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Q Fever

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161. Q Fever in the United States: Summary of Case Reports from Two National Surveillance Systems, 2000-2012. (PubMed)

Q Fever in the United States: Summary of Case Reports from Two National Surveillance Systems, 2000-2012. Q fever is a worldwide zoonosis historically associated with exposure to infected livestock. This study summarizes cases of Q fever, a notifiable disease in the United States, reported to the Centers for Disease Control and Prevention through two national surveillance systems with onset during 2000-2012. The overall incidence rate during this time was 0.38 cases per million persons per year (...) . The reported case fatality rate was 2.0%, and the reported hospitalization rate was 62%. Most cases (61%) did not report exposure to cattle, goats, or sheep, suggesting that clinicians should consider Q fever even in the absence of livestock exposure. The prevalence of drinking raw milk among reported cases of Q fever (8.4%) was more than twice the national prevalence for the practice. Passive surveillance systems for Q fever are likely impacted by underreporting and underdiagnosis because

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2014 American Journal of Tropical Medicine & Hygiene

162. Reevaluation of the Risk of Fetal Death and Malformation after Q Fever. (PubMed)

Reevaluation of the Risk of Fetal Death and Malformation after Q Fever. A meta-analysis of 136 Q fever pregnancies, including 4 new cases and 7 population-based serological studies, revealed significant increases in fetal death and malformation after Q fever during pregnancy. This poor obstetric outcome is prevented by antibiotic treatment. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions

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2014 Clinical Infectious Diseases

163. Q fever in the Netherlands: public perceptions and behavioral responses in three different epidemiological regions: a follow-up study. (PubMed)

Q fever in the Netherlands: public perceptions and behavioral responses in three different epidemiological regions: a follow-up study. Over the past years, Q fever has become a major public health problem in the Netherlands, with a peak of 2,357 human cases in 2009. In the first instance, Q fever was mainly a local problem of one province with a high density of large dairy goat farms, but in 2009 an alarming increase of Q fever cases was observed in adjacent provinces. The aim of this study (...) was to identify trends over time and regional differences in public perceptions and behaviors, as well as predictors of preventive behavior regarding Q fever.One cross-sectional survey (2009) and two follow-up surveys (2010, 2012) were performed. Adults, aged≥18 years, that participated in a representative internet panel were invited (survey 1, n=1347; survey 2, n=1249; survey 3, n=1030).Overall, public perceptions and behaviors regarding Q fever were consistent with the trends over time in the numbers of new

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2014 BMC Public Health

164. Screening of post-mortem tissue donors for Coxiella burnetii infection after large outbreaks of Q fever in The Netherlands. (PubMed)

Screening of post-mortem tissue donors for Coxiella burnetii infection after large outbreaks of Q fever in The Netherlands. After the largest outbreaks of Q fever ever recorded in history occurred in the Netherlands, concern arose that Coxiella may be transmitted via donated tissues of latent or chronically infected donors. The Dutch Health Council recently advised to screen tissue donors, donating high risk tissues, for Coxiella infection.After validation of an enzyme immunoassay (EIA) test (...) of the tests for use on post-mortem samples, 50/1033 donors (4.8%) screened positive for phase 2 anti-Coxiella IgG by EIA, and 31 were confirmed by IFA (3.0%). One donor showed a serological profile compatible with chronic infection. All tested tissues (25 corneas, 6 heart valves, 4 skin and 3 bone marrow) from donors with IgG reactivity tested negative for the presence of Coxiella DNA. Except for living in a postal code area with a high number of Q fever notifications, no risk factors for IgG reactivity

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2014 BMC Infectious Diseases

165. Fulminant hepatic failure and acute renal failure as manifestations of concurrent Q fever and cytomegalovirus infection: a case report. (PubMed)

