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Prophylactic Oophorectomy

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21. Inappropriate oophorectomy at time of benign premenopausal hysterectomy. (Abstract)

Inappropriate oophorectomy at time of benign premenopausal hysterectomy. We assessed rates of oophorectomy during benign hysterectomy around the release of the American College of Obstetricians and Gynecologists 2008 practice bulletin on prophylactic oophorectomy, and evaluated predictors of inappropriate premenopausal oophorectomy.A cross-sectional administrative database analysis was performed utilizing the California Office of Statewide Health Planning Development Patient Discharge Database (...) for years 2005 to 2011. After identifying all premenopausal women undergoing hysterectomy for benign conditions, International Classification of Diseases (ICD)-9 diagnosis codes were reviewed to create a master list of indications for oophorectomy. We defined appropriate oophorectomy as cases with concomitant coding for ovarian cyst, breast cancer susceptibility gene carrier status, and other diagnoses. Using patient demographics and hospital characteristics to predict inappropriate oophorectomy

2017 Menopause

22. Prophylactic bilateral oophorectomy at time of hysterectomy for women at low risk: acog revises practice guidelines for ovarian cancer screening in low-risk women (Full text)

Prophylactic bilateral oophorectomy at time of hysterectomy for women at low risk: acog revises practice guidelines for ovarian cancer screening in low-risk women 24523599 2014 02 13 2018 11 13 1198-0052 21 1 2014 Feb Current oncology (Toronto, Ont.) Curr Oncol Prophylactic bilateral oophorectomy at time of hysterectomy for women at low risk: acog revises practice guidelines for ovarian cancer screening in low-risk women. 9-12 10.3747/co.21.1721 Larson C A CA University of Kentucky, Lexington

2014 Current Oncology PubMed abstract

23. Acceptability of prophylactic salpingectomy with delayed oophorectomy as risk-reducing surgery among BRCA mutation carriers. (Full text)

conducted by Facing Our Risk of Cancer Empowered (FORCE), a patient advocacy group, from October 2010 to August 2012. Premenopausal BRCA mutation carriers with no history of ovarian cancer or prior bilateral salpingo-oophorectomy (BSO) were included.Of the 204 women meeting inclusion criteria, median age was 35 years, 92.5% were white, 25.7% were Jewish, and 16.7% had a history of breast cancer. Overall, 34.3% reported interest in a study of salpingectomy, 35.3% were unsure, and 30.4% were (...) Acceptability of prophylactic salpingectomy with delayed oophorectomy as risk-reducing surgery among BRCA mutation carriers. Given the emerging evidence for the fimbria as the site of origin for many serous carcinomas in BRCA mutation carriers, consideration is being given in studying prophylactic salpingectomy with delayed oophorectomy (PSDO) as a risk-reducing surgery. We aimed to determine the interest in a study of PSDO among these women.We evaluated the results of an online survey

2014 Gynecologic Oncology PubMed abstract

24. Prophylactic Salpingectomy With Delayed Oophorectomy

Prophylactic Salpingectomy With Delayed Oophorectomy Prophylactic Salpingectomy With Delayed Oophorectomy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prophylactic Salpingectomy With Delayed Oophorectomy (...) Description Go to Brief Summary: The goal of this clinical research study is to compare ovarian cancer screening, risk-reducing salpingo-oophorectomy (RRSO), and prophylactic salpingectomy with delayed oophorectomy (PSDO). The safety of RRSO and PSDO will also be studied. Ovarian cancer screening does not involve a surgical procedure. Instead, physical exams, blood tests, and ultrasound are used to check for ovarian, fallopian tube, and peritoneal cancer. The surgical procedures, RRSO and PSDO

2013 Clinical Trials

25. Histologic evaluation of prophylactic hysterectomy and oophorectomy in Lynch syndrome. (Full text)

Histologic evaluation of prophylactic hysterectomy and oophorectomy in Lynch syndrome. Women with Lynch syndrome (LS) are at increased risk for endometrial (EC) and ovarian carcinoma (OC). Current surveillance recommendations for detection of EC and OC in LS patients are not effective. Small studies have shown that prophylactic hysterectomy and bilateral salpingo-oophorectomy (P-TH-BSO) are the most effective and least expensive preventive measures in these patients. Data regarding histologic (...) findings in prophylactic specimens in these patients are lacking. All LS patients who underwent P-TH-BSO at the Memorial Sloan-Kettering Cancer Center from 2000 to 2011 were identified. Slides were evaluated for the presence of endometrial hyperplasia (EH), EC, OC, or any other recurrent histologic findings. Twenty-five patients were identified, with an age range of 36 to 61 years. Fifteen patients had a synchronous or prior colorectal carcinoma, and 2 patients had a history of sebaceous carcinoma

