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Promethazine

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161. NK Cells Infusion for Advanced Malignancies

: NK cells infusion Pretreatment:patients enrolled in this study will receive 20 mg/kg of cyclophosphamide for solid tumor or 20-60 mg/kg of cyclophosphamide for hematological tumor once daily for 3 times. NK cells infusion is allowed within 2-14 days after treatment. NK cells infusion:30-60 minutes before infusion,ant-allergic agents are applied (promethazine 25mg,i.m. ; Cimetidine 0.4g i.v. ; diphenhydramine 50mg po.). NK cells are intravenously infused into patients with 15-30 minutes every

2018 Clinical Trials

162. TREC-Lebanon: A Trial for Rapid Tranquilisation for Agitated Patients in the Emergency Setting

: Recruiting First Posted : August 21, 2018 Last Update Posted : October 25, 2018 See Sponsor: Joseph Dib Collaborators: University of Nottingham Hopital Psychiatrique De La Croix Information provided by (Responsible Party): Joseph Dib, Hopital Psychiatrique De La Croix Study Details Study Description Go to Brief Summary: This is a randomised controlled trial comparing haloperidol + promethazine versus haloperidol + promethazine + chlorpromazine for agitated patients in the emergency department. Condition (...) or disease Intervention/treatment Phase Psychiatric Emergency Aggression Agitation Drug: Haloperidol + Promethazine + Chlorpromazine Drug: Haloperidol + Promethazine Phase 4 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 100 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: TREC-Lebanon Trial: A Randomised Controlled

2018 Clinical Trials

163. A Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache

Device Product: No Product Manufactured in and Exported from the U.S.: No Keywords provided by Lakeland Health: acetaminophen ketorolac prochlorperazine diphenhydramine Additional relevant MeSH terms: Layout table for MeSH terms Emergencies Headache Disease Attributes Pathologic Processes Pain Neurologic Manifestations Signs and Symptoms Acetaminophen Ketorolac Ketorolac Tromethamine Diphenhydramine Prochlorperazine Promethazine Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral

2018 Clinical Trials

164. Gelclair at Conditioning or After Oral Mucositis Diagnosed vs. Magic Mouth Wash in Stem Cell Transplant Recipients

for MeSH terms Mucositis Stomatitis Gastroenteritis Gastrointestinal Diseases Digestive System Diseases Mouth Diseases Stomatognathic Diseases Diphenhydramine Lidocaine Promethazine Magnesium Hydroxide Aluminum hydroxide, magnesium hydroxide, drug combination Simethicone Hyaluronic Acid Antacids Povidone Sleep Aids, Pharmaceutical Hypnotics and Sedatives Central Nervous System Depressants Physiological Effects of Drugs Anesthetics, Local Anesthetics Sensory System Agents Peripheral Nervous System

2018 Clinical Trials

165. A Study to Assess the Safety and the Efficacy of IV Fosnetupitant/Palonosetron (260 mg/0.25 mg) Combination Compared to Oral Netupitant/Palonosetron (300 mg/0.5 mg) Combination for the Prevention of CINV in AC Chemotherapy in Women With Breast Cancer

) NK1 receptor antagonists (e.g., aprepitant, fosaprepitant, rolapitant or any other new drug of this class) benzamides (e.g., metoclopramide, alizapride) phenothiazines (e.g., prochlorperazine, promethazine, fluphenazine, perphenazine, thiethylperazine, chlorpromazine) benzodiazepines (except if the subject is receiving such medication for sleep or anxiety and has been on a stable dose for at least seven days prior to Day 1). butyrophenones (e.g., haloperidol, droperidol) anticholinergics (e.g

