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Ptosis

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2401. Ptosis as the early manifestation of pituitary tumour. Full Text available with Trip Pro

Ptosis as the early manifestation of pituitary tumour. Three patients who developed unilateral ptosis followed by partial third nerve palsy were found to have a pituitary tumour. The visual field defects were minimal and asymptomatic. Two patients had a chromophobe adenoma and one patient had a prolactinoma. The importance of recognising a pituitary tumour as the cause of acquired unilateral ptosis is emphasised.

1990 The British journal of ophthalmology

2402. Linear scleroderma associated with ptosis and motility disorders. Full Text available with Trip Pro

Linear scleroderma associated with ptosis and motility disorders. A case is reported in which an 11-year-old girl developed progressive ptosis and a subsequent motility disorder of the right eye. The diagnosis linear scleroderma en coup de sabre was established. Atrophy of the upper levator palpebral and superior rectus muscle could be shown on CT scan.

1990 The British journal of ophthalmology

2403. Linkage analysis in blepharophimosis-ptosis syndrome confirms localisation to 3q21-24 Full Text available with Trip Pro

Linkage analysis in blepharophimosis-ptosis syndrome confirms localisation to 3q21-24 8558553 1996 02 28 2018 11 13 0022-2593 32 10 1995 Oct Journal of medical genetics J. Med. Genet. Linkage analysis in blepharophimosis-ptosis syndrome confirms localisation to 3q21-24. 774-7 Harrar H S HS Medical Genetics Unit, St George's Hospital Medical School, London, UK. Jeffery S S Patton M A MA eng Journal Article England J Med Genet 2985087R 0022-2593 IM Adult Blepharophimosis genetics Blepharoptosis

1995 Journal of Medical Genetics

2404. A gene for isolated congenital ptosis maps to a 3-cM region within 1p32-p34.1. Full Text available with Trip Pro

A gene for isolated congenital ptosis maps to a 3-cM region within 1p32-p34.1. Hereditary isolated congenital ptosis is an autosomal dominant disorder with incomplete penetrance characterized by a variable degree of unilateral or bilateral drooping of the upper eyelids. We report linkage of this disorder in a large family to markers on chromosome 1p. In our sample of 37 meioses, nine informative markers did not recombine with the disease. D1S2677 gave a maximum two-point LOD score of 8.8 (...) on the assumption of 90% penetrance (theta = 0). D1S447/2733 and D1S1616 flank the disease locus, with two-point LOD scores of 5.6/6.6 (theta = .04) and 4.9 (theta = .05), respectively, defining a region of 2.8 cM. FISH of YACs containing flanking recombinant markers localizes the gene to chromosome 1p32-p34.1. These data establish a map location for an isolated congenital ptosis gene and demonstrate that this disorder is genetically distinct from other extraocular muscle-specific disorders such as congenital

1997 American Journal of Human Genetics

2405. A Novel X-Linked Dominant Condition: X-Linked Congenital Isolated Ptosis Full Text available with Trip Pro

A Novel X-Linked Dominant Condition: X-Linked Congenital Isolated Ptosis We present a large family with a previously undescribed condition: X-linked dominant congenital bilateral isolated ptosis. Linkage analysis defined a critical region between Xq24 and Xq27.1, with a maximum single-point LOD score of 2.88 at DXS1047 and DXS984. Male and female family members are equally affected, providing an example of an X-linked, truly dominant condition.