Fulminant hepatic failure and acute renal failure as manifestations of concurrent Q fever and cytomegalovirus infection: a case report. Coxiella burnetii is an obligate bacterial pathogen that causes Q fever. Cytomegalovirus (CMV) commonly exists as a latent infection in healthy people. Co-infection with both pathogens is rare.We report an immunocompetent 53-year-old male farmer who presented with fulminant hepatic failure and acute renal failure. Empiric antibiotic treatment with intravenous (...) penicillin G and levofloxacin were given, but hepatic and renal functions continued to deteriorate. A subsequent test of serum immunoglobulin M was positive for CMV, and administration of gancyclovir led to gradual recovery. A diagnosis of acute Q fever was confirmed by indirect immunofluorescence assay (IFA) on paired serum samples to demonstrate a significant rise in antibody titers. Antibiotic treatment was adjusted accordingly.CMV co-infection should be considered in patients with acute Q fever when

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2014 BMC Infectious Diseases

166. Q-fever patients suffer from impaired health status long after the acute phase of the illness: Results from a 24-month cohort study. (PubMed)

Q-fever patients suffer from impaired health status long after the acute phase of the illness: Results from a 24-month cohort study. During the largest Q-fever outbreak ever reported, a cohort study was established to assess the health status of Q-fever patients over a 24-month period and to identify factors associated with health status.Laboratory-confirmed Q-fever patients participated at six time points after onset of illness. Scores on twelve subdomains from two health status instruments (...) were calculated for each time point to determine progression and compare to reference groups.The study included 336 Q-fever patients. There is a significant linear improvement over time in nine of the twelve health status subdomains. For example, the proportion of patients with severe fatigue improved from 73.0% at three months to 60.0% at twelve months and 37.0% at twenty-four months, but this was still high compared to a healthy reference group (2.5%). For the three most severely affected

2014 Journal of Infection

168. Efficacy of liposome-encapsulated ciprofloxacin in a murine model of Q fever. (PubMed)

Efficacy of liposome-encapsulated ciprofloxacin in a murine model of Q fever. Encapsulation of antibiotics may improve treatment of intracellular infections by prolonging antibiotic release and improving antibiotic uptake into cells. In this study, liposome-encapsulated ciprofloxacin for inhalation (CFI) was evaluated as a postexposure therapeutic for the treatment of Coxiella burnetii, the causative agent of Q fever. Intranasal treatment of male A/Jola (A/J) mice with CFI (50 mg/kg of body (...) and reduced bacterial numbers in the lungs and spleen compared to mice treated with oral ciprofloxacin or doxycycline. When a single dose of CFI was administered, it provided better protection against body weight loss than 7 days of treatment with oral doxycycline, the current antibiotic of choice to treat Q fever. These data suggest that CFI has potential as a superior antibiotic to treat Q fever. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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2014 Antimicrobial Agents and Chemotherapy

169. Safety and Immunogenicity of Q Fever Vaccine

Safety and Immunogenicity of Q Fever Vaccine Safety and Immunogenicity of Q Fever Vaccine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety and Immunogenicity of Q Fever Vaccine The safety (...) by (Responsible Party): U.S. Army Medical Research and Materiel Command Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the safety of Q Fever Vaccine, Phase I, Inactivated, Dried, NDBR 105 and collect data on incidence of occupational Q fever infection in vaccinated personnel. Condition or disease Intervention/treatment Phase Q Fever Biological: Q fever Vaccine Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical

2014 Clinical Trials

170. Q fever epidemic in Hungary, April to July 2013. (PubMed)

Q fever epidemic in Hungary, April to July 2013. We investigated a Q fever outbreak with human patients showing high fever, respiratory tract symptoms, headache and retrosternal pain in southern Hungary in the spring and summer of 2013. Seventy human cases were confirmed by analysing their serum and blood samples with micro-immunofluorescence test and real-time PCR. The source of infection was a merino sheep flock of 450 ewes, in which 44.6% (25/56) seropositivity was detected by enzyme-linked

2014 Euro Surveillance

171. Estimating the transfusion transmission risk of Q fever. (PubMed)

Estimating the transfusion transmission risk of Q fever. The Q fever outbreaks in the Netherlands in 2007 to 2009 initiated discussion on the necessity of measures to prevent transmission through blood products. Risk assessments help transfusion regulators decide when and where measures are required. This study assesses the transfusion transmission (TT) risk of Q fever using the European Up-Front Risk Assessment Tool (EUFRAT) model.We estimated the number of Q fever infections in recipients (...) recipients infected with Q fever, respectively. Between June 1, 2009, and January 31, 2010, the probability of a donor being infected with Q fever in the high-incidence areas was estimated at 260 (95% confidence interval, 192-340) per 100,000 donors, consistent with results from the donation testing study. The EUFRAT estimates were also consistent with estimates from the Biggerstaff model. Scenario analyses showed that donation testing provided the largest risk reduction of various risk reduction

