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Quinupristin-Dalfopristin

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41. Antimicrobial Resistance and Molecular Characteristics of Nasal Staphylococcus aureus Isolates From Newly Admitted Inpatients Full Text available with Trip Pro

inpatients.In the present study, 66 S. aureus isolates, including 10 healthcare-associated MRSA (HA-MRSA), 8 CA-MRSA, and 48 methicillin-sensitive S. aureus (MSSA) strains, were found in the nasal cavities of 62 patients by screening 292 newlyadmitted patients. Antimicrobial resistance and molecular characteristics of these isolates, including spa-type, sequence type (ST) and SCCmec type, were investigated. All isolates were sensitive to linezolid, teicoplanin, and quinupristin/dalfopristin, but high levels

2016 Annals of laboratory medicine

42. Vancomycin resistant enterococci in urine cultures: Antibiotic susceptibility trends over a decade at a tertiary hospital in the United Kingdom Full Text available with Trip Pro

near zero to 40%. Ampicillin resistance fluctuated between 50% and 90%. Low resistance was observed for linezolid and quinupristin/dalfopristin. Female sex and inpatient status were identified as risk factors for vancomycin resistance.The incidence of vancomycin resistance among urinary isolates was stable over the last decade. Although resistance to nitrofurantoin has increased, it still serves as an appropriate first choice in uncomplicated urinary tract infection caused by vancomycin-resistant

2016 Investigative and clinical urology

43. In Vitro Antimicrobial Susceptibility of Staphylococcus pseudintermedius Isolates of Human and Animal Origin Full Text available with Trip Pro

In Vitro Antimicrobial Susceptibility of Staphylococcus pseudintermedius Isolates of Human and Animal Origin MIC results for 115 Staphylococcus intermedius group isolates are presented. Of these, 33% were methicillin resistant, among which 51.4% were susceptible to doxycycline, 29.7% to clindamycin, and 21.6% to trimethoprim-sulfamethoxazole. All of the isolates were susceptible to ceftaroline, daptomycin, linezolid, nitrofurantoin, quinupristin-dalfopristin, rifampin, tigecycline

2016 Journal of clinical microbiology

44. Characterization of Staphylococcus aureus Biofilm Formation in Urinary Tract Infection Full Text available with Trip Pro

used the Modified Congo red agar (MCRA) and Microtiter plate methods to assess the ability of biofilm formation. All isolates were examined for determination of biofilm related genes, icaA, fnbA, clfA and bap using PCR method.Linezolid, quinupristin/dalfopristin and chloramphenicol were the most effective agents against S. aureus isolates. Overall, 69.2% of S. aureus isolates were biofilm producers. Resistance to four antibiotics such as nitrofurantoin (71.4% vs. 28.6%, P=0.001), tetracycline (57.7

2016 Iranian journal of public health

45. Efficacy of ultraviolet C light at sublethal dose in combination with antistaphylococcal antibiotics to disinfect catheter biofilms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis in vitro Full Text available with Trip Pro

the efficacy of sublethal dose of UVC light with anti-staphylococcal antibiotics against biofilms made from 30 isolates of methicillin-susceptible Staphylococcus aureus and methicillin-resistant S. aureus and S. epidermidis on vascular catheters.A novel biofilm device was used to assess the combined approach. The biofilms on the catheters were irradiated with the UVC light at 254 nm and irradiance of 6.4 mW followed by treatment with vancomycin or quinupristin/dalfopristin at twice their minimum

2016 Infection and drug resistance

46. When sepsis persists: a review of MRSA bacteraemia salvage therapy. Full Text available with Trip Pro

are the only two antibiotics approved by the US FDA for the treatment of patients with MRSAB as monotherapy, the employment of novel strategies is required to effectively treat patients with persistent MRSAB and these may frequently involve combination drug therapy. Treatment strategies that are reviewed in this manuscript include vancomycin combined with a β-lactam, daptomycin-based therapy, ceftaroline-based therapy, linezolid-based therapy, quinupristin/dalfopristin, telavancin, trimethoprim

2015 Journal of Antimicrobial Chemotherapy

47. Human health risks associated with antimicrobial-resistant enterococci and Staphylococcus aureus on poultry meat. Full Text available with Trip Pro

and transmission of multidrug-resistant E. faecalis lineages such as sequence type ST16. Enterococcus faecium lineages occurring in poultry meat products are distantly related to those causing hospital-acquired infections but may act as donors of quinupristin/dalfopristin resistance and other resistance determinants of clinical interest to the human gut microbiota. Ingestion of poultry meat contaminated with S. aureus may lead to food poisoning. However, antimicrobial resistance in the toxin-producing strains

