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REM Sleep Behavior Disorder

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221. Determinants of unintentional leak during CPAP treatment in obstructive sleep apnea syndrome. (Abstract)

with OSA syndrome treated with auto-CPAP were analyzed (23 women; 56 ± 13 years; BMI, 32.9 kg/m2 (range, 29.0-38.0 kg/m2). Polysomnographic recordings were obtained under auto-CPAP, and mandibular behavior was measured with a magnetic sensor. After sleep and respiratory scoring, polysomnographic signals were computed as mean values over nonoverlapping 10-s intervals. The presence/absence of unintentional leakage was dichotomized for each 10-s interval (yes/no). Univariate and multivariate conditional (...) Determinants of unintentional leak during CPAP treatment in obstructive sleep apnea syndrome. Unintentional leakage from the mouth or around the mask may lead to cessation of CPAP treatment; however, the causes of unintentional leaks are poorly understood. The objectives of this study were (1) to identify determining factors of unintentional leakage and (2) to determine the effect of the type of mask (nasal/oronasal) used on unintentional leakage.Seventy-four polysomnograms from patients

2017 Chest

222. Disturbed EEG sleep, paranoid cognition and somatic symptoms identify veterans with post-traumatic stress disorder Full Text available with Trip Pro

Disturbed EEG sleep, paranoid cognition and somatic symptoms identify veterans with post-traumatic stress disorder Chronic post-traumatic stress disorder (PTSD) behavioural symptoms and medically unexplainable somatic symptoms are reported to occur following the stressful experience of military combatants in war zones.To determine the contribution of disordered EEG sleep physiology in those military combatants who have unexplainable physical symptoms and PTSD behavioural difficulties following (...) Inventory and the Wahler Physical Symptom Inventory. Statistical group comparisons employed linear models, logistic regression and chi-square automatic interaction detection (CHAID)-like decision trees.Veterans with PTSD were more likely than those without PTSD to show disturbances in non-rapid eye movement (REM) and REM sleep including delayed sleep onset, less efficient EEG sleep, less stage 4 (deep) non-REM sleep, reduced REM and delayed onset to REM. There were no group differences in the prevalence

2016 BJPsych open

223. The Role of the Circadian System in Neurological Sleep-wake Disorders

throughout our study protocol to explore better classification of sleep and wake phases and patterns of the rest-activity rhythm. This study is designed as an observational case-controlled study targeting the disorders of narcolepsy type 1 and idiopathic hypersomnia, and including interventional procedures in the healthy control group (sleep deprivation, sleep restriction) in a counter-balanced design. Condition or disease Intervention/treatment Phase Narcolepsy 1 Idiopathic Hypersomnia Behavioral: Sleep (...) Sponsor: Esther Werth Information provided by (Responsible Party): Esther Werth, University of Zurich Study Details Study Description Go to Brief Summary: The aim of this study is to investigate the role of the circadian system in patients with neurologic sleep-wake disorders. Therefore, overnight sleep will be distributed over 30 hours into repetitive sleep-wake cycles (poly-nap protocol), so that sleep episodes occur at different circadian phases. Vigilance, attention, risk behavior as well as sleep

2017 Clinical Trials

224. Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease

Co., Ltd. Information provided by (Responsible Party): KIMJisun, Samsung Medical Center Study Details Study Description Go to Brief Summary: This clinical study is a double-blind, randomized, placebo-controlled trial to investigate the effects of melatonin on the sleep disturbance symptoms of Parkinson's disease patients, symptoms which have a significant impact on the quality of life of these patients. Condition or disease Intervention/treatment Phase Parkinson's Disease Drug: Melatonin(Circadin (...) to sleep for a period of 4 weeks. Drug: Placebo Oral Tablet Outcome Measures Go to Primary Outcome Measures : Variation in PSQI(Pittsburgh Sleep Quality Index) [ Time Frame: Baseline and immediately after administering the drug for 4 weeks ] Variation in PSQI before and immediately after the administration of the drug Secondary Outcome Measures : Variations in RBDQ(The REM sleep Behavior Disorder screening Questionnaire) [ Time Frame: Baseline and immediately after administering the drug for 4 weeks

2017 Clinical Trials

225. Trauma associated sleep disorder: A parasomnia induced by trauma. (Abstract)

Trauma associated sleep disorder: A parasomnia induced by trauma. Nightmares and disruptive nocturnal behaviors that develop after traumatic experiences have long been recognized as having different clinical characteristics that overlap with other established parasomnia diagnoses. The inciting experience is typically in the setting of extreme traumatic stress coupled with periods of sleep disruption and/or deprivation. The limited number of laboratory documented cases and symptomatic overlap (...) with rapid eye movement sleep behavior disorder (RBD) and posttraumatic stress disorder (PTSD) have contributed to difficulties in identifying what is a unique parasomnia. Trauma associated sleep disorder (TSD) incorporates the inciting traumatic experience and clinical features of trauma related nightmares and disruptive nocturnal behaviors as a novel parasomnia. The aims of this theoretical review are to 1) summarize the known cases and clinical findings supporting TSD, 2) differentiate TSD from

2017 Sleep medicine reviews

226. Do Sleep and Circadian Rhythm Disturbances Impact the Cognitive and Behavioural Development of Children With Autism?

