How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

3,613 results for

Q Fever

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

161. Ado-trastuzumab emtansine (T-DM1) in patients with HER2 amplified tumors excluding breast and gastric/gastro-esophageal junction (GEJ) adenocarcinomas: Results from the NCI-MATCH Trial (EAY131) Sub-protocol Q. Full Text available with Trip Pro

Ado-trastuzumab emtansine (T-DM1) in patients with HER2 amplified tumors excluding breast and gastric/gastro-esophageal junction (GEJ) adenocarcinomas: Results from the NCI-MATCH Trial (EAY131) Sub-protocol Q. The NCI-MATCH is a national precision medicine study incorporating centralized genomic testing to direct refractory cancer patients to molecularly targeted treatment subprotocols. This treatment subprotocol was designed to screen for potential signals of efficacy of ado-trastuzumab (...) gland and 1 parotid gland squamous cell cancer. Seventeen patients (47%) had stable disease (SD) including 8/10 (80%) with ovarian and uterine carcinomas, with median duration of 4.6 months. The 6-month progression free survival rate was 23.6% (90% CI 14.2%-39.2%). Common toxicities included fatigue, anemia, fever and thrombocytopenia with no new safety signals. There was a trend for tumor shrinkage with higher levels of gene copy number as determined by the NGS assay.T-DM1 was well tolerated. While

2019 Annals of Oncology

162. Seroepidemiological Survey of Q Fever and Brucellosis in Kurdistan Province, Western Iran Full Text available with Trip Pro

Seroepidemiological Survey of Q Fever and Brucellosis in Kurdistan Province, Western Iran Given that the there is little information about the current status of brucellosis and Q fever in most parts of Iran, the aim of this study was to assay the seroprevalence of these two diseases in high-risk populations of Kurdistan Province in western Iran. Two hundred fifty sera samples were collected from hunters and their families, butchers, health care workers, and those referred to medical diagnostic (...) laboratories in the southwestern regions of Kurdistan Province. Sera were tested to detect specific immunoglobulin G (IgG) antibodies against brucellosis and Coxiella burnetii (phase I and II). The seroprevalence of brucellosis and Q fever (C. burnetii IgG phase I and II) was 6.4% and 27.83% (20% and 14.52%), respectively. The highest seroprevalence of Q fever (38%) and brucellosis (12%) was seen in butchers, who handled cattle, sheep, and goats during their work. Age had a significant positive association

2014 Vector Borne and Zoonotic Diseases

163. Chronic Q fever: An ongoing challenge in diagnosis and management Full Text available with Trip Pro

Chronic Q fever: An ongoing challenge in diagnosis and management Chronic Q fever is a potentially fatal disease. The current difficulty in the diagnosis of this condition is discussed in the present article. A 51-year-old woman with a history of aortic valve replacement presented with complaints of feeling generally unwell, pyrexia and occasional unproductive cough over a period of several weeks. Phase 1 immunoglobulin G titre to Coxiella burnetii was initially detected at a low level (1:320 (...) , detected using immunofluorescence) and was not considered to be significant according to the modified Duke criteria. Later in the course of her illness, the patient's antibody titre rose to a high level (1:1280). The issues regarding current laboratory diagnosis and management of Q fever are discussed. Chronic Q fever can be associated with an inadequate serological response. Close follow-up of cases is essential. The recommended serological criteria for the diagnosis of Q fever endocarditis needs

2014 The Canadian Journal of Infectious Diseases & Medical Microbiology

164. Q fever outbreak in the terraced vineyards of Lavaux, Switzerland Full Text available with Trip Pro

Q fever outbreak in the terraced vineyards of Lavaux, Switzerland Coxiella burnetii infection (Q fever) is a widespread zoonosis with low endemicity in Switzerland, therefore no mandatory public report was required. A cluster of initially ten human cases of acute Q fever infections characterized by prolonged fever, asthenia and mild hepatitis occurred in 2012 in the terraced vineyard of Lavaux. Epidemiological investigations based on patients' interviews and veterinary investigations included (...) outbreak. Since November 2012, mandatory reporting of Q fever to Swiss public health authorities has been reintroduced. A close follow up of human cases will be necessary to identify chronic Q fever.

