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Prophylactic Oophorectomy

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21. The Impact of an Expanded Genetic Testing Program and Selective Oophorectomy on the Incidence of Ovarian Cancer in West Pomerania. (PubMed)

of 641 women were found to carry a mutation (1.7%) and of these, 220 had a prophylactic oophorectomy (34.3%). A total of 12 women had an occult cancer diagnosed at the time of prophylactic oophorectomy (5.5%). We estimate that 26 more ovarian cancers would have been diagnosed by January 2015 in the absence of these oophorectomies and that an additional 25 cancers will be prevented in the future (total 51). During this period, 1611 ovarian cancers were diagnosed in the region; therefore we estimate (...) that approximately 1.6% of ovarian cancers were prevented between 1999 and 2015 by our genetic testing program. We conclude that the prophylactic oophorectomies performed between 1999 and 2010 as a result of widespread BRCA1 mutation testing have reduced the incidence of ovarian cancer in Pomerania by a small amount (about 1.6%), and that the impact of genetic testing will increase in the coming years.© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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2016 Clinical Genetics

22. Commercially available lifestyle modification program: randomized controlled trial addressing heart and bone health in BRCA1/2+ breast cancer survivors after risk-reducing salpingo-oophorectomy. (PubMed)

Commercially available lifestyle modification program: randomized controlled trial addressing heart and bone health in BRCA1/2+ breast cancer survivors after risk-reducing salpingo-oophorectomy. The goal of this RCT was to examine the efficacy and safety of a web-based program to improve cardiovascular and bone health outcomes, among 35 BRCA1/2+ breast cancer survivors who underwent prophylactic oophorectomy and thus experienced premature surgical menopause.A 12-month commercially available web

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2016 Journal of cancer survivorship : research and practice Controlled trial quality: uncertain

23. Histologic evaluation of prophylactic hysterectomy and oophorectomy in Lynch syndrome. (PubMed)

Histologic evaluation of prophylactic hysterectomy and oophorectomy in Lynch syndrome. Women with Lynch syndrome (LS) are at increased risk for endometrial (EC) and ovarian carcinoma (OC). Current surveillance recommendations for detection of EC and OC in LS patients are not effective. Small studies have shown that prophylactic hysterectomy and bilateral salpingo-oophorectomy (P-TH-BSO) are the most effective and least expensive preventive measures in these patients. Data regarding histologic (...) findings in prophylactic specimens in these patients are lacking. All LS patients who underwent P-TH-BSO at the Memorial Sloan-Kettering Cancer Center from 2000 to 2011 were identified. Slides were evaluated for the presence of endometrial hyperplasia (EH), EC, OC, or any other recurrent histologic findings. Twenty-five patients were identified, with an age range of 36 to 61 years. Fifteen patients had a synchronous or prior colorectal carcinoma, and 2 patients had a history of sebaceous carcinoma

2013 American Journal of Surgical Pathology

24. Prophylactic Salpingectomy With Delayed Oophorectomy

Prophylactic Salpingectomy With Delayed Oophorectomy Prophylactic Salpingectomy With Delayed Oophorectomy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prophylactic Salpingectomy With Delayed Oophorectomy (...) Description Go to Brief Summary: The goal of this clinical research study is to compare ovarian cancer screening, risk-reducing salpingo-oophorectomy (RRSO), and prophylactic salpingectomy with delayed oophorectomy (PSDO). The safety of RRSO and PSDO will also be studied. Ovarian cancer screening does not involve a surgical procedure. Instead, physical exams, blood tests, and ultrasound are used to check for ovarian, fallopian tube, and peritoneal cancer. The surgical procedures, RRSO and PSDO

2013 Clinical Trials

25. High-Grade Serous Tumor Arising from Fallopian Tube in a BRCA Mutation Carrier after Prophylactic Oophorectomy (PubMed)

High-Grade Serous Tumor Arising from Fallopian Tube in a BRCA Mutation Carrier after Prophylactic Oophorectomy We present the case of a 67-year-old patient with a BRCA1 mutation and breast cancer who underwent prophylactic oophorectomy. After 6 years, an abdominal computed tomography revealed a pelvic mass which proved to be a poorly differentiated serous carcinoma originating from the right residual tube which previously had not been removed during prophylactic surgery. This case report (...) suggests that much effort should be made during prophylactic oophorectomy to completely remove the tubes, especially in light of the recent pathologic theories on the tubal origin of ovarian cancer.

