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Pulmonary Hypertension in Sickle Cell Anemia


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381. Exercise For Sub-acute Stroke Patients in Jamaica

) restricting exercise, c) pulmonary or renal failure, d) active cancer, e) untreated poorly controlled hypertension measured on at least 2 occasions (greater than 160/100), f) HIV-AIDS or other known inflammatory responses, g) sickle cell anemia, h) medications: heparin, warfarin, lovenox, or oral steroids, j) currently pregnant Endocrine History: a) type 1 diabetes or insulin dependent type 2 diabetes, b) poorly controlled type 2 diabetes (HbA1C > 10) Neurological History: a) dementia (Mini-Mental Status

2011 Clinical Trials

382. Management of Pregnancy

Placental abruption v Prior cesarean section v Intrapartum complications v GYNECOLOGIC, MEDICAL, SURGICAL CONDITIONS Current need for surgery v Bariatric surgery ( 36 months ago) v Diabetes mellitus (DM) – Type 1 or 2 v Hematalogic disorders (except mild anemia) v Gastrointestinal disorders on medication v Chronic hypertension v Cardiovascular disease v Pulmonary disease including asthma v Cancer (current or recent) v Neurological disorders including epilepsy v VA/DoD Clinical Practice Guideline (...) /bariatric surgery (see I-28) - Mild depression (I- 21 & 34) - Cardiovascular disease - High blood pressure - Familial hyperlipidemia - Pregestational diabetes - Kidney disease (including pyelonephritis) - Inflammatory bowel disease - Bronchio pulmonary disease including asthma - Autoimmune diseases including Anticardiolipin Antibody Syndrome, and Systemic Lupus Erythematosis - Thromboembolic disease, current or historical - Cancer - Seizure disorders - Hematologic disorders (including anemia

2009 VA/DoD Clinical Practice Guidelines

383. Overview of High-Risk Pregnancy

injury 10 Neonatal death 5 Cesarean delivery 5 Habitual ( ≥ 3) abortion 5 Neonate > 4.5 kg 5 Shoulder dystocia 5 Multiparity of > 5 5 Seizure disorders or cerebral palsy 5 Fetal malformations 1 Other disorders Abnormal cervical cytologic findings 10 Sickle cell disease 10 Thrombophilia 10 Autoimmune disorders 10 Positive serologic results for STDs 5 Severe anemia (Hb 9 g/dL) 5 History of TB or purified protein derivative injection site induration ≥ 10 mm 5 Pulmonary disorders 5 Mild anemia (Hb 9.0 (...) WHO, UNICEF, UNFPA, The World Bank, and the United Nations Population Division. Trends in Maternal Mortality: 1990 to 2015. Geneva, World Health Organization, 2015. The most common causes of maternal death worldwide are Hemorrhage Preeclampsia Sepsis Abortion (including induced abortion, miscarriage, and ectopic pregnancy) Pulmonary embolism Obstetric complications Other disorders (eg, preexisting disorders such as HIV infection [ ]) Nearly half of maternal deaths are preventable. Perinatal

2013 Merck Manual (19th Edition)

384. Ischemic Stroke

contraceptive formulations increase risk of thrombosis. In children, sickle cell disease is a common cause of ischemic stroke. Embolism Emboli may lodge anywhere in the cerebral arterial tree. Emboli may originate as cardiac thrombi, especially in the following conditions: Atrial fibrillation Rheumatic heart disease (usually mitral stenosis) Post-MI Vegetations on heart valves in bacterial or marantic endocarditis Prosthetic heart valves Mechanical circulatory assist devices (eg, left ventricular assist (...) in elderly patients with diabetes or poorly controlled hypertension. Other causes Any factor that impairs systemic perfusion (eg, carbon monoxide toxicity, severe anemia or hypoxia, polycythemia, hypotension) increases risk of all types of ischemic strokes. A stroke may occur along the borders between territories of arteries (watershed areas); in such areas, blood supply is normally low, particularly if patients have hypotension and/or if major cerebral arteries are stenotic. Less commonly, ischemic

