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Pruritus in Pregnancy

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21. A Study of SK-1405 in Hemodialysis Patients With Uremic Pruritus

A Study of SK-1405 in Hemodialysis Patients With Uremic Pruritus A Study of SK-1405 in Hemodialysis Patients With Uremic Pruritus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of SK-1405 (...) in Hemodialysis Patients With Uremic Pruritus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03218501 Recruitment Status : Completed First Posted : July 14, 2017 Last Update Posted : March 8, 2019 Sponsor: Sanwa Kagaku Kenkyusho Co., Ltd. Information provided by (Responsible Party): Sanwa Kagaku Kenkyusho Co

2017 Clinical Trials

22. Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Plaque Psoriasis

consistent with severe pruritus. WI-NRS scores during the 2 weeks of screening consistent with sever pruritus. All female subjects who are of childbearing potential must be willing to practice highly effective contraception (i.e., pregnancy prevention method with a failure rate of < 1% per year) from the time of the initial Screening visit until 2 weeks after last dose of study drug. Weight ≥ 32 kg at the Screening and Baseline visits. Willing and able to complete daily eDiary entries within a consistent (...) Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Plaque Psoriasis Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Plaque Psoriasis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2017 Clinical Trials

23. Extension Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus

to comply with the study schedules and all study requirements; Males or females 18 years of age or older; Currently on hemodialysis for end-stage renal disease and has been categorized as experiencing moderate to severe uremic pruritus; If female: Is not of childbearing potential (surgically sterile or postmenopausal, as defined in Section 6.5.1.6); or Has a negative serum pregnancy test at screening and agrees to use acceptable contraceptive measures (as defined in Section 6.5.1.6) from the time (...) Extension Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Extension Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2017 Clinical Trials

24. Safety, Efficacy, and Tolerability of SNA-120 in Subjects With Pruritus Associated With Psoriasis Vulgaris

Safety, Efficacy, and Tolerability of SNA-120 in Subjects With Pruritus Associated With Psoriasis Vulgaris Safety, Efficacy, and Tolerability of SNA-120 in Subjects With Pruritus Associated With Psoriasis Vulgaris - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Safety, Efficacy, and Tolerability of SNA-120 in Subjects With Pruritus Associated With Psoriasis Vulgaris The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03322137 Recruitment Status : Completed First Posted : October 26, 2017 Last Update Posted

2017 Clinical Trials

25. Risk Factors for Postoperative Nausea, Vomiting and Pruritus

Risk Factors for Postoperative Nausea, Vomiting and Pruritus Risk Factors for Postoperative Nausea, Vomiting and Pruritus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Risk Factors for Postoperative (...) Nausea, Vomiting and Pruritus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03178058 Recruitment Status : Recruiting First Posted : June 6, 2017 Last Update Posted : June 6, 2017 See Sponsor: Rabin Medical Center

2017 Clinical Trials

26. CRACKCast E177 – Acute Complications of Pregnancy

encephalopathy may also result. Intrahepatic cholestasis of pregnancy typically presents with generalized pruritus and mild jaundice. Nausea and Vomiting in Pregnancy Hyperemesis gravidarum is defined as nausea and vomiting that cause starvation metabolism, weight loss, dehydration, and prolonged ketonemia and ketonuria. Initial management involves rehydration with IV fluids, antiemetics, and demonstration of ability to take oral hydration. Thromboembolism in Pregnancy Thromboembolic disease accounts (...) CRACKCast E177 – Acute Complications of Pregnancy CRACKCast E177 - Acute Complications of Pregnancy - CanadiEM CRACKCast E177 – Acute Complications of Pregnancy In by Adam Thomas May 14, 2018 This episode of CRACKCast covers Rosen’s Chapter 177, Acute Complications of Pregnancy. This chapter covers many acute issues that arise during the unique physiologic state that is pregnancy, from first trimester bleeding to diagnostic challenges and management of other conditions during pregnancy. Also

2018 CandiEM

27. Impacts of different methods of conception on the perinatal outcome of intrahepatic cholestasis of pregnancy in twin pregnancies (PubMed)

Impacts of different methods of conception on the perinatal outcome of intrahepatic cholestasis of pregnancy in twin pregnancies Twin pregnancies have a higher prevalence of intrahepatic cholestasis of pregnancy (ICP) than single pregnancies. It is unknown whether in vitro fertilization-embryo transfer (IVF-ET) influences the fetal outcomes in twin pregnancies complicated by ICP. This study aimed to explore the impact of IVF-ET on the perinatal outcomes of ICP in twin pregnancy. Clinical data (...) from 142 twin pregnant women complicated with ICP were retrospectively analyzed, including 51 patients who conceived through IVF-ET (IVF group) and 91 patients with spontaneous conception (SC group). Several biochemical indicators and perinatal outcomes were analyzed. Compared to the SC group, the IVF group had a higher incidence of early-onset ICP (P = 0.015) and more frequent clinical symptoms (P = 0.020), including skin pruritus, skin scratch, and jaundice. Furthermore, the IVF group had higher

