioned Fear on Sleep To examine the REM sleep response to stress and fearful memories as a potential marker of stress resilience and vulnerability and to assess the role of the basolateral amygdala (BLA) in mediating the effects of fear memory on sleep.Outbred Wistar rats were surgically implanted with electrodes for recording EEG and EMG (...) -Res; n = 13), MUS-vulnerable (MUS-Vul; n = 8), and MUS-resilient (MUS-Res; n = 11) based on whether or not REM was decreased, compared to baseline, during the first 4 h following ST. We then compared sleep, freezing, and the stress response (stress-induced hyperthermia, SIH) across groups to determine the effects of ST and fearful context re-exposure alone (CTX).REM was significantly reduced on the ST day in both VEH-Vul and MUS-Vul rats; however, post-ST MUS blocked the reduction in REM

2016 Sleep

276. Sleep Disturbances in Posttraumatic Stress Disorder: Updated Review and Implications for Treatment Full Text available with Trip Pro

Sleep Disturbances in Posttraumatic Stress Disorder: Updated Review and Implications for Treatment Sleep disturbances are common in adults with PTSD and range from insomnia and nightmares to periodic leg movements and disruptive nocturnal behaviors. Together these findings suggest profound disturbances in rapid eye movement (REM) and non-REM (NREM) sleep, although there is a lack of consensus regarding a distinct profile of objective sleep disturbances associated with PTSD. Prospective (...) , longitudinal studies have established that sleep disturbances represent a risk factor for the development and course of PTSD, suggesting that sleep is an important neurobiological mechanism in the etiology and maintenance of this disorder. This research highlights the importance of early identification and treatment of sleep disturbances in at-risk and trauma exposed populations. A number of psychological and pharmacological treatments are effective at treating sleep disturbances in PTSD. Additional

2016 Psychiatric Annals

277. Sleep Pathology in Creutzfeldt-Jakob Disease Full Text available with Trip Pro

, and 10 (77%) had sleep-disordered breathing. Of the 8 patients who experienced rapid eye movement (REM) sleep during the polysomnography, 3 (38%) showed REM sleep without atonia, and 2 patients met criteria for REM sleep behavior disorder. Median total sleep time was 226 (interquartile range [IQR] = 195-282) min. Median sleep efficiency was 58.5% (IQR = 41-65.5 %). Median REM time was 0.35% (IQR = 0-7.125%). Five patients (38%) demonstrated periodic limb movements during polysomnography. One case (...) Sleep Pathology in Creutzfeldt-Jakob Disease Associations between sleep and neurodegenerative diseases have become increasingly evident. This study aims to characterize the prevalence and type of sleep pathology in Creutzfeldt-Jakob disease (CJD), a rapidly progressive, fatal neurodegenerative disease.In this observational cross-sectional cohort study, we performed a retrospective analysis of sleep signs and symptoms in a consecutive group of patients with definite CJD at a tertiary care

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

278. Suvorexant and Sleep's Benefits to Therapeutic Exposure for Posttraumatic Stress Disorder

) on sleep, PTSD symptoms, and intersession habituation. Condition or disease Intervention/treatment Phase Posttraumatic Stress Disorder Drug: suvorexant Other: placebo Phase 4 Detailed Description: Cognitive behavioral therapies (CBT) that include exposure to trauma memories are considered first line treatments for PTSD. However, approximately 1/3 of patients who complete CBT for PTSD do not achieve remission, and hyperarousal symptoms including sleep disturbances are less responsive to CBT than other (...) of insomnia. Suvorexant reduced WASO and latency to persistent sleep and increased SWS and REM sleep in humans with insomnia. In addition, administrations of orexin-A increased anxiety-like behaviors in rodents, and administrations of an orexin receptor-1 antagonist to mice facilitated extinction of conditioned fear, an animal model of recovery from PTSD and anxiety disorders. Objective: To examine effects of blocking the orexin system with suvorexant after WNE on sleep, PTSD symptoms, and intersession

2016 Clinical Trials

279. Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease

(The REM sleep Behavior Disorder screening Questionnaire) [ Time Frame: Baseline and immediately after administering the drug for 4 weeks ] Variations in PDQ-39(The 39-Item Parkinson's Disease Questionnaire) [ Time Frame: Baseline and immediately after administering the drug for 4 weeks ] Other Outcome Measures: Variations in CGI(Clinical Global Impression) [ Time Frame: Baseline and immediately after administering the drug for 4 weeks ] Variations in PGI(Patient Global Impression) [ Time Frame (...) Update Posted : May 18, 2016 Sponsor: Kuhnil Pharmaceutical Co., Ltd. Information provided by (Responsible Party): Kuhnil Pharmaceutical Co., Ltd. Study Details Study Description Go to Brief Summary: This clinical study is a double-blind, randomized, placebo-controlled trial to investigate the effects of melatonin on the sleep disturbance symptoms of Parkinson's disease patients, symptoms which have a significant impact on the quality of life of these patients. Condition or disease Intervention

2016 Clinical Trials

280. Practice Guidelines for the Perioperative Management of Patients with Obstructive Sleep Apnea

studies report other pertinent patient characteristics associated with OSA that may be available in medical records, such as hypertension, history of stroke, , history of myocardial infarction, diabetes mellitus, or abnormal cephalometric measurements. ( Category B1-H evidence ). Noncomparative observational studies and case reports indicate that certain congenital conditions ( e.g. , Down syndrome, acromegaly) and disease states ( e.g. , neuromuscular disease, cerebral palsy) may also be associated (...) , expert and practitioner opinion, open-forum commentary, and clinical feasibility data. This document updates the “Practice Guidelines for the Perioperative Management of Obstructive Sleep Apnea: a Report by the American Society of Anesthesiologists Task Force on Perioperative Management of Obstructive Sleep Apnea,” adopted by the ASA in 2005 and published in 2006. Methodology A. Definition of Obstructive Sleep Apnea Obstructive sleep apnea (OSA) is a syndrome characterized by periodic, partial

2014 American Society of Anesthesiologists

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