2015 Clinical Microbiology and Infection

48. Prevalence, species distribution and antimicrobial resistance patterns of methicillin-resistant staphylococci in Lithuanian pet animals Full Text available with Trip Pro

isolates (20.0 %; CI 95 % 13.5-28.6) were obtained from the vagina of female dogs (n = 105) (Group B). All isolates carried the mecA gene. Twelve MRS species were isolated of which S. pseudintermedius was the most common (18/42) followed by S. haemolyticus (8/42) and S. lentus (4/42). MRSA was not found. All MRS strains were susceptible to vancomycin, linezolid, daptomycin and quinupristin/dalfopristin. Resistance to tetracycline (16/21), clindamycin (15/21) and erythromycin (14/21) was the most common

2015 Acta veterinaria Scandinavica

49. Molecular Characterization of Vancomycin Resistant Enterococcus faecium Strains Isolated From Carriage and Clinical Samples in a Tertiary Hospital, Turkey. Full Text available with Trip Pro

by biochemical tests and the API-20 Strep kit. Susceptibility testing was performed using disc-diffusion and broth-dilution methods. PFGE was used for molecular typing of the VREfm strains. The vancomycin resistance and virulence genes were amplified by two-step multiplex PCR. All 55 VREfm isolates were resistant to penicillin G, ampicillin and high-level gentamicin but were susceptible to quinupristin/dalfopristin and linezolid. Multiplex PCR analysis indicated that all isolates harboured vanA and that 41

2015 Journal of Medical Microbiology

52. Dermabacter hominis: a usually daptomycin-resistant gram-positive organism infrequently isolated from human clinical samples Full Text available with Trip Pro

received antimicrobial treatment (ciprofloxacin, ceftriaxone plus vancomycin and amoxicillin/clavulanic acid). At least ten patients had several underlying diseases and conditions, and no direct mortality was observed in relation to the isolated organism. All isolates were susceptible to vancomycin, rifampin and linezolid. Resistance to other antibiotics varied: erythromycin (100%), clindamycin (78.5%), ciprofloxacin (21.4%) and gentamicin, quinupristin-dalfopristin, benzylpenicillin and imipenem 7.1

2014 New Microbes and New Infections

53. Characterization of methicillin-resistant Staphylococcus sciuri isolates from industrially raised pigs, cattle and broiler chickens. Full Text available with Trip Pro

-wild-type (NWT) for gentamicin, penicillin, tiamulin, clindamycin and quinupristin/dalfopristin. The frequency of NWT isolates for fusidic acid and trimethoprim ranged between 78% and 87%. PFGE analysis allowed distinction between two major clusters. Most isolates tested by microarray carried erm and tet genes. Virulence genes were also detected, including an isa gene encoding an immune-evasion factor and the hsdS2 gene encoding a site-specific deoxyribonuclease.This study shows that multiresistant

2014 Journal of Antimicrobial Chemotherapy

54. Mycobacterium Marinum (Diagnosis)

Dermatol . 2005 Apr. 152(4):727-34. . Bråbäck M, Riesbeck K, Forsgren A. Susceptibilities of Mycobacterium marinum to gatifloxacin, gemifloxacin, levofloxacin, linezolid, moxifloxacin, telithromycin, and quinupristin-dalfopristin (Synercid) compared to its susceptibilities to reference macrolides and quinolones. Antimicrob Agents Chemother . 2002 Apr. 46(4):1114-6. . Edelstein H. Mycobacterium marinum skin infections. Report of 31 cases and review of the literature. Arch Intern Med . 1994 Jun 27. 154

2014 eMedicine.com

55. Mycobacterium Marinum (Treatment)

arthritis and osteomyelitis. Br J Rheumatol . 1997 Nov. 36(11):1207-9. . Bartralot R, Garcia-Patos V, Sitjas D, et al. Clinical patterns of cutaneous nontuberculous mycobacterial infections. Br J Dermatol . 2005 Apr. 152(4):727-34. . Bråbäck M, Riesbeck K, Forsgren A. Susceptibilities of Mycobacterium marinum to gatifloxacin, gemifloxacin, levofloxacin, linezolid, moxifloxacin, telithromycin, and quinupristin-dalfopristin (Synercid) compared to its susceptibilities to reference macrolides and quinolones

