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Pruritus in Pregnancy

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41. Dyspepsia - pregnancy-associated

Dyspepsia - pregnancy-associated Dyspepsia - pregnancy-associated - NICE CKS Share Dyspepsia - pregnancy-associated: Summary Dyspepsia in pregnancy is commonly due to gastro-oesophageal reflux, thought to involve a combination of mechanical and hormonal factors. Between 30% and 80% of women suffer from dyspepsia at some time during their pregnancy, with symptoms starting at any stage of pregnancy. There appears to be an increased risk of symptoms in women who have had symptoms of gastro (...) -oesophageal reflux prior to pregnancy, women of increasing gestational age, and women who have had a previous pregnancy. Once gastro-oesophageal reflux symptoms have developed, there is a high likelihood that they will persist throughout the pregnancy. However, in most women symptoms will disappear shortly after delivery. Symptoms include heartburn and acid reflux. Investigations are generally not necessary. Lifestyle advice should be offered as first-line management. Dyspepsia in pregnancy can usually

2017 NICE Clinical Knowledge Summaries

42. Intrahepatic Cholestasis of Pregnancy: A Review of Diagnosis and Management. (PubMed)

Intrahepatic Cholestasis of Pregnancy: A Review of Diagnosis and Management. Intrahepatic cholestasis of pregnancy (ICP) complicates approximately 0.2% to 2% of pregnancies and can lead to increased fetal risks in pregnancy.This review aims to increase the knowledge of women's health care providers regarding the diagnosis, management, and fetal risks associated with ICP.The diagnosis of ICP is based on symptoms of pruritus that typically include the palms and soles, as well as elevated bile (...) pruritus symptoms, as well as biochemical tests, but no treatment has been shown to definitively improve fetal outcomes.Providers should be aware of the signs and symptoms of ICP and provide accurate diagnosis and management of affected women. Women with a diagnosis of ICP should be treated with ursodeoxycholic acid to improve maternal symptoms. Given the increased risk of stillbirth in the setting of ICP, delivery may be considered at 37 weeks' gestation.

2018 Obstetrical & Gynecological Survey

43. Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES) (PubMed)

Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES) Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder specific to pregnancy and presents with maternal pruritus, raised concentrations of serum bile acids and abnormal liver function tests. ICP is associated with increased rates of spontaneous and iatrogenic preterm labour, fetal (...) hypoxia, meconium-stained amniotic fluid and intrauterine death. Some clinicians treat ICP with ursodeoxycholic acid (UDCA) to improve maternal pruritus and biochemical abnormalities. However, there are currently no data to support the use of UDCA to improve pregnancy outcome as none of the trials performed to date have been powered to address this question.The PITCHES trial is a triple-masked, placebo-controlled randomised trial, to evaluate UDCA versus placebo in women with ICP between 20 + 0 to 40

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2018 Trials

44. Pruritus of Pregnancy: A Symptom of Hepatic Dysfunction, with a Report of Two Cases (PubMed)

Pruritus of Pregnancy: A Symptom of Hepatic Dysfunction, with a Report of Two Cases 13777461 1998 11 01 2018 12 02 0008-4409 85 1961 Sep 23 Canadian Medical Association journal Can Med Assoc J Pruritus of pregnancy, a symptom of hepatic dysfunction, with a report of two cases. 724-6 TOPP J R JR CHARLES B B eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 OM Female Humans Liver Diseases Pregnancy Pregnancy Complications Pruritus PREGNANCY/complications PRURITUS/in pregnancy 1961 9 23

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1961 Canadian Medical Association Journal

45. On the Occurrence of an Unusual form of Pruritus during Pregnancy (PubMed)

On the Occurrence of an Unusual form of Pruritus during Pregnancy 20746764 2011 03 29 2011 03 29 0007-1447 2 612 1872 Sep 21 British medical journal Br Med J On the Occurrence of an Unusual form of Pruritus during Pregnancy. 323-4 Page D D eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1872 9 21 0 0 1872 9 21 0 1 ppublish 20746764 PMC2297129

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1872 British medical journal

