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Proteinuria in Children

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1. Albuminuria, Proteinuria, and Renal Disease Progression in Children with CKD. Full Text available with Trip Pro

Albuminuria, Proteinuria, and Renal Disease Progression in Children with CKD. The role of albuminuria as an indicator of progression has not been investigated in children with CKD in the absence of diabetes.Children were enrolled from 49 centers of the CKD in Children study between January of 2005 and March of 2014. Cross-sectional multivariable linear regression (n=647) was used to examine the relationship between urine protein-to-creatinine (UP/C [milligrams per milligram]) and albumin (...) /mg], RT=0.38 for ACR [56-1333 mg/g], RT=0.31 for Unon-alb/cr [118-715 mg/g]) and the highest (RT=0.08 for UP/C [>2.0 mg/mg], RT=0.09 for ACR [>1333 mg/g], RT=0.07 for Unon-alb/cr [>715 mg/g]) levels to the lowest levels. A similar trend was seen when categories were created on the basis of clinically meaningful cutoff values of ACR (<30, 30-300, >300 mg/g).In children with CKD without diabetes, the utility of an initial UP/C, ACR, and Unon-alb/cr for characterizing progression

2017 Clinical Journal of the American Society of Nephrology

2. A Pediatric Patient With Ascites, Proteinuria, and Thrombocytopenia: A Rare Presentation for a Common Illness. (Abstract)

A Pediatric Patient With Ascites, Proteinuria, and Thrombocytopenia: A Rare Presentation for a Common Illness. A 7-year-old female patient presented to our pediatric emergency department with 5 days of fever, sore throat, abdominal pain, vomiting, headache, and 2 days of periorbital swelling. Her initial laboratory evaluation revealed a negative monospot test, neutropenia, atypical lymphocytosis, and thrombocytopenia in addition to transaminitis and proteinuria. An abdominal ultrasound obtained

2019 Pediatric Emergency Care

3. Albuminuria: population epidemiology and concordance in Australian children aged 11-12 years and their parents. Full Text available with Trip Pro

Albuminuria: population epidemiology and concordance in Australian children aged 11-12 years and their parents. To describe the distribution of albuminuria among Australian children aged 11-12 years and their parents, and assess its intergenerational concordance within parent-child dyads.Population-based cross-sectional study (the Child Health CheckPoint), nested within the Longitudinal Study of Australian Children.Assessment centres (seven Australian cities and eight regional towns) and home (...) -child concordance, using log-transformed data due to skewing. Survey weights and methods were applied to account for the complex sample design.The median ACR for children was 1.03 mg/mmol (IQR 0.65-1.97) and 1.01 mg/mmol (IQR 0.60-2.09) for adults. The median ACR was higher in girls (1.20, IQR 0.71-2.65) than boys (0.90, IQR 0.61-1.65) and in mothers (1.13, IQR 0.63-2.33) than fathers (0.66, IQR 0.41-1.05). Albuminuria was detected in 15.1% of children (girls 20.8%, boys 10.1%) and 13.5% of adults

2019 BMJ open

4. Children with sickle cell anemia and APOL1 genetic variants develop albuminuria early in life. Full Text available with Trip Pro

Children with sickle cell anemia and APOL1 genetic variants develop albuminuria early in life. 30890594 2019 09 08 1592-8721 104 9 2019 Sep Haematologica Haematologica Children with sickle cell anemia and APOL1 genetic variants develop albuminuria early in life. e385-e387 10.3324/haematol.2018.212779 Zahr Rima S RS Division of Pediatric Nephrology and Hypertension, University of Tennessee Health Science Center, Memphis, TN. Rampersaud Evadnie E Department of Computational Biology, St. Jude (...) Research Hospital, Memphis, TN. Estepp Jeremie H JH Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN. Lebensburger Jeffrey J Division Pediatric Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL, USA jlebensburger@peds.uab.edu. eng Letter 2019 03 19 Italy Haematologica 0417435 0390-6078 IM 2019 3 21 6 0 2019 3 21 6 0 2019 3 21 6 0 ppublish 30890594 haematol.2018.212779 10.3324/haematol.2018.212779 PMC6717565

