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REM Sleep Behavior Disorder

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181. Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: A multicenter study. (PubMed)

Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: A multicenter study. To assess whether risk factors for Parkinson disease and dementia with Lewy bodies increase rate of defined neurodegenerative disease in idiopathic rapid eye movement (REM) sleep behavior disorder (RBD).Twelve centers administered a detailed questionnaire assessing risk factors for neurodegenerative synucleinopathy to patients with idiopathic RBD. Variables included demographics (...) in Parkinson disease or sleep disorders. Medication exposures and medical history were similar between groups. Autonomic and motor symptoms were more common among those who converted. Risk factors for primary dementia and parkinsonism were generally similar, except for a notably higher clonazepam use in dementia convertors (OR = 2.6).Patients with idiopathic RBD are at very high risk of neurodegenerative synucleinopathy. Risk factor profiles between convertors and nonconvertors have both important

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2015 Annals of Neurology

182. Insulinoma Masquerading as Rapid Eye Movement Sleep Behavior Disorder: Case Series and Literature Review. (PubMed)

Insulinoma Masquerading as Rapid Eye Movement Sleep Behavior Disorder: Case Series and Literature Review. Insulinoma is a rare endocrine tumor that can cause a wide variety of symptoms, including abnormal nocturnal behavior. We report on 3 patients with insulinoma who presented with abnormal nocturnal behavior and injury during sleep, which simulated rapid eye movement (REM) sleep behavior disorder (RBD). In case 1, the fasting glucose level was 15  mg/dL, and insulin levels were elevated (15 (...) ineffective. Polysomnography showed no evidence of REM sleep without atonia in any of the 3 patients. No patient remembered any events that occurred during sleep. When a patient manifests abnormal behavior during the night and early morning, glucose monitoring should be performed, especially during the night and early morning. Clinicians should be aware that although insulinomas are rare, they can mimic parasomnias, such as RBD.

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2015 Medicine

183. REM Sleep at its Core – Circuits, Neurotransmitters, and Pathophysiology (PubMed)

tegmentum in the brainstem. Determining how these circuits interact with the SubC is important because breakdown in their communication is hypothesized to underlie narcolepsy/cataplexy and REM sleep behavior disorder (RBD). This review synthesizes our current understanding of mechanisms generating healthy REM sleep and how dysfunction of these circuits contributes to common REM sleep disorders such as cataplexy/narcolepsy and RBD. (...) REM Sleep at its Core – Circuits, Neurotransmitters, and Pathophysiology Rapid eye movement (REM) sleep is generated and maintained by the interaction of a variety of neurotransmitter systems in the brainstem, forebrain, and hypothalamus. Within these circuits lies a core region that is active during REM sleep, known as the subcoeruleus nucleus (SubC) or sublaterodorsal nucleus. It is hypothesized that glutamatergic SubC neurons regulate REM sleep and its defining features such as muscle

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2015 Frontiers in neurology

184. Family history of idiopathic REM behavior disorder: A multicenter case-control study. (PubMed)

Family history of idiopathic REM behavior disorder: A multicenter case-control study. To compare the frequency of proxy-reported REM sleep behavior disorder (RBD) among relatives of patients with polysomnogram-diagnosed idiopathic RBD (iRBD) in comparison to controls using a large multicenter clinic-based cohort.A total of 316 patients with polysomnography-confirmed iRBD were recruited from 12 RBD study group centers, along with 316 controls matched on sex and age group. All subjects completed

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2013 Neurology

185. REM Theta Activity Enhances Inhibitory Control in Typically Developing Children but not Children with ADHD Symptoms (PubMed)

REM Theta Activity Enhances Inhibitory Control in Typically Developing Children but not Children with ADHD Symptoms Sleep disturbances impair cognitive functioning in typically developing populations. Children with attention-deficit/hyperactivity disorder (ADHD), a disorder characterized by impaired inhibitory control and attention, commonly experience sleep disturbances. Whether inhibitory impairments are related to sleep deficits in children with ADHD is unknown. Children with ADHD (n = 18; M (...) in children with ADHD compared to typically developing children, it was functionally insignificant. Neither inhibitory control nor sustained attention was improved following overnight sleep in children with ADHD symptoms, and neither of these behaviors was associated with REM theta activity in this group. Taken together, these results indicate that elevated REM theta activity may be functionally related to ADHD symptomology, possibly reflecting delayed cortical maturation.

