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161. Methadone Safety

Interactions D rug E ffects on M ethadone L evels ∗ E ffects on QT c I nterval A dditive S edative or R espiratory D epressant E ffects Antibiotics Ciprofloxacin ↑ Clarithromycin ↑ ↑ Erythromycin ↑ ↑ Itraconazole ↑ Ketoconazole ↑ Fluconazole ↑ Rifampin ↓ Telithromycin ↑ Anticonvulsants Carbamazepine ↓ Phenytoin ↓ Antihistamines Diphenhydramine ↑ Promethazine ↑ Antipsychotics Quetiapine ↑ ↑ Barbiturates Phenobarbital ↓ ↑ Benzodiazepines Alprazolam ↑ ↑ Clorazepate ↑ ↑ Diazepam ↑ ↑ Estazolam ↑ ↑ Flurazepam

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2014 Publication 1228

163. Extravasation and infiltration

Calcium gluconate 10% Potassium chloride 7.45% Sodium bicarbonate 4.2% & 8.4% Sodium chloride 10% Cytotoxic agents Busulphan Actinomycin-D Daunorubicin Doxorubicin Epirubicin Idarubicin Mitomycin Paclitaxel Treosulfan Vinblastine Vincristine Vinorelbine Hyperosmolar agents Total parenteral nutrition >10% dextrose Mannitol 15% Other Radiographic contrast media Promethazine (phenergan) Diazepam Digoxin ( ) This is not an exhaustive list. Risk factors for infiltration and extravasation Risk factors

2014 Publication 1593

165. Tools for Assessing Outcomes in Studies of Chronic Cough

. 2012 ; 13 : 118 . 12. B a r t o n A , Ga y dec ki P , H o l t K , S mi t h J A . D a t a r e d uc t io n f o r co ug h stud ies using distribution of audio frequency content . Cough . 2012 ; 8 ( 1 ): 12 . 13. B h at t a c h a r y a M , Jo s h i N , Y a d a v S . T o c o mp a r e t h e e f f e c t o f dextromethorphan, promethazine and placebo on nocturnal cough in children aged 1-12 y with upper respiratory infections: a randomized controlled trial . Indian J Pediatr . 2013 ; 80 ( 11 ): 891 - 895

2015 American College of Chest Physicians

166. Management of AML in Pregnancy

treatment. According to the UK Teratology Information Service (UKTIS), the first choice antiemetic drugs are the antihistamines, cyclizine and promethazine (UKTIS ). Prochlorperazine and metoclopromide are considered second line agents because they may be associated with maternal dystonic reactions (UKTIS ). Ondansetron can be used in cases where first and second line antiemetic therapies have been unsuccessful (Einarson et al , ). Antibiotics Patients usually suffer severe neutropenia either

2015 British Committee for Standards in Haematology

170. Controversies in Migraine Management

, antiemetics (chlorpromazine, droperidol, metoclopramide, prochlorperazine, promethazine), dexamethasone, and opioids (meperidine, tramadol, nalbuphine). 32-35 Ketorolac is the preferred first-line agent because of its minimal side effects and at least eight randomized trials demonstrating equivalence or superiority to parenteral sumatriptan and the antiemetics. The evidence about opioids will be discussed in detail in the evidence review. Antiemetic therapy, such as metoclopramide, can facilitate the use

2014 California Technology Assessment Forum

171. Chemical and Environmental Restraints in Acute and Long-Term Care: Guidelines

: PM23152276 16. Zeller SL, Rhoades RW. Systematic reviews of assessment measures and pharmacologic treatments for agitation. Clin Ther. 2010 Mar;32(3):403-25. PubMed: PM20399981 17. Huf G, Alexander J, Allen MH, Raveendran NS. Haloperidol plus promethazine for psychosis-induced aggression. Cochrane Database Syst Rev. 2009;(3):CD005146. PubMed: PM19588366 18. Lonergan E, Luxenberg J. Valproate preparations for agitation in dementia. Cochrane Database Syst Rev. 2009;(3):CD003945. PubMed: PM19588348 Review

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

172. Clinical management of nausea and vomiting in pregnancy and hyperemesis gravidarum across primary and secondary care: a population based study. (PubMed)

and antiemetic prescribing increased continuously during 1998-2013 (trend p<0.001). Younger age, deprivation, Black/Asian/Mixed ethnicity, multiple-pregnancy were associated with NVP/HG generally across all levels, but associations were strongest for hospital admissions. Most comorbidities had patterns of association with NVP/HG levels. Among women with NVP/HG who had no hospital admissions, 49% were prescribed antiemetics, mainly from first line treatment (21% prochlorperazine, 15% promethazine, 13

