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Pruritus Ani

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2. RDD1609 as a Treatment for Idiopathic Pruritus Ani

RDD1609 as a Treatment for Idiopathic Pruritus Ani RDD1609 as a Treatment for Idiopathic Pruritus Ani - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. RDD1609 as a Treatment for Idiopathic Pruritus Ani (...) by (Responsible Party): RDD Pharma Ltd Study Details Study Description Go to Brief Summary: This is a double-blind, randomized, placebo-controlled, crossover trial, to test the hypothesis that RDD1609 is effective in treating idiopathic pruritus ani. Condition or disease Intervention/treatment Phase Idiopathic Pruritus Ani Drug: RDD1609 Drug: Mebendazole 100 MG Phase 2 Detailed Description: This is a phase 2a randomized double-blinded placebo-controlled cross-over design study in patients with idiopathic

2018 Clinical Trials

3. Pruritus ani and perianal eczema as a manifestation of systemic contact dermatitis Full Text available with Trip Pro

Pruritus ani and perianal eczema as a manifestation of systemic contact dermatitis 28507498 2018 11 13 1642-395X 34 2 2017 Apr Postepy dermatologii i alergologii Postepy Dermatol Alergol Pruritus ani and perianal eczema as a manifestation of systemic contact dermatitis. 174-176 10.5114/ada.2017.67085 Hadasik Karolina K Department of Dermatology, School of Medicine, Medical University of Silesia, Katowice, Poland. Bergler-Czop Beata B Department of Dermatology, School of Medicine, Medical

2017 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

4. Pruritus

neurons firing action potentials with origins at any point along the afferent pathway (Twycross, Greaves et al. 2003, Oaklander 2012). In most cases, this is better described as neuropathic pruritus inducing an overlap of pain, pruritus and par- or dysaesthetic sensations. Somatoform pruritus is defined as pruritus where psychic, psychiatric and psychosomatic factors play a critical role in the onset, intensity, aggravation or persistence of the pruritus. 3 Epidemiology of chronic pruritus Data (...) peaks in the evening and night, frequently presenting without any primary skin lesion but sometimes with secondary scratch lesions and CPG. It is often generalised, affecting palms and soles in the early stage (Cacoub, Poynard et al. 1999). It has recently been shown that increased serum autotaxin (ATX) [the enzyme that metabolises lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA)] levels, and thereby increased LPA levels, are specific for pruritus in cholestasis, including intrahepatic

2019 European Dermatology Forum

5. Pruritus Ani

Pruritus Ani Pruritus Ani Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pruritus Ani Pruritus Ani Aka: Pruritus Ani From Related (...) compounding - dilute standard in white paraffin VIII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Pruritus Ani." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Pruritus Ani (C0033775) Definition (MSH) Intense chronic itching in the anal area. Concepts Sign or Symptom ( T184 ) MSH ICD9 698.0 ICD10 SnomedCT 201012005 , 156381007

2018 FP Notebook

6. British Association of Dermatologists? guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis

and verbal rating scale. 18 The use of a patient-completed 10-cm VAS and perhaps the Dermatology Life Quality Index 19 is rec- ommended to provide a baseline measure of itch activity to help quantify management outcomes. However, as yet, there is no international consensus on how to measure the severity of itch. 20 Moreover, there may be differences in how patients and physicians assess the severity of pruritus. 21–23 The management of pruritus depends on the treatment of any underlying disease (...) cancers. 72 This ?nding was complemented by a cohort that recently found that the risk of manifesting any malignancy was signi?cantly higher in the ?rst 3 months after developing itch. 73 Pruritus with systemic symp- toms of malignancy needs tailored investigations to rule out speci?c malignancies. Thus, in those with persistent sudden onset of severe pruritus, in the absence of any obvious trigger or other symptoms or signs or abnormal basic investigations, it may be appropriate to consider

2018 British Association of Dermatologists

7. Pruritus ani

Pruritus ani Pruritus ani - NICE CKS Share Pruritus ani: Summary Pruritus ani is a skin condition characterized by the sensation of perianal itching or burning. It is a symptom, not a diagnosis, and it can be categorized as primary (idiopathic) or secondary (has a specific underlying cause). Primary pruritus ani is thought to be functional or psychological in nature: Functional pruritus ani — a small amount of faecal loss (anorectal dysfunction) causes itching and perianal erythema (...) . Psychological pruritus ani — itching is associated with psychosomatic or psychiatric disorders (such as depression). Secondary pruritus ani has many possible causes, including: Skin conditions, such as dermatitis and psoriasis. Infections and infestations, such as a staphylococcal infections (which may also present with anal discharge) and scabies. Colorectal and anal pathology, such as anal fissure and haemorrhoids (which may also present with perianal pain and bleeding) and colorectal cancer (which may

2016 NICE Clinical Knowledge Summaries

8. Clinical interpretation of the Uremic Pruritus in Dialysis Patients (UP-Dial) scale: a novel instrument for the assessment of uremic pruritus. (Abstract)

Clinical interpretation of the Uremic Pruritus in Dialysis Patients (UP-Dial) scale: a novel instrument for the assessment of uremic pruritus. The Uremic Pruritus in Dialysis Patients (UP-Dial) scale is valid and reliable for uremic pruritus (UP) assessment. However, it remains unknown how the scores should be interpreted in clinical practices.To establish a clinical interpretation of the UP-Dial by identifying severity cut-off scores according to the disease severity and burden (...) was 0.80 (mild; 95% CI, 0.75-0.86), 0.66 (moderate; 0.60-0.71) and 0.83 (severe; 0.77-0.89). In subgroup analysis according to patient characteristics, we did not find any significant difference.The estimated UP-Dial severity band can facilitate the interpretation of UP in practice-based research settings and can be used to support treatment decisions.© 2017 European Academy of Dermatology and Venereology.