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2017 Experimental Brain Research

186. The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health

The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record (...) Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal

2016 Clinical Trials

187. Surface EMG activity during REM sleep in Parkinson’s disease correlates with disease severity (PubMed)

Surface EMG activity during REM sleep in Parkinson’s disease correlates with disease severity Over 40% of individuals with Parkinson's disease (PD) have rapid eye movement sleep behavior disorder (RBD). This is associated with excessive sustained (tonic) or intermittent (phasic) muscle activity instead of the muscle atonia normally seen during REM sleep. We examined characteristics of manually-quantitated surface EMG activity in PD to ascertain whether the extent of muscle activity during REM (...) sleep is associated with specific clinical features and measures of disease severity.In a convenience sample of outpatients with idiopathic PD, REM sleep behavior disorder was diagnosed based on clinical history and polysomnogram, and severity was measured using the RBD sleep questionnaire. Surface EMG activity in the mentalis, extensor muscle group of the forearms, and anterior tibialis was manually quantitated. Percentage of REM time with excessive tonic or phasic muscle activity was calculated

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2014 Parkinsonism & related disorders

188. The Role of Weight Management in the Treatment of Adult Obstructive Sleep Apnea Guideline

practice guideline is to 1)reviewthe evidence of the impact of weight-loss interventions on OSA severity, quality of life, and associated comorbidities and 2) provide speci?c recommendations for weight management in adult patients with OSA who are overweight or obese, as de?ned as a body mass index (BMI) greater than or equal to 25 kg/m 2 .A panel of sleep and pulmonary physicians, weight management experts, and behavioral scientists developed seven therapy-related questions, reviewed the relevant (...) , none provides detailed recommendations about how to achieve weight loss. Perhaps because of the absence of speci?c clinically relevant recommendations, weight-loss strategies have not been implemented systematically in the routine care of patients with OSA who are overweight or obese. To address this knowledge gap, the American Thoracic Society (ATS) commissioned a panel of pulmonary and sleep medicine specialists, weight management experts, behavioral scientists, and patients to summarize

2018 American Thoracic Society

189. Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD. 36 Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, Yale University, New Haven, CT. 37 Department of Anesthesiology and Critical Care, Grenoble Alpes University Hospital, Grenoble, France. 38 School of Nursing, University of California San Francisco, San Francisco, CA. 39 Department of Surgery, University of Washington, Seattle, WA. 40 Department of Critical Care and Perioperative Medicine, School (...) Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU Clinical Practice Guidelines for the Prevention and Manageme... : Critical Care Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me

2018 Society of Critical Care Medicine

190. Polysomnography for Sleep-Disordered Breathing Prior to Tonsillectomy in Children

: peter.roland@utsouthwestern.eduRoland et al S3 Background and Significance SDB represents a spectrum of sleep disorders ranging in severity from snoring to OSA. In children, the estimated prevalence for habitual snoring is 10% to 12%, whereas the estimated preva- lence of OSA is only 1% to 3 %. 3,9,10 In addition to nighttime symptoms, SDB also affects daytime behavior, including school performance, neurocognitive function, and quality of life. 11-13 Upper airway obstruction caused by the tonsils, adenoid (...) on diagnostic studies with limitations and a preponderance of benefit over harm. Abbreviations: OSA, obstructive sleep apnea; PSG, polysomnography; SDB, sleep-disordered breathing.S4 Otolaryngology–Head and Neck Surgery 145(1S) arousal without desaturation, (2) how long the patient slept, (3) carbon dioxide elevation, (4) prolonged flow limitation without discrete desaturation, or (5) whether they achieved rapid eye movement (REM) sleep (the period when respiratory events are most common). 21 Methods

2011 American Academy of Otolaryngology - Head and Neck Surgery

191. CPG on sleep disorders in childhood and adolescence in primary care

ON SLEEP DISORDERS IN CHILDHOOD AND ADOLESCENCE IN PRIMARY CARE 11 Acknowledgements Mª Dolores Gómez Fernández, Health Technologies Assessment Unit (UETS), administrative support and editorial duties. Collaborating Societies This CPG has the endorsement of the following societies: Spanish Association of Paediatrics, AEP. Spanish Association of Primary Care Paediatrics, AEPap. Spanish Association of Behavioral Psychology, AEPC. Spanish Sleep Association, ASENARCO. Spanish Society of Adolescent Medicine (...) in an interview with parents/caretakers/children/adolescents? 6. What tests or tools can we use for an overall assessment of child and adolescent sleep in Primary Care Health Centers? 7. What are the complementary tests to keep in mind? 8. What are the differential diagnoses to keep in mind? 9. Are there preventive strategies for sleep disorders? DEFINITION, DIAGNOSIS AND TREATMENT OF SLEEP DISORDERS 10. What is insomnia due to inadequate sleep hygiene? 11. What is behavioral insomnia? 12. What

