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748 results for

Prophylactic Oophorectomy

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741. Surgical risk reduction: prophylactic salpingo-oophorectomy and prophylactic mastectomy. (PubMed)

Surgical risk reduction: prophylactic salpingo-oophorectomy and prophylactic mastectomy. Investigators have used retrospective and prospective study designs to provide much needed data on the extent of risk reduction after prophylactic oophorectomy and mastectomy in women at increased risk for breast and ovarian cancer. In this publication we identify those women who may wish to consider prophylactic surgery, review data demonstrating the efficacy of prophylactic surgery, and discuss potential (...) surgical complications. We also present data about the frequency of use and psychosocial impact of prophylactic surgery in this typically young group of women. Finally, we provide general treatment guidelines for the practicing clinician.

2004 American Journal of Obstetrics and Gynecology

742. Pathologic findings in prophylactic oophorectomy specimens in high-risk women. (PubMed)

Pathologic findings in prophylactic oophorectomy specimens in high-risk women. To ascertain the frequency of significant pathologic alterations in prophylactic oophorectomy specimens in high-risk women referred to a tertiary care center.Surgical cases for prophylactic oophorectomy referred to a gynecologic oncology clinic from November 1996 to January 2001 were reviewed. Serial sections of entirely submitted tubes and ovaries were procured and reviewed by a pathologist with expertise (...) in gynecologic malignancies. All patients had undergone genetic counseling and either underwent mutational analysis of BRCA1 and BRCA2 genes or had family history suggestive for ovarian and breast cancer susceptibility.Thirty women with either a documented deleterious BRCA1 or BRCA2 mutation or a suggestive family history underwent prophylactic oophorectomy during the study period. Seventy-three percent of women had undergone genetic testing. Of those, 63.5% harbored a BRCA1 mutation, 13.5% were BRCA2

2002 Gynecologic Oncology

743. Development and preliminary evaluation of a clinical guidance programme for the decision about prophylactic oophorectomy in women undergoing a hysterectomy (PubMed)

Development and preliminary evaluation of a clinical guidance programme for the decision about prophylactic oophorectomy in women undergoing a hysterectomy To develop a decision analysis based and computerised clinical guidance programme (CGP) that provides patient specific guidance on the decision whether or not to undergo a prophylactic oophorectomy to reduce the risk of subsequent ovarian cancer and to undertake a preliminary pilot and evaluation.Women who had already agreed to have (...) a hysterectomy who otherwise had no ovarian pathology.Oophorectomy decision consultation at the outpatient or pre-admission clinic.A CGP was developed with advice from gynaecologists and patient groups, incorporating a set of Markov models within a decision analytical framework to evaluate the benefits of undergoing a prophylactic oophorectomy or not on the basis of quality adjusted life expectancy, life expectancy, and for varying durations of hormone replacement therapy. Sensitivity analysis

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2002 Quality & Safety in Health Care

744. Surveillance or surgery? A description of the factors that influence high risk premenopausal women's decisions about prophylactic oophorectomy (PubMed)

Surveillance or surgery? A description of the factors that influence high risk premenopausal women's decisions about prophylactic oophorectomy 11594337 2002 01 07 2016 11 24 1468-6244 38 10 2001 Oct Journal of medical genetics J. Med. Genet. Surveillance or surgery? A description of the factors that influence high risk premenopausal women's decisions about prophylactic oophorectomy. 683-91 Hallowell N N Jacobs I I Richards M M Mackay J J Gore M M eng Letter Research Support, Non-U.S. Gov't

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2001 Journal of Medical Genetics

745. Prophylactic oophorectomy in Northern Ireland. (PubMed)

Prophylactic oophorectomy in Northern Ireland. A postal questionnaire was sent to all gynaecological consultants and senior registrars (n = 50) in Northern Ireland to establish the prevalence of prophylactic oophorectomy. Forty three (84%) replied. 72% performed prophylactic oophorectomy (28% unilateral), 28% did not. With reference to the world literature, there appears to be no benefit from the unilateral procedure but a consensus that bilateral oophorectomy is an option which should

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1991 The Ulster medical journal

746. Prophylactic oophorectomy in operable instances of carcinoma of the breast. (PubMed)

Prophylactic oophorectomy in operable instances of carcinoma of the breast. In 1964, a prospective study was initiated of prophylactic oophorectomy in operable instances of carcinoma of the breast, in patients who showed evidence of ovarian activity. Patients were randomized to a control group and a group treated by surgical castration. By December 1979, 359 patients were evaluable at five years and 240 patients at ten years. The over-all results of the oophorectomy series were superior (...) to that for those of the control group. Patients who had cancer confined to the breast showed no significant benefit from oophorectomy. When one to three axillary nodes were involved, women less than 50 years of age were found to benefit significantly from prophylactic oophorectomy, in relapse-free status at five years, and in survival and relapse-free status at ten years. Patients 50 years of age and older showed no advantage from oophorectomy. It s suggested that there is a place for prophylactic oophorectomy

1981 Surgery, gynecology & obstetrics Controlled trial quality: uncertain

747. Prophylactic oophorectomy in the treatment of carcinoma of the breast. (PubMed)

Prophylactic oophorectomy in the treatment of carcinoma of the breast. Several prospective clinical trials have been conducted to investigate the efficacy of prophylactic ovarium ablation in the primary treatment of carcinoma of the breast. The results have varied and the follow-up periods have been rather short. A prospective randomized study was done at our institution from 1961 to 1966 to test the value of prophylactic oophorectomy in the treatment of carcinoma of the breast. The patients (...) and distribution in the different TNM stages. The results of the study did not demonstrate any significant differences in cure rate, survival time, recurrence free intervals or intervals between recurrence of the disease and death. The results were independent of nodal status, TNM classification and menstrual status of the patient. These findings do not support the use of prophylactic oophorectomy in the treatment of operable carcinoma of the breast in TNM Stages I and II, whereas no conclusion can be drawn

1986 Surgery, gynecology & obstetrics Controlled trial quality: uncertain

748. Prophylactic oophorectomy in colorectal carcinoma: preliminary results of a randomized, prospective trial. (PubMed)

Prophylactic oophorectomy in colorectal carcinoma: preliminary results of a randomized, prospective trial. Controversy exists regarding the role of prophylactic oophorectomy during resection for primary colorectal cancer.A prospective, randomized trial was initiated to evaluate the influence of oophorectomy on recurrence and survival in patients with Dukes Stages B and C colorectal cancer.Between November 1986 and March 1997, 155 patients were randomized to oophorectomy or no oophorectomy (...) at laparotomy for resection of colorectal cancer.No incidence of gross or microscopic metastatic disease to the ovary was found among 77 patients randomized to oophorectomy, in contrast to previous reports. Preliminary crude survival curves suggested a survival benefit for oophorectomy between two and three years from surgery, but Kaplan-Meier survival analysis indicated that this was not statistically significant and the benefit does not appear to persist at five years. Kaplan-Meier curves of recurrence

1998 Diseases of the colon and rectum Controlled trial quality: uncertain

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