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Prostaglandin Gel

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1. Induction of labor using prostaglandin vaginal gel: cost analysis comparing early amniotomy with repeat prostaglandin gel. (PubMed)

Induction of labor using prostaglandin vaginal gel: cost analysis comparing early amniotomy with repeat prostaglandin gel. In a randomized controlled trial of two policies for induction of labor (IOL) using Prostaglandin E2 (PGE2) vaginal gel, women who had an earlier amniotomy experienced a shorter IOL-to-birth time.To report the cost analysis of this trial and determine if there are differences in healthcare costs when an early amniotomy is performed as opposed to giving more PGE2 vaginal gel (...) , for women undergoing IOL at term.Following an evening dose of PGE2 vaginal gel, 245 women with live singleton pregnancies, ≥37+0 weeks, were randomized into an amniotomy or repeat-PGE2 group. Healthcare costs were a secondary outcome measure, sourced from hospital finance systems and included staff costs, equipment and consumables, pharmacy, pathology, hotel services and business overheads. A decision analytic model, specifically a Markov chain, was developed to further investigate costs, and a Monte

2016 European journal of obstetrics, gynecology, and reproductive biology

2. Prostaglandin vaginal gel induction of labor comparing amniotomy with repeat prostaglandin gel (PubMed)

Prostaglandin vaginal gel induction of labor comparing amniotomy with repeat prostaglandin gel The purpose of this study was to compare 2 inductions of labor protocols.Women with live singleton pregnancies at ≥37 + 0 weeks gestation who were booked for prostaglandins 2 (PGE2) vaginal gel induction with a modified Bishop's score of <7 were eligible for inclusion. After an evening dose of PGE2 vaginal gel, women were assigned randomly the next morning into the amniotomy or repeat-PGE2 group (...) of birth or any of the secondary outcomes.After an initial dose of PGE2 vaginal gel, an amniotomy (once technically possible) is associated with a shorter induction of labor-to-birth time compared with the use of repeat doses of PGE2. Administering more PGE2 with the aim of starting contractions or making the cervix "more favorable," appears to have no clinical advantage.Copyright © 2015 Elsevier Inc. All rights reserved.

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2015 EvidenceUpdates

3. Measuring women's experience of induction of labor using prostaglandin vaginal gel. (PubMed)

Measuring women's experience of induction of labor using prostaglandin vaginal gel. To describe and examine the EXIT (EXperiences of Induction Tool), and report on the experience of women undergoing PGE2 vaginal gel IOL, who were participants in a randomized controlled trial comparing early amniotomy with repeat-PGE2.Following an evening dose of PGE2 vaginal gel, 245 women with live singleton term pregnancies were randomized to amniotomy or repeat-PGE2. Women's experience of IOL was a secondary (...) vaginal gel IOL reports a more positive experience with an early amniotomy rather than with repeat-PGE2.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

2018 European journal of obstetrics, gynecology, and reproductive biology

4. Prostaglandin gel versus oxytocin - prelabour rupture of membranes at term - A randomised controlled trial. (PubMed)

Prostaglandin gel versus oxytocin - prelabour rupture of membranes at term - A randomised controlled trial. Pre-labour rupture of membranes (PROM) at term is a common event with early induction of labour reducing infectious morbidity without increasing the caesarean rate. Syntocinon is commonly used for induction but prostaglandins are also routinely used. Large studies have shown no difference in the maternal and neonatal outcomes with either method.To assess the safety and efficacy of vaginal (...) prostaglandin (PG) compared to syntocinon for induction of labour in term-PROM.This was a single-centre randomised controlled trial at Ipswich Hospital of women presenting at ≥37 weeks gestation with PROM. Women were randomised and managed in labour as per local guidelines. Analysis was by intention to treat.One hundred and eighty-four women were recruited, 90 in the PG group and 94 in the oxytocin group. Women in both arms were of similar demographics and 53% of women in the PG group did not require any

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2018 The Australian & New Zealand journal of obstetrics & gynaecology

5. Cost-effectiveness analysis of prostaglandin E2 gel for the induction of labour at term

Cost-effectiveness analysis of prostaglandin E2 gel for the induction of labour at term Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 NHS Economic Evaluation Database.

6. Predictors of mode of birth and duration of labour following induction using prostaglandin vaginal gel. (PubMed)

Predictors of mode of birth and duration of labour following induction using prostaglandin vaginal gel. Using data from a randomised controlled trial (RCT) comparing two policies of prostaglandin (PGE2) vaginal gel induction of labour (IOL) at term, this study aimed to determine: (i) demographic/clinical factors that predict IOL outcomes; and (ii) clinical characteristic(s) of women who would benefit from a policy of amniotomy once technically possible as opposed to giving more PGE2.Following (...) , there was no scenario where repeat PGE2 was predicted to be superior to an earlier amniotomy.Following IOL using PGE2 vaginal gel at term, both parity and cervical favourability at first review are associated with CS and VD < 24 h. All combinations of parity and MBS at first review predicted fewer CS and greater likelihood of VD < 24 h with a policy of amniotomy once technically possible.© 2017 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.

