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REM Sleep Behavior Disorder

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181. Family history of idiopathic REM behavior disorder: A multicenter case-control study. (PubMed)

Family history of idiopathic REM behavior disorder: A multicenter case-control study. To compare the frequency of proxy-reported REM sleep behavior disorder (RBD) among relatives of patients with polysomnogram-diagnosed idiopathic RBD (iRBD) in comparison to controls using a large multicenter clinic-based cohort.A total of 316 patients with polysomnography-confirmed iRBD were recruited from 12 RBD study group centers, along with 316 controls matched on sex and age group. All subjects completed

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2013 Neurology

182. REM Theta Activity Enhances Inhibitory Control in Typically Developing Children but not Children with ADHD Symptoms (PubMed)

REM Theta Activity Enhances Inhibitory Control in Typically Developing Children but not Children with ADHD Symptoms Sleep disturbances impair cognitive functioning in typically developing populations. Children with attention-deficit/hyperactivity disorder (ADHD), a disorder characterized by impaired inhibitory control and attention, commonly experience sleep disturbances. Whether inhibitory impairments are related to sleep deficits in children with ADHD is unknown. Children with ADHD (n = 18; M (...) in children with ADHD compared to typically developing children, it was functionally insignificant. Neither inhibitory control nor sustained attention was improved following overnight sleep in children with ADHD symptoms, and neither of these behaviors was associated with REM theta activity in this group. Taken together, these results indicate that elevated REM theta activity may be functionally related to ADHD symptomology, possibly reflecting delayed cortical maturation.

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2017 Experimental Brain Research

183. The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health

The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record (...) Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal

2016 Clinical Trials

184. Surface EMG activity during REM sleep in Parkinson’s disease correlates with disease severity (PubMed)

Surface EMG activity during REM sleep in Parkinson’s disease correlates with disease severity Over 40% of individuals with Parkinson's disease (PD) have rapid eye movement sleep behavior disorder (RBD). This is associated with excessive sustained (tonic) or intermittent (phasic) muscle activity instead of the muscle atonia normally seen during REM sleep. We examined characteristics of manually-quantitated surface EMG activity in PD to ascertain whether the extent of muscle activity during REM (...) sleep is associated with specific clinical features and measures of disease severity.In a convenience sample of outpatients with idiopathic PD, REM sleep behavior disorder was diagnosed based on clinical history and polysomnogram, and severity was measured using the RBD sleep questionnaire. Surface EMG activity in the mentalis, extensor muscle group of the forearms, and anterior tibialis was manually quantitated. Percentage of REM time with excessive tonic or phasic muscle activity was calculated

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2014 Parkinsonism & related disorders

185. The Role of Weight Management in the Treatment of Adult Obstructive Sleep Apnea Guideline

practice guideline is to 1)reviewthe evidence of the impact of weight-loss interventions on OSA severity, quality of life, and associated comorbidities and 2) provide speci?c recommendations for weight management in adult patients with OSA who are overweight or obese, as de?ned as a body mass index (BMI) greater than or equal to 25 kg/m 2 .A panel of sleep and pulmonary physicians, weight management experts, and behavioral scientists developed seven therapy-related questions, reviewed the relevant (...) , none provides detailed recommendations about how to achieve weight loss. Perhaps because of the absence of speci?c clinically relevant recommendations, weight-loss strategies have not been implemented systematically in the routine care of patients with OSA who are overweight or obese. To address this knowledge gap, the American Thoracic Society (ATS) commissioned a panel of pulmonary and sleep medicine specialists, weight management experts, behavioral scientists, and patients to summarize

2018 American Thoracic Society

186. Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD. 36 Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, Yale University, New Haven, CT. 37 Department of Anesthesiology and Critical Care, Grenoble Alpes University Hospital, Grenoble, France. 38 School of Nursing, University of California San Francisco, San Francisco, CA. 39 Department of Surgery, University of Washington, Seattle, WA. 40 Department of Critical Care and Perioperative Medicine, School (...) Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU Clinical Practice Guidelines for the Prevention and Manageme... : Critical Care Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me

