How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,037 results for

Pruritus in Pregnancy

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

241. Scabies

on the anterior trunk and limbs. Crusted scabies occurs in immuno-compromised hosts and may be associated with reduced or absent pruritus. Recommended treatments are permethrin 5% cream, oral ivermectin and benzyl benzoate 25% lotion. Alternative treatments are malathion 0.5% aqueous lotion, ivermectin 1% lotion and sulfur 6-33% cream, ointment or lotion. Crusted scabies therapy requires a topical scabicide and oral ivermectin. Mass treatment of large populations with endemic disease can be performed (...) with normal immune response; -intense pruritus which is worse at night; -erythematous papules disseminated on the periumbilical area, waist, genitalia, breasts, buttocks, axillary folds, fingers (including interdigital spaces), wrists and extensor aspects of the limbs. The head, palms and soles are usually spared in adults; -the papules are small, often excoriated with haemorrhagic crusts on top; -the burrow (a pathognomonic sign) appears as a thin, brown-grey line of 0.5-1 cm but is rarely observed due

2017 European Dermatology Forum

242. Psoriasis

. There is no evidence that secukinumab has any negative effect on diabetes control. 24 Kidney failure/Renal impairment In the pivotal clinical trials there was no evidence for treatment emergent adverse events related to renal function 27, 28 . Wish for pregnancy in near future Pregnancy “Women of childbearing potential should use an effective method of contraception during treatment and for at least 20 weeks after treatment. There are no adequate data from the use of secukinumab in pregnant women. Animal studies (...) of active and chronic infection o Check for contraception and breastfeeding o Check for need for vaccines (see “vaccination”) o Check for hypersensitivity, metabolic, gastrointestinal and renal disorders/dysfunction, underweight, o Check for depression, anxiety o Check for co-medication: CYP3A4 enzyme inducers • Laboratory controls including pregnancy test (see Table 1) During-treatment • Objective assessment of the disease (such as PASI/BSA/PGA; arthritis) • HRQoL (such as DLQI/ Skindex-29 or -17

2017 European Dermatology Forum

243. Injectable Extended-Release Naltrexone to Treat Opioid Use Disorder

, blood-borne infections, and fatal overdose. 4 In addition, babies born to mothers who used opioids during pregnancy are at increased risk for neonatal abstinence syndrome, a condition that can be life-threatening if not promptly recognized and treated. 5 While heroin has historically been the most commonly misused opioid, non-medical use of prescription opioid analgesics (such as morphine, oxycodone, hydromorphone, and fentanyl) is now the dominant form of opioid misuse. 6 “Misuse” has been defined (...) , marijuana, or nicotine Current alcohol dependence Positive urine test for cocaine or amphetamines Naltrexone use within past 6 months Pregnancy or breastfeeding Design: Multi-centre, randomized, placebo-controlled, double-blind Intervention: 380 mg Vivitrol every 4 weeks Comparator: Placebo injection every 4 weeks Setting: 13 clinical sites in Russia Duration: 24 weeks Mean age, years: 29.4 to 29.7 Caucasian, N (%): 248 (99.2) Male, N (%): 220 (88.0%) HIV serology positive, N (%): 103 (41.2) Hepatitis C

2017 CADTH - Issues in Emerging Health Technologies

244. CRACKCast E098 – Sexually Transmitted Infections

of clinical signs or symptoms. <12 months – early latent (infectious). >12 months – late latent (non-infectious with the exception of pregnant patients). Tertiary Cardiovascular and gummatous disease (uncommon) including aortitis, aortic aneurysm, and gummatous lesions of the skin, bone, and other organs. Diagnosis: Treponema pallidum is the spirochete that causes syphilis. Fastidious organism and cannot be cultured in the laboratory. Confirmed with dark field microscopy or serologic testing (non (...) . Penicillin remains drug of choice in pregnancy, neurosyphilis, and congenital syphilis, even in the presence of penicillin allergy. Admission for desensitization and treatment. Question 7) What is the causes of chancroid? How is it managed? Chancroid – Ulcerating infection caused by gram-negative organism Haemophilus ducreyi . Common in developing world but extremely uncommon in Western world. Incubation of less than a week preceded by tender erythematous papule that rapidly ulcerates to form multiple