2013 American Journal of Surgical Pathology PubMed abstract

26. High-Grade Serous Tumor Arising from Fallopian Tube in a BRCA Mutation Carrier after Prophylactic Oophorectomy (Full text)

High-Grade Serous Tumor Arising from Fallopian Tube in a BRCA Mutation Carrier after Prophylactic Oophorectomy We present the case of a 67-year-old patient with a BRCA1 mutation and breast cancer who underwent prophylactic oophorectomy. After 6 years, an abdominal computed tomography revealed a pelvic mass which proved to be a poorly differentiated serous carcinoma originating from the right residual tube which previously had not been removed during prophylactic surgery. This case report (...) suggests that much effort should be made during prophylactic oophorectomy to completely remove the tubes, especially in light of the recent pathologic theories on the tubal origin of ovarian cancer.

2013 Case reports in oncology PubMed abstract

27. The Impact of an Expanded Genetic Testing Program and Selective Oophorectomy on the Incidence of Ovarian Cancer in West Pomerania. (Abstract)

of 641 women were found to carry a mutation (1.7%) and of these, 220 had a prophylactic oophorectomy (34.3%). A total of 12 women had an occult cancer diagnosed at the time of prophylactic oophorectomy (5.5%). We estimate that 26 more ovarian cancers would have been diagnosed by January 2015 in the absence of these oophorectomies and that an additional 25 cancers will be prevented in the future (total 51). During this period, 1611 ovarian cancers were diagnosed in the region; therefore we estimate (...) that approximately 1.6% of ovarian cancers were prevented between 1999 and 2015 by our genetic testing program. We conclude that the prophylactic oophorectomies performed between 1999 and 2010 as a result of widespread BRCA1 mutation testing have reduced the incidence of ovarian cancer in Pomerania by a small amount (about 1.6%), and that the impact of genetic testing will increase in the coming years.© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2016 Clinical Genetics

28. Commercially available lifestyle modification program: randomized controlled trial addressing heart and bone health in BRCA1/2+ breast cancer survivors after risk-reducing salpingo-oophorectomy. (Full text)

Commercially available lifestyle modification program: randomized controlled trial addressing heart and bone health in BRCA1/2+ breast cancer survivors after risk-reducing salpingo-oophorectomy. The goal of this RCT was to examine the efficacy and safety of a web-based program to improve cardiovascular and bone health outcomes, among 35 BRCA1/2+ breast cancer survivors who underwent prophylactic oophorectomy and thus experienced premature surgical menopause.A 12-month commercially available web

2016 Journal of cancer survivorship : research and practice Controlled trial quality: uncertain PubMed abstract

29. Prophylactic Oophorectomy

Prophylactic Oophorectomy Prophylactic Oophorectomy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Prophylactic Oophorectomy (...) Prophylactic Oophorectomy Aka: Prophylactic Oophorectomy II. Indications: High Risk for Ovarian Cancer Hereditary Syndromes ( , , Lynch II) III. Protocol Oophorectomy at age 35 or when childbearing complete after oophorectomy IV. Efficacy Reduces risk Peritoneal Primary papillary serous tumors may occur V. Adverse Effects Premenopausal oophorectomy increases risk of cognitive decline Higher risk with younger age at oophorectomy Risk is countered if is continued to age 50 years Images: Related links

2015 FP Notebook

30. Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice. (Full text)

Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice. Periodontal pathogens and/or inflammatory products from periodontitis participate in the development or progression of systemic diseases. In this context, periodontitis acts as a modifying factor to systemic health, including diabetes and cardiovascular diseases. Osteoporosis is an increasingly prevalent condition in our aging population and considered a risk factor for periodontal disease, but the effect (...) that EP and ovariectomy (OVX) induced a significantly higher femoral and mandibular bone loss compared to EP or OVX alone. EP alone did not induce systemic bone loss. In addition, the EP+OVX and EP groups showed significantly higher levels of tumor necrosis factor (TNF)-α than OVX and control groups at end point. These results suggest that periodontitis could be a risk factor for systemic bone loss, especially in post-menopausal women, and warrant further clinical investigations to confirm

2015 Bone PubMed abstract

31. Determinants of the decision to perform prophylactic oophorectomy in association with a hysterectomy for a benign condition. (Abstract)

