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Q Fever

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141. Genetic variation in pattern recognition receptors and adaptor proteins associated with development of chronic Q fever. Full Text available with Trip Pro

Genetic variation in pattern recognition receptors and adaptor proteins associated with development of chronic Q fever. Q fever is an infection caused by Coxiella burnetii. Persistent infection (chronic Q fever) develops in 1%-5% of patients. We hypothesize that inefficient recognition of C. burnetii and/or activation of host-defense in individuals carrying genetic variants in pattern recognition receptors or adaptors would result in an increased likelihood to develop chronic Q fever.Twenty (...) -four single-nucleotide polymorphisms in genes encoding Toll-like receptors, nucleotide-binding oligomerization domain-like receptor-2, αvβ3 integrin, CR3, and adaptors myeloid differentiation primary response protein 88 (MyD88), and Toll interleukin 1 receptor domain-containing adaptor protein (TIRAP) were genotyped in 139 patients with chronic Q fever and in 220 controls with cardiovascular risk-factors and previous exposure to C. burnetii. Associations between these single-nucleotide

2015 Journal of Infectious Diseases

142. Population Screening for Chronic Q-Fever Seven Years after a Major Outbreak Full Text available with Trip Pro

Population Screening for Chronic Q-Fever Seven Years after a Major Outbreak From 2007 through 2010, the Netherlands experienced a large Q-fever epidemic, with 4,107 notifications. The most serious complication of Q-fever is chronic Q-fever.In 2014, we contacted all 2,161 adult inhabitants of the first village in the Netherlands affected by the Q-fever epidemic and offered to test for antibodies against Coxiella burnetii using immunofluorescence assay (IFA) to screen for chronic infections (...) and assess whether large-scale population screening elsewhere is warranted.Of the 1,517 participants, 33.8% were IFA-positive. Six IFA-positive participants had an IgG phase I titer ≥1:512. Two of these six participants were previously diagnosed with chronic Q-fever. Chronic infection was diagnosed in one of the other four participants after clinical examination.Seven years after the initial outbreak, seroprevalence remains high, but the yield of screening the general population for chronic Q-fever

2015 PloS one

143. Improved correlation of human Q fever incidence to modelled C. burnetii concentrations by means of an atmospheric dispersion model Full Text available with Trip Pro

Improved correlation of human Q fever incidence to modelled C. burnetii concentrations by means of an atmospheric dispersion model Atmospheric dispersion models (ADMs) may help to assess human exposure to airborne pathogens. However, there is as yet limited quantified evidence that modelled concentrations are indeed associated to observed human incidence.We correlated human Q fever (caused by the bacterium Coxiella burnetii) incidence data in the Netherlands to modelled concentrations from

2015 International journal of health geographics

144. Long-Term Serological Follow-Up of Acute Q-Fever Patients after a Large Epidemic Full Text available with Trip Pro

Long-Term Serological Follow-Up of Acute Q-Fever Patients after a Large Epidemic Serological follow-up of acute Q-fever patients is important for detection of chronic infection but there is no consensus on its frequency and duration. The 2007-2009 Q-fever epidemic in the Netherlands allowed for long-term follow-up of a large cohort of acute Q-fever patients. The aim of this study was to validate the current follow-up strategy targeted to identify patients with chronic Q-fever.A cohort of adult (...) acute Q-fever patients, diagnosed between 2007 and 2009, for whom a twelve-month follow-up sample was available, was invited to complete a questionnaire and provide a blood sample, four years after the acute episode. Antibody profiles, determined by immunofluorescence assay in serum, were investigated with a special focus on high titres of IgG antibodies against phase I of Coxiella burnetii, as these are considered indicative for possible chronic Q-fever.Of the invited 1,907 patients fulfilling

