How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,634 results for

Pruritus in Pregnancy

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

81. Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG)

Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG) Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search (...) for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG) (PCEA-IMG) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean

2015 Clinical Trials

82. Pregnancy and primary biliary cirrhosis: a case-control study. (PubMed)

in terms of miscarriages, voluntary interruptions of pregnancy, and term and preterm deliveries. The rates for one or more cesarean deliveries were lower for PBC patients (5.7 vs 11.7 %, p < 0.05). Pruritus during pregnancy was recorded in 15 pregnancies involving 13 PBC patients (3.0 %) and none of the controls. Perinatal and postnatal deaths and complications at childbirth were only recorded in the PBC patients, involving a total of 11 babies (2.7 %, p < 0.05). Eight pregnancies occurred after PBC (...) Pregnancy and primary biliary cirrhosis: a case-control study. A very critical feature in women's health is the identification of risk factors for pregnancy and adverse fetal outcome. Primary biliary cirrhosis is an autoimmune disease of the liver that predominantly affects older women. However, the serologic onset of this disease appears to precede clinical manifestations by many years. The goal of this case controlled study was to analyze fertility in primary biliary cirrhosis (PBC

Full Text available with Trip Pro

2015 Clinical Reviews in Allergy & Immunology

83. Pregnancy Registry to Collect Long-Term Safety Data From Women Treated With HyQvia

immunoglobulin or alternative treatment Incidence of local/immunologic adverse events (expectant mother) [ Time Frame: Up to approximately 40 weeks, ie throughout pregnancy, and up to 6 months after delivery for final / study close out visit ] Including skin changes (such as: local erythema, local pruritus, induration, nodules) Development of anti-rHuPH20 antibodies (rHuPH20 binding and neutralizing antibodies) (expectant mother) [ Time Frame: Up to approximately 40 weeks, ie throughout pregnancy, and up (...) Pregnancy Registry to Collect Long-Term Safety Data From Women Treated With HyQvia Pregnancy Registry to Collect Long-Term Safety Data From Women Treated With HyQvia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2015 Clinical Trials

84. Serum Autotaxin Levels in Cholestasis of Pregnancy

Training and Research Hospital Information provided by (Responsible Party): Hakan Erenel, Sisli Hamidiye Etfal Training and Research Hospital Study Details Study Description Go to Brief Summary: Intrahepatic cholestasis of pregnancy is the most common liver disease in pregnancy. It is is a pregnancy-specific liver disorder with onset mainly in the third trimester of pregnancy. ICP is characterized by pruritus, elevated serum fasting bile salts and transaminases and an increased risk of adverse fetal (...) Serum Autotaxin Levels in Cholestasis of Pregnancy Serum Autotaxin Levels in Cholestasis of Pregnancy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Serum Autotaxin Levels in Cholestasis of Pregnancy

2015 Clinical Trials

85. Review of a challenging clinical issue: Intrahepatic cholestasis of pregnancy (PubMed)

Review of a challenging clinical issue: Intrahepatic cholestasis of pregnancy Intrahepatic cholestasis of pregnancy (ICP) is a reversible pregnancy-specific cholestatic condition characterized by pruritus, elevated liver enzymes, and increased serum bile acids. It commences usually in the late second or third trimester, and quickly resolves after delivery. The incidence is higher in South American and Scandinavian countries (9.2%-15.6% and 1.5%, respectively) than in Europe (0.1%-0.2

Full Text available with Trip Pro

2015 World journal of gastroenterology : WJG

86. Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis (PubMed)

Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis We performed a meta-analysis to evaluate the effects of ursodeoxycholic acid (UDCA) on pruritus, liver test results, and outcomes of babies born to women with intrahepatic cholestasis of pregnancy (ICP).We performed a systematic review of 9 published, randomized controlled trials (3 double blinded) that compared the effects of UDCA to other drugs, placebo, or no specific treatment (controls (...) with those of placebos.In pooled analyses that compared UDCA with all controls, UDCA was associated with total resolution of pruritus (odds ratio [OR], 0.23; 95% confidence interval [CI], 0.07-0.74; P < .01), reduced pruritis (OR, 0.27; 95% CI, 0.13-0.55; P < .0001), normalization of serum levels of alanine aminotransferase (ALT) (OR, 0.23; 95% CI, 0.10-0.50; P < .001), decreased serum level of ALT (OR, 0.24; 95% CI, 0.11-0.52; P < .0001), reduced serum levels of bile acids (OR, 0.37; 95% CI, 0.19-0.75

