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1. Antibiotic use for irreversible pulpitis. (Abstract)

Antibiotic use for irreversible pulpitis. Irreversible pulpitis, which is characterised by acute and intense pain, is one of the most frequent reasons that patients attend for emergency dental care. Apart from removal of the tooth, the customary way of relieving the pain of irreversible pulpitis is by drilling into the tooth, removing the inflamed pulp (nerve) and cleaning the root canal. However, a significant number of dentists continue to prescribe antibiotics to stop the pain (...) of bias, illustrates that there is insufficient evidence to determine whether antibiotics reduce pain or not compared to not having antibiotics. The results of this review confirm the necessity for further larger sample and methodologically sound trials that can provide additional evidence as to whether antibiotics, prescribed in the preoperative phase, can affect treatment outcomes for irreversible pulpitis.

2019 Cochrane

2. Vital Pulp Therapy using Bioceramic Materials Is a Treatment Option for Patients Presenting with Reversible or Irreversible Pulpitis

Vital Pulp Therapy using Bioceramic Materials Is a Treatment Option for Patients Presenting with Reversible or Irreversible Pulpitis UTCAT3417, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Vital Pulp Therapy using Bioceramic Materials Is a Treatment Option for Patients Presenting with Reversible or Irreversible Pulpitis Clinical Question For patients presenting with reversible or irreversible pulpitis in mature (...) teeth, do pulpotomies performed with bioceramic materials have long-term successful outcomes compared to nonsurgical root canal therapy (NS-RCT)? Clinical Bottom Line For mature teeth (teeth with closed apices) diagnosed with reversible or irreversible pulpitis, there is sufficient evidence to support vital pulp therapy using bioceramic material as a long-term alternative to root canal therapy. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient

2020 UTHSCSA Dental School CAT Library

3. Microbiome of Deep Dentinal Caries from Reversible Pulpitis to Irreversible Pulpitis. (Abstract)

Microbiome of Deep Dentinal Caries from Reversible Pulpitis to Irreversible Pulpitis. This study examined the identity of the microbiome of deep dentinal caries and its correlation with the inflammation status of caries-induced pulpitis.Seventy-five cases were diagnosed based on the American Association of Endodontics's diagnostic criteria and divided into 4 groups: normal pulp with deep caries (NP; n = 13), reversible pulpitis with only cold-evoked pain (CRP; n = 17), reversible pulpitis (...) with both cold/heat-evoked pain (CHRP; n = 24), and symptomatic irreversible pulpitis (SIP; n = 21). Samples were sequenced by 16S rDNA. Alpha and beta diversity were determined. Linear discriminant analysis effect size (LEfSe) analysis was used to detect intergroup differences, and receiver operating characteristic (ROC) curves were generated to assess the role of the caries microbiome in caries-induced pulpitis.The 16S rDNA sequencing yielded 9100 operational taxonomic units. Lactobacillus had

2019 Journal of Endodontics

4. Antibiotic use for irreversible pulpitis. (Abstract)

Antibiotic use for irreversible pulpitis. Irreversible pulpitis, which is characterised by acute and intense pain, is one of the most frequent reasons that patients attend for emergency dental care. Apart from removal of the tooth, the customary way of relieving the pain of irreversible pulpitis is by drilling into the tooth, removing the inflamed pulp (nerve) and cleaning the root canal. However, a significant number of dentists continue to prescribe antibiotics to stop the pain (...) outcomes for irreversible pulpitis.