2019 Haematologica

5. Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease. Full Text available with Trip Pro

; the study reported a decrease of 8 mmHg in systolic pressure and 5 mmHg in diastolic and mean blood pressure.There is not enough evidence to show that the administration of ACE inhibitors is associated with a reduction of microalbuminuria and proteinuria in people with sickle cell disease, although a potential for this was seen. More long-term studies involving multiple centers and larger cohorts using a randomized-controlled design are warranted, especially among the pediatric age group. Detailed (...) Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease. Sickle cell disease is a group of disorders characterized by deformation of erythrocytes. Renal damage is a frequent complication in sickle cell disease as a result of long-standing anemia and disturbed circulation through the renal medullary capillaries. Due to the improvement in life expectancy of people with sickle cell disease, there has been a corresponding significant

2015 Cochrane

6. Hyperfiltration During Early Childhood Precedes Albuminuria in Pediatric Sickle Cell Nephropathy. Full Text available with Trip Pro

not yet progressed to albuminuria (P = .26). For every 1 g/dL increase in hemoglobin, the hazard ratio for developing persistent proteinuria decreased by 0.56 (95% CI: 0.3, 1.06, P = .07).Hyperfiltration precedes the development of persistent proteinuria in pediatric SCA patients. Intervention strategies should target lowering eGFR during early childhood.© 2018 Wiley Periodicals, Inc. (...) Hyperfiltration During Early Childhood Precedes Albuminuria in Pediatric Sickle Cell Nephropathy. In patients with diabetes mellitus, hyperfiltration precedes the development of albuminuria. Pediatric sickle cell anemia (SCA) patients have a high prevalence of hyperfiltration and albuminuria during early childhood and adolescence. We tested the hypothesis that hyperfiltration precedes the development of albuminuria in a longitudinal pediatric SCA cohort.We identified 91 participants with HbSS

2018 American journal of hematology

7. Febrile Proteinuria in Hospitalized Children: Characterization of Urinary Proteins Full Text available with Trip Pro

Febrile Proteinuria in Hospitalized Children: Characterization of Urinary Proteins Background: Transient proteinuria during febrile illness is a common phenomenon. Recent studies have re-examined the pathophysiology of proteinuria and new urinary markers to characterize it, including B7-1 (CD80), which is expressed also in glomerular podocytes and influences the glomerular barrier. Aim: To investigate the pattern of proteinuria in febrile non-renal diseases, including B7-1. Methods: We (...) prospectively analyzed urine samples of 44 febrile children and 28 afebrile controls for different protein components: albumin (glomerular marker), β2-microglobulin (tubular marker), uromodulin (Tamm Horsfall protein-THP, a renal endogenous protein) and B7-1. Febrile illness was characterized as focal bacterial vs. viral. Exclusion criteria were underlying renal disease, steroid treatment or urinary tract infection. Results: Elevated urine albumin (64.5 ± 10.3 vs. 17.8 ± 4 mg/g, mean ± S.E.M., p = 0.0009

2018 Frontiers in pediatrics

8. The Spectrum of Kidney Diseases in Children Associated with Low Molecular Weight Proteinuria Full Text available with Trip Pro

The Spectrum of Kidney Diseases in Children Associated with Low Molecular Weight Proteinuria Proteinuria, in addition to haematuria, is the most important laboratory parameter in patients with nephro-urological diseases. Low molecular weight proteinuria (LMWP) is of particular importance because some diseases genetic and tubulointerstitial are diagnosed based on its presence.The purpose of this study is to describe the clinical features, the course and outcome of pediatric patients with a renal (...) disease associated with LMWP.This retrospective observational study included 250 pediatric patients with various kidney diseases in which the type of proteinuria was defined by 4-20% gradient gel sodium dodecyl sulphate polyacrylamide gel (SDS-PAG) electrophoresis.Isolated LMWP was detected in 12% of patients, while mixed glomerulotubular proteinuria was detected in 18% of patients. It was detected in all patients with the Dent-1/2 disease, Lowe's syndrome and secondary Fanconi syndrome. Transient