Full Text available with Trip Pro

2012 EvidenceUpdates

87. Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial. (PubMed)

Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial. Intrahepatic cholestasis of pregnancy (ICP) is a special complication of pregnancy characterized by skin pruritus, abnormal liver function tests and bile acids. To compare the efficacy of ursodeoxycholic acid (UDCA) and S-adenosylmethionine (SAMe) monotherapy with their combined effect on intrahepatic cholestasis of pregnancy (ICP).Singleton (...) pregnancies with ICP in five tertiary medical centers were randomly divided into three treatment groups: oral UDCA 4×250 mg daily (Group 1, n = 41), intravenous SAMe 1000 mg daily (Group 2, n = 38), and a combination of both drugs (Group 3, n = 41) until delivery. Paired t test, analysis of covariance and non-parametric test were used.All therapies significantly and equally improved pruritus. The serum levels of total bile acids (TBA), alanine aminotransferase (ALT), aspartate aminotransferase (AST

2015 European review for medical and pharmacological sciences Controlled trial quality: uncertain

88. A randomized trial of artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in pregnancy. (PubMed)

A randomized trial of artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in pregnancy. To compare the artesunate-amodiaquine and artemether-lumefantrine combinations in the treatment of acute uncomplicated falciparum malaria during pregnancy.Between January and July, 2013, a double-blind randomized trial was undertaken of symptomatic pregnant women (second/third trimester) with malaria parasitemia who attended a center in Ile-Ife, Nigeria (...) in the artesunate-amodiaquine group and 71 in the artemether-lumefantrine group completed the study. No significant differences between the artesunate-amodiaquine and artemether-lumefantrine groups were recorded for mean interval to symptomatic relief (2.2 ± 1.0 days vs 2.0 ± 0.8 days; P=0.090), day-3 parasite clearance (58/65 [89.2%] vs 66/71 [93.0%]; P=0.444), and day-28 cure rate (64/65 [98.5%] vs 67/71 [94.4%]; P=0.138). Adverse effects (body weakness and pruritus) were more common among women assigned

2015 International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Controlled trial quality: predicted high

89. Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial. (PubMed)

Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial. To test whether ursodeoxycholic acid reduces pruritus in women with intrahepatic cholestasis of pregnancy, whether early term delivery does not increase the incidence of caesarean section, and the feasibility of recruiting women with intrahepatic cholestasis of pregnancy to trials of these interventions.First (...) phase of a semifactorial randomised controlled trial.Nine consultant led maternity units, United Kingdom.125 women with intrahepatic cholestasis of pregnancy (pruritus and raised levels of serum bile acids) or pruritus and raised alanine transaminase levels (>100 IU/L) recruited after 24 weeks' gestation and followed until delivery. 56 women were randomised to ursodeoxycholic acid, 55 to placebo, 30 to early term delivery, and 32 to expectant management.Ursodeoxycholic acid 500 mg twice daily

Full Text available with Trip Pro

2012 BMJ Controlled trial quality: predicted high

90. The effects of ursodeoxycholic Acid treatment for intrahepatic cholestasis of pregnancy on maternal and fetal outcomes: a meta-analysis including non-randomized studies. (PubMed)

treatments, and all NRSs comparing UDCA with any other treatment in women with ICP.We included 11 RCTs (n = 625 pregnancies) and six NRSs (n = 211 pregnancies). The women included in RCTs and NRSs were comparable, but study quality was poorer for NRSs. Overall, women treated with UDCA had decreased pruritus in 73% of RCTs and in 100% of NRSs with available data. Liver function tests were improved in 82% of RCTs and in 100% of NRSs with available data. UDCA use did not affect the Caesarean section rate (...) The effects of ursodeoxycholic Acid treatment for intrahepatic cholestasis of pregnancy on maternal and fetal outcomes: a meta-analysis including non-randomized studies. The benefits of ursodeoxycholic acid (UDCA) use for treating intra-hepatic cholestasis of pregnancy (ICP) remain uncertain. A 2010 Cochrane Review of randomized control trials was unable to recommend either for or against the use of UDCA in treating ICP. We conducted a meta-analysis of the literature, including both non

