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Quad Screen

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1. Quad Screen

Quad Screen Quad Screen Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Quad Screen Quad Screen Aka: Quad Screen , Aneuploidy (...) Screening , Triple Analyte Screen , Triple Screen , Antepartum Neural Tube Defect Screening , Antepartum Down Syndrome Screening , Second Trimester Quad Maternal Screen Panel II. Indication Congenital defect screening in low risk pregnancy III. Components: Tests comprising Quad Screen (AFP) Increased with s Decreased in and Trisomy 18 Human chorionic gonadotropin (Free bHCG) Increased in and decreased in Trisomy 18 (uE3) Decreased in and Trisomy 18 Inhibin A Increased in and normal in Trisomy 18 IV

2018 FP Notebook

2. Screening of fetal aneuploidies whereby non-invasive prenatal test (NIPT)

Screening of fetal aneuploidies whereby non-invasive prenatal test (NIPT) Dec2015 © EUnetHTA, 2015. Reproduction is authorised provided EUnetHTA is explicitly acknowledged 1 EUnetHTA Joint Action 3 WP4 Version 1.5, 23 rd February 2018 Rapid assessment of other technologies using the HTA Core Model ® for Rapid Relative Effectiveness Assessment SCREENING OF FETAL TRISOMIES 21, 18 AND 13 BY NONINVASIVE PRENATAL TESTING Project ID: OTCA03 Screening of fetal trisomies 21, 18 and 13 by noninvasive (...) Cunqueiro Hospital, Spain, who had undergone NIPT participated in the draft project plan consultation phase. Screening of fetal trisomies 21, 18 and 13 by noninvasive prenatal testing Version 1.5, 23rd February 2018 EUnetHTA Joint Action 3 WP4 3 Consultation of the draft rapid assessment Manufacturers [v 1.2] (factual accuracy check) Sequenom Laboratories, San Diego, CA, USA Ariosa Diagnostics Inc./Roche Sequencing Solutions Inc., San Jose, California, USA Natera ® , San Carlos, CA, USA Premaitha Health

2018 EUnetHTA

3. Quad Screen

Quad Screen Quad Screen Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Quad Screen Quad Screen Aka: Quad Screen , Aneuploidy (...) Screening , Triple Analyte Screen , Triple Screen , Antepartum Neural Tube Defect Screening , Antepartum Down Syndrome Screening , Second Trimester Quad Maternal Screen Panel II. Indication Congenital defect screening in low risk pregnancy III. Components: Tests comprising Quad Screen (AFP) Increased with s Decreased in and Trisomy 18 Human chorionic gonadotropin (Free bHCG) Increased in and decreased in Trisomy 18 (uE3) Decreased in and Trisomy 18 Inhibin A Increased in and normal in Trisomy 18 IV

2015 FP Notebook

4. Prenatal Screening for Down Syndrome, Trisomy 18, and Open Neural Tube Defect

Prenatal Screening for Down Syndrome, Trisomy 18, and Open Neural Tube Defect Perinatal Services BC Obstetric Guideline: Prenatal Screening for Down Syndrome, Trisomy 18 and Open Neural Tube Defects Table of Contents EXECUTIVE SUMMARY ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 2 1? INTRODUCTION ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 3 SIPS, IPS, Quad, NIPT ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 3 Open Neural Tube Defects (ONTDs (...) screen result from IPS, SIPS, or Quad; b) Women who have a documented history of a previous child or fetus with Down syndrome, trisomy 18, or trisomy 13; c) Women whose risk of Down syndrome is equal to or greater than 1/300 based on the finding of ultrasound marker(s) and results of SIPS / IPS / Quad? 1 In order to ensure quality NT ultrasounds, every certified sonographer must annually perform a minimum number of ultrasounds? As such, pregnant women 30 years and older in Northern Health Authority

