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Q Fever

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41. Maternal and Fetal outcomes of Q fever in pregnancy: a systematic review

Maternal and Fetal outcomes of Q fever in pregnancy: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2020 PROSPERO

42. Reprint of "Epidemiology of brucellosis, Q Fever and Rift Valley Fever at the human and livestock interface in northern Côte d'Ivoire". (Abstract)

Reprint of "Epidemiology of brucellosis, Q Fever and Rift Valley Fever at the human and livestock interface in northern Côte d'Ivoire". Northern Côte d'Ivoire is the main livestock breeding zone and has the highest livestock cross-border movements in Côte d'Ivoire. The aim of this study was to provide updated epidemiological data on three neglected zoonotic diseases, namely brucellosis, Q Fever and Rift Valley Fever (RVF). We conducted three-stage cross-sectional cluster surveys in livestock (...) . The seroprevalence of Brucella spp. in cattle adjusted for clustering was 4.6%. Cattle aged 5-8 years had higher odds of seropositivity (OR=3.5) than those aged ≤4years. The seropositivity in cattle was associated with having joint hygromas (OR=9), sharing the pastures with small ruminants (OR=5.8) and contact with pastoralist herds (OR=11.3). The seroprevalence of Q Fever was 13.9% in cattle, 9.4% in sheep and 12.4% in goats. The seroprevalence of RVF was 3.9% in cattle, 2.4% in sheep and 0% in goats

2017 Acta Tropica

43. Acute Q Fever Case Detection among Acute Febrile Illness Patients, Thailand, 2002-2005. Full Text available with Trip Pro

Acute Q Fever Case Detection among Acute Febrile Illness Patients, Thailand, 2002-2005. Acute Q fever cases were identified from a hospital-based acute febrile illness study conducted in six community hospitals in rural north and northeast Thailand from 2002 to 2005. Of 1,784 participants that underwent Coxiella burnetii testing, nine (0.5%) participants were identified in this case-series as acute Q fever cases. Eight case-patients were located in one province. Four case-patients were (...) hospitalized. Median age was 13 years (range: 7-69); five were male. The proportion of children with acute Q fever infection was similar to adults (P = 0.17). This previously unrecognized at-risk group, school-age children, indicates that future studies and prevention interventions should target this population. The heterogeneity of disease burden across Thailand and milder clinical presentations found in this case-series should be considered in future studies. As diagnosis based on serology is limited

2017 American Journal of Tropical Medicine & Hygiene

44. Acute Q fever in febrile patients in northwestern of Iran Full Text available with Trip Pro

Acute Q fever in febrile patients in northwestern of Iran Q fever is an endemic disease in different parts of Iran. This study aimed to investigate the prevalence of acute Q fever disease among at-risk individuals in northwestern Iran.An etiological study was carried out in 2013 in Tabriz County. A total of 116 individuals who were in contact with livestock and had a nonspecific febrile illness were enrolled in the study. IgG phase II antibodies against Coxiella burnetii were detected using (...) ELISA.The prevalence of acute Q fever was 13.8% (95% confidence interval [CI]: 8.0, 21.0%). Headache (87.5%) and fatigue and weakness (81.3%) were the dominant clinical characteristics among patients whit acute Q fever. Acute lower respiratory tract infection and chills were poorly associated with acute Q fever. Furthermore, 32% (95% CI: 24, 41%) of participants had a history of previous exposure to Q fever agent (past infection). Consumption of unpasteurized dairy products was a weak risk factor

2017 PLoS neglected tropical diseases

45. Are brucellosis, Q fever and melioidosis potential causes of febrile illness in Madagascar? Full Text available with Trip Pro

Are brucellosis, Q fever and melioidosis potential causes of febrile illness in Madagascar? Brucellosis, Q fever and melioidosis are zoonoses, which can lead to pyrexia. These diseases are often under-ascertained and underreported because of their unspecific clinical signs and symptoms, insufficient awareness by physicians and public health officers and limited diagnostic capabilities, especially in low-resource countries. Therefore, the presence of Brucella spp., Coxiella burnetii (...) and Burkholderia pseudomallei was investigated in Malagasy patients exhibiting febrile illness. In addition, we analyzed zebu cattle and their ticks as potential reservoirs for Brucella and C. burnetii, respectively. Specific quantitative real-time PCR assays (qPCRs) were performed on 1020 blood samples drawn from febrile patients. In total, 15 samples (1.5%) were Brucella-positive, mainly originating from patients without travel history, while DNA from C. burnetii and Bu. pseudomallei was not detected. Anti-C

