How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

939 results for

Promethazine

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

41. Antiemetic efficacy of promethazine on xylazine-induced emesis in cats Full Text available with Trip Pro

Antiemetic efficacy of promethazine on xylazine-induced emesis in cats The prophylactic antiemetic effect of 3 dosages of promethazine injected into cats 1 h before administration of xylazine was compared with that of a saline solution. Prior treatment with 2 and 4 mg/kg of promethazine significantly reduced the frequency of emetic episodes. Promethazine may be used as a prophylactic antiemetic in cats treated with xylazine.

2012 The Canadian Veterinary Journal

42. Peripheral Sympathectomy as a Novel Treatment Option for Distal Digital Necrosis Following Parenteral Administration of Promethazine Full Text available with Trip Pro

Peripheral Sympathectomy as a Novel Treatment Option for Distal Digital Necrosis Following Parenteral Administration of Promethazine Promethazine is a commonly used medication to treat nausea and motion sickness. Case reports have recently surfaced on the dangers of parenteral administration of promethazine. We present a case report of a presumed intravenous injection of promethazine into an antecubital intravenous line resulting in necrosis of the ring finger distal to the DIP joint (...) -arterial or perivascular extravasation, the staggering medical malpractice awards in such cases, and the numerous therapeutic alternatives to promethazine, the medical community should question the safety and continued administration of promethazine by an intravenous route.

2012 HSS Journal

43. Low dosage promethazine and loratadine negatively affect neuromotor function. (Abstract)

Low dosage promethazine and loratadine negatively affect neuromotor function. Determine how the sedating antihistamine promethazine and non-sedating antihistamine loratadine at a dose of 10mg influence voluntary and involuntary motor processes in the hours following ingestion and the morning after ingestion.Eight healthy young adults were recruited into a human double-blind, placebo-controlled, three-way crossover study. Neuromotor function was examined using a battery of controlled reaction (...) time, postural tremor, and heart rate variability measures. Neuromotor function was assessed 4 times for each of the promethazine, loratadine and placebo interventions; pre-ingestion, 1h post-ingestion, 2h post-ingestion, and the following day.Self-perceived levels of drowsiness increased only after ingestion of promethazine. However, both antihistamines had negative effects on simple reaction time, choice reaction time, the RMS and peak power amplitude of postural tremor, and autonomic cardiac

2012 Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Controlled trial quality: uncertain

44. Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers. Full Text available with Trip Pro

Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers. Since most first-generation antihistamines have undesirable sedative effects on the central nervous systems (CNS), newer (second-generation) antihistamines have been developed to improve patients' quality of life. However, there are few reports that directly compare (...) the antihistaminic efficacy and impairment of psychomotor functions. We designed a double-blind, placebo controlled, crossover study to concurrently compare the clinical effectiveness of promethazine, a first-generation antihistamine, and fexofenadine and olopatadine, second-generation antihistamines, by measuring their potency as peripheral inhibitors of histamine-induced wheal and flare. Further, we investigated their sedative effects on the CNS using a battery of psychomotor tests. When single therapeutic

2012 Archives of dermatological research Controlled trial quality: uncertain

45. The action of promethazine (phenergan) in protecting mice against death due to histamine Full Text available with Trip Pro

The action of promethazine (phenergan) in protecting mice against death due to histamine 14801458 2004 02 15 2018 12 01 0366-0826 5 4 1950 Dec British journal of pharmacology and chemotherapy Br J Pharmacol Chemother The action of promethazine (phenergan) in protecting mice against death due to histamine. 510-6 HALPERN B N BN WOOD D R DR eng Journal Article England Br J Pharmacol Chemother 0154627 0366-0826 0 Histamine Antagonists 0 Protective Agents 820484N8I3 Histamine FF28EJQ494 Promethazine (...) OM Adrenalectomy Animals Death Histamine Histamine Antagonists Mice Promethazine Protective Agents 5120:32529:15:441:442 ADRENALECTOMY HISTAMINE HISTAMINE ANTAGONISTS 1950 12 1 1950 12 1 0 1 1950 12 1 0 0 ppublish 14801458 PMC1509989 Arch Int Pharmacodyn Ther. 1950 May 1;82(3):247-96 15419873 Arch Int Pharmacodyn Ther. 1950 May 15;82(4):425-76 15419885 J Physiol. 1922 Dec 22;57(1-2):82-99 16993603

