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21. Effects of promethazine or dexamethasone pretreatment on mivacurium-induced histamine release in children. (PubMed)

Effects of promethazine or dexamethasone pretreatment on mivacurium-induced histamine release in children. To determine the effects of pretreatment with either promethazine or dexamethasone on mivacurium-induced histamine release in children.Eighty ASA I-II children (4-10 years of age) scheduled for tonsillectomy and/or adenoidectomy were randomly divided into 4 groups (n = 20 per group) designated as either the rocuronium, mivacurium, dexamethasone (DXM), or promethazine group. Children (...) in the DXM and promethazine groups were treated separately with intramuscular DXM 0.2 mg·kg(-1) or promethazine 0.5 mg·kg(-1) injections 60 min before operation. Radial artery blood samples were collected to quantify plasma histamine concentrations 1 min before and 1, 3, and 5 min after administration of the relaxant. Mean arterial pressure (MAP), heart rate (HR), and skin flushing were recorded at the same time.No significant decreases in plasma histamine concentrations were observed between groups

2014 Paediatric anaesthesia

22. Drowsiness and motor responses to consecutive daily doses of promethazine and loratadine. (PubMed)

Drowsiness and motor responses to consecutive daily doses of promethazine and loratadine. Limited information is available regarding sedation and motor function following repeat dosing of antihistamines. This study examined how promethazine and loratadine affect day-time drowsiness, the commencement of voluntary movement, and involuntary movement when administered on consecutive days.Ten healthy young subjects (24±5years) were recruited into a double-blind, placebo-controlled, three-way (...) crossover study. Subjects ingested either promethazine, loratadine or a placebo, and ingested the same drug 24h later. Measures of drowsiness, simple reaction time (SRT), choice reaction time (CRT), and postural tremor were obtained pre-ingestion, 1h post-ingestion and 2h post-ingestion on each day.Consecutive daily doses of promethazine and loratadine affected SRT and CRT, respectively, whereby reaction time deficits were less pronounced following the repeat dose. A reduced tremor response was also

2014 Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

23. Intravenous promethazine versus lorazepam for the treatment of peripheral vertigo in the emergency department: A double blind, randomized clinical trial of efficacy and safety. (PubMed)

Intravenous promethazine versus lorazepam for the treatment of peripheral vertigo in the emergency department: A double blind, randomized clinical trial of efficacy and safety. Vertigo imposes considerable health restrictions with significant impact on the patient's quality of life. The most effective antivertigo agent is undetermined thus far.This study was performed to assess whether promethazine has superior vertigo reduction compared with lorazepam in ED patients.In this randomized, double (...) -blind, parallel group trial 184 patients were assigned (1:1 ratio) to receive either promethazine, 25 mg intravenously, or lorazepam, 2 mg intravenously. Primary endpoint was mean change in vertigo intensity at 2 hours measured using visual analog scale (VAS). Secondary endpoints were mean change in nausea score, need for second dose of study medications, and adverse events (AEs).Promethazine was associated with significantly more reduction (46.5 mm) in vertigo than lorazepam (25.7 mm, p< 0.001

2014 Journal of vestibular research : equilibrium & orientation

24. Chloral Hydrate, Chloral Hydrate - Promethazine and Chloral Hydrate -Hydroxyzine Efficacy in Electroencephalography Sedation. (PubMed)

Chloral Hydrate, Chloral Hydrate - Promethazine and Chloral Hydrate -Hydroxyzine Efficacy in Electroencephalography Sedation. To compare efficacy and safety of chloral hydrate (CH), chloral hydrate and promethazine (CH + P) and chloral hydrate and hydroxyzine (CH + H) in electroencephalography (EEG) sedation.In a parallel single-blinded randomized clinical trial, ninety 1-7 y-old uncooperative kids who were referred to Pediatric Neurology Clinic of Shahid Sadoughi University, Yazd, Iran from (...) April through August 2012, were randomly assigned to receive 40 mg/kg of chloral hydrate or 40 mg/kg of chloral hydrate and 1 mg/kg of promethazine or 40 mg/kg of chloral hydrate and 2 mg/kg of hydroxyzine. The primary endpoint was efficacy in sufficient sedation (obtaining four Ramsay sedation score) and successful completion of EEG. Secondary endpoint was clinical adverse events.Thirty nine girls (43.3 %) and 51 boys (56.7 %) with mean age of 3.34 ± 1.47 y were assessed. Sufficient sedation