2016 Cochrane

5. Buffered Lidocaine Does Not Improve the Inferior Alveolar Block Success For Mandibular Posterior Teeth With Symptomatic Irreversible Pulpitis

Buffered Lidocaine Does Not Improve the Inferior Alveolar Block Success For Mandibular Posterior Teeth With Symptomatic Irreversible Pulpitis UTCAT2946, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Buffered Lidocaine Does Not Improve the Inferior Alveolar Block Success For Mandibular Posterior Teeth With Symptomatic Irreversible Pulpitis Clinical Question For patients with symptomatic irreversible pulpitis (...) , is Lidocaine buffered with Sodium Bicarbonate a more successful anesthetic compared to conventional non-buffered Lidocaine when administered as an inferior alveolar nerve block? Clinical Bottom Line Buffered Lidocaine for inferior alveolar nerve (IAN) block does not result in statistically significant increased success rate of IAN block or decrease in injection pain on mandibular posterior teeth with symptomatic irreversible pulpitis. Best Evidence (you may view more info by clicking on the PubMed ID link

2015 UTHSCSA Dental School CAT Library

6. Irreversible pulpitis: What is the most effective local anaesthetic for inferior alveolar nerve block?

Irreversible pulpitis: What is the most effective local anaesthetic for inferior alveolar nerve block? Irreversible pulpitis: What is the most effective local anaesthetic for inferior alveolar nerve block? - National Elf Service Search National Elf Service Search National Elf Service » » » » Irreversible pulpitis: What is the most effective local anaesthetic for inferior alveolar nerve block? Mar 1 2019 Posted by Effective local anaesthesia is important in order to undertake root canal (...) treatment. If inadequate this can result in pain, increase fear and anxiety and prolong treatment time. Anaesthesia for mandibular teeth with irreversible pulpitis is usually achieved using inferior alveolar nerve block which has a failure rate estimated to vary between 43-83%. Supplemental techniques such as buccal infiltration, periodontal ligament injection, intra osseous injection and oral premedication have been shown to improve anaesthesia success. However, identifying the most effective

2019 The Dental Elf

7. Antibiotic use for irreversible pulpitis. (Abstract)

Antibiotic use for irreversible pulpitis. Irreversible pulpitis, which is characterised by acute and intense pain, is one of the most frequent reasons that patients attend for emergency dental care. Apart from removal of the tooth, the customary way of relieving the pain of irreversible pulpitis is by drilling into the tooth, removing the inflamed pulp (nerve) and cleaning the root canal. However, a significant number of dentists continue to prescribe antibiotics to stop the pain (...) trial assessed as a low risk of bias, illustrates that there is insufficient evidence to determine whether antibiotics reduce pain or not compared to not having antibiotics. The results of this review confirm the necessity for further larger sample and methodologically sound trials that can provide additional evidence as to whether antibiotics, prescribed in the preoperative phase, can affect treatment outcomes for irreversible pulpitis.

2013 Cochrane

8. Preemptive Nonsteroidal Anti-Inflammatory Drugs May Increase the Success Rate of Inferior Alveolar Nerve Blocks in Mandibular Posterior Teeth with Symptomatic Irreversible Pulpitis

Preemptive Nonsteroidal Anti-Inflammatory Drugs May Increase the Success Rate of Inferior Alveolar Nerve Blocks in Mandibular Posterior Teeth with Symptomatic Irreversible Pulpitis UTCAT2807, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Preemptive Nonsteroidal Anti-Inflammatory Drugs May Increase the Success Rate of Inferior Alveolar Nerve Blocks in Mandibular Posterior Teeth with Symptomatic Irreversible Pulpitis (...) Clinical Question In mandibular posterior teeth with symptomatic irreversible pulpitis, does a preemptive dose of an oral nonsteroidal anti-inflammatory drug (NSAID) increase the success rate of an inferior alveolar nerve block (IANB) compared to placebo? Clinical Bottom Line For patients with irreversible pulpitis in a mandibular posterior tooth, a single preemptive dose of NSAID may increase the success of IANB compared to placebo. This is supported by a meta-analysis of seven clinical trials

2015 UTHSCSA Dental School CAT Library

9. The Effect of Cryotherapy Application on the Success Rate of Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis. (Abstract)

The Effect of Cryotherapy Application on the Success Rate of Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis. This randomized clinical trial assessed the effect of preoperative intraoral cryotherapy application on the success rate of inferior alveolar nerve blocks (IANBs) in patients with symptomatic irreversible pulpitis (SIP).One hundred four patients with SIP were randomly distributed into 2 groups: control and cryotherapy groups. In the control group