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2013 Case reports in oncology

26. Prophylactic Salpingectomy and Delayed Oophorectomy as an Alternative for BRCA Mutation Carriers. (PubMed)

Prophylactic Salpingectomy and Delayed Oophorectomy as an Alternative for BRCA Mutation Carriers. Prophylactic bilateral salpingo-oophorectomy is advised for women with BRCA mutations, but there are adverse consequences of premature menopause. The majority of BRCA-associated ovarian cancers appear to arise in the fallopian tube; therefore, salpingectomy may be an alternative to bilateral salpingo-oophorectomy. We compared the costs and benefits of salpingectomy with bilateral salpingo (...) -oophorectomy among BRCA mutation carriers.We developed a Markov Monte Carlo simulation model to compare three strategies for risk reduction in women with BRCA mutations: 1) bilateral salpingo-oophorectomy; 2) bilateral salpingectomy; and 3) bilateral salpingectomy with delayed oophorectomy. Net health benefits were measured in years-of-life expectancy and quality-adjusted life-year expectancy, and the primary outcome was the incremental cost-effectiveness ratio. The model estimated the number of future

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2012 Obstetrics and Gynecology

27. Determinants of the decision to perform prophylactic oophorectomy in association with a hysterectomy for a benign condition. (PubMed)

Determinants of the decision to perform prophylactic oophorectomy in association with a hysterectomy for a benign condition. The decision to perform an elective bilateral salpingo-oophorectomy (BSO) at the time of a hysterectomy for a benign condition is complex.To assess the determinants of the decision to proceed to a prophylactic BSO during a hysterectomy for a benign condition.We collected demographic and clinical data, including age, menopausal status and risk of ovarian cancer. Using (...) a regression model we analysed the decision perform a prophylactic BSO in women successively admitted for a hysterectomy for a benign condition, in relation to the collected demographic and clinical data.Data were collected for 43 women, aged between 37 and 65 years (mean age 48.6 years, SD 6.9), on the day before their hysterectomy. Thirty-six (84%) had a total hysterectomy and 7 (16%) a subtotal hysterectomy; 40 (93%) had a laparoscopic procedure. Prophylactic BSO was significantly associated with age

2012 Maturitas

28. Prophylactic Oophorectomy

Prophylactic Oophorectomy Prophylactic Oophorectomy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Prophylactic Oophorectomy (...) Prophylactic Oophorectomy Aka: Prophylactic Oophorectomy II. Indications: High Risk for Ovarian Cancer Hereditary Syndromes ( , , Lynch II) III. Protocol Oophorectomy at age 35 or when childbearing complete after oophorectomy IV. Efficacy Reduces risk Peritoneal Primary papillary serous tumors may occur V. Adverse Effects Premenopausal oophorectomy increases risk of cognitive decline Higher risk with younger age at oophorectomy Risk is countered if is continued to age 50 years Images: Related links

2015 FP Notebook

29. Prophylactic oophorectomy rates in relation to a guideline update on referral to genetic counseling. (PubMed)

Prophylactic oophorectomy rates in relation to a guideline update on referral to genetic counseling. We sought to determine whether prophylactic oophorectomy rates changed after the introduction of a 2007 health plan clinical guideline recommending systematic referral to a genetic counselor for women with a personal or family history suggestive of an inherited susceptibility to breast/ovarian cancer.We conducted a retrospective cohort study of female members of Group Health, an integrated (...) delivery system in Washington State. Subjects were women aged ≥ 35 years during 2004-2009 who reported a personal or family history consistent with an inherited susceptibility to breast/ovarian cancer. Personal and family history information was collected on a questionnaire completed when the women had a mammogram. We ascertained oophorectomies from automated claims data and determined whether surgeries were prophylactic by medical chart review. Rates were age-adjusted and age-adjusted incidence rate