2014 Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC

91. Autotaxin Activity has a high Accuracy to diagnose Intrahepatic Cholestasis of Pregnancy. (PubMed)

Autotaxin Activity has a high Accuracy to diagnose Intrahepatic Cholestasis of Pregnancy. Intrahepatic cholestasis of pregnancy (ICP) is defined by pruritus, elevated total fasting serum bile salts (TBS) and transaminases, and an increased risk of adverse fetal outcome. An accurate diagnostic marker is needed. Increased serum autotaxin correlates with cholestasis-associated pruritus. We aimed at unraveling the diagnostic accuracy of autotaxin in ICP.Serum samples and placental tissue were (...) collected from 44 women with uncomplicated pregnancies and 105 with pruritus and/or elevated serum transaminases. Autotaxin serum levels were quantified enzymatically and by Western blotting, autotaxin gene expression by quantitative PCR.Serum autotaxin was increased in ICP (mean ± SD: 43.5 ± 18.2 nmol ml(-1)min(-1), n=55, p<0.0001) compared to other pruritic disorders of pregnancy (16.8 ± 6.7 nmol ml(-1)min(-1), n=33), pre-eclampsia complicated by HELLP-syndrome (16.8 ± 8.9 nmol ml(-1)min(-1), n=17

2014 Journal of Hepatology

92. Intrahepatic Cholestasis Of Pregnancy: Maternal and Fetal Outcomes Associated With Elevated Bile Acid Levels. (PubMed)

Intrahepatic Cholestasis Of Pregnancy: Maternal and Fetal Outcomes Associated With Elevated Bile Acid Levels. The primary aim of this study was to investigate the correlation between pregnancy outcome and bile acid (BA) levels in pregnancies that were affected by intrahepatic cholestasis of pregnancy (ICP). In addition, correlations between maternal and fetal BA levels were explored.We conducted a retrospective study that included women with pruritus and BA levels ≥10 μmol/L between January (...) % CI, 1.01-1.57). Maternal BA levels at diagnosis and at delivery were correlated positively with umbilical cord blood BA levels (P = .006 and .012, respectively).Severe ICP is associated with adverse pregnancy outcome. Levels of BA correlate between mother and fetus.Copyright © 2015 Elsevier Inc. All rights reserved.

2014 American Journal of Obstetrics and Gynecology

93. Pregnancy in women with primary biliary cirrhosis. (PubMed)

patients. PBC was diagnosed during pregnancy in 26 (36%) patients and 46 (64%) had the diagnosis before conception. Twenty-four (30%) of the pregnancies were associated with biochemical flares and 55 (70%) with clinical improvement or stabilization. De novo onset or worsening of pruritus was seen in 49% (45/92). No maternal deaths were reported. Post-partum disease activation was observed in 60% (53/88). One patient was referred for liver transplantation after delivery. A miscarriage rate of 24 (...) % and three stillbirths were reported. Most patients were treated with ursodeoxycholic acid (UDCA) during breastfeeding and 12 patients also received UDCA during the first trimester without any identified side effects.Most women with PBC maintain a stable disease during pregnancy, but post-partum biochemical flares are common. Symptomatic pruritus may be challenging in pregnant PBC patients. UDCA appears to be safe during pregnancy and breastfeeding. A successful pregnancy outcome is a realistic

2014 Autoimmunity reviews

94. Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy: a randomized controlled trial. (PubMed)

Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy: a randomized controlled trial. To test the efficacy and safety of ursodeoxycholic acid (UDCA) in the treatment of patients with intrahepatic cholestasis of pregnancy (ICP).In the randomized (double-blind, placebo-controlled) study 20 pregnant women with ICP received (random allocation of) either 450 mg/day UDCA or placebo for 14 days during the third trimester of pregnancy. The severity of pruritus was registered (...) on pregnancy and delivery outcome were recorded and analyzed.UDCA was well tolerated. A significant improvement in itching scores was detected in 2 weeks in the group receiving UDCA. Serum levels of ALAT and TBA fell after 2 weeks treatment. The other laboratory values were not modified by the treatment.UDCA improves maternal itching scores and liver function tests without interfering with the fetoplacental estrogen production in patients with ICP. UDCA is well tolerated by pregnant women. No fetal