2019 Journal of Endodontics Controlled trial quality: uncertain

10. The efficacy of supplemental intraseptal and buccal infiltration anesthesia in mandibular molars of patients with symptomatic irreversible pulpitis. (Abstract)

The efficacy of supplemental intraseptal and buccal infiltration anesthesia in mandibular molars of patients with symptomatic irreversible pulpitis. The aim of this randomized clinical trial was to compare the success rate of three different anesthetic techniques in mandibular molars with symptomatic irreversible pulpitis.Ninety patients with symptomatic irreversible pulpitis in mandibular molars randomly received three anesthetic techniques. Group I: an inferior alveolar nerve block (IANB (...) was significantly less and the mean value for EPT2 was significantly more in groups II and III compared with group I. The success rates for groups I, II, and III were 30.33%, 66.66%, and 80.00% respectively. Also, differences of EPT2, VAS2, and success rates were statistically significant between groups II and III.Administration of articaine as a supplemental intraseptal and BI following IANB can be considered a more successful anesthetic technique in mandibular molars with symptomatic irreversible pulpitis

2019 Clinical oral investigations Controlled trial quality: uncertain

11. Resolvin E1 Ameliorates Pulpitis by Suppressing Dental Pulp Fibroblast Activation in a Chemerin Receptor 23-dependent Manner. (Abstract)

Resolvin E1 Ameliorates Pulpitis by Suppressing Dental Pulp Fibroblast Activation in a Chemerin Receptor 23-dependent Manner. Timely resolution of pulp inflammation is a prerequisite for the healing of inflamed dental pulp. Stromal cells, particularly fibroblasts, play a critical role in the inflammation resolution process. Resolvin E1 (RvE1) is a lipid-derived endogenous proresolution molecule that mediates this resolution process. In the present study, we investigated the effects of RvE1

2019 Journal of Endodontics

12. Comparative evaluation of anesthetic efficacy of 1.8 mL and 3.6 mL of articaine in irreversible pulpitis of the mandibular molar: A randomized clinical trial. Full Text available with Trip Pro

Comparative evaluation of anesthetic efficacy of 1.8 mL and 3.6 mL of articaine in irreversible pulpitis of the mandibular molar: A randomized clinical trial. The aim of this study was to compare the anesthetic efficacy of two volumes of articaine in conventional inferior alveolar nerve block (IANB) of mandibular molars with irreversible pulpitis, and in cases of anesthetic failure, its complementation with periodontal ligament injection (PDL).Ninety patients with irreversible pulpitis (...) in 69% and 75% of the patients, respectively, for 1.8 mL and 3.6 mL (RR = 0.91, CI 95% 0.57 to 1.45, p = 0.71).Increasing the volume from 1.8 mL to 3.6 mL of the 4% articaine with 1:100,000 epinephrine in the IANB and in the PDL, did not significantly increase the success rate of pulpal anesthesia and clinical analgesia during the pulpectomy procedure. Therefore, both volumes presented a similar efficacy, though neither resulted in effective pain control during irreversible pulpitis

2019 PloS one Controlled trial quality: uncertain

13. Evaluation of postoperative pain intensity following occlusal reduction in teeth associated with symptomatic irreversible pulpitis and symptomatic apical periodontitis: a randomized clinical study. (Abstract)

Evaluation of postoperative pain intensity following occlusal reduction in teeth associated with symptomatic irreversible pulpitis and symptomatic apical periodontitis: a randomized clinical study. To assess the effect of occlusal reduction on postoperative pain following two visits root canal treatment in posterior mandibular teeth with symptomatic irreversible pulpitis and symptomatic apical periodontitis in a randomized clinical trial.This trial was conducted in the outpatient clinic (...) of the Endodontic Department of the Faculty of Oral and Dental Medicine, Cairo University in Egypt. Forty-four-patients diagnosed with symptomatic irreversible pulpitis and symptomatic apical periodontitis were randomly assigned into two equal groups. The occlusal surfaces of teeth in the intervention group were reduced; whilst those assigned to the control group were left intact. Canal instrumentation was completed in the first visit using Revo-S rotary nickel-titanium files, and pain intensity was assessed