2000 American Journal of Human Genetics

2406. Intermittent ptosis due to large exophoria Full Text available with Trip Pro

Intermittent ptosis due to large exophoria 10610109 1999 12 17 2008 11 20 0007-1161 83 11 1999 Nov The British journal of ophthalmology Br J Ophthalmol Intermittent ptosis due to large exophoria. 1308-9 Langerhorst C T CT Wenniger-Prick L L eng Case Reports Letter England Br J Ophthalmol 0421041 0007-1161 IM Aged Blepharoptosis etiology Exotropia complications Humans Male 1999 12 28 1999 12 28 0 1 1999 12 28 0 0 ppublish 10610109 PMC1722866

1999 The British journal of ophthalmology

2407. Complications of fascia lata harvesting for ptosis surgery Full Text available with Trip Pro

Complications of fascia lata harvesting for ptosis surgery 9602644 1998 06 02 2008 11 20 0007-1161 82 3 1998 Mar The British journal of ophthalmology Br J Ophthalmol Complications of fascia lata harvesting for ptosis surgery. 333-4 Naugle T C TC Jr eng Comment Letter England Br J Ophthalmol 0421041 0007-1161 IM Br J Ophthalmol. 1997 Jul;81(7):581-3 9290374 Blepharoptosis surgery Cicatrix etiology Esthetics Fascia Lata transplantation Humans Postoperative Complications 1998 5 29 2 3 2001 3 28 10

1998 The British journal of ophthalmology

2408. Mechanical ptosis and lagophthalmos in cutaneous leishmaniasis Full Text available with Trip Pro

Mechanical ptosis and lagophthalmos in cutaneous leishmaniasis 9828788 1998 12 01 2008 11 20 0007-1161 82 8 1998 Aug The British journal of ophthalmology Br J Ophthalmol Mechanical ptosis and lagophthalmos in cutaneous leishmaniasis. 975 Satici A A Gurler B B Gurel M S MS Aslan G G Oguz H H eng Case Reports Letter England Br J Ophthalmol 0421041 0007-1161 IM Adolescent Blepharoptosis parasitology Eye Infections, Parasitic Eyelid Diseases parasitology Humans Leishmaniasis, Cutaneous

1998 The British journal of ophthalmology

2409. Pharmacological reversal of ptosis in a patient with acquired Horner's syndrome and heterochromia Full Text available with Trip Pro

Pharmacological reversal of ptosis in a patient with acquired Horner's syndrome and heterochromia 9893610 1999 01 25 2013 11 21 0007-1161 82 9 1998 Sep The British journal of ophthalmology Br J Ophthalmol Pharmacological reversal of ptosis in a patient with acquired Horner's syndrome and heterochromia. 1095 Parsa C F CF George N D ND Hoyt C S CS George N D ND eng Case Reports Letter England Br J Ophthalmol 0421041 0007-1161 0 Sympathomimetics 1WS297W6MV Phenylephrine IM Blepharoptosis drug

1998 The British journal of ophthalmology

2410. Unilateral ptosis due to isolated involvement of the levator muscle in acute orbital myositis Full Text available with Trip Pro

Unilateral ptosis due to isolated involvement of the levator muscle in acute orbital myositis 10917686 2000 07 27 2008 11 20 0007-1161 83 5 1999 May The British journal of ophthalmology Br J Ophthalmol Unilateral ptosis due to isolated involvement of the levator muscle in acute orbital myositis. 631-2 Wheatcroft S S Elston J J eng Case Reports Letter England Br J Ophthalmol 0421041 0007-1161 IM Blepharoptosis etiology Female Humans Middle Aged Myositis complications Orbital Diseases

1999 The British journal of ophthalmology

2411. Rapid onset of ptosis indicates accurate intraconal placement during retrobulbar anaesthetic injection Full Text available with Trip Pro

Rapid onset of ptosis indicates accurate intraconal placement during retrobulbar anaesthetic injection Anecdotal evidence has previously suggested that retrobulbar local anaesthetic (LA) injection is accompanied by the rapid onset of ptosis. Here the validity of this potentially valuable sign is tested.25 patients received a retrobulbar injection and the times for development of ptosis and akinesia in other extraocular muscle groups were recorded and compared. The effects of retrobulbar (...) injections were also studied on posterior orbital structures in 10 patients using low frequency ultrasound.The mean time of onset of ptosis was 4.76 seconds, an order of magnitude less than times recorded for akinesia in other muscle groups. Ultrasonography revealed a significant distension of the extraocular muscle cone during retrobulbar injection.Ptosis develops significantly more rapidly than other motor effects in retrobulbar anaesthesia and can therefore be taken as an indicator of accurate

