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41. Prevalence and Genetic Diversity of Enterococcus faecalis Isolates from Mineral Water and Spring Water in China (Full text)

isolates were not resistant to 12 kinds of antibiotics (penicillin, ampicillin, linezolid, quinupristin/dalfopristin, vancomycin, gentamicin, streptomycin, ciprofloxacin, levofloxacin, norfloxacin, nitrofurantoin, and tetracycline). Enterobacterial repetitive intergenic consensus-PCR classified 58 isolates and three reference strains into nine clusters with a similarity of 75%. This study is the first to investigate the prevalence of E. faecalis in mineral water and spring water in China. The results

2017 Frontiers in microbiology PubMed

42. Identification of tigecycline- and vancomycin-resistant Staphylococcus aureus strains among patients with urinary tract infection in Iran (Full text)

to assess the in vitro activity of vancomycin, tigecycline, linezolid and quinupristin/dalfopristin against MRSA isolates from UTI patients. Thirty MRSA strains from 54 S. aureus isolates were isolated from patients with UTI. The antimicrobial susceptibility patterns of the strains were determined by the Kirby-Bauer disk diffusion and broth microdilution methods. PCR assays were used to detect the vanA gene. The MRSA isolates resistant to vancomycin were confirmed using the broth microdilution method (...) . The results revealed that the MRSA isolates were 100% susceptible to linezolid and quinupristin/dalfopristin but 93.3% susceptible to vancomycin and tigecycline respectively. The broth microdilution method confirmed two MRSA strains (6.6%) to be resistant to vancomycin and tigecycline. The study identified vancomycin resistance among the MRSA isolates from UTI patients. This vancomycin resistance in MRSA isolates poses a challenge in managing S. aureus infections. Our study's results highlight the need

2017 New Microbes and New Infections PubMed

43. Characterization of Vancomycin Resistant Enterococci in Hospitalized Patients and Role of Gut Colonization (Full text)

patients and their association with gut colonization.Clinically significant isolates of enterococci (n=250) were studied. Species confirmation was done by Polymerase Chain Reaction (PCR). Minimum Inhibitory Concentration (MIC) for vancomycin was determined by E-test. PCR for VanA, VanB and VanC1 gene was done for genotypic characterization. MIC for teicoplanin, linezolid, tigecycline, daptomycin and quinupristin-dalfopristin was determined by E test. Patients with VRE infection were screened for gut (...) was observed among E. faecium. Vancomycin MIC ≥ 2 μg/mL was noted in 63 (25.2%) isolates. Fifty seven isolates showed presence of vanA and vanC1 was detected in six isolates of E. gallinarum. Isolates with VanB genotype was not detected in the present study. MIC50 (μg/mL) for teicoplanin, linezolid, tigecycline, daptomycin and quinupristin-dalfopristrin was 24, 0.75, 0.064, 2 and 0.064 respectively. Resistance to linezolid (1, 1.6%) and tigecycline (2, 3.2%) was rare. Majority (33/47, 70.2%) patients

2017 Journal of clinical and diagnostic research : JCDR PubMed

44. Antimicrobial resistance and prevalence of CvfB, SEK and SEQ genes among Staphylococcus aureus isolates from paediatric patients with bloodstream infections (Full text)

, respectively. However, no resistance to nitrofurantoin, dalfopristin/quinupristin, rifampicin, gentamicin, linezolid or vancomycin was detected. Resistance to erythromycin, clindamycin and tetracycline in the MRSA group was significantly higher than that in the methicillin-susceptible S. aureus (MSSA) group. No significant differences in antimicrobial resistance patterns were noted between two age groups (≤1 year and >1 year). The proportion of S. aureus isolates positive for CvfB, SEQ and SEK was 100

2017 Experimental and therapeutic medicine PubMed

45. Methicillin-resistant Staphylococcus aureus prosthetic aortic valve endocarditis with paravalvular abscess treated with daptomycin. (PubMed)

-resistant S. aureus (MRSA) strains, are the most frequent pathogens causing prosthetic valve endocarditis (PVE). Vancomycin has been the cornerstone of therapy for serious MRSA infections including bacteremia and endocarditis. Clinicians have noted that MRSA bacteremias treated with vancomycin often fail to clear even with prolonged therapy. Persistent or prolonged MRSA bacteremia unresponsive to vancomycin therapy has led to the treatment of these infections by other agents, that is, quinupristin (...) , dalfopristin, linezolid, or daptomycin. These antibiotics have been found particularly useful in treating MRSA bacteremias unresponsive to vancomycin therapy. We report a case of a patient who presented with MRSA PVE complicated by perivalvular aortic abscess with persistent MRSA bacteremia unresponsive to vancomycin therapy. The patient's MRSA bacteremia was cleared with daptomycin therapy (6 mg/kg/d). Because the patient refused surgery, daptomycin therapy was continued in hopes of curing

