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Promethazine

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41. Ionophore-Based Potentiometric Sensors for the Flow-Injection Determination of Promethazine Hydrochloride in Pharmaceutical Formulations and Human Urine (PubMed)

Ionophore-Based Potentiometric Sensors for the Flow-Injection Determination of Promethazine Hydrochloride in Pharmaceutical Formulations and Human Urine Plasticised poly(vinyl chloride)-based membranes containing the ionophores (α-, β- and γ-cyclodextrins (CD), dibenzo-18-crown-6 (DB18C6) and dibenzo-30-crown-10 (DB30C10) were evaluated for their potentiometric response towards promethazine (PM) in a flow injection analysis (FIA) set-up. Good responses were obtained when β- and γ-CDs

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2011 Sensors (Basel, Switzerland)

42. Preanesthetic sedation of preschool children: Comparison of intranasal midazolam versus oral promethazine (PubMed)

Preanesthetic sedation of preschool children: Comparison of intranasal midazolam versus oral promethazine Ensuring adequate preoperative sedation and anxiolysis is essential, especially in pediatric surgery. Various drugs and routes of administration have been evaluated to determine the optimal method of sedation.We selected hundred preschool children undergoing elective surgery and sedated them with either intranasal midazolam or oral promethazine syrup in the preoperative period. They were

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2011 Anesthesia, essays and researches

43. Portable system of programmable syringe pump with potentiometer for determination of promethazine in pharmaceutical applications (PubMed)

Portable system of programmable syringe pump with potentiometer for determination of promethazine in pharmaceutical applications A simple and fast-automated method was developed and validated for the assay of promethazine hydrochloride in pharmaceutical formulations, based on the oxidation of promethazine by cerium in an acidic medium. A portable system, consisting of a programmable syringe pump connected to a potentiometer, was constructed. The developed change in potential during promethazine

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2011 Saudi Pharmaceutical Journal : SPJ

44. A randomized, placebo-controlled trial of ondansetron, metoclopramide, and promethazine in adults. (PubMed)

A randomized, placebo-controlled trial of ondansetron, metoclopramide, and promethazine in adults. The objective of the study was to assess whether ondansetron has superior nausea reduction compared with metoclopramide, promethazine, or saline placebo in emergency department (ED) adults.This randomized, placebo-controlled, double-blinded superiority trial was intended to enroll a convenience sample of 600 patients. Nausea was evaluated on a 100-mm visual analog scale (VAS) at baseline and 30 (...) minutes after treatment. Patients with a minimum preenrollment VAS of 40 mm were randomized to intravenous ondansetron 4 mg, metoclopramide 10 mg, promethazine 12.5 mg, or saline placebo. A 12-mm VAS improvement in nausea severity was deemed clinically important. We measured potential drug adverse effects at baseline and 30 minutes. Patients received approximately 500 mL of saline hydration during the initial 30 minutes.Of 180 subjects who consented, 163 completed the study. The median age was 32

2011 American Journal of Emergency Medicine

45. Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial. (PubMed)

Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial. Envenoming from snakebites is most effectively treated by antivenom. However, the antivenom available in South Asian countries commonly causes acute allergic reactions, anaphylactic reactions being particularly serious. We investigated whether adrenaline, promethazine, and hydrocortisone prevent such reactions (...) in secondary referral hospitals in Sri Lanka by conducting a randomised, double-blind placebo-controlled trial.In total, 1,007 patients were randomized, using a 2 × 2 × 2 factorial design, in a double-blind, placebo-controlled trial of adrenaline (0.25 ml of a 1∶1,000 solution subcutaneously), promethazine (25 mg intravenously), and hydrocortisone (200 mg intravenously), each alone and in all possible combinations. The interventions, or matching placebo, were given immediately before infusion of antivenom

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2011 PLoS medicine

46. Rapid tranquilization for agitated patients in emergency psychiatric rooms: a randomized trial of olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol alone. (PubMed)