2017 Acta Tropica

46. Lassa fever

Lassa fever Lassa fever - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Lassa fever Last reviewed: February 2019 Last updated: February 2019 Summary Notifiable condition. Early recognition, isolation of the patient, and appropriate infection control measures are a critical part of management. Asymptomatic or mild febrile illness in approximately 80% of patients, which can make diagnosis difficult. Severe symptoms (...) that she has no competing interests. Consultant in Tropical and Travel Medicine Hospitals for Tropical Diseases Senior Lecturer London School of Hygiene and Tropical Medicine London UK Disclosures RB has provided expert testimony to the courts, on behalf of the Crown, regarding Q fever. RB has been a paid member of the Advisory Board for Takeda regarding Dengue vaccine. He has been a paid member of the Advisory Board for Valneva UK regarding Ixiaro, a vaccine for Japanese encephalitis. Peer reviewers

2019 BMJ Best Practice

47. Lassa fever

Lassa fever Lassa fever - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Lassa fever Last reviewed: February 2019 Last updated: February 2019 Summary Notifiable condition. Early recognition, isolation of the patient, and appropriate infection control measures are a critical part of management. Asymptomatic or mild febrile illness in approximately 80% of patients, which can make diagnosis difficult. Severe symptoms (...) that she has no competing interests. Consultant in Tropical and Travel Medicine Hospitals for Tropical Diseases Senior Lecturer London School of Hygiene and Tropical Medicine London UK Disclosures RB has provided expert testimony to the courts, on behalf of the Crown, regarding Q fever. RB has been a paid member of the Advisory Board for Takeda regarding Dengue vaccine. He has been a paid member of the Advisory Board for Valneva UK regarding Ixiaro, a vaccine for Japanese encephalitis. Peer reviewers

2018 BMJ Best Practice

48. Assessment of fever of unknown origin in adults

?tool=bestpractice.com A subsequent qualitative definition is less specific as follows: a temperature >38.3°C (>100.9°F) on several separate occasions; an appropriate initial diagnostic work-up (inpatient or outpatient) does not reveal aetiology of fever. Hersch EC, Oh RC. Prolonged febrile illness and fever of unknown origin in adults. Am Fam Physician. 2014 Jul 15;90(2):91-6. http://www.aafp.org/afp/2014/0715/p91.html http://www.ncbi.nlm.nih.gov/pubmed/25077578?tool=bestpractice.com Fluctuations (...) , with tuberculosis and intra-abdominal and pelvic abscesses now being more commonly implicated than infective endocarditis. Hersch EC, Oh RC. Prolonged febrile illness and fever of unknown origin in adults. Am Fam Physician. 2014 Jul 15;90(2):91-6. http://www.aafp.org/afp/2014/0715/p91.html http://www.ncbi.nlm.nih.gov/pubmed/25077578?tool=bestpractice.com Roth AR, Basello GM. Approach to the adult patient with fever of unknown origin. Am Fam Physician. 2003 Dec 1;68(11):2223-8. https://www.aafp.org/afp/2003/1201

2018 BMJ Best Practice

49. Assessment of fever of unknown origin in adults

?tool=bestpractice.com A subsequent qualitative definition is less specific as follows: a temperature >38.3°C (>100.9°F) on several separate occasions; an appropriate initial diagnostic work-up (inpatient or outpatient) does not reveal aetiology of fever. Hersch EC, Oh RC. Prolonged febrile illness and fever of unknown origin in adults. Am Fam Physician. 2014 Jul 15;90(2):91-6. http://www.aafp.org/afp/2014/0715/p91.html http://www.ncbi.nlm.nih.gov/pubmed/25077578?tool=bestpractice.com Fluctuations (...) , with tuberculosis and intra-abdominal and pelvic abscesses now being more commonly implicated than infective endocarditis. Hersch EC, Oh RC. Prolonged febrile illness and fever of unknown origin in adults. Am Fam Physician. 2014 Jul 15;90(2):91-6. http://www.aafp.org/afp/2014/0715/p91.html http://www.ncbi.nlm.nih.gov/pubmed/25077578?tool=bestpractice.com Roth AR, Basello GM. Approach to the adult patient with fever of unknown origin. Am Fam Physician. 2003 Dec 1;68(11):2223-8. https://www.aafp.org/afp/2003/1201

2018 BMJ Best Practice

50. Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France

Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France (MEDVETFQ) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2017 Clinical Trials