2018 Open access Macedonian journal of medical sciences

9. Incidental Detection of Dent-2 Disease in an Infant with Febrile Proteinuria Full Text available with Trip Pro

Incidental Detection of Dent-2 Disease in an Infant with Febrile Proteinuria Febrile proteinuria is functional proteinuria and is seen as a transitory phenomenon during acute febrile illness, mainly viral infections. It is a benign phenomenon and clears promptly with resolution of the infection.In this report, we present a patient who was thought to have febrile proteinuria. Persistence of significant proteinuria after resolution of the infection prompted biochemical and genetic workup which (...) led to the diagnosis of Dent-2 disease.We recommend the use of SDS-PAGE (sodium dodecyl sulfate electropheresis) for the detection of low molecular weight proteinuria.© 2018 The Author(s) Published by S. Karger AG, Basel.

2018 Medical Principles and Practice

10. Correlation between endocapillary proliferative and nephrotic-range proteinuria in children with Henoch-Schönlein purpura nephritis. (Abstract)

Correlation between endocapillary proliferative and nephrotic-range proteinuria in children with Henoch-Schönlein purpura nephritis. The endocapillary proliferative (EP) lesion is not included in the International Study of Kidney Disease in Children (ISKDC) pathological classification of Henoch-Schönlein purpura nephritis (HSPN). The main objective of the study was to determine the pathological importance of EP in the development of proteinuria in children with Henoch-Schönlein purpura (...) nephritis (HSPN).The pathological features of 148 HSPN children with nephrotic-range proteinuria were investigated retrospectively. Urinary IgG, transferrin, and albumin levels were measured by immunonephelometry. The correlations between EP lesion and 24-h proteinuria, urinary IgG, urinary transferrin, and urinary albumin were analyzed. Renal biopsy specimens were immunohistochemically stained for nephrin and podocalyxin.Of the total 581 cases of children with HSPN who underwent renal biopsy, 148 cases

2018 Pediatric Nephrology

11. The First Report on the Frequency of Asymptomatic Proteinuria in Iranian School-aged Children Full Text available with Trip Pro

The First Report on the Frequency of Asymptomatic Proteinuria in Iranian School-aged Children Proteinuria is a well-known indicator of renal dysfunction. In this study, we evaluated the frequency of proteinuria in a sample of healthy Iranian elementary school students using both dipsticks and urine albumin-to-creatinine ratio (UACR) methods.This cross-sectional study was performed on 478 school students aged 7-9 years who were selected by multistage random cluster sampling from Isfahan city (...) of proteinuria in Iranian children. Cost-effectiveness analyses are needed to justify large screening program for detecting asymptomatic proteinuria, as a cardinal manifestation of kidney disease, in Iranian children.

2018 Advanced biomedical research

12. Monogenic Causes of Proteinuria in Children Full Text available with Trip Pro

Monogenic Causes of Proteinuria in Children Glomerular disease is a common cause for proteinuria and chronic kidney disease leading to end-stage renal disease requiring dialysis or kidney transplantation in children. Nephrotic syndrome in children is diagnosed by the presence of a triad of proteinuria, hypoalbuminemia, and edema. Minimal change disease is the most common histopathological finding in children and adolescents with nephrotic syndrome. Focal segmental sclerosis is also found (...) in children and is the most common pathological finding in patients with monogenic causes of nephrotic syndrome. Current classification system for nephrotic syndrome is based on response to steroid therapy as a majority of patients develop steroid sensitive nephrotic syndrome regardless of histopathological diagnosis or the presence of genetic mutations. Recent studies investigating the genetics of nephrotic syndrome have shed light on the pathophysiology and mechanisms of proteinuria in nephrotic

2018 Frontiers in medicine

13. Early Proteinuria Lowering by Angiotensin-Converting Enzyme Inhibition Predicts Renal Survival in Children with CKD. Full Text available with Trip Pro

