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Pruritus in Pregnancy

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61. Efficacy of Calmmax Cream in the Management of Chronic Uremic Pruritus

for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: History of pruritus of >8 weeks duration. Severity score of pruritus ≥5 as defined by VAS Discontinuation of any medication with presumed antipruritic effects at least 1 week before the study (including Calmmax cream) Negative pregnancy test result for all participating women of childbearing age; Exclusion Criteria: Known allergy to Calmmax cream Any acute illness (...) Efficacy of Calmmax Cream in the Management of Chronic Uremic Pruritus Efficacy of Calmmax Cream in the Management of Chronic Uremic Pruritus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy

2014 Clinical Trials

62. Pruritus

Pruritus Pruritus (PDQ®)—Health Professional Version - National Cancer Institute Menu Search Search Search Overview Pruritus is usually an unpleasant sensation that elicits a desire to scratch, subjectively quantified by intensity, severity, location, and intractability. It may be proposed that itch is akin to pain, as both are thought to be transmitted from skin to central nervous system (CNS) through nociceptive small-caliber C nerve fibers.[ ] Perception of pruritus, much like pain (...) , is greatly altered by psychological and CNS factors, thereby accounting for the great subjective variability between individuals in perceived pruritus from the same pruritogen. Because of the subjective nature of pruritus, the lack of a precise definition, and the lack of suitable animal models, pruritus is a disorder that has not been researched adequately. For the purpose of this discussion, a focus will be placed on pruritus in the absence of a primary dermatosis, as is often encountered in patients

2012 PDQ - NCI's Comprehensive Cancer Database

63. Systematic review and meta-analysis: Ursodeoxycholic acid for intrahepatic cholestasis of pregnancy: good for the mother, not bad for the baby

Systematic review and meta-analysis Ursodeoxycholic acid for intrahepatic cholestasis of pregnancy: good for the mother, not bad for the baby Elizabeth J Carey 1 , Paula White 2 Statistics from Altmetric.com Commentary on: Bacq Y , Sentilhes L , Reyes HB , et al . Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis . Context Intrahepatic cholestasis of pregnancy (ICP) is a heritable disease of pregnancy resulting in elevation of serum bile acids, pruritus (...) Systematic review and meta-analysis: Ursodeoxycholic acid for intrahepatic cholestasis of pregnancy: good for the mother, not bad for the baby Ursodeoxycholic acid for intrahepatic cholestasis of pregnancy: good for the mother, not bad for the baby | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log

2013 Evidence-Based Medicine (Requires free registration)

64. Pruritus and Systemic Disease (Treatment)

and is effective but may only be available in intravenous form. [ ] To prevent opioid withdrawal syndrome, low starting doses should be used. These drugs should not be used in patients in need of palliative opioid treatment. Butorphanol, which antagonizes the mu receptor but agonizes the kappa receptor, has been shown to be effective in suppressing cholestatic pruritus. [ ] Ursodeoxycholic acid and S-adenosyl-L-methionine have both been reported to decrease pruritus in women with cholestasis of pregnancy (...) , Vitale G, Bertolotti M, Van Buuren HR. Oral naltrexone treatment for cholestatic pruritus: a double-blind, placebo-controlled study. Gastroenterology . 1997 Oct. 113(4):1264-9. . Bergasa NV, Alling DW, Talbot TL, Wells MC, Jones EA. Oral nalmefene therapy reduces scratching activity due to the pruritus of cholestasis: a controlled study. J Am Acad Dermatol . 1999 Sep. 41(3 Pt 1):431-4. . Palma J, Reyes H, Ribalta J, et al. Ursodeoxycholic acid in the treatment of cholestasis of pregnancy

2014 eMedicine.com

65. Pruritus and Systemic Disease (Overview)

, cholestasis of pregnancy, and end-stage liver disease of any cause. Drug-induced cholestasis may be caused by chlorpropamide, tolbutamide, phenothiazines, erythromycin, anabolic steroids, and oral contraceptives. Hematologic pruritus may be seen in association with the following conditions: Iron deficiency Polycythemia rubra vera Hypereosinophilic syndrome Essential thrombocythemia Myelodysplastic syndrome Endocrine pruritus may be seen in association with the following disorders: Hyperthyroidism (...) of leukemia. Sex The sex of the patient does not seem to be associated with pruritus in systemic diseases. Certain causes of cholestasis are more common in women than in men. These include primary biliary cirrhosis (90% of patients are women) and cholestasis of pregnancy. Primary biliary cirrhosis is thought to be an autoimmune disease that causes destruction of the small and medium bile ducts, leading to cholestasis. It most often occurs in women in the fourth or fifth decade of life, but it can occur