2017 The Australian & New Zealand journal of obstetrics & gynaecology

7. Vitamin A Palmitate and Carbomer Gel Protects the Conjunctiva of Patients With Long-term Prostaglandin Analogs Application. (PubMed)

Vitamin A Palmitate and Carbomer Gel Protects the Conjunctiva of Patients With Long-term Prostaglandin Analogs Application. To investigate the protective effects of vitamin A palmitate and carbomer gel on the morphology of conjunctival epithelium and density of goblet cells (GCs) in patients on long-term prostaglandin analogs (PGAs) application.In this prospective cohort study, 23 primary open-angle glaucoma patients and 7 normal-tension glaucoma patients prescribed PGAs for >1 year were (...) enrolled into 3 identical clinical trials and randomized into 3 groups (10 per group). Patients were treated twice daily with vitamin A palmitate eye gel 0.1%, or carbomer eye gel 0.2%, or no additional application of these 2 drugs. Ocular surface disease index questionnaires, Schirmer 1 test without anesthesia, tear break-up time test, and GCs density assessment by in vivo confocal microscopy and conjunctival impression cytology analysis were performed at baseline and at months 1, 3, and 6

2017 Journal of Glaucoma

8. Prostaglandin vaginal gel induction of labor comparing amniotomy with repeat prostaglandin gel. (PubMed)

Prostaglandin vaginal gel induction of labor comparing amniotomy with repeat prostaglandin gel. The purpose of this study was to compare 2 inductions of labor protocols.Women with live singleton pregnancies at ≥37 + 0 weeks gestation who were booked for prostaglandins 2 (PGE2) vaginal gel induction with a modified Bishop's score of <7 were eligible for inclusion. After an evening dose of PGE2 vaginal gel, women were assigned randomly the next morning into the amniotomy or repeat-PGE2 group (...) of birth or any of the secondary outcomes.After an initial dose of PGE2 vaginal gel, an amniotomy (once technically possible) is associated with a shorter induction of labor-to-birth time compared with the use of repeat doses of PGE2. Administering more PGE2 with the aim of starting contractions or making the cervix "more favorable," appears to have no clinical advantage.Copyright © 2015 Elsevier Inc. All rights reserved.

2015 American Journal of Obstetrics and Gynecology

9. Prostaglandin Gel

Prostaglandin Gel Prostaglandin Gel Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Prostaglandin Gel Prostaglandin Gel Aka (...) : Prostaglandin Gel , Dinoprostone , PGE2 Gel , Cervidil , Prepidil From Related Chapters II. Indications <6 Membranes intact No active contraction pattern Less than 10 mild contractions per hour III. Medication: Dinoprostone Gel (PGE2 Gel, Prepidil) Initiate and tocometry Start 15-30 minutes before gel inserted Continue monitoring for 30-120 minutes after Insertion Technique Use one syringe of gel (0.5 mg in 3cc KY) Introduce gel into not effaced: Use 20 mm catheter effaced 50% or greater: Use 10 mm catheter

2018 FP Notebook

10. Flowchart: Induction of labour, Prostaglandin E2 (Dinoprostone) (PDF, 118kB)

assessment · Encourage to empty bladder Induction of labour See flowchart: Method of induction ARM successful? or SROM? Prostaglandin E 2 (dinoprostone) Dinoprostone GEL · Nulliparous: 2 mg PV · Multiparous: 1 mg PV · Insert high into posterior fornix · Wait at least 6 hours after insertion then reassess MBS Dinoprostone PESSARY · 10 mg PV · Position transversely in posterior fornix · Wait at least 12 hours after insertion then reassess MBS If GEL used: · May repeat to maximum of 3 doses at least 6 hours (...) Flowchart: Induction of labour, Prostaglandin E2 (Dinoprostone) (PDF, 118kB) Queensland Health State of Queensland (Queensland Health) 2018 http://creativecommons.org/licenses/by-nc-nd/3.0/au/deed.en Queensland Clinical Guidelines, Guidelines@health.qld.gov.au Queensland Clinical Guidelines www.health.qld.gov.au/qcg Prostaglandin E2 (dinoprostone) for induction of labour Queensland Clinical Guideline: Induction of labour. Flowchart: F17.22-3-V6-R22 Pre dinoprostone insertion · Complete pre IOL