2014 British Columbia Perinatal Health Program

5. Clinical Evaluation of the IONA Test for Non-invasive Pre Natal Screening in Twin Pregnancies

information Ages Eligible for Study: 16 Years and older (Child, Adult, Older Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Currently pregnant with twin foetuses at time of entry to study Have had or are about to have a conventional screening test (combined/quad test, ultrasound scan or other NIPT) If identified as high risk, intend to undergo prenatal invasive diagnosis and/or undergoing invasive prenatal therapy such as laser treatment for TTTS where (...) Clinical Evaluation of the IONA Test for Non-invasive Pre Natal Screening in Twin Pregnancies Clinical Evaluation of the IONA Test for Non-invasive Pre Natal Screening in Twin Pregnancies - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2016 Clinical Trials

6. First trimester screening for Down syndrome using nuchal translucency, maternal serum pregnancy-associated plasma protein A, free-β human chorionic gonadotrophin, placental growth factor and α-fetoprotein. (PubMed)

(first trimester quad) was assessed.For affected pregnancies, the median PlGF level was 0.622 MoM and median AFP 0.764 MoM. Adding PlGF and AFP improved the screening performance. At 3% FPR, DR increased by 4.4% from 83.8% to 88.2% using enhanced FTS; at 95% DR, FPR decreased by 8.3%, from 19.3% to 11.0%. At 3% FPR, DR using first trimester quad test was 76.4%.The performance of FTS can be enhanced by adding PlGF and AFP. Even without nuchal translucency, the test would perform well.© 2015 John Wiley (...) First trimester screening for Down syndrome using nuchal translucency, maternal serum pregnancy-associated plasma protein A, free-β human chorionic gonadotrophin, placental growth factor and α-fetoprotein. The aim of this study was to assess the screening performance for Down syndrome using first trimester combined screening (FTS) and two additional markers, serum placental growth factor (PlGF) and α-fetoprotein (AFP).This is a retrospective case-control study of 137 pregnancies affected

2015 Prenatal diagnosis

7. Will a quadruple multiplexed point-of-care screening strategy for HIV-related co-infections be feasible and impact detection of new co-infections in at-risk populations? Results from cross-sectional studies. (PubMed)

Will a quadruple multiplexed point-of-care screening strategy for HIV-related co-infections be feasible and impact detection of new co-infections in at-risk populations? Results from cross-sectional studies. Multiplexed point-of-care (POC) devices can rapidly screen for HIV-related co-infections (eg, hepatitis C (HCV), hepatitis B (HBV), syphilis) in one patient visit, but global evidence for this approach remains limited. This study aimed to evaluate a multiplex POC testing strategy (...) to expedite screening for HIV-related co-infections in at-risk populations.A multiplex strategy was developed with two subsequent versions of an investigational device Miriad. It was evaluated in two non-comparable settings and populations in two countries for feasibility of conduct, detection of new infections, preference and accuracy. Version 1 was evaluated in 375 sexually transmitted disease clinic attendees in Mumbai, India; version 2 was evaluated in 119 injection drug users in Montreal

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2014 BMJ open

8. AFP Maternal Screening

AFP Maternal Screening Second trimester maternal screening Produced by In partnership with User Top Links Menu Search User Top Links Search Second trimester maternal screening Also Known As Triple test Quad/quadruple test Formal Name Maternal Serum Screen This article was last reviewed on 19 February 2014. This article was last modified on 26 October 2018. At a Glance Why Get Tested? To assess the risk of a foetus having certain chromosomal abnormalities, such as or Edward’s syndrome (trisomy (...) 18). When To Get Tested? In most centres women will be offered between 11-13 weeks, although for some it may be carried out in the second trimester, usually between 14 and 20 weeks of . Sample Required? A blood sample taken from a vein in the arm. The results from the laboratory may be combined with the results from an ultrasound scan to improve the overall effectiveness of the screening test. Test Preparation Needed? None Looking for Test Results? On average it takes 7 working days for the blood

