How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,058 results for

Pruritus in Pregnancy

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

101. Pregabalin for the Treatment of Uremic Pruritus

Pregabalin for the Treatment of Uremic Pruritus Pregabalin for the Treatment of Uremic Pruritus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pregabalin for the Treatment of Uremic Pruritus The safety (...) General Hospital Information provided by (Responsible Party): National Taiwan University Hospital Study Details Study Description Go to Brief Summary: Pruritus s a very distressing problem affecting patients with uremia and the prevalence of uremic pruritus (UP) ranges between 22% to 66%. Although some studies suggested pruritus is being decreased recently by use of better dialysis techniques, accumulating studies have shown the still high prevalence of UP. Because of its long duration, frequency

2013 Clinical Trials

102. Impact of Vorinostat on Pruritus Signaling Pathways

vorinostat according to the stand-of-care guidelines. Criteria Inclusion Criteria: Patients w/ histologically confirmed mycosis fungoides stage IB to IVA eligible to receive oral vorinostat Patients w/ stage IB to IV reporting pruritus Patients age 18-85 years, of any race, sex, and ethnicity Life expectancy > 24 weeks Patient must have performance status of ≤2 on the ECOG Performance Scale Patients w/ a min. of 3 weeks since their last systemic treatment Women who are not pregnant, lactating (...) Impact of Vorinostat on Pruritus Signaling Pathways Impact of Vorinostat on Pruritus Signaling Pathways - Merck Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Impact of Vorinostat on Pruritus

2013 Clinical Trials

103. Pruritus in cholestasis - facts and fiction. Full Text available with Trip Pro

Pruritus in cholestasis - facts and fiction. Pruritus is a common symptom in patients with cholestatic liver diseases such as primary biliary cirrhosis, primary sclerosing cholangitis, intrahepatic cholestasis of pregnancy, or hereditary pediatric cholestatic disorders and may accompany, although less frequently, many other liver diseases. Recent findings indicate that lysophosphatidic acid (LPA), a potent neuronal activator, and autotaxin (ATX; ectonucleotide pyrophosphatase/phosphodiesterase (...) 2), the enzyme which forms LPA, may form a key element of the long-sought pruritogenic signaling cascade in cholestatic patients suffering from itch. Serum ATX, but no other pruritogen candidate studied so far, correlates with pruritus intensity and responds to therapeutic interventions. In this comprehensive review, we provide a short update on actual insights in signal transmission related to pruritus and discuss pruritogen candidates in cholestasis. We also summarize evidence-based

2013 Hepatology

104. Cholestasis associated Pruritus

VI. Management (or if limited) Has also been used in of pregnancy Used in primary biliary (intense itch) May be indicated in refractory cases receptor antagonist IV PO VII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Cholestasis associated Pruritus." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Dermatology About (...) Cholestasis associated Pruritus Cholestasis associated Pruritus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cholestasis associated

2015 FP Notebook

105. Pruritus Causes

water contact (follows warm bath) Pregnancy (See ) Prurigo of Pregnancy or ( ) Pruritic of Pregnancy Medications , , B s Ointments with high concentrations of inert oil s (especially via spinal administration) Allergen or irritant exposure (e.g. ) Heat exposure: ( ) Cat exposure glass exposure ( glass Dermatitis) VI. Causes: Age-related Pruritus Children s Elderly VII. References See Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term (...) Pruritus Causes Pruritus Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pruritus Causes Pruritus Causes Aka: Pruritus Causes

2015 FP Notebook

106. Effect of Neurokinin-1 Receptor (NK1R) Antagonism on Pruritus in Patients With Sezary Syndrome

for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Known Sezary Syndrome Pruritus uncontrolled by conventional treatment. Baseline visual analogue scale > 4. Age 18 through 80 years of age. Stable medication regimens for both Sezary Syndrome and pruritus for 3 months prior to study participation. Exclusion Criteria: Known hepatic impairment (defined as liver function tests >3 times the upper limit of normal). Pregnancy (all women of child-bearing potential will undergo urine beta (...) Effect of Neurokinin-1 Receptor (NK1R) Antagonism on Pruritus in Patients With Sezary Syndrome Effect of Neurokinin-1 Receptor (NK1R) Antagonism on Pruritus in Patients With Sezary Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2012 Clinical Trials

107. Efficacy and Safety of MT-9938 for Treatment of Uremic Pruritus in Subjects With End-stage Renal Disease Receiving Hemodialysis

Efficacy and Safety of MT-9938 for Treatment of Uremic Pruritus in Subjects With End-stage Renal Disease Receiving Hemodialysis Efficacy and Safety of MT-9938 for Treatment of Uremic Pruritus in Subjects With End-stage Renal Disease Receiving Hemodialysis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy and Safety of MT-9938 for Treatment of Uremic Pruritus in Subjects With End-stage Renal Disease Receiving Hemodialysis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01660243 Recruitment Status

