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1. Antibiotic use for irreversible pulpitis. (PubMed)

Antibiotic use for irreversible pulpitis. Irreversible pulpitis, which is characterised by acute and intense pain, is one of the most frequent reasons that patients attend for emergency dental care. Apart from removal of the tooth, the customary way of relieving the pain of irreversible pulpitis is by drilling into the tooth, removing the inflamed pulp (nerve) and cleaning the root canal. However, a significant number of dentists continue to prescribe antibiotics to stop the pain (...) of bias, illustrates that there is insufficient evidence to determine whether antibiotics reduce pain or not compared to not having antibiotics. The results of this review confirm the necessity for further larger sample and methodologically sound trials that can provide additional evidence as to whether antibiotics, prescribed in the preoperative phase, can affect treatment outcomes for irreversible pulpitis.

2019 Cochrane

2. Microbiome of Deep Dentinal Caries from Reversible Pulpitis to Irreversible Pulpitis. (PubMed)

Microbiome of Deep Dentinal Caries from Reversible Pulpitis to Irreversible Pulpitis. This study examined the identity of the microbiome of deep dentinal caries and its correlation with the inflammation status of caries-induced pulpitis.Seventy-five cases were diagnosed based on the American Association of Endodontics's diagnostic criteria and divided into 4 groups: normal pulp with deep caries (NP; n = 13), reversible pulpitis with only cold-evoked pain (CRP; n = 17), reversible pulpitis (...) with both cold/heat-evoked pain (CHRP; n = 24), and symptomatic irreversible pulpitis (SIP; n = 21). Samples were sequenced by 16S rDNA. Alpha and beta diversity were determined. Linear discriminant analysis effect size (LEfSe) analysis was used to detect intergroup differences, and receiver operating characteristic (ROC) curves were generated to assess the role of the caries microbiome in caries-induced pulpitis.The 16S rDNA sequencing yielded 9100 operational taxonomic units. Lactobacillus had

2019 Journal of Endodontics

3. Antibiotic use for irreversible pulpitis. (PubMed)

Antibiotic use for irreversible pulpitis. Irreversible pulpitis, which is characterised by acute and intense pain, is one of the most frequent reasons that patients attend for emergency dental care. Apart from removal of the tooth, the customary way of relieving the pain of irreversible pulpitis is by drilling into the tooth, removing the inflamed pulp (nerve) and cleaning the root canal. However, a significant number of dentists continue to prescribe antibiotics to stop the pain (...) outcomes for irreversible pulpitis.

2016 Cochrane

4. Comparing the anaesthetic efficacy of articaine with lidocaine in patients with irreversible pulpitis: an umbrella review

Comparing the anaesthetic efficacy of articaine with lidocaine in patients with irreversible pulpitis: an umbrella review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

5. Irreversible pulpitis: What is the most effective local anaesthetic for inferior alveolar nerve block?

Irreversible pulpitis: What is the most effective local anaesthetic for inferior alveolar nerve block? Irreversible pulpitis: What is the most effective local anaesthetic for inferior alveolar nerve block? - National Elf Service Search National Elf Service Search National Elf Service » » » » Irreversible pulpitis: What is the most effective local anaesthetic for inferior alveolar nerve block? Mar 1 2019 Posted by Effective local anaesthesia is important in order to undertake root canal (...) treatment. If inadequate this can result in pain, increase fear and anxiety and prolong treatment time. Anaesthesia for mandibular teeth with irreversible pulpitis is usually achieved using inferior alveolar nerve block which has a failure rate estimated to vary between 43-83%. Supplemental techniques such as buccal infiltration, periodontal ligament injection, intra osseous injection and oral premedication have been shown to improve anaesthesia success. However, identifying the most effective

2019 The Dental Elf

6. Personalized Cell Therapy for Pulpitis Using Autologous Dental Pulp Stem Cells and Leukocyte Platelet-rich Fibrin: A Case Report. (PubMed)

Personalized Cell Therapy for Pulpitis Using Autologous Dental Pulp Stem Cells and Leukocyte Platelet-rich Fibrin: A Case Report. Regenerative endodontic procedures have emerged as a new treatment. The aim of this case report was to describe a regenerative autologous cellular therapy using mesenchymal stem cells from inflamed dental pulp and leukocyte platelet-rich fibrin (L-PRF) in a mature tooth.A healthy 50-year-old man consulting for spontaneous dental pain was referred for endodontic (...) treatment in tooth #28, which was diagnosed with symptomatic irreversible pulpitis. Inflamed dental pulp was extracted and transported to a good manufacturing practice laboratory for the isolation and culture of dental pulp stem cells (DPSCs). L-PRF was obtained from the patient's blood and was introduced into the instrumented and disinfected root canal, and expanded DPSCs were inoculated into the clot. The cervical part of the root canal was sealed with Biodentine (Septodont, Saint-Maur-des-Fosses