2014 Indian journal of pediatrics

25. Haloperidol plus promethazine effective for psychosis induced aggression

Haloperidol plus promethazine effective for psychosis induced aggression Haloperidol plus promethazine effective for psychosis induced aggression | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username (...) * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Haloperidol plus promethazine effective for psychosis induced aggression Article Text Therapeutics Haloperidol plus promethazine effective for psychosis induced aggression Statistics from Altmetric.com Question Question: Is haloperidol plus

2010 Evidence-Based Mental Health

26. Identification of promethazine as an amyloid-binding molecule using a fluorescence high-throughput assay and MALDI imaging mass spectrometry (PubMed)

Identification of promethazine as an amyloid-binding molecule using a fluorescence high-throughput assay and MALDI imaging mass spectrometry The identification of amyloid-binding compounds is a crucial step in the development of imaging probes and therapeutics for the detection and cure of Alzheimer's disease. Unfortunately, the process typically lags during the translation from in vitro to in vivo studies due to the impenetrable nature of the blood brain barrier (BBB). Here, we integrate (...) fluorescence assay with MALDI imaging mass spectrometry to screen known compounds and repurpose their properties to enable the second function of binding to amyloid plaques. Through this approach, we identified an antihistamine compound, promethazine, that can bind to amyloid plaques. Finally, we demonstrate that promethazine is retained in the amyloid-burdened brain compared to a normal brain and that its distribution within the brain corroborates with that of amyloid plaques.

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2013 NeuroImage : Clinical

27. Efficacy and Safety of Oral Sumatriptan Plus Oral Promethazine in Migraine Treatment

Efficacy and Safety of Oral Sumatriptan Plus Oral Promethazine in Migraine Treatment Efficacy and Safety of Oral Sumatriptan Plus Oral Promethazine in Migraine Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Efficacy and Safety of Oral Sumatriptan Plus Oral Promethazine in Migraine Treatment The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01814189 Recruitment Status : Completed First Posted : March 19, 2013 Last Update Posted : July 30, 2013 Sponsor: Shahid Beheshti University of Medical

2013 Clinical Trials

28. Promethazine vs. Lorazepam for Treatment of Vertigo

Promethazine vs. Lorazepam for Treatment of Vertigo Promethazine vs. Lorazepam for Treatment of Vertigo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Promethazine vs. Lorazepam for Treatment of Vertigo (...) of Medical Sciences Study Details Study Description Go to Brief Summary: This study was a prospective, randomized, double-blind, parallel group clinical trial designed to compare the efficacy of intravenous (IV) promethazine and lorazepam for the treatment of peripheral vertigo in Emergency Department setting. Condition or disease Intervention/treatment Phase Peripheral Vertigo. Drug: Promethazine Drug: Lorazepam Phase 3 Study Design Go to Layout table for study information Study Type : Interventional

2013 Clinical Trials

29. Promethazine Plus Sumatriptan in the Treatment of Migraine: A Randomized Clinical Trial. (PubMed)

Promethazine Plus Sumatriptan in the Treatment of Migraine: A Randomized Clinical Trial. This study was performed to evaluate the efficacy and safety of the combination of sumatriptan (50 mg) plus promethazine (SPr) (25 mg) compared with sumatriptan (50 mg) plus placebo in patients with migraine attacks.Migraine is a chronic, disabling disorder with an estimated worldwide prevalence of 10% in adults imposing substantial social and economic impact. Efficient treatment of migraine attacks could

2013 Headache

30. A comparative study of the sedative effect of oral midazolam and oral promethazine medication in lumbar puncture. (PubMed)

A comparative study of the sedative effect of oral midazolam and oral promethazine medication in lumbar puncture. Lumbar puncture (LP) essentially is a painful and stressful procedure, however indicated for diagnosis and therapeutic purposes. One way to reduce the anxiety is to administer an oral premedication. The aim of this study is to compare clinical effects of oral midazolam and oral promethazine in LP.This prospective randomized controlled clinical trial study was performed on 80 (...) children aged 2-7 years that were candidate for LP. They were divided into two randomized equal groups. First group received oral midazolam syrup 0.5 mg/kg and the other group received oral promethazine syrup 1mg/kg. Level of sedation, hemodynamic changes and any other complications were monitored every 5 minutes from 30 minutes before the start of the procedure.Midazolam group and promethazine group were similar in age, gender and weight. Midazolam had significantly shorter onset of sedation and also