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2012 Gynecologic Oncology

30. Comparing surgical outcome and ovarian reserve after laparoscopic hysterectomy between two methods of with and without prophylactic bilateral salpingectomy: A randomized controlled trial. (PubMed)

Comparing surgical outcome and ovarian reserve after laparoscopic hysterectomy between two methods of with and without prophylactic bilateral salpingectomy: A randomized controlled trial. This study aimed to compare the surgical outcome and ovarian reserve in premenopausal women undergoing laparoscopic hysterectomy (without oophorectomy) for benign cause between two methods of with and without prophylactic bilateral salpingectomy.In a prospective randomized clinical trial, 62 premenopausal (...) , in both groups, postoperative AMH levels were significantly lower and FSH levels were significantly higher than before surgery.Prophylactic bilateral salpingectomy at the time of laparoscopic hysterectomy neither has a negative effect on ovarian reserve nor increases the surgical risk. Therefore, we may recommend gynecologic surgeons to perform prophylactic bilateral salpingectomy during laparoscopic hysterectomy to conserve both ovaries.

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2018 Journal of cancer research and therapeutics Controlled trial quality: uncertain

31. A cost-effectiveness analysis of prophylactic surgery versus gynecologic surveillance for women from hereditary non-polyposis colorectal cancer (HNPCC) families

syndrome or hereditary non-polyposis colorectal cancer. Interventions The interventions were annual gynaecologic examinations, over a lifetime; annual surveillance, including transvaginal ultrasound, endometrial biopsy, and blood serum CA-125 testing; and prophylactic hysterectomy and bilateral salpingo-oophorectomy at age 30 years. Location/setting USA/in-patient secondary care. Methods Analytical approach: A decision tree combined published literature to compare the costs and outcomes of the three (...) health states were from published studies. Measure of benefit: The measure of benefit was quality-adjusted life-years (QALYs). Future benefits were discounted at an annual rate of 3%. Cost data: The direct costs were those of gynaecological examinations; screening tests; prophylactic abdominal hysterectomy and salpingo-oophorectomy; chemotherapy; radiation for endometrial cancer; pathology evaluations; and cancer care. The costs of cancer care were from a study published in 1987, using 1984 prices

2012 NHS Economic Evaluation Database.

32. The impact of prophylactic salpingo-oophorectomy on menopausal symptoms and sexual function in women who carry a BRCA mutation. (PubMed)

The impact of prophylactic salpingo-oophorectomy on menopausal symptoms and sexual function in women who carry a BRCA mutation. Prophylactic salpingo-oophorectomy is recommended to women who carry a BRCA1 or BRCA2 mutation to reduce the risks of breast, ovarian and fallopian tube cancer. We measured the impact of prophylactic salpingo-oophorectomy on menopausal symptoms and sexual functioning in women with a BRCA mutation.Women who underwent prophylactic salpingo-oophorectomy between October 1 (...) , 2002 and June 26, 2008 for a known BRCA1 or BRCA2 mutation were invited to participate. Participants completed questionnaires before prophylactic surgery and again one year after surgery. Measures of sexual functioning and menopausal symptoms before and after surgery were compared. Satisfaction with the decision to undergo prophylactic salpingo-oophorectomy was evaluated.114 women who underwent prophylactic surgery completed questionnaires before and one year after surgery. Subjects who were

2011 Gynecologic Oncology

33. Quality of life and health status after prophylactic salpingo-oophorectomy in women who carry a BRCA mutation: A review. (PubMed)

