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Pruritus in Pregnancy

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41. A Study of SK-1405 in Hemodialysis Patients With Uremic Pruritus

A Study of SK-1405 in Hemodialysis Patients With Uremic Pruritus A Study of SK-1405 in Hemodialysis Patients With Uremic Pruritus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of SK-1405 (...) in Hemodialysis Patients With Uremic Pruritus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03218501 Recruitment Status : Completed First Posted : July 14, 2017 Last Update Posted : March 8, 2019 Sponsor: Sanwa Kagaku Kenkyusho Co., Ltd. Information provided by (Responsible Party): Sanwa Kagaku Kenkyusho Co

2017 Clinical Trials

42. Dyspepsia - pregnancy-associated

age, with 30–80% of women suffering from dyspepsia at some time during their pregnancy [ ; ; ; ; ]. A prospective longitudinal cohort study of the evolution of GORD symptoms during pregnancy found that [ ]: Of pregnant women, 12.5% had heartburn at least once a week in the first trimester, 21.5% in the second trimester, and 35.3% in the third trimester. Daily heartburn occurred in around 10% of women in the third trimester. In the third trimester, 40.7% of women experienced regurgitation at least (...) once a week (compared with 3.6% of non-pregnant women). Risk factors What are the risk factors? The following risk factors have been associated with gastro-oesophageal reflux symptoms in pregnancy: Symptoms of gastro-oesophageal reflux prior to pregnancy. Increasing gestational age. Parity. The evidence for the following risk factors is less certain: Pre-pregnancy body mass index (BMI). Weight gain during pregnancy. Maternal age. [ ; ; ] Complications What are the complications? Symptoms usually

2017 NICE Clinical Knowledge Summaries

43. Intrahepatic Cholestasis of Pregnancy: A Review of Diagnosis and Management. (Abstract)

Intrahepatic Cholestasis of Pregnancy: A Review of Diagnosis and Management. Intrahepatic cholestasis of pregnancy (ICP) complicates approximately 0.2% to 2% of pregnancies and can lead to increased fetal risks in pregnancy.This review aims to increase the knowledge of women's health care providers regarding the diagnosis, management, and fetal risks associated with ICP.The diagnosis of ICP is based on symptoms of pruritus that typically include the palms and soles, as well as elevated bile (...) pruritus symptoms, as well as biochemical tests, but no treatment has been shown to definitively improve fetal outcomes.Providers should be aware of the signs and symptoms of ICP and provide accurate diagnosis and management of affected women. Women with a diagnosis of ICP should be treated with ursodeoxycholic acid to improve maternal symptoms. Given the increased risk of stillbirth in the setting of ICP, delivery may be considered at 37 weeks' gestation.

2018 Obstetrical & Gynecological Survey

44. Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES) (Full text)

Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES) Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder specific to pregnancy and presents with maternal pruritus, raised concentrations of serum bile acids and abnormal liver function tests. ICP is associated with increased rates of spontaneous and iatrogenic preterm labour, fetal (...) hypoxia, meconium-stained amniotic fluid and intrauterine death. Some clinicians treat ICP with ursodeoxycholic acid (UDCA) to improve maternal pruritus and biochemical abnormalities. However, there are currently no data to support the use of UDCA to improve pregnancy outcome as none of the trials performed to date have been powered to address this question.The PITCHES trial is a triple-masked, placebo-controlled randomised trial, to evaluate UDCA versus placebo in women with ICP between 20 + 0 to 40

2018 Trials PubMed abstract

45. Pruritus (PDQ®): Health Professional Version

Pruritus (PDQ®): Health Professional Version Pruritus (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf Warning: The NCBI web site requires JavaScript to function. Search database Search term Search NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): ; 2002-. Search term Pruritus (PDQ® (...) ) Health Professional Version PDQ Supportive and Palliative Care Editorial Board . Published online: August 13, 2019. This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the pathophysiology and treatment of pruritus. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions. This summary is reviewed

2016 PDQ - NCI's Comprehensive Cancer Database

46. Cholestasis associated Pruritus

VI. Management (or if limited) Has also been used in of pregnancy Used in primary biliary (intense itch) May be indicated in refractory cases receptor antagonist IV PO VII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Cholestasis associated Pruritus." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Dermatology About (...) Cholestasis associated Pruritus Cholestasis associated Pruritus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cholestasis associated