2017 Queensland Health

11. New evidence compares effectiveness of prostaglandin drugs for inducing labour

for induction of labour recommends vaginal prostaglandin E2 (PGE 2 , dinoprostone) as the preferred drug method for induction of labour unless there are specific clinical reasons for not using it, in particular the risk of uterine overstimulation. PGE 2 can be given using a pessary inserted into the vagina, a gel or tablet; no other routes are recommended. Misoprostol is not licensed in the UK for induction of labour and is only recommended by NICE for women where the foetus has died while in the uterus (...) New evidence compares effectiveness of prostaglandin drugs for inducing labour Most effective prostaglandin drugs for inducing labour Discover Portal Discover Portal New evidence compares effectiveness of prostaglandin drugs for inducing labour Published on 7 February 2015 doi: This review partly funded by the NIHR provides the largest pooling of international data on the effectiveness of prostaglandin drugs used to induce labour. It found that the most effective prostaglandin for inducing

2018 NIHR Dissemination Centre

12. New evidence compares effectiveness of prostaglandin drugs for inducing labour

for induction of labour recommends vaginal prostaglandin E2 (PGE 2 , dinoprostone) as the preferred drug method for induction of labour unless there are specific clinical reasons for not using it, in particular the risk of uterine overstimulation. PGE 2 can be given using a pessary inserted into the vagina, a gel or tablet; no other routes are recommended. Misoprostol is not licensed in the UK for induction of labour and is only recommended by NICE for women where the foetus has died while in the uterus (...) New evidence compares effectiveness of prostaglandin drugs for inducing labour Most effective prostaglandin drugs for inducing labour Discover Portal Discover Portal New evidence compares effectiveness of prostaglandin drugs for inducing labour Published on 7 February 2015 doi: This review partly funded by the NIHR provides the largest pooling of international data on the effectiveness of prostaglandin drugs used to induce labour. It found that the most effective prostaglandin for inducing

2018 NIHR Dissemination Centre

13. Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term. (PubMed)

Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term. Prostaglandins have been used for induction of labour since the 1960s. This is one of a series of reviews evaluating methods of induction of labour. This review focuses on prostaglandins given per vaginam, evaluating these in comparison with placebo (or expectant management) and with each other; prostaglandins (PGE2 and PGF2a); different formulations (gels, tablets, pessaries) and doses.To determine the effects of vaginal (...) prostaglandins E2 and F2a for third trimester cervical ripening or induction of labour in comparison with placebo/no treatment or other vaginal prostaglandins (except misoprostol).We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (1 March 2014) and bibliographies of relevant papers.Clinical trials comparing vaginal prostaglandins used for third trimester cervical ripening or labour induction with placebo/no treatment, with each other, or other methods listed above it on a predefined

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2014 Cochrane

14. Cost-effectiveness of term induction of labour using inpatient prostaglandin gel versus outpatient Foley catheter. (PubMed)

Cost-effectiveness of term induction of labour using inpatient prostaglandin gel versus outpatient Foley catheter. Evaluating cost-effectiveness of induction of labour (IOL) using outpatient mechanical cervical ripening using a Foley catheter (OFC) compared to inpatient chemical ripening using prostin gel (IPG).Cost-effectiveness analysis from a hospital perspective alongside a RCT. Women in a metropolitan Australian maternity hospital with an unfavourable cervix requiring IOL at term were

2015 The Australian & New Zealand journal of obstetrics & gynaecology

15. Effect of chlorella supplementation on systematic symptoms and serum levels of prostaglandins, inflammatory and oxidative markers in women with primary dysmenorrhea. (PubMed)

Effect of chlorella supplementation on systematic symptoms and serum levels of prostaglandins, inflammatory and oxidative markers in women with primary dysmenorrhea. Primary dysmenorrhea is one of the most commonly reported disorders for women that have unfavorable effects on patient's quality of life. Based on the evidences that suggest the anti-inflammatory and analgesic properties of chlorella, this double-blind, randomized, placebo controlled clinical trial aimed to evaluate the effects (...) of Chlorella supplementation on the severity of menstrual pain in a group of young women with primary dysmenorrhea.In this clinical trial, 44 girls with primary dysmenorrhea were randomly divided into intervention and control groups. Patients in the intervention group received 1500 mg/day of chlorella as 5 soft gel and the control group received placebo soft gels for eight weeks. Menstrual and food information were collected using a previously validated and published questionnaire. Anthropometric

2019 European journal of obstetrics, gynecology, and reproductive biology

16. Foley catheter versus vaginal prostaglandin E2 gel for induction of labour at term (PROBAAT trial): an open-label, randomised controlled trial. (PubMed)

