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Pyoderma Gangrenosum

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2. Risk of Developing Pyoderma Gangrenosum after Procedures in Patients with a Known History of Pyoderma Gangrenosum - A Retrospective Analysis. (PubMed)

Risk of Developing Pyoderma Gangrenosum after Procedures in Patients with a Known History of Pyoderma Gangrenosum - A Retrospective Analysis. The risk of postoperative pyoderma gangrenosum (PG) in patients with a known history of PG is unknown.To quantify risk and identify patient- and/or procedure-related risk factors for postsurgical recurrence or exacerbation of PG in patients with a known history of PG.We retrospectively evaluated the likelihood of postsurgical recurrence or exacerbation

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2017 Journal of American Academy of Dermatology

3. Comparison of Clinical Features between Pyoderma Gangrenosum Concomitant by Inflammatory Bowel Disease and Idiopathic Pyoderma Gangrenosum (PubMed)

Comparison of Clinical Features between Pyoderma Gangrenosum Concomitant by Inflammatory Bowel Disease and Idiopathic Pyoderma Gangrenosum Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that is highly associated with inflammatory bowel disease (IBD). Certain PG patients with no systemic disorders have been diagnosed with idiopathic PG. This study sought to clarify the difference between PG with IBD and idiopathic PG based on clinical features, laboratory tests

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2017 Chinese medical journal

4. Two drugs only partially helpful for pyoderma gangrenosum

Two drugs only partially helpful for pyoderma gangrenosum Two drugs only partially helpful for pyoderma gangrenosum Discover Portal Discover Portal Two drugs only partially helpful for pyoderma gangrenosum Published on 28 September 2015 doi: This NIHR trial found no difference in the healing of pyoderma gangrenosum over six weeks in adults treated with prednisolone or ciclosporin. Pyoderma gangrenosum is a rare serious skin condition causing painful ulcers, and over half of ulcers had failed (...) to heal after six months of either treatment. There were more serious side effects – mostly serious infections – in patients using prednisolone, though both drugs caused some harms in two thirds of patients. With little to choose between the drugs for benefit, it may be best to select the treatment based on the features of individuals that make them prone to the different adverse effects of each drug. Share your views on the research. Why was this study needed? Pyoderma gangrenosum is a rare skin

2018 NIHR Dissemination Centre

5. Two drugs only partially helpful for pyoderma gangrenosum

Two drugs only partially helpful for pyoderma gangrenosum Two drugs only partially helpful for pyoderma gangrenosum Discover Portal Discover Portal Two drugs only partially helpful for pyoderma gangrenosum Published on 28 September 2015 doi: This NIHR trial found no difference in the healing of pyoderma gangrenosum over six weeks in adults treated with prednisolone or ciclosporin. Pyoderma gangrenosum is a rare serious skin condition causing painful ulcers, and over half of ulcers had failed (...) to heal after six months of either treatment. There were more serious side effects – mostly serious infections – in patients using prednisolone, though both drugs caused some harms in two thirds of patients. With little to choose between the drugs for benefit, it may be best to select the treatment based on the features of individuals that make them prone to the different adverse effects of each drug. Share your views on the research. Why was this study needed? Pyoderma gangrenosum is a rare skin

2018 NIHR Dissemination Centre

6. Drug-induced pyoderma gangrenosum: a model to understand the pathogenesis of pyoderma gangrenosum. (PubMed)

Drug-induced pyoderma gangrenosum: a model to understand the pathogenesis of pyoderma gangrenosum. Pyoderma gangrenosum (PG) is a rare autoinflammatory condition in which the alteration of neutrophil function and the innate immune response play key roles in its pathogenesis. Cases of PG have been reported in patients being treated with certain medications, which may help us to understand some of the possible pathways involved in the aetiology of PG. The aim of this review is to review the cases (...) of PG triggered by certain drugs and try to thoroughly understand the pathogenesis of the disease. To accomplish this, a PubMed search was completed using the following words: pyoderma gangrenosum, neutrophilic dermatosis, pathophysiology, drug-induced pyoderma gangrenosum. In total, we found 43 cases of drug-induced PG. Most of them were caused by colony-stimulating factors and small-molecule tyrosine kinase inhibitors. We propose that drugs induce PG through various mechanisms

2016 British Journal of Dermatology

7. Overall and Subgroup Prevalence of Pyoderma Gangrenosum Among Patients with Hidradenitis Suppurativa: a population based analysis in the United States. (PubMed)

Overall and Subgroup Prevalence of Pyoderma Gangrenosum Among Patients with Hidradenitis Suppurativa: a population based analysis in the United States. Hidradenitis suppurativa (HS) and pyoderma gangrenosum (PG) are reported to coexist, although prevalence of PG among HS patients has not been systematically evaluated.To evaluate PG prevalence among HS patients.Cross-sectional analysis of adults with PG among HS and non-HS patients using electronic health records data from a population-based

