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21. Prevalence and molecular characterization of Staphylococcus aureus from human stool samples Full Text available with Trip Pro

study.Out of 625 patients included in the final study, 58 were positive for S. aureus (9.3%). One isolate was positive for the PVL gene. A high number of isolates were resistant to multiple antibiotics including oxacillin (43.1%), erythromycin (51.7%), and levofloxacin (41.4%). All isolates were susceptible to vancomycin, daptomycin, linezolid, and quinupristin-dalfopristin. In the nested study, having a disease or condition of the gastrointestinal tract significantly increased the odds of intestinal

2018 Antimicrobial resistance and infection control

22. Assessment of disinfectant and antibiotic susceptibility patterns and multi-locus variable number tandem repeat analysis of Staphylococcus epidermidis isolated from blood cultures Full Text available with Trip Pro

susceptible to linezolid and quinupristin/dalfopristin, respectively. A total of 55.7% of the isolates were found to be multidrug resistant (MDR). All isolates had MICs of CHG-A and ISP-QAC of 8 folds lower and MIC of QAC-B 6 folds lower than that suggested by the manufacturers. The genes qacA/B and smr were found in 28 (24.3%) and 14 (12.2%) isolates, respectively. MLVA typing of the S. epidermidis isolates resulted in 106 VNTR patterns and 102 MLVA types for the 112 S. epidermidis isolates, considering

2018 Iranian journal of microbiology

23. Molecular characterization of vancomycin-resistant Enterococcus faecium isolates from Bermuda. Full Text available with Trip Pro

isolates were completely analyzed and were all resistant to vancomycin, susceptible to linezolid and quinupristin/dalfopristin, positive for vanA and esp genes. The MLST analysis confirmed most isolates were of the sequence types linked to clonal complex 17 (CC17) that is widely associated with outbreaks in hospitals. Infection control measures, antibiotic stewardship, and surveillance activities will continue to be a priority in hospital on the Island.

2017 PLoS ONE

24. Frequent isolation of methicillin resistant Staphylococcus aureus (MRSA) ST398 among healthy pigs in Portugal. Full Text available with Trip Pro

isolates amplified the mecA gene only and were classified as nontypeable. The majority of the isolates were resistant to tetracycline (100%), clindamycin (97%), erythromycin (96%), chloramphenicol (84%) and gentamycin (69%). Notably, 12% showed resistance to quinupristin-dalfopristin (MICs 3-8 μg/mL). Beta-hemolysin (81%) and gamma-hemolysin (74%) were the unique virulence determinants detected. None of the isolates harboured PVL or mecC gene.This study showed a massive occurrence of ST398-MRSA in two

2017 PLoS ONE

25. Central Venous Access in Oncology

-resistant Linezolidordaptomycin Or Quinupristin/dalfopristin Gram-negative Escherichiacoliand Klebsiellaspp. ESBL-negative: Third-generationcephalosporin(e.g.ceftriaxone) Or Ciprofloxacinoraztreonam ESBL-positive: Carbapenem(e.g.ertapenem,imipenem,meropenemor doripenem) Or Ciprofloxacinoraztreonam Ciprofloxacinoramikacin,bothatthedoseof2g/l, plusheparin20IU/ml Taurolidine2.5ml,eithercombinedwith4%sodium citrate,sodiumheparin2500IUorwith25000IU urokinase Gentamicin5mg/mlplusEDTA30mg/mlfor3days

2015 European Society for Medical Oncology

26. Antimicrobial Resistance and Molecular Characterization of Staphylococcus aureus Causing Childhood Pneumonia in Shanghai Full Text available with Trip Pro

isolates from the respiratory specimens were characterized by antimicrobial susceptibility, agr typing, toxin genes, multilocus sequence typing (MLST), spa, and SCCmec typing. Fifty-eight (54.2%, 58/107) were MSSA (methicillin-susceptible Staphylococcus aureus) and 49 (45.8%, 49/107) were MRSA. No isolates were found resistant to teicoplanin, sulfamethoxazole/trimethoprim, rifampicin, quinupristin/dalfopristin, linezolid, or vancomycin. However, these isolates showed high resistant rates

2017 Frontiers in microbiology

27. Factors associated with Staphylococcus aureus nasal carriage and molecular characteristics among the general population at a Medical College Campus in Guangzhou, South China Full Text available with Trip Pro

) genes. 83.6% of the S. aureus isolates were resistant to penicillin, all isolates were susceptible to quinupristin/dalfopristin, levofloxacin, teicoplanin and vancomycin. The most common risk factors for S. aureus carriage were being male, age ≤30 years, and nasal cavity cleaning habits.Colonization by S. aureus was greater among male and young age (20-30 years) students and those with irregularity nasal cleaning. The S. aureus isolates selected were revealed into various sequence types