2019 International endodontic journal Controlled trial quality: uncertain

14. Anesthetic efficacy of mental/incisive nerve block compared to inferior alveolar nerve block using 4% articaine in mandibular premolars with symptomatic irreversible pulpitis: a randomized clinical trial. (Abstract)

Anesthetic efficacy of mental/incisive nerve block compared to inferior alveolar nerve block using 4% articaine in mandibular premolars with symptomatic irreversible pulpitis: a randomized clinical trial. The aim of this study was to compare the onset, success rate, injection pain, and post-injection pain of mental/incisive nerve block (MINB) with that of inferior alveolar nerve block (IANB) using 4% articaine in mandibular premolars with symptomatic irreversible pulpitis. The accuracy (...) mandibular premolars with irreversible pulpitis. Post-injection pain with MINB was higher than with IANB.MINB and IANB with 4% articaine can be used interchangeably to anesthetize mandibular premolars with irreversible pulpitis.

2019 Clinical oral investigations Controlled trial quality: uncertain

15. Partial pulpotomy with two bioactive cements in permanent teeth of 6- to 18-year-old patients with signs and symptoms indicative of irreversible pulpitis: a noninferiority randomized controlled trial. (Abstract)

Partial pulpotomy with two bioactive cements in permanent teeth of 6- to 18-year-old patients with signs and symptoms indicative of irreversible pulpitis: a noninferiority randomized controlled trial. To compare the outcome of partial pulpotomy using two cements, ProRoot MTA (Dentsply, Tulsa Dental Specialties, Tulsa, OK, USA) and Biodentine (Septodont, Saint-Maur-des-Fossés, France), in permanent teeth of 6- to 18-year-old patients with signs and symptoms indicative of irreversible pulpitis (...) . Furthermore, the frequencies of perceptible grey discoloration caused by the cements were compared.Sixty-nine permanent first molars with signs and symptoms indicative of irreversible pulpitis, from 69 patients, were included. All operators performed partial pulpotomy under a standardized protocol. Teeth were allocated, using a website-generated number of simple randomization, to partial pulpotomy with either ProRoot MTA (37 teeth) or Biodentine (32 teeth) and were restored with composite resin

2019 International endodontic journal Controlled trial quality: predicted high

16. Personalized Cell Therapy for Pulpitis Using Autologous Dental Pulp Stem Cells and Leukocyte Platelet-rich Fibrin: A Case Report. (Abstract)

Personalized Cell Therapy for Pulpitis Using Autologous Dental Pulp Stem Cells and Leukocyte Platelet-rich Fibrin: A Case Report. Regenerative endodontic procedures have emerged as a new treatment. The aim of this case report was to describe a regenerative autologous cellular therapy using mesenchymal stem cells from inflamed dental pulp and leukocyte platelet-rich fibrin (L-PRF) in a mature tooth.A healthy 50-year-old man consulting for spontaneous dental pain was referred for endodontic (...) treatment in tooth #28, which was diagnosed with symptomatic irreversible pulpitis. Inflamed dental pulp was extracted and transported to a good manufacturing practice laboratory for the isolation and culture of dental pulp stem cells (DPSCs). L-PRF was obtained from the patient's blood and was introduced into the instrumented and disinfected root canal, and expanded DPSCs were inoculated into the clot. The cervical part of the root canal was sealed with Biodentine (Septodont, Saint-Maur-des-Fosses

2019 Journal of Endodontics

17. Effect of magnesium sulphate added to lidocaine on inferior alveolar nerve block success in patients with symptoms of irreversible pulpitis: a prospective, randomized clinical trial. (Abstract)