2019 BJOG

173. Severe Viperidae envenomation complicated by a state of shock, acute kidney injury, and gangrene presenting late at the emergency department: a case report. (PubMed)

), coagulopathy, renal impairment, and gangrene of the entire right upper limb. Emergency management consisted of fluid resuscitation, repeated boluses of adrenaline, a total of three vials of polyvalent anti-venom sera, promethazine, analgesics, corticosteroids, and administration of fresh frozen plasma. Within four hours of emergency department hospitalisation she developped signs of sepsis and persistent hypotension refractory to fluid resuscitation, suggestive of an associated septic shock. Management

2019 BMC Emergency Medicine

174. Current sedation practices in paediatric audiology clinics in gauteng, South Africa. (PubMed)

at the outpatient clinic was mostly conducted by a registered nurse/an Ear, Nose & Throat specialist, with the anaesthesiologist serving in this role for AEP testing in theatre under general anaesthesia. Oral chloral hydrate and promethazine are the most commonly used medications, with melatonin also listed for conscious sedation. Propofol is the most commonly used for AEP testing in theatre. Three challenges were identified and these add to the implications raised by current findings.Current findings have

2019 International Journal of Pediatric Otorhinolaryngology

175. Efficacy of bupivacaine infiltration in preventing haemodynamic changes during craniotomy. (PubMed)

with morphine and promethazine and were anaestetised using conventional general anaesthesia technique including 02, N20 vecuronium and morphine. Ventilation was controlled so as to maintain PaCO2 between 25-30 mm Hg. EKG, heart rate and direct arterial pressure were monitored at various events during craniotomy. In control group there was a statistically significant increase in systolic arterial pressure and heart rate after scalp infiltration, scalp incision, during scalp flap reflection, burr hole

2019 Neurology India Controlled trial quality: uncertain

176. The Use of Rapid Tranquilization in Aggressive Behavior. (PubMed)

, e.g., when the patient is intoxicated with alcohol or suffers from a pre-existing disease. Haloperidol has a relatively weak effect on aggression when given alone and can also cause side effects such as early dyskinesia and epileptic seizures. It should, therefore, no longer be used as monotherapy. On the other hand, haloperidol combined with benzodiazepines or promethazine and monotherapy with lorazepam, olanzapine, ziprasidone, or aripiprazole intramuscular are effective options

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2019 Deutsches Arzteblatt international

177. Anti-inflammatory activity of herb products from Licania rigida Benth. (PubMed)

-induced paw edema models and the animals were orally treated (p.o.) with EHFLR at doses of 25, 50, 100 mg/kg, indomethacin (10 mg/kg) for carrageenan-induced paw edema and promethazine (6 mg/kg) for dextran-induced paw edema. The possible mechanisms involved in the anti-inflammatory action of the extract were evaluated by the paw edema models induced by histamine and arachidonic acid, and by the model of carrageenan-induced peritonitis, where vascular permeability and leukocyte migration

2019 Complementary Therapies In Medicine

180. Chronic Insomnia in Older Adults

of hypnotic activity & substantial suppression of delta & REM sleep. 1 Insomnia in Older Adults continued For more detailed medication information, see the RxFiles Drug Comparison Charts Drug or Drug Class When a medication could be problematic for Older Adults 1-4 Clinical Conern 1-4 Medications used to treat insomnia & their precautions ANTIHISTAMINES, FIRST GENERATION (As single agent or as part of a combination product) B =65 YEARS OF AGE QE = High (Hydroxyzine & Promethazine) Moderate (All others (...) ); SR = Strong Chlorpheniramine CHLOR-TRIPOLON Clemastine Cyproheptadine PERIACTIN Dimenhydrinate GRAVOL Diphenhydramine (oral) BENADRYL ? Denotes a combination product Doxylamine DICLECTIN ? Hydroxyzine ATARAX Promethazine PHENERGAN Triprolidine S USE FOR >1 WEEK of 1 st generation antihistamines • Sedation & strong anticholinergic side effects ( ? risk of confusion, dry mouth, constipation, urinary retention in ? & other anticholinergic effects/toxicity) • Clearance ? with advanced age & tolerance

2013 RxFiles

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