2012 Clinical Trials

108. Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy: a randomized controlled trial. (Abstract)

Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy: a randomized controlled trial. To test the efficacy and safety of ursodeoxycholic acid (UDCA) in the treatment of patients with intrahepatic cholestasis of pregnancy (ICP).In the randomized (double-blind, placebo-controlled) study 20 pregnant women with ICP received (random allocation of) either 450 mg/day UDCA or placebo for 14 days during the third trimester of pregnancy. The severity of pruritus was registered (...) on pregnancy and delivery outcome were recorded and analyzed.UDCA was well tolerated. A significant improvement in itching scores was detected in 2 weeks in the group receiving UDCA. Serum levels of ALAT and TBA fell after 2 weeks treatment. The other laboratory values were not modified by the treatment.UDCA improves maternal itching scores and liver function tests without interfering with the fetoplacental estrogen production in patients with ICP. UDCA is well tolerated by pregnant women. No fetal

2014 Archives of gynecology and obstetrics Controlled trial quality: predicted high

109. Intrahepatic Cholestasis Of Pregnancy: Maternal and Fetal Outcomes Associated With Elevated Bile Acid Levels. (Abstract)

Intrahepatic Cholestasis Of Pregnancy: Maternal and Fetal Outcomes Associated With Elevated Bile Acid Levels. The primary aim of this study was to investigate the correlation between pregnancy outcome and bile acid (BA) levels in pregnancies that were affected by intrahepatic cholestasis of pregnancy (ICP). In addition, correlations between maternal and fetal BA levels were explored.We conducted a retrospective study that included women with pruritus and BA levels ≥10 μmol/L between January (...) % CI, 1.01-1.57). Maternal BA levels at diagnosis and at delivery were correlated positively with umbilical cord blood BA levels (P = .006 and .012, respectively).Severe ICP is associated with adverse pregnancy outcome. Levels of BA correlate between mother and fetus.Copyright © 2015 Elsevier Inc. All rights reserved.

2014 American Journal of Obstetrics and Gynecology

110. Autotaxin Activity has a high Accuracy to diagnose Intrahepatic Cholestasis of Pregnancy. (Abstract)

), and pregnant controls (19.6 ± 5.7 nmol ml(-1)min(-1), n=44). Longitudinal analysis during pregnancy revealed a marked rise in serum autotaxin with onset of ICP-related pruritus. Serum autotaxin was increased in women taking oral contraceptives. Increased serum autotaxin during ICP was not associated with increased autotaxin mRNA in placenta. With a cut-off value of 27.0 nmol ml(-1)min(-1), autotaxin had an excellent sensitivity and specificity in distinguishing ICP from other pruritic disorders or pre (...) Autotaxin Activity has a high Accuracy to diagnose Intrahepatic Cholestasis of Pregnancy. Intrahepatic cholestasis of pregnancy (ICP) is defined by pruritus, elevated total fasting serum bile salts (TBS) and transaminases, and an increased risk of adverse fetal outcome. An accurate diagnostic marker is needed. Increased serum autotaxin correlates with cholestasis-associated pruritus. We aimed at unraveling the diagnostic accuracy of autotaxin in ICP.Serum samples and placental tissue were

2014 Journal of Hepatology

111. Pregnancy in women with primary biliary cirrhosis. (Abstract)

% and three stillbirths were reported. Most patients were treated with ursodeoxycholic acid (UDCA) during breastfeeding and 12 patients also received UDCA during the first trimester without any identified side effects.Most women with PBC maintain a stable disease during pregnancy, but post-partum biochemical flares are common. Symptomatic pruritus may be challenging in pregnant PBC patients. UDCA appears to be safe during pregnancy and breastfeeding. A successful pregnancy outcome is a realistic (...) patients. PBC was diagnosed during pregnancy in 26 (36%) patients and 46 (64%) had the diagnosis before conception. Twenty-four (30%) of the pregnancies were associated with biochemical flares and 55 (70%) with clinical improvement or stabilization. De novo onset or worsening of pruritus was seen in 49% (45/92). No maternal deaths were reported. Post-partum disease activation was observed in 60% (53/88). One patient was referred for liver transplantation after delivery. A miscarriage rate of 24

