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Pruritus Causes

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1. Diabetes and pruritus: cause, consequence or coincidence? - a systematic review

Diabetes and pruritus: cause, consequence or coincidence? - a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2020 PROSPERO

2. Pruritus

-568752 Fax: 0049-6221-565584 Email: elke.weisshaar@med.uni-heidelberg.de 2 Abstract Pruritus is a frequent symptom in medicine. Population-based studies show that every 5 th person in the general population has suffered from chronic pruritus (CP) at least once in the lifetime with a 12-month incidence of 7%. In patient populations its frequency is much higher depending on the underlying cause, ranging from around 25% in haemodialysis patients to 100% in skin diseases such as urticaria and atopic (...) dermatitis (AD). Pruritus may be the result of a dermatological or non-dermatological disease. Especially in non-diseased skin it may be caused by systemic, neurological or psychiatric diseases, as well as being a side effect of medications. In a number of cases CP may be of multifactorial origin. Pruritus needs a precise diagnostic work-up. Management of CP comprises treatment of the underlying disease and topical treatment modalities, including symptomatic antipruritic treatment, ultraviolet

2019 European Dermatology Forum

3. British Association of Dermatologists? guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis

. Symptomatic measures may be appro- priate in patients where no cause can be identi?ed or treated. More directed management can be divided into topical treat- ments, systemic treatments, phototherapy, psychological approaches or alternative therapies. 5,24 Palliative care is a spe- cialized situation and, in general, the therapy of the pruritus should be centred on the individual circumstances of the patient. 25 7.0 Investigation of generalized pruritus without rash and interventions for secondary (...) Aprospectivecase–controlstudyshowedthatthemeanserum ironlevelsinthepopulation ofpatients withpruritus wassignif- icantly lowerthanthat inthecontrolgroup,with nomedianage differencebetweenthetwogroups.Furthermore,themostcom- mon cause of generalized pruritus in patients with underlying systemicdiseasewasfoundtobeironde?ciencyanaemia,which respondedtoironreplacement(25%ofallpatientswithpruritus with systemic disease). 30 Therefore, we recommend that full blood count and ferritin levels should be checked in all

2018 British Association of Dermatologists

4. Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP Pathway Full Text available with Trip Pro

Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP Pathway Increased expression of Th22 cytokine IL-22 is a characteristic finding in atopic dermatitis (AD). However, the specific role of IL-22 in the pathogenesis of AD in vivo has yet to be elucidated. Consistent with observations in human AD, IL-22 was significantly increased in the AD skin of mice after epicutaneous sensitization to house (...) dust mite allergen. Utilizing a skin-specific inducible transgenic system, we show in the present study that expression of IL-22 in the skin of mice caused an AD-like phenotype characterized by chronic pruritic dermatitis associated with Th2-biased local and systemic immune responses, downregulation of epidermal differentiation complex genes, and enhanced dermatitis upon epicutaneous allergen exposure. IL-22 potently induced the expression of gastrin-releasing peptide (GRP), a neuropeptide

2017 Journal of immunology (Baltimore, Md. : 1950)

5. Interventions for pruritus of unknown cause [Cochrane protocol]

Interventions for pruritus of unknown cause [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g

2019 PROSPERO

6. Pruritus Causes

Pruritus Causes Pruritus Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pruritus Causes Pruritus Causes Aka: Pruritus Causes (...) , Dermatologic Causes of Pruritus , Systemic Causes of Pruritus , Localized Causes of Pruritus , Medication Causes of Pruritus , Environmental Causes of Pruritus II. Causes: Dermatologic Conditions or (most common cause) ( suggests worse prognosis) Local Infection or bites corporis (lice) s III. Causes: Systemic Severe ( ) or (30-50%) Provoked by hot shower or bath Pricking type itch may persist for hours Rapid weight loss (e.g. ) (4-11% long-standing ) Cholestasis (bile salt protease release in skin) See

2018 FP Notebook

7. Can genetic testing guide the therapy of cholestatic pruritus? A case of benign recurrent intrahepatic cholestasis type 2 with severe nasobiliary drainage‐refractory itch Full Text available with Trip Pro