2018 FP Notebook

47. Pruritus Causes

water contact (follows warm bath) Pregnancy (See ) Prurigo of Pregnancy or ( ) Pruritic of Pregnancy Medications , , B s Ointments with high concentrations of inert oil s (especially via spinal administration) Allergen or irritant exposure (e.g. ) Heat exposure: ( ) Cat exposure glass exposure ( glass Dermatitis) VI. Causes: Age-related Pruritus Children s Elderly VII. References See Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term (...) Pruritus Causes Pruritus Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pruritus Causes Pruritus Causes Aka: Pruritus Causes

2018 FP Notebook

48. Pruritus in Pregnancy

Pruritus in Pregnancy Pruritus in Pregnancy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pruritus in Pregnancy Pruritus (...) in Pregnancy Aka: Pruritus in Pregnancy , Pregnancy Related Pruritus , Pruritus gravidarum , Prurigo gravidarum II. Causes See Common, intense involving May spread to thighs, buttocks, s and arms Prurigo of Pregnancy (Common) Onset in second-half of pregnancy s and s over arms and Associated with or (uncommon) Autoimmune disorder with association Occurs in second-half of pregnancy s and bullae form on , extremities (Common) No in mild form (Prurigo gravidarum) Trunk and extremity itching without rash

2015 FP Notebook

49. Pruritus ani

, the potential risk of harms to the pregnant woman and/or the fetus or infant is likely to be less with simple, soothing products than with those containing corticosteroid (which are generally not recommended by the manufacturers for use during pregnancy due to inadequate safety evidence). [ ; ] Chlorphenamine Chlorphenamine Dose What dose of chlorphenamine should I prescribe? The recommended oral doses of chlorphenamine are: Children aged 1 month–2 years: 1 mg twice daily. Children aged 2–6 years: 1 mg (...) or glaucoma. Pyloroduodenal obstruction. Epilepsy (may reduce seizure threshold). Asthma, bronchitis, or bronchiectasis. Children and elderly people (as they are more susceptible to adverse effects). Pregnant or breastfeeding women: The manufacturer of chlorphenamine advises avoiding its use during pregnancy. However, the UK Teratology Information Service (UKTIS) bumps patient information leaflets on chlorphenamine states that there is currently no evidence that chlorphenamine is harmful to a fetus

2016 NICE Clinical Knowledge Summaries

50. Systematic review and meta-analysis: Ursodeoxycholic acid for intrahepatic cholestasis of pregnancy: good for the mother, not bad for the baby

Systematic review and meta-analysis Ursodeoxycholic acid for intrahepatic cholestasis of pregnancy: good for the mother, not bad for the baby Elizabeth J Carey 1 , Paula White 2 Statistics from Altmetric.com Commentary on: Bacq Y , Sentilhes L , Reyes HB , et al . Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis . Context Intrahepatic cholestasis of pregnancy (ICP) is a heritable disease of pregnancy resulting in elevation of serum bile acids, pruritus (...) Systematic review and meta-analysis: Ursodeoxycholic acid for intrahepatic cholestasis of pregnancy: good for the mother, not bad for the baby Ursodeoxycholic acid for intrahepatic cholestasis of pregnancy: good for the mother, not bad for the baby | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log

2013 Evidence-Based Medicine

51. Pruritus of Pregnancy: A Symptom of Hepatic Dysfunction, with a Report of Two Cases (Full text)

Pruritus of Pregnancy: A Symptom of Hepatic Dysfunction, with a Report of Two Cases 13777461 1998 11 01 2018 12 02 0008-4409 85 1961 Sep 23 Canadian Medical Association journal Can Med Assoc J Pruritus of pregnancy, a symptom of hepatic dysfunction, with a report of two cases. 724-6 TOPP J R JR CHARLES B B eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 OM Female Humans Liver Diseases Pregnancy Pregnancy Complications Pruritus PREGNANCY/complications PRURITUS/in pregnancy 1961 9 23