2017 Heart & Lung

47. Management of Patients with Infections Caused by Methicillin-Resistant Staphylococcus Aureus (Full text)

and daptomycin are present, options may include the following: quinupristin-dalfopristin 7.5 mg/kg/dose IV every 8 h, TMP-SMX 5 mg/kg/dose IV twice daily, linezolid 600 mg PO/IV twice daily, or telavancin 10 mg/kg/dose IV once daily (C-III) . These options may be given as a single agent or in combination with other antibiotics. XI. What is the management of MRSA infections in neonates? Neonatal pustulosis 74. For mild cases with localized disease, topical treatment with mupirocin may be adequate in full-term (...) inhibitors [ ]. Linezolid causes less bone marrow suppression in children than it causes in adults [ ]. The most common adverse events in children are diarrhea, vomiting, loose stools, and nausea [ ]. The linezolid suspension may not be tolerated because of taste and may not be available in some pharmacies. It is considered pregnancy category C. Quinupristin-Dalfopristin. Quinupristin-dalfopristin is a combination of 2 streptogramin antibiotics and inhibits protein synthesis. It is FDA-approved for cSSTI

2011 Infectious Diseases Society of America PubMed

48. Efficacy of ultraviolet C light at sublethal dose in combination with antistaphylococcal antibiotics to disinfect catheter biofilms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis in vitro (Full text)

the efficacy of sublethal dose of UVC light with anti-staphylococcal antibiotics against biofilms made from 30 isolates of methicillin-susceptible Staphylococcus aureus and methicillin-resistant S. aureus and S. epidermidis on vascular catheters.A novel biofilm device was used to assess the combined approach. The biofilms on the catheters were irradiated with the UVC light at 254 nm and irradiance of 6.4 mW followed by treatment with vancomycin or quinupristin/dalfopristin at twice their minimum

2016 Infection and drug resistance PubMed

49. In Vitro Antimicrobial Susceptibility of Staphylococcus pseudintermedius Isolates of Human and Animal Origin (Full text)

In Vitro Antimicrobial Susceptibility of Staphylococcus pseudintermedius Isolates of Human and Animal Origin MIC results for 115 Staphylococcus intermedius group isolates are presented. Of these, 33% were methicillin resistant, among which 51.4% were susceptible to doxycycline, 29.7% to clindamycin, and 21.6% to trimethoprim-sulfamethoxazole. All of the isolates were susceptible to ceftaroline, daptomycin, linezolid, nitrofurantoin, quinupristin-dalfopristin, rifampin, tigecycline

2016 Journal of clinical microbiology PubMed

50. Evaluation of Antimicrobial Resistance in Staphylococcus aureus Isolates by Years (Full text)

) to 21% of all S. aureus isolates between 2009 and 2014. According to the results of susceptibility tests of all isolates of S. aureus, they have been identified as sensitive to vancomycin, daptomycin, linezolid, and levofloxacin. While the resistance rates to nitrofurantoin, quinupristin-dalfopristin, and trimethoprim-sulfamethoxazole were determined as 0.3%, 2.4%, and 6%, respectively, resistance rates to penicillin, erythromycin, rifampicin, gentamicin, and clindamycin were determined as 100%, 18

2016 Interdisciplinary perspectives on infectious diseases PubMed

51. MRSA: treating people with infection (Full text)

evaluation for 12 PICO combinations.In this systematic overview we categorised the efficacy for five interventions, based on information about the effectiveness and safety of cephalosporins (ceftobiprole, ceftaroline), daptomycin, linezolid, quinupristin-dalfopristin, pristinamycin (streptogramins), and tigecycline.

2016 BMJ Clinical Evidence PubMed

52. Antimicrobial Resistance and Molecular Characteristics of Nasal Staphylococcus aureus Isolates From Newly Admitted Inpatients (Full text)

inpatients.In the present study, 66 S. aureus isolates, including 10 healthcare-associated MRSA (HA-MRSA), 8 CA-MRSA, and 48 methicillin-sensitive S. aureus (MSSA) strains, were found in the nasal cavities of 62 patients by screening 292 newlyadmitted patients. Antimicrobial resistance and molecular characteristics of these isolates, including spa-type, sequence type (ST) and SCCmec type, were investigated. All isolates were sensitive to linezolid, teicoplanin, and quinupristin/dalfopristin, but high levels

2016 Annals of laboratory medicine PubMed

53. Characterization of Staphylococcus aureus Biofilm Formation in Urinary Tract Infection (Full text)

used the Modified Congo red agar (MCRA) and Microtiter plate methods to assess the ability of biofilm formation. All isolates were examined for determination of biofilm related genes, icaA, fnbA, clfA and bap using PCR method.Linezolid, quinupristin/dalfopristin and chloramphenicol were the most effective agents against S. aureus isolates. Overall, 69.2% of S. aureus isolates were biofilm producers. Resistance to four antibiotics such as nitrofurantoin (71.4% vs. 28.6%, P=0.001), tetracycline (57.7