Can genetic testing guide the therapy of cholestatic pruritus? A case of benign recurrent intrahepatic cholestasis type 2 with severe nasobiliary drainage‐refractory itch Benign recurrent intrahepatic cholestasis (BRIC) is a peculiar familial disease caused by mutations of the genes encoding hepatocanalicular flippase for phosphatidylserine (ATP8B1; BRIC type 1) or the bile salt export pump (ABCB11; BRIC type 2). Here, we report on a patient with nasobiliary drainage-refractory BRIC type 2

2018 Hepatology communications

8. Prognostic importance and determinants of uremic pruritus in patients receiving peritoneal dialysis: A prospective cohort study. Full Text available with Trip Pro

was used to measure the intensity of uremic pruritus. The composite endpoint of PD technique failure or all-cause death was assessed using a multivariable Cox proportional hazards model. The determinants for the VAS score of uremic pruritus was assessed using a multivariable linear regression model.Among the 85 PD patients, 24 (28%) had uremic pruritus. During a median follow-up of 28.0 months, 12 patients experienced technique failure, and 7 died. We found that a higher VAS score of pruritus intensity (...) Prognostic importance and determinants of uremic pruritus in patients receiving peritoneal dialysis: A prospective cohort study. Uremic pruritus is a common and frustrating symptom among patients receiving peritoneal dialysis (PD). This study aimed to examine the prognostic importance of uremic pruritus and to identify the determinants for higher pruritus intensity in PD patients.We conducted a prospective cohort study of patients receiving maintenance PD. A visual analogue scale (VAS) score

2018 PLoS ONE

9. Reasons for underreporting of uraemic pruritus in people with chronic kidney disease: A qualitative study. Full Text available with Trip Pro

Reasons for underreporting of uraemic pruritus in people with chronic kidney disease: A qualitative study. Uraemic pruritus, or itch, is common in people with chronic kidney disease (CKD) and has a negative impact on their lives and well-being. However, for reasons currently unknown, itch often remains unreported and therefore untreated.To explore reasons for underreporting of itch in order to provide pointers for improving itch reporting and management in people with CKD.We interviewed adult (...) patients with CKD who self-reported experiencing itching in the last three years (n=25), nephrologists (n=10) and nurses (n=12) from three kidney services in the United Kingdom. Topic guides were informed by previous studies and a theoretical model of self-regulation. We conducted a thematic analysis of verbatim transcripts using Framework Analysis.We identified three main themes reflecting factors that may influence whether itch is reported: knowledge on causes and treatment of itch (lack of awareness

2019 Journal of pain and symptom management

10. Examining the association between pruritus and quality of life in patients with atopic dermatitis treated with crisaborole. (Abstract)

Examining the association between pruritus and quality of life in patients with atopic dermatitis treated with crisaborole. Pruritus is a leading cause of reduced health-related quality of life (QoL) in atopic dermatitis (AD). Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate AD. In identical Phase 3 studies (NCT02118766, NCT02118792), crisaborole reduced disease and pruritus severity versus vehicle.Quantify the relationship between (...) pruritus and QoL using data from these studies.Patients aged ≥2 years were randomly assigned 2 : 1 to receive crisaborole:vehicle twice daily for 28 days. QoL was measured at baseline and day 29 using the Dermatology Life Quality Index (DLQI; patients aged ≥16 years), the Children's Dermatology Life Quality Index (CDLQI; patients aged 2-15 years) and the Dermatitis Family Impact (DFI; caregivers of patients aged 2-17 years). Pruritus was measured using the Severity of Pruritus Scale (SPS), a 4-point

2019 Journal of the European Academy of Dermatology and Venereology Controlled trial quality: uncertain

11. Comparison of pruritus and sensory qualities induced by capsaicin, histamine and cowhage. (Abstract)

Comparison of pruritus and sensory qualities induced by capsaicin, histamine and cowhage. In skin diseases and experimental models of pruritus, pure itch is accompanied by additional sensations that are poorly characterized.This study compared the sensory qualities evoked by different models of experimentally induced pruritus including skin prick testing (SPT) with histamine or capsaicin and application of cowhage spicules. SPT as a method of capsaicin application was validated (...) , and the overall evaluation of sensory descriptors were recorded on a 100-mm visual analogue scale once itching had subsided.Skin prick testing with histamine and capsaicin resulted in flare reactions, which were 23% smaller for capsaicin (P < 0.001). Histamine, capsaicin and cowhage-induced pruritus, the duration of which was shorter for cowhage than for histamine (13.5 ± 1.4 vs. 8.8 ± 1.2 min, P = 0.005). Different mediators induced sensations of different intensities. Capsaicin produced less itch