Quality of life and health status after prophylactic salpingo-oophorectomy in women who carry a BRCA mutation: A review. Prophylactic salpingo-oophorectomy is recommended to women who carry a BRCA1 or BRCA2 mutation at age 35 or after childbearing is complete. This procedure is the mainstay of ovarian and fallopian tube cancer prevention in these women. Therefore an understanding of the short and long-term impact of the surgery is essential. Salpingo-oophorectomy, particularly when done prior (...) and after surgery, however vasomotor symptoms related to surgical menopause and changes in sexual functioning are common. HRT appears to mitigate some but not all of these symptoms. Women report high levels of satisfaction with their decision to have the surgery despite the impact of prophylactic salpingo-oophorectomy. Studies of the long term health and quality of life after salpingo-oophorectomy in women who carry a BRCA mutation have not yet been published.Copyright © 2011 Elsevier Ireland Ltd. All

2011 Maturitas

34. Evidence-based medicine: an analysis of prophylactic bilateral oophorectomy at time of hysterectomy for benign conditions (PubMed)

Evidence-based medicine: an analysis of prophylactic bilateral oophorectomy at time of hysterectomy for benign conditions 21331276 2011 07 14 2018 11 13 1718-7729 18 1 2011 Jan Current oncology (Toronto, Ont.) Curr Oncol Evidence-based medicine: an analysis of prophylactic bilateral oophorectomy at time of hysterectomy for benign conditions. 13-5 Larson C A CA University of Kentucky, Lexington, KY, U.S.A. eng Journal Article Canada Curr Oncol 9502503 1198-0052 Prophylactic bilateral (...) oophorectomy hysterectomy incidental bilateral oophorectomy noncancerous uterine fibroids 2011 2 19 6 0 2011 2 19 6 0 2011 2 19 6 1 ppublish 21331276 PMC3031351 J Med Ethics. 2002 Feb;28(1):10-6 11834752 Calif Med. 1958 Jul;89(1):30-2 13561114 Obstet Gynecol. 2005 Aug;106(2):219-26 16055568 Lancet Oncol. 2006 Oct;7(10):821-8 17012044 Neurology. 2008 Jan 15;70(3):200-9 17761549 BMJ. 1996 Jan 13;312(7023):71-2 8555924 Neurodegener Dis. 2008;5(3-4):257-60 18322406 Menopause Int. 2008 Sep;14(3):111-6 18714076

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2011 Current Oncology

35. Effect of prophylactic dexamethasone on nausea and vomiting after laparoscopic gynecological operation: meta-analysis

Effect of prophylactic dexamethasone on nausea and vomiting after laparoscopic gynecological operation: meta-analysis Effect of prophylactic dexamethasone on nausea and vomiting after laparoscopic gynecological operation: meta-analysis Effect of prophylactic dexamethasone on nausea and vomiting after laparoscopic gynecological operation: meta-analysis Wang B, He KH, Jiang MB, Liu C, Min S CRD summary This review found that prophylactic administration of dexamethasone was associated with less (...) postoperative nausea and vomiting in patients who underwent laparoscopic gynaecological surgery. Potential for some biases and a lack of information on study quality make the reliability of the authors' conclusions unclear. Authors' objectives To evaluate the effect of prophylactic administration of dexamethasone on post-surgical nausea and vomiting in patients who underwent laparoscopic gynaecological surgery. Searching PubMed, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials

2011 DARE.

36. Feasibility of Prophylactic Salpingectomy During Vaginal Hysterectomy. (PubMed)

Feasibility of Prophylactic Salpingectomy During Vaginal Hysterectomy. The American Congress of Obstetricians and Gynecologists recommends that "the surgeon and patient discuss the potential benefits of the removal of the fallopian tubes during a hysterectomy in women at population risk of ovarian cancer who are not having an oophorectomy," resulting in an increasing rate of salpingectomy at the time of hysterectomy. Rates of salpingectomy are highest for laparoscopic and lowest for vaginal