2012 Lab Tests Online UK

9. Study of the Efficacy of New Non-invasive Prenatal Tests for Screening for Fetal Trisomies Using Maternal Blood

Other: Serum QUAD Assay for aneuploidy screening Other: Semiconductor MPSS NIPT assay using ccfDNA in maternal blood Other: Optical-based MPSS NIPT assay using ccfDNA in maternal blood Other: Harmony™ Test (Ariosa Diagnostics) Not Applicable Detailed Description: The present study is a real life comparative effectiveness study that will compare the performances and costs of several prenatal screening modalities for fetal aneuploidy (see interventions). Study Design Go to Layout table for study (...) : related topics: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Low Risk of aneuploidy Integrated prenatal screening for Down's syndrome (with follow-up fetal karyotype if positive); Serum QUAD Assay for aneuploidy screening; Semiconductor MPSS NIPT assay using ccfDNA in maternal blood; Optical-based MPSS NIPT assay using ccfDNA in maternal blood; Harmony™ Test (Ariosa Diagnostics) Other: Integrated prenatal screening for Down's syndrome Analysis of several serum

2013 Clinical Trials

10. First-trimester Down syndrome screening using additional serum markers with and without nuchal translucency and cell-free DNA. (PubMed)

First-trimester Down syndrome screening using additional serum markers with and without nuchal translucency and cell-free DNA. This study aimed to evaluate serum-only four-marker first trimester (1T-Quad) Down syndrome screening, alone or contingently to select 10-20% with highest risk for nuchal translucency (NT) or cell-free (cf)DNA.Stored maternal serum samples (-80 °C) from 90 pregnancies with fetal Down syndrome and 1607 controls were retrieved and measured for placental growth factor, α (...) -fetoprotein, pregnancy-associated plasma protein and free β-human chorionic gonadotropin. Samples were from singleton pregnancies (9-13 + 6 weeks), and NT was measured between 11 and 13 + 6 weeks. Markers were expressed in multiples of the normal median (MoM) for gestation. Gaussian models were fitted to the distribution of log MoMs by using observed parameters, standardized maternal age distribution (mean 27, SD 5.5) and published cfDNA results.The model-predicted detection rate (DR) for 1T-Quad was 74

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2013 Prenatal diagnosis

11. Use of ethnic-specific medians for Hispanic patients reduces ethnic disparities in multiple marker screening. (PubMed)

Use of ethnic-specific medians for Hispanic patients reduces ethnic disparities in multiple marker screening. To estimate whether midtrimester maternal serum analyte concentrations differ between Caucasian and Hispanic women and whether using ethnic-specific medians affects quad screen performance.Caucasian and Hispanic patients with singletons who underwent maternal serum screening in our laboratory were identified. Alfa-fetoprotein (AFP), estriol, human chorionic gonadotrophin (hCG (...) was higher (P < 0.0001). Using composite medians, the screen-positive rate (SPR) for trisomy 21 was 5.39% in Caucasians and 3.29% in Hispanics. Ethnic-specific medians reduced this disparity: 4.76% in Caucasians and 4.05% in Hispanics. The SPR for neural tube defects with composite medians was 1.44% for Caucasians and 0.89% for Hispanics; with ethnic-specific medians, the SPR was 1.42% for Caucasians and 1.07% for Hispanics.Serum analyte concentrations differ between Caucasian and Hispanic gravidas. Use

2011 Prenatal diagnosis

12. Prenatal Care

for certain high-risk populations (see Table 5). • Screening for aneuploidy and neural tube defects should be offered to all pregnant women. - Women at average risk of aneuploidy should be offered the integrated screen or prenatal risk quad screen (see Table 6). - Women at high risk of aneuploidy can be offered screening with cell-free DNA, plus separate neural tube defect screening with AFP (see Table 7 and Figure 1). Carrier status screening Table 5. First trimester screening for inherited disorders (...) at AVERAGE RISK of aneuploidy Both the integrated screen and the prenatal risk quad screen (PRS), which is often referred to as the “quadscreen, are reasonable options for estimating patient-specific risk for chromosome abnormalities (see Table 6). The integrated screen has a higher detection rate (96% vs. 81%) than the PRS (Malone 2005), but other factors such as timing, maternal preference, and availability may favor the PRS screen. Whichever screening test is used, the patient should be advised