2014 New Microbes and New Infections

165. Genome Sequence of Coxiella burnetii Strain AuQ01 (Arandale) from an Australian Patient with Acute Q Fever Full Text available with Trip Pro

Genome Sequence of Coxiella burnetii Strain AuQ01 (Arandale) from an Australian Patient with Acute Q Fever Coxiella burnetii strain AuQ01 was isolated from the serum of an Australian acute Q fever patient and represents the first whole genome from this historical Q fever country. This new genome shows distinct differences from existing genomic data and will enhance the understanding of this query pathogen. Copyright © 2014 Walter et al.

2014 Genome Announcements

166. Q Fever Endocarditis and New Coxiella burnetii Genotype, Saudi Arabia Full Text available with Trip Pro

Q Fever Endocarditis and New Coxiella burnetii Genotype, Saudi Arabia 24655815 2014 12 16 2018 11 13 1080-6059 20 4 2014 Apr Emerging infectious diseases Emerging Infect. Dis. Q fever endocarditis and new Coxiella burnetii genotype, Saudi Arabia. 726-8 10.3201/eid2004.131603 Angelakis Emmanouil E Johani Sameer S Ahsan Azeem A Memish Ziad Z Raoult Didier D eng Case Reports Letter United States Emerg Infect Dis 9508155 1080-6040 IM Adolescent Coxiella burnetii genetics Endocarditis, Bacterial (...) epidemiology microbiology Genotype Humans Male Middle Aged Q Fever epidemiology microbiology Saudi Arabia epidemiology Coxiella burnetii Q fever Saudi Arabia bacteria genotype multispacer sequence typing zoonoses 2014 3 25 6 0 2014 3 25 6 0 2014 12 17 6 0 ppublish 24655815 10.3201/eid2004.131603 PMC3966385 Am J Trop Med Hyg. 1966 Sep;15(5):784-98 5950521 Am Heart J. 1983 Jan;105(1):151-3 6849229 CMAJ. 1985 Dec 15;133(12):1228-30 4063935 Rev Sci Tech. 1992 Dec;11(4):1163-8 1305861 Clin Infect Dis. 2013 Sep

2014 Emerging Infectious Diseases

167. Histological characteristics of the abdominal aortic wall in patients with vascular chronic Q fever Full Text available with Trip Pro

Histological characteristics of the abdominal aortic wall in patients with vascular chronic Q fever The aim of this study was to describe specific histological findings of the Coxiella burnetii-infected aneurysmal abdominal aortic wall. Tissue samples of the aneurysmal abdominal aortic wall from seven patients with chronic Q fever and 15 patients without evidence of Q fever infection were analysed and compared. Chronic Q fever was diagnosed using serology and tissue PCR analysis. Histological (...) sections were stained using haematoxylin and eosin staining, Elastica van Gieson staining and immunohistochemical staining for macrophages (CD68), T lymphocytes (CD3), T lymphocyte subsets (CD4 and CD8) and B lymphocytes (CD20). Samples were scored by one pathologist, blinded for Q fever status, using a standard score form. Seven tissue samples from patients with chronic Q fever and 15 tissue samples from patients without Q fever were collected. Four of seven chronic Q fever samples showed

2014 International journal of experimental pathology

168. Efficacy of liposome-encapsulated ciprofloxacin in a murine model of Q fever. Full Text available with Trip Pro

Efficacy of liposome-encapsulated ciprofloxacin in a murine model of Q fever. Encapsulation of antibiotics may improve treatment of intracellular infections by prolonging antibiotic release and improving antibiotic uptake into cells. In this study, liposome-encapsulated ciprofloxacin for inhalation (CFI) was evaluated as a postexposure therapeutic for the treatment of Coxiella burnetii, the causative agent of Q fever. Intranasal treatment of male A/Jola (A/J) mice with CFI (50 mg/kg of body (...) and reduced bacterial numbers in the lungs and spleen compared to mice treated with oral ciprofloxacin or doxycycline. When a single dose of CFI was administered, it provided better protection against body weight loss than 7 days of treatment with oral doxycycline, the current antibiotic of choice to treat Q fever. These data suggest that CFI has potential as a superior antibiotic to treat Q fever. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