2019 Journal of the American Academy of Dermatology

8. Absence of donor-site pathergy following fractional autologous full-thickness skin grafting in pyoderma gangrenosum. (PubMed)

Absence of donor-site pathergy following fractional autologous full-thickness skin grafting in pyoderma gangrenosum. Pyoderma gangrenosum (PG) is an uncommon inflammatory skin disorder, often associated with arthritis, inflammatory bowel disease, and/or hematologic malignancies [1]. A classic feature of PG is the development or worsening of lesions at areas that experience trauma, also known as pathergy. Autologous skin grafting may be challenging in these patients due to the potential

2019 British Journal of Dermatology

9. Clinical factors influencing the response to intravenous immunoglobulin treatment in cases of treatment-resistant pyoderma gangrenosum. (PubMed)

Clinical factors influencing the response to intravenous immunoglobulin treatment in cases of treatment-resistant pyoderma gangrenosum. Pyoderma gangrenosum (PG) is a neutrophilic disorder which classically presents as chronic, painful ulcers on the lower extremities. There is evidence supporting a potential role for intravenous immunoglobulin (IVIG) as adjuvant therapy for treatment-resistant cases; however, it is unclear which patients will most benefit from this modality of treatment (...) - an especially important consideration given the cost per infusion ($5000-$10,000). Thus, we sought to identify the clinical characteristics of patients with refractory PG lesions who demonstrated complete healing when IVIG was incorporated into the therapeutic plan.We performed a literature search of PubMed/MEDLINE and Embase using the keywords 'pyoderma gangrenosum' and 'IVIG'. We also added four institutional cases. Descriptive statistics were used to analyze the data. Significance was set at p < .05.We

2019 Journal of Dermatological Treatment

10. Pyoderma gangrenosum after cesarean section treated with skin graft: A case report. (PubMed)

Pyoderma gangrenosum after cesarean section treated with skin graft: A case report. Pyoderma gangrenosum (PG) is a rare skin disease. Pregnancy is a unique physiological condition. Here we report a rare case of PG after cesarean section.A 32-year-old female presented with wound breakdown 1 day after cesarean section, with progression to a skin ulcer and no response to antibiotic therapy.We experienced a case of PG after cesarean section. This was initially misdiagnosed as a wound infection

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2019 Medicine

11. Comment on 'Bullous pyoderma gangrenosum secondary to underlying multiple myeloma: treated with ciclosporin'. (PubMed)

Comment on 'Bullous pyoderma gangrenosum secondary to underlying multiple myeloma: treated with ciclosporin'. 31162845 2019 07 08 1365-2230 2019 Jun 04 Clinical and experimental dermatology Clin. Exp. Dermatol. Comment on 'Bullous pyoderma gangrenosum secondary to underlying multiple myeloma: treated with ciclosporin'. 10.1111/ced.14019 Mathivanan B R BR https://orcid.org/0000-0002-5324-1559 Department of Dermatology, Venereology and Leprology, All India Institute of Medical Sciences, Jodhpur

2019 Clinical & Experimental Dermatology

12. Disseminated sporotrichosis following iatrogenic immunosuppression for suspected pyoderma gangrenosum. (PubMed)

Disseminated sporotrichosis following iatrogenic immunosuppression for suspected pyoderma gangrenosum. Sporotrichosis is an infection caused by the dimorphic fungus Sporothrix schenckii and related species that often arises from traumatic inoculation of inhabited soil and organic debris into skin. The infection is usually limited to the skin in immunocompetent patients, usually as lymphocutaneous sporotrichosis. Accurate diagnosis rests on clinical data and culture, and might be facilitated (...) by biopsy identification of suppurative and granulomatous inflammation with fungal elements. In this Grand Round, we present a dramatic case of cutaneous sporotrichosis initially presented with an atypical large ulcer without associated lymphocutaneous spread, clinically mimicking pyoderma gangrenosum, and subsequently progressed to disseminated sporotrichosis in the setting of iatrogenic immunosuppression. We further review the clinical features, risk factors, and treatment of these disseminated

2019 Lancet infectious diseases

13. Paraneoplastic pyoderma gangrenosum in solid organ malignancy: a literature review. (PubMed)

Paraneoplastic pyoderma gangrenosum in solid organ malignancy: a literature review. Pyoderma gangrenosum (PG) is a rare destructive, ulcerative, and inflammatory cutaneous disease. PG can be associated with inflammatory bowel disease (IBD), arthritis, autoinflammatory syndromes, and hematological malignancies. Multiple reports in the literature have found an association between PG and solid organ tumors. This article provides a summary and review of PG in patients with solid organ malignancies (...) . We performed a PubMed search using the terms pyoderma gangrenosum, paraneoplastic pyoderma gangrenosum, cancer, malignancy, tumor, and solid organ malignancy. Out of 529 papers screened, 19 relevant cases were included that reported patients above the age of 12 years old with antecedent, coincident, or subsequent occurrence of PG in association with a solid organ malignancy. The most common malignancies associated with PG were found in the breast (n = 6, 31.6%). In a majority of the cases