2013 Merck Manual (19th Edition)

385. Air Travel

, asthma, COPD, cystic fibrosis), heart failure, anemia with Hb < 8.5 g/dL, severe angina pectoris, sickle cell disease (but not trait), and some congenital heart diseases. When flying is essential, such patients can usually fly safely with specially designed continuous oxygen equipment, which must be provided by the airline. Mild ankle edema due to venous stasis commonly develops during long flights and should not be confused with heart failure. Smoking can aggravate mild hypoxia and should be avoided (...) of the following illicit drugs is most likely to cause intractable seizures, tachycardia, hypertension, and hyperthermia when a drug packet with the drug used in body packing ruptures? Anabolic steroids Cocaine Heroin Marijuana NEWS & VIDEOS History of Cycling Weight May Up Risk for Heart Disease in Women FRIDAY, March 8, 2019 (HealthDay News) -- A history of weight cycling (HWC), or yo-yo dieting, is associated with poorer cardiovascular health in women, according to a study presented at the... SOCIAL MEDIA

2013 Merck Manual (19th Edition)

386. Pilot Study Evaluating the Safety and Performance of the GeNO NITROsyl Delivery System for Inhaled Nitric Oxide

the last six months CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) syndrome Have a history of uncontrolled sleep apnea within three months of RHC. Have a history of hemodynamically significant left-sided heart disease Have evidence of left-sided heart disease Have any other disease that is associated with pulmonary hypertension (e.g. congenital systemic-to-pulmonary shunt, sickle cell anemia, schistosomiasis). Documented uncontrolled systemic hypertension (...) , 2010 Results First Posted : June 4, 2013 Last Update Posted : June 4, 2013 Sponsor: Geno LLC Information provided by (Responsible Party): Geno LLC Study Details Study Description Go to Brief Summary: This is an open label phase 2 pilot study designed to evaluate the safety, tolerability and device performance of the GeNO nitrosyl delivery system during right heart catheterization (RHC) in participants with pulmonary arterial hypertension (PAH). All participants will receive inhaled nitric oxide

2010 Clinical Trials

387. A Prospective Study Measuring Exhaled Nitric Oxide in Exercise-Induced Asthma

rejection, pulmonary sarcoidosis, chronic cough (i.e. greater four weeks), systemic sclerosis, hypersensitivity, cystic fibrosis, HIV, sickle cell anemia, cardiac pulmonary bypass, liver cirrhosis, alpha-1 anti-trypsin disease and interstitial lung Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its (...) , rhinitis, bronchiectasis, active pulmonary sarcoidosis, active fibrosing alveolitis, and acute lung allograft rejection. Decreased FeNO levels have been seen in patients with primary ciliary dyskinesia, cystic fibrosis, PiZZ phenotype-related alpha-1 antitrypsin deficiency, and pulmonary hypertension Two studies have addressed the variations on FeNO after EIB and they had contradictory results. Scollo et al. found no change in FeNO in either healthy or asthmatic children after a 6-min of vigorous

2010 Clinical Trials

388. Exhaled Nitric Oxide Levels in Infants and Young Children Infected With RSV or Other Viral Infections

significant respiratory viral infection; all patients with underlying diagnosis of asthma/RAD, recurrent wheezing, "recurrent bronchiolitis", allergic rhinitis, atopy, any chronic lung disease, hypertension, heart failure, kidney failure receiving or not dialysis, pulmonary hypertension, primary ciliary dyskinesia, bronchiectasis, alveolitis, lung transplant rejection, pulmonary sarcoidosis, chronic cough (i.e. greater four weeks), systemic sclerosis, hypersensitivity, cystic fibrosis, HIV, sickle cell (...) pulmonary disease (COPD), cystic fibrosis (CF). Although, some exquisite bench research experiments have demonstrated stimulation of nitric oxide production in respiratory epithelial cells infected with RSV, there is a paucity of clinical data regarding levels of feNO in viral respiratory illness and specifically RSV. The investigators conducted a pilot study from the fall of 2007 until October of 2009, looking at FeNO levels in RSV infected patients and compared it to non-RSV viral infections