Rapid tranquilization for agitated patients in emergency psychiatric rooms: a randomized trial of olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol alone. To compare the effectiveness of intramuscular olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol alone as the first medication(s) used to treat patients with agitation and aggressive behavior.One hundred fifty patients with agitation caused (...) by psychotic or bipolar disorder were randomly assigned under double-blind conditions to receive olanzapine, ziprasidone, haloperidol plus midazolam, haloperidol plus promethazine or haloperidol alone. The Overt Agitation Severity Scale, Overt Aggression Scale and Ramsay Sedation Scale were applied within 12 hours after the first dosage.All medications produced a calming effect within one hour of administration, but only olanzapine and haloperidol reduced agitation by less than 10 points, and only

2011 Revista brasileira de psiquiatria (São Paulo, Brazil : 1999)

47. Comparison of parenteral promethazine versus midazolam effect as a preoperative medication on postoperative nausea and vomiting after appendectomy. (PubMed)

Comparison of parenteral promethazine versus midazolam effect as a preoperative medication on postoperative nausea and vomiting after appendectomy. Postoperative nausea and vomiting is a high unpleasant symptom in surgical procedures. This study compares the effectiveness of midazolam with promethazine as multipurpose drug in postoperative nausea and vomiting as a preoperative and anesthetic medication after appendectomy. Methods : This randomized, double - blind clinical trial study (...) was performed in patients who underwent appendectomy. These patients randomly received either placebo or midazolam or promethazine 5 minutes before appendectomy. All episodes of vomiting and nausea within 24 hours after surgery were recorded. The study population (N=75) comprised 3 comparable subgroups (N=25 in each group). A standard general anesthetic technique and postoperative analgesia were used. The data were collected and analyzed.Vomiting and nausea occurred in 19.20%, 0% and 81.80% of the patients

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2011 Caspian journal of internal medicine

48. Fixed drug eruption caused by three unrelated drugs: promethazine, pethidine and omeprazole. (PubMed)

Fixed drug eruption caused by three unrelated drugs: promethazine, pethidine and omeprazole. We report a case of fixed drug eruption (FDE) caused by three unrelated drugs. A 52-year-old woman presented with a diagnosis of FDE after taking a drug to treat a common cold. An oral provocation test and a patch test were carried out, and the patient reacted to promethazine, which is a derivative of phenothiazine. To determine the core structure of the antigen, we performed patch testing (...) and/or an oral provocation testing with six drugs that are similar in structure to promethazine. The patient reacted to five of the six drugs, and the antigenic determinant was identified as a phenothiazine and a tricyclic structure. The patient had similar eruptions at the same sites 3 years later after taking pethidine. Seven months after that reaction, a more severe eruption was caused by oral omeprazole. This is an extremely rare case of FDE caused by three structurally unrelated drugs.© The Author(s

2011 Clinical & Experimental Dermatology

49. [Psychologic-experimental studies on the effects of propiramfumarate and promethazine under normal-and stress conditions]. (PubMed)

[Psychologic-experimental studies on the effects of propiramfumarate and promethazine under normal-and stress conditions]. 4599961 1974 08 19 2013 11 21 0004-4172 24 4 1974 Apr Arzneimittel-Forschung Arzneimittelforschung [Psychologic-experimental studies on the effects of propiramfumarate and promethazine under normal-and stress conditions]. 675-93 Boucsein W W Janke W W ger Clinical Trial Comparative Study Controlled Clinical Trial English Abstract Journal Article Randomized Controlled Trial (...) Experimentalpsychologische Untersuchungen zur Wirkung von Propiramfumarat und Promethazin unter Normal- und Stressbedingungen Germany Arzneimittelforschung 0372660 0004-4172 0 Amides 0 Analgesics 0 Fumarates 0 Piperidines 0 Placebos 0 Propionates 0 Pyridines FF28EJQ494 Promethazine IM Administration, Oral Amides pharmacology Analgesics pharmacology Clinical Trials as Topic Fumarates pharmacology Humans Male Mental Processes drug effects Noise Piperidines pharmacology Placebos Promethazine pharmacology Propionates