51. A human time dose response model for Q fever Full Text available with Trip Pro

A human time dose response model for Q fever The causative agent of Q fever, Coxiella burnetii, has the potential to be developed for use in biological warfare and it is classified as a bioterrorism threat agent by the Centers for Disease Control and Prevention (CDC) and as a category B select agent by the National Institute of Allergy and Infectious Diseases (NIAID). In this paper we focus on the in-host properties that arise when an individual inhales a dose of C. burnetii and establish

2017 Epidemics

52. Seroprevalence of rickettsial infections and Q fever in Bhutan Full Text available with Trip Pro

Seroprevalence of rickettsial infections and Q fever in Bhutan With few studies conducted to date, very little is known about the epidemiology of rickettsioses in Bhutan. Due to two previous outbreaks and increasing clinical cases, scrub typhus is better recognized than other rickettsial infections and Q fever.A descriptive cross-sectional serosurvey was conducted from January to March 2015 in eight districts of Bhutan. Participants were 864 healthy individuals from an urban (30%) and a rural (...) (70%) sampling unit in each of the eight districts. Serum samples were tested by microimmunofluorescence assay for rickettsial antibodies at the Australian Rickettsial Reference Laboratory.Of the 864 participants, 345 (39.9%) were males and the mean age of participants was 41.1 (range 13-98) years. An overall seroprevalence of 49% against rickettsioses was detected. Seroprevalence was highest against scrub typhus group (STG) (22.6%) followed by spotted fever group (SFG) rickettsia (15.7%), Q fever

2017 PLoS neglected tropical diseases

53. Chronic Q Fever Infections in Israeli Children - A 25-Year Nationwide Study. (Abstract)

Chronic Q Fever Infections in Israeli Children - A 25-Year Nationwide Study. Q fever is a zoonosis caused by the bacterium Coxiella burnetii (C. burnetii) with a worldwide distribution. Our aim was to assess the epidemiology, clinical manifestations and treatment regimens of chronic Q fever infections in Israeli children during the past 25 years.Cases were collected from the national Q fever reference laboratory database. Demographic, epidemiologic and clinical data were reviewed using (...) a structured questionnaire sent to the referring physician. Cases were defined according to the new Dutch Consensus Guidelines.A total of 16 children originating from all regions of the country were found positive for chronic Q fever infections. The most common infection site was bone or joint (8/16, 50%), all in previously healthy children. Endovascular infections were found in 5 children (31%), all with an antecedent cardiac graft insertion. According to the new Consensus Guidelines, 9 children (56%) had

2017 Pediatric Infectious Dsease Journal

54. First Case of Q Fever Endocarditis Involving the Melody<sup>®</sup> Transcatheter Pulmonary Valve in an Afebrile Child. (Abstract)

First Case of Q Fever Endocarditis Involving the Melody® Transcatheter Pulmonary Valve in an Afebrile Child. In this article we report the first case of Q fever endocarditis in a 13 years old child with a percutaneous pulmonary Melody® valve. The patient had a new onset of Melody valve dysfunction associated with the combination of hepatosplenomegaly and pancytopenia but was afebrile. Although blood cultures were negative, we have further investigated in the direction of infective

2017 Pediatric Cardiology

55. CXCL9, a promising biomarker in the diagnosis of chronic Q fever. Full Text available with Trip Pro

CXCL9, a promising biomarker in the diagnosis of chronic Q fever. In the aftermath of the largest Q fever outbreak in the world, diagnosing the potentially lethal complication chronic Q fever remains challenging. PCR, Coxiella burnetii IgG phase I antibodies, CRP and 18F-FDG-PET/CT scan are used for diagnosis and monitoring in clinical practice. We aimed to identify and test biomarkers in order to improve discriminative power of the diagnostic tests and monitoring of chronic Q fever.We (...) performed a transcriptome analysis on C. burnetii stimulated PBMCs of 4 healthy controls and 6 chronic Q fever patients and identified genes that were most differentially expressed. The gene products were determined using Luminex technology in whole blood samples stimulated with heat-killed C. burnetii and serum samples from chronic Q fever patients and control subjects.Gene expression of the chemokines CXCL9, CXCL10, CXCL11 and CCL8 was strongly up-regulated in C. burnetii stimulated PBMCs of chronic Q

2017 BMC Infectious Diseases

56. Thrombosis and antiphospholipid antibody syndrome during acute Q fever: A cross-sectional study. Full Text available with Trip Pro