2014 eMedicine.com

66. Pruritus and Systemic Disease (Follow-up)

and is effective but may only be available in intravenous form. [ ] To prevent opioid withdrawal syndrome, low starting doses should be used. These drugs should not be used in patients in need of palliative opioid treatment. Butorphanol, which antagonizes the mu receptor but agonizes the kappa receptor, has been shown to be effective in suppressing cholestatic pruritus. [ ] Ursodeoxycholic acid and S-adenosyl-L-methionine have both been reported to decrease pruritus in women with cholestasis of pregnancy (...) , Vitale G, Bertolotti M, Van Buuren HR. Oral naltrexone treatment for cholestatic pruritus: a double-blind, placebo-controlled study. Gastroenterology . 1997 Oct. 113(4):1264-9. . Bergasa NV, Alling DW, Talbot TL, Wells MC, Jones EA. Oral nalmefene therapy reduces scratching activity due to the pruritus of cholestasis: a controlled study. J Am Acad Dermatol . 1999 Sep. 41(3 Pt 1):431-4. . Palma J, Reyes H, Ribalta J, et al. Ursodeoxycholic acid in the treatment of cholestasis of pregnancy

2014 eMedicine.com

67. Pruritus and Systemic Disease (Diagnosis)

, cholestasis of pregnancy, and end-stage liver disease of any cause. Drug-induced cholestasis may be caused by chlorpropamide, tolbutamide, phenothiazines, erythromycin, anabolic steroids, and oral contraceptives. Hematologic pruritus may be seen in association with the following conditions: Iron deficiency Polycythemia rubra vera Hypereosinophilic syndrome Essential thrombocythemia Myelodysplastic syndrome Endocrine pruritus may be seen in association with the following disorders: Hyperthyroidism (...) of leukemia. Sex The sex of the patient does not seem to be associated with pruritus in systemic diseases. Certain causes of cholestasis are more common in women than in men. These include primary biliary cirrhosis (90% of patients are women) and cholestasis of pregnancy. Primary biliary cirrhosis is thought to be an autoimmune disease that causes destruction of the small and medium bile ducts, leading to cholestasis. It most often occurs in women in the fourth or fifth decade of life, but it can occur

2014 eMedicine.com

68. A Comprehensive Evaluation of Steroid Metabolism in Women with Intrahepatic Cholestasis of Pregnancy (PubMed)

A Comprehensive Evaluation of Steroid Metabolism in Women with Intrahepatic Cholestasis of Pregnancy Intrahepatic cholestasis of pregnancy (ICP) is a common liver disorder, mostly occurring in the third trimester. ICP is defined as an elevation of serum bile acids, typically accompanied by pruritus and elevated activities of liver aminotransferases. ICP is caused by impaired biliary lipid secretion, in which endogenous steroids may play a key role. Although ICP is benign for the pregnant woman

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2016 PloS one

69. Evaluating the effectiveness and safety of ursodeoxycholic acid in treatment of intrahepatic cholestasis of pregnancy: A meta-analysis (a prisma-compliant study). (PubMed)

not large enough to convince obstetricians to use UDCA. We conducted a meta-analysis to evaluate the effects and safety of UDCA in patients with ICP, which included only randomized controlled trials (RCTs).Six databases were searched. The search terms were "ursodeoxycholicacid," "therapy," "management," "treatment," "intrahepatic cholestasis of pregnancy," "obstetric cholestasis," "recurrent jaundice of pregnancy," "pruritus gravidarum," "idiopathic jaundice of pregnancy," "intrahepatic jaundice (...) of pregnancy," and "icterus gravidarum."Randomized controlled trials of UDCA versus control groups (included using other medicines) among patients with ICP were included. The primary outcomes were improved pruritus scores and liver function. Secondary outcomes were the maternal and fetal outcomes in patients with ICP.Data were extracted from included RCTs. The Mantel-Haenzel random-effects model or fixed-effects model was used for meta-analysis.A total of 12 RCTs involving 662 patients were included

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2016 Medicine

70. Intrahepatic Cholestasis of Pregnancy with Severe Elevation of Bile Acids in the Setting of Acute Hepatitis C Infection (PubMed)