2018 Kaiser Permanente Clinical Guidelines

13. Effect of early, brief computerized interventions on risky alcohol and cannabis use among young people

computerized brief intervention used as a stand-alone treatment aimed at reducing alcohol and/or cannabis consumption. Eligible comparators included no intervention, waiting list control or an alternative brief intervention (computerized or non-computerized). Participants were young people between 15 and 25 years of age who were defined as risky consumers of alcohol or cannabis, or both. DATA COLLECTION AND ANALYSIS Two researchers independently screened titles and abstracts against the inclusion criteria (...) drinks for men in the past 30 days). Exclusion criteria: None reported Interventions Intervention (Number randomised): n = 242 Description: Personalize normative feedback based on the normative feedback component of BASICS (Brief Alcohol Screening and Intervention for College Students). Duration: baseline questionnaire took appr. 30 minutes. Delivery (e.g., via app, computer): web page Comparison (Number randomised): n = 231 Description: No-treatment control Duration: baseline questionnaire took appr

2017 Campbell Collaboration

14. All-Terrain Vehicle Injuries, Prevention of

, 2017 was conducted in July of 2017. In addition to the electronic search, manual review of bibliographies of articles and recent reviews was by the lead author (D.K.J.). Study Selection FIGURE 1. PRISMA flow diagram. PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Two independent researchers (R.R., D.K.J.) screened titles and abstracts using the aforementioned inclusion and exclusion criteria. Any disagreement was adjudicated by a third, senior, GRADE-trained researcher (...) Association Trauma Committee position statement on the use of all-terrain vehicles by children and youth. J Pediatr Surg . 2009;44(8):1638–1639. Yanchar NL. Preventing injuries from all-terrain vehicles. Paediatr Child Health . 2012;17(9):513–514. American College of Emergency Physicians (ACEP). Motorized recreational vehicle and watercraft safety. Policy statement. Ann Emerg Med . 2013;61(6):725–726. Franklin RC, Knight S, Lower T. Mount Isa statement on quad bike safety. Rural Remote Health . 2014;14(3

2018 Eastern Association for the Surgery of Trauma

15. Management of Pregnancy

. Implementation 18 IV. Guideline Work Group 19 V. Algorithm 20 A. Algorithm Key 21 B. Actions at Every Visit 21 C. Interventions by Weeks Gestation 21 D. Standard of Pregnancy Care 23 a. Additional Information on Actions at Every Visit 23 b. Screenings 24 c. Time Sensitive Care 28 d. Summary 28 VA/DoD Clinical Practice Guideline for the Management of Pregnancy March 2018 Page 4 of 147 VI. Routine Pregnancy Care 29 VII. Recommendations 33 A. Care Throughout Pregnancy 36 a. Routine Care During Pregnancy 36 b (...) . Nutrition 39 c. Screening 40 d. Education 43 B. One-time Interventions 44 a. Screening and Diagnostic Testing 44 b. Imaging 49 c. Preparing for Delivery 50 d. Postpartum Care 51 C. Referral 52 D. Special Considerations 55 a. High Risk for Preeclampsia 55 b. High Risk for Preterm Delivery 56 c. Over 44 Years of Age 57 d. History of Bariatric Surgery 58 Appendix A: Evidence Review Methodology 62 A. Developing the Scope and Key Questions 62 a. Population(s) 62 b. Interventions 62 c. Comparators 64 d

2018 VA/DoD Clinical Practice Guidelines

16. Early Prenatal Care Summary Checklist for Primary Care Providers

women. • Off er appropriate test(s) based on woman’s age, when she accesses care, local resources, and her choice. Note options are time-sensitive. Available Tests for Prenatal Genetic Screening • SIPS – Serum Integrated Prenatal Screen: Part I at 9 -13 +6 wks; Part 2 at 14-20 +6 wks. • IPS – Integrated Prenatal Screen: SIPS + NT ultrasound at 11-13 +6 wks. • Quad Screen – SIPS Part 2 • NIPT – Noninvasive Prenatal Screen / cell-free fetal DNA: single serum test from 10 wks on. • FTS – First (...) Trimester Screening: serum test and US for NT, nasal bones, fetal heart rate, Ductus Venosus fl ow at 11-14 wks. Publicly Funded Testing vs. Private Pay • SIPS or Quad screen is covered by BC Medical Services Plan (MSP) for all women. • IPS is covered by MSP for women 35 and older, twins, other high risk criteria, and regional exceptions. • NIPT is covered by MSP for higher risk of trisomy based on history or initial screening (see PSBC website, NIPT). • NT can be accessed from private providers

