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143. Management of schizophrenia

% with the most frequent adverse effects being headache, nausea and dizziness. The somnolence rate was =7%, the frequency of injection site reactions less than 5%, dystonia less than 2% and less than 5.5% of participants experienced akathisia. Aripiprazole has been associated with an increased risk of sudden death in elderly people with dementia-related psychosis and with orthostatic hypotension. 119 Systematic reviews have examined intramuscular (IM) olanzapine 120 and haloperidol plus promethazine 121 (...) for psychosis related agitation or aggression. Based on four high quality studies it was concluded that haloperidol plus promethazine was a safe and swift treatment for psychosis related agitation or aggression, whereas use of benzodiazepines alone, such as lorazepam and particularly midazolam was difficult to justify partly due to concerns over respiratory depression. Haloperidol alone led to more movement disorder adverse effects. 117 5 • Pharmacological and related approaches 1 ++ 4 4 1 ++ 1 + 1 ++22

2013 SIGN

144. Management of AML in Pregnancy (Full text)

treatment. According to the UK Teratology Information Service (UKTIS), the first choice antiemetic drugs are the antihistamines, cyclizine and promethazine (UKTIS ). Prochlorperazine and metoclopromide are considered second line agents because they may be associated with maternal dystonic reactions (UKTIS ). Ondansetron can be used in cases where first and second line antiemetic therapies have been unsuccessful (Einarson et al , ). Antibiotics Patients usually suffer severe neutropenia either

2015 British Committee for Standards in Haematology PubMed

146. Strategies for discontinuing benzodiazepines

are marketed for this indi- cation. The most frequent agents used include diphen- hydramine, clorpheniramine, promethazine, hydroxizine and doxilamine. 39 An abrupt withdrawal of the drug can cause rebound insomnia. 40 Definitively their numerous anticholinergic side effects, the possibility of cognitive alterations, daytime somno- lence, accumulation of those with long elimination half- lives, and uncertainty about optimal dosing for insomnia, makes their harm-benefit relationship unfavourable, especially

2015 Drug and Therapeutics Bulletin of Navarre (Spain)

148. Methadone Safety (Full text)

Interactions D rug E ffects on M ethadone L evels ∗ E ffects on QT c I nterval A dditive S edative or R espiratory D epressant E ffects Antibiotics Ciprofloxacin ↑ Clarithromycin ↑ ↑ Erythromycin ↑ ↑ Itraconazole ↑ Ketoconazole ↑ Fluconazole ↑ Rifampin ↓ Telithromycin ↑ Anticonvulsants Carbamazepine ↓ Phenytoin ↓ Antihistamines Diphenhydramine ↑ Promethazine ↑ Antipsychotics Quetiapine ↑ ↑ Barbiturates Phenobarbital ↓ ↑ Benzodiazepines Alprazolam ↑ ↑ Clorazepate ↑ ↑ Diazepam ↑ ↑ Estazolam ↑ ↑ Flurazepam

2014 American Pain Society PubMed

149. Chronic Insomnia in Older Adults

of hypnotic activity & substantial suppression of delta & REM sleep. 1 Insomnia in Older Adults continued For more detailed medication information, see the RxFiles Drug Comparison Charts Drug or Drug Class When a medication could be problematic for Older Adults 1-4 Clinical Conern 1-4 Medications used to treat insomnia & their precautions ANTIHISTAMINES, FIRST GENERATION (As single agent or as part of a combination product) B =65 YEARS OF AGE QE = High (Hydroxyzine & Promethazine) Moderate (All others (...) ); SR = Strong Chlorpheniramine CHLOR-TRIPOLON Clemastine Cyproheptadine PERIACTIN Dimenhydrinate GRAVOL Diphenhydramine (oral) BENADRYL ? Denotes a combination product Doxylamine DICLECTIN ? Hydroxyzine ATARAX Promethazine PHENERGAN Triprolidine S USE FOR >1 WEEK of 1 st generation antihistamines • Sedation & strong anticholinergic side effects ( ? risk of confusion, dry mouth, constipation, urinary retention in ? & other anticholinergic effects/toxicity) • Clearance ? with advanced age & tolerance

2013 RxFiles

150. Extravasation and infiltration

Calcium gluconate 10% Potassium chloride 7.45% Sodium bicarbonate 4.2% & 8.4% Sodium chloride 10% Cytotoxic agents Busulphan Actinomycin-D Daunorubicin Doxorubicin Epirubicin Idarubicin Mitomycin Paclitaxel Treosulfan Vinblastine Vincristine Vinorelbine Hyperosmolar agents Total parenteral nutrition >10% dextrose Mannitol 15% Other Radiographic contrast media Promethazine (phenergan) Diazepam Digoxin ( ) This is not an exhaustive list. Risk factors for infiltration and extravasation Risk factors

2014 Great Ormond Street Hospital

152. Controversies in Migraine Management

, antiemetics (chlorpromazine, droperidol, metoclopramide, prochlorperazine, promethazine), dexamethasone, and opioids (meperidine, tramadol, nalbuphine). 32-35 Ketorolac is the preferred first-line agent because of its minimal side effects and at least eight randomized trials demonstrating equivalence or superiority to parenteral sumatriptan and the antiemetics. The evidence about opioids will be discussed in detail in the evidence review. Antiemetic therapy, such as metoclopramide, can facilitate the use