2018 Clinical Trials

166. Therapeutic Rest in Early Labor, A Study on Morphine Sleep.

examine the potential benefits of therapeutic rest from the perspective of either patient satisfaction or cost-effectiveness. The investigators aim to determine whether therapeutic rest using morphine and promethazine is associated with variations in obstetric or neonatal outcomes, patient satisfaction, or costs of labor admission. Methods: This will be a prospective cohort study. Women who are eligible for therapeutic rest (reactive non-stress test, normal amniotic fluid, in prodromal or early labor (...) Sulfate Patients accepted morphine and promethazine as a method for pain management in early or prodromal labor. Drug: Morphine Sulfate Morphine sulfate and promethazine Other Name: Morphine Sleep Declined Morphine Sulfate Patients declined morphine and promethazine as a method for pain management in early or prodromal labor. Outcome Measures Go to Primary Outcome Measures : Time from hospital admission to delivery of baby [ Time Frame: 1-2 weeks after admission to hospital ] Mean hours from time

2018 Clinical Trials

167. Delirium Prevention Protocol in Elderly Patients

fentanyl usage intraoperatively Intubation + general anesthesia adjunct total: 1-2 mcg/kg fentanyl Sedation: 0-0.24 mcg/kg fentanyl Post-operative: 0.5 - 1 mcg/kg fentanyl Avoid morphine Avoid ketamine Avoid diphenhydramine, dexamethasone, scopolamine, metoclopramide, and promethazine Avoid H2-blockers (cimetidine, ranitidine, famotidine) Avoid polypharmacy intraoperatively if possible (i.e. > 5 new medications) Fluid repletion based on maintenance and losses Other: Preventative Delirium Protocol

2018 Clinical Trials

168. Safety and Antiemetic Efficacy of Akynzeo Plus Dexamethasone During Radiotherapy and Concomitant Weekly Cisplatin

/ benzamide derivatives (e.g., metoclopramide, alizapride). Benzodiazepines (except if the patient is receiving such medication for sleep or anxiety and has been on a stable dose for at least seven days prior to the first dose of study medications). Phenothiazines (e.g., prochlorperazine, promethazine, metopimazine, fluphenazine, perphenazine, thiethylperazine, chlorpromazine). Butyrophenone (e.g., haloperidol, droperidol). Corticosteroids (e.g., dexamethasone, methylprednisolone, prednisolone

2018 Clinical Trials

169. Omnitram Safety and Efficacy in the Treatment of Diabetic Neuropathy

antidepressants and other tricyclic drugs including cyclobenzaprine and promethazine; triptans; 5-HT3 receptor antagonists; neuroleptics. Use of benzodiazepines or other central nervous system depressants including non-benzodiazepine sedative hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics within 14 days of Segment 1, Study Day 1, or during the study. Use of opiates, including tramadol, within 28 days of Segment 1, Study Day 1, or during the study. Use of all other

2018 Clinical Trials

170. Treatment of Nighttime Pruritus in Atopic Dermatitis

: Yes Studies a U.S. FDA-regulated Device Product: No Product Manufactured in and Exported from the U.S.: Yes Additional relevant MeSH terms: Layout table for MeSH terms Dermatitis Dermatitis, Atopic Eczema Pruritus Skin Diseases Skin Diseases, Genetic Genetic Diseases, Inborn Skin Diseases, Eczematous Hypersensitivity, Immediate Hypersensitivity Immune System Diseases Skin Manifestations Signs and Symptoms Melatonin Diphenhydramine Promethazine Antioxidants Molecular Mechanisms of Pharmacological

2018 Clinical Trials

171. A Pharmacokinetic Trial of Naproxen Sodium and Diphenhydramine Hydrochloride Soft Capsules Versus Naproxen Sodium and Diphenhydramine Hydrochloride Tablets in Healthy Adult Subjects Under Fed Conditions

terms Naproxen Diphenhydramine Promethazine Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Gout Suppressants Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Sleep Aids, Pharmaceutical Hypnotics and Sedatives Central Nervous System Depressants Anesthetics, Local Anesthetics Antiemetics Autonomic

2018 Clinical Trials

172. Post Operative Pain Control After Pediatric Hip Surgery

to Share IPD: No Additional relevant MeSH terms: Layout table for MeSH terms Pain, Postoperative Postoperative Complications Pathologic Processes Pain Neurologic Manifestations Signs and Symptoms Morphine Fentanyl Oxycodone Acetaminophen Ropivacaine Ondansetron Diphenhydramine Lorazepam Promethazine Analgesics, Opioid Narcotics Central Nervous System Depressants Physiological Effects of Drugs Analgesics Sensory System Agents Peripheral Nervous System Agents Adjuvants, Anesthesia Anesthetics