Determinants of the decision to perform prophylactic oophorectomy in association with a hysterectomy for a benign condition. The decision to perform an elective bilateral salpingo-oophorectomy (BSO) at the time of a hysterectomy for a benign condition is complex.To assess the determinants of the decision to proceed to a prophylactic BSO during a hysterectomy for a benign condition.We collected demographic and clinical data, including age, menopausal status and risk of ovarian cancer. Using (...) a regression model we analysed the decision perform a prophylactic BSO in women successively admitted for a hysterectomy for a benign condition, in relation to the collected demographic and clinical data.Data were collected for 43 women, aged between 37 and 65 years (mean age 48.6 years, SD 6.9), on the day before their hysterectomy. Thirty-six (84%) had a total hysterectomy and 7 (16%) a subtotal hysterectomy; 40 (93%) had a laparoscopic procedure. Prophylactic BSO was significantly associated with age

2012 Maturitas

32. Prophylactic Salpingectomy and Delayed Oophorectomy as an Alternative for BRCA Mutation Carriers. (Abstract)

Prophylactic Salpingectomy and Delayed Oophorectomy as an Alternative for BRCA Mutation Carriers. Prophylactic bilateral salpingo-oophorectomy is advised for women with BRCA mutations, but there are adverse consequences of premature menopause. The majority of BRCA-associated ovarian cancers appear to arise in the fallopian tube; therefore, salpingectomy may be an alternative to bilateral salpingo-oophorectomy. We compared the costs and benefits of salpingectomy with bilateral salpingo (...) -oophorectomy among BRCA mutation carriers.We developed a Markov Monte Carlo simulation model to compare three strategies for risk reduction in women with BRCA mutations: 1) bilateral salpingo-oophorectomy; 2) bilateral salpingectomy; and 3) bilateral salpingectomy with delayed oophorectomy. Net health benefits were measured in years-of-life expectancy and quality-adjusted life-year expectancy, and the primary outcome was the incremental cost-effectiveness ratio. The model estimated the number of future

2012 Obstetrics and Gynecology

33. Prophylactic oophorectomy rates in relation to a guideline update on referral to genetic counseling. (Full text)

Prophylactic oophorectomy rates in relation to a guideline update on referral to genetic counseling. We sought to determine whether prophylactic oophorectomy rates changed after the introduction of a 2007 health plan clinical guideline recommending systematic referral to a genetic counselor for women with a personal or family history suggestive of an inherited susceptibility to breast/ovarian cancer.We conducted a retrospective cohort study of female members of Group Health, an integrated (...) delivery system in Washington State. Subjects were women aged ≥ 35 years during 2004-2009 who reported a personal or family history consistent with an inherited susceptibility to breast/ovarian cancer. Personal and family history information was collected on a questionnaire completed when the women had a mammogram. We ascertained oophorectomies from automated claims data and determined whether surgeries were prophylactic by medical chart review. Rates were age-adjusted and age-adjusted incidence rate

2012 Gynecologic Oncology PubMed abstract

34. Sexual activity and functioning after risk-reducing salpingo-oophorectomy: impact of hormone replacement therapy. (Abstract)

Sexual activity and functioning after risk-reducing salpingo-oophorectomy: impact of hormone replacement therapy. To examine sexual activity and functioning in women after risk-reducing salpingo-oophorectomy (RRSO) compared with the general population (NORM).Retrospective cohort study. 294 women who underwent RRSO and 1228 women from the NORM group provided written information based on mailed questionnaires. Sexual pleasure and discomfort scores and frequency of sexual activity were evaluated (...) . In the RRSO group, systemic HRT users reported less discomfort than did the nonusers. Health care providers should be attentive to these issues when counseling before and after prophylactic surgery.Copyright © 2015 Elsevier Inc. All rights reserved.

2015 Gynecologic Oncology

35. A Model for Estimating Ovarian Cancer Risk: Application for Preventive Oophorectomy. (Abstract)

A Model for Estimating Ovarian Cancer Risk: Application for Preventive Oophorectomy. It is important to identify women in the population who have a high risk of ovarian cancer and who might benefit from prophylactic bilateral salpingo-oophorectomy. The probability that a woman will develop ovarian cancer depends on her current age, her reproductive history and her genetic status.We simulated the distribution of ovarian cancer risk for the 2011 Ontario female population. We generated (at random

2015 Gynecologic Oncology

36. Twenty Years' Experience with Prophylactic Bilateral Oophorectomy in the Treatment of Carcinoma of the Breast (Full text)