1950 British journal of pharmacology and chemotherapy

46. The Pharmacology of Chlorpromazine and Promethazine Full Text available with Trip Pro

The Pharmacology of Chlorpromazine and Promethazine 13194639 2003 05 01 2018 12 01 0035-9157 47 8 1954 Aug Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. The pharmacology of chlorpromazine and promethazine. 617-21 BURN J H JH eng Journal Article England Proc R Soc Med 7505890 0035-9157 0 Anti-Allergic Agents 0 Histamine H1 Antagonists FF28EJQ494 Promethazine U42B7VYA4P Chlorpromazine OM Anti-Allergic Agents Chlorpromazine Histamine H1 Antagonists Promethazine 5527:6219:39:108

1954 Proceedings of the Royal Society of Medicine

47. Combination of Chlorpromazine, Promethazine, and Pethidine in Treatment of Eclampsia Full Text available with Trip Pro

Combination of Chlorpromazine, Promethazine, and Pethidine in Treatment of Eclampsia 13436860 2002 05 01 2018 12 01 0007-1447 2 5036 1957 Jul 13 British medical journal Br Med J Combination of chlorpromazine, promethazine, and pethidine in treatment of eclampsia. 75-8 SHEARES B H BH eng Journal Article England Br Med J 0372673 0007-1447 0 Anti-Allergic Agents 0 Histamine H1 Antagonists 9E338QE28F Meperidine FF28EJQ494 Promethazine U42B7VYA4P Chlorpromazine OM Anti-Allergic Agents Chlorpromazine (...) therapeutic use Eclampsia therapy Female Histamine H1 Antagonists therapeutic use Meperidine therapeutic use Pregnancy Promethazine 5732:35121 ANTIHISTAMINICS/therapeutic use CHLORPROMAZINE/therapeutic use ECLAMPSIA/therapy MEPERIDINE/therapeutic use 1957 7 13 1957 7 13 0 1 1957 7 13 0 0 ppublish 13436860 PMC1961749 Arch Int Pharmacodyn Ther. 1953 Jan;92(3-4):305-61 13041303 J Obstet Gynaecol Br Emp. 1956 Apr;63(2):255-9 13320228 C R Seances Soc Biol Fil. 1952 Apr;146(7-8):561-4 12998158

1957 British medical journal

48. Action of Promethazine on Systemic Blood Pressure, Pulmonary Artery Pressure, and Pulmonary Blood-flow Full Text available with Trip Pro

Action of Promethazine on Systemic Blood Pressure, Pulmonary Artery Pressure, and Pulmonary Blood-flow 13209095 2003 05 01 2018 12 01 0007-1447 2 4899 1954 Nov 27 British medical journal Br Med J Action of promethazine on systemic blood pressure, pulmonary artery pressure and pulmonary bloodflow. 1266-7 HOWARTH S S OWEN S G SG eng Journal Article England Br Med J 0372673 0007-1447 0 Histamine H1 Antagonists FF28EJQ494 Promethazine OM Arteries Blood Circulation Blood Pressure drug effects Blood (...) Pressure Determination Cardiovascular System Hemodynamics Histamine H1 Antagonists pharmacology Humans Promethazine Pulmonary Artery drug effects 5527:20871:39:47:71:74 ANTIHISTAMINICS/effects ARTERIES, PULMONARY/effect of drugs on BLOOD CIRCULATION BLOOD PRESSURE/effect of drugs on 1954 11 27 1954 11 27 0 1 1954 11 27 0 0 ppublish 13209095 PMC2080061 J Pharmacol Exp Ther. 1953 Jul;108(3):340-8 13070153 Proc R Soc Med. 1954 Jun;47(6):407-10 13177541