2014 Archives of gynecology and obstetrics Controlled trial quality: predicted high

95. Common Pregnancy Complaints and Questions (Follow-up)

during pregnancy. The exact mechanism is unclear, but genetic, hormonal, and environmental factors are likely contributory factors. Intrahepatic cholestasis typically occurs in late pregnancy, and it is characterized by intense pruritus and rash over the hands and feet. The maternal prognosis is good, although there may be an increased risk for gallstone disease, hepatic fibrosis, and cholangitis. Fetal consequences are more severe and include meconium ingestion and intrauterine demise. [ ] What hair (...) Common Pregnancy Complaints and Questions (Follow-up) Common Pregnancy Complaints and Questions: First Trimester, Second Trimester, Third Trimester Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

96. Liver Disease and Pregnancy (Diagnosis)

, and then moves centrally to the trunk and face. The pruritus persists and worsens as the pregnancy continues and resolves within 48 hours of delivery. The pruritus is often worse at night and may be so severe that it causes sleep disturbance, irritability, and psychiatric disturbances. Approximately 10%-25% of patients develop jaundice, usually 1-4 weeks after the onset of pruritus. No rash is associated with ICP. Some patients, however, may have excoriations caused by scratching. Patients may occasionally (...) handling of food. Symptoms Symptoms in pregnancy are the same as those seen in nonpregnant patients, including malaise, fatigue, nausea, vomiting, right upper quadrant pain, and pruritus, which may be more severe in pregnancy (secondary to elevated levels of estrogen). Diagnosis The diagnosis of acute hepatitis A infection is made with the detection of hepatitis A immunoglobulin M (IgM) antibodies. Intrauterine transmission with infection during the first trimester has been reported; this was diagnosed

2014 eMedicine.com

97. Common Pregnancy Complaints and Questions (Diagnosis)

during pregnancy. The exact mechanism is unclear, but genetic, hormonal, and environmental factors are likely contributory factors. Intrahepatic cholestasis typically occurs in late pregnancy, and it is characterized by intense pruritus and rash over the hands and feet. The maternal prognosis is good, although there may be an increased risk for gallstone disease, hepatic fibrosis, and cholangitis. Fetal consequences are more severe and include meconium ingestion and intrauterine demise. [ ] What hair (...) Common Pregnancy Complaints and Questions (Diagnosis) Common Pregnancy Complaints and Questions: First Trimester, Second Trimester, Third Trimester Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

98. Pruritic Urticarial Papules and Plaques of Pregnancy (Treatment)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEyMzcyNS10cmVhdG1lbnQ= processing > Polymorphic Eruption of Pregnancy Treatment & Management Updated: May 14, 2018 Author: Joseph C Pierson, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Polymorphic Eruption of Pregnancy Treatment Approach Considerations Treatment is directed at relieving the pruritus associated with polymorphic eruption of pregnancy (PEP). Topical corticosteroids are the mainstay of treatment. [ ] High-potency topical (class I or II), or even systemic (...) Pruritic Urticarial Papules and Plaques of Pregnancy (Treatment) Polymorphic Eruption of Pregnancy Treatment & Management: Approach Considerations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

99. Common Pregnancy Complaints and Questions (Treatment)

during pregnancy. The exact mechanism is unclear, but genetic, hormonal, and environmental factors are likely contributory factors. Intrahepatic cholestasis typically occurs in late pregnancy, and it is characterized by intense pruritus and rash over the hands and feet. The maternal prognosis is good, although there may be an increased risk for gallstone disease, hepatic fibrosis, and cholangitis. Fetal consequences are more severe and include meconium ingestion and intrauterine demise. [ ] What hair (...) Common Pregnancy Complaints and Questions (Treatment) Common Pregnancy Complaints and Questions: First Trimester, Second Trimester, Third Trimester Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

100. Pruritic Urticarial Papules and Plaques of Pregnancy (Overview)

of an unusual skin eruption in pregnancy can provoke anxiety, but the pruritus is the most distressing feature. The later weeks of pregnancy can be associated with many physical symptoms, and the severe itching of PEP may further debilitate and aggravate sleep loss in the weeks prior to delivery. No known systemic complications exist for affected females, and fetal mortality or morbidity do not increase. Previous Next: Patient Education The patient should understand that PEP is a benign disorder and has (...) Pruritic Urticarial Papules and Plaques of Pregnancy (Overview) Polymorphic Eruption of Pregnancy: Background, Epidemiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEyMzcyNS1vdmVydmlldw

2014 eMedicine.com

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>