2018 Society of Critical Care Medicine

187. Polysomnography for Sleep-Disordered Breathing Prior to Tonsillectomy in Children

: peter.roland@utsouthwestern.eduRoland et al S3 Background and Significance SDB represents a spectrum of sleep disorders ranging in severity from snoring to OSA. In children, the estimated prevalence for habitual snoring is 10% to 12%, whereas the estimated preva- lence of OSA is only 1% to 3 %. 3,9,10 In addition to nighttime symptoms, SDB also affects daytime behavior, including school performance, neurocognitive function, and quality of life. 11-13 Upper airway obstruction caused by the tonsils, adenoid (...) on diagnostic studies with limitations and a preponderance of benefit over harm. Abbreviations: OSA, obstructive sleep apnea; PSG, polysomnography; SDB, sleep-disordered breathing.S4 Otolaryngology–Head and Neck Surgery 145(1S) arousal without desaturation, (2) how long the patient slept, (3) carbon dioxide elevation, (4) prolonged flow limitation without discrete desaturation, or (5) whether they achieved rapid eye movement (REM) sleep (the period when respiratory events are most common). 21 Methods

2011 American Academy of Otolaryngology - Head and Neck Surgery

188. CPG on sleep disorders in childhood and adolescence in primary care

ON SLEEP DISORDERS IN CHILDHOOD AND ADOLESCENCE IN PRIMARY CARE 11 Acknowledgements Mª Dolores Gómez Fernández, Health Technologies Assessment Unit (UETS), administrative support and editorial duties. Collaborating Societies This CPG has the endorsement of the following societies: Spanish Association of Paediatrics, AEP. Spanish Association of Primary Care Paediatrics, AEPap. Spanish Association of Behavioral Psychology, AEPC. Spanish Sleep Association, ASENARCO. Spanish Society of Adolescent Medicine (...) in an interview with parents/caretakers/children/adolescents? 6. What tests or tools can we use for an overall assessment of child and adolescent sleep in Primary Care Health Centers? 7. What are the complementary tests to keep in mind? 8. What are the differential diagnoses to keep in mind? 9. Are there preventive strategies for sleep disorders? DEFINITION, DIAGNOSIS AND TREATMENT OF SLEEP DISORDERS 10. What is insomnia due to inadequate sleep hygiene? 11. What is behavioral insomnia? 12. What

2011 GuiaSalud

189. Suvorexant and Sleep's Benefits to Therapeutic Exposure for Posttraumatic Stress Disorder

of insomnia. Suvorexant reduced WASO and latency to persistent sleep and increased SWS and REM sleep in humans with insomnia. In addition, administrations of orexin-A increased anxiety-like behaviors in rodents, and administrations of an orexin receptor-1 antagonist to mice facilitated extinction of conditioned fear, an animal model of recovery from PTSD and anxiety disorders. Objective: To examine effects of blocking the orexin system with suvorexant after WNE on sleep, PTSD symptoms, and intersession (...) ) on sleep, PTSD symptoms, and intersession habituation. Condition or disease Intervention/treatment Phase Posttraumatic Stress Disorder Drug: suvorexant Other: placebo Phase 4 Detailed Description: Cognitive behavioral therapies (CBT) that include exposure to trauma memories are considered first line treatments for PTSD. However, approximately 1/3 of patients who complete CBT for PTSD do not achieve remission, and hyperarousal symptoms including sleep disturbances are less responsive to CBT than other

2016 Clinical Trials

190. A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015. (PubMed)

. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005 to 2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. We discuss the epidemiology, etiology, clinical implications, associated (...) A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015. Sleep disorders are among the most common non-motor manifestations in Parkinson's disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications

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2016 Sleep medicine reviews

191. Neuromelanin-sensitive imaging in patients with idiopathic rapid eye movement sleep behaviour disorder (PubMed)

of Neurology and Centre for Sleep Medicine, Mayo Clinic, Rochester, Minnesota, USA. Kantarci Kejal K Department of Diagnostic Radiology, Mayo Clinic, Rochester, Minnesota, USA. eng P50 AG044170 AG NIA NIH HHS United States R01 AG040042 AG NIA NIH HHS United States Journal Article Research Support, N.I.H., Extramural Comment England Brain 0372537 0006-8950 AIM IM Brain. 2016 Apr;139(Pt 4):1180-8 26920675 Female Humans Locus Coeruleus pathology physiopathology Male REM Sleep Behavior Disorder diagnosis (...) Neuromelanin-sensitive imaging in patients with idiopathic rapid eye movement sleep behaviour disorder 27012490 2016 08 19 2018 12 02 1460-2156 139 Pt 4 2016 Apr Brain : a journal of neurology Brain Neuromelanin-sensitive imaging in patients with idiopathic rapid eye movement sleep behaviour disorder. 1005-7 10.1093/brain/aww030 Boeve Bradley F BF Department of Neurology and Centre for Sleep Medicine, Mayo Clinic, Rochester, Minnesota, USA bboeve@mayo.edu. St Louis Erik K EK Department