2019 Journal of the European Academy of Dermatology and Venereology

12. Which patients with chronic pruritus are presented for psychological assessment by their dermatologists? Results from a consecutive sample. Full Text available with Trip Pro

Which patients with chronic pruritus are presented for psychological assessment by their dermatologists? Results from a consecutive sample. Chronic pruritus (CP) is a frequent symptom that poses special diagnostic and therapeutic challenges for dermatologists. To identify the causes underlying CP, a comprehensive multidisciplinary assessment is necessary1,2 . CP can impair life quality and can be associated with clinically relevant depression and anxiety levels; also, a psychiatric comorbidity (...) can be present independent of CP, but it may affect its dermatological management1,3,4 . However, not all CP patients undergo a psychological assessment. It remains unclear which individual variables of CP patients would suggest a referral for a psychological assessment by their dermatologists. We sought to investigate this relationship in a large sample of CP patients attending the Center for Chronic Pruritus (KCP) at the University of Münster. Between 2007 and 2016, data from 6,374 consecutive

2019 British Journal of Dermatology

13. Infectious differential diagnosis of chronic generalized pruritus without primary cutaneous lesions: a review of the literature. (Abstract)

dermatological findings are observed, the physician easily comes to a diagnosis and treats the condition, whereas, when primary lesions are not detected, the diagnosis can become challenging, and some patients have to undergo extensive evaluations. The association between some systemic disorders and chronic generalized pruritus is widely known and confirmed. Many infections have been associated with pruritus, but few are considered to cause chronic generalized pruritus without any characteristic skin lesions (...) . We aimed to gather all the available data on infectious causes of chronic generalized pruritus with no diagnostic cutaneous lesions to assist fellow physicians in the process of evaluation of these challenging cases.© 2019 The International Society of Dermatology.

2019 International Journal of Dermatology

14. Pruritus in Patients Under Targeted Anticancer Therapy: A Multidimensional Analysis Using the 5-D itch Scale. Full Text available with Trip Pro

receiving EGFRIs suffer from severe pruritus frequently. They not only experienced long lasting and intense itching, causing sleep discomfort, but also developed itching at specific body sites. (...) Pruritus in Patients Under Targeted Anticancer Therapy: A Multidimensional Analysis Using the 5-D itch Scale. Pruritus is a very common symptom in patients, undergoing targeted anticancer therapy. However, the characteristics of pruritus, according to the targeted anticancer agents, are still unclear. The objective of this study was to determine the characteristics of pruritus, induced by targeted anticancer agents, using a questionnaire-based survey. The survey was administered to cancer

2019 Acta Dermato-Venereologica

15. Evaluation of Cholestyramine 15% Ointment in Relieving Pruritus and Burning After Ileostomy: A Rrandomized, Double-Blind Placebo-Controlled Clinical Trial. (Abstract)

Evaluation of Cholestyramine 15% Ointment in Relieving Pruritus and Burning After Ileostomy: A Rrandomized, Double-Blind Placebo-Controlled Clinical Trial. Purpose/Aims: Skin irritation is a common ileostomy problem that causes burning and pruritus among patients due to the leakage of intestinal discharge around the stoma. This clinical trial was performed to evaluate the efficacy of topical cholestyramine (15%) on the reduction of the levels of burning and pruritus after an ileostomy.The (...) patients were randomly divided into two groups of treatment and control (n = 15). The intervention group was subjected to one fingertip of cholestyramine, whereas the other group received the placebo ointment (approximately 0.5 g) on the skin immediately after the surgery and twice a day for 2 months. The primary outcome measure was the severity of burning and pruritus measured by a visual analog scale at different times after an ileostomy.Out of 34 patients, four cases were excluded due

2019 Journal of investigative surgery : the official journal of the Academy of Surgical Research Controlled trial quality: uncertain