Early Proteinuria Lowering by Angiotensin-Converting Enzyme Inhibition Predicts Renal Survival in Children with CKD. Background Although pharmacotherapeutic proteinuria lowering was found to be nephroprotective in adults, the predictive value of early drug-induced proteinuria reduction for long-term renal survival in pediatric CKD is unknown. We analyzed data from the ESCAPE Trial for a potential association between initial antiproteinuric effect of standardized angiotensin-converting enzyme (...) was independent of age, sex, CKD diagnosis, baseline eGFR, baseline proteinuria, initial BP, and concomitant BP reduction.Conclusions The early antiproteinuric effect of ACE inhibition is associated with long-term preservation of renal function in children with CKD. Proteinuria lowering should be considered an important target in the management of pediatric CKD.Copyright © 2018 by the American Society of Nephrology.

2018 Journal of the American Society of Nephrology Controlled trial quality: uncertain

14. Albumin:creatinine ratio testing in the assessment and/or identification of proteinuria in people with chronic kidney disease or primary hypertension

with CKD or hypertension at risk of kidney damage who require proteinuria testing People with diabetes at risk of CKD, pregnancy, children (<18 years), people with secondary hypertension Intervention Urine ACR Comparison/ comparators Urine PCR Outcomes CKD progression, measured by: change in eGFR occurrence of end stage kidney disease acute kidney injury initiation of renal replacement therapy All-cause mortality Cardiovascular mortality Diagnostic accuracy outcomes Study design Randomised or non (...) proteinuria and albuminuria. Qjm, 104(8), 663-670. doi:https://dx.doi.org/10.1093/qjmed/hcr026 Ying, T., Clayton, P., Naresh, C., & Chadban, S. (2018). Predictive value of spot versus 24-hour measures of proteinuria for death, end-stage kidney disease or chronic kidney disease progression. BMC Nephrology, 19(1), 55. doi:https://dx.doi.org/10.1186/s12882-018-0853-1 Zhao, Y. F., Zhu, L., Liu, L. J., Shi, S. F., Lv, J. C., & Zhang, H. (2016). Measures of Urinary Protein and Albumin in the Prediction

2019 Health Technology Wales

15. Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease. (Abstract)

Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease. Sickle cell disease is a group of disorders characterized by deformation of erythrocytes. Renal damage is a frequent complication in sickle cell disease as a result of long-standing anemia and disturbed circulation through the renal medullary capillaries. Due to the improvement in life expectancy of people with sickle cell disease, there has been a corresponding significant (...) increase in the incidence of renal complications. Microalbuminuria and proteinuria are noted to be a strong predictor of subsequent renal failure. There is extensive experience and evidence with angiotensin-converting enzyme (ACE) inhibitors over many years in a variety of clinical situations for patients who do not have sickle cell disease, but their effect in patients with this disease is unknown. It is common practice to administer ACE inhibitors for sickle nephropathy due to their renoprotective

2013 Cochrane

16. CoQ10-related sustained remission of proteinuria in a child with COQ6 glomerulopathy-a case report. Full Text available with Trip Pro

CoQ10-related sustained remission of proteinuria in a child with COQ6 glomerulopathy-a case report. Treatment of steroid resistant nephrotic syndrome is still a challenge for physicians. There are a growing number of studies exploring genetic background of steroid-resistant glomerulopathies.We present the case of a 4-year-old girl with steroid-resistant glomerulopathy due to a COQ6 defect with no additional systemic symptoms. The disease did not respond for second-line therapy with calcineurin (...) inhibitor, but it remitted completely after oral treatment with 30 mg/kg/d of coenzyme Q10 (CoQ10). The patient was identified to be a compound heterozygote for two pathogenic variants in COQ6 gene: a known missense substitution c.1078C > T (p.R360W) and a novel frameshift c.804delC mutation. After 12 months of CoQ10 therapy, the child remains in full remission, her physical development accelerated, frequent respiratory airways diseases subsided.Genetic assessment of children with steroid-resistant

2018 Pediatric Nephrology

17. Prevalence of Albuminuria in Children Living in a Rural Agricultural and Fishing Subsistence Community in Lake Chapala, Mexico Full Text available with Trip Pro