2014 Antimicrobial Agents and Chemotherapy

169. Q Fever in French Guiana. Full Text available with Trip Pro

Q Fever in French Guiana. Coxiella burnetii, the causative agent of Q fever, is present worldwide. Recent studies have shown that this bacterium is an emerging pathogen in French Guiana and has a high prevalence (24% of community-acquired pneumonia). In this review, we focus on the peculiar epidemiology of Q fever in French Guiana. We place it in the context of the epidemiology of the disease in the surrounding countries of South America. We also review the clinical features of Q fever (...) in this region, which has severe initial presentation but low mortality rates. These characteristics seem to be linked to a unique genotype (genotype 17). Finally, we discuss the issue of the animal reservoir of C. burnetii in French Guiana, which is still unknown. Further studies are necessary to identify this reservoir. Identification of this reservoir will improve the understanding of the Q fever epidemic in French Guiana and will provide new tools to control this public health problem. © The American

2014 American Journal of Tropical Medicine & Hygiene

170. Safety and Immunogenicity of Q Fever Vaccine

Safety and Immunogenicity of Q Fever Vaccine Safety and Immunogenicity of Q Fever Vaccine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety and Immunogenicity of Q Fever Vaccine The safety (...) by (Responsible Party): U.S. Army Medical Research and Materiel Command Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the safety of Q Fever Vaccine, Phase I, Inactivated, Dried, NDBR 105 and collect data on incidence of occupational Q fever infection in vaccinated personnel. Condition or disease Intervention/treatment Phase Q Fever Biological: Q fever Vaccine Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical

2014 Clinical Trials

171. Q fever in the Netherlands: public perceptions and behavioral responses in three different epidemiological regions: a follow-up study. Full Text available with Trip Pro

Q fever in the Netherlands: public perceptions and behavioral responses in three different epidemiological regions: a follow-up study. Over the past years, Q fever has become a major public health problem in the Netherlands, with a peak of 2,357 human cases in 2009. In the first instance, Q fever was mainly a local problem of one province with a high density of large dairy goat farms, but in 2009 an alarming increase of Q fever cases was observed in adjacent provinces. The aim of this study (...) was to identify trends over time and regional differences in public perceptions and behaviors, as well as predictors of preventive behavior regarding Q fever.One cross-sectional survey (2009) and two follow-up surveys (2010, 2012) were performed. Adults, aged≥18 years, that participated in a representative internet panel were invited (survey 1, n=1347; survey 2, n=1249; survey 3, n=1030).Overall, public perceptions and behaviors regarding Q fever were consistent with the trends over time in the numbers of new

2014 BMC Public Health

172. Serious long-term health consequences of Q-fever and Legionnaires' disease. Full Text available with Trip Pro

Serious long-term health consequences of Q-fever and Legionnaires' disease. We assessed and compared the long-term health status of Q-fever patients and patients with Legionnaires' disease.Q-fever patients and patients with Legionnaires' disease fulfilling the Dutch notification criteria filled out a questionnaire at one year after onset of illness. The proportion of patients with an abnormal score was calculated for 12 health status subdomains and mean scores for the most relevant subdomains (...) were compared between the patient groups.We included 309 Q-fever patients and 190 patients with Legionnaires' disease in the study. A large proportion of the two patient groups was negatively affected on many of the subdomains, especially 'Fatigue', 'General Quality of Life' and 'Role Physical'. We assessed health status of the patient groups using a multivariate regression analysis and found no significant difference for 'Fatigue' and 'General Quality of Life'. Only for the subdomain 'Role

