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Prostaglandin Gel

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1. Prostaglandin vaginal gel induction of labor comparing amniotomy with repeat prostaglandin gel Full Text available with Trip Pro

Prostaglandin vaginal gel induction of labor comparing amniotomy with repeat prostaglandin gel The purpose of this study was to compare 2 inductions of labor protocols.Women with live singleton pregnancies at ≥37 + 0 weeks gestation who were booked for prostaglandins 2 (PGE2) vaginal gel induction with a modified Bishop's score of <7 were eligible for inclusion. After an evening dose of PGE2 vaginal gel, women were assigned randomly the next morning into the amniotomy or repeat-PGE2 group (...) of birth or any of the secondary outcomes.After an initial dose of PGE2 vaginal gel, an amniotomy (once technically possible) is associated with a shorter induction of labor-to-birth time compared with the use of repeat doses of PGE2. Administering more PGE2 with the aim of starting contractions or making the cervix "more favorable," appears to have no clinical advantage.Copyright © 2015 Elsevier Inc. All rights reserved.

2015 EvidenceUpdates Controlled trial quality: predicted high

2. Prostaglandin gel versus oxytocin - prelabour rupture of membranes at term - A randomised controlled trial. Full Text available with Trip Pro

Prostaglandin gel versus oxytocin - prelabour rupture of membranes at term - A randomised controlled trial. Pre-labour rupture of membranes (PROM) at term is a common event with early induction of labour reducing infectious morbidity without increasing the caesarean rate. Syntocinon is commonly used for induction but prostaglandins are also routinely used. Large studies have shown no difference in the maternal and neonatal outcomes with either method.To assess the safety and efficacy of vaginal (...) prostaglandin (PG) compared to syntocinon for induction of labour in term-PROM.This was a single-centre randomised controlled trial at Ipswich Hospital of women presenting at ≥37 weeks gestation with PROM. Women were randomised and managed in labour as per local guidelines. Analysis was by intention to treat.One hundred and eighty-four women were recruited, 90 in the PG group and 94 in the oxytocin group. Women in both arms were of similar demographics and 53% of women in the PG group did not require any

2018 The Australian & New Zealand journal of obstetrics & gynaecology Controlled trial quality: predicted high

3. Measuring women's experience of induction of labor using prostaglandin vaginal gel. Full Text available with Trip Pro

Measuring women's experience of induction of labor using prostaglandin vaginal gel. To describe and examine the EXIT (EXperiences of Induction Tool), and report on the experience of women undergoing PGE2 vaginal gel IOL, who were participants in a randomized controlled trial comparing early amniotomy with repeat-PGE2.Following an evening dose of PGE2 vaginal gel, 245 women with live singleton term pregnancies were randomized to amniotomy or repeat-PGE2. Women's experience of IOL was a secondary (...) vaginal gel IOL reports a more positive experience with an early amniotomy rather than with repeat-PGE2.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

2018 European journal of obstetrics, gynecology, and reproductive biology Controlled trial quality: uncertain

4. Induction of labor using prostaglandin vaginal gel: cost analysis comparing early amniotomy with repeat prostaglandin gel. (Abstract)

Induction of labor using prostaglandin vaginal gel: cost analysis comparing early amniotomy with repeat prostaglandin gel. In a randomized controlled trial of two policies for induction of labor (IOL) using Prostaglandin E2 (PGE2) vaginal gel, women who had an earlier amniotomy experienced a shorter IOL-to-birth time.To report the cost analysis of this trial and determine if there are differences in healthcare costs when an early amniotomy is performed as opposed to giving more PGE2 vaginal gel (...) , for women undergoing IOL at term.Following an evening dose of PGE2 vaginal gel, 245 women with live singleton pregnancies, ≥37+0 weeks, were randomized into an amniotomy or repeat-PGE2 group. Healthcare costs were a secondary outcome measure, sourced from hospital finance systems and included staff costs, equipment and consumables, pharmacy, pathology, hotel services and business overheads. A decision analytic model, specifically a Markov chain, was developed to further investigate costs, and a Monte

2016 European journal of obstetrics, gynecology, and reproductive biology Controlled trial quality: uncertain

5. Vitamin A Palmitate and Carbomer Gel Protects the Conjunctiva of Patients With Long-term Prostaglandin Analogs Application. (Abstract)

