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Quinupristin-Dalfopristin

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1. The use of high-throughput sequencing to investigate an outbreak of glycopeptide-resistant Enterococcus faecium with a novel quinupristin-dalfopristin resistance mechanism (PubMed)

The use of high-throughput sequencing to investigate an outbreak of glycopeptide-resistant Enterococcus faecium with a novel quinupristin-dalfopristin resistance mechanism High-throughput sequencing (HTS) has successfully identified novel resistance genes in enterococci and determined clonal relatedness in outbreak analysis. We report the use of HTS to investigate two concurrent outbreaks of glycopeptide-resistant Enterococcus faecium (GRE) with an uncharacterised resistance mechanism (...) to quinupristin-dalfopristin (QD). Seven QD-resistant and five QD-susceptible GRE isolates from a two-centre outbreak were studied. HTS was performed to identify genes or predicted proteins that were associated with the QD-resistant phenotype. MLST and SNP typing on HTS data was used to determine clonal relatedness. Comparative genomic analysis confirmed this GRE outbreak involved two distinct clones (ST80 and ST192). HTS confirmed the absence of known QD resistance genes, suggesting a novel mechanism

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2018 European Journal of Clinical Microbiology & Infectious Diseases

2. Daptomycin-Vancomycin–Resistant Enterococcus faecium Native Valve Endocarditis: Successfully Treated With Off-Label Quinupristin-Dalfopristin (PubMed)

Daptomycin-Vancomycin–Resistant Enterococcus faecium Native Valve Endocarditis: Successfully Treated With Off-Label Quinupristin-Dalfopristin Multidrug-resistant enterococcal nosocomial invasive infections are a rising concern faced by the medical community. Not many options are available to treat these highly virulent organisms. Risk factors for developing these highly resistant organisms include prolonged hospital stay, previous antibiotic use, and immunosuppression. In this article, we (...) report a case of daptomycin-resistant enterococcal native infective endocarditis treated with off-label use of quinupristin-dalfopristin.

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2016 Journal of investigative medicine high impact case reports

3. Characteristic of Enterococcus faecium clinical isolates with quinupristin/dalfopristin resistance in China (PubMed)

Characteristic of Enterococcus faecium clinical isolates with quinupristin/dalfopristin resistance in China Quinupristin/dalfopristin (Q/D) is a valuable alternative antibiotic to vancomycin for the treatment of multi-drug resistant Enterococcus faecium infections. However, resistance to Q/D in E. faecium clinical isolates and nosocomial dissemination of Q/D-resistant E. faecium have been reported in several countries and should be of concern.From January 2012 to December 2015, 911 E. faecium

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2016 BMC microbiology

4. Safety of intravitreal quinupristin/dalfopristin in an animal model (PubMed)

Safety of intravitreal quinupristin/dalfopristin in an animal model To determine whether different intravitreal doses of quinupristin/dalfopristin lead to electroretinographic or histological changes in the rabbit retina over one month period after injection.Eighteen New Zealand white rabbits were divided into three treatment groups (groups 1 to 3) and different intravitreal doses of quinupristin/dalfopristin were tested in each group. The right eye was injected with the drug and the left eye (...) (Kruskall-Wallis test, P=0.000). By day 7, no electrical response to light stimuli was recorded in the treated eyes in groups 2 and 3, consistent with severe damage due to retinal toxicity. Light microscopy revealed no significant histopathological changes in the group 1, while rabbits in groups 2 and 3 had signs of granulomatous inflammation in most cases.Intravitreal 0.1 mg/0.1 mL doses of quinupristin/dalfopristin do not lead to electroretinographic or histological signs of retinal toxicity compared

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2016 International journal of ophthalmology

5. Quinupristin-Dalfopristin

Quinupristin-Dalfopristin Quinupristin-Dalfopristin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Quinupristin-Dalfopristin (...) Quinupristin-Dalfopristin Aka: Quinupristin-Dalfopristin , Synercid , Streptogramin From Related Chapters II. Indications: Severe Gram Positive Infections -resistant susceptible susceptible III. Mechanism l 50S Ribosome Resistance rare IV. Pharmacokinetics Hepatic clearance predominates Half-life: 1-3 hours (9-10 hours of affect) V. Adverse Effects s or myalgias , or Rash or VI. Drug Interactions: Metabolized by Cytochrome P-450 3A4 Raises serum drug levels of substrates in 3A4 system Follow levels when