46. Aprepitant vs. Desloratadine in EGFR-TKIs Related Pruritus Treatment

pruritus (VAS score ≥ 4) first occur after EGFR TKIs treatment Life expectancy ≥ 3 months Orally drug administration with no difficulty pregnancy test negative in 7 days for women of child-bearing age; willing to take contraception measures. Signed informed consent form (ICF) Exclusion Criteria: Systemically treatment with Neurokinin-1 (NK-1) receptor inhibitors, antihistamines drugs, antibiotics, cortical hormone therapy, antiepileptic drugs, immunosuppressive agents or other drugs might affect (...) Aprepitant vs. Desloratadine in EGFR-TKIs Related Pruritus Treatment Aprepitant vs. Desloratadine in EGFR-TKIs Related Pruritus Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Aprepitant vs

2015 Clinical Trials

47. Efficacy of Laser Acupuncture on Pruritus in Patients With Chronic Kidney Disease Undergoing Hemodialysis

Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Age>20y/o, ESRD patient, pruritus symptoms persist longer than 4 weeks Exclusion Criteria: immunosupression agents use, undergo chemotherapy drug abuser pregnancy women patient with psychiological disorder arrhythemia, pacemaker device use local skin infection over laser acupuncture site patient allergy to laser acupuncture treament Contacts and Locations Go to Information (...) Efficacy of Laser Acupuncture on Pruritus in Patients With Chronic Kidney Disease Undergoing Hemodialysis Efficacy of Laser Acupuncture on Pruritus in Patients With Chronic Kidney Disease Undergoing Hemodialysis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2015 Clinical Trials

48. Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis

morphine: a systematic review and meta-analysis. Anesthesia and Analgesia 2009; 109(1): 174-182 PubMedID DOI Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Cesarean Section /adverse effects; Female; Humans; Injections, Spinal; Morphine /administration & Postoperative Nausea and Vomiting /chemically induced /drug therapy /prevention & Pregnancy; Pruritus /drug therapy /prevention & Receptors, Serotonin, 5-HT3 /physiology; Serotonin 5-HT3 Receptor Antagonists; Serotonin (...) Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting

2009 DARE.

49. Secukinumab Study in PSOriasis Exploring pruRITUS Intensity and Lesional Biomarkers

Secukinumab Study in PSOriasis Exploring pruRITUS Intensity and Lesional Biomarkers Secukinumab Study in PSOriasis Exploring pruRITUS Intensity and Lesional Biomarkers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Secukinumab Study in PSOriasis Exploring pruRITUS Intensity and Lesional Biomarkers (PSORITUS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02362789 Recruitment Status : Completed First Posted : February 13, 2015 Results First Posted : December 28, 2018 Last Update Posted : December 28

2015 Clinical Trials

50. Phase 1 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus

Phase 1 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus Phase 1 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Phase 1 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02373215 Recruitment Status : Completed First Posted : February 26, 2015 Last Update Posted : February 26, 2015 Sponsor: Trevi Therapeutics

2015 Clinical Trials

51. [Meta-analysis of Yinzhihuang oral liquid in treatment of intrahepatic cholestasis of pregnancy]. (PubMed)

[Meta-analysis of Yinzhihuang oral liquid in treatment of intrahepatic cholestasis of pregnancy]. To systematically review the clinical efficacy and safety of Yinzhihuang oral liquid in the treatment of intrahepatic cholestasis of pregnancy(ICP). Literatures published by June 2016 were searched in databases, such as Medline, Pubmed, Cochrane Library, China National Knowledge Infrastructure(CNKI), Chinese Scientific Journals Full-text Database(VIP), Chinese biomedical literature database(CBM (...) ), and Wanfang Database. Randomized controlled trials(RCT) of Yinzhihuang oral liquid were collected according to the inclusion criteria, and the methodological quality of selected literatures was evaluated. The Meta-analysis was conducted by using RevMan 5.3 software. A total of 7 RCTs involving 711 patients were included. The results of Meta-analysis showed that, compared with control group, Yinzhihuang oral liquid significantly alleviated pruritus symptoms[MD=-0.68, 95%CI(-0.95,-041), P<0.000 01], reduced