1961 Canadian Medical Association Journal PubMed abstract

52. On the Occurrence of an Unusual form of Pruritus during Pregnancy (Full text)

On the Occurrence of an Unusual form of Pruritus during Pregnancy 20746764 2011 03 29 2011 03 29 0007-1447 2 612 1872 Sep 21 British medical journal Br Med J On the Occurrence of an Unusual form of Pruritus during Pregnancy. 323-4 Page D D eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1872 9 21 0 0 1872 9 21 0 1 ppublish 20746764 PMC2297129

1872 British medical journal PubMed abstract

53. Complications, Symptoms, Quality of Life, and Pregnancy in Cholestatic Liver Disease. (Full text)

) and symptoms (eg pruritus and fatigue), can significantly impair an array of domains of HRQOL. Here we review these impactful clinical aspects of PSC and PBC as well as the topics of fertility and pregnancy.© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. (...) Complications, Symptoms, Quality of Life, and Pregnancy in Cholestatic Liver Disease. Cholestatic liver diseases (CLDs) encompass a variety of disorders of bile formation and/or flow which generally result in progressive hepatobiliary injury and ultimately end-stage liver disease. Many patients with CLD are diagnosed between the ages of 20-50 years, a particularly productive period of life professionally, biologically and in other respects; it is not surprising, thus, that CLD is often

2017 Liver International PubMed abstract

54. Intrahepatic cholestasis of pregnancy or azithromycin-induced intrahepatic cholestasis: A case report. (Full text)

Intrahepatic cholestasis of pregnancy or azithromycin-induced intrahepatic cholestasis: A case report. Azithromycin-induced liver injury has been rarely reported in adult individuals, let alone in a pregnant woman. Here, we describe the clinical features and outcomes of azithromycin-induced liver injury in a pregnant woman.A 30-year-old pregnant woman presented with generalized pruritus and elevated serum bile acid level (123.6 μmol/L) on day 4 of azithromycin administration. A diagnosis (...) of intrahepatic cholestasis of pregnancy was made, and cesarean section was performed immediately. Interestingly, the alanine aminotransferase level (ALT) reached 211.2 U/L on day 9 after azithromycin administration.Therefore, drug-induced intrahepatic cholestasis was considered.(1) Azithromycin withdrawal after the patient hospitalized. (2) Termination of pregnancy by cesarean section was performed inmmediately to protect the fetus. (3) Silymarin capsules and bifendate are used to protect the liver after

2017 Medicine PubMed abstract

55. A Screening Study on Dermatoses in Pregnancy (Full text)

of the physiological and pathological skin changes in pregnancy, and to correlate the prevalence of the major cutaneous changes and diseases in relation to different trimesters of pregnancy and with gravidity.A cross-sectional study was conducted during the period of August 2008 to August 2010. Ethical clearance was sought from Institutional Ethical Committee. Five hundred pregnant women were randomly selected, irrespective of the duration of pregnancy and gravidity. Detailed history and complete dermatological (...) examination was done. Results were tabulated and analysed. Statistical analysis was done by Fisher's exact test and Chi square test.Physiological skin changes were seen in 94.8% of cases, with pigmentary changes being more common (90.8%). Specific dermatoses of pregnancy were observed in 14% of cases with pruritus gravidarum being the most common (10.4%). Prevalence of infection was found to 30.8% with fungal infection being the most common (23.8%). Exacerbations of systemic lupus erythematosus

2017 Journal of clinical and diagnostic research : JCDR PubMed abstract

56. Dubin–Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report (Full text)

Dubin–Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy are rare chronic liver disorders. Dubin-Johnson syndrome may manifest as conjugated hyperbilirubinemia, darkly pigmented liver, presence of abnormal pigment in the parenchyma of hepatocytes and abnormal distribution of the coproporphyrin isomers I and III in the urine. Intrahepatic cholestatic jaundice of pregnancy presents (...) as pruritus, abnormal liver biochemistry and increased serum bile acids.A Sri Lankan girl presented with recurrent episodes of jaundice. She had conjugated hyperbilirubinaemia with diffuse, coarse brown pigments in the hepatocytes. Urine coproporphyrin examination suggested Dubin-Johnson syndrome. Genetic studies confirmed missense homozygous variant p.Trp709Arg in the ATP-binding cassette sub-family C member 2 gene ABCC2 that encodes the Multidrug resistance-associated protein 2 that causes Dubin-Johnson