1974 Arzneimittel-Forschung

50. Prevention of postoperative intestinal adhesions with combined promethazine and dexamethasone therapy: experimental and clinical studies. (PubMed)

Prevention of postoperative intestinal adhesions with combined promethazine and dexamethasone therapy: experimental and clinical studies. 5935011 1966 08 12 2018 11 13 0003-4932 163 4 1966 Apr Annals of surgery Ann. Surg. Prevention of postoperative intestinal adhesions with combined promethazine and dexamethasone therapy: experimental and clinical studies. 580-8 Replogle R L RL Johnson R R Gross R E RE eng Journal Article United States Ann Surg 0372354 0003-4932 7S5I7G3JQL Dexamethasone (...) FF28EJQ494 Promethazine AIM IM J Adult Animals Child, Preschool Dexamethasone therapeutic use Humans Infant Postoperative Complications prevention & control Promethazine therapeutic use Rats Tissue Adhesions prevention & control 660736 00076853 This study, combining experimental and clinical data, attempted to develop methods to prevent formation of adhesions in the highly susceptible infant undergoing abdominal surgery and to inhibit reformation of adhesions after surgical division of those which had

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1966 Annals of Surgery

51. Promethazine poisoning: clinical and electroencephalographic observations. (PubMed)

Promethazine poisoning: clinical and electroencephalographic observations. 6020998 1967 05 19 2018 11 13 0007-1447 2 5543 1967 Apr 01 British medical journal Br Med J Promethazine poisoning: clinical and electroencephalographic observations. 31-2 Leak D D Carroll D D eng Case Reports Journal Article England Br Med J 0372673 0007-1447 FF28EJQ494 Promethazine AIM IM Child Electroencephalography Humans Male Promethazine poisoning 1967 4 1 1967 4 1 0 1 1967 4 1 0 0 ppublish 6020998 PMC1841111 Rev

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1967 British medical journal

52. Selective inhibition of Bacillus subtilis sporulation by acridine orange and promethazine. (PubMed)

Selective inhibition of Bacillus subtilis sporulation by acridine orange and promethazine. Two structurally similar compounds were found to inhibit sporulation in Bacillus subtilis 168. A dye, acridine orange, and an antischizophrenic drug, promethazine, blocked spore formation at concentrations subinhibitory to vegetative growth, while allowing synthesis of serine protease, antibiotic, and certain catabolite-repressed enzymes. The sporulation process was sensitive to promethazine through T2

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1977 Journal of bacteriology

53. Comparison of some pharmacological properties of chlorpromazine, promethazine and pethidine (PubMed)

Comparison of some pharmacological properties of chlorpromazine, promethazine and pethidine 13219260 2003 05 01 2018 12 01 0366-0826 9 4 1954 Dec British journal of pharmacology and chemotherapy Br J Pharmacol Chemother Comparison of some pharmacological properties of chlorpromazine, promethazine, and pethidine. 392-401 KOPERA J J ARMITAGE A K AK eng Journal Article England Br J Pharmacol Chemother 0154627 0366-0826 0 Anti-Allergic Agents 0 Histamine H1 Antagonists 9E338QE28F Meperidine (...) FF28EJQ494 Promethazine U42B7VYA4P Chlorpromazine OM Anti-Allergic Agents Chlorpromazine Histamine H1 Antagonists Meperidine Promethazine 5527:31189:39:108:289 ANTIHISTAMINICS CHLORPROMAZINE MEPERIDINE 1954 12 1 1954 12 1 0 1 1954 12 1 0 0 ppublish 13219260 PMC1509448 Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1954;222(1-2):75-6 13176453 Br Med J. 1953 Dec 5;2(4848):1247-8 13106396 Mem Acad Chir (Paris). 1953 May 20-27;79(17-18):414-22 13086607 Presse Med. 1951 Oct 13;59(64):1329 14891672 Naunyn