2015 PloS one

145. What's new in Q fever? (Abstract)

What's new in Q fever? Q fever is a worldwide zoonotic infection with an epidemiological pattern consisting of sporadic cases, endemic situations and outbreaks of unsuspected magnitude, as occurred in Holland. This event highlighted the fact that the term "chronic Q fever" is misleading and should be avoided. Here, we review recent advances in the understanding and management of this disease. There have been clonal outbreaks of confirmed "geotypes," such as the outbreaks in French Guiana, where (...) a very high incidence was restricted to one city, with a specific clinical expression, an unusual serological response and a putative common reservoir. The advent of positron emission tomography has improved the diagnosis of endocarditis, vascular and osteoarticular infections. Molecular tests, including fluorescent in situ hybridization, may be included in the diagnostic strategy using the new criteria for endocarditis, vascular and osteoarticular infections. Q fever during pregnancy is challenging

2015 Journal of Infection

146. Familial Q fever clustering with variable manifestations imitating infectious and autoimmune disease. Full Text available with Trip Pro

Familial Q fever clustering with variable manifestations imitating infectious and autoimmune disease. Q fever, caused by Coxiella burnetii, can present as an outbreak of acute disease ranging from asymptomatic disease, pneumonia, hepatitis or fever of unknown origin, which can progress to a chronic disease, most frequently endocarditis. The occurrence of Q fever within families is rarely described, and in most cases presents with uniform acute disease manifestations. Here we present a familial (...) cluster of Q fever presenting as highly variable synchronous manifestations in four of five family members, including prolonged fever of unknown origin, asymptomatic carrier state, hepatitis, and chronic endocarditis developing in the absence of previous symptoms. This case series highlights the possibility of Q fever developing in cohabitated individuals with highly variable symptoms masking the common disease etiology. Screening of all exposed individuals, even those not clinically suspected

2015 Clinical Microbiology and Infection

147. Rainfall and Sloth Births in May, Q Fever in July, Cayenne, French Guiana. Full Text available with Trip Pro

Rainfall and Sloth Births in May, Q Fever in July, Cayenne, French Guiana. Q fever in French Guiana is correlated with the rainy season. We found a 1- to 2-month lagged correlation between Q fever incidence and the number of births of three-toed sloth. This result strengthens the hypothesis that the three-toed sloth is the wild reservoir of Q fever in French Guiana.© The American Society of Tropical Medicine and Hygiene.

2015 American Journal of Tropical Medicine & Hygiene

148. Nationwide registry-based ecological analysis of Q fever incidence and pregnancy outcome during an outbreak in the Netherlands. Full Text available with Trip Pro

Nationwide registry-based ecological analysis of Q fever incidence and pregnancy outcome during an outbreak in the Netherlands. Whether areas affected by Q fever during a large outbreak (2008-2010) had higher rates of adverse pregnancy outcomes than areas not affected by Q fever.Nationwide registry-based ecological study.Pregnant women in areas affected and not affected by Q fever in the Netherlands, 2003-2004 and 2008-2010.Index group (N=58,737): pregnant women in 307 areas with more than two (...) Q fever notifications. Reference group (N=310,635): pregnant women in 921 areas without Q fever notifications. As a baseline, pregnant women in index and reference areas in the years 2003-2004 were also included in the reference group to estimate the effect of Q fever in 2008-2010, and not the already existing differences before the outbreak.Preterm delivery, small for gestational age, perinatal mortality.In 2008-2010, there was no association between residing in a Q fever-affected area and both

2015 BMJ open

149. Delayed Diagnosis of Q Fever: Finally Diagnosed After Elective Cardiac Surgery. (Abstract)

Delayed Diagnosis of Q Fever: Finally Diagnosed After Elective Cardiac Surgery. Q fever is a bacterial infection caused by Coxiella burnetti. It can cause both acute and chronic illness. Chronic QF can present as a variety of clinical syndromes. A common and critical manifestation is endocarditis which can present atypically and is easily missed. This case describes a man who, after extensive investigation for splenomegaly and pancytopenia by several specialties, was finally diagnosed with Q (...) fever endocarditis after unexpected aortic valve abnormalities found during elective cardiac surgery. Several factors contributed to diagnostic delay including aspects of clinical assessment and radiologic findings. Vigilance is essential for diagnosis and prompt initiation of effective treatment. Copyright © 2015 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