Intrahepatic Cholestasis of Pregnancy with Severe Elevation of Bile Acids in the Setting of Acute Hepatitis C Infection Intrahepatic cholestasis of pregnancy (ICP) is a complication of pregnancy resulting in elevation of serum bile acid levels. ICP is often associated with underlying liver disease, including hepatitis C. Bile acids in relationship to the acute infection of hepatitis C virus have not yet been delineated in the literature. A 26-year-old gravida 4 para 2103 with dichorionic (...) , diamniotic twin gestation and history of intravenous drug abuse developed ICP in the setting of acute hepatitis C infection. In addition to clinical symptoms of pruritus and right upper quadrant pain, she developed severe elevation in bile acids, 239 micromol/L, and transaminitis aspartate aminotransferase 1033 U/L, and alanine aminotransferase 448 U/L. She received ursodeoxycholic acid and antenatal testing was performed. Patient delivered vaginally at 33-week gestation following preterm rupture

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2016 Case reports in obstetrics and gynecology

71. Ursodeoxycholic Acid and S-adenosylmethionine for the Treatment of Intrahepatic Cholestasis of Pregnancy: A Meta-analysis. (PubMed)

Ursodeoxycholic Acid and S-adenosylmethionine for the Treatment of Intrahepatic Cholestasis of Pregnancy: A Meta-analysis. An optimal therapeutic strategy has not yet been identified for the pharmacological treatment of intrahepatic cholestasis of pregnancy (ICP). The aim of this study was to evaluate the efficacy and safety of ursodeoxycholic acid (UDCA) and S-adenosylmethionine (SAMe) in the treatment of ICP, both individually and in combination.A meta-analysis of all randomized controlled (...) trials (RCTs) comparing UDCA, SAMe, and combination therapy was performed. We carried out a literature search using pubmed, embase, the cochrane register of controlled trials, and the science citation index of web of science. The maternal clinical and biochemical responses, including pruritus scores, total bilirubin, total bile acids, alanine aminotransferase, and aspartate transaminase, were evaluated. Safety assessments, including preterm delivery, cesarean section, and meconium-stained amniotic

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2016 Hepatitis monthly

72. Pregnancy detecting plants used in Remo and Ijebu areas of Ogun State, Nigeria (PubMed)

Pregnancy detecting plants used in Remo and Ijebu areas of Ogun State, Nigeria Plants and plants extracts are employed in cultures for religious purposes, as beauty therapies, in the detection and management/treatment of diseases.In this study, an ethnobotanical studies of plants used in detecting pregnancy in Ijebu and Remo areas of Ogun State were carried out using semi-structured to obtain demographic data, local names of plants, the morphological parts used. Furthermore, a phytochemical (...) analysis of two of the identified plants was performed. Topical and urine tests of plants in detecting pregnancy were designed to mimic procedures used in traditional medicine for detecting pregnancy.Five plant species were identified belonging to the families Araceae, Asteraceae, Convolvulaceae, Nyctaginaceae, and Rubiaceae in the survey. The identified plants had the use value (UV) of 0.25 (Culcasia scandens), 0.17 (Ipomoea mauritiana), Boerhavia diffusa while Launea taraxacifolia and Chassalia kolly

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2016 Journal of intercultural ethnopharmacology

73. Different antibiotic regimens for treating asymptomatic bacteriuria in pregnancy. (PubMed)

Different antibiotic regimens for treating asymptomatic bacteriuria in pregnancy. Asymptomatic bacteriuria occurs in 5% to 10% of pregnancies and, if left untreated, can lead to serious complications.To assess which antibiotic is most effective and least harmful as initial treatment for asymptomatic bacteriuria in pregnancy.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (March 2010) and reference lists of retrieved studies.Randomized controlled trials comparing two (...) (risk ratio (RR) 1.36, 95% confidence interval (CI) 0.24 to 7.75), shift to other antibiotics (RR 0.08, 95% CI 0.00 to 1.45), or in allergy or pruritus (RR 2.73, 95% CI 0.11 to 65.24). A comparison of seven-day courses of 400 mg pivmecillinam versus 500 mg ampicillin, both given four times daily, showed no significant difference in persistent infection at two weeks or recurrent infection, but there was an increase in vomiting (RR 4.57, 95% CI 1.40 to 14.90) and women were more likely to stop

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2010 Cochrane

74. Pruritus in cholestasis - facts and fiction. (PubMed)

Pruritus in cholestasis - facts and fiction. Pruritus is a common symptom in patients with cholestatic liver diseases such as primary biliary cirrhosis, primary sclerosing cholangitis, intrahepatic cholestasis of pregnancy, or hereditary pediatric cholestatic disorders and may accompany, although less frequently, many other liver diseases. Recent findings indicate that lysophosphatidic acid (LPA), a potent neuronal activator, and autotaxin (ATX; ectonucleotide pyrophosphatase/phosphodiesterase (...) 2), the enzyme which forms LPA, may form a key element of the long-sought pruritogenic signaling cascade in cholestatic patients suffering from itch. Serum ATX, but no other pruritogen candidate studied so far, correlates with pruritus intensity and responds to therapeutic interventions. In this comprehensive review, we provide a short update on actual insights in signal transmission related to pruritus and discuss pruritogen candidates in cholestasis. We also summarize evidence-based

