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Promethazine

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121. Double-blind comparison of granisetron, promethazine, or a combination of both for the prevention of postoperative nausea and vomiting in females undergoing outpatient laparoscopies. (PubMed)

Double-blind comparison of granisetron, promethazine, or a combination of both for the prevention of postoperative nausea and vomiting in females undergoing outpatient laparoscopies. Postoperative nausea and vomiting (PONV) and postdischarge nausea and vomiting (PDNV) are common problems after surgery. Prophylactic combination antiemetic therapy is recommended for patients at high risk for developing PONV and PDNV. Granisetron, a serotonin antagonist, is an effective antiemetic that is devoid (...) of sedative side effect. Although promethazine is effective, commonly used doses are associated with sedation. This study investigates the combination of low doses of granisetron and promethazine for the prevention of PONV.Women undergoing ambulatory gynecological laparoscopy were enrolled. A standard general anesthetic regimen was prescribed. Fifteen minutes before the expected end of surgery, the patients were randomly assigned to receive granisetron 0.1 mg iv, promethazine 6.25 mg iv, or a combination

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2009 Canadian journal of anaesthesia = Journal canadien d'anesthesie

122. Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV. (PubMed)

Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV. Frequently, patients identified as high risk for postoperative nausea and vomiting (PONV) are treated prophylactically with intravenous (IV) ondansetron and postoperatively with IV promethazine. The purpose of this study was to determine if using an aromatic therapy of 70% isopropyl alcohol (IPA) would be more (...) effective than promethazine in resolution of breakthrough PONV symptoms in groups of high-risk patients administered prophylactic ondansetron. All subjects enrolled were identified as high risk for PONV, administered general anesthesia and a prophylactic antiemetic of 4 mg of IV ondansetron, and randomized to receive IPA or promethazine for treatment of breakthrough PONV Demographics, verbal numeric rating scale (VNRS) scores for nausea, time to 50% reduction in VNRS scores, and overall antiemetic

2009 AANA journal

123. [Haloperidol plus promethazine for agitated patients--a systematic review]. (PubMed)

[Haloperidol plus promethazine for agitated patients--a systematic review]. Rapid and safe tranquillisation is sometimes unavoidable. We conducted this systematic review to determine the value of the combination haloperidol plus promethazine, frequently used in Brazil.We searched the Cochrane Schizophrenia Group's Register and included all randomised clinical trials involving aggressive people with psychosis for which haloperidol plus promethazine was being used. We reliably selected, quality (...) assessed and extracted data from all relevant studies.We identified four relevant high quality studies. The combination haloperidol plus promethazine mix was compared with midazolam, lorazepam, haloperidol alone and olanzapine Intramuscular. In Brazil, haloperidol plus promethazine was effective with over 2/3 of people being tranquil by 30 minutes, but midazolam was more swift and in India, compared with lorazepam, the combination was more effective. Over the next few hours reported differences

2009 Revista brasileira de psiquiatria (São Paulo, Brazil : 1999)

124. Haloperidol plus promethazine for psychosis-induced aggression. (PubMed)

Haloperidol plus promethazine for psychosis-induced aggression. Health services often manage agitated or violent people, and for emergency psychiatric services such behaviour is particularly prevalent (10%). The drugs used in this situation should ensure that the person swiftly and safely regains composure.To examine whether haloperidol plus promethazine is an effective treatment for psychosis induced agitation/aggression.We searched the Cochrane Schizophrenia Group's Register (January 2008).We (...) included all randomised clinical trials involving aggressive people with psychosis for which haloperidol plus promethazine was being used.We reliably selected, quality assessed and extracted data from all relevant studies. For binary outcomes we calculated standard estimations of risk ratio (RR) and their 95% confidence intervals (CI). Where possible we estimated weighted number needed to treat or harm (NNT/H).We identified four relevant high quality studies. One compared the haloperidol plus

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2009 Cochrane database of systematic reviews (Online)

125. Fluid and pharmacological agents for adhesion prevention after gynaecological surgery. (PubMed)

and pharmacological agents used as adjuvants in preventing formation of adhesions after gynaecological surgery.The following databases were searched up to April 2014: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and PsycINFO. Studies involving hydroflotation, gel and such pharmacological agents as steroids, noxytioline, heparin, promethazine, N,O-carboxymethyl chitosan and gonadotrophin-releasing hormone agonists were

2014 Cochrane

126. Treatment-Related Nausea and Vomiting (PDQ®): Health Professional Version

doses of a drug are to be given. Table 3. Prevention of Acute or Delayed CINV Drug Category Medication Dose Available Route Comment(s) Reference(s) Dopamine antagonists: phenothiazines Chlorpromazine 10–25 mg PO q4–6h PO, IM Prolongs QT interval [ , ][ ] 25–50 mg IM q3–4h Prochlorperazine 25 mg PR q12h PO, IM, IV, PR Less sedation, but increased risk of EPS [ ] 5–10 mg PO/IM/IV q6–8h Promethazine 12.5–25 mg q4–6h PO, IM, IV, PR Vesicant [ ][ ] Weak antiemetic Dopamine antagonists: butyrophenones