2017 CandiEM

245. Injectable Extended-Release Naltrexone to Treat Opioid Use Disorder

, blood-borne infections, and fatal overdose. 4 In addition, babies born to mothers who used opioids during pregnancy are at increased risk for neonatal abstinence syndrome, a condition that can be life-threatening if not promptly recognized and treated. 5 While heroin has historically been the most commonly misused opioid, non-medical use of prescription opioid analgesics (such as morphine, oxycodone, hydromorphone, and fentanyl) is now the dominant form of opioid misuse. 6 “Misuse” has been defined (...) , marijuana, or nicotine Current alcohol dependence Positive urine test for cocaine or amphetamines Naltrexone use within past 6 months Pregnancy or breastfeeding Design: Multi-centre, randomized, placebo-controlled, double-blind Intervention: 380 mg Vivitrol every 4 weeks Comparator: Placebo injection every 4 weeks Setting: 13 clinical sites in Russia Duration: 24 weeks Mean age, years: 29.4 to 29.7 Caucasian, N (%): 248 (99.2) Male, N (%): 220 (88.0%) HIV serology positive, N (%): 103 (41.2) Hepatitis C

2017 CADTH - Issues in Emerging Health Technologies

246. CRACKCast E099 – Urological Disorders

Cough, abdominal pain, nausea, vomiting Ciprofloxacin 400 mg every 12 hours GI disturbance, headache, dizziness, tremors, restlessness, confusion, rash, Candida infections Levofloxacin 500 mg every 24 hours Same as for ciprofloxacin [6] What are safe antibiotic options for bacteriuria in pregnancy? How is pyelonephritis managed in pregnancy? A couple key points about the pregnant patient with a UTI: Bacteriuria in pregnancy – gets treated even if the patient is asymptomatic If the patient (...) Hematuria UTIs in Adults – Rosens in Perspective Most frequent bacterial infection in adults, one of the most common causes of sepsis Diagnosis is made by: Urinary specific symptoms (dysuria, frequency, urgency, hematuria, suprapubic/CVA discomfort) Bacteriuria (note this alone does not equal UTI! – unless patient Is pregnant or immunocompromised) No other source of infection Classified as: Lower (bladder only) vs. upper (ureters and kidney) Uncomplicated or complicated How is UTI diagnosed? What

2017 CandiEM

247. CRACKCast E096 – Anorectal Disorders

(bright red, painful, blood on toilet paper) vs. internal (bright red, painless, drips in the toilet bowl or is streaked in with the stool). The external ones originate distal to the dentate line and are covered in anoderm (MSE). The Internal ones originate proximal to the dentate line and are covered in mucosa. HOWEVER, people can have mixed type hemorrhoids too! Risk fx: Family hx of hemorrhoids Straining and constipation Pregnancy & traumatic deliveries Prolonged sitting Heavy lifting Portal (...) ! Managed Medically using the WASH approach. ● Warm water sitz ● Analgesia ● Stool softeners ● High fiber diet See below Usually can be managed supportively as well. (they will ulcerate and ooze dark blood in a few days). But, if within 72 hrs of onset of symptoms, they can have the clot EXCISED. Be sure to warn patients that excision will lead to evacuation of the clot, but also rebleeding, swelling and the formation of a skin tag. People that are bad candidates for this: kids, pregnant women

2017 CandiEM

248. CrackCAST E129 – Bacteria

dose. The most common side effects of tetanus vaccine are minor: local swelling, pain, erythema, pruritus, fever, nausea, vomiting, malaise, and nonspecific rash. Local reactions do not preclude future use of toxoid. No evidence exists that tetanus and diphtheria toxoids are teratogenic. HTIG is not contraindicated in pregnancy. [12] What is the mechanism of action of botulinum toxin? And describe the 5 types of botulism. Botulism is a rare life-threatening paralytic illness caused by neurotoxins (...) and secretions; contact lenses should be removed to avoid permanent staining. Ceftriaxone IM (pregnancy; patients who will not take rifampin) IM ceftriaxone (125 mg for children younger than 15 years old and 250 mg for those older than 12 years old) is effective and is an alternative for pregnant women and for people in whom compliance with an oral regimen cannot be ensured. Ciprofloxacin 500 mg PO x 1 dose (for adults) [19] What are the risk factors for toxic shock syndrome? TSS is a toxin-mediated systemic

2017 CandiEM

249. CRACKCast E120 – Dermatologic presentations

of antiviral therapy as long as new lesions are appearing]. Doses to know: Valacyclovir : 1000 mg three times daily for seven days Famciclovir : 500 mg three times daily for seven days Acyclovir : 800 mg five times daily for seven days (this is the GO-TO drug for PREGNANT women with herpes zoster) Supportive care is important for pain and pruritus control. IV administration of acyclovir may be of some benefit in the treatment of severe ocular herpes zoster. Treatment includes mydriasis and the application (...) are a useful alternative to older sedating ones to control pruritus and histamine-mediated rashes while allowing the patient to remain active. Scabies infestations should be diagnosed clinically and treated expeditiously even without definitive proof of the infestation. Medication reactions are common and may results from any medication, typically within 4 to 21 days after taking the medication. Rashes that are associated with mucosal lesions, blisters, or desquamating skin are often caused by significant

