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Pruritus in Pregnancy

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141. Stillbirth care

tests · Anticardiolipin antibodies · Lupus anticoagulant · Anti-B2 glycoprotein-1 antibodies Placental abruption/infarction Pruritus (without rash) in pregnancy and/or Risk factors for obstetric cholestasis LFTs Bile acids Personal/family history of VTE APS** tests LGA HbA1c SGA HbA1c CMV APS** tests Hydropic Anaemic Jaundiced Infections as indicated: · Rubella · Syphilis · Zika · Malaria Check: · Blood group and antibody screen · Kleihauer/flow cytometry result · Parvovirus Fetal anomalies Check (...) : Investigations · Discuss with parents Subsequent pregnancy care · Consider preconception advice/genetic counselling · Offer continuity of care and carer · Detailed history (obstetric, medical, previous stillbirth, family tree) · Lifestyle advice (e.g. smoking, alcohol, drugs, weight loss) · USS–dating and anomaly screeing · Individualise management based on investigations and findings · Consider facility level for anomaly screening · Consider serial growth monitoring (USS) from 28 weeks or earlier

2019 Queensland Health

142. Ciclosporin (Verkazia) - Conjunctivitis, Keratitis

conjunctivitis, infectious conjunctivitis or ocular rosacea in children. Clinically, VKC is characterised by both conjunctival (hyperaemia, oedema, discharge) and corneal signs (superficial keratitis, corneal ulcerations, plaques, scars). Patients have a characteristic ropey, stringy mucous and/or serous discharge. Typical symptoms include photophobia, burning, pruritus, and blepharospasm. Intense ocular itching, followed by tearing and ropey, stringy mucous and/or serous discharge, and foreign body

2018 European Medicines Agency - EPARs

145. Nitisinone (Nityr) - Tyrosinemias

(Reference Product: 5 AEs; Test Product 1: 1 AE; Test Product 2: 3 AEs). The adverse events were mild in intensity. There was no clinically significant and/or consistent drug-related change in vital signs, physical findings or safety laboratory values after administration of a total dose of 10 mg nitisinone per treatment period. Generally the safety data is in line with that of the reference product although an extra patient experienced pruritus with test product 2 versus Test product 1 or reference (...) , Date for submission of interim or final reports (planned or actual) Post-approval surveillance study (PASS)/ Nitisinone Tablets for Hereditary Tyrosinemia type 1 (HT-1) in Canada Category 3 To evaluate the long-term safety of Nitisinone tablets in the treatment of HT-1 and monitor its safety profile during pregnancy Long-term safety of Nitisinone tablets and to monitor its safety profile during pregnancy. Planned Planned Interim update (if the study is started) to be included in ASR to Health

2018 European Medicines Agency - EPARs

148. Erenumab (Aimovig) - Migraine

been observed in both plasma and tumors from specific cancers. The functional significance of the CGRP receptor and the ligand is unclear. However, any role for CGRP would likely be pro-carcinogenic and functional inhibition of CGRP would not be associated with carcinogenic risk. Reproduction Toxicity An enhanced pre- postnatal development study was performed in cynomolgus monkey. There were no AMG 334-related effects on pregnancy/postpartum outcomes. For foetuses that were aborted or stillborn (...) related to immune function, primarily infections in the future PSURs. An enhanced pre- postnatal development study was performed in cynomolgus monkey. It was agreed that this study did not identify any concerns for use during pregnancy. However, CGRP may be of importance to regulate uterine vascular resistance during pregnancy. There is a theoretical risk that CGRP inhibition may be a risk in pregnant women with risk factors for eclampsia. Based on such theoretical concerns, and also a more general

2018 European Medicines Agency - EPARs

150. Vestronidase alfa (Mepsevii) - Mucopolysaccharidosis VII

(47.8%), vomiting (47.8%), upper respiratory tract infection (43.5%), infusion site extravasation (34.8%), rash (30.4%), diarrhoea (30.4%) and pyrexia (30.4%). The most common adverse reactions from 4 clinical trials in patients treated with Mepsevii were anaphylactoid reaction (13%), urticaria (13%), infusion site swelling (13%), infusion site extravasation (8.7%), pruritus (8.7%), diarrhoea (8.7%) and rash (8.7%). Serious adverse event/deaths/other significant events No deaths were reported in any

2018 European Medicines Agency - EPARs

151. Varicella Zoster Virus glycoprotein E antigen (Shingrix) - Herpes Zoster

70 years having a four times increased risk of PHN than those younger than 60 years. Besides increase in age, immunosuppression from any cause, including hematologic malignancies, HIV and immunosuppressive medications, is an important risk factor for herpes zoster, increasing the risk of HZ by at least 10-fold. An increased risk of HZ has been reported in infants whose mothers had had varicella in pregnancy. Prompt antiviral therapy, if available, is recommended for herpes zoster in healthy

2018 European Medicines Agency - EPARs

152. Grazoprevir with elbasvir (Zepatier): fixed-dose combination for chronic

overdose, anaemia and pruritus were reported to be more common in the groups receiving ribavirin-containing treatment than in those without ribavirin. There was a low incidence of serious adverse events across studies, occurring at similar rates between patients receiving the ribavirin-containing and ribavirin-free regimens (1% to 3.1%). , , , Few patients discontinued treatment due to adverse events (1% to 1.7%). , , , For information about reporting adverse reactions to the TGA, or to report (...) , contraindications and precautions. Pregnancy category B1 There are no adequate or well-controlled studies of GRZ/EBR in pregnant women. GRZ/EBR should only be used in pregnancy if the potential benefit justifies the potential risk to the fetus. There is also a lack of information on whether GRZ/EBR is excreted in human breast milk, which requires careful consideration of benefits and risks. Reason for PBS listing The PBAC recommended the Authority required listing of grazoprevir with elbasvir for the treatment