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2017 American Journal of Obstetrics and Gynecology

37. Differences Among a Modern Cohort of BRCA Mutation Carriers Choosing Bilateral Prophylactic Mastectomies Compared to Breast Surveillance. (PubMed)

cancer (10 vs. 20%, p = 0.01). Furthermore, women undergoing BPM were more likely to be married (78 vs. 62%, p = 0.01), to have more children (median 2 vs. 1, p < 0.001), and to have undergone a prophylactic oophorectomy (61 vs. 37%, p < 0.001). Women choosing BPM had more first-degree relatives (63 vs. 48%, p = 0.01) or a sister (23 vs. 14%, p = 0.02) with a history of breast cancer and were more likely to have a family member with ovarian cancer under the age of 40 years (9 vs. 4%, p = 0.03 (...) Differences Among a Modern Cohort of BRCA Mutation Carriers Choosing Bilateral Prophylactic Mastectomies Compared to Breast Surveillance. Women with a BRCA mutation have significantly elevated breast cancer risk, which can be reduced by >90% with bilateral prophylactic mastectomy (BPM). We sought to compare a cohort of BRCA mutation carriers choosing BPM versus breast surveillance to better elucidate factors that may impact decision making.Women with a BRCA mutation were retrospectively

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2017 Annals of Surgical Oncology

38. Prophylactic Surgery: For Whom, When and How? (PubMed)

Prophylactic Surgery: For Whom, When and How? Risk-reducing surgery has proved to be a reasonable procedure in healthy women with a definitely elevated risk of developing cancer. Here we consider the elevated risk of breast and ovarian cancer. There is a clear indication for such surgery in healthy women with a pathogenic BRCA1/2 mutation. For these patients, a risk-reducing bilateral mastectomy leads to a verifiable reduction in mortality from breast cancer, particularly for young patients (...) and a better prognosis of the primary disease make a contralateral mastectomy (CPM) more reasonable. In the case of BRCA mutation-related cancer, a reduction of mortality through CPM has been proven. A risk-reducing adnexectomy is basically recommended for BRCA mutation carriers. Healthy premenopausal women need a subsequent hormone replacement therapy. The prognosis of the patients is dominated by the ovarian carcinoma. This can be prevented by risk-reducing salpingo-oophorectomy in 95% of the cases.

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2017 Breast Care

39. Early (Prophylactic) Oophorectomy and Adrenalectomy in Carcinoma of the Breast; An Interim Report (PubMed)

Early (Prophylactic) Oophorectomy and Adrenalectomy in Carcinoma of the Breast; An Interim Report 13733304 1998 11 01 2018 11 30 0007-0920 14 1960 Sep British journal of cancer Br. J. Cancer Early (prophylactic) oophorectomy and adrenalectomy in carcinoma of the breast; an interim report. 457-9 PATEY D H DH eng Journal Article England Br J Cancer 0370635 0007-0920 OM Adrenalectomy Breast Breast Neoplasms surgery Carcinoma Castration Female Humans Mastectomy Ovariectomy ADRENALECTOMY BREAST

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1960 British journal of cancer

40. Twenty Years' Experience with Prophylactic Bilateral Oophorectomy in the Treatment of Carcinoma of the Breast (PubMed)

Twenty Years' Experience with Prophylactic Bilateral Oophorectomy in the Treatment of Carcinoma of the Breast 14449032 1998 11 01 2018 12 01 0003-4932 155 1962 Jun Annals of surgery Ann. Surg. Twenty years' experience with prophylactic bilateral oophorectomy in the treatment of carcinoma of the breast. 935-9 HORSLEY J S JS 3rd HORSLEY G W GW eng Journal Article United States Ann Surg 0372354 0003-4932 OM Breast Breast Neoplasms therapy Carcinoma Castration Female Humans Ovariectomy BREAST

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1962 Annals of Surgery

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