2015 Annals of Thoracic Surgery

150. The Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii Full Text available with Trip Pro

The Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii Q fever is a highly infectious disease with a worldwide distribution. Its causative agent, the intracellular bacterium Coxiella burnetii, infects a variety of vertebrate species, including humans. Its evolutionary origin remains almost entirely unknown and uncertainty persists regarding the identity and lifestyle of its ancestors. A few tick species were recently (...) found to harbor maternally-inherited Coxiella-like organisms engaged in symbiotic interactions, but their relationships to the Q fever pathogen remain unclear. Here, we extensively sampled ticks, identifying new and atypical Coxiella strains from 40 of 58 examined species, and used this data to infer the evolutionary processes leading to the emergence of C. burnetii. Phylogenetic analyses of multi-locus typing and whole-genome sequencing data revealed that Coxiella-like organisms represent

2015 PLoS pathogens

151. First Draft Genome Sequence of a Human Coxiella burnetii Isolate, Originating from the Largest Q Fever Outbreak Ever Reported, the Netherlands, 2007 to 2010 Full Text available with Trip Pro

First Draft Genome Sequence of a Human Coxiella burnetii Isolate, Originating from the Largest Q Fever Outbreak Ever Reported, the Netherlands, 2007 to 2010 In 2009, Coxiella burnetii caused a large regional outbreak of Q fever in South Limburg, the Netherlands. Here, we announce the genome draft sequence of a human C. burnetii isolate, strain NL-Limburg, originating from this outbreak, including a brief summary of the genome's general features. Copyright © 2015 Hammerl et al.

2015 Genome Announcements

152. Limited humoral and cellular responses to Q fever vaccination in older adults with risk factors for chronic Q fever. (Abstract)

Limited humoral and cellular responses to Q fever vaccination in older adults with risk factors for chronic Q fever. In the Netherlands, people at risk for chronic Q fever were vaccinated against Coxiella burnetii with the inactivated whole cell vaccine Q-vax®. We aimed to measure the immune responses to C. burnetii six and twelve months after vaccination in this relevant population.In 260 vaccinees, antibody responses were assessed by immunofluorescence assay (IFA), complement fixation test (...) and ELISA. The cellular immune responses were assessed by measuring C. burnetii-specific interferon (IFN)-γ production in blood. Serological results of 200 individuals with past Q fever were used for comparison.At six months, 46% of vaccinees showed low IFA antibody titres and 67% had a positive IFN-γ assay; At twelve months, both were 60%. In contrast, individuals with a past Q fever were seropositive in 99.5% at six and twelve months, with relatively higher IFA titres. Interestingly, vaccinees

2013 Journal of Infection

153. A Combination of IFN-γ and IL-2 Production by Coxiella burnetii Stimulated Circulating Cells Discriminates Between Chronic Q Fever and Past Q Fever. Full Text available with Trip Pro

A Combination of IFN-γ and IL-2 Production by Coxiella burnetii Stimulated Circulating Cells Discriminates Between Chronic Q Fever and Past Q Fever. Infection with Coxiella burnetii may lead to life-threatening chronic Q fever endocarditis or vascular infections, which are often difficult to diagnose. The present study aims to investigate whether measurement of in-vitro interferon-gamma (IFN-γ) production, a key cytokine in the immune response against C. burnetii, differentiates chronic from (...) a past cleared infection, and whether measurement of other cytokines would improve the discriminative power. First, C. burnetii-specific IFN-γ production was measured in whole blood of 28 definite chronic Q fever patients and compared with 135 individuals with past Q fever (seropositive controls) and 908 seronegative controls. IFN-γ production was significantly higher in chronic Q fever patients than in controls, but with overlapping values between patients and seropositives. Secondly, the production