2001 The British journal of ophthalmology

2412. Diplopia, ptosis, and hepatitis as presenting signs and symptoms of giant cell arteritis Full Text available with Trip Pro

Diplopia, ptosis, and hepatitis as presenting signs and symptoms of giant cell arteritis 11203169 2000 12 05 2008 11 20 0007-1161 84 11 2000 Nov The British journal of ophthalmology Br J Ophthalmol Diplopia, ptosis, and hepatitis as presenting signs and symptoms of giant cell arteritis. 1319-20 Killer H E HE Holtz D J DJ Kaiser H J HJ Laeng R H RH eng Case Reports Letter England Br J Ophthalmol 0421041 0007-1161 IM Aged Biopsy Blepharoptosis etiology Diplopia etiology Female Giant Cell

2000 The British journal of ophthalmology

2413. X linked dominant congenital isolated bilateral ptosis: the definition and characterisation of a new condition Full Text available with Trip Pro

X linked dominant congenital isolated bilateral ptosis: the definition and characterisation of a new condition To characterise the inheritance of ptosis in one particular pedigree.The pedigree was analysed clinically and genetically to assess the mode of inheritance and to ascribe a gene locus for the condition.Affected members of the pedigree have bilateral symmetrical congenital isolated ptosis, a condition which is linked to genetic markers on the X chromosome in this family.A pedigree (...) with dominantly inherited congenital bilateral ptosis is presented. The pedigree exhibits X linked dominant inheritance. A new ophthalmic condition was thereby characterised-namely, X linked dominant congenital isolated bilateral ptosis.

2001 The British journal of ophthalmology

2414. Novel autosomal dominant mandibulofacial dysostosis with ptosis: clinical description and exclusion of TCOF1 Full Text available with Trip Pro

Novel autosomal dominant mandibulofacial dysostosis with ptosis: clinical description and exclusion of TCOF1 Treacher Collins syndrome (TCS), the most common type of mandibulofacial dysostosis (MFD), is genetically homogeneous. Other types of MFD are less common and, of these, only the Bauru type of MFD has an autosomal dominant (AD) mode of inheritance established. Here we report clinical features of a kindred with a unique AD MFD with the exclusion of linkage to the TCS locus (TCOF1 (...) features included hypoplasia of the zygomatic complex, micrognathia with malocclusion, auricular abnormalities with conductive hearing loss, and ptosis. Significantly negative two point lod scores were obtained for markers spanning the TCOF1 locus, excluding the possibility that the disease in our kindred is allelic with TCS. High resolution karyotype was normal.We report a kindred with a novel type of MFD that is not linked to the TCOF1 locus and is also clinically distinct from other types of AD MFD

2002 Journal of Medical Genetics

2415. Postcataract ptosis. A randomized, double-masked comparison of peribulbar and retrobulbar anesthesia. (Abstract)

Postcataract ptosis. A randomized, double-masked comparison of peribulbar and retrobulbar anesthesia. A randomized, double-masked study of 317 patients was conducted to determine if the incidence of postcataract ptosis is greater with retrobulbar or two-injection peribulbar injection anesthesia.Surgery consisted of a planned extracapsular extraction with posterior chamber lens implantation, and no superior rectus bridle suture was used. Ptosis was quantitatively documented preoperatively (...) and postoperatively at 1, 2, 5, and 90 days by the surgeon, photographically at 90 days by a masked observer, and subjectively by the patients. Postcataract ptosis was defined as a drop in the lid margin of 2 mm or greater after correcting for any change in the fellow eye.The incidence of ptosis at 90 days in patients given peribulbar anesthesia was 5.8% and in patients given retrobulbar anesthesia 5.5%, and this difference was not statistically significant (P = 0.90). Eighteen percent of patients in both groups