Twenty Years' Experience with Prophylactic Bilateral Oophorectomy in the Treatment of Carcinoma of the Breast 14449032 1998 11 01 2018 12 01 0003-4932 155 1962 Jun Annals of surgery Ann. Surg. Twenty years' experience with prophylactic bilateral oophorectomy in the treatment of carcinoma of the breast. 935-9 HORSLEY J S JS 3rd HORSLEY G W GW eng Journal Article United States Ann Surg 0372354 0003-4932 OM Breast Breast Neoplasms therapy Carcinoma Castration Female Humans Ovariectomy BREAST

1962 Annals of Surgery PubMed abstract

37. Early (Prophylactic) Oophorectomy and Adrenalectomy in Carcinoma of the Breast; An Interim Report (Full text)

Early (Prophylactic) Oophorectomy and Adrenalectomy in Carcinoma of the Breast; An Interim Report 13733304 1998 11 01 2018 11 30 0007-0920 14 1960 Sep British journal of cancer Br. J. Cancer Early (prophylactic) oophorectomy and adrenalectomy in carcinoma of the breast; an interim report. 457-9 PATEY D H DH eng Journal Article England Br J Cancer 0370635 0007-0920 OM Adrenalectomy Breast Breast Neoplasms surgery Carcinoma Castration Female Humans Mastectomy Ovariectomy ADRENALECTOMY BREAST

1960 British journal of cancer PubMed abstract

38. Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine. (Abstract)

bursts in hippocampal CA3. All three compounds reduced N-methyl-D-aspartate receptor (NMDAR)-mediated currents 1 week after administration. Furthermore, ovarian-derived hormones were necessary for and sufficient to restore (R,S)-ketamine- and (2R,6R)-HNK-mediated prophylaxis in female mice. Our data provide further evidence that resilience-enhancing prophylactics may alter AMPAR-mediated glutamatergic transmission in CA3. Moreover, we show that prophylactics against stress-induced depressive-like (...) Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine. Enhancing stress resilience in at-risk populations could significantly reduce the incidence of stress-related psychiatric disorders. We have previously reported that the administration of (R,S)-ketamine prevents stress-induced depressive-like behavior in male mice, perhaps by altering α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated

2020 Neuropsychopharmacology

39. Early Salpingectomy (Tubectomy) With Delayed Oophorectomy in BRCA1/2 Gene Mutation Carriers

salpingo-oophorectomy at current guideline ages (age 35-40 for BRCA1 mutation carriers and age 40-45 for BRCA2 mutation carriers). Procedure: Risk-reducing salpingo-oophorectomy This is the current guideline procedure, usually performed between age 35 and 40 in BRCA1 mutation carriers and between age 40 and 45 in BRCA2 mutation carriers. Other Name: Bilateral prophylactic salpingo-oophorectomy Outcome Measures Go to Primary Outcome Measures : Menopause-related quality of life [ Time Frame: Up to 5 (...) : Postmenopausal status (natural menopause or due to (cancer) treatment) Wish for second stage oophorectomy within two years after salpingectomy (if clear at enrollment) Legally incapable Prior bilateral salpingectomy A personal history of ovarian, fallopian tube or peritoneal cancer Evidence of malignant disease at enrollment Treatment for malignant disease at enrollment Inability to read or speak Dutch BRCA mutation carriers who opt for salpingectomy but who do not want to postpone the oophorectomy beyond

2014 Clinical Trials

40. Impact of Oophorectomy on Cancer Incidence and Mortality in Women With a BRCA1 or BRCA2 Mutation. (Full text)

Impact of Oophorectomy on Cancer Incidence and Mortality in Women With a BRCA1 or BRCA2 Mutation. The purposes of this study were to estimate the reduction in risk of ovarian, fallopian tube, or peritoneal cancer in women with a BRCA1 or BRCA2 mutation after oophorectomy, by age of oophorectomy; to estimate the impact of prophylactic oophorectomy on all-cause mortality; and to estimate 5-year survival associated with clinically detected ovarian, occult, and peritoneal cancers diagnosed (...) women developed either ovarian (n = 132), fallopian (n = 22), or peritoneal (n = 32) cancer, of whom 68 have died. HR for ovarian, fallopian, or peritoneal cancer associated with bilateral oophorectomy was 0.20 (95% CI, 0.13 to 0.30; P < .001). Among women who had no history of cancer at baseline, HR for all-cause mortality to age 70 years associated with an oophorectomy was 0.23 (95% CI, 0.13 to 0.39; P < .001).Preventive oophorectomy was associated with an 80% reduction in the risk of ovarian

2014 Journal of Clinical Oncology PubMed abstract

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