2019 Journal of Endodontics

7. Does oral Nonsteroidal Anti-inflammatory Drugs (NSAIDs) premedication in patients with irreversible pulpitis increase the success rate of inferior alveolar nerve block? (PubMed)

Does oral Nonsteroidal Anti-inflammatory Drugs (NSAIDs) premedication in patients with irreversible pulpitis increase the success rate of inferior alveolar nerve block? Data sources PubMed, EBSCOhost and Scopus database up till 9 September 2017 in English language. Clinical trial registry and reference lists of published systematic reviews, textbooks and selected articles were also searched.Study selection Population-based randomised clinical trials comparing effects of any single NSAID versus (...) placebo as an oral premedication on the efficacy of IANB in achieving anaesthesia in patients ranging from age 14-68 with irreversible pulpitis who were undergoing nonsurgical root canal therapy in mandibular posterior teeth.Data extraction and synthesis Studies were selected, reviewed and extracted by two independent reviewers using a standardised extraction form. They assessed risk of bias using the revised Cochrane Risk of Bias Tool for Randomised Trials (ROB 2.0). Meta-analysis was performed using

2019 Evidence Based Dentistry

8. Resolvin E1 Ameliorates Pulpitis by Suppressing Dental Pulp Fibroblast Activation in a Chemerin Receptor 23-dependent Manner. (PubMed)

Resolvin E1 Ameliorates Pulpitis by Suppressing Dental Pulp Fibroblast Activation in a Chemerin Receptor 23-dependent Manner. Timely resolution of pulp inflammation is a prerequisite for the healing of inflamed dental pulp. Stromal cells, particularly fibroblasts, play a critical role in the inflammation resolution process. Resolvin E1 (RvE1) is a lipid-derived endogenous proresolution molecule that mediates this resolution process. In the present study, we investigated the effects of RvE1

2019 Journal of Endodontics

9. Efficacy and Safety of Pulpal Anesthesia Strategies during Endodontic Treatment of Permanent Mandibular Molars with Symptomatic Irreversible Pulpitis: A Systematic Review and Network Meta-analysis. (PubMed)

Efficacy and Safety of Pulpal Anesthesia Strategies during Endodontic Treatment of Permanent Mandibular Molars with Symptomatic Irreversible Pulpitis: A Systematic Review and Network Meta-analysis. Several strategies have been investigated for achieving successful pulpal anesthesia during endodontic treatment of mandibular molars with symptomatic irreversible pulpitis. However, comprehensive evaluation and identification of the most efficacious and safe intervention are lacking. We aimed (...) and lingual infiltrations of 4% articaine with 1:100,000 epinephrine are superior strategies to achieve pulpal anesthesia during endodontic treatment of mandibular molars with symptomatic irreversible pulpitis. Preoperative NSAIDs or opioids with or without acetaminophen may increase the efficacy of these injections.Copyright © 2019 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

2019 Journal of Endodontics

10. Anesthetic Efficacy of Gow-Gates, Vazirani-Akinosi, and Mental Incisive Nerve Blocks for Treatment of Symptomatic Irreversible Pulpitis: A Systematic Review and Meta-analysis with Trial Sequential Analysis. (PubMed)

Anesthetic Efficacy of Gow-Gates, Vazirani-Akinosi, and Mental Incisive Nerve Blocks for Treatment of Symptomatic Irreversible Pulpitis: A Systematic Review and Meta-analysis with Trial Sequential Analysis. This systematic review compared the anesthetic efficacy between Gow-Gates (GG), Vazirani-Akinosi (VA), and mental incisive (MI) nerve blocks (NBs) with inferior alveolar nerve blocks (IANBs) in mandibular teeth with irreversible pulpitis using meta-analysis and trial sequential analysis (TSA (...) ).Studies were identified from 4 electronic databases up to June 2019. Randomized clinical trials (RCTs) comparing the anesthetic success rate of GG, VA, and MI NBs with IANBs in mandibular premolars and molars with irreversible pulpitis were included. The quality of selected RCTs was appraised using the revised Cochrane risk of bias tool. Random-effects meta-analyses of risk ratio (RR) and 95% confidence intervals (CIs) were calculated, and random errors were evaluated by TSA. The quality of evidence

2019 Journal of Endodontics

11. Partial pulpotomy with two bioactive cements in permanent teeth of 6- to 18-year-old patients with signs and symptoms indicative of irreversible pulpitis: a noninferiority randomized controlled trial. (PubMed)