2017 BMC research notes PubMed abstract

57. An expanded role for heterozygous mutations of ABCB4, ABCB11, ATP8B1, ABCC2 and TJP2 in intrahepatic cholestasis of pregnancy (Full text)

An expanded role for heterozygous mutations of ABCB4, ABCB11, ATP8B1, ABCC2 and TJP2 in intrahepatic cholestasis of pregnancy Intrahepatic cholestasis of pregnancy (ICP) affects 1/140 UK pregnancies; with pruritus, hepatic impairment and elevated serum bile acids. Severe disease is complicated by spontaneous preterm delivery and stillbirth. Previous studies have reported mutations in hepatocellular transporters (ABCB4, ABCB11). High throughput sequencing in 147 patients was performed

2017 Scientific reports PubMed abstract

58. Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy (Full text)

Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy Intrahepatic cholestasis of pregnancy is seldom associated with significant vitamin K deficiency. We report a case of a 16-year-old primigravid patient at 24 weeks and 3 days of gestation who presented with pruritus, hematuria, and preterm labor. Laboratory work-up showed severe coagulopathy with Prothrombin Time (PT) of 117.8 seconds, International Normalized Ratio (INR) of 10.34, and elevated (...) transaminases suggestive of intrahepatic cholestasis of pregnancy. Her serum vitamin K level was undetectable (<0.1 nMol/L). Initial therapy consisted of intramuscular replacement of vitamin K and administration of fresh frozen plasma. Her hematuria and preterm labor resolved and she was discharged. She presented in active labor and delivered at 27 weeks and 1 day. Her bile acids (93 μ/L) and INR (2.32) had worsened. She delivered a male infant, 1150 grams with Apgar scores 7 and 9. The newborn received 0.5

2017 Case reports in obstetrics and gynecology PubMed abstract

59. Pruritic Urticarial Papules and Plaques of Pregnancy Occurring Postpartum Treated with Intramuscular Injection of Autologous Whole Blood (Full text)

Pruritic Urticarial Papules and Plaques of Pregnancy Occurring Postpartum Treated with Intramuscular Injection of Autologous Whole Blood Pruritic urticarial papules and plaques of pregnancy (PUPPP) is one of the most common diseases associated with pregnancy. In most cases, the skin lesions develop in the third trimester of primigravidas. There are no systemic alterations seen in PUPPP; however, most patients report severe pruritus. A 34-year-old woman presented 1 week postpartum with typical (...) clinical features of PUPPP. The patient showed good response to intramuscular injection of autologous whole blood with no adverse effects to the patient or her baby. Presentation of PUPPP in the postpartum period is rare. Conservative management with topical corticosteroids and oral antihistamines is commonly used to relieve pruritus. In severe cases, skin lesions and symptoms are controlled with a brief course of systemic corticosteroids. Investigation of new treatment options has been limited

2017 Case reports in dermatology PubMed abstract

60. Prospective Cohort Study of HIV and Zika in Infants and Pregnancy

in the continental United States (U.S.), Puerto Rico (P.R.) and Brazil. Condition or disease HIV Zika Virus Pregnant Women Detailed Description: This is a two-phase prospective international cohort study of pregnant women and their infants from those pregnancies whose goals are to compare the incidence of ZIKV infection among pregnant women with and without HIV infection and to determine the risk of adverse maternal and child outcomes associated with ZIKV/HIV co-infection across clinical sites in the continental (...) U.S., P.R. and Brazil. Phase I will enroll pregnant women/infant pairs who are: (1) infected with HIV only; (2) infected with ZIKV only; (3) infected with HIV and ZIKV; and (4) not infected with HIV or ZIKV. Phase I will assess the feasibility of enrolling a total of 200 pregnant women/infant pairs within a year, with a target of 150 HIV-infected women, 50 HIV-uninfected women from the continental U.S. sites only, and a minimum of 20 who are co-infected with HIV and ZIKV by the end of pregnancy

2017 Clinical Trials

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