2014 California Technology Assessment Forum

154. Chemical and Environmental Restraints in Acute and Long-Term Care: Guidelines

: PM23152276 16. Zeller SL, Rhoades RW. Systematic reviews of assessment measures and pharmacologic treatments for agitation. Clin Ther. 2010 Mar;32(3):403-25. PubMed: PM20399981 17. Huf G, Alexander J, Allen MH, Raveendran NS. Haloperidol plus promethazine for psychosis-induced aggression. Cochrane Database Syst Rev. 2009;(3):CD005146. PubMed: PM19588366 18. Lonergan E, Luxenberg J. Valproate preparations for agitation in dementia. Cochrane Database Syst Rev. 2009;(3):CD003945. PubMed: PM19588348 Review

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

155. Topical Transdermally Delivered Lidocaine and Benzocaine Compared to Compounded Lidocaine/Tetracaine During Microfocused Ultrasound With Visualization Treatment. (PubMed)

%/tetracaine 7% (23/7) to mitigate discomfort during MFU-V treatment.This was a randomized, double-blinded, split-face study. One hour before MFU-V, subjects (N=14 females) received 50 mg IM meperidine/25 mg IM promethazine/5 mg oral diazepam. Fifteen minutes before treatment, 1 side of the face was treated with 1 application of 4% lidocaine, followed by 1 application of 20% benzocaine; the contralateral side was treated with 2 applications of 23/7 (to maintain blinding). Numbness was assessed by blinded

2018 Journal of drugs in dermatology : JDD

156. Palliative sedation in Germany: factors and treatment practices associated with different sedation rate estimates in palliative and hospice care services. (Full text)

and Chi2/ Fisher Exact Tests and considered significant (*) at two-sided p < .05.Organisations in group B report that they discuss PS for a higher proportion of patients (38.5%/10.2%, p < 0.000**), rate agitation more often as an indications for PS (78.9%/ 53.5%, p = 0.050*), and are more likely to use Lorazepam (63.2%/ 37.4%, p = 0.047*), Promethazin (26.3%/ 9.6%, p = 0.044*), and (Es-)Ketamin (31.6%/ 12.8%, p = 0.039*) than representatives in group A. Both groups differ significantly

2018 BMC Palliative Care PubMed

157. A Pharmacokinetic Trial of Naproxen Sodium and Diphenhydramine Hydrochloride Soft Capsules Versus Naproxen Sodium and Diphenhydramine Hydrochloride Tablets in Healthy Adult Subjects

Promethazine Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Gout Suppressants Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Sleep Aids, Pharmaceutical Hypnotics and Sedatives Central Nervous System Depressants Anesthetics, Local Anesthetics Antiemetics Autonomic Agents Gastrointestinal Agents Histamine

2018 Clinical Trials

158. A Study of Lasmiditan on Simulated Driving Performance in Healthy Participants

Last Update Posted: July 13, 2018 Last Verified: July 2018 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: Yes Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Diphenhydramine Promethazine Sleep Aids, Pharmaceutical Hypnotics and Sedatives Central Nervous System Depressants Physiological Effects of Drugs Anesthetics, Local Anesthetics Sensory System Agents Peripheral Nervous System Agents Antiemetics

2018 Clinical Trials

159. Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review. (Full text)

the 14-day study period, trend in vomiting scores was better in the ondansetron group (P = .042). One RCT (n = 159) found no difference between metoclopramide and promethazine after 24 hours (episodes of vomiting, 1 [IQR, 0-5] for metoclopramide vs 2 [IQR, 0-3] for promethazine [P = .81], VAS [0-10 scale] for nausea, 2 [IQR, 1-5] vs 2 [IQR, 1-4], respectively [P = .99]). Three RCTs compared corticosteroids with placebo or promethazine or metoclopramide in women with severe symptoms. Improvements were (...) seen in all corticosteroid groups, but only a significant difference between corticosteroids vs metoclopramide was reported (emesis reduction, 40.9% vs 16.5% at day 2; 71.6% vs 51.2% at day 3; 95.8% vs 76.6% at day 7 [n = 40, P < .001]). For other interventions, evidence was limited.For mild symptoms of nausea and emesis of pregnancy, ginger, pyridoxine, antihistamines, and metoclopramide were associated with greater benefit than placebo. For moderate symptoms, pyridoxine-doxylamine, promethazine

2016 JAMA PubMed

160. Imaging 5HT7 Antagonist Effects in Bipolar Disorder

, perhexiline, phenacetin, phenformin, promethazine, propafenone, propranolol, sparteine, tamoxifen, tramadol, venlafaxine. Participants planning to use these medications after their participation in the study must commit to a two-week washout period at the end of the study before commencing these medications. As JNJ-18038683 is a moderate inhibitor of cytochrome P450 2C19, use of the following CYP2C19 substrates will be an exclusion: Proton pump inhibitors, phenytoin, phenobarbitone, diazepam, Norphenytoin

2018 Clinical Trials

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