2016 British Columbia Perinatal Health Program

17. Management of Pregnancies Diagnosed with Down Syndrome

at discharge?Perinatal Services BC Management of Pregnancies Diagnosed with Down Syndrome 5 INTRODUCTION Prenatal screening by Serum Integrated Prenatal Screen (SIPS)/Integrated Prenatal Screen (IPS)/Quad, Non Invasive Prenatal Testing (NIPT) and ultrasound allows for the identification of most pregnancies with Down syndrome? Counselling of these pregnant women and their partner should provide accurate, current and balanced information that presents the obstetrical risks (increased risk of prematurity (...) ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 13 WORKING GROUP WHO DEVELOPED THIS PRACTICE RESOURCE ? ? ? ? ? ? ? ? ? ? 14Perinatal Services BC Management of Pregnancies Diagnosed with Down Syndrome 3 SUMMARY Prenatal screening and ultrasound allows for most pregnancies with Down syndrome to be identified prenatally ? Care of the family who have received a diagnosis of Down syndrome should be provided by an interdisciplinary team including clinical geneticists and genetic counsellors, pediatricians, obstetricians, the family’s primary care

2016 British Columbia Perinatal Health Program

18. HTA of smoking cessation interventions

on individual smokers. The time horizon over which the costs and benefits of screening was calculated was 20 years and both costs and benefits were discounted at 5%. ? A budget impact analysis reporting the incremental costs associated with changes to the provision of smoking cessation services over a five-year time horizon was performed from the perspective of the public health system only. ? An analysis of the ethical, legal and organisational implications of changes to the provision of smoking cessation

2017 Health Information and Quality Authority

19. Ancillary benefits of prenatal maternal serum screening achieved in the California program. (PubMed)

Ancillary benefits of prenatal maternal serum screening achieved in the California program. To evaluate the extent of fetal structural abnormalities, other than neural tube and abdominal wall defects (AWDs), identified by California's Prenatal Screening Program.The Quad Marker Prenatal Screening records of 516,172 women were examined for screening interpretation and the diagnosis of structural abnormalities detected via follow-up. Women who were screen-positive for trisomy 21, trisomy 18 (...) , neural tube defects (NTDs) or Smith-Lemli-Opitz syndrome (SLOS) received follow-up services at state-approved Prenatal Diagnosis Centers (PDCs). Detailed reports of services and diagnostic information were linked in a database to the original screening results.A total of 26 323 women received follow-up ultrasound services at the PDCs in the study time period. Of these women, 1085 (4.1%) were identified as having fetuses with significant structural abnormalities, other than NTDs (n = 207) or AWDs (n

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2010 Prenatal diagnosis

20. CRACKCast E049 – General Principles to Orthopedic Injuries

to transient paralysis and return to function in weeks – months Axonotmesis – crush injury to a nerve – slow nerve healing Neurotmesis – severing of a nerve that requires surgical repair See table 49-4 Light touch is a good screening test, but two-point discrimination is more sensitive (especially for digital nerves). Compare the sensation bilaterally. Consider the O’Riain wrinkle test or the Ninhydrin sweat test for digital nerve injuries. Compartment Syndrome Any # or damage in an osseofascial space (...) anesthesia e) Acetabular fracture i) Sciatic nerve Motor: plantar flexion, knee flexion, lower leg muscles. Spares the hamstrings Sensory: peroneal, tibial, sural f) Hip fracture i) Femoral nerve Motor: quads weakness Sensation: anterior or medial thigh g) Femoral shaft fracture i) Sciatic Motor: leg weakness of the lower leg Same as sciatic. h) Knee dislocation i) Tibial or peroneal Peroneal Weak dorsiflexion and eversion dorsum of foot, first webspace, lateral foot. Tibial: Motor: foot muscle atrophy

2016 CandiEM

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