2014 Transfusion

172. Screening of blood donors for chronic Coxiella burnetii infection after large Q fever outbreaks. (PubMed)

Screening of blood donors for chronic Coxiella burnetii infection after large Q fever outbreaks. The Netherlands experienced major Q fever outbreaks from 2007 through 2009. An increasing number of human chronic Q fever cases has been reported in the affected area. Blood donors unaware of chronic Coxiella burnetii infection might be infectious for transfusion recipients. Local blood donations were screened for serologic signs of chronic Coxiella infection.From August 2012 through January 2013 (...) , a total of 2490 serum samples were collected from all consenting blood donors in the most affected Q fever outbreak area and screened for Phase II anti-Coxiella immunoglobulin G antibodies using an enzyme-linked immunosorbent assay (ELISA). (Phase II antibodies are considered indicative for resolved or ongoing Coxiella infection.) Reactive samples were confirmed by quantitative immunofluorescent Phase I and II antibody testing. A Phase I antibody titer of at least 1024 was considered indicative

2014 Transfusion

173. Genome Sequence of Coxiella burnetii Strain AuQ01 (Arandale) from an Australian Patient with Acute Q Fever (PubMed)

Genome Sequence of Coxiella burnetii Strain AuQ01 (Arandale) from an Australian Patient with Acute Q Fever Coxiella burnetii strain AuQ01 was isolated from the serum of an Australian acute Q fever patient and represents the first whole genome from this historical Q fever country. This new genome shows distinct differences from existing genomic data and will enhance the understanding of this query pathogen. Copyright © 2014 Walter et al.

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2014 Genome Announcements

174. Draft genome sequence of Coxiella burnetii Dog Utad, a strain isolated from a dog-related outbreak of Q fever (PubMed)

Draft genome sequence of Coxiella burnetii Dog Utad, a strain isolated from a dog-related outbreak of Q fever Coxiella burnetii Dog Utad, with a 2 008 938 bp genome is a strain isolated from a parturient dog responsible for a human familial outbreak of acute Q fever in Nova Scotia, Canada. Its genotype, determined by multispacer typing, is 21; the only one found in Canada that includes Q212, which causes endocarditis. Only 107 single nucleotide polymorphisms and 16 INDELs differed from Q212

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2014 New Microbes and New Infections

175. Q Fever Endocarditis and New Coxiella burnetii Genotype, Saudi Arabia (PubMed)

Q Fever Endocarditis and New Coxiella burnetii Genotype, Saudi Arabia 24655815 2014 12 16 2018 11 13 1080-6059 20 4 2014 Apr Emerging infectious diseases Emerging Infect. Dis. Q fever endocarditis and new Coxiella burnetii genotype, Saudi Arabia. 726-8 10.3201/eid2004.131603 Angelakis Emmanouil E Johani Sameer S Ahsan Azeem A Memish Ziad Z Raoult Didier D eng Case Reports Letter United States Emerg Infect Dis 9508155 1080-6040 IM Adolescent Coxiella burnetii genetics Endocarditis, Bacterial (...) epidemiology microbiology Genotype Humans Male Middle Aged Q Fever epidemiology microbiology Saudi Arabia epidemiology Coxiella burnetii Q fever Saudi Arabia bacteria genotype multispacer sequence typing zoonoses 2014 3 25 6 0 2014 3 25 6 0 2014 12 17 6 0 ppublish 24655815 10.3201/eid2004.131603 PMC3966385 Am J Trop Med Hyg. 1966 Sep;15(5):784-98 5950521 Am Heart J. 1983 Jan;105(1):151-3 6849229 CMAJ. 1985 Dec 15;133(12):1228-30 4063935 Rev Sci Tech. 1992 Dec;11(4):1163-8 1305861 Clin Infect Dis. 2013 Sep

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2014 Emerging Infectious Diseases

176. Q fever outbreak in the terraced vineyards of Lavaux, Switzerland (PubMed)

Q fever outbreak in the terraced vineyards of Lavaux, Switzerland Coxiella burnetii infection (Q fever) is a widespread zoonosis with low endemicity in Switzerland, therefore no mandatory public report was required. A cluster of initially ten human cases of acute Q fever infections characterized by prolonged fever, asthenia and mild hepatitis occurred in 2012 in the terraced vineyard of Lavaux. Epidemiological investigations based on patients' interviews and veterinary investigations included (...) outbreak. Since November 2012, mandatory reporting of Q fever to Swiss public health authorities has been reintroduced. A close follow up of human cases will be necessary to identify chronic Q fever.