2014 Autoimmunity reviews

112. Liver Disease and Pregnancy (Diagnosis)

), intrahepatic cholestasis of pregnancy (ICP), and hemolysis and elevated liver enzymes and low platelets (HELLP) syndrome. [ ] Liver disease such as acute viral hepatitis can occur in pregnancy, and pregnancy may occur in a patient with underlying chronic liver disease, including patients with cirrhosis and portal hypertension, and patients who have undergone liver transplantation. In the initial evaluation of a pregnant patient with abnormal liver tests, the American College of Gastroenterology (ACG (...) and childhood hematologic malignancies but may be used judiciously with minimized radiation protocols (2-5 rads). Endoscopy is safe in pregnancy but should be deferred until the second trimester if possible. Meperidine and propofol can be used for endoscopic sedation. Next: Hyperemesis Gravidarum Approximately 50%-80% of pregnant women experience nausea, and an estimated 50% suffer from retching. [ , ] —in which persistent vomiting is associated with a 5% or more loss of prepregnancy body weight

2014 eMedicine.com

113. Pruritic Urticarial Papules and Plaques of Pregnancy (Diagnosis)

of an unusual skin eruption in pregnancy can provoke anxiety, but the pruritus is the most distressing feature. The later weeks of pregnancy can be associated with many physical symptoms, and the severe itching of PEP may further debilitate and aggravate sleep loss in the weeks prior to delivery. No known systemic complications exist for affected females, and fetal mortality or morbidity do not increase. Previous Next: Patient Education The patient should understand that PEP is a benign disorder and has (...) . . Bourne G. Toxaemic rash of pregnancy. Proc R Soc Med . 1962 Jun. 55:462-4. . Ambros-Rudolph CM, Mullegger RR, Vaughan-Jones SA, Kerl H, Black MM. The specific dermatoses of pregnancy revisited and reclassified: results of a retrospective two-center study on 505 pregnant patients. J Am Acad Dermatol . 2006 Mar. 54(3):395-404. . Roth MM. Pregnancy dermatoses: diagnosis, management, and controversies. Am J Clin Dermatol . 2011 Feb 1. 12(1):25-41. . Rudolph CM, Al-Fares S, Vaughan-Jones SA, Mullegger RR

2014 eMedicine.com

114. Pruritic Urticarial Papules and Plaques of Pregnancy (Overview)

of an unusual skin eruption in pregnancy can provoke anxiety, but the pruritus is the most distressing feature. The later weeks of pregnancy can be associated with many physical symptoms, and the severe itching of PEP may further debilitate and aggravate sleep loss in the weeks prior to delivery. No known systemic complications exist for affected females, and fetal mortality or morbidity do not increase. Previous Next: Patient Education The patient should understand that PEP is a benign disorder and has (...) . . Bourne G. Toxaemic rash of pregnancy. Proc R Soc Med . 1962 Jun. 55:462-4. . Ambros-Rudolph CM, Mullegger RR, Vaughan-Jones SA, Kerl H, Black MM. The specific dermatoses of pregnancy revisited and reclassified: results of a retrospective two-center study on 505 pregnant patients. J Am Acad Dermatol . 2006 Mar. 54(3):395-404. . Roth MM. Pregnancy dermatoses: diagnosis, management, and controversies. Am J Clin Dermatol . 2011 Feb 1. 12(1):25-41. . Rudolph CM, Al-Fares S, Vaughan-Jones SA, Mullegger RR

2014 eMedicine.com

115. Common Pregnancy Complaints and Questions (Overview)

pregnancies, worsening cramping, or cramping associated with any vaginal bleeding may be a sign of , , or . Other physical effects that are normal during pregnancy, and not necessarily signs of disease, include nausea, vomiting, increase in abdominal girth, changes in bowel habits, increased urinary frequency, palpitations or more rapid heartbeat, upheaving of the chest (particularly with breathing), heart murmurs, swelling of the ankles, and shortness of breath. [ ] Why do pregnant women feel tired (...) . This is not accompanied by any functional osteoporosis, although pregnancy is a very high bone turnover state, approximately equivalent to double the bone loss rates of a menopausal female, reversibly losing about 2% of bone during the first 20 weeks of gestation. Spinal changes are usually not severe enough to affect the pregnancy or the lung's functional capacity. Also, the pregnancy rarely affects the degree of lateral curvature in these cases of scoliosis. If a pregnant patient has had correction with prior

2014 eMedicine.com

116. Common Pregnancy Complaints and Questions (Treatment)

pregnancies, worsening cramping, or cramping associated with any vaginal bleeding may be a sign of , , or . Other physical effects that are normal during pregnancy, and not necessarily signs of disease, include nausea, vomiting, increase in abdominal girth, changes in bowel habits, increased urinary frequency, palpitations or more rapid heartbeat, upheaving of the chest (particularly with breathing), heart murmurs, swelling of the ankles, and shortness of breath. [ ] Why do pregnant women feel tired (...) . This is not accompanied by any functional osteoporosis, although pregnancy is a very high bone turnover state, approximately equivalent to double the bone loss rates of a menopausal female, reversibly losing about 2% of bone during the first 20 weeks of gestation. Spinal changes are usually not severe enough to affect the pregnancy or the lung's functional capacity. Also, the pregnancy rarely affects the degree of lateral curvature in these cases of scoliosis. If a pregnant patient has had correction with prior