2017 Annals of Clinical Microbiology and Antimicrobials

28. Identification of tigecycline- and vancomycin-resistant Staphylococcus aureus strains among patients with urinary tract infection in Iran Full Text available with Trip Pro

to assess the in vitro activity of vancomycin, tigecycline, linezolid and quinupristin/dalfopristin against MRSA isolates from UTI patients. Thirty MRSA strains from 54 S. aureus isolates were isolated from patients with UTI. The antimicrobial susceptibility patterns of the strains were determined by the Kirby-Bauer disk diffusion and broth microdilution methods. PCR assays were used to detect the vanA gene. The MRSA isolates resistant to vancomycin were confirmed using the broth microdilution method (...) . The results revealed that the MRSA isolates were 100% susceptible to linezolid and quinupristin/dalfopristin but 93.3% susceptible to vancomycin and tigecycline respectively. The broth microdilution method confirmed two MRSA strains (6.6%) to be resistant to vancomycin and tigecycline. The study identified vancomycin resistance among the MRSA isolates from UTI patients. This vancomycin resistance in MRSA isolates poses a challenge in managing S. aureus infections. Our study's results highlight the need

2017 New Microbes and New Infections

29. Characterization of Vancomycin Resistant Enterococci in Hospitalized Patients and Role of Gut Colonization Full Text available with Trip Pro

patients and their association with gut colonization.Clinically significant isolates of enterococci (n=250) were studied. Species confirmation was done by Polymerase Chain Reaction (PCR). Minimum Inhibitory Concentration (MIC) for vancomycin was determined by E-test. PCR for VanA, VanB and VanC1 gene was done for genotypic characterization. MIC for teicoplanin, linezolid, tigecycline, daptomycin and quinupristin-dalfopristin was determined by E test. Patients with VRE infection were screened for gut

2017 Journal of clinical and diagnostic research : JCDR

30. Prevalence and Genetic Diversity of Enterococcus faecalis Isolates from Mineral Water and Spring Water in China Full Text available with Trip Pro

isolates were not resistant to 12 kinds of antibiotics (penicillin, ampicillin, linezolid, quinupristin/dalfopristin, vancomycin, gentamicin, streptomycin, ciprofloxacin, levofloxacin, norfloxacin, nitrofurantoin, and tetracycline). Enterobacterial repetitive intergenic consensus-PCR classified 58 isolates and three reference strains into nine clusters with a similarity of 75%. This study is the first to investigate the prevalence of E. faecalis in mineral water and spring water in China. The results

2017 Frontiers in microbiology

31. Role of Combination Antimicrobial Therapy for Vancomycin-Resistant Enterococcus faecium Infections: Review of the Current Evidence. (Abstract)

, and aminoglycosides, further complicates the treatment of these infections. Of particular concern are Enterococcus faecium strains that are associated with the highest rate of vancomycin resistance. The introduction of antimicrobial agents with specific activity against vancomycin-resistant Enterococcus (VRE) faecium including daptomycin, linezolid, quinupristin-dalfopristin, and tigecycline did not completely resolve this clinical dilemma. In this review, the mechanisms of action and resistance to currently

2017 Pharmacotherapy

32. Vancomycin Resistant Enterococcus

disease Cancer ICU care Organ transplant VI. Labs: Culture MIC Susceptible : MIC <4 mcg/ml Vancomycin Resistant Enterococcus: MIC >32 mcg/ml VII. Management: Vancomycin Resistant Enterococcus No single antibiotic is bactericidal Combination therapy is mandatory Susceptible to Antibiotic 1 or /Sulbactam ( ) Antibiotic 2 (increasing resistance) or High resistance to (MIC >64 mg/ml) Quinupristin/dalfopristin ( ) ( ) Combination 1 (three drugs) and and Combination 2 (two drugs) or and Fosfomycin (...) Combination 3 (four drugs) Chloramphenicol and and and Quinupristin/dalfopristin ( ) Antibiotics effective against some strains of VRE (consult infectious disease) Tigecycline (increasing resistance) Imipenem (against E. faecalis only) Telavansin ( s) Quinupristin/dalfopristin or (against E faecium only) Antibiotics effective against UTI with VRE Remove indwelling if possible (may alone, clear VRE) or (UTI) Fosfomycin (UTI) (UTI) Antibiotics for VRE Endocarditis may be needed AND AND VIII. Prevention