2017 Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

52. Intrahepatic cholestasis of pregnancy or azithromycin-induced intrahepatic cholestasis: A case report. (PubMed)

Intrahepatic cholestasis of pregnancy or azithromycin-induced intrahepatic cholestasis: A case report. Azithromycin-induced liver injury has been rarely reported in adult individuals, let alone in a pregnant woman. Here, we describe the clinical features and outcomes of azithromycin-induced liver injury in a pregnant woman.A 30-year-old pregnant woman presented with generalized pruritus and elevated serum bile acid level (123.6 μmol/L) on day 4 of azithromycin administration. A diagnosis (...) of intrahepatic cholestasis of pregnancy was made, and cesarean section was performed immediately. Interestingly, the alanine aminotransferase level (ALT) reached 211.2 U/L on day 9 after azithromycin administration.Therefore, drug-induced intrahepatic cholestasis was considered.(1) Azithromycin withdrawal after the patient hospitalized. (2) Termination of pregnancy by cesarean section was performed inmmediately to protect the fetus. (3) Silymarin capsules and bifendate are used to protect the liver after

2017 Medicine

53. Complications, Symptoms, Quality of Life, and Pregnancy in Cholestatic Liver Disease. (PubMed)

) and symptoms (eg pruritus and fatigue), can significantly impair an array of domains of HRQOL. Here we review these impactful clinical aspects of PSC and PBC as well as the topics of fertility and pregnancy.© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. (...) Complications, Symptoms, Quality of Life, and Pregnancy in Cholestatic Liver Disease. Cholestatic liver diseases (CLDs) encompass a variety of disorders of bile formation and/or flow which generally result in progressive hepatobiliary injury and ultimately end-stage liver disease. Many patients with CLD are diagnosed between the ages of 20-50 years, a particularly productive period of life professionally, biologically and in other respects; it is not surprising, thus, that CLD is often

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2017 Liver International

54. Prospective Cohort Study of HIV and Zika in Infants and Pregnancy

regulations). Age 15 years or older at enrollment. Confirmation of pregnancy by βhCG measurement in blood or urine or fetal ultrasound (US) heart tones present. Based on pregnancy calculator or fetal US: Confirmation of being at <18 weeks gestational age (GA) of pregnancy or at any GA if presents with acute ZIKV-like symptoms (i.e., fever, rash, arthralgia, myalgia, pruritus, headache, eye pain, and conjunctivitis) and has laboratory-confirmed ZIKV infection by ZIKV RNA detection. Plans on remaining (...) Prospective Cohort Study of HIV and Zika in Infants and Pregnancy Prospective Cohort Study of HIV and Zika in Infants and Pregnancy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prospective Cohort Study

2017 Clinical Trials

55. Pruritic Urticarial Papules and Plaques of Pregnancy Occurring Postpartum Treated with Intramuscular Injection of Autologous Whole Blood (PubMed)

Pruritic Urticarial Papules and Plaques of Pregnancy Occurring Postpartum Treated with Intramuscular Injection of Autologous Whole Blood Pruritic urticarial papules and plaques of pregnancy (PUPPP) is one of the most common diseases associated with pregnancy. In most cases, the skin lesions develop in the third trimester of primigravidas. There are no systemic alterations seen in PUPPP; however, most patients report severe pruritus. A 34-year-old woman presented 1 week postpartum with typical (...) clinical features of PUPPP. The patient showed good response to intramuscular injection of autologous whole blood with no adverse effects to the patient or her baby. Presentation of PUPPP in the postpartum period is rare. Conservative management with topical corticosteroids and oral antihistamines is commonly used to relieve pruritus. In severe cases, skin lesions and symptoms are controlled with a brief course of systemic corticosteroids. Investigation of new treatment options has been limited

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2017 Case reports in dermatology