2018 PDQ - NCI's Comprehensive Cancer Database

127. Use of Antipsychotics and/or Benzodiazepines as Rapid Tranquilization in In-Patients of Mental Facilities and Emergency Departments: A Review of the Clinical Effectiveness and Guidelines

of antipsychotics and benzodiazepines, with some studies suggesting they are similar, while others favouring one treatment over another. One notable exception, however, is that there appears to be relatively consistent evidence that intramuscular haloperidol is less effective and more harmful than other therapies. One guideline suggests using IM lorazepam or a combination of IM haloperidol and promethazine as rapid tranquilization for adults in in-patient psychiatric or emergency department settings, and IM

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

129. Drugs to avoid in 2015

this isoenzyme (Rev Prescrire n° 337). It is far more prudent to choose a non-sedative and non-antimuscarinic antihistamine such as loratadine or ceti- rizine. – Injectable promethazine, an antihista- mine used to treat severe urticaria, can cause thrombosis, skin necrosis and gan- grene following extravasation or inad- vertent injection into an artery (Rev Prescrire n° 327). It is more prudent to use injectable dexchlorpheniramine, which does not appear to carry these risks (1). Diabetes - Nutrition

2015 Prescrire

132. Is the Use of Haloperidol a Safe and Effective Method of Tranquilization for Patients With Psychosis-Induced Aggression or Agitation?

: a multicenter, randomized, double-blind, placebo- controlled trial. Ann Emerg Med. 2013;61:72-81. 4. Lukens TW, Wolf SJ, Edlow JA, et al. Clinical policy: critical issues in the diagnoses and management of adult psychiatric patient in theemergencydepartment.AnnEmergMed. 2006;46:79-99. 5. Barbui C. Intramuscular haloperidol plus promethazine is more effective and safer than haloperidol alone for rapid tranquillisation of agitated mentally ill patients. Evid Based Ment Health. 2008;11:86-87. 6. Huf G (...) , Coutinho ES, Adams CE. Rapid tranquillisation in psychiatric emergency settings in Brazil: pragmatic randomised controlled trial of intramuscular haloperidol versus intramuscular haloperidol plus promethazine. BMJ. 2007;335:869. 7. Andrezina R, Josiassen RC, Marcus RN, et al. Intramuscular aripiprazole for the treatment of acute agitation in patients with schizophrenia or schizoaffective disorder: a double-blind, placebo-controlled comparison with intramuscular haloperidol. Psychopharmacology (Berl

2014 Annals of Emergency Medicine Systematic Review Snapshots

134. The economic burden of inpatient care of depression in Poznan (Poland) and Kiel (Germany) in 2016. (PubMed)

by the length of hospital stay, giving the cost of hospitalization. The annual cost of inpatient care of depression in 2016 was EUR 491,067.19 ([Formula: see text]) in Poznan and EUR 2,847,991.00 [Formula: see text] in Kiel. In Poznan, hospitalization was underfunded reaching EUR 183,042.55 (37.27% of total costs in Poznan). In Poznan, the most frequently prescribed medicine was quetiapine, followed by olanzapine and venlafaxine, whereas in Kiel it was venlafaxine, followed by mirtazapine and promethazine

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2018 PLoS ONE

135. Clinical management of nausea and vomiting in pregnancy and hyperemesis gravidarum across primary and secondary care: a population based study. (PubMed)

and antiemetic prescribing increased continuously during 1998-2013 (trend p<0.001). Younger age, deprivation, Black/Asian/Mixed ethnicity, multiple-pregnancy were associated with NVP/HG generally across all levels, but associations were strongest for hospital admissions. Most comorbidities had patterns of association with NVP/HG levels. Among women with NVP/HG who had no hospital admissions, 49% were prescribed antiemetics, mainly from first line treatment (21% prochlorperazine, 15% promethazine, 13

2019 BJOG

136. Current sedation practices in paediatric audiology clinics in gauteng, South Africa. (PubMed)

at the outpatient clinic was mostly conducted by a registered nurse/an Ear, Nose & Throat specialist, with the anaesthesiologist serving in this role for AEP testing in theatre under general anaesthesia. Oral chloral hydrate and promethazine are the most commonly used medications, with melatonin also listed for conscious sedation. Propofol is the most commonly used for AEP testing in theatre. Three challenges were identified and these add to the implications raised by current findings.Current findings have

2019 International Journal of Pediatric Otorhinolaryngology

138. Palliative care - oral

(opioid) Morphine, oxycodone Antidepressants (tricyclics) Amitriptyline, clomipramine Antidepressants (selective serotonin reuptake inhibitors) Citalopram, fluoxetine Antiemetics Hyoscine hydrobromide Antiepileptics Carbamazepine, gabapentin Antihistamines (sedating) Chlorphenamine, promethazine Antimanics Lithium carbonate, lithium citrate Antiparkinsons Orphenadrine, procyclidine Antipsychotics Olanzapine Antispasmodics Oxybutynin, solifenacin Beta-blockers Atenolol, propranolol Diuretics Furosemide

2017 NICE Clinical Knowledge Summaries

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