1954 British medical journal

49. Comparison of some pharmacological properties of chlorpromazine, promethazine and pethidine Full Text available with Trip Pro

Comparison of some pharmacological properties of chlorpromazine, promethazine and pethidine 13219260 2003 05 01 2018 12 01 0366-0826 9 4 1954 Dec British journal of pharmacology and chemotherapy Br J Pharmacol Chemother Comparison of some pharmacological properties of chlorpromazine, promethazine, and pethidine. 392-401 KOPERA J J ARMITAGE A K AK eng Journal Article England Br J Pharmacol Chemother 0154627 0366-0826 0 Anti-Allergic Agents 0 Histamine H1 Antagonists 9E338QE28F Meperidine (...) FF28EJQ494 Promethazine U42B7VYA4P Chlorpromazine OM Anti-Allergic Agents Chlorpromazine Histamine H1 Antagonists Meperidine Promethazine 5527:31189:39:108:289 ANTIHISTAMINICS CHLORPROMAZINE MEPERIDINE 1954 12 1 1954 12 1 0 1 1954 12 1 0 0 ppublish 13219260 PMC1509448 Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1954;222(1-2):75-6 13176453 Br Med J. 1953 Dec 5;2(4848):1247-8 13106396 Mem Acad Chir (Paris). 1953 May 20-27;79(17-18):414-22 13086607 Presse Med. 1951 Oct 13;59(64):1329 14891672 Naunyn

1954 British journal of pharmacology and chemotherapy

50. The Use of Promethazine for Premedication Full Text available with Trip Pro

The Use of Promethazine for Premedication 19598755 2009 07 30 2018 11 13 5 5 1958 May Journal of the American Dental Society of Anesthesiology J Am Dent Soc Anesthesiol The Use of Promethazine for Premedication. 12-8 Stuebner E A EA Sadove M M eng Journal Article United States J Am Dent Soc Anesthesiol 7505572 2009 7 15 9 0 1958 5 1 0 0 1958 5 1 0 1 ppublish 19598755 PMC2067285 Br Med J. 1954 Nov 27;2(4899):1266-7 13209095

1958 Journal of the American Dental Society of Anesthesiology

51. The Use of Promethazine (Phenergan) as a Sedative During Labour Full Text available with Trip Pro

The Use of Promethazine (Phenergan) as a Sedative During Labour 13596915 2000 07 01 2018 12 01 0008-4409 79 10 1958 Nov 15 Canadian Medical Association journal Can Med Assoc J The use of promethazine (phenergan) as a sedative during labour. 822-5 HOBBS F S FS CARROLL J J JJ eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Hypnotics and Sedatives FF28EJQ494 Promethazine OM Analgesia Anesthesia Anesthesia and Analgesia Female Humans Hypnotics and Sedatives Labor, Obstetric Pain (...) Management Pregnancy Promethazine therapeutic use 5935:26423:320:478 LABOR/anesthesia and analgesia PROMETHAZINE/therapeutic use 1958 11 15 1958 11 15 0 1 1958 11 15 0 0 ppublish 13596915 PMC1830480 C R Seances Soc Biol Fil. 1951 Mar;145(5-6):353-6 14849058 J Nerv Ment Dis. 1956 Jul;124(1):53-7 13416920 Am Pract Dig Treat. 1957 Oct;8(10):1571-5 13470290

1958 Canadian Medical Association Journal

52. Promethazine, an Adjunct to Preoperative Medication Full Text available with Trip Pro

Promethazine, an Adjunct to Preoperative Medication 13373271 2002 05 01 2018 12 01 0003-4932 144 5 1956 Nov Annals of surgery Ann. Surg. Promethazine, an adjunct to preoperative medication. 861-4 MCGEE J P JP Jr WEISS W A WA eng Journal Article United States Ann Surg 0372354 0003-4932 0 Histamine H1 Antagonists FF28EJQ494 Promethazine OM Anesthesia Anesthesiology Histamine H1 Antagonists therapeutic use Humans Promethazine 5731:19558 ANESTHESIA ANTIHISTAMINICS/therapeutic use 1956 11 1 1956 11