2014 Journal of Infection

173. Persistent high antibody titres against Coxiella burnetii after acute Q fever not explained by continued exposure to the source of infection: a case¿control study. Full Text available with Trip Pro

Persistent high antibody titres against Coxiella burnetii after acute Q fever not explained by continued exposure to the source of infection: a case¿control study. From 2007 to 2010, (the southern part of) the Netherlands experienced a large Q fever epidemic, with more than 4,000 reported symptomatic cases. Approximately 1 - 5% of the acute Q fever patients develop chronic Q fever. A high IgG antibody titre against phase I of Coxiella burnetii during follow-up is considered a marker of chronic (...) Q fever. However, there is uncertainty about the significance and cause of persistence of high IgG phase I antibody titres in patients that do not have any additional manifestations of chronic Q fever. We studied whether continued or repeated exposure to the source of infection could explain elevated IgG phase I antibody levels.A case-control study was performed to analyze predictors for possible chronic Q fever. Possible chronic Q fever cases (n = 53) are patients with phase I IgG antibody

2014 BMC Infectious Diseases

174. Q-fever patients suffer from impaired health status long after the acute phase of the illness: Results from a 24-month cohort study. Full Text available with Trip Pro

Q-fever patients suffer from impaired health status long after the acute phase of the illness: Results from a 24-month cohort study. During the largest Q-fever outbreak ever reported, a cohort study was established to assess the health status of Q-fever patients over a 24-month period and to identify factors associated with health status.Laboratory-confirmed Q-fever patients participated at six time points after onset of illness. Scores on twelve subdomains from two health status instruments (...) were calculated for each time point to determine progression and compare to reference groups.The study included 336 Q-fever patients. There is a significant linear improvement over time in nine of the twelve health status subdomains. For example, the proportion of patients with severe fatigue improved from 73.0% at three months to 60.0% at twelve months and 37.0% at twenty-four months, but this was still high compared to a healthy reference group (2.5%). For the three most severely affected

2014 Journal of Infection

175. Fulminant hepatic failure and acute renal failure as manifestations of concurrent Q fever and cytomegalovirus infection: a case report. Full Text available with Trip Pro

Fulminant hepatic failure and acute renal failure as manifestations of concurrent Q fever and cytomegalovirus infection: a case report. Coxiella burnetii is an obligate bacterial pathogen that causes Q fever. Cytomegalovirus (CMV) commonly exists as a latent infection in healthy people. Co-infection with both pathogens is rare.We report an immunocompetent 53-year-old male farmer who presented with fulminant hepatic failure and acute renal failure. Empiric antibiotic treatment with intravenous (...) penicillin G and levofloxacin were given, but hepatic and renal functions continued to deteriorate. A subsequent test of serum immunoglobulin M was positive for CMV, and administration of gancyclovir led to gradual recovery. A diagnosis of acute Q fever was confirmed by indirect immunofluorescence assay (IFA) on paired serum samples to demonstrate a significant rise in antibody titers. Antibiotic treatment was adjusted accordingly.CMV co-infection should be considered in patients with acute Q fever when

2014 BMC Infectious Diseases

176. Q Fever Reporting: Tip of the Iceberg? Full Text available with Trip Pro

Q Fever Reporting: Tip of the Iceberg? 25404072 2015 04 20 2018 12 02 1476-1645 92 2 2015 Feb The American journal of tropical medicine and hygiene Am. J. Trop. Med. Hyg. Q Fever reporting: tip of the iceberg? 217-8 10.4269/ajtmh.14-0636 Hartzell Joshua D JD Infectious Diseases Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland joshua.d.hartzell.mil@mail.mil. eng Editorial Comment 2014 11 17 United States Am J Trop Med Hyg 0370507 0002-9637 AIM IM (...) Am J Trop Med Hyg. 2015 Feb;92(2):247-55 25404080 Am J Trop Med Hyg. 2015 Feb;92(2):244-6 25404074 Animals Female Humans Male Q Fever epidemiology 2014 11 19 6 0 2014 11 19 6 0 2015 4 22 6 0 ppublish 25404072 ajtmh.14-0636 10.4269/ajtmh.14-0636 PMC4347312 Am J Trop Med Hyg. 2015 Feb;92(2):247-55 25404080 Am J Trop Med Hyg. 2015 Feb;92(2):244-6 25404074 Vector Borne Zoonotic Dis. 2002 Fall;2(3):179-91 12737547 Clin Microbiol Infect. 2006 May;12 Suppl 3:12-24 16669925 Am J Trop Med Hyg. 2009 Oct;81