2018 FP Notebook

6. Quinupristin-Dalfopristin

Quinupristin-Dalfopristin Quinupristin-Dalfopristin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Quinupristin-Dalfopristin (...) Quinupristin-Dalfopristin Aka: Quinupristin-Dalfopristin , Synercid , Streptogramin From Related Chapters II. Indications: Severe Gram Positive Infections -resistant susceptible susceptible III. Mechanism l 50S Ribosome Resistance rare IV. Pharmacokinetics Hepatic clearance predominates Half-life: 1-3 hours (9-10 hours of affect) V. Adverse Effects s or myalgias , or Rash or VI. Drug Interactions: Metabolized by Cytochrome P-450 3A4 Raises serum drug levels of substrates in 3A4 system Follow levels when

2015 FP Notebook

7. Quinupristin and Dalfopristin

Quinupristin and Dalfopristin Quinupristin and Dalfopristin - Infectious Diseases - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / OTHER TOPICS IN THIS CHAPTER Test your knowledge Smallpox Because (...) Loading , PharmD, University of Washington School of Pharmacy Click here for Patient Education NOTE: This is the Professional Version. CONSUMERS: Quinupristin and dalfopristin are streptogramin , which, like and , inhibit the synthesis of bacterial proteins. Quinupristin/dalfopristin (Q/D) is given together in a fixed 30/70 combination; this combination has synergistic bactericidal activity against the following: and , including strains resistant to other antibiotic classes Some gram-negative sp

2013 Merck Manual (19th Edition)

8. Activity of quinupristin/dalfopristin against extracellular and intracellular Staphylococcus aureus with various resistance phenotypes. (PubMed)

Activity of quinupristin/dalfopristin against extracellular and intracellular Staphylococcus aureus with various resistance phenotypes. Treatment of chronic or recurrent Staphylococcus aureus infections may require using antibiotics with activity against intracellular multiresistant organisms. Quinupristin/dalfopristin (3:7) has been examined in this context.Quinupristin and dalfopristin were used separately or mixed. Strains used were: (i) methicillin-susceptible and -resistant S. aureus (MSSA (...) and MRSA); (ii) one vat(B) MSSA and msr(A/B) MRSA; (iii) erm(A)+ [MSSA, MRSA, vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA)]; and (iv) one erm(A/B)+ cfr+ MRSA resistant to quinupristin, dalfopristin and their combination. Assessment of activity was determined by: (i) MICs (CLSI method); and (ii) concentration-response curves in broth and after phagocytosis by THP-1 macrophages, with descriptors of the model (Emin) and the pharmacodynamic response [maximal relative

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2010 Journal of Antimicrobial Chemotherapy

18. Relatively high rates of cefotaxime- and ceftriaxone-non-susceptible isolates among group B streptococci with reduced penicillin susceptibility (PRGBS) in Japan. (PubMed)

, as recommended by the CLSI.The rates of non-susceptibility/resistance to ampicillin, cefotaxime, ceftriaxone and levofloxacin for the 80 PSGBS isolates were 0%, 0%, 0% and 30%, respectively, but were 15% (P = 0.0003), 28% (P < 0.0001), 36% (P < 0.0001) and 93% (P < 0.0001) for the 74 PRGBS isolates, respectively. No PRGBS isolates were identified to be non-susceptible to meropenem, doripenem, vancomycin, quinupristin/dalfopristin, daptomycin or linezolid.We found that cefotaxime- and ceftriaxone-non

2019 Journal of Antimicrobial Chemotherapy

19. Antimicrobial resistance monitoring in commensal enterococci from healthy cattle, pigs and chickens across Europe during 2004-14 (EASSA Study). (PubMed)

was non-WT (NWT), with a daptomycin MIC of 8 mg/L. Clinical vancomycin resistance was very low or absent; eight strains had decreased susceptibility (MICs of 8 mg/L). Two strains were clinically resistant to tigecycline. Little resistance to ampicillin or gentamicin was observed. Clinical resistance of E. faecium to quinupristin/dalfopristin was slightly higher (2.2%-33.6%) and 38.5%-83.2% of the strains were classified NWT. Very high resistance to tetracycline (67.4%-79.1%) and erythromycin (27.1

2019 Journal of Antimicrobial Chemotherapy

20. High incidence of virulence determinants, aminoglycoside and vancomycin resistance in enterococci isolated from hospitalized patients in Northwest Iran. (PubMed)

was identified as predominant enterococci (69%), followed by "other" Enterococcus species (21%) and E. faecium (10%). Ninety three percent of isolates were resistant to one or more antimicrobial agents, with the most frequent resistance found against tetracycline (86%), ciprofloxacin (73%) and quinupristin-dalfopristin (53%). Gentamicin and streptomycin resistance were detected in 50 and 34% of isolates, respectively. The most prevalent aminoglycoside resistance genes were ant (3″)-III (78%) and aph (3

2019 BMC Infectious Diseases

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