2010 Clinical Trials

389. Magnesium in Crisis

(avascular necrosis, gall bladder disease, priapism, etc.) patient with greater than 10 admissions for pain crisis in the past year patient maintained on daily opioids or chronic transfusions for chronic sickle cell pain transfusion within the previous two months known kidney or liver failure (elevation of liver function tests does not warrant exclusion) known pulmonary hypertension pregnancy diagnosis of bacterial infection, fever ≥39.5°C, acute chest syndrome, hemodynamic instability or sepsis current (...) personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 4 Years to 21 Years (Child, Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: age 4-21 years, inclusive Sickle cell anemia (Hb SS) or Sickle

2010 Clinical Trials

390. Revatio for Heart Disease in Duchenne Muscular Dystrophy and Becker Muscular Dystrophy

such as retinitis pigmentosa History of priapism or conditions that may predispose to priapism such as sickle cell anemia, multiple myeloma, or leukemia Bleeding disorders Active tobacco use Chronic atrial fibrillation or frequent arrhythmia that would result in an irregular pulse Factors that would preclude obtaining an MRI study - (e.g. implantable pacemaker or cardioverter-defibrillator; body habitus cannot fit into scanner) Systolic blood pressure (SBP) less than 85 mmHg at baseline evaluation Chronic (...) and improved vascular tone in animal models of heart failure. This will be a phase 2, randomized, double-blind, placebo-controlled single center study for 6 months followed by open-label period of 6 months in which all enrolled subjects receive Revatio (a PDE5 inhibitor). A single dose of Revatio (20 mg three times daily) will be tested based on the safety and efficacy of that dose for treatment of pulmonary hypertension. The primary endpoint will be the change in cardiac left ventricular end-systolic

2010 Clinical Trials

391. Adaptive Support Ventilation in Acute Respiratory Distress Syndrome (ARDS)

of left atrial hypertension Exclusion criteria: Age less than 12 years Patients having underlying chronic lung disease (COPD, interstitial lung disease, pulmonary hypertension) Contraindication to permissive hypercapnea (raised intracranial pressure, acute cerebrovascular disorders, acute or chronic myocardial ischemia, right ventricular failure, uncorrected severe metabolic acidosis, sickle cell anemia, tricyclic antidepressant overdose, pregnancy) Study Design Go to Layout table for study (...) failure, uncorrected severe metabolic acidosis, sickle cell anemia, tricyclic antidepressant overdose, pregnancy) Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT number): NCT01165528 Locations Layout table for location information India Respiratory intensive care

2010 Clinical Trials

392. Baclofen and Hypoxia-induced Periodic Ventilation

of psychiatric disorder Any respiratory disease (including asthma) Leg arteriopathy Sickle cell anemia Renal insufficiency Migraine Diabetes Obesity Thalassemia Scoliosis Past history of phlebitis Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT number): NCT01095679 (...) treatment except first grade antalgic drugs (e. g. ACETAMINOFEN) Written consent to participate in the study Health insurance Exclusion Criteria: Intolerance to baclofen Tobacco, alcohol or drug consumption Past history of possible acute mountain sickness Regular treatment for any disease Claustrophobia Coronary disease Hypertension Cardiac failure Cardiac rhythm abnormalities Pulmonary hypertension Any pulmonary artery abnormality Any cardiac disease Past history of cerebral ischemia Past history