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2013 Iranian journal of child neurology

31. Efficacy of Chloral Hydrate and Promethazine for Sedation during Electroencephalography in Children; a Randomised Clinical Trial. (PubMed)

Efficacy of Chloral Hydrate and Promethazine for Sedation during Electroencephalography in Children; a Randomised Clinical Trial. The purpose of this study was to compare efficacy and safety of oral chloral hydrate (CH) and promethazine (PZ) for sedation during electroencephalography (EEG) in children.In a parallel single-blinded randomized clinical trial, sixty 1-10 year old children referred to EEG Unit of Shahid Sadoughi Hospital from January 2010 to February 2011 in Yazd, Iran, were (...) evaluated. They were randomized to receive orally 70 mg/kg chloral hydrate or promethazine 1 mg/kg. The primary outcome was efficacy in adequate sedation and successful recording of EEG. Secondary outcome included clinical side effects, time from administration of the drug to adequate sedation, caregiver's satisfaction on a Likert scale, and total stay time in EEG Unit.Twenty four cases with mean age 2.9±1.9 years were evaluated. Adequate sedation (Ramsay sedation score of four) was obtained in 43.3

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2013 Iranian journal of pediatrics

32. To Compare the Effect of Dextromethorphan, Promethazine and Placebo on Nocturnal Cough in Children Aged 1-12 y with Upper Respiratory Infections: A Randomized Controlled Trial. (PubMed)

To Compare the Effect of Dextromethorphan, Promethazine and Placebo on Nocturnal Cough in Children Aged 1-12 y with Upper Respiratory Infections: A Randomized Controlled Trial. To evaluate whether promethazine and dextromethorphan reduce nocturnal cough and improve sleep quality in children aged 1-12 y with upper respiratory tract infection (URI).This randomised double-blinded placebo-controlled trial was conducted in Pediatric outpatient department of Lok Nayak Hospital, Delhi. After (...) randomization into promethazine, dextromethorphan and placebo groups, parental assessment of 120 children with URI for nocturnal cough severity (child), post-tussive vomiting (child) and sleep quality (child and parent) on the night before enrolment and after 3 d of assigned medication was measured using an internally validated indigenously prepared ordinal scale.Entire cohort improved in all the study parameters after 3 d. However, no superior benefit was noted when individual parameters were compared

2013 Indian journal of pediatrics

33. Comparison of oral Midazolam-Ketamine and Midazolam-Promethazine as sedative agents in pediatric dentistry. (PubMed)

Comparison of oral Midazolam-Ketamine and Midazolam-Promethazine as sedative agents in pediatric dentistry. Investigation was designed to evaluate the behavioral changes in children receiving dental treatment while they have been administered combination of Midazolam/Ketamine or Midazolam/Promethazine.This was a randomized double blind clinical trial with cases being selected from those uncooperative children aged 2 to 6 years from those referred for treatment under general anesthesia. Anxiety (...) circumstances, Ketamine/Midazolam combination provided sufficient sedative effect in lower doses. However, Midazolam/Promethazine combination did not produce similar results.

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2012 Dental research journal

34. Antiemetic efficacy of promethazine on xylazine-induced emesis in cats (PubMed)

Antiemetic efficacy of promethazine on xylazine-induced emesis in cats The prophylactic antiemetic effect of 3 dosages of promethazine injected into cats 1 h before administration of xylazine was compared with that of a saline solution. Prior treatment with 2 and 4 mg/kg of promethazine significantly reduced the frequency of emetic episodes. Promethazine may be used as a prophylactic antiemetic in cats treated with xylazine.

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2012 The Canadian Veterinary Journal

35. Peripheral Sympathectomy as a Novel Treatment Option for Distal Digital Necrosis Following Parenteral Administration of Promethazine (PubMed)

Peripheral Sympathectomy as a Novel Treatment Option for Distal Digital Necrosis Following Parenteral Administration of Promethazine Promethazine is a commonly used medication to treat nausea and motion sickness. Case reports have recently surfaced on the dangers of parenteral administration of promethazine. We present a case report of a presumed intravenous injection of promethazine into an antecubital intravenous line resulting in necrosis of the ring finger distal to the DIP joint (...) -arterial or perivascular extravasation, the staggering medical malpractice awards in such cases, and the numerous therapeutic alternatives to promethazine, the medical community should question the safety and continued administration of promethazine by an intravenous route.

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2012 HSS Journal

36. Promethazine