2014 eMedicine.com

117. Pruritic Urticarial Papules and Plaques of Pregnancy (Treatment)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEyMzcyNS10cmVhdG1lbnQ= processing > Polymorphic Eruption of Pregnancy Treatment & Management Updated: May 14, 2018 Author: Joseph C Pierson, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Polymorphic Eruption of Pregnancy Treatment Approach Considerations Treatment is directed at relieving the pruritus associated with polymorphic eruption of pregnancy (PEP). Topical corticosteroids are the mainstay of treatment. [ ] High-potency topical (class I or II), or even systemic (...) of pregnancy. JAMA . 1979 Apr 20. 241(16):1696-9. . Bourne G. Toxaemic rash of pregnancy. Proc R Soc Med . 1962 Jun. 55:462-4. . Ambros-Rudolph CM, Mullegger RR, Vaughan-Jones SA, Kerl H, Black MM. The specific dermatoses of pregnancy revisited and reclassified: results of a retrospective two-center study on 505 pregnant patients. J Am Acad Dermatol . 2006 Mar. 54(3):395-404. . Roth MM. Pregnancy dermatoses: diagnosis, management, and controversies. Am J Clin Dermatol . 2011 Feb 1. 12(1):25-41. . Rudolph

2014 eMedicine.com

118. Liver Disease and Pregnancy (Treatment)

), intrahepatic cholestasis of pregnancy (ICP), and hemolysis and elevated liver enzymes and low platelets (HELLP) syndrome. [ ] Liver disease such as acute viral hepatitis can occur in pregnancy, and pregnancy may occur in a patient with underlying chronic liver disease, including patients with cirrhosis and portal hypertension, and patients who have undergone liver transplantation. In the initial evaluation of a pregnant patient with abnormal liver tests, the American College of Gastroenterology (ACG (...) and childhood hematologic malignancies but may be used judiciously with minimized radiation protocols (2-5 rads). Endoscopy is safe in pregnancy but should be deferred until the second trimester if possible. Meperidine and propofol can be used for endoscopic sedation. Next: Hyperemesis Gravidarum Approximately 50%-80% of pregnant women experience nausea, and an estimated 50% suffer from retching. [ , ] —in which persistent vomiting is associated with a 5% or more loss of prepregnancy body weight

2014 eMedicine.com

119. Liver Disease and Pregnancy (Overview)

), intrahepatic cholestasis of pregnancy (ICP), and hemolysis and elevated liver enzymes and low platelets (HELLP) syndrome. [ ] Liver disease such as acute viral hepatitis can occur in pregnancy, and pregnancy may occur in a patient with underlying chronic liver disease, including patients with cirrhosis and portal hypertension, and patients who have undergone liver transplantation. In the initial evaluation of a pregnant patient with abnormal liver tests, the American College of Gastroenterology (ACG (...) and childhood hematologic malignancies but may be used judiciously with minimized radiation protocols (2-5 rads). Endoscopy is safe in pregnancy but should be deferred until the second trimester if possible. Meperidine and propofol can be used for endoscopic sedation. Next: Hyperemesis Gravidarum Approximately 50%-80% of pregnant women experience nausea, and an estimated 50% suffer from retching. [ , ] —in which persistent vomiting is associated with a 5% or more loss of prepregnancy body weight

2014 eMedicine.com

120. Pruritic Urticarial Papules and Plaques of Pregnancy (Follow-up)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEyMzcyNS10cmVhdG1lbnQ= processing > Polymorphic Eruption of Pregnancy Treatment & Management Updated: May 14, 2018 Author: Joseph C Pierson, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Polymorphic Eruption of Pregnancy Treatment Approach Considerations Treatment is directed at relieving the pruritus associated with polymorphic eruption of pregnancy (PEP). Topical corticosteroids are the mainstay of treatment. [ ] High-potency topical (class I or II), or even systemic (...) of pregnancy. JAMA . 1979 Apr 20. 241(16):1696-9. . Bourne G. Toxaemic rash of pregnancy. Proc R Soc Med . 1962 Jun. 55:462-4. . Ambros-Rudolph CM, Mullegger RR, Vaughan-Jones SA, Kerl H, Black MM. The specific dermatoses of pregnancy revisited and reclassified: results of a retrospective two-center study on 505 pregnant patients. J Am Acad Dermatol . 2006 Mar. 54(3):395-404. . Roth MM. Pregnancy dermatoses: diagnosis, management, and controversies. Am J Clin Dermatol . 2011 Feb 1. 12(1):25-41. . Rudolph

2014 eMedicine.com

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>