2014 American Journal of Tropical Medicine & Hygiene

177. Q Fever in the United States: Summary of Case Reports from Two National Surveillance Systems, 2000-2012. Full Text available with Trip Pro

Q Fever in the United States: Summary of Case Reports from Two National Surveillance Systems, 2000-2012. Q fever is a worldwide zoonosis historically associated with exposure to infected livestock. This study summarizes cases of Q fever, a notifiable disease in the United States, reported to the Centers for Disease Control and Prevention through two national surveillance systems with onset during 2000-2012. The overall incidence rate during this time was 0.38 cases per million persons per year (...) . The reported case fatality rate was 2.0%, and the reported hospitalization rate was 62%. Most cases (61%) did not report exposure to cattle, goats, or sheep, suggesting that clinicians should consider Q fever even in the absence of livestock exposure. The prevalence of drinking raw milk among reported cases of Q fever (8.4%) was more than twice the national prevalence for the practice. Passive surveillance systems for Q fever are likely impacted by underreporting and underdiagnosis because

2014 American Journal of Tropical Medicine & Hygiene

178. Persistent Q fever and ischaemic stroke in elderly patients. Full Text available with Trip Pro

Persistent Q fever and ischaemic stroke in elderly patients. Whether persistent or chronic Q fever may act as a risk factor for stroke is unknown. A case-control study was conducted in the Hospital Universitario de Burgos (Spain) between February 2011 and December 2012. A total of 803 samples from 634 consecutive hospitalized patients ≥65 years old were tested, of whom 111 were cases (patients with prevalent or incident ischaemic stroke and/or transient ischaemic attack) and 523 were controls (...) (patients without ischaemic stroke and/or transient ischaemic attack). Immunoglobulin G (IgG) antibody titres phase I and II against Q fever, and IgG antibodies levels against Chlamydia pneumoniae and cytomegalovirus (CMV), were determined using immunofluorescence assay and ELISA methods, respectively. Phase I IgG titres against Coxiella burnetii ≥1:256 (compatible with chronic or persistent Q fever) were detected in 16 of 110 (14.5%) cases and in 32 of 524 (6.1%) controls; P = .004, odds ratio (OR) 2.6

2014 Clinical Microbiology and Infection

179. Screening of post-mortem tissue donors for Coxiella burnetii infection after large outbreaks of Q fever in The Netherlands. Full Text available with Trip Pro

Screening of post-mortem tissue donors for Coxiella burnetii infection after large outbreaks of Q fever in The Netherlands. After the largest outbreaks of Q fever ever recorded in history occurred in the Netherlands, concern arose that Coxiella may be transmitted via donated tissues of latent or chronically infected donors. The Dutch Health Council recently advised to screen tissue donors, donating high risk tissues, for Coxiella infection.After validation of an enzyme immunoassay (EIA) test (...) of the tests for use on post-mortem samples, 50/1033 donors (4.8%) screened positive for phase 2 anti-Coxiella IgG by EIA, and 31 were confirmed by IFA (3.0%). One donor showed a serological profile compatible with chronic infection. All tested tissues (25 corneas, 6 heart valves, 4 skin and 3 bone marrow) from donors with IgG reactivity tested negative for the presence of Coxiella DNA. Except for living in a postal code area with a high number of Q fever notifications, no risk factors for IgG reactivity

2014 BMC Infectious Diseases

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>