2010 Clinical Trials

393. Exhaled Nitric Oxide in Respiratory Syncytial Virus (RSV) Bronchiolitis: a Pilot Study

cough (i.e. greater four weeks) systemic sclerosis hypersensitivity cystic fibrosis HIV sickle cell anemia cardiac pulmonary bypass liver cirrhosis alpha-1 anti-trypsin disease interstitial lung Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT number (...) tract viral illness (LRTVI) will be offered the opportunity to participate Criteria Inclusion Criteria: Admitted subjects with diagnosis of bronchiolitis, viral pneumonia or other significant respiratory viral infection Exclusion Criteria: asthma/RAD recurrent wheezing "recurrent bronchiolitis" allergic rhinitis atopy chronic lung disease hypertension heart failure pulmonary hypertension primary ciliary dyskinesia bronchiectasis alveolitis lung transplant rejection pulmonary sarcoidosis chronic

2009 Clinical Trials

394. Long Term Effects of Erythrocyte Lysis

: In this prospective observational trial, participants with chronic hemolysis will be assessed with echocardiogram for elevated tricuspid jet velocity and other evidence of pulmonary hypertension. Participants will have laboratory studies evaluating: severity of hemolysis, splenic function, inflammation, endothelial dysfunction, and hypercoagulability. There will be 3 main categories of participants enrolled in this study: (1) pediatric participants with severe sickle cell disease (SCD) (HbSS, HbS/β° thalassemia (...) ) who are not receiving treatment (e.g., hydroxyurea or chronic transfusions); (2) pediatric participants with other forms of SCD or severe SCD (HbSS, HbS/β° thalassemia) patients being treated with hydroxyurea or chronic transfusions; and (3) pediatric and adult participants with other non-sickling hematological disorders. Condition or disease Intervention/treatment Sickle Cell Disease Hemolytic Anemia Procedure: Clinical Evaluations Other: Laboratory Studies Detailed Description: The study

2009 Clinical Trials

395. Omega-3 Supplementation Decreases Inflammation and Fetal Obesity in Pregnancy

disease (acute hepatitis, chronic active hepatitis, persistently abnormal liver enzymes). Platelet or red blood cell disorder (including idiopathic thrombocytopenia purpura, a history of alloimmune thrombocytopenia in a previous offspring, significant anemia due to hemoglobinopathy but not sickle cell trait. Iron deficiency anemia will NOT be an exclusion as long as the hemoglobin is > 8 gm/dl). Chronic pulmonary disease (asthma of any degree of severity is NOT an exclusion). Structural, functional (...) this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 40 Years (Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: BMI (wt/ht2) > or = 25 at first antenatal visit Gestational age at randomization between 8-16 weeks No medical problems such as hyperlipidemia, hypertension, or pregestational diabetes Between

2009 Clinical Trials

396. Phase 2B Dose Ranging Study of Locteron Plus Ribavirin to Treat HCV

of HCC Uncontrolled diabetes mellitus as evidenced by HbA1C ≥ 8.5% at screening Known hypersensitivity to interferon alfa or ribavirin Chronic liver disease other than HCV not limited to HBV, hemochromatosis, auto-immune hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease) Clinically significant hemoglobinopathy such as thalassemia major and sickle cell anemia History of moderate, severe or uncontrolled psychiatric disease including depression and prior suicide attempts History (...) of immune-mediated disease Significant renal or neurological disease Severe degree (> GOLD stage III) of chronic pulmonary disease (COPD) or active, severe asthma Subjects with severe cardiac disease (e.g., heart failure, recent [i.e., within 6 months prior to first dosing] myocardial infarction, angina, serious arrhythmias, including prolonged QTc [> 450 mSec], uncontrolled hypertension) History of significant central nervous system (including CNS trauma) or seizure disorders Cancer within the last 5