2017 CandiEM

250. CRACKCast E119 – Allergy, Hypersensitivity, Angioedema, and Anaphylaxis

. Tract · Bronchospasm Cardiovascular · Tachycardia · Hypotension · Shock · Syncope · Dysrhythmias · Cardiac Arrest Integument · Urticaria · Pruritus · Warmth · Flushing · Angioedema Eyes · Conjunctivitis Gastrointest. Tract · Dysphagia · Abdominal cramping · Nausea/Vomiting · Diarrhea · Tenesmus Central Nervous S. · Sense of impending doom · Restlessness · Anxiety Heme · Disseminated Intravascular Coagulopathy Genitourinary Tract · Urinary incontinence [4] Define Anaphylaxis, and list the clinical (...) edema often complain of hoarseness, throat tightness, or stridor. [5] List 4 risk factors for anaphylaxis and increased anaphylaxis severity and mortality Refer to box 109.2 in Rosen’s 9 th Edition for the comprehensive summary of the risk factors for anaphylaxis, severity of anaphylaxis, and mortality related to anaphylaxis Risk Factors for Anaphylaxis Age and sex Pregnant women, infants, teenagers, elderly Route of administration Parenteral > oral Higher social economic status Time of the year

2017 CandiEM

251. British Association of Dermatologists guidelines for the management of pemphigus vulgaris

investigations The following additional investigations should be considered prior to commencing treatment: full blood count and differen- tial, urea and electrolytes, liver function tests, fasting glucose and glycated haemoglobin (HbA1c), fasting lipids, antinuclear antibody (differential of pemphigus erythematosus), urinaly- sis, blood pressure, weight, height (children) and a pregnancy test in female patients at risk of pregnancy. Current guidelines on prevention of osteoporosis 30 should be followed, so

2017 British Association of Dermatologists

252. Guidelines on the management of abnormal liver blood tests

destruction of platelets occurs owing to antiplatelet immunoglobulin. Alkaline phosphatase (ALP) is produced mainly in the liver (from the biliary epithelium) but is also found in abundance in bone and in smaller quantities in the intestines, kidneys and white blood cells. Levels are physiologically higher in child- hood, associated with bone growth, and in pregnancy due to placental production. Pathologically increased levels occur mainly in bone disease (eg, metastatic bone disease and bone fractures (...) liver disease Autoimmune liver disease is more common in patients with pre-existing autoimmune diseases, and liver blood tests may be appropriate if clinical symptoms change to suggest development of liver disease—for example, pruritus in primary biliary chol- angitis. Patients with inflammatory bowel disease (including ulcerative colitis and Crohn’s disease) have a particular notable risk of developing the autoimmune cholestatic liver disease, primary sclerosing cholangitis; disease prevalence

2017 British Society of Gastroenterology

253. Dupilumab and Crisaborole for Atopic Dermatitis: Effectiveness and Value

not provide direct evidence on dupilumab therapy as compared with topical calcineurin inhibitor therapy in such patients, since we are uncertain how many patients in the trial had failed topical calcineurin inhibitors. Patient-reported Outcomes Dupilumab improved patient quality of life as measured by DLQI and improved patient symptoms including individual measures of pruritus, and scoring systems looking at broader patient outcomes, patient-reported outcomes, and measures of anxiety and depression (...) phi.adj[i,k,j] 0) for (j in 1:nc[i]-1) { # LOOP THROUGH CATEGORIES r[i,k,j] ~ dbin(q[i,k,j],n[i,k,j]) # binomial likelihood q[i,k,j] 5, phi(x)=1 phi.adj[i,k,j] 0 and =2 lesion partial clearance: 1) 48.0, 2) 8.0 Pruritus mean severity score (estimated from graph): 1) 0.6 Erythema: 1) 0.8 Lichenification: 1) 0.9 Excoriation: 1) 0.4 Exudation: 1) 0.1 Application-site reactions, % 1) 12, 2) 12 Pimecrolimus Eichenfield, 2002 39 Good Quality Publication RCT, multi-center, double-blind 6 weeks 1