Partial pulpotomy with two bioactive cements in permanent teeth of 6- to 18-year-old patients with signs and symptoms indicative of irreversible pulpitis: a noninferiority randomized controlled trial. To compare the outcome of partial pulpotomy using two cements, ProRoot MTA (Dentsply, Tulsa Dental Specialties, Tulsa, OK, USA) and Biodentine (Septodont, Saint-Maur-des-Fossés, France), in permanent teeth of 6- to 18-year-old patients with signs and symptoms indicative of irreversible pulpitis (...) . Furthermore, the frequencies of perceptible grey discoloration caused by the cements were compared.Sixty-nine permanent first molars with signs and symptoms indicative of irreversible pulpitis, from 69 patients, were included. All operators performed partial pulpotomy under a standardized protocol. Teeth were allocated, using a website-generated number of simple randomization, to partial pulpotomy with either ProRoot MTA (37 teeth) or Biodentine (32 teeth) and were restored with composite resin

2019 International endodontic journal Controlled trial quality: predicted high

12. Anesthetic efficacy of mental/incisive nerve block compared to inferior alveolar nerve block using 4% articaine in mandibular premolars with symptomatic irreversible pulpitis: a randomized clinical trial. (PubMed)

Anesthetic efficacy of mental/incisive nerve block compared to inferior alveolar nerve block using 4% articaine in mandibular premolars with symptomatic irreversible pulpitis: a randomized clinical trial. The aim of this study was to compare the onset, success rate, injection pain, and post-injection pain of mental/incisive nerve block (MINB) with that of inferior alveolar nerve block (IANB) using 4% articaine in mandibular premolars with symptomatic irreversible pulpitis. The accuracy (...) mandibular premolars with irreversible pulpitis. Post-injection pain with MINB was higher than with IANB.MINB and IANB with 4% articaine can be used interchangeably to anesthetize mandibular premolars with irreversible pulpitis.

2019 Clinical oral investigations Controlled trial quality: uncertain

13. The Effect of Cryotherapy Application on the Success Rate of Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis. (PubMed)

The Effect of Cryotherapy Application on the Success Rate of Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis. This randomized clinical trial assessed the effect of preoperative intraoral cryotherapy application on the success rate of inferior alveolar nerve blocks (IANBs) in patients with symptomatic irreversible pulpitis (SIP).One hundred four patients with SIP were randomly distributed into 2 groups: control and cryotherapy groups. In the control group

2019 Journal of Endodontics Controlled trial quality: uncertain

14. The Effect of Submucosal Injection of Corticosteroids on Pain Perception and Quality of Life after Root Canal Treatment of Teeth with Irreversible Pulpitis: A Randomized Clinical Trial. (PubMed)

The Effect of Submucosal Injection of Corticosteroids on Pain Perception and Quality of Life after Root Canal Treatment of Teeth with Irreversible Pulpitis: A Randomized Clinical Trial. The aim of the present investigation was to study the effect of local infiltration of corticosteroids on postoperative pain and quality of life (QOL) in teeth with irreversible pulpitis after 1-visit endodontic treatment.In this double-blind randomized clinical trial, 242 healthy patients with irreversible (...) pulpitis undergoing 1-visit endodontic treatment were included. Forty-five patients were lost during the follow-up, and the remaining 197 patients were followed for 7 days (67 patients in the placebo group, 66 in the long-acting betamethasone group, and 64 in the dexamethasone group). The patients marked their level of pain and QOL before treatment and at 6-, 12-, 24-, 48-, and 72-hour and 7-day postoperative intervals using a questionnaire. Freidman and Kruskal-Wallis tests were used for statistical

2019 Journal of Endodontics Controlled trial quality: uncertain

15. Evaluation of postoperative pain intensity following occlusal reduction in teeth associated with symptomatic irreversible pulpitis and symptomatic apical periodontitis: a randomized clinical study. (PubMed)

Evaluation of postoperative pain intensity following occlusal reduction in teeth associated with symptomatic irreversible pulpitis and symptomatic apical periodontitis: a randomized clinical study. To assess the effect of occlusal reduction on postoperative pain following two visits root canal treatment in posterior mandibular teeth with symptomatic irreversible pulpitis and symptomatic apical periodontitis in a randomized clinical trial.This trial was conducted in the outpatient clinic (...) of the Endodontic Department of the Faculty of Oral and Dental Medicine, Cairo University in Egypt. Forty-four-patients diagnosed with symptomatic irreversible pulpitis and symptomatic apical periodontitis were randomly assigned into two equal groups. The occlusal surfaces of teeth in the intervention group were reduced; whilst those assigned to the control group were left intact. Canal instrumentation was completed in the first visit using Revo-S rotary nickel-titanium files, and pain intensity was assessed

2019 International endodontic journal Controlled trial quality: uncertain

16. Antibiotic use for irreversible pulpitis. (PubMed)

Antibiotic use for irreversible pulpitis. Irreversible pulpitis, which is characterised by acute and intense pain, is one of the most frequent reasons that patients attend for emergency dental care. Apart from removal of the tooth, the customary way of relieving the pain of irreversible pulpitis is by drilling into the tooth, removing the inflamed pulp (nerve) and cleaning the root canal. However, a significant number of dentists continue to prescribe antibiotics to stop the pain (...) trial assessed as a low risk of bias, illustrates that there is insufficient evidence to determine whether antibiotics reduce pain or not compared to not having antibiotics. The results of this review confirm the necessity for further larger sample and methodologically sound trials that can provide additional evidence as to whether antibiotics, prescribed in the preoperative phase, can affect treatment outcomes for irreversible pulpitis.