56. A Screening Study on Dermatoses in Pregnancy (PubMed)

examination was done. Results were tabulated and analysed. Statistical analysis was done by Fisher's exact test and Chi square test.Physiological skin changes were seen in 94.8% of cases, with pigmentary changes being more common (90.8%). Specific dermatoses of pregnancy were observed in 14% of cases with pruritus gravidarum being the most common (10.4%). Prevalence of infection was found to 30.8% with fungal infection being the most common (23.8%). Exacerbations of systemic lupus erythematosus (...) A Screening Study on Dermatoses in Pregnancy Pregnancy produces many cutaneous changes, some of which are specifically related to pregnancy (dermatoses of pregnancy), some are modifiable by pregnancy and others that are common are named physiologic. These physiologic skin changes, usually do not impair the health of the mother or the fetus but some of them can be cosmetically significant and of importance to the dermatologist.The present study was undertaken to find out the prevalence

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2017 Journal of clinical and diagnostic research : JCDR

57. Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy (PubMed)

Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy Intrahepatic cholestasis of pregnancy is seldom associated with significant vitamin K deficiency. We report a case of a 16-year-old primigravid patient at 24 weeks and 3 days of gestation who presented with pruritus, hematuria, and preterm labor. Laboratory work-up showed severe coagulopathy with Prothrombin Time (PT) of 117.8 seconds, International Normalized Ratio (INR) of 10.34, and elevated (...) transaminases suggestive of intrahepatic cholestasis of pregnancy. Her serum vitamin K level was undetectable (<0.1 nMol/L). Initial therapy consisted of intramuscular replacement of vitamin K and administration of fresh frozen plasma. Her hematuria and preterm labor resolved and she was discharged. She presented in active labor and delivered at 27 weeks and 1 day. Her bile acids (93 μ/L) and INR (2.32) had worsened. She delivered a male infant, 1150 grams with Apgar scores 7 and 9. The newborn received 0.5

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2017 Case reports in obstetrics and gynecology

58. Dubin–Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report (PubMed)

Dubin–Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy are rare chronic liver disorders. Dubin-Johnson syndrome may manifest as conjugated hyperbilirubinemia, darkly pigmented liver, presence of abnormal pigment in the parenchyma of hepatocytes and abnormal distribution of the coproporphyrin isomers I and III in the urine. Intrahepatic cholestatic jaundice of pregnancy presents (...) as pruritus, abnormal liver biochemistry and increased serum bile acids.A Sri Lankan girl presented with recurrent episodes of jaundice. She had conjugated hyperbilirubinaemia with diffuse, coarse brown pigments in the hepatocytes. Urine coproporphyrin examination suggested Dubin-Johnson syndrome. Genetic studies confirmed missense homozygous variant p.Trp709Arg in the ATP-binding cassette sub-family C member 2 gene ABCC2 that encodes the Multidrug resistance-associated protein 2 that causes Dubin-Johnson

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2017 BMC research notes

59. An expanded role for heterozygous mutations of ABCB4, ABCB11, ATP8B1, ABCC2 and TJP2 in intrahepatic cholestasis of pregnancy (PubMed)

An expanded role for heterozygous mutations of ABCB4, ABCB11, ATP8B1, ABCC2 and TJP2 in intrahepatic cholestasis of pregnancy Intrahepatic cholestasis of pregnancy (ICP) affects 1/140 UK pregnancies; with pruritus, hepatic impairment and elevated serum bile acids. Severe disease is complicated by spontaneous preterm delivery and stillbirth. Previous studies have reported mutations in hepatocellular transporters (ABCB4, ABCB11). High throughput sequencing in 147 patients was performed

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2017 Scientific reports

60. Efficacy and Safety Study of PAC-14028 Cream in Dermal Pruritus

Eczema or dry skin on the study drug application site Women of childbearing potential should have a negative urine pregnancy test at screening and agree to employ an effective method of birth control (surgical sterilization or oral contraceptives, barrier method with spermicides, intrauterine device, etc.) during the study period. Voluntarily signed written informed consent forms for study participation. Exclusion Criteria: Pruritus due to other medical (liver disease, renal failure, etc.), psychotic (...) Efficacy and Safety Study of PAC-14028 Cream in Dermal Pruritus Evaluation of the Antipruritic Effect of PAC-14028 Cream in Skin Pruritus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation

2014 Clinical Trials

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