2017 Journal of the European Academy of Dermatology and Venereology

9. Pruritus Ani Full Text available with Trip Pro

Pruritus Ani Pruritus ani is a common condition with many different potential causes. Because of this, it can be difficult to treat. It is important to identify and eliminate any inciting factors, which are often unintentional consequences of the patient's attempts to alleviate symptoms. If no reversible cause is found, simple measures with diet modification and perianal hygiene are tried before using topical medications or procedures.

2016 Clinics in Colon and Rectal Surgery

10. Pharmacological interventions for pruritus in adult palliative care patients. (Abstract)

in the treatment of pruritus of different origins. Nevertheless, an optimal therapy for pruritus is constrained due to the limited understanding of crucial itch mediators and receptors in the various subforms of itch. Ideal antipruritic therapies are still lacking, especially for palliative care patients.This systematic review also indicates that there is insufficient evidence to give any concrete recommendations regarding treatment of pruritus in palliative care patients. Due to the very small sample sizes (...) Pharmacological interventions for pruritus in adult palliative care patients. Pruritus is not the most prevalent but one of the most puzzling symptoms in palliative care patients. It can cause considerable discomfort and has a major impact on patients' quality of life. In the field of palliative care, pruritus is a symptom occurring in patients with disparate underlying diseases and based on different pathologic mechanisms but ending in the same phenomenon. The pathogenesis of pruritus

2013 Cochrane

11. Sleep disturbance among Malaysian patients with end-stage renal disease with pruritus. Full Text available with Trip Pro

Sleep disturbance among Malaysian patients with end-stage renal disease with pruritus. Chronic kidney disease-associated pruritus (CKD-aP) is a well-recognized, frequent and compromising complication among patients on hemodialysis. Despite advancement in basic medical sciences, CKD-aP is still a major complication and a challenge for both physicians and patients to manage. The aim of this study was to estimate the prevalence of CKD-aP among hemodialysis patients in Malaysia, to determine (...) the impact of CKD-aP on sleep quality and any factors associated with CKD-aP.A multi-centered, cross-sectional study design was conducted from February 2017 to September 2017 at a tertiary hospital and its affiliated dialysis centers, in Kuala Lumpur, Malaysia. Included were patients > 18 years of age who were undergoing hemodialysis and could understand Malay. Participants were asked to fill the Malay 5D-itch scale and the Malay Pittsburgh sleep quality index (PSQI) upon recruitment.A total of 334/334

2019 BMC Nephrology

12. Comparison of Sertraline with Rifampin in the treatment of Cholestatic Pruritus: A Randomized Clinical Trial. (Abstract)

between the two groups (Pvalue˂0.01).There is no difference between sertraline and rifampin in pruritus improvement, but sertraline has less adverse effects on hepatobiliary enzyme levels, so it seems to be safer than rifampin.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. (...) Comparison of Sertraline with Rifampin in the treatment of Cholestatic Pruritus: A Randomized Clinical Trial. Pruritus is one of the most common and disabling symptoms of liver disease such as Primary Sclerosing Cholangitis and Primary Biliary Cholangitis. Cholestyramine, rifampin, opioid antagonists, antihistaminic agents and SSRIs are used for the management of pruritus. Due to rifampin drug interactions as well as its serious side effects such as hepatotoxicity, clinicians are endeavoruing

2019 Reviews on recent clinical trials Controlled trial quality: uncertain

13. Infectious differential diagnosis of chronic generalized pruritus without primary cutaneous lesions: a review of the literature. (Abstract)

dermatological findings are observed, the physician easily comes to a diagnosis and treats the condition, whereas, when primary lesions are not detected, the diagnosis can become challenging, and some patients have to undergo extensive evaluations. The association between some systemic disorders and chronic generalized pruritus is widely known and confirmed. Many infections have been associated with pruritus, but few are considered to cause chronic generalized pruritus without any characteristic skin lesions (...) Infectious differential diagnosis of chronic generalized pruritus without primary cutaneous lesions: a review of the literature. Pruritus is one of the most common complaints among patients referred to a dermatology clinic. "Chronic generalized pruritus" is described as the sensation of itching on the entire body surface, which lasts at least 6 or more weeks. This symptom can be a disabling phenomenon for patients and may sometimes interfere with daily activities such as sleep. If specific