2011 GuiaSalud

192. Suvorexant and Sleep's Benefits to Therapeutic Exposure for Posttraumatic Stress Disorder

of insomnia. Suvorexant reduced WASO and latency to persistent sleep and increased SWS and REM sleep in humans with insomnia. In addition, administrations of orexin-A increased anxiety-like behaviors in rodents, and administrations of an orexin receptor-1 antagonist to mice facilitated extinction of conditioned fear, an animal model of recovery from PTSD and anxiety disorders. Objective: To examine effects of blocking the orexin system with suvorexant after WNE on sleep, PTSD symptoms, and intersession (...) ) on sleep, PTSD symptoms, and intersession habituation. Condition or disease Intervention/treatment Phase Posttraumatic Stress Disorder Drug: suvorexant Other: placebo Phase 4 Detailed Description: Cognitive behavioral therapies (CBT) that include exposure to trauma memories are considered first line treatments for PTSD. However, approximately 1/3 of patients who complete CBT for PTSD do not achieve remission, and hyperarousal symptoms including sleep disturbances are less responsive to CBT than other

2016 Clinical Trials

193. A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015. (PubMed)

. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005 to 2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. We discuss the epidemiology, etiology, clinical implications, associated (...) A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015. Sleep disorders are among the most common non-motor manifestations in Parkinson's disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications

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2016 Sleep medicine reviews

194. Neuromelanin-sensitive imaging in patients with idiopathic rapid eye movement sleep behaviour disorder (PubMed)

of Neurology and Centre for Sleep Medicine, Mayo Clinic, Rochester, Minnesota, USA. Kantarci Kejal K Department of Diagnostic Radiology, Mayo Clinic, Rochester, Minnesota, USA. eng P50 AG044170 AG NIA NIH HHS United States R01 AG040042 AG NIA NIH HHS United States Journal Article Research Support, N.I.H., Extramural Comment England Brain 0372537 0006-8950 AIM IM Brain. 2016 Apr;139(Pt 4):1180-8 26920675 Female Humans Locus Coeruleus pathology physiopathology Male REM Sleep Behavior Disorder diagnosis (...) Neuromelanin-sensitive imaging in patients with idiopathic rapid eye movement sleep behaviour disorder 27012490 2016 08 19 2018 12 02 1460-2156 139 Pt 4 2016 Apr Brain : a journal of neurology Brain Neuromelanin-sensitive imaging in patients with idiopathic rapid eye movement sleep behaviour disorder. 1005-7 10.1093/brain/aww030 Boeve Bradley F BF Department of Neurology and Centre for Sleep Medicine, Mayo Clinic, Rochester, Minnesota, USA bboeve@mayo.edu. St Louis Erik K EK Department

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2016 Brain

195. Sleep Disturbances in Posttraumatic Stress Disorder: Updated Review and Implications for Treatment (PubMed)

Sleep Disturbances in Posttraumatic Stress Disorder: Updated Review and Implications for Treatment Sleep disturbances are common in adults with PTSD and range from insomnia and nightmares to periodic leg movements and disruptive nocturnal behaviors. Together these findings suggest profound disturbances in rapid eye movement (REM) and non-REM (NREM) sleep, although there is a lack of consensus regarding a distinct profile of objective sleep disturbances associated with PTSD. Prospective (...) , longitudinal studies have established that sleep disturbances represent a risk factor for the development and course of PTSD, suggesting that sleep is an important neurobiological mechanism in the etiology and maintenance of this disorder. This research highlights the importance of early identification and treatment of sleep disturbances in at-risk and trauma exposed populations. A number of psychological and pharmacological treatments are effective at treating sleep disturbances in PTSD. Additional

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2016 Psychiatric Annals

196. Memory consolidation in sleep disorders. (PubMed)

in the consolidation of declarative and procedural information. On the other hand, patients with parasomnias, such as sleep-walking, night terrors and rapid eye movement (REM) behavior disorder, do not present any memory impairment. These studies suggest that only sleep disorders characterized by increased post-learning arousal and disrupted sleep architecture seem to be associated with offline memory consolidation issues. Such impairments, arising already in childhood, may potentially affect the development (...) Memory consolidation in sleep disorders. In recent years sleep-related memory consolidation has become a central topic in the sleep research field. Several studies have shown that in healthy individuals sleep promotes memory consolidation. Notwithstanding this, the consequences of sleep disorders on offline memory consolidation remain poorly investigated. Research studies indicate that patients with insomnia, obstructive sleep apnea, and narcolepsy often exhibit sleep-related impairment