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1954 British journal of pharmacology and chemotherapy

54. The Pharmacology of Chlorpromazine and Promethazine (PubMed)

The Pharmacology of Chlorpromazine and Promethazine 13194639 2003 05 01 2018 12 01 0035-9157 47 8 1954 Aug Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. The pharmacology of chlorpromazine and promethazine. 617-21 BURN J H JH eng Journal Article England Proc R Soc Med 7505890 0035-9157 0 Anti-Allergic Agents 0 Histamine H1 Antagonists FF28EJQ494 Promethazine U42B7VYA4P Chlorpromazine OM Anti-Allergic Agents Chlorpromazine Histamine H1 Antagonists Promethazine 5527:6219:39:108

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1954 Proceedings of the Royal Society of Medicine

55. The action of promethazine (phenergan) in protecting mice against death due to histamine (PubMed)

The action of promethazine (phenergan) in protecting mice against death due to histamine 14801458 2004 02 15 2018 12 01 0366-0826 5 4 1950 Dec British journal of pharmacology and chemotherapy Br J Pharmacol Chemother The action of promethazine (phenergan) in protecting mice against death due to histamine. 510-6 HALPERN B N BN WOOD D R DR eng Journal Article England Br J Pharmacol Chemother 0154627 0366-0826 0 Histamine Antagonists 0 Protective Agents 820484N8I3 Histamine FF28EJQ494 Promethazine (...) OM Adrenalectomy Animals Death Histamine Histamine Antagonists Mice Promethazine Protective Agents 5120:32529:15:441:442 ADRENALECTOMY HISTAMINE HISTAMINE ANTAGONISTS 1950 12 1 1950 12 1 0 1 1950 12 1 0 0 ppublish 14801458 PMC1509989 Arch Int Pharmacodyn Ther. 1950 May 1;82(3):247-96 15419873 Arch Int Pharmacodyn Ther. 1950 May 15;82(4):425-76 15419885 J Physiol. 1922 Dec 22;57(1-2):82-99 16993603

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1950 British journal of pharmacology and chemotherapy

56. Action of Promethazine on Systemic Blood Pressure, Pulmonary Artery Pressure, and Pulmonary Blood-flow (PubMed)

Action of Promethazine on Systemic Blood Pressure, Pulmonary Artery Pressure, and Pulmonary Blood-flow 13209095 2003 05 01 2018 12 01 0007-1447 2 4899 1954 Nov 27 British medical journal Br Med J Action of promethazine on systemic blood pressure, pulmonary artery pressure and pulmonary bloodflow. 1266-7 HOWARTH S S OWEN S G SG eng Journal Article England Br Med J 0372673 0007-1447 0 Histamine H1 Antagonists FF28EJQ494 Promethazine OM Arteries Blood Circulation Blood Pressure drug effects Blood (...) Pressure Determination Cardiovascular System Hemodynamics Histamine H1 Antagonists pharmacology Humans Promethazine Pulmonary Artery drug effects 5527:20871:39:47:71:74 ANTIHISTAMINICS/effects ARTERIES, PULMONARY/effect of drugs on BLOOD CIRCULATION BLOOD PRESSURE/effect of drugs on 1954 11 27 1954 11 27 0 1 1954 11 27 0 0 ppublish 13209095 PMC2080061 J Pharmacol Exp Ther. 1953 Jul;108(3):340-8 13070153 Proc R Soc Med. 1954 Jun;47(6):407-10 13177541

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1954 British medical journal