Effect of magnesium sulphate added to lidocaine on inferior alveolar nerve block success in patients with symptoms of irreversible pulpitis: a prospective, randomized clinical trial. To investigate the effect of magnesium sulphate used as an adjuvant to lidocaine with epinephrine local anaesthetic on the success of inferior alveolar nerve blocks (IANB) in patients with irreversible pulpitis undergoing root canal treatment.In a double-blind clinical trial, following power calculation, 124 (...) patients with symptoms of irreversible pulpitis in mandibular molar teeth were selected and initial pain data was collected using a Heft-Parker (Heft & Parker 1984) visual analogue scale. The first group (control) received IANB with 1.8 mL of a local anaesthetic solution containing 1.8% lidocaine with 1:88,000 epinephrine whist the second group (test) received IANB with 1.8 mL of an anaesthetic solution containing 1% magnesium sulphate, and 1.8% lidocaine with 1:88,000 epinephrine. Pain data

2019 International endodontic journal Controlled trial quality: uncertain

18. The Effect of Submucosal Injection of Corticosteroids on Pain Perception and Quality of Life after Root Canal Treatment of Teeth with Irreversible Pulpitis: A Randomized Clinical Trial. (Abstract)

The Effect of Submucosal Injection of Corticosteroids on Pain Perception and Quality of Life after Root Canal Treatment of Teeth with Irreversible Pulpitis: A Randomized Clinical Trial. The aim of the present investigation was to study the effect of local infiltration of corticosteroids on postoperative pain and quality of life (QOL) in teeth with irreversible pulpitis after 1-visit endodontic treatment.In this double-blind randomized clinical trial, 242 healthy patients with irreversible (...) pulpitis undergoing 1-visit endodontic treatment were included. Forty-five patients were lost during the follow-up, and the remaining 197 patients were followed for 7 days (67 patients in the placebo group, 66 in the long-acting betamethasone group, and 64 in the dexamethasone group). The patients marked their level of pain and QOL before treatment and at 6-, 12-, 24-, 48-, and 72-hour and 7-day postoperative intervals using a questionnaire. Freidman and Kruskal-Wallis tests were used for statistical

2019 Journal of Endodontics Controlled trial quality: uncertain

19. Does oral Nonsteroidal Anti-inflammatory Drugs (NSAIDs) premedication in patients with irreversible pulpitis increase the success rate of inferior alveolar nerve block? (Abstract)

Does oral Nonsteroidal Anti-inflammatory Drugs (NSAIDs) premedication in patients with irreversible pulpitis increase the success rate of inferior alveolar nerve block? Data sources PubMed, EBSCOhost and Scopus database up till 9 September 2017 in English language. Clinical trial registry and reference lists of published systematic reviews, textbooks and selected articles were also searched.Study selection Population-based randomised clinical trials comparing effects of any single NSAID versus (...) placebo as an oral premedication on the efficacy of IANB in achieving anaesthesia in patients ranging from age 14-68 with irreversible pulpitis who were undergoing nonsurgical root canal therapy in mandibular posterior teeth.Data extraction and synthesis Studies were selected, reviewed and extracted by two independent reviewers using a standardised extraction form. They assessed risk of bias using the revised Cochrane Risk of Bias Tool for Randomised Trials (ROB 2.0). Meta-analysis was performed using

2019 Evidence Based Dentistry

20. Inferior Alveolar Nerve Block: improving anaesthetic success in patients with irreversible pulpitis

Inferior Alveolar Nerve Block: improving anaesthetic success in patients with irreversible pulpitis Inferior Alveolar Nerve Block: improving anaesthetic success in patients with irreversible pulpitis - National Elf Service Search National Elf Service Search National Elf Service » » » » Inferior Alveolar Nerve Block: improving anaesthetic success in patients with irreversible pulpitis Apr 13 2018 Posted by The failure rate for inferior alveolar nerve block (IANB) in patients with irreversible (...) pulpitis is reported to be between 43-83% and related to inflammatory changes in the Pulp. The use of a variety of pharmacological agents (eg NSAIDs and steroids) to improve the success rates have been investigated. Reviews of individual agents have been published but head-to-head comparisons to assess the relative efficacy are lacking. The aim of this review was to assess which is the most effective oral premedication in increasing the anaesthetic success of Inferior Alveolar Nerve Block in patients

2018 The Dental Elf

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