16. Defining the role of mirtazapine in the treatment of refractory pruritus. (Abstract)

Defining the role of mirtazapine in the treatment of refractory pruritus. Background/Objective: Mirtazapine has traditionally been used for the treatment of major depressive disorder, with an added benefit in patients who have comorbid insomnia or anxiety. Recent studies describe its usefulness in treating refractory pruritus of various causes as well. Our goal is to better define the use of mirtazapine in the treatment of refractory pruritus. Method: Through a thorough literature review (...) of PubMed, we identified all reports of the use of mirtazapine for pruritus. Results: Upon examination of 8 supporting articles, we found mirtazapine has quality evidence for the treatment of intra-thecal morphine-induced pruritus. Mirtazapine may also be effective in treating pruritus related to various other conditions, including psoriasis, atopic dermatitis, cutaneous malignancies (primary or metastatic), hematologic malignancies (lymphomas and leukemias), liver failure, renal failure, cholestasis

2019 Journal of Dermatological Treatment

17. Pruritus in ordinary scabies: IL-31 from macrophages induced by overexpression of thymic stromal lymphopoietin and periostin. (Abstract)

Pruritus in ordinary scabies: IL-31 from macrophages induced by overexpression of thymic stromal lymphopoietin and periostin. Scabies is a common contagious skin disease caused by an infestation of the skin by Sarcoptes scabiei var. hominis. A hallmark symptom of scabies is severe itch.We sought to determine the generation of a pruritogenic cytokine, interleukin (IL)-31, together with immune profiles in skin lesions of ordinary scabies through immunohistochemical and immunofluorescent studies

2019 Allergy

18. European S2k Guideline on Chronic Pruritus. Full Text available with Trip Pro

European S2k Guideline on Chronic Pruritus. Pruritus is a frequent symptom in medicine. Population-based studies show that every 5th person in the general population has suffered from chronic pruritus at least once in the lifetime with a 12-month incidence of 7%. In patient populations its frequency is much higher depending on the underlying cause, ranging from around 25% in haemodialysis patients to 100% in skin diseases such as urticaria and atopic dermatitis (AD). Pruritus may be the result (...) of a dermatological or non-dermatological disease. Especially in non-diseased skin it may be caused by systemic, neurological or psychiatric diseases, as well as being a side effect of medications. In a number of cases chronic pruritus may be of multifactorial origin. Pruritus needs a precise diagnostic work-up. Management of chronic pruritus comprises treatment of the underlying disease and topical treatment modalities, including symptomatic antipruritic treatment, ultraviolet phototherapy and systemic treatment

2019 Acta Dermato-Venereologica

19. Pruritus vulvae

Pruritus vulvae Pruritus vulvae - NICE CKS Share Pruritus vulvae: Summary Pruritus vulvae is itching of the vulva (which includes the mons pubis, labia majora, labia minora, clitoris, perineum and the external openings of the urethra and vagina). It is a symptom which is common to many conditions. An underlying cause can usually be identified from the history and examination. These include: Dermatological conditions. Infections and infestations. Neoplastic conditions. Hormonal changes (atrophic (...) vulvae should be advised to avoid: Washing with water only or with soap as these cause dry skin and make itching worse. Contact of the vulval skin with shampoo, bubble bath, vaginal washes, or wet wipes. Tight-fitting garments or synthetic clothes. Fabric conditioner or biological washing powder. Spermicidally-lubricated condoms. Coloured toilet paper. Underlying causes of pruritus vulvae should be managed appropriately. The aim of treatment is to provide symptomatic relief, reduce inflammation

2017 NICE Clinical Knowledge Summaries

20. Systemic Mastocytosis Causing Refractory Pruritus in a Liver Disease Patient Full Text available with Trip Pro

Systemic Mastocytosis Causing Refractory Pruritus in a Liver Disease Patient Systemic mastocytosis (SM) results from clonal, neoplastic proliferation of abnormal mast cells. Patients become susceptible to itching, urticaria, and anaphylactic shock, which occurs due to histamine release from mast cells. SM may coexist alongside other systemic diseases, thus confounding the overall clinical presentation. We discuss a 23-year-old woman with refractory pruritus, which was initially attributed (...) to primary sclerosing cholangitis but had a nonresponse to antihistaminics, ursodiol, and cholestyramine. Concurrent evaluation for polyarthritis revealed increased uptake in the proximal femur on a bone scan, and subsequent bone marrow biopsy revealed indolent SM, and this was understood to be the cause of her intractable pruritus.

2016 ACG case reports journal

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