2013 Clinical Microbiology and Infection

154. Non-Contact Thermometers for Detecting Fever

mean tympanic (0.806; 95% CI, 0.749 to 0.849) • Sensitivity, specificity, PPV and NPV (in brackets, respectively) of each method to detect rectal fever were as follows: o right tympanic (0.682, 0.979, 0.900, 0.916) o left tympanic (0.712, 0.957, 0.825, 0.922) o mean tympanic (0.636, 0.974, 0.875, 0.905) chemotherapy. In the absence of contraindication, a corrected oral temperature (+ 0.3 ºC) measurement is a reasonable alternative.” (p. 253 to 254) Smitz, 2009, 19 Belgium • 18 patients were febrile (...) Non-Contact Thermometers for Detecting Fever TITLE: Non-Contact Thermometers for Detecting Fever: A Review of Clinical Effectiveness DATE: 20 November 2014 CONTEXT AND POLICY ISSUES Body temperature can be measured in a number of ways. Traditionally, body temperature has been measured using contact thermometers that are placed on the forehead or in the mouth, ear, armpit or rectum. 1 For children in particular, rectal temperature measurement is often considered to be the gold standard. 2 Non

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

155. Neurocognitive disturbances associated with acute infectious mononucleosis, Ross River fever and Q fever: a preliminary investigation of inflammatory and genetic correlates. (Abstract)

Neurocognitive disturbances associated with acute infectious mononucleosis, Ross River fever and Q fever: a preliminary investigation of inflammatory and genetic correlates. Disturbances in neurocognitive performance are a core feature of the acute sickness response to infection; however the underlying mechanisms remain unclear. The current study used a computerised battery to assess neurocognitive functioning in subjects enrolled in the Dubbo Infection Outcomes Study (n=107) - a prospective

2014 Brain, behavior, and immunity

156. Assessing the long-term health impact of Q-fever in the Netherlands: a prospective cohort study started in 2007 on the largest documented Q-fever outbreak to date. Full Text available with Trip Pro

Assessing the long-term health impact of Q-fever in the Netherlands: a prospective cohort study started in 2007 on the largest documented Q-fever outbreak to date. Between 2007 and 2011, the Netherlands experienced the largest documented Q-fever outbreak to date with a total of 4108 notified acute Q-fever patients. Previous studies have indicated that Q-fever patients may suffer from long-lasting health effects, such as fatigue and reduced quality of life. Our study aims to determine the long (...) -term health impact of Q-fever. It will also compare the health status of Q-fever patients with three reference groups: 1) healthy controls, 2) patients with Legionnaires' disease and 3) persons with a Q-fever infection but a-specific symptoms.Two groups of Q-fever patients were included in a prospective cohort study. In the first group the onset of illness was in 2007-2008 and participation was at 12 and 48 months. In the second group the onset of illness was in 2010-2011 and participation was at 6

2012 BMC Infectious Diseases

157. Q Fever Studies. XII. Certain Observations on the Relationships Between Serologic Tests for Brucellosis, Syphilis and Q Fever Full Text available with Trip Pro

Q Fever Studies. XII. Certain Observations on the Relationships Between Serologic Tests for Brucellosis, Syphilis and Q Fever 14894726 2004 02 15 2018 12 01 0002-9572 42 1 1952 Jan American journal of public health and the nation's health Am J Public Health Nations Health Q fever studies. XII. Certain observations on the relationships between serologic tests for brucellosis; syphilis and Q fever. 12-9 LENNETTE E H EH CLARK W H WH JENSEN F W FW eng Journal Article United States Am J Public (...) Health Nations Health 1254075 0002-9572 OM Brucellosis diagnosis Humans Q Fever diagnosis Serologic Tests Syphilis diagnosis 5221:25167:65:318:367 BRUCELLOSIS/diagnosis Q FEVER/diagnosis SYPHILIS/diagnosis 1952 1 1 1952 1 1 0 1 1952 1 1 0 0 ppublish 14894726 PMC1525824 J Am Med Assoc. 1950 Mar 25;142(12):868-72 15405990 Am J Public Health Nations Health. 1949 Apr;39(4):492-503 18118989 Am J Hyg. 1951 Nov;54(3):319-30 14885152 Calif Med. 1949 Apr;70(4):292 18116234 J Am Med Assoc. 1951 Feb 3;145(5

1952 American Journal of Public Health and the Nations Health

158. Comparative Q Fever Investigations: I. Q Fever and Related Zoonoses in an Endemic Area Full Text available with Trip Pro