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2018 Scientific reports

28. Naloxone Hydrochloride Study for Relief of Pruritus in Patients With MF or SS Forms of CTCL

Naloxone Hydrochloride Study for Relief of Pruritus in Patients With MF or SS Forms of CTCL Naloxone Hydrochloride Study for Relief of Pruritus in Patients With MF or SS Forms of CTCL - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Naloxone Hydrochloride Study for Relief of Pruritus in Patients With MF or SS Forms of CTCL The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02811783 Recruitment Status : Recruiting First Posted

2016 Clinical Trials

29. Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus

a negative serum pregnancy test and agree to practice an acceptable form of birth control for the duration of the study Male patients that are not biologically or surgically sterile must agree to practice an acceptable from of birth control for the duration of the study Weigh between 88.2 lb (40.0 kg) and 297.6 lb (135.0 kg). Patient must self-report pruritus in the month prior to screening. If patient is receiving treatment for itch, this treatment must be stable prior to screening and during treatment (...) Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2016 Clinical Trials

30. Central Mechanisms of Chronic Pruritus: Functional and Structural Brain Imaging.

Central Mechanisms of Chronic Pruritus: Functional and Structural Brain Imaging. Central Mechanisms of Chronic Pruritus: Functional and Structural Brain Imaging. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Central Mechanisms of Chronic Pruritus: Functional and Structural Brain Imaging. (PRURIM) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02828787 Recruitment Status : Recruiting First Posted : July 12, 2016 Last

2016 Clinical Trials

31. Cholestasis associated Pruritus

VI. Management (or if limited) Has also been used in of pregnancy Used in primary biliary (intense itch) May be indicated in refractory cases receptor antagonist IV PO VII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Cholestasis associated Pruritus." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Dermatology About (...) Cholestasis associated Pruritus Cholestasis associated Pruritus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cholestasis associated

2018 FP Notebook

32. Pruritus Causes

water contact (follows warm bath) Pregnancy (See ) Prurigo of Pregnancy or ( ) Pruritic of Pregnancy Medications , , B s Ointments with high concentrations of inert oil s (especially via spinal administration) Allergen or irritant exposure (e.g. ) Heat exposure: ( ) Cat exposure glass exposure ( glass Dermatitis) VI. Causes: Age-related Pruritus Children s Elderly VII. References See Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term (...) Pruritus Causes Pruritus Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pruritus Causes Pruritus Causes Aka: Pruritus Causes

2018 FP Notebook

33. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. (PubMed)

and determine whether elevated bile acid concentrations were associated with the risk of stillbirth and preterm birth.We did a systematic review by searching PubMed, Web of Science, and Embase databases for studies published from database inception to June 1, 2018, reporting perinatal outcomes for women with intrahepatic cholestasis of pregnancy when serum bile acid concentrations were available. Inclusion criteria were studies defining intrahepatic cholestasis of pregnancy based upon pruritus and elevated (...) Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic cholestasis of pregnancy in women with increased serum bile acid concentrations

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2019 Lancet

34. Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. (PubMed)

Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and increased serum bile acid concentrations, is associated with increased rates of stillbirth, preterm birth, and neonatal unit admission. Ursodeoxycholic acid is widely used as a treatment without an adequate evidence base. We aimed to evaluate whether ursodeoxycholic acid reduces adverse (...) perinatal outcomes in women with intrahepatic cholestasis of pregnancy.We did a double-blind, multicentre, randomised placebo-controlled trial at 33 hospital maternity units in England and Wales. We recruited women with intrahepatic cholestasis of pregnancy, who were aged 18 years or older and with a gestational age between 20 weeks and 40 weeks and 6 days, with a singleton or twin pregnancy and no known lethal fetal anomaly. Participants were randomly assigned 1:1 to ursodeoxycholic acid or placebo

2019 Lancet Controlled trial quality: predicted high

35. Liver Disease and Pregnancy

outcomes ( 48 ). UCDA is more eff ective than cholestyramine or dexamethasone in controlling pruritus. Dexamethasone may be used, if needed, to promote fetal lung maturity before delivery, as there is a higher rate of prematurity in IHCP . Table 3 . Liver diseases unique to pregnancy Disorder Trimester Management HG First through 20 weeks Supportive management IHCP Second/third Ursodeoxycholic acid 10–15 mg/kg Early delivery at 37 weeks AFLP Third Women with AFLP should be delivered promptly Infant (...) Liver Disease and Pregnancy nature publishing group 1 © 2016 by the American College of Gastroenterology The American Journal of GASTROENTEROLOGY PRACTICE GUIDELINES To determine the level of evidence, the results from the selected papers with the greatest level of evidence were extrapolated and utilized in the GRADE program ( h t t p://w w w .gradep r o .o r g ). A summary of the recommendations are outlined in Table 1 . EVALUATION OF THE PREGNANT PATIENT WITH ABNORMAL LIVER ENZYMES