Foley catheter versus vaginal prostaglandin E2 gel for induction of labour at term (PROBAAT trial): an open-label, randomised controlled trial. Induction of labour is a common obstetric procedure. Both mechanical (eg, Foley catheters) and pharmacological methods (eg, prostaglandins) are used for induction of labour in women with an unfavourable cervix. We aimed to compare the effectiveness and safety of induction of labour with a Foley catheter with induction with vaginal prostaglandin E2 (...) gel.We did an open-label, randomised controlled trial in 12 hospitals in the Netherlands between Feb 10, 2009, and May 17, 2010. We enrolled women with a term singleton pregnancy in cephalic presentation, intact membranes, an unfavourable cervix, an indication for induction of labour, and no prior caesarean section. Participants were randomly allocated by an online randomisation system to induction of labour with a 30 mL Foley catheter or vaginal prostaglandin E2 gel (1:1 ratio). Because

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2011 Lancet

17. Cost-effectiveness analysis of prostaglandin E2 gel for the induction of labour at term. (PubMed)

Cost-effectiveness analysis of prostaglandin E2 gel for the induction of labour at term. To estimate the cost-effectiveness of prostaglandin E2 (dinoprostone) vaginal gel for the induction of labour at term from the perspective of the UK's National Health Service.Economic evaluation conducted as part of a randomised controlled trial.Maternity department at a major teaching hospital in London, UK.A cohort of 165 pregnant women presenting as cephalic between 36(+⁶) and 41(+⁶) weeks of gestation (...) (bootstrap 95% CI -£1133, £3379). The results were sensitive to the inclusion of neonatal costs in the analysis and the value of the cost-effectiveness threshold. Notably, excluding neonatal costs increased the probability that the gel is cost-effective at a cost-effectiveness threshold of £100 per hour of care prevented to 0.99.This study suggests that prostaglandin E2 gel is probably more cost-effective than prostaglandin E2 tablets for the induction of labour at term. Given that the results

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2011 EvidenceUpdates

18. Prostaglandin E2 vaginal gel or tablets for the induction of labour at term: a randomised controlled trial. (PubMed)

Prostaglandin E2 vaginal gel or tablets for the induction of labour at term: a randomised controlled trial. To compare the effectiveness of prostaglandin E2 (dinopristone) vaginal gel versus vaginal tablets for the induction of labour at term.Randomised controlled clinical trial.  University maternity hospital in London.Pregnant women with cephalic presentation undergoing induction of labour after 37 weeks of gestation.Prostaglandin E2 vaginal tablets (3 mg) or vaginal gel (1 mg/ 2 mg (...) ) was administered at 6-hourly intervals until the cervix was suitable for amniotomy.Induction to delivery interval, in minutes; rate of failed induction of labour requiring caesarean delivery.Eighty-two women received prostaglandin gel; 83 women received vaginal tablets. There were significant differences between the two treatment groups in the primary outcomes. The mean induction to delivery interval was significantly shorter in women who received the gel (1400 minutes, 690-2280 minutes, versus 1780 minutes

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2011 EvidenceUpdates

19. Prostaglandins before caesarean section for preventing neonatal respiratory distress. (PubMed)

centre in Australia. The study involved 36 women (18 received intravaginal prostaglandin E 2 gel and 18 received placebo).There was one case of neonatal respiratory distress in the control group, which the trialist reported as transient tachypnoea of the newborn (risk ratio (RR) 0.33, 95% confidence interval (CI) 0.01 to 7.68, one study, n = 36).None of the neonates required mechanical ventilation and the trial authors reported median Apgar scores at one and five minutes as being similar in both (...) Prostaglandins before caesarean section for preventing neonatal respiratory distress. Respiratory distress (RD) can occur in both preterm and term neonates born through normal vaginal delivery or caesarean section (CS). It accounts for about 30% of neonatal deaths and can occur at any time following birth. Respiratory distress syndrome (RDS), transient tachypnoea (rapid breathing) of the newborn and persistent pulmonary hypertension (increased blood pressure of pulmonary vessels) of the newborn

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2013 Cochrane

20. Characterization of the Inhibitory Effects of Fevipiprant (QAW039) on Activation of Eosinophils and ILC2 Cells by Prostaglandin D2 Metabolites

Characterization of the Inhibitory Effects of Fevipiprant (QAW039) on Activation of Eosinophils and ILC2 Cells by Prostaglandin D2 Metabolites Characterization of the Inhibitory Effects of Fevipiprant (QAW039) on Activation of Eosinophils and ILC2 Cells by Prostaglandin D2 Metabolites - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Characterization of the Inhibitory Effects of Fevipiprant (QAW039) on Activation of Eosinophils and ILC2 Cells by Prostaglandin D2 Metabolites (18-03 EONOV) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2018 Clinical Trials

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