2019 International Journal of Dermatology

14. Pruritus vulvae

on the underlying cause (if any). If correctly diagnosed, most underlying causes can be successfully treated. Some women may require prolonged and repeated courses of treatment to control their symptoms, depending on the underlying cause (for example lichen sclerosus is a chronic inflammatory condition that usually requires long-term treatment with topical corticosteroids to control symptoms). [ ; ] Complications What are the complications? Complications may result from: The underlying cause of the pruritus (...) : a practical approach to evaluation and management [ ], and Recognition and management of vulvar dermatologic conditions: lichen sclerosus, lichen planus, and lichen simplex chronicus [ ]. Systemic conditions What systemic conditions may cause pruritus vulvae? Any cause of generalized pruritus may cause vulvar pruritus, including: Drug reactions, for example tetracycline antibiotics, such as doxycycline, and nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen. Systemic diseases, such as renal

2017 NICE Clinical Knowledge Summaries

15. A Study of the Efficacy and Safety of Orvepitant in Subjects With Pruritus Associated With Atopic Dermatitis

Subjects must have chronic (> 6 months) pruritus which is unresponsive or inadequately responsive to current therapies such as topical steroids or antihistamines Subjects must have atopic dermatitis with a severity > 3 on the IGA and EASI ≥12 at Screening visit/Visit 1 Key Exclusion Criteria: Presence of, or history of, any other inflammatory dermatosis or skin conditions which may cause pruritus Any other possible cause for pruritus eg systemic, neurological, idiopathic, or metabolic Acute super (...) A Study of the Efficacy and Safety of Orvepitant in Subjects With Pruritus Associated With Atopic Dermatitis A Study of the Efficacy and Safety of Orvepitant in Subjects With Pruritus Associated With Atopic Dermatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2018 Clinical Trials

16. Safety, Tolerability and Efficacy of SNA-120 for Treatment of Pruritus and Psoriasis in Subjects Treated With Calcipotriene

Safety, Tolerability and Efficacy of SNA-120 for Treatment of Pruritus and Psoriasis in Subjects Treated With Calcipotriene Safety, Tolerability and Efficacy of SNA-120 for Treatment of Pruritus and Psoriasis in Subjects Treated With Calcipotriene - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety, Tolerability and Efficacy of SNA-120 for Treatment of Pruritus and Psoriasis in Subjects Treated With Calcipotriene The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03448081 Recruitment Status

2018 Clinical Trials

17. Study of the Long Term Safety of Serlopitant for the Treatment of Pruritus (Itch)

Study of the Long Term Safety of Serlopitant for the Treatment of Pruritus (Itch) Study of the Long Term Safety of Serlopitant for the Treatment of Pruritus (Itch) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Study of the Long Term Safety of Serlopitant for the Treatment of Pruritus (Itch) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03540160 Recruitment Status : Recruiting First Posted : May 30, 2018 Last Update

2018 Clinical Trials

18. Aquagenic Pruritus in Polycythemia Vera: Clinical Characteristics. Full Text available with Trip Pro

intensity, localization, quality, descriptors) and the most common factors responsible for its aggravation or alleviation were examined. Aquagenic pruritus was observed in 41.2% of individuals, mean duration 6.6 ± 8.6 years, and its onset was noticed in the majority of patients (52.4%) before the diagnosis of polycythemia vera. The mean intensity of aquagenic pruritus was 4.8 ± 1.9 points (visual analogue scale). One-third of patients with aquagenic pruritus avoided any contact with water. Antipruritic (...) Aquagenic Pruritus in Polycythemia Vera: Clinical Characteristics. Aquagenic pruritus is one of the main clinical features of polycythemia vera. The aim of this study was to analyse the clinical characteristics of aquagenic pruritus. The study group comprised 102 patients with molecularly confirmed polycythemia vera. Demographic data, data on disease history, polycythemia vera status and treatment modalities were collected. Moreover, various clinical features of aquagenic pruritus (including

2018 Acta Dermato-Venereologica

19. Elevated serum alkaline phosphatase · generalized pruritus · Dx? (Abstract)

Elevated serum alkaline phosphatase · generalized pruritus · Dx? A 34-year-old woman was referred to the hepatology clinic for evaluation of an increased serum alkaline phosphatase (ALP) level. She was gravida 5 and in her 38th week of gestation. Her obstetric history was significant for 2 uncomplicated spontaneous term vaginal deliveries resulting in live births and 2 spontaneous abortions. The patient reported generalized pruritus for 2 months prior to the visit. She had no comorbidities (...) and denied any other symptoms. She reported no family history of liver disease or complications during pregnancy in relatives. The patient did not smoke or drink, and had come to our hospital for her prenatal care visits. The physical exam revealed normal vital signs, no jaundice, a gravid uterus, and acanthosis nigricans on the neck and axilla with scattered excoriations on the arms, legs, and abdomen. Her serum ALP level was 1093 U/L (normal: 50-136 U/L). Immediately before this pregnancy, her serum

2018 Journal of Family Practice

20. Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Prurigo Nodularis

Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Prurigo Nodularis Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Prurigo Nodularis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Prurigo Nodularis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2018 Clinical Trials

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