2014 eMedicine.com

56. Streptococcus Group D Infections (Overview)

with Streptococcus bovis and Streptococcus salivarius: clinical correlates of more accurate identification of isolates. J Clin Microbiol . 1989 Feb. 27(2):305-8. . Mouton JW, Endtz HP, den Hollander JG, et al. In-vitro activity of quinupristin/dalfopristin compared with other widely used antibiotics against strains isolated from patients with endocarditis. J Antimicrob Chemother . 1997 May. 39 Suppl A:75-80. . Baddour LM, Wilson WR, Bayer AS, Fowler VG Jr, Bolger AF, Levison ME, et al. Infective endocarditis

2014 eMedicine.com

57. Staphylococcal Infections (Overview)

of staphylococcal infections (listed alphabetically, not necessarily in order of preference): Cefazolin Ceftaroline Cefuroxime Clindamycin Dalbavancin Daptomycin Dicloxacillin Doxycycline Linezolid Minocycline Nafcillin Oritavancin Quinupristin/dalfopristin Tedizolid Telavancin Tigecycline Trimethoprim-sulfamethoxazole Vancomycin Delafloxacin Surgery Abscesses must be drained and/or debrided. Infections involving a prosthetic joint usually require removal of the prosthesis. Other infections involving

2014 eMedicine.com

58. Enterococcal Infections (Overview)

result in synergistic bactericidal activity against enterococci. The acquisition of vancomycin resistance by enterococci has seriously affected the treatment and infection control of these organisms. VRE, particularly E faecium strains, are frequently resistant to all antibiotics that are effective treatment for vancomycin-susceptible enterococci, which leaves clinicians treating VRE infections with limited therapeutic options. Newer antibiotics (eg, quinupristin-dalfopristin, linezolid, daptomycin (...) , tigecycline) with activity against many VRE strains have improved this situation, but resistance to these agents has already been described. A mutation (G2576U) in the domain V of the 23S rRNA is responsible for linezolid resistance, [ ] whereas resistance to quinupristin-dalfopristin may be the result of several mechanisms: modification of enzymes, active efflux, and target modification. Resistance of E faecalis and E faecium to daptomycin, a newer cyclic lipopeptide antibiotic that acts on the bacterial

2014 eMedicine.com

59. Cellulitis (Treatment)

IV q6-8h Meropenem 1 g IV q8h Ertapenem 1 g IV qd Cefotaxime 2 g IV q6h plus metronidazole 500 mg IV q6h or clindamycin 600-900 mg/kg IV q8h The following are first-line treatments in managing adult S aureus (MSSA) infections [ ] : Nafcillin (for patients with severe penicillin hypersensitivity: vancomycin, linezolid, quinupristin-dalfopristin, or daptomycin; add an appropriate agent in the presence of [or if there is a suspicion of] staphylococcal infection) or oxacillin 1-2 IV q4h Cefazolin 1 g (...) IV q8h Clindamycin 600-900 mg/kg IV q8h (may have cross-resistance and emergence resistance in erythromycin-resistant strains; induces resistance in MRSA) First-line agents in managing severe adult streptococcal infection are penicillin 2-4 MU IV every 4-6 hours plus clindamycin 600-900 mg/kg IV every 8 hours. [ ] For patients with severe penicillin hypersensitivity, use vancomycin, linezolid, quinupristin-dalfopristin, or daptomycin. Add an appropriate agent if a staphylococcal infection

2014 eMedicine.com

60. Cellulitis (Treatment)

IV q6-8h Meropenem 1 g IV q8h Ertapenem 1 g IV qd Cefotaxime 2 g IV q6h plus metronidazole 500 mg IV q6h or clindamycin 600-900 mg/kg IV q8h The following are first-line treatments in managing adult S aureus (MSSA) infections [ ] : Nafcillin (for patients with severe penicillin hypersensitivity: vancomycin, linezolid, quinupristin-dalfopristin, or daptomycin; add an appropriate agent in the presence of [or if there is a suspicion of] staphylococcal infection) or oxacillin 1-2 IV q4h Cefazolin 1 g (...) IV q8h Clindamycin 600-900 mg/kg IV q8h (may have cross-resistance and emergence resistance in erythromycin-resistant strains; induces resistance in MRSA) First-line agents in managing severe adult streptococcal infection are penicillin 2-4 MU IV every 4-6 hours plus clindamycin 600-900 mg/kg IV every 8 hours. [ ] For patients with severe penicillin hypersensitivity, use vancomycin, linezolid, quinupristin-dalfopristin, or daptomycin. Add an appropriate agent if a staphylococcal infection

2014 eMedicine.com

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