Full Text available with Trip Pro

2013 Cochrane

17. Buffered Lidocaine Does Not Improve the Inferior Alveolar Block Success For Mandibular Posterior Teeth With Symptomatic Irreversible Pulpitis

Buffered Lidocaine Does Not Improve the Inferior Alveolar Block Success For Mandibular Posterior Teeth With Symptomatic Irreversible Pulpitis UTCAT2946, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Buffered Lidocaine Does Not Improve the Inferior Alveolar Block Success For Mandibular Posterior Teeth With Symptomatic Irreversible Pulpitis Clinical Question For patients with symptomatic irreversible pulpitis (...) , is Lidocaine buffered with Sodium Bicarbonate a more successful anesthetic compared to conventional non-buffered Lidocaine when administered as an inferior alveolar nerve block? Clinical Bottom Line Buffered Lidocaine for inferior alveolar nerve (IAN) block does not result in statistically significant increased success rate of IAN block or decrease in injection pain on mandibular posterior teeth with symptomatic irreversible pulpitis. Best Evidence (you may view more info by clicking on the PubMed ID link

2015 UTHSCSA Dental School CAT Library

18. Preemptive Nonsteroidal Anti-Inflammatory Drugs May Increase the Success Rate of Inferior Alveolar Nerve Blocks in Mandibular Posterior Teeth with Symptomatic Irreversible Pulpitis

Preemptive Nonsteroidal Anti-Inflammatory Drugs May Increase the Success Rate of Inferior Alveolar Nerve Blocks in Mandibular Posterior Teeth with Symptomatic Irreversible Pulpitis UTCAT2807, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Preemptive Nonsteroidal Anti-Inflammatory Drugs May Increase the Success Rate of Inferior Alveolar Nerve Blocks in Mandibular Posterior Teeth with Symptomatic Irreversible Pulpitis (...) Clinical Question In mandibular posterior teeth with symptomatic irreversible pulpitis, does a preemptive dose of an oral nonsteroidal anti-inflammatory drug (NSAID) increase the success rate of an inferior alveolar nerve block (IANB) compared to placebo? Clinical Bottom Line For patients with irreversible pulpitis in a mandibular posterior tooth, a single preemptive dose of NSAID may increase the success of IANB compared to placebo. This is supported by a meta-analysis of seven clinical trials

2015 UTHSCSA Dental School CAT Library

19. Articaine (4%) Does Not Improve Inferior Alveolar Nerve Block Success Compared to Lidocaine (2%) for Mandibular Molars with Irreversible Pulpitis

Articaine (4%) Does Not Improve Inferior Alveolar Nerve Block Success Compared to Lidocaine (2%) for Mandibular Molars with Irreversible Pulpitis UTCAT2658, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Articaine (4%) Does Not Improve Inferior Alveolar Nerve Block Success Compared to Lidocaine (2%) for Mandibular Molars with Irreversible Pulpitis Clinical Question For patients with irreversible pulpitis in mandibular (...) molars, is 4% articaine superior to 2% lidocaine in achieving successful anesthesia when administered as an inferior alveolar nerve block? Clinical Bottom Line Administration of 4% articaine as an inferior alveolar nerve (IAN) block does not result in greater anesthesia success compared to 2% lidocaine when providing endodontic treatment to mandibular molars diagnosed with irreversible pulpitis. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient

2014 UTHSCSA Dental School CAT Library

20. Supplemental Intraosseous Anesthesia Improves the Success Rate of Inferior Alveolar Nerve Blocks in Molars with Irreversible Pulpitis.

Supplemental Intraosseous Anesthesia Improves the Success Rate of Inferior Alveolar Nerve Blocks in Molars with Irreversible Pulpitis. UTCAT2689, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Supplemental Intraosseous Anesthesia Improves the Success Rate of Inferior Alveolar Nerve Blocks in Molars with Irreversible Pulpitis. Clinical Question In patients receiving treatment for irreversible pulpitis of mandibular (...) molars, does the supplemental intraosseous anesthesia provide a superior clinical success rate compared to an inferior alveolar nerve block alone? Clinical Bottom Line In cases with patients being treated for irreversible pulpitis, a supplemental delivery of local anesthetic by means of intraosseous injection following an initial inferior alveolar nerve block aids in achieving successful pain free treatment. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author

2014 UTHSCSA Dental School CAT Library

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