2019 International Journal of Dermatology

14. Prevalence estimates for pyoderma gangrenosum in the United States: An age- and sex-adjusted population analysis. (PubMed)

Prevalence estimates for pyoderma gangrenosum in the United States: An age- and sex-adjusted population analysis. The disease burden of pyoderma gangrenosum (PG) is poorly understood.To determine standardized overall and age-, sex-, and race-specific prevalence estimates for PG among adults in the United States.Cross-sectional analysis of 1971 patients with PG identified using electronic health records data from a diverse population-based sample of more than 58 million patients.The age- and sex

2019 Journal of American Academy of Dermatology

15. Pyoderma Gangrenosum in Hematologic Malignancies: Systematic Review. (PubMed)

Pyoderma Gangrenosum in Hematologic Malignancies: Systematic Review. Pyoderma gangrenosum (PG) is a devastating neutrophilic dermatosis that may be associated with trauma or systemic diseases. The associations, characteristics, and temporal relationship of PG with hematologic malignancies are not well understood.To perform a systematic review of PG associated with hematologic malignancies using data from case reports, case series, and retrospective studies.We searched MEDLINE, EBASE, Scopus

2019 Journal of American Academy of Dermatology

16. Central retinal arterial occlusion in a patient with pyoderma gangrenosum (PubMed)

Central retinal arterial occlusion in a patient with pyoderma gangrenosum A 74-year-old male presented to us with a history of vision loss for 36 hours in the right eye (RE). The RE had a visual acuity of hand movements. The fundus revealed a pale retina, cattle tracking in the retinal vessels, and a cherry-red spot at the macula. The patient was a known case of pyoderma gangrenosum (PG) and had received intravenous methylprednisolone and cyclophosphamide at the onset of visual symptoms

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2018 Indian journal of ophthalmology

17. Improvement of Ulcerations in Treatment-Resistant Chronic Scarring in a Patient with Pyoderma Gangrenosum After Improving Vascular Insufficiency, Gently Removing Necrotic Debris, and Decreasing Wound Fluid (PubMed)

Improvement of Ulcerations in Treatment-Resistant Chronic Scarring in a Patient with Pyoderma Gangrenosum After Improving Vascular Insufficiency, Gently Removing Necrotic Debris, and Decreasing Wound Fluid BACKGROUND Classical pyoderma gangrenosum is a rare, inflammatory, neutrophilic dermatosis that commonly presents with severe ulcerations on the lower extremities and is often misdiagnosed and mistreated. Delay in treatments can lead to worsening of the ulcerations and allows for multiple (...) comorbid factors. Pyoderma gangrenosum is most commonly treated with immunosuppressants or anti-inflammatory agents and is often worsened by surgical procedures due to the presence of pathergy. In acute cases, a course of anti-inflammatory treatments works well in alleviating symptoms and reducing ulcerations and residual scarring. However, in chronic cases with the presence of severe scarring and necrotic ulcerations, the simple implementation of systemic immunosuppressants is frequently ineffective

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2018 The American journal of case reports

18. A systematic review of pyoderma gangrenosum with pulmonmary involvement: clinical presentation, diagnosis, and management. (PubMed)

A systematic review of pyoderma gangrenosum with pulmonmary involvement: clinical presentation, diagnosis, and management. 29377399 2018 06 26 1468-3083 32 7 2018 Jul Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol A systematic review of pyoderma gangrenosum with pulmonary involvement: clinical presentation, diagnosis and management. e295-e297 10.1111/jdv.14828 Gupta A S AS School of Medicine, Virginia Commonwealth University, 1101 E Marshall

2018 Journal of the European Academy of Dermatology and Venereology

19. Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. (PubMed)

Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. 30447323 2019 03 16 1097-6787 80 4 2019 Apr Journal of the American Academy of Dermatology J. Am. Acad. Dermatol. JAAD Game Changers: Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. 1178 S0190-9622(18)32880-9 10.1016/j.jaad.2018.11.003 Lake Eden E Maywood, Illinois. Electronic address: Eden.Lake

2018 Journal of American Academy of Dermatology

20. Pyoderma gangrenosum and its impact on quality of life: a multicentre, prospective study. (PubMed)

Pyoderma gangrenosum and its impact on quality of life: a multicentre, prospective study. 30362501 2019 03 01 1365-2133 180 3 2019 Mar The British journal of dermatology Br. J. Dermatol. Pyoderma gangrenosum and its impact on quality of life: a multicentre, prospective study. 672-673 10.1111/bjd.17347 Ighani A A http://orcid.org/0000-0002-2164-3609 Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Al-Mutairi D D Division of Dermatology, Department of Medicine, University

2018 British Journal of Dermatology

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