Vitamin A Palmitate and Carbomer Gel Protects the Conjunctiva of Patients With Long-term Prostaglandin Analogs Application. To investigate the protective effects of vitamin A palmitate and carbomer gel on the morphology of conjunctival epithelium and density of goblet cells (GCs) in patients on long-term prostaglandin analogs (PGAs) application.In this prospective cohort study, 23 primary open-angle glaucoma patients and 7 normal-tension glaucoma patients prescribed PGAs for >1 year were (...) enrolled into 3 identical clinical trials and randomized into 3 groups (10 per group). Patients were treated twice daily with vitamin A palmitate eye gel 0.1%, or carbomer eye gel 0.2%, or no additional application of these 2 drugs. Ocular surface disease index questionnaires, Schirmer 1 test without anesthesia, tear break-up time test, and GCs density assessment by in vivo confocal microscopy and conjunctival impression cytology analysis were performed at baseline and at months 1, 3, and 6

2017 Journal of Glaucoma Controlled trial quality: uncertain

6. Predictors of mode of birth and duration of labour following induction using prostaglandin vaginal gel. (Abstract)

Predictors of mode of birth and duration of labour following induction using prostaglandin vaginal gel. Using data from a randomised controlled trial (RCT) comparing two policies of prostaglandin (PGE2) vaginal gel induction of labour (IOL) at term, this study aimed to determine: (i) demographic/clinical factors that predict IOL outcomes; and (ii) clinical characteristic(s) of women who would benefit from a policy of amniotomy once technically possible as opposed to giving more PGE2.Following (...) , there was no scenario where repeat PGE2 was predicted to be superior to an earlier amniotomy.Following IOL using PGE2 vaginal gel at term, both parity and cervical favourability at first review are associated with CS and VD < 24 h. All combinations of parity and MBS at first review predicted fewer CS and greater likelihood of VD < 24 h with a policy of amniotomy once technically possible.© 2017 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.

2017 The Australian & New Zealand journal of obstetrics & gynaecology Controlled trial quality: uncertain

7. Prostaglandin Gel

Prostaglandin Gel Prostaglandin Gel Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Prostaglandin Gel Prostaglandin Gel Aka (...) : Prostaglandin Gel , Dinoprostone , PGE2 Gel , Cervidil , Prepidil From Related Chapters II. Indications <6 Membranes intact No active contraction pattern Less than 10 mild contractions per hour III. Medication: Dinoprostone Gel (PGE2 Gel, Prepidil) Initiate and tocometry Start 15-30 minutes before gel inserted Continue monitoring for 30-120 minutes after Insertion Technique Use one syringe of gel (0.5 mg in 3cc KY) Introduce gel into not effaced: Use 20 mm catheter effaced 50% or greater: Use 10 mm catheter

2018 FP Notebook

8. Cost-effectiveness analysis of prostaglandin E2 gel for the induction of labour at term

Cost-effectiveness analysis of prostaglandin E2 gel for the induction of labour at term Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 NHS Economic Evaluation Database.

9. Flowchart: Induction of labour, Prostaglandin E2 (Dinoprostone) (PDF, 118kB)

assessment · Encourage to empty bladder Induction of labour See flowchart: Method of induction ARM successful? or SROM? Prostaglandin E 2 (dinoprostone) Dinoprostone GEL · Nulliparous: 2 mg PV · Multiparous: 1 mg PV · Insert high into posterior fornix · Wait at least 6 hours after insertion then reassess MBS Dinoprostone PESSARY · 10 mg PV · Position transversely in posterior fornix · Wait at least 12 hours after insertion then reassess MBS If GEL used: · May repeat to maximum of 3 doses at least 6 hours (...) Flowchart: Induction of labour, Prostaglandin E2 (Dinoprostone) (PDF, 118kB) Queensland Health State of Queensland (Queensland Health) 2018 http://creativecommons.org/licenses/by-nc-nd/3.0/au/deed.en Queensland Clinical Guidelines, Guidelines@health.qld.gov.au Queensland Clinical Guidelines www.health.qld.gov.au/qcg Prostaglandin E2 (dinoprostone) for induction of labour Queensland Clinical Guideline: Induction of labour. Flowchart: F17.22-3-V6-R22 Pre dinoprostone insertion · Complete pre IOL

2017 Queensland Health

10. Cost-effectiveness of term induction of labour using inpatient prostaglandin gel versus outpatient Foley catheter. (Abstract)

Cost-effectiveness of term induction of labour using inpatient prostaglandin gel versus outpatient Foley catheter. Evaluating cost-effectiveness of induction of labour (IOL) using outpatient mechanical cervical ripening using a Foley catheter (OFC) compared to inpatient chemical ripening using prostin gel (IPG).Cost-effectiveness analysis from a hospital perspective alongside a RCT. Women in a metropolitan Australian maternity hospital with an unfavourable cervix requiring IOL at term were