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2016 Brain

192. Sleep Disturbances in Posttraumatic Stress Disorder: Updated Review and Implications for Treatment (PubMed)

Sleep Disturbances in Posttraumatic Stress Disorder: Updated Review and Implications for Treatment Sleep disturbances are common in adults with PTSD and range from insomnia and nightmares to periodic leg movements and disruptive nocturnal behaviors. Together these findings suggest profound disturbances in rapid eye movement (REM) and non-REM (NREM) sleep, although there is a lack of consensus regarding a distinct profile of objective sleep disturbances associated with PTSD. Prospective (...) , longitudinal studies have established that sleep disturbances represent a risk factor for the development and course of PTSD, suggesting that sleep is an important neurobiological mechanism in the etiology and maintenance of this disorder. This research highlights the importance of early identification and treatment of sleep disturbances in at-risk and trauma exposed populations. A number of psychological and pharmacological treatments are effective at treating sleep disturbances in PTSD. Additional

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2016 Psychiatric Annals

193. Memory consolidation in sleep disorders. (PubMed)

in the consolidation of declarative and procedural information. On the other hand, patients with parasomnias, such as sleep-walking, night terrors and rapid eye movement (REM) behavior disorder, do not present any memory impairment. These studies suggest that only sleep disorders characterized by increased post-learning arousal and disrupted sleep architecture seem to be associated with offline memory consolidation issues. Such impairments, arising already in childhood, may potentially affect the development (...) Memory consolidation in sleep disorders. In recent years sleep-related memory consolidation has become a central topic in the sleep research field. Several studies have shown that in healthy individuals sleep promotes memory consolidation. Notwithstanding this, the consequences of sleep disorders on offline memory consolidation remain poorly investigated. Research studies indicate that patients with insomnia, obstructive sleep apnea, and narcolepsy often exhibit sleep-related impairment

2016 Sleep medicine reviews

194. Sleep disturbances in Parkinson's disease: the contribution of dopamine in REM sleep regulation. (PubMed)

system in the regulation of rapid eye movement (REM) sleep. The presence of an REM sleep behavior disorder in patients with PD might reflect the early involvement of dopaminergic neurotransmission in REM sleep-related structures. Therefore, it has been suggested that these structures are affected by an imbalance of dopamine levels. Several studies have demonstrated that neurons in the substantia nigra pars compacta (SNpc) and in the ventral tegmental area (VTA) are active during REM sleep (...) Sleep disturbances in Parkinson's disease: the contribution of dopamine in REM sleep regulation. Nearly all patients with Parkinson's disease (PD) have sleep disturbances. While it has been suggested that these disturbances involve a dopaminergic component, the specific mechanisms that contribute to this behavior are far from being fully understood. In this article, we have reviewed the current understanding of the linkage between sleep and PD, focusing on the participation of the dopaminergic

2013 Sleep medicine reviews

195. Noninvasive Identification of Inspiratory Flow Limitation in Sleep Studies: An Official Workshop Report

. Montserrat and colleagues (6) have demonstrated that the nasal pressure air?ow signal correlates well with pneumotachographic ?ow. Thus, the standardized visual detection of IFL from a nasal cannula pressure signal could enhance the evaluation of sleep-disordered breathing in situations where a low AHI fails to capture suspected risk for health outcomes. The overarching goal of this workshop was to develop an approach to standardizing visual analysis of IFL in the clinical setting, which can be applied (...) to identify the presence or classify severity of IFL, as follows: (1) ?attening of air?ow— supraglottic (or esophageal) pressure relationship (12–17); (2) presence of negative effort dependence (NED) (12, 14–16); (3) the shape or function of the air?ow–time curve (1, 14, 15, 18, 19); (4) increased inspiratory duty cycle (17); (5) high-frequency ?uctuations/oscillations; and (6) air?ow–effort asynchrony (16). All studies were performed during non–rapid eye movement (REM) sleep (one study included REM, one

2017 American Thoracic Society

196. Sleep Disorders (PDQ®): Patient Version

followed by a REM phase. Each cycle lasts about 90 minutes and is repeated 4 to 6 times during 7 to 8 hours of sleep. Sleep disorders affect normal sleep patterns. Normal sleep patterns differ from person to person. The amount of sleep you need to feel rested may be less or more than others need. If sleep is interrupted or does not last long enough, the phases of sleep are not completed and the brain cannot finish all the tasks that help restore the body and mind. There are five major types (...) nervousness, , and a change in the phase of sleep that increases dreaming, including nightmares. This change in REM sleep may be dangerous for patients with or heart conditions. Sleep Disorders in Special Cases Key Points for This Section Patients Who Have Pain In patients with pain that disturbs their sleep, treatment to relieve the pain will be used before sleep are used. Pain , other drugs being taken, and any other health may affect which sleeping medicines are . Older Patients It's normal for older