2016 Sleep medicine reviews

197. Sleep disturbances in Parkinson's disease: the contribution of dopamine in REM sleep regulation. (PubMed)

system in the regulation of rapid eye movement (REM) sleep. The presence of an REM sleep behavior disorder in patients with PD might reflect the early involvement of dopaminergic neurotransmission in REM sleep-related structures. Therefore, it has been suggested that these structures are affected by an imbalance of dopamine levels. Several studies have demonstrated that neurons in the substantia nigra pars compacta (SNpc) and in the ventral tegmental area (VTA) are active during REM sleep (...) Sleep disturbances in Parkinson's disease: the contribution of dopamine in REM sleep regulation. Nearly all patients with Parkinson's disease (PD) have sleep disturbances. While it has been suggested that these disturbances involve a dopaminergic component, the specific mechanisms that contribute to this behavior are far from being fully understood. In this article, we have reviewed the current understanding of the linkage between sleep and PD, focusing on the participation of the dopaminergic

2013 Sleep medicine reviews

198. Noninvasive Identification of Inspiratory Flow Limitation in Sleep Studies: An Official Workshop Report

. Montserrat and colleagues (6) have demonstrated that the nasal pressure air?ow signal correlates well with pneumotachographic ?ow. Thus, the standardized visual detection of IFL from a nasal cannula pressure signal could enhance the evaluation of sleep-disordered breathing in situations where a low AHI fails to capture suspected risk for health outcomes. The overarching goal of this workshop was to develop an approach to standardizing visual analysis of IFL in the clinical setting, which can be applied (...) to identify the presence or classify severity of IFL, as follows: (1) ?attening of air?ow— supraglottic (or esophageal) pressure relationship (12–17); (2) presence of negative effort dependence (NED) (12, 14–16); (3) the shape or function of the air?ow–time curve (1, 14, 15, 18, 19); (4) increased inspiratory duty cycle (17); (5) high-frequency ?uctuations/oscillations; and (6) air?ow–effort asynchrony (16). All studies were performed during non–rapid eye movement (REM) sleep (one study included REM, one

2017 American Thoracic Society

199. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder

.2012.07.008. PMID: 22921765. 32. Ivarsson D, Blom M, Hesser H, et al. Guided internet-delivered cognitive behavior therapy for post-traumatic stress disorder: a randomized controlled trial. Internet Interv. 2014 March;1(1):33-40. doi: 10.1016/j.invent.2014.03.002. 33. Kangas M, Milross C, Taylor A, et al. A pilot randomized controlled trial of a brief early intervention for reducing posttraumatic stress disorder, anxiety and depressive symptoms in newly diagnosed head and neck cancer patients (...) and PCORI.) AHRQ Publication No. 18-EHC011-EF. PCORI Publication No. 2018-SR-01. Rockville, MD: Agency for Healthcare Research and Quality; May 2018. doi: 10.23970/AHRQEPCCER207. 43. Ahmadpanah M, Sabzeiee P, Hosseini SM, et al. Comparing the effect of prazosin and hydroxyzine on sleep quality in patients suffering from posttraumatic stress disorder. Neuropsychobiology. 2014 Jul;69(4):235- 42. doi: 10.1159/000362243. PMID: 24993832. 44. Akuchekian S, Amanat S. The comparison of topiramate and placebo

2019 Effective Health Care Program (AHRQ)

200. Guidance on the clinical management of anxiety disorders, specifically focusing on diagnosis and treatment strategies

these guidelines, we considered two important concepts. First, that all disorders exist on a dimension from subthreshold to severe cases. While guidelines apply to above-threshold cases, they are applicable to people with subthreshold cases who are at risk of developing a First published in the Australian and New Zealand Journal of Psychiatry 2018, Vol. 52(12) 1109-1172.1116 ANZJP Articles threshold disorder (Helzer et al., 2009). Second, that there are clusters of mental disorders that share causes and rem (...) Guidance on the clinical management of anxiety disorders, specifically focusing on diagnosis and treatment strategies Objective: To provide practical clinical guidance for the treatment of adults with panic disorder, social anxiety disorder and generalised anxiety disorder in Australia and New Zealand. Method: Relevant systematic reviews and meta-analyses of clinical trials were identified by searching PsycINFO, Med- line, Embase and Cochrane databases. Additional relevant studies were

2018 Royal Australian and New Zealand College of Psychiatrists

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