2018 FP Notebook

33. Management of Patients with Infections Caused by Methicillin-Resistant Staphylococcus Aureus Full Text available with Trip Pro

and daptomycin are present, options may include the following: quinupristin-dalfopristin 7.5 mg/kg/dose IV every 8 h, TMP-SMX 5 mg/kg/dose IV twice daily, linezolid 600 mg PO/IV twice daily, or telavancin 10 mg/kg/dose IV once daily (C-III) . These options may be given as a single agent or in combination with other antibiotics. XI. What is the management of MRSA infections in neonates? Neonatal pustulosis 74. For mild cases with localized disease, topical treatment with mupirocin may be adequate in full-term (...) inhibitors [ ]. Linezolid causes less bone marrow suppression in children than it causes in adults [ ]. The most common adverse events in children are diarrhea, vomiting, loose stools, and nausea [ ]. The linezolid suspension may not be tolerated because of taste and may not be available in some pharmacies. It is considered pregnancy category C. Quinupristin-Dalfopristin. Quinupristin-dalfopristin is a combination of 2 streptogramin antibiotics and inhibits protein synthesis. It is FDA-approved for cSSTI

2011 Infectious Diseases Society of America

35. An Optimized in vitro Antibiotic Susceptibility Testing Method for Small Colony Variant Staphylococcus aureus. Full Text available with Trip Pro

isolates (both SCVs and NCs) were susceptible to quinupristin-dalfopristin, vancomycin, minocycline, linezolid, chloramphenicol, and tigecycline. Analysis of SCV auxotrophy type, isogenic NC antibiograms, and antibiotic treatment history had limited utility in predicting SCV susceptibilities. With clinical correlation, this AST method and these results may prove useful in directing treatment for SCV infections. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

2016 Antimicrobial Agents and Chemotherapy

36. Evaluation of Antimicrobial Resistance in Staphylococcus aureus Isolates by Years Full Text available with Trip Pro

) to 21% of all S. aureus isolates between 2009 and 2014. According to the results of susceptibility tests of all isolates of S. aureus, they have been identified as sensitive to vancomycin, daptomycin, linezolid, and levofloxacin. While the resistance rates to nitrofurantoin, quinupristin-dalfopristin, and trimethoprim-sulfamethoxazole were determined as 0.3%, 2.4%, and 6%, respectively, resistance rates to penicillin, erythromycin, rifampicin, gentamicin, and clindamycin were determined as 100%, 18

2016 Interdisciplinary perspectives on infectious diseases

37. Antimicrobial susceptibility of Staphylococcus pseudintermedius colonizing healthy dogs in Saskatoon, Canada Full Text available with Trip Pro

. Staphylococcus pseudintermedius was identified biochemically and antimicrobial minimum inhibitory concentrations were determined by broth microdilution. Methicillin resistance was confirmed by polymerase chain reaction (PCR) and sequencing of the mecA gene. Of 221 S. pseudintermedius isolates from 78 dogs, 7 were methicillin resistant. No resistance to the fluoroquinolones, nitrofurantoin, tigecycline, vancomycin, quinupristin-dalfopristin, linezolid, or daptomycin was identified. Of the 78 positive dogs

2016 The Canadian Veterinary Journal

38. Drug use and antimicrobial resistance among Escherichia coli and Enterococcus spp. isolates from chicken and turkey flocks slaughtered in Quebec, Canada Full Text available with Trip Pro

, and sulfisoxazole was detected in > 90% of flocks for E. coli isolates. Antimicrobial resistance (AMR) was observed to bacitracin, erythromycin, lincomycin, quinupristin-dalfopristin, and tetracycline in both chicken and turkey flocks for Enterococcus spp. isolates. No resistance to vancomycin was observed. The use of ceftiofur at hatchery was significantly associated with the proportion of ceftiofur-resistant E. coli isolates in chicken flocks. In turkey flocks, ceftiofur resistance was more frequent when

2016 Canadian Journal of Veterinary Research

39. Newer antibiotics for the treatment of peritoneal dialysis-related peritonitis Full Text available with Trip Pro

/dalfopristin. Teicoplanin is not available in some countries (e.g. the USA). Tigecycline can only be given intravenously. Quinupristin/dalfopristin is ineffective against Enterococcus faecalis and there is only low-quality evidence to support its efficacy in the treatment of peritonitis. Effective newer antibiotics against drug-resistant Gram-negative bacteria are lacking. Polymyxins can be considered, but evidence on its efficacy is limited. In this review, we will discuss the potential use of newer (...) be used due to allergy and/or non-susceptibility, there is increasing evidence that linezolid and daptomycin are the drugs of choice. It is reasonable to start linezolid orally or intravenously, but subsequent dose reduction may be necessary in case of myelosuppression. Daptomycin can be given intravenously or intraperitoneally and has excellent anti-biofilm activity. Other treatment options for drug-resistant Gram-positive bacterial peritonitis include teicoplanin, tigecycline and quinupristin

2016 Clinical kidney journal

40. MRSA: treating people with infection Full Text available with Trip Pro

evaluation for 12 PICO combinations.In this systematic overview we categorised the efficacy for five interventions, based on information about the effectiveness and safety of cephalosporins (ceftobiprole, ceftaroline), daptomycin, linezolid, quinupristin-dalfopristin, pristinamycin (streptogramins), and tigecycline.

2016 BMJ Clinical Evidence

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