2018 Clinical Trials

173. The pharmacological management of acute behavioural disturbance: Data from a clinical audit conducted in UK mental health services. (PubMed)

behaviour. A benzodiazepine alone was administered in 60% of the 1091 episodes where oral medication only was used and in 39% of the 1081 episodes where parenteral medication (rapid tranquillisation) was used. Haloperidol was combined with lorazepam in 22% of rapid tranquillisation episodes and with promethazine in 3%. Physical violence towards others was strongly associated with receiving rapid tranquillisation in men (odds ratio 1.74, 1.25-2.44; p<0.001) as was actual or attempted self-harm in women (...) to a quarter of episodes. The most common rapid tranquillisation combination used was lorazepam and haloperidol, for which the randomised controlled trial evidence is very limited. Rapid tranquillisation prescribing practice was not wholly consistent with the relevant National Institute for Health and Care Excellence guideline, which recommends intramuscular lorazepam on its own or intramuscular haloperidol combined with intramuscular promethazine. Clinical factors prompting the use of rapid

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2018 Journal of psychopharmacology (Oxford, England)

174. Evaluation of the effects of anti-motion sickness drugs on subjective sleepiness and cognitive performance of healthy males. (PubMed)

Evaluation of the effects of anti-motion sickness drugs on subjective sleepiness and cognitive performance of healthy males. This study aimed to investigate the clinical and cognitive side effects of baclofen (10 mg), meclizine (25 mg), dimenhydrinate (40 mg) plus cinnarizine (25 mg) and promethazine (25 mg) plus d-amphetamine (10 mg). The study had a double-blind, placebo controlled, repeated measures design and was conducted on healthy male volunteers. The psychomotor vigilance test (...) an influence of these drugs on the working memory. Significant side effects for baclofen were: sleepiness, tiredness, blurred vision, concentration problems and dizziness whereas for dimenhydrinate-cinnarizine only sleepiness and blurred vision were reported. Meclizine decreased the accuracy on the Sternberg working memory task and thus seemed to affect short-term memory. A reported side effect was increased sleepiness. Promethazine plus d-amphetamine did not affect any of the tested cognitive functions

2018 Journal of psychopharmacology (Oxford, England)

175. Design of a treatment pathway for insomnia in prison settings in England: a modified Delphi study. (PubMed)

statements of contention that comprised concerns over the inclusion of sleep observations, sleep restriction therapy and promethazine. Consensus was high (>80%). Thirteen stakeholders agreed the final pathway in round 3. The final treatment pathway comprised a standardised stepped-care approach for insomnia in prison populations. The pathway resulted in five main stages: (1) transition from community; (2) detection and assessment; (3) treatment for short-term insomnia; (4) treatment for long-term

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2018 BMJ open

179. Common cold

and pholcodine). Expectorants (guaifenesin and ipecacuanha). Topical and oral decongestants (ephedrine, oxymetazoline, phenylephrine, pseudoephedrine, and xylometazoline). Antihistamines (brompheniramine, chlorphenamine, diphenhydramine, doxylamine, promethazine, and triprolidine). Simple cough remedies (containing glycerine, honey, or lemon) are still licensed for use. Alternatively, for children over the age of one year, a warm drink of honey and lemon could be given. [ ; ; ; ; ; ; ] Basis

2016 NICE Clinical Knowledge Summaries

180. Relative Efficacy of Seven Common H1 Receptor Antagonist Antihistamines in Chronic Idiopathic Urticaria. (PubMed)

, chlorpheniramine, embramine, promethazine, dimeth'mdene and dexchlorpheniramme. The differences between the first five antihistamines were not statistically significant, though these were superior to ddxchlorpheniralmine and placebo. Dexchlorpheniramine was statistically better than placebo.

2017 Indian journal of dermatology, venereology and leprology

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