1993 Ophthalmology Controlled trial quality: uncertain

2416. Mutational analysis of forkhead transcriptional factor 2 (FOXL2) in Korean patients with blepharophimosis-ptosis-epicanthus inversus syndrome. (Abstract)

Mutational analysis of forkhead transcriptional factor 2 (FOXL2) in Korean patients with blepharophimosis-ptosis-epicanthus inversus syndrome. We screened for mutations in the forkhead transcription factor gene, FOXL2, in Korean patients with sporadic or familial blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) by polymerase chain reaction-single-stranded conformation polymorphism (PCR-SSCP) and direct sequencing. Five of nine BPES families and three of seven sporadic cases were

2003 Clinical Genetics

2417. Sporadic and familial blepharophimosis -ptosis-epicanthus inversus syndrome: FOXL2 mutation screen and MRI study of the superior levator eyelid muscle. (Abstract)

Sporadic and familial blepharophimosis -ptosis-epicanthus inversus syndrome: FOXL2 mutation screen and MRI study of the superior levator eyelid muscle. The analysis of the FOXL2 gene (3q23) in a series of two families and two sporadic cases affected with Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome (BPES) is presented. This study detected two novel FOXL2 mutations (missence and nonsens mutations) and confirmed the recurrence of a previously described duplication. Magnetic Resonance

2003 Clinical Genetics

2418. Ptosis as a remote effect of therapeutic botulinum toxin B injection. (Abstract)

Ptosis as a remote effect of therapeutic botulinum toxin B injection. The authors report a patient with cervical dystonia, previously treated with botulinum toxin A (BTX-A), who developed bilateral ptosis and difficulty with accommodation only after botulinum toxin B (BTX-B). High-frequency repetitive nerve stimulation of the abductor digiti minimi demonstrated a 34% increment in compound muscle action potential. No increment in 20 people injected with BTX-A and no cases of ptosis in a chart

2002 Neurology

2419. Long-term results of frontalis suspension using autogenous fascia lata for congenital ptosis in children under 3 years of age. (Abstract)

Long-term results of frontalis suspension using autogenous fascia lata for congenital ptosis in children under 3 years of age. To evaluate the outcome of frontalis suspension surgery for congenital ptosis using autogenous fascia lata for children under 3 years of age.Retrospective nonrandomized interventional case series.This study included nine children (14 eyelids) with severe congenital ptosis aged less than 3 years. All patients underwent frontalis suspension surgery using autogenous fascia (...) lata. Postoperative lid level results, ptosis recurrence, and cosmetic appearance of leg scars were evaluated after the operation.The mean age of the patients was 15.3 months (range, 6 months to 2.5 years) with a mean follow-up period of 41.6 months (range, 18 to 96 months). All children achieved satisfactory cosmetic and functional results, with no postoperative complications such as wound infection, corneal exposure, eyelid contour abnormalities, or ptosis overcorrection. No recurrence of ptosis

2003 American Journal of Ophthalmology

2420. Downgaze "hang-up" of the upper eyelid in patients with adult-onset ptosis: an important sign of possible orbital malignancy. (Abstract)

Downgaze "hang-up" of the upper eyelid in patients with adult-onset ptosis: an important sign of possible orbital malignancy. To highlight, in patients with adult-onset ptosis, the importance of upper eyelid hang-up during downgaze as a clinical sign of serious orbital disease.Retrospective, observational case series.Retrospective review of the presenting clinical symptoms and signs for a series of seven patients, some referred for treatment of adult-onset ptosis, with hang-up of the upper (...) eyelid on down-gaze.All patients had symptoms of upper eyelid ptosis at presentation, starting at ages ranging from 29 to 81 years (mean, 64 years; median, 70 years). All patients displayed marked hang-up of the affected upper lid on downgaze, and the levator excursion was reduced (range, 2-13 mm; mean, 9 mm) compared with the asymptomatic side. All patients with downgaze hang-up had associated orbital malignancy, but they otherwise had only minimal or no underlying orbital disease. Exophthalmometry

2003 Ophthalmology

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