Prevalence of Albuminuria in Children Living in a Rural Agricultural and Fishing Subsistence Community in Lake Chapala, Mexico The occurrence of Chronic Kidney Disease (CKD) of unknown etiology in autochthonous child populations residing along the Lake Chapala lakeshore is endemic (Jalisco, México). The objective of this study was to determine the prevalence of albuminuria in the pediatric population and to measure the glomerular filtration rate in children with two positive albuminuria tests (...) . Urinary albumin was measured in 394 children. Subjects with two or more positive albuminuria test donated blood samples for the determination of serum biomarkers. From a rural community with 565 children under the age of 17 years, 394 (69.7%) participated with first morning urine samples. A total of 180 children were positive (with two or more positive albuminuria tests). The prevalence of albuminuria among the children participating in the study was 45.7%. Of the 180 children with persistent

2017 International journal of environmental research and public health

18. A lack of association between vitamin D-binding protein and 25-hydroxyvitamin D concentrations in pediatric type 1 diabetes without microalbuminuria Full Text available with Trip Pro

A lack of association between vitamin D-binding protein and 25-hydroxyvitamin D concentrations in pediatric type 1 diabetes without microalbuminuria Vitamin D deficiency is reported to be more common in type 1 diabetes patients and might be associated with the increased urinary loss of vitamin D binding protein (VDBP) consequent to impaired 25-hydroxyvitamin D (25(OH)D) circulation. We aimed to evaluate the possible increased urinary loss of VDBP, a correlation between VDBP and circulating 25 (...) (OH)D level, and risk factors influencing low vitamin D level in pediatric type 1 diabetes patients without microalbuminuria.This is a cross-sectional study of subjects who visited Seoul National University Children's Hospital between January and March 2013. Forty-two type 1 diabetes patients and 29 healthy controls were included. Biochemical parameters including serum and urine VDBP concentrations were analyzed.There was no significant difference in the frequency of vitamin D deficiency or serum

2017 Annals of pediatric endocrinology & metabolism

19. The population-based prevalence of albuminuria in children. (Abstract)

The population-based prevalence of albuminuria in children. To determine the population-based prevalence of albuminuria in Australian children and validate any negative correlation with body mass index (BMI).Data from the Australian Health Survey 2011-2013 were used. This is a large-scale survey of the health of the Australian population, conducted by the Australian Bureau of Statistics, and uses a stratified, multistage area design with replicate weights attached to observations to allow (...) for the derivation of accurate population estimates. We considered children aged 5-18 years, and defined albuminuria as an albumin-to-creatinine ratio (ACR) >30 mg/g (3.4 mg/mmol).A total of 975 children provided urine samples for determination of ACR. The prevalence of albuminuria was 10.2% for males (95% confidence interval [CI] 6.1-14.2) and 15.5% for females (95% CI 10.7-20.3). After adjusting for age and gender, the odds ratio for albuminuria associated with being overweight or obese was 0.34 (95% CI 0.15

2017 Pediatric Nephrology

20. High Incidence of Proteinuria in Children with Chronic Intestinal Failure Under Long-Term Parenteral Nutrition. (Abstract)

High Incidence of Proteinuria in Children with Chronic Intestinal Failure Under Long-Term Parenteral Nutrition. Long-term home parenteral nutrition (LTPN) in children with chronic intestinal failure (CIF) is associated with renal complications such as fluid and electrolyte imbalances, nephrocalcinosis, nephrolithiasis, and chronic kidney disease (CKD). The etiology of CIF-associated nephropathy is multifactorial. The aim of this study was to evaluate renal involvement under LTPN. In this study (...) , 50 patients with CIF, median age 4.2 years (1.4-9.3; 23 girls) were included. Kidney involvement was a frequent finding in this study. CKD was present in 30% of patients without correlation with LTPN duration. Glomerular proteinuria was found in the majority of patients (76%), an important long-term risk factor for the progression of CKD. Increased urinary α-1 microglobulin was significantly associated with duration (years) of LTPN and was increased in patients with CKD.

2017 Journal of Pediatric Gastroenterology and Nutrition

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