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2014 New Microbes and New Infections

177. Seroepidemiological Survey of Q Fever and Brucellosis in Kurdistan Province, Western Iran (PubMed)

Seroepidemiological Survey of Q Fever and Brucellosis in Kurdistan Province, Western Iran Given that the there is little information about the current status of brucellosis and Q fever in most parts of Iran, the aim of this study was to assay the seroprevalence of these two diseases in high-risk populations of Kurdistan Province in western Iran. Two hundred fifty sera samples were collected from hunters and their families, butchers, health care workers, and those referred to medical diagnostic (...) laboratories in the southwestern regions of Kurdistan Province. Sera were tested to detect specific immunoglobulin G (IgG) antibodies against brucellosis and Coxiella burnetii (phase I and II). The seroprevalence of brucellosis and Q fever (C. burnetii IgG phase I and II) was 6.4% and 27.83% (20% and 14.52%), respectively. The highest seroprevalence of Q fever (38%) and brucellosis (12%) was seen in butchers, who handled cattle, sheep, and goats during their work. Age had a significant positive association

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2014 Vector Borne and Zoonotic Diseases

178. Chronic Q fever: An ongoing challenge in diagnosis and management (PubMed)

Chronic Q fever: An ongoing challenge in diagnosis and management Chronic Q fever is a potentially fatal disease. The current difficulty in the diagnosis of this condition is discussed in the present article. A 51-year-old woman with a history of aortic valve replacement presented with complaints of feeling generally unwell, pyrexia and occasional unproductive cough over a period of several weeks. Phase 1 immunoglobulin G titre to Coxiella burnetii was initially detected at a low level (1:320 (...) , detected using immunofluorescence) and was not considered to be significant according to the modified Duke criteria. Later in the course of her illness, the patient's antibody titre rose to a high level (1:1280). The issues regarding current laboratory diagnosis and management of Q fever are discussed. Chronic Q fever can be associated with an inadequate serological response. Close follow-up of cases is essential. The recommended serological criteria for the diagnosis of Q fever endocarditis needs

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2014 The Canadian Journal of Infectious Diseases & Medical Microbiology

179. Q Fever (Overview)

Q Fever (Overview) Q Fever: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjI3MTU2LW92ZXJ2aWV3 processing > Q Fever Updated: Oct 11, 2017 Author: Kerry O Cleveland (...) , MD; Chief Editor: Burke A Cunha, MD Share Email Print Feedback Close Sections Sections Q Fever Overview Practice Essentials Q fever (see the image below) is a zoonosis caused by Coxiella burnetii, an obligate gram-negative intracellular bacterium. Cattle, sheep, and goats are the primary reservoirs although a variety of species may be infected. Transmission to humans occurs primarily through inhalation of aerosols from contaminated soil or animal waste. Other rare modes of transmission include

2014 eMedicine Pediatrics

180. Q Fever (Follow-up)

Q Fever (Follow-up) Q Fever Treatment & Management: Approach Considerations, Management of Acute Q Fever, Management of Chronic Q Fever Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjI3MTU2LXRyZWF0bWVudA (...) == processing > Q Fever Treatment & Management Updated: Oct 11, 2017 Author: Kerry O Cleveland, MD; Chief Editor: Burke A Cunha, MD Share Email Print Feedback Close Sections Sections Q Fever Treatment Approach Considerations As with any patient with a febrile illness, the physician should maintain a sufficient level of suspicion about any patient with fever to exclude other potentially life-threatening diseases, which, in the case of tick-borne disease, involves presumptive antibiotic therapy. Although

2014 eMedicine Pediatrics

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