2016 American College of Gastroenterology

36. Is ursodeoxycholic acid effective for intrahepatic cholestasis of pregnancy?

Is ursodeoxycholic acid effective for intrahepatic cholestasis of pregnancy? Intrahepatic cholestasis of pregnancy is a condition associated with fetal morbidity and mortality. Ursodeoxycholic acid has been proposed as a treatment alternative, but its use remains controversial. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified three systematic reviews including eight randomized trials. We combined the evidence using meta-analysis and generated (...) a summary of findings table following the GRADE approach. We concluded ursodeoxycholic acid reduces prematurity risk and need for admission in neonatal intensive care units. It might also reduce maternal pruritus.

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2017 Medwave

37. Nausea/vomiting in pregnancy

Nausea/vomiting in pregnancy Nausea/vomiting in pregnancy - NICE CKS Share Nausea/vomiting in pregnancy: Summary The majority of women vomit or feel nauseated in early pregnancy. Symptoms usually begin between the fourth and seventh weeks of gestation and usually resolve around the 20th week of pregnancy. Hyperemesis gravidarum is a diagnosis of exclusion characterized by prolonged and severe nausea and vomiting, dehydration, electrolyte imbalance, ketonuria, and body weight loss of more than 5 (...) % of pre-pregnancy weight. Findings which may suggest an alternative diagnosis include: Onset of symptoms after 11 weeks of gestation. Abdominal pain or tenderness (more than mild epigastric tenderness after retching). Fever. Headache or abnormal neurological examination. Goitre. Complications are more likely in women with severe vomiting and include: Maternal — weight loss, dehydration, hyponatraemia, vitamin deficiencies, Mallory-Weiss tear or oesophageal rupture, increased risk of venous

2018 NICE Clinical Knowledge Summaries

38. Women successfully treated for severe intrahepatic cholestasis of pregnancy do not have increased risks for adverse perinatal outcomes. (PubMed)

into the mild ICP (serum bile acids (SBA) ≤40 μmol/L throughout pregnancy) and severe ICP (SBA >40 μmol/L during pregnancy but fell after ursodeoxycholate therapy) groups. Baseline characteristics, laboratory investigations, and maternal and neonatal outcomes were assessed. Logistic regression was used to identify factors associated with meconium staining of amniotic fluid (MSAF) and APOs.Seventy-three patients were included (mild ICP group, n=47; severe ICP group, n=26). Pruritus was more common (...) Women successfully treated for severe intrahepatic cholestasis of pregnancy do not have increased risks for adverse perinatal outcomes. Intrahepatic cholestasis of pregnancy (ICP) increases adverse perinatal outcome (APO) incidence. Whether successful treatment of severe ICP reduces APO risk is unclear.This retrospective, single-center study in China enrolled consecutive women with ICP who had term delivery (≥37 weeks, singleton) between August 2013 and June 2016. Patients were divided

2019 Medicine

39. Pruritus in Pregnancy

Pruritus in Pregnancy Pruritus in Pregnancy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pruritus in Pregnancy Pruritus (...) in Pregnancy Aka: Pruritus in Pregnancy , Pregnancy Related Pruritus , Pruritus gravidarum , Prurigo gravidarum II. Causes See Common, intense involving May spread to thighs, buttocks, s and arms Prurigo of Pregnancy (Common) Onset in second-half of pregnancy s and s over arms and Associated with or (uncommon) Autoimmune disorder with association Occurs in second-half of pregnancy s and bullae form on , extremities (Common) No in mild form (Prurigo gravidarum) Trunk and extremity itching without rash

2015 FP Notebook

40. Interventions for treating cholestasis in pregnancy. (PubMed)

Interventions for treating cholestasis in pregnancy. Obstetric cholestasis has been linked to adverse maternal and fetal/neonatal outcomes. As the pathophysiology is poorly understood, therapies have been empiric. The first version of this review, published in 2001, and including nine randomised controlled trials involving 227 women, concluded that there was insufficient evidence to recommend any of the interventions alone or in combination. This is the first update.To evaluate (...) the effectiveness and safety of therapeutic and delivery interventions in women with cholestasis of pregnancy.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (20 February 2013) and reference lists of identified studies.Randomised controlled trials that compared two intervention strategies for women with a clinical diagnosis of obstetric cholestasis.The review authors independently assessed trials for eligibility and risk of bias. We independently extracted data and checked

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2013 Cochrane

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