2018 National Prescribing Service Limited (Australia)

153. Antiocoagulation - oral

Antiocoagulation - oral Prodigy Toggle navigation Topics Specialities A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Allergies Cancer Cardiovascular Child health Drugs and devices Ear, nose and throat Endocrine and metabolic Eyes Gastroenterology Gastrointestinal Haematology Immunizations Infections and infestations Injuries Kidney disease and urology Men's health Mental health Musculoskeletal Neurological Oral health Palliative care Poisoning Pregnancy Preventative medicine Respiratory

2017 Prodigy

154. Guidelines for the Management of Genital Herpes in New Zealand

2017 Only available online at www.herpes.org.nz 2. Sexually Transmitted Infections – Summary of Guidelines 2017 Patient information pamphlets 1. The Facts: A guide for people with Herpes Simplex Includes – Genital Herpes – The Facts Herpes and Relationships Herpes and Pregnancy Facial Herpes 2. Herpes: Myth vs Facts Helpline Website Resources New Zealand Sexual Health Society (NZSHS) resources Comprehensive STI Management Guidelines and Patient Information handouts are available on www.nzshs.org (...) – Management of Recurrent Episodes of Genital Herpes 18 GENITAL HERPES IN PREGNANCY 18 Maternal Fetal Transmission 19 Use of Antivirals in Pregnancy and Breastfeeding 19 Mode of Delivery 21 Special Situations in Pregnancy 21 Prevention of HSV in the Neonate 21 Summary of Clinical Management of First Episode Genital Herpes in Pregnancy 22 Treatment algorithm – Management of Women with Suspected Genital Herpes in Pregnancy 23 First Episode Genital Herpes: First and Second Trimester Acquisition 23 First

2017 New Zealand Sexual Health Society

155. BSG and UKPBC primary biliary cholangitis treatment and management guidelines

auto- immune liver disease. It continues to have a burden of morbidity and mortality that spans both the consequences of a sometimes progressive biliary injury, alongside a symptom profile notably encom- passing pruritus, sicca complex, fatigue, abdominal discomfort and arthralgias/bone pain. UK-PBC and the British Society of Gastroenterology (BSG) have partnered to develop a comprehensive guideline document to provide detailed advice and recom- mendations on the best approaches to the manage- ment (...) in isolation is not a highly predictive surrogate marker for risk of death in PBC. A detailed review of liver histology suggests that the presence of a lymphoplasmacytic interface hepatitis is a marker of more rapidly progressive disease 14 96 and, in another report of four cases, rapidly progressive bile duct loss, even in the absence of cirrhosis, led to liver failure; this is the so-called ‘pre-cirrhotic ductopenic’ variant of PBC, characteristic of early onset symptomatic (pruritus) disease. 127

2018 British Society of Gastroenterology

157. Evaluation and Treatment of Hirsutism in Premenopausal Women

, and treatable ( e.g. , pregnancy, nonclassic congenital adrenal hyperplasia, ovarian or adrenal neoplasm, or other endocrinopathies). The most common of these is nonclassic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (as noted in Section 1, Etiology and Section 5, Androgen Testing Remarks). This is particularly important to detect because of its genetic implications for those women desiring fertility ( ). We suggest screening hyperandrogenemic women for nonclassic congenital adrenal (...) in detail ( ). Different subspecialists use different strategies for evaluating the patient with hirsutism ( , ). The evaluation of hyperandrogenemic women may include the following: pregnancy tests in patients with amenorrhea; measuring dehydroepiandrosterone (DHEA) sulfate (DHEAS) to screen for adrenal hyperandrogenism; assessing for Cushing syndrome, thyroid dysfunction, acromegaly, and hyperprolactinemia if features of these conditions are present (however, all are uncommon causes of hirsutism

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2018 The Endocrine Society

159. Evaluation and Treatment of Hirsutism in Premenopausal Women

, and treatable ( e.g. , pregnancy, nonclassic congenital adrenal hyperplasia, ovarian or adrenal neoplasm, or other endocrinopathies). The most common of these is nonclassic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (as noted in Section 1, Etiology and Section 5, Androgen Testing Remarks). This is particularly important to detect because of its genetic implications for those women desiring fertility ( ). We suggest screening hyperandrogenemic women for nonclassic congenital adrenal (...) in detail ( ). Different subspecialists use different strategies for evaluating the patient with hirsutism ( , ). The evaluation of hyperandrogenemic women may include the following: pregnancy tests in patients with amenorrhea; measuring dehydroepiandrosterone (DHEA) sulfate (DHEAS) to screen for adrenal hyperandrogenism; assessing for Cushing syndrome, thyroid dysfunction, acromegaly, and hyperprolactinemia if features of these conditions are present (however, all are uncommon causes of hirsutism

Full Text available with Trip Pro

2018 The Endocrine Society

160. Flowchart: Stillbirth care, PSANZ investigations

autopsy • Needle biopsies, laparoscopic autopsy or access to tissue from small incisions Findings Selective investigations **APS tests–Antiphospholipid syndrome tests • Anticardiolipin antibodies • Lupus anticoagulant • Anti-B2 glycoprotein-1 antibodies Placental abruption/infarction Pruritus (without rash) in pregnancy and/or Risk factors for obstetric cholestasis LFTs Bile acids Personal/family history of VTE APS** tests LGA HbA1c SGA HbA1c CMV APS** tests Hydropic Anaemic Jaundiced Infections

2018 Queensland Health

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