2009 Clinical Trials

397. L-Arginine

episodes of MELAS associated with the G13513A mutation. Brain Dev. 2011;33:518-520. . Sullivan, K. J., Kissoon, N., Sandler, E., Gauger, C., Froyen, M., Duckworth, L., Brown, M., and Murphy, S. Effect of oral arginine supplementation on exhaled nitric oxide concentration in sickle cell anemia and acute chest syndrome. J Pediatr Hematol.Oncol. 2010;32:e249-e258. . Bailey, S. J., Winyard, P. G., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., and Jones, A. M. Acute L-arginine (...) dysfunction (ED), altitude sickness, nitrate tolerance, diabetes, diabetic nerve pain, muscular dystrophy, kidney toxicity from cyclosporine, valproic acid toxicity, anthracycline toxicity, kidney disease, tuberculosis, critical illness, head and neck cancer, obesity, ovary disease (polycystic ovary syndrome), pressure ulcers, respiratory infections, sickle cell disease, stress, and male infertility. Some people use L-arginine for preventing the common cold, improving kidney function after a kidney

2009 National Centre for Complementary and Alternative Medicine

398. Niacin and Niacinamide (Vitamin B3)

on lipoprotein sub-particle concentrations in HIV-infected patients. Hawaii J Med Public Health. 2013 Apr;72:123-7. . Scoffone HM, Krajewski M, Zorca S, et al. Effect of extended-release niacin on serum lipids and on endothelial function in adults with sickle cell anemia and low high-density lipoprotein cholesterol levels. Am J Cardiol. 2013 Nov 1;112:1499-504. . 96208 Brunner G, Yang EY, Kumar A, et al. The effect of lipid modification on peripheral artery disease after endovascular intervention trial (...) not lower blood phosphate levels when taken along with medication used to lower blood phosphate levels. Blockage of the vein in the eye (retinal vein occlusion) : Early research shows that taking niacin might improve eyesight in people with a blockage in the retinal vein. Sickle cell disease : Early research shows that taking niacin does not improve the levels of blood fats in people with sickle cell disease. Acne . Alcohol dependence . Attention deficit-hyperactivity disorder (ADHD) . Depression

2009 National Centre for Complementary and Alternative Medicine

399. Inhibition of Disease Progression in Hepatitis C-infected Patients With Compensated Liver Cirrhosis (P03811) (COMPLETED)

thrombocytopenic purpura, systemic lupus erythematosus, autoimmune hemolytic anemia, scleroderma, etc). Patients with Hemoglobinopathies (thalassaemia, sickle cell anemia) Patients with malignant tumors Patients with organ transplants (other than cornea and hair transplant). Patients with a history of hypersensitivity to interferon preparations, biological products such as vaccine, or nucleoside analogs Female patients who are pregnant or nursing (male patients with partner who are pregnant), and for whom (...) disorder such as depression. Patients with or who have a history of epileptic seizures requiring treatment Patients with or who have a history of angina pectoris, heart failure, myocardial infarction, uncontrollable hypertension (diastolic blood pressure: equal to or more than 110mmHg) or arrhythmia which needs treatment. Patients with chronic pulmonary disease Patients with or who have a history of autoimmune disease (Crohn's disease, ulcerative colitis, chronic rheumatoid arthritis, idiopathic

2008 Clinical Trials

400. Relative Bioavailability of Iron and Folic Acid in New Test Supplement

colitis A history of or current use of IV iron therapy or erythropoietin therapy A history or presence of any clinically significant gastrointestinal pathology (eg. chronic diarrhea, inflammatory bowel disease, partial gastrectomy), unresolved gastrointestinal symptoms (eg. diarrhea or vomiting), steatorrhea, or other conditions known to interfere with the absorption, distribution, metabolism or excretion of iron or folic acid Abnormal hemoglobin electrophoresis ie. sickle cell anemia, thalassemia (...) Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Healthy pregnant women between 18 and 45 years of age in the second or third trimester of pregnancy (24-32 weeks of gestational age). Normal Hb (Hb≥110g/L and Hb≤144g/L) Exclusion Criteria: Chronic illness (clinically significant neurological, endocrine, cardiovascular, pulmonary, hematologic, immunologic, psychiatric or metabolic diseases) A history or presence of hemosiderosis, hemochromatosis, peptic ulcer, regional enteritis, ulcerative

2008 Clinical Trials

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