Comparative Q Fever Investigations: I. Q Fever and Related Zoonoses in an Endemic Area 14200220 1996 12 01 2018 12 01 0002-9572 54 1964 Aug American journal of public health and the nation's health Am J Public Health Nations Health COMPARATIVE Q FEVER INVESTIGATIONS. I. Q FEVER AND RELATED ZOONOSES IN AN ENDEMIC AREA. 1282-8 FERRIS D H DH BRANDLY C A CA eng Journal Article United States Am J Public Health Nations Health 1254075 0002-9572 OM Agglutination Animals Brucellosis Cattle Epidemiology (...) Illinois Leptospira interrogans serovar canicola Leptospirosis Q Fever Zoonoses AGGLUTINATION BRUCELLOSIS CATTLE EPIDEMIOLOGY ILLINOIS LEPTOSPIRA CANICOLA LEPTOSPIROSIS Q FEVER 1964 8 1 1964 8 1 0 1 1964 8 1 0 0 ppublish 14200220 PMC1254965 Am J Public Health Nations Health. 1949 Apr;39(4):485-91 18118988 Public Health Rep. 1950 Apr 21;65(16):541-4 15412991 Am J Hyg. 1955 May;61(3):362-70 14376385 J Parasitol. 1952 Feb;38(1):1-5 14928145 Am J Hyg. 1959 May;69(3):202-13 13649674 J Am Vet Med Assoc. 1961

1964 American Journal of Public Health and the Nations Health

159. Comparative Q Fever Investigations: II. Brucellosis and Coxiellosis (Q Fever) Reactors in a University Cohort Full Text available with Trip Pro

Comparative Q Fever Investigations: II. Brucellosis and Coxiellosis (Q Fever) Reactors in a University Cohort 14200221 1996 12 01 2018 12 01 0002-9572 54 1964 Aug American journal of public health and the nation's health Am J Public Health Nations Health COMPARATIVE Q FEVER INVESTIGATIONS. II. BRUCELLOSIS AND COXIELLOSIS (Q FEVER) REACTORS IN A UNIVERSITY COHORT. 1289-92 FERRIS D H DH CAVINS E W EW VINCI A J AJ WATSON F R FR eng Journal Article United States Am J Public Health Nations Health (...) 1254075 0002-9572 OM Adolescent Agglutination Brucellosis Epidemiology Humans Illinois Q Fever United States Universities ADOLESCENCE AGGLUTINATION BRUCELLOSIS EPIDEMIOLOGY ILLINOIS Q FEVER UNITED STATES 1964 8 1 1964 8 1 0 1 1964 8 1 0 0 ppublish 14200221 PMC1254966 J Am Med Assoc. 1951 Feb 3;145(5):306-9 14794441 J Immunol. 1953 Oct;71(4):226-31 13096763 Lancet. 1953 Sep 19;265(6786):616-7 13098019 J Immunol. 1955 Mar;74(3):222-7 14354204 Am J Hyg. 1957 May;65(3):239-47 13424514 J Am Vet Med Assoc

1964 American Journal of Public Health and the Nations Health

160. Epidemiology of Spotted Fever Group Rickettsioses and Acute Undifferentiated Febrile Illness in Villeta, Colombia. Full Text available with Trip Pro

Epidemiology of Spotted Fever Group Rickettsioses and Acute Undifferentiated Febrile Illness in Villeta, Colombia. Etiology of acute undifferentiated febrile syndrome (AUFS) is often unknown, leading to inaccurate diagnosis and treatment. Villeta town has been identified as an endemic area for spotted fever group (SFG) rickettsioses but little is known about possible amplifier hosts and other Rickettsia species different from Rickettsia rickettsii. Besides, few studies have approached other (...) AUFS etiologies in the region. We investigated the role of dengue, leptospirosis, rickettsioses, human anaplasmosis, and Q fever as possible causes of AUFS in patients from Villeta. Sera specimens and ticks from animals as well as ticks from vegetation were studied for the presence of different Rickettsia spp. Among 104 sera from patients with AUFS, 16.4%, 24.0%, and 2.9% patients seroconverted to dengue, Leptospira, and SFG Rickettsia, respectively, with a case of probable coinfection or cross

2017 American Journal of Tropical Medicine & Hygiene

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