2015 The Australian & New Zealand journal of obstetrics & gynaecology Controlled trial quality: uncertain

11. Prostaglandins before caesarean section for preventing neonatal respiratory distress. Full Text available with Trip Pro

centre in Australia. The study involved 36 women (18 received intravaginal prostaglandin E 2 gel and 18 received placebo).There was one case of neonatal respiratory distress in the control group, which the trialist reported as transient tachypnoea of the newborn (risk ratio (RR) 0.33, 95% confidence interval (CI) 0.01 to 7.68, one study, n = 36).None of the neonates required mechanical ventilation and the trial authors reported median Apgar scores at one and five minutes as being similar in both (...) Prostaglandins before caesarean section for preventing neonatal respiratory distress. Respiratory distress (RD) can occur in both preterm and term neonates born through normal vaginal delivery or caesarean section (CS). It accounts for about 30% of neonatal deaths and can occur at any time following birth. Respiratory distress syndrome (RDS), transient tachypnoea (rapid breathing) of the newborn and persistent pulmonary hypertension (increased blood pressure of pulmonary vessels) of the newborn

2013 Cochrane

12. Effect of chlorella supplementation on systematic symptoms and serum levels of prostaglandins, inflammatory and oxidative markers in women with primary dysmenorrhea. (Abstract)

Effect of chlorella supplementation on systematic symptoms and serum levels of prostaglandins, inflammatory and oxidative markers in women with primary dysmenorrhea. Primary dysmenorrhea is one of the most commonly reported disorders for women that have unfavorable effects on patient's quality of life. Based on the evidences that suggest the anti-inflammatory and analgesic properties of chlorella, this double-blind, randomized, placebo controlled clinical trial aimed to evaluate the effects (...) of Chlorella supplementation on the severity of menstrual pain in a group of young women with primary dysmenorrhea.In this clinical trial, 44 girls with primary dysmenorrhea were randomly divided into intervention and control groups. Patients in the intervention group received 1500 mg/day of chlorella as 5 soft gel and the control group received placebo soft gels for eight weeks. Menstrual and food information were collected using a previously validated and published questionnaire. Anthropometric

2019 European journal of obstetrics, gynecology, and reproductive biology Controlled trial quality: uncertain

13. Comparison of intracervical Foley catheter used alone or combined with a single dose of dinoprostone gel for cervical ripening: a randomised study. (Abstract)

Comparison of intracervical Foley catheter used alone or combined with a single dose of dinoprostone gel for cervical ripening: a randomised study. Prostaglandins and intracervical catheters are similarly effective for cervical ripening and for an induction of labour (IOL). Studies comparing the combined use with either method alone have administered repetitive doses of prostaglandins vaginally, which may increase the risk of tachysystole and chorioamnionitis. These disadvantages may be offset (...) by co-administering a single dose of prostaglandin. Women (n = 110) planned for IOL, ≥37 weeks of gestation and with a Bishop Score of ≤6 were randomised into two groups: intracervical Foley catheter alone or combined with dinoprostone gel (0.5 mg) for 12 hours followed by oxytocin. The primary outcome was the IDI and the others were: change in Bishop Score, caesarean section (CS) requirement, any complications and neonatal outcome. The baseline Bishop was ≤4 in all and >80% were nulliparous

2019 Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology Controlled trial quality: uncertain

14. Characterization of the Inhibitory Effects of Fevipiprant (QAW039) on Activation of Eosinophils and ILC2 Cells by Prostaglandin D2 Metabolites

Characterization of the Inhibitory Effects of Fevipiprant (QAW039) on Activation of Eosinophils and ILC2 Cells by Prostaglandin D2 Metabolites Characterization of the Inhibitory Effects of Fevipiprant (QAW039) on Activation of Eosinophils and ILC2 Cells by Prostaglandin D2 Metabolites - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Characterization of the Inhibitory Effects of Fevipiprant (QAW039) on Activation of Eosinophils and ILC2 Cells by Prostaglandin D2 Metabolites (18-03 EONOV) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2018 Clinical Trials

15. Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation. Full Text available with Trip Pro

Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation. To compare the hypotensive effect of travoprost 0.004%/timolol 0.5% fixed combination (TTFC) to the concomitant use of travoprost and timolol 0.1% gel formulation (Trav + Geltim).Thirty-three patients (62 eyes) were enrolled and divided into two groups. Patients in group 1 (31 eyes) received the TTFC and patients in group 2 (31 eyes) received the concomitant (...) treatment with Trav + Geltim. Patients on previous antiglaucoma treatment discontinued their drops for 2-4 weeks before starting their new treatment (TTFC or Trav + Geltim). The drops were instilled in the evening in group 1 and in group 2, the prostaglandin was installed in the evening, and timolol in the morning. IOP was measured at 1 and 3 months after the initiation of treatment at four time points during the day (09:00, 12:00, 15:00, and 18:00).Both groups showed significant IOP reduction from

2018 Clinical ophthalmology (Auckland, N.Z.) Controlled trial quality: uncertain

16. Outpatient Foley catheter versus inpatient prostaglandin E2 gel for induction of labour: a randomised trial. Full Text available with Trip Pro

Outpatient Foley catheter versus inpatient prostaglandin E2 gel for induction of labour: a randomised trial. Induction of labour (IOL) is one of the commonest obstetric interventions, with significant impact on both the individual woman and health service delivery. Outpatient IOL is an attractive option to reduce these impacts. To date there is little data comparing outpatient and inpatient IOL methods, and potential safety concerns (hyperstimulation) if prostaglandins, the standard inpatient

2013 BMC pregnancy and childbirth Controlled trial quality: uncertain

17. Cost-effectiveness of induction of labour at term with a Foley catheter compared to vaginal prostaglandin E2 gel (PROBAAT trial). (Abstract)

Cost-effectiveness of induction of labour at term with a Foley catheter compared to vaginal prostaglandin E2 gel (PROBAAT trial). To assess the economic consequences of labour induction with Foley catheter compared to prostaglandin E2 gel.Economic evaluation alongside a randomised controlled trial.Obstetric departments of one university and 11 teaching hospitals in the Netherlands.Women scheduled for labour induction with a singleton pregnancy in cephalic presentation at term, intact membranes (...) and an unfavourable cervix; and without previous caesarean section.Cost-effectiveness analysis from a hospital perspective.We estimated direct medical costs associated with healthcare utilisation from randomisation to 6 weeks postpartum. For caesarean section rate, and maternal and neonatal morbidity we calculated the incremental cost-effectiveness ratios, which represent the costs to prevent one of these adverse outcomes.Mean costs per woman in the Foley catheter group (n = 411) and in the prostaglandin E₂ gel

2013 BJOG Controlled trial quality: uncertain

18. Prostaglandin Gel

Prostaglandin Gel Prostaglandin Gel Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Prostaglandin Gel Prostaglandin Gel Aka (...) : Prostaglandin Gel , Dinoprostone , PGE2 Gel , Cervidil , Prepidil From Related Chapters II. Indications <6 Membranes intact No active contraction pattern Less than 10 mild contractions per hour III. Medication: Dinoprostone Gel (PGE2 Gel, Prepidil) Initiate and tocometry Start 15-30 minutes before gel inserted Continue monitoring for 30-120 minutes after Insertion Technique Use one syringe of gel (0.5 mg in 3cc KY) Introduce gel into not effaced: Use 20 mm catheter effaced 50% or greater: Use 10 mm catheter

2015 FP Notebook

19. A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities Full Text available with Trip Pro

, the brucine significantly inhibited lipopolysaccharide (LPS)-induced Prostaglandin E2 (PGE2) production without affecting the viability of cell in vitro anti-inflammatory test, which proved that its anti-inflammatory and analgesic actions were related to inhibition of prostaglandin synthesis. It is suggested that the brucine gel is a promising vehicle for transdermal delivery on the treatment of inflammatory disease. (...) A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities The seeds of Strychnosnux-vomica L., as a traditional Chinese medicine, have good anti-inflammatory and analgesic activities. However, it usually leads to gastrointestinal irritation and systemic toxicity via oral administration. In the study, it was discovered that a novel gel transdermal delivery system contained brucine, the main effective component extracted from Strychnosnux-vomica

2017 International journal of molecular sciences

20. Lidocaine In-situ Gel Prior to Intrauterine Device Insertion in Women With no Previous Vaginal Delivery

Lidocaine In-situ Gel Prior to Intrauterine Device Insertion in Women With no Previous Vaginal Delivery Lidocaine In-situ Gel Prior to Intrauterine Device Insertion in Women With no Previous Vaginal Delivery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Lidocaine In-situ Gel Prior to Intrauterine Device Insertion in Women With no Previous Vaginal Delivery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03166111

2017 Clinical Trials

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