2014 PDQ - NCI's Comprehensive Cancer Database

197. An Official ATS Statement: Impact of Mild Obstructive Sleep Apnea in Adults

. There was no evidence from a single study that treatment of mild OSA reduces all-cause mortality. d The task force members identi?ed speci?c research gaps and made recommendations to address these gaps in knowledge. Introduction OSA is a major public health problem that is characterized by repetitive obstruction of the upper airway resulting in oxygen desaturation and/or arousals from sleep. The International Classi?cation of Sleep Disorders (1) de?nes OSA as the occurrence of predominantly obstructive apneas (...) , the ESS was greater in the mild OSA group or there was an association between the AHI and ESS (29, 32, 33, 35–39, 65). In one study, no speci?c comparison between mild OSA and no OSA was performed (30). MVA 5 cross-sectional Mean age ranged from45to50yr In 2 studies, there was no relationship between severity of sleep-disordered breathing and accident risk or crash rate (65, 72). In 3 studies comparing mild OSA with no OSA, the MVA risk was increased among individuals with mild OSA (68, 71, 125

2016 American Thoracic Society

198. Scientific Meeting » Sleep and Neurodevelopment Workshop: Electrophysiologic Sleep Phenotyping (ESP)

experience with infant siblings of children with Autism Spectrum Disorder. Clinical Phenomena that affect Sleep EEG interpretation David Gozal, MD reviewed the literature and consensus understanding in the field surrounding the negative effects of sleep disordered breathing (SDB) on neurodevelopment in children, affecting both attention and behavioral regulation in addition to changes in the cardiovascular system and metabolic homeostasis. He also suggested that snoring alone can be used as a reliable (...) cholinergic activity. Pupillometry, pupil-indexed neuromodulation of brain physiology, can be used to sensitively track brain state, changes across sleep and wakefulness, and simple cognitive and behavioral processes. Rodney Samaco, PhD reviewed genetic mouse and rat models and how these animals may be leveraged as tools to reflect various features reminiscent of human neurodevelopmental disorders (NDD). He described how the field is addressing questions of sleep abnormalities in rodent models of rare

2017 NIMH blog

199. Increased REM sleep without atonia in Parkinson disease with freezing of gait. (PubMed)

Increased REM sleep without atonia in Parkinson disease with freezing of gait. The objective of this cross-sectional study was to test the hypothesis that patients with Parkinson disease (PD) and freezing of gait (PD+FOG) would demonstrate sleep disturbances comparable to those seen in patients with REM sleep behavior disorder (RBD) and these changes would be significantly different from those in PD patients without FOG (PD-FOG) and age-matched controls.We conducted overnight polysomnography (...) studies in 4 groups of subjects: RBD, PD-FOG, PD+FOG, and controls. Tonic and phasic muscle activity during REM sleep were quantified using EMG recordings from the chin, compared among study groups, and correlated with disease metrics.There were no significant differences in measures of disease severity, duration, or dopaminergic medications between the PD+FOG and PD-FOG groups. Tonic muscle activity was increased significantly (p < 0.007) in the RBD and PD+FOG groups compared to the PD-FOG

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2013 Neurology

200. A systematic review of the incidence and prevalence of sleep disorders and seizure disorders in multiple sclerosis. (PubMed)

-4.16%). For sleep disorders we evaluated 18 studies; none were population-based. The prevalence ranged from 0-1.6% for narcolepsy, 14.4-57.5% for restless legs syndrome, 2.22-3.2% for REM behavior disorder, and 7.14-58.1% for obstructive sleep apnea.This review suggests that seizure disorders and sleep disorders are common in MS, but highlights gaps in the epidemiological knowledge of these conditions in MS worldwide. Other than central-western Europe and North America, most regions (...) A systematic review of the incidence and prevalence of sleep disorders and seizure disorders in multiple sclerosis. Several studies have suggested that comorbid neurologic disorders are more common than expected in multiple sclerosis (MS).To estimate the incidence and prevalence of comorbid seizure disorders and sleep disorders in persons with MS and to evaluate the quality of studies included.The PUBMED, EMBASE, Web of Knowledge, and SCOPUS databases, conference proceedings, and reference

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2015 Multiple sclerosis (Houndmills, Basingstoke, England)

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