1956 Annals of Surgery

53. [Psychologic-experimental studies on the effects of propiramfumarate and promethazine under normal-and stress conditions]. (Abstract)

[Psychologic-experimental studies on the effects of propiramfumarate and promethazine under normal-and stress conditions]. 4599961 1974 08 19 2013 11 21 0004-4172 24 4 1974 Apr Arzneimittel-Forschung Arzneimittelforschung [Psychologic-experimental studies on the effects of propiramfumarate and promethazine under normal-and stress conditions]. 675-93 Boucsein W W Janke W W ger Clinical Trial Comparative Study Controlled Clinical Trial English Abstract Journal Article Randomized Controlled Trial (...) Experimentalpsychologische Untersuchungen zur Wirkung von Propiramfumarat und Promethazin unter Normal- und Stressbedingungen Germany Arzneimittelforschung 0372660 0004-4172 0 Amides 0 Analgesics 0 Fumarates 0 Piperidines 0 Placebos 0 Propionates 0 Pyridines FF28EJQ494 Promethazine IM Administration, Oral Amides pharmacology Analgesics pharmacology Clinical Trials as Topic Fumarates pharmacology Humans Male Mental Processes drug effects Noise Piperidines pharmacology Placebos Promethazine pharmacology Propionates

1974 Arzneimittel-Forschung Controlled trial quality: uncertain

54. The suppression of rejection of Nippostrongylus brasiliensis in the rat by promethazine hydrochloride: The site of immunological impairment Full Text available with Trip Pro

The suppression of rejection of Nippostrongylus brasiliensis in the rat by promethazine hydrochloride: The site of immunological impairment 5026852 1972 07 25 2018 11 30 0019-2805 22 3 1972 Mar Immunology Immunology The suppression of rejection of Nippostrongylus brasiliensis in the rat by promethazine hydrochloride. The site of immunological impairment. 361-70 Kelly J D JD Dineen J K JK eng Journal Article England Immunology 0374672 0019-2805 0 Antigens 0 Biogenic Amines 0 Immune Sera (...) FF28EJQ494 Promethazine IM Animals Antigens Biogenic Amines metabolism Feces Hookworm Infections immunology Immune Sera Immunity drug effects Immunization Injections, Intravenous Intestine, Small Lymph Nodes cytology Lymphocyte Transfusion Lymphocytes drug effects Male Parasite Egg Count Promethazine pharmacology Rats Transplantation, Homologous 1972 3 1 1972 3 1 0 1 1972 3 1 0 0 ppublish 5026852 PMC1407783 Immunology. 1972 Feb;22(2):199-210 5062015 Arch Int Pharmacodyn Ther. 1956 Jul 1;107(1):62-74

1972 Immunology

55. Selective inhibition of Bacillus subtilis sporulation by acridine orange and promethazine. Full Text available with Trip Pro

Selective inhibition of Bacillus subtilis sporulation by acridine orange and promethazine. Two structurally similar compounds were found to inhibit sporulation in Bacillus subtilis 168. A dye, acridine orange, and an antischizophrenic drug, promethazine, blocked spore formation at concentrations subinhibitory to vegetative growth, while allowing synthesis of serine protease, antibiotic, and certain catabolite-repressed enzymes. The sporulation process was sensitive to promethazine through T2

1977 Journal of bacteriology

56. Effects of Promethazine-Hydrochloride on Human Polymorphonuclear Leukocytes Full Text available with Trip Pro

Effects of Promethazine-Hydrochloride on Human Polymorphonuclear Leukocytes Promethazine hydrochloride at a concentration of 0.033 mg/ml has pronounced effects on leukocyte metabolism and function. The drug inhibits the phagocytosis-induced increases in O(2) consumption and hexose monophosphate shunt activity. Associated with these effects is an inhibition of the iodination of zymosan particles and an inhibition of bacterial killing by the cell. At least two mechanisms appear to be involved (...) . Many of the effects can be explained by an inhibition of phagocytosis, but promethazine also inhibits the decarboxylation of amino acids and iodide fixation in a cell-free system, indicating a specific effect on metabolism. These results may partially account for the action of the drug in ameliorating the effects of erythroblastosis.