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2013 Hepatology

75. Proof of Concept of VLY-686 in Subjects With Treatment-Resistant Pruritus Associated With Atopic Dermatitis

Proof of Concept of VLY-686 in Subjects With Treatment-Resistant Pruritus Associated With Atopic Dermatitis Proof of Concept of VLY-686 in Subjects With Treatment-Resistant Pruritus Associated With Atopic Dermatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Proof of Concept of VLY-686 in Subjects With Treatment-Resistant Pruritus Associated With Atopic Dermatitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02004041 Recruitment Status : Completed First Posted : December 6, 2013 Last Update

2013 Clinical Trials

76. Itch in pregnancy

NICE quality standards No NICE quality standards were found during the review of this topic. Background information Background information Definition What is it? Itch (also known as pruritus) is described as an unpleasant sensation that triggers a desire to scratch [ ]. Causes of itch What causes it? Itch in pregnancy may be caused by: A pre-existing or coincidental condition — see the CKS topic on for more information. A condition that is specific to pregnancy. The most common (...) of these are: — which does not present with a rash. , , and — all of which present with a rash. [ ; ; ] Obstetric cholestasis Obstetric cholestasis Obstetric cholestasis is also known as 'intrahepatic cholestasis of pregnancy', 'jaundice of pregnancy', and 'pruritus gravidarum'. It is the most common cause of itch that presents without a rash in pregnancy. The itch is caused by the deposition of bile salts in the skin that results from cholestasis (impaired bile flow). The cause of the cholestasis is not fully

2015 NICE Clinical Knowledge Summaries

77. Effect of Neurokinin-1 Receptor (NK1R) Antagonism on Pruritus in Patients With Sezary Syndrome

for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Known Sezary Syndrome Pruritus uncontrolled by conventional treatment. Baseline visual analogue scale > 4. Age 18 through 80 years of age. Stable medication regimens for both Sezary Syndrome and pruritus for 3 months prior to study participation. Exclusion Criteria: Known hepatic impairment (defined as liver function tests >3 times the upper limit of normal). Pregnancy (all women of child-bearing potential will undergo urine beta (...) Effect of Neurokinin-1 Receptor (NK1R) Antagonism on Pruritus in Patients With Sezary Syndrome Effect of Neurokinin-1 Receptor (NK1R) Antagonism on Pruritus in Patients With Sezary Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2012 Clinical Trials

78. Cholestasis associated Pruritus

VI. Management (or if limited) Has also been used in of pregnancy Used in primary biliary (intense itch) May be indicated in refractory cases receptor antagonist IV PO VII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Cholestasis associated Pruritus." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Dermatology About (...) Cholestasis associated Pruritus Cholestasis associated Pruritus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cholestasis associated

2015 FP Notebook

79. Pruritus Causes

water contact (follows warm bath) Pregnancy (See ) Prurigo of Pregnancy or ( ) Pruritic of Pregnancy Medications , , B s Ointments with high concentrations of inert oil s (especially via spinal administration) Allergen or irritant exposure (e.g. ) Heat exposure: ( ) Cat exposure glass exposure ( glass Dermatitis) VI. Causes: Age-related Pruritus Children s Elderly VII. References See Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term (...) Pruritus Causes Pruritus Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pruritus Causes Pruritus Causes Aka: Pruritus Causes

2015 FP Notebook

80. Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: A prospective population-based case-control study. (PubMed)

Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: A prospective population-based case-control study. Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease, characterized by maternal pruritus and raised serum bile acids. Our objectives were to describe the epidemiology and pregnancy complications associated with severe ICP and to test the hypothesis that adverse perinatal outcomes are increased in these women. A prospective (...) population-based case-control study with national coverage was undertaken using the UK Obstetric Surveillance System (UKOSS). Control data for comparison were obtained from women with healthy pregnancy outcome through UKOSS (n = 2,232), St Mary's Maternity Information System (n = 554,319), and Office for National Statistics (n = 668,195). The main outcome measures investigated were preterm delivery, stillbirth, and neonatal unit admission. In all, 713 confirmed cases of severe ICP were identified, giving

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2013 Hepatology

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