57. Combination of Chlorpromazine, Promethazine, and Pethidine in Treatment of Eclampsia (PubMed)

Combination of Chlorpromazine, Promethazine, and Pethidine in Treatment of Eclampsia 13436860 2002 05 01 2018 12 01 0007-1447 2 5036 1957 Jul 13 British medical journal Br Med J Combination of chlorpromazine, promethazine, and pethidine in treatment of eclampsia. 75-8 SHEARES B H BH eng Journal Article England Br Med J 0372673 0007-1447 0 Anti-Allergic Agents 0 Histamine H1 Antagonists 9E338QE28F Meperidine FF28EJQ494 Promethazine U42B7VYA4P Chlorpromazine OM Anti-Allergic Agents Chlorpromazine (...) therapeutic use Eclampsia therapy Female Histamine H1 Antagonists therapeutic use Meperidine therapeutic use Pregnancy Promethazine 5732:35121 ANTIHISTAMINICS/therapeutic use CHLORPROMAZINE/therapeutic use ECLAMPSIA/therapy MEPERIDINE/therapeutic use 1957 7 13 1957 7 13 0 1 1957 7 13 0 0 ppublish 13436860 PMC1961749 Arch Int Pharmacodyn Ther. 1953 Jan;92(3-4):305-61 13041303 J Obstet Gynaecol Br Emp. 1956 Apr;63(2):255-9 13320228 C R Seances Soc Biol Fil. 1952 Apr;146(7-8):561-4 12998158

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1957 British medical journal

58. Promethazine, an Adjunct to Preoperative Medication (PubMed)

Promethazine, an Adjunct to Preoperative Medication 13373271 2002 05 01 2018 12 01 0003-4932 144 5 1956 Nov Annals of surgery Ann. Surg. Promethazine, an adjunct to preoperative medication. 861-4 MCGEE J P JP Jr WEISS W A WA eng Journal Article United States Ann Surg 0372354 0003-4932 0 Histamine H1 Antagonists FF28EJQ494 Promethazine OM Anesthesia Anesthesiology Histamine H1 Antagonists therapeutic use Humans Promethazine 5731:19558 ANESTHESIA ANTIHISTAMINICS/therapeutic use 1956 11 1 1956 11

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1956 Annals of Surgery

59. Photosensitivity Caused by Promethazine (PubMed)

Photosensitivity Caused by Promethazine 14426802 1998 11 01 2018 12 01 0007-1447 2 5195 1960 Jul 30 British medical journal Br Med J Photosensitivity caused by promethazine. 359-60 NEWILL R G RG eng Journal Article England Br Med J 0372673 0007-1447 FF28EJQ494 Promethazine OM Dermatitis, Phototoxic Humans Photosensitivity Disorders etiology Promethazine toxicity PHOTOSENSITIZATION/etiology PROMETHAZINE/toxicology 1960 7 30 1960 7 30 0 1 1960 7 30 0 0 ppublish 14426802 PMC2097502 Br J Dermatol

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1960 British medical journal

60. A Promethazine-Ephedrine Combination for Relief of Respiratory Allergies (PubMed)

A Promethazine-Ephedrine Combination for Relief of Respiratory Allergies 13795911 1998 11 01 2018 12 01 0008-4409 81 1959 Dec 01 Canadian Medical Association journal Can Med Assoc J A promethazine-ephedrine combination for relief of respiratory allergies. 932-3 BAIRD K A KA eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 FF28EJQ494 Promethazine GN83C131XS Ephedrine OM Disease Ephedrine therapy Humans Hypersensitivity therapy Immune System Diseases Promethazine therapy Respiration (...) Disorders Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases ALLERGY/therapy EPHEDRINE/therapy PROMETHAZINE/therapy RESPIRATORY SYSTEM/diseases 1959 12 1 1959 12 1 0 1 1959 12 1 0 0 ppublish 13795911 PMC1831341 Ann Allergy. 1957 Sep-Oct;15(5):526 13478985

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1959 Canadian Medical Association Journal

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