1973 Infection and immunity

57. Prevention of postoperative intestinal adhesions with combined promethazine and dexamethasone therapy: experimental and clinical studies. Full Text available with Trip Pro

Prevention of postoperative intestinal adhesions with combined promethazine and dexamethasone therapy: experimental and clinical studies. 5935011 1966 08 12 2018 11 13 0003-4932 163 4 1966 Apr Annals of surgery Ann. Surg. Prevention of postoperative intestinal adhesions with combined promethazine and dexamethasone therapy: experimental and clinical studies. 580-8 Replogle R L RL Johnson R R Gross R E RE eng Journal Article United States Ann Surg 0372354 0003-4932 7S5I7G3JQL Dexamethasone (...) FF28EJQ494 Promethazine AIM IM J Adult Animals Child, Preschool Dexamethasone therapeutic use Humans Infant Postoperative Complications prevention & control Promethazine therapeutic use Rats Tissue Adhesions prevention & control 660736 00076853 This study, combining experimental and clinical data, attempted to develop methods to prevent formation of adhesions in the highly susceptible infant undergoing abdominal surgery and to inhibit reformation of adhesions after surgical division of those which had

1966 Annals of Surgery

58. Promethazine poisoning: clinical and electroencephalographic observations. Full Text available with Trip Pro

Promethazine poisoning: clinical and electroencephalographic observations. 6020998 1967 05 19 2018 11 13 0007-1447 2 5543 1967 Apr 01 British medical journal Br Med J Promethazine poisoning: clinical and electroencephalographic observations. 31-2 Leak D D Carroll D D eng Case Reports Journal Article England Br Med J 0372673 0007-1447 FF28EJQ494 Promethazine AIM IM Child Electroencephalography Humans Male Promethazine poisoning 1967 4 1 1967 4 1 0 1 1967 4 1 0 0 ppublish 6020998 PMC1841111 Rev

1967 British medical journal

59. The effects of carbon tetrachloride on rat liver microsomes during the first hour of poisoning in vivo, and the modifying actions of promethazine Full Text available with Trip Pro

The effects of carbon tetrachloride on rat liver microsomes during the first hour of poisoning in vivo, and the modifying actions of promethazine The effects of an oral administration of carbon tetrachloride on various liver microsomal and supernatant components were studied 1hr. and 2hr. after dosing. The modifications of such early changes resulting from a concomitant administration of promethazine together with the carbon tetrachloride were also investigated. The microsomal components (...) solution. The RNA phosphorus redistribution, the decrease in inorganic pyrophosphatase and the increases in neotetrazolium reductase activities were at least partially prevented by a concomitant dosing with promethazine. However, the decrease in cytochrome P-450 was not affected by promethazine treatment. These early changes are discussed in terms of the liver necrosis produced by carbon tetrachloride and which is greatly retarded in its onset by the administration of promethazine.

1969 Biochemical Journal

60. The Use of Promethazine as a Local Anæsthetic Full Text available with Trip Pro

The Use of Promethazine as a Local Anæsthetic 14404210 1998 11 01 2018 12 01 0008-4409 82 1960 Apr 16 Canadian Medical Association journal Can Med Assoc J The use of promethazine as a local anaesthetic. 833-4 KALZ F F FEKETE Z Z eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Anesthetics, Local FF28EJQ494 Promethazine OM Analgesia Anesthesia Anesthesia and Analgesia Anesthesia, Local Anesthetics, Local Pain Management Promethazine PROMETHAZINE/anesthesia and analgesia 1960 4 16

1960 Canadian Medical Association Journal

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>