2016 Iranian journal of public health PubMed

54. Vancomycin Resistant Enterococcus

disease Cancer ICU care Organ transplant VI. Labs: Culture MIC Susceptible : MIC <4 mcg/ml Vancomycin Resistant Enterococcus: MIC >32 mcg/ml VII. Management: Vancomycin Resistant Enterococcus No single antibiotic is bactericidal Combination therapy is mandatory Susceptible to Antibiotic 1 or /Sulbactam ( ) Antibiotic 2 (increasing resistance) or High resistance to (MIC >64 mg/ml) Quinupristin/dalfopristin ( ) ( ) Combination 1 (three drugs) and and Combination 2 (two drugs) or and Fosfomycin (...) Combination 3 (four drugs) Chloramphenicol and and and Quinupristin/dalfopristin ( ) Antibiotics effective against some strains of VRE (consult infectious disease) Tigecycline (increasing resistance) Imipenem (against E. faecalis only) Telavansin ( s) Quinupristin/dalfopristin or (against E faecium only) Antibiotics effective against UTI with VRE Remove indwelling if possible (may alone, clear VRE) or (UTI) Fosfomycin (UTI) (UTI) Antibiotics for VRE Endocarditis may be needed AND AND VIII. Prevention

2018 FP Notebook

55. Bacterial Meningitis Management

with initially Added in adults and in infection Intraventricular shunt antibiotics may be used if shunt not able to be removed Options: Amikacin, , Polymixin E, Tobramycin, , , Quinupristin-Dalf. V. Management: Antibiotics based on CSF Gram Stain Results Diplococci (Pneumococcus) All cases receive for 4 days Antibiotics for 10-14 days AND OR (or Meropenem or ) AND ( ) or or Pencillin G or or or Chloramphenicol Bacilli ( ) AND Gentamycin OR ( or Meropenem) (H. flu, , Pseudomonas) OR Cefepime (or Meropenem

2018 FP Notebook

56. An Optimized in vitro Antibiotic Susceptibility Testing Method for Small Colony Variant Staphylococcus aureus. (Full text)

isolates (both SCVs and NCs) were susceptible to quinupristin-dalfopristin, vancomycin, minocycline, linezolid, chloramphenicol, and tigecycline. Analysis of SCV auxotrophy type, isogenic NC antibiograms, and antibiotic treatment history had limited utility in predicting SCV susceptibilities. With clinical correlation, this AST method and these results may prove useful in directing treatment for SCV infections. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

2016 Antimicrobial Agents and Chemotherapy PubMed

57. Prevalence of high-level gentamicin-resistant Enterococcus faecalis and Enterococcus faecium in an Iranian hospital (Full text)

(vanA, vanB), resistance to tetracycline (tetK, tetL, tetM, tetO), and resistance to erythromycin (ermA, ermB, ermC) by PCR and multiplex PCR-based methods. Genetic diversity was evaluated via Random Amplified Polymorphic DNA (RAPD)-PCR. All enterococcal isolates showed complete sensitivity to vancomycin with MIC ≤ 0.5μg/ml. Resistance to gentamicin, tetracycline, erythromycin, ciprofloxacin or quinopristin-dalfopristin was detected, whilst more than 96.2% of isolates were high-level

2016 Journal of preventive medicine and hygiene PubMed

58. Drug use and antimicrobial resistance among Escherichia coli and Enterococcus spp. isolates from chicken and turkey flocks slaughtered in Quebec, Canada (Full text)

, and sulfisoxazole was detected in > 90% of flocks for E. coli isolates. Antimicrobial resistance (AMR) was observed to bacitracin, erythromycin, lincomycin, quinupristin-dalfopristin, and tetracycline in both chicken and turkey flocks for Enterococcus spp. isolates. No resistance to vancomycin was observed. The use of ceftiofur at hatchery was significantly associated with the proportion of ceftiofur-resistant E. coli isolates in chicken flocks. In turkey flocks, ceftiofur resistance was more frequent when

2016 Canadian Journal of Veterinary Research PubMed

59. Antimicrobial susceptibility of Staphylococcus pseudintermedius colonizing healthy dogs in Saskatoon, Canada (Full text)

. Staphylococcus pseudintermedius was identified biochemically and antimicrobial minimum inhibitory concentrations were determined by broth microdilution. Methicillin resistance was confirmed by polymerase chain reaction (PCR) and sequencing of the mecA gene. Of 221 S. pseudintermedius isolates from 78 dogs, 7 were methicillin resistant. No resistance to the fluoroquinolones, nitrofurantoin, tigecycline, vancomycin, quinupristin-dalfopristin, linezolid, or daptomycin was identified. Of the 78 positive dogs

2016 The Canadian Veterinary Journal PubMed

60. Evaluation of Genotypic and Phenotypic Methods for Detection of Methicillin Resistant Staphylococcus aureus in a Tertiary Care Hospital of Eastern Odisha (Full text)

lowest sensitivity (82.5%) and specificity (98.5%) among all. The conventional methods take more time than PCR for diagnosing MRSA. Linezolid, Vancomycin & Dalfopristin were the highly sensitive drugs against MRSA isolates.Cefoxitin disc diffusion, is rapid, simple and cheaper, hence can be used routinely as an alternative to PCR for detection of MRSA in resource constraint laboratories.

2016 Journal of clinical and diagnostic research : JCDR PubMed

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