2017 California Technology Assessment Forum

254. Hodgkin Lymphoma: ESMO Clinical Practice Guidelines

are characterised by the expression of CD20 and CD45 but lack CD15 and CD30. Stagingandriskassessment The diagnostic work-up is shown in Table 1. The medical history including the presence of B symptoms (fever, drenching night sweats, unexplained weight loss> 10% over 6 months) and other disease-related symptoms such as fatigue, pruritus and alcohol- induced pain as well as the results of a physical examination should be recorded [1]. Chest X-ray and a contrast-enhanced computed tomography (CT) scan of the neck (...) affection) Staging and risk strati?cation Medical history and physical examination X-ray of the chest Contrast-enhanced CT scan of the neck, chest and abdomen PET Full blood cell count and blood chemistry, ESR HBV, HCV and HIV screening Pretreatment examinations ECG Echocardiography Pulmonary function test Reproductive counselling (in patients of reproductive age) Serum pregnancy test (in female patients of reproductive age) Consultation of an ear, nose and throat specialist including a ?breoptic

2018 European Society for Medical Oncology

256. Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of NASPGHAN and ESPGHAN

–associated cholestasis (PNAC) (82). This is a major confounder in the evaluation of the cholestatic infant, and it is often worthwhile for caregivers to note the timing and initiation of PN in relation to serial measurements of fractionated bilirubin levels, especially if direct hyperbilirubinemia precedes the initiation of PN. Details in the family history including previous and current pregnancy such as miscarriages, pruritus, or overt liver dysfunction in maternal history should be noted; history (...) hyperbilirubinemia Prenatal history Prenatal ultrasonography ?ndings Presence of choledochal cyst, cholelithiasis, bowel anomalies or concern for syndrome Cholestasis of pregnancy May be seen in heterozygotes for PFIC gene mutations; mitochondrial disorder Acute fatty liver of pregnancy Neonatal long-chain 3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) de?ciency Maternal infections TORCH infections Infant history Gestational age Prematurity as a risk factor for neonatal hepatitis SGA Increased risk of neonatal

2017 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

257. CRACKCast E062 – Venomous Animal Injuries

crampy pain in the bite, with spread to the rest of the body over the next hour. The abdomen may become board like with minimal tenderness. Pregnant women may go into premature labour. Other symptoms include dizziness, restlessness, ptosis, N/V, pruritus, dyspnea, and well… just about anything! ECG may indicate dig toxicity like changes. Management initially is cleaning with soap, water, and tetanus. Patients with symptoms should have lab work including: CBC, lytes, BUN, Creatinine, Coags, UA (...) , and ECG. Treatment includes diazepam for muscle spasms, parenteral analgesics for pain and admission for monitoring. Young, elderly and pregnant patients should prompt consider for antivenin Lyovac – a horse serum derivative. Hard criteria for antivenin include seizures, respiratory failure, uncontrolled HTN, pregnancy, and lack of response to prior therapies. Dose is one vial in 50ml NS over 15 minutes. Allergic reactions are common. [6] Describe a brown recluse spider and expected management goals

2017 CandiEM

259. CRACKCast E090 – Liver and Biliary Tract

) Empiric ceftriaxone ? 6) List 6 stigmata of chronic liver disease and list 3 complications. This stuff is all due to loss of hepatic metabolic or synthetic function → decreased portal vein blood flow → portal hypertension. Stigmata Scleral / cutaneous icterus +/- pruritus Hepatomegaly Spider angiomata Caput medusa Patchy ecchymosis with thin skin Splenomegaly Gray / acholic stools Gynecomastia Muscle wasting Palmar erythema Dupuytren’s contractures Testicular atrophy Complications: Hepatocellular (...) gradient > 1.1 g/dL (>11 g/L) can be an early indicator of SBP. (subtract the albumin in the ascitic fluid, from the serum albumin level) This can also be used to determine whether the ascites is from portal hypertension or not 10) List 3 types of drug-induced liver disease. Cytotoxic (“ALT”) Acetaminophen Lovastatin Tetracycline Cholestatic (“ALP”) Azathioprine haLdoL Phenobarbital Veno-occlusive (“AAA”) Anabolic steroids Azathioprine Anti-pregnancy (OCP’s) 11) What are two types of hepatic abscesses

2017 CandiEM

260. Buprenorphine Implant for the Treatment of Opioid Use Disorder

reported implant site adverse events such as pain, pruritus, and erythema were mild and resolved without treatment. There was no evidence of unscheduled or attempted implant removal and no cases of implant migration. All US health care providers must complete a live training program on insertion and removal procedures, and become certified in the restricted program called the Probuphine Risk Evaluation and Mitigation Strategy program (REMS), before prescribing Probuphine or performing insertions (...) and removals. Background Opioid use disorder (also known as opioid dependence), defined as a problematic pattern of opioid use leading to clinically significant impairment or distress, is a growing public health concern in Canada that is associated with significant morbidity and mortality. 1-3 Individuals with opioid use disorder are at greater risk for incarceration, blood-borne infections, and fatal overdose. 4 In addition, babies born to mothers who used opioids during pregnancy are at increased risk

2017 CADTH - Issues in Emerging Health Technologies

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>