Thrombosis and antiphospholipid antibody syndrome during acute Q fever: A cross-sectional study. Q fever is a neglected and potentially fatal disease. During acute Q fever, antiphospholipid antibodies are very prevalent and have been associated with fever, thrombocytopenia, acquired heart valve disease, and progression to chronic endocarditis. However, thrombosis, the main clinical criterion of the 2006 updated classification of the antiphospholipid syndrome, has not been assessed (...) in this context. To test whether thrombosis is associated with antiphospholipid antibodies and whether the criteria for antiphospholipid syndrome can be met in patients with acute Q fever, we conducted a cross-sectional study at the French National Referral Center for Q fever.Patients included were diagnosed with acute Q fever in our Center between January 2007 and December 2015. Each patient's history and clinical characteristics were recorded with a standardized questionnaire. Predictive factors associated

2017 Medicine

57. Remarkable spatial variation in the seroprevalence of Coxiella burnetii after a large Q fever epidemic. Full Text available with Trip Pro

Remarkable spatial variation in the seroprevalence of Coxiella burnetii after a large Q fever epidemic. Prior to the 2007-2010 Q fever epidemic in the Netherlands, the seroprevalence of antibodies against Coxiella burnetii in the general population was 1.5%, which is low compared to other countries. We aimed to determine the seroprevalence after the Q fever epidemic among people living in the affected area, compare the seroprevalence with the incidence of Q fever notifications during the 2007 (...) -2010 Q fever epidemic, and to identify farm exposures associated with having antibodies against C. burnetii.During the period March 2014-February 2015, residents aged 18-70 years from two provinces were invited by general practitioners to complete a questionnaire on their symptoms and personal characteristics and to submit a blood sample. We used the mandatory provincial database of livestock licences to calculate distance to farms/farm animals for each participant. To compare ELISA-positive

2017 BMC Infectious Diseases

58. Surveillance for Q Fever Endocarditis in the United States, 1999-2015. Full Text available with Trip Pro

Surveillance for Q Fever Endocarditis in the United States, 1999-2015. Q fever is a worldwide zoonosis caused by Coxiella burnetii. In some persons, particularly those with cardiac valve disease, infection with C. burnetii can cause a life-threatening infective endocarditis. There are few descriptive analyses of Q fever endocarditis in the United States.Q fever case report forms submitted during 1999-2015 were reviewed to identify reports describing endocarditis. Cases were categorized (...) . Eight patients with endocarditis had phase I immunoglobulin G antibody titers >800 but did not meet the CSTE case definition for Q fever endocarditis.These data summarize a limited set of clinical and epidemiological features of Q fever endocarditis collected through passive surveillance in the United States. Some cases of apparent Q fever endocarditis could not be classified by CSTE laboratory criteria, suggesting that comparison of phase I and phase II titers could be reexamined as a surveillance

2017 Clinical Infectious Diseases

59. Breast implant Q fever as a source of in hospital transmission. Full Text available with Trip Pro

Breast implant Q fever as a source of in hospital transmission. Herein, we describe the first case of mammary implant infection caused by Coxiella burnetii, resulting in delayed diagnosis and treatment and an in-hospital cross-transmission of Q fever to medical personnel.

2017 Clinical Infectious Diseases

60. Treatment of chronic Q fever: clinical efficacy and toxicity of antibiotic regimens. Full Text available with Trip Pro

Treatment of chronic Q fever: clinical efficacy and toxicity of antibiotic regimens. Evidence on the effectiveness of first-line treatment for chronic Q fever, tetracyclines (TET) plus hydroxychloroquine (HCQ), and potential alternatives is scarce.We performed a retrospective, observational cohort study to assess efficacy of treatment with TET plus quinolones (QNL), TET plus QNL plus HCQ, QNL monotherapy, or TET monotherapy compared to TET plus HCQ in chronic Q fever patients. We used a time (...) -dependent Cox proportional hazards model to assess our primary (all-cause mortality) and secondary outcomes (first disease-related event and therapy failure).We assessed 322 chronic Q fever patients; 276 (86%) received antibiotics. Compared to TET plus HCQ (n = 254; 92%), treatment with TET plus QNL (n = 49; 17%), TET plus QNL plus HCQ (n = 29, 10%), QNL monotherapy (n = 93; 34%), or TET monotherapy (n = 54; 20%) were not associated with primary or secondary outcomes. QNL and TET monotherapies were

2017 Clinical Infectious Diseases

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