; sleep and circadian rhythm disturbances, most notably abnormal melatonin secretion, impact the cognitive and behavioural development of children with ASD, depending on age (prospective longitudinal analyses). Condition or disease Intervention/treatment Phase Autism Spectrum Disorder Other: polysomnography Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 105 participants Intervention Model: Single Group Assignment (...) ] Secondary Outcome Measures : presence of an intrinsic sleep disorders (e.g. obstructive or central sleep apnea syndrome, restless legs syndrome and periodic limb movements during sleep…) [ Time Frame: Three annual assessments: baseline, 1 year follow-up, 2 year follow-up ] Total sleep time (TST) [ Time Frame: Three annual assessments: baseline, 1 year follow-up, 2 year follow-up ] Time and percentage of TST spent in different sleep stages (slow wave sleep, rapid eye movement (REM) sleep) [ Time Frame

2016 Clinical Trials

227. Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease Full Text available with Trip Pro

Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease Over 50% of persons with idiopathic REM sleep behavior disorder (RBD) will develop Parkinson disease (PD) or dementia. At present, there is no way to predict who will develop disease. Since polysomnography is performed in all patients with idiopathic RBD at diagnosis, there is an opportunity to analyze if baseline sleep variables predict eventual neurodegenerative disease.In a longitudinally studied (...) 41.0 +/- 6.0%, p = 0.002), and not in those who developed dementia (54.3 +/- 10.3, p = 0.28). There was no difference in phasic submental REM EMG activity between groups.In patients with REM sleep behavior disorder initially free of neurodegenerative disease, the severity of REM atonia loss on baseline polysomnogram predicts the development of Parkinson disease.

2010 EvidenceUpdates

228. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. (Abstract)

Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. We postulated that idiopathic rapid-eye-movement (REM) sleep behaviour disorder (IRBD) represents the prodromal phase of a Lewy body disorder and that, with sufficient follow-up, most cases would eventually be diagnosed with a clinical defined Lewy body disorder, such as Parkinson's disease (PD) or dementia with Lewy bodies (DLB).Patients from (...) showing widespread Lewy bodies in the brain, and α-synuclein aggregates in the peripheral autonomic nervous system in one case. In these three patients, neuronal loss and Lewy pathology (α-synuclein-containing Lewy bodies and Lewy neurites) were found in the brainstem nuclei that regulate REM sleep atonia.Most IRBD individuals from our cohort developed a Lewy body disorder with time. Patients who remained disease-free at follow-up showed markers of increased short-term risk for developing PD and DLB

2013 Lancet Neurology

229. Sleep stage sequence analysis of sleep onset REM periods in the hypersomnias. (Abstract)

Sleep stage sequence analysis of sleep onset REM periods in the hypersomnias. The Multiple Sleep Latency Test (MSLT) remains an important diagnostic tool in the diagnosis of hypersomnias. However, a positive MSLT may be found in other sleep disorders, such as behaviourally induced inadequate sleep syndrome (BIISS). It has been demonstrated that in sleep onset rapid eye movement (SOREM) periods in BIISS, REM sleep tends to arise from stage 2 sleep (non-REM (NREM) 2), rather than stage 1 sleep (...) (NREM1), as in narcolepsy.We performed sleep stage sequence analysis on 127 patients with nocturnal polysomnography and MSLT, including 25 with narcolepsy with cataplexy (N+C), 41 with narcolepsy without cataplexy (N-C), 21 with idiopathic hypersomnia with long sleep time (IHL), 20 with BIISS and 20 with periodic limb movement disorder (PLMD). 537 naps were recorded, containing 176 SOREM periods.All SOREM periods in the IHL, BIISS and PLMD groups arose from NREM2 sleep, 75% of those in N+C arose from

2012 Neurosurgery and Psychiatry

230. Sleep Disorders (PDQ®): Health Professional Version

were identified as having a more severe sleep disorder were significantly younger, had more comorbidities, had a lower performance status, and experienced hot flashes. Risk Factors for Sleep Disorders Disease factors, including paraneoplastic syndromes with increased steroid production; and symptoms associated with tumor invasion (e.g., obstruction, pain, fever, shortness of breath, pruritus, and fatigue). Treatment factors, including symptoms related to surgery (e.g., pain, frequent monitoring (...) , and/or hospitalization). Perception of significant others as to the quantity and quality of patient’s sleep. Family history of sleep disorders. References American Academy of Sleep Medicine: The International Classification of Sleep Disorders: Diagnostic & Coding Manual. 2nd ed. Westchester, Ill: American Academy of Sleep Medicine, 2005. Perlis ML, Jungquist C, Smith MT, et al.: Cognitive Behavioral Treatment of Insomnia: A Session-by-Session Guide. New York, NY: Springer Science+Business Media LLC, 2008. Bastien CH

2016 PDQ - NCI's Comprehensive Cancer Database

231. REM Sleep Regulating Mechanisms in the Cholinergic Cell Compartment of the Brainstem Full Text available with Trip Pro

REM Sleep Regulating Mechanisms in the Cholinergic Cell Compartment of the Brainstem Rapid eye movement (REM) sleep is a highly evolved yet paradoxical behavioral state (highly activated brain in a paralyzed body) in mammalian species. Since the discovery of REM sleep and its physiological distinction from other sleep states1, a vast number of studies in neurosciences have been dedicated toward understanding the mechanisms and functions of this behavioral state. Collectively, studies have shown (...) that each of the physiological events that characterize the behavioral state of REM sleep is executed by distinct cell groups located in the brainstem. These cell groups are discrete components of a widely distributed network, rather than a single REM sleep center. The final activity within each of these executive cell groups is controlled by the ratio of cholinergic neurotransmission emanating from the pedunculopontine tegmentum (PPT) to aminergic neurotransmission emanating from the locus coeruleus

2013 Indian journal of sleep medicine

232. The Basolateral Amygdala Can Mediate the Effects of Fear Memory on Sleep Independently of Fear Behavior and the Peripheral Stress Response Full Text available with Trip Pro

The Basolateral Amygdala Can Mediate the Effects of Fear Memory on Sleep Independently of Fear Behavior and the Peripheral Stress Response Fear conditioning associated with inescapable shock training (ST) and fearful context re-exposure (CR) alone can produce significant behavioral fear, a stress response and alterations in subsequent REM sleep. These alterations may vary among animals and are mediated by the basolateral nucleus of the amygdala (BLA). Here, we used the GABAA agonist, muscimol (...) (Mus), to inactivate BLA prior to CR and examined the effects on sleep, freezing and stress-induced hyperthermia (SIH). Wistar rats (n=28) were implanted with electrodes for recording sleep, data loggers for recording core body temperature, and with cannulae aimed bilaterally into BLA. After recovery, the animals were habituated to the injection procedure and baseline sleep was recorded. On experimental day 1, rats received ST (20 footshocks, 0.8mA, 0.5s duration, 60s interstimulus interval

2016 Neurobiology of learning and memory

233. The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health

of SWL-exposure on the structure and quality of sleep, cognitive functioning in Continous Performance Test (CPT III), emotional state, and physiological, variables (melatonin secretion levels and body temperature) that were not tested in previous studies. Condition or disease Intervention/treatment Phase Sleep Emotion Other: No intervention- base line Other: Acute Other: Chronic Not Applicable Detailed Description: The investigators will examine whether there is a difference between one-time (...) The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record

2016 Clinical Trials

234. Effects of Optogenetic inhibition of BLA on Sleep Brief Optogenetic Inhibition of the Basolateral Amygdala in Mice Alters Effects of Stressful Experiences on Rapid Eye Movement Sleep Full Text available with Trip Pro

reduction in REM after IS and produced a significant overall increase in REM. Moreover, upon exposure to the shock context alone, mice receiving peri-shock inhibition of BLA during training showed increased REM without altered freezing (an index of fear memory) or stress-induced hyperthermia (an index of acute stress response). Inhibition of BLA during REM under freely sleeping conditions enhanced REM only when body temperature was high, suggesting the effect was influenced by stress. Peri-shock (...) inhibition of BLA also led to elevated c-Fos expression in the central nucleus of the amygdala and mPFC and differentially altered c-Fos activity in the selected brain stem regions.Glutamatergic cells in BLA can modulate the effects of stress on REM and can mediate effects of fear memory on sleep that can be independent of behavioral fear.© Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail

2017 Sleep

235. Pharmacotherapy for sleep bruxism. (Abstract)

Pharmacotherapy for sleep bruxism. Sleep bruxism is an oral activity characterized by involuntary teeth grinding or clenching during sleep. Several forms of treatment have been proposed for this disorder, including behavioural, dental and pharmacological strategies.To evaluate the effectiveness and safety of pharmacological therapy for the treatment of sleep bruxism compared with other drugs, no treatment or placebo.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (Issue (...) (sleep duration, masseteric EMG activity per minute and pain intensity) in a meta-analysis for comparison of amitriptyline with placebo. The results for most comparisons were uncertain because of statistical imprecision. One study reported that clonidine reduced rapid eye movement (REM) sleep stage and increased the second stage of sleep. However, results for other sleep-related outcomes with clonidine were uncertain. Adverse effects were frequent in people who took amitriptyline (5/10 had drowsiness

2014 Cochrane

236. Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson's disease: A prospective study. Full Text available with Trip Pro

Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson's disease: A prospective study. One of the most devastating nonmotor manifestations of PD is dementia. There are few established predictors of dementia in PD. In numerous cross-sectional studies, patients with rapid eye movement (REM) sleep behavior disorder (RBD) have increased cognitive impairment on neuropsychological testing, but no prospective studies have assessed whether RBD can predict Parkinson's dementia. PD (...) , and 15 did not. Four years after the initial evaluation, 48% with RBD developed dementia, compared to 0% of those without (P-adjusted = 0.014). All 13 patients who developed dementia had mild cognitive impairment on baseline examination. Baseline REM sleep atonia loss predicted development of dementia (% tonic REM = 73.2 ± 26.7 with dementia, 40.8 ± 34.5 without; P = 0.029). RBD at baseline also predicted the new development of hallucinations and cognitive fluctuations. In this prospective study, RBD

2012 Movement Disorders

237. A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015. Full Text available with Trip Pro

. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005 to 2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. We discuss the epidemiology, etiology, clinical implications, associated (...) A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015. Sleep disorders are among the most common non-motor manifestations in Parkinson's disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications

2016 Sleep medicine reviews

238. Pharmacological interventions for daytime sleepiness and sleep disorders in Parkinson's disease: Systematic review and meta-analysis. (Abstract)

Pharmacological interventions for daytime sleepiness and sleep disorders in Parkinson's disease: Systematic review and meta-analysis. Daytime sleepiness and sleep disorders are frequently reported in Parkinson's disease (PD). However, their impact on quality of life has been underestimated and few clinical trials have been performed.We aimed to assess the efficacy and safety of pharmacological interventions for daytime sleepiness and sleep disorders in PD.Systematic review of randomized (...) with caffeine was associated with a non-significant improvement of 1.71 points in ESS (95% CI, - 3.57 to 0.13). The six remaining trials assessed interventions for insomnia and REM sleep Behaviour Disorder (RBD). Single study results suggest that doxepin and YXQN granules might be efficacious, while pergolide may be deleterious for insomnia and that rivastigmine may be used to treat RBD in PD patients. However, there is insufficient evidence to support or refute the efficacy of any of these interventions

2016 Parkinsonism & related disorders

239. An Official ATS Statement: Impact of Mild Obstructive Sleep Apnea in Adults

It is unclear whether there is an association between mild OSA and increased incidence of cardiovascular events. It is unclear whether there is a differential impact of mild OSA on hypertension and cardiovascular complications in high-risk populations (e.g., individuals with underlying cardiovascular disease or multiple comorbid conditions) as well as those who are sleepy. d Mild OSA islikely not associated with an increase in stroke in subjects from the general population or patients referred for sleep (...) . There was no evidence from a single study that treatment of mild OSA reduces all-cause mortality. d The task force members identi?ed speci?c research gaps and made recommendations to address these gaps in knowledge. Introduction OSA is a major public health problem that is characterized by repetitive obstruction of the upper airway resulting in oxygen desaturation and/or arousals from sleep. The International Classi?cation of Sleep Disorders (1) de?nes OSA as the occurrence of predominantly obstructive apneas

2016 American Thoracic Society

240. Cognitive Behavioural Therapy for the Treatment of Late Life Depression

. It will test the hypothesis, that LLD-specific cognitive behavioural therapy (CBT) is superior to unspecific supportive intervention (SUI) with regard to reducing symptoms of depression over the course of 6 months. Secondary goals are to test the efficacy of LLD-CBT in comparison with SUI on patient reported outcome in major depressive disorders (PRO-MDD), anxiety, cognition, quality of life, overall health status, sleep and global clinical impression. Condition or disease Intervention/treatment Phase Late (...) (ESS). It is a self-rating scale including 8 Items rated on a 4-point Likert scale. The total score ranges from 0 to 24. Higher values represent worse outcome. Change of REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ)Score [ Time Frame: 10 weeks ] A secondary outcome measure is the change in REM sleep behavior from baseline to week 10 measured by the 10-item REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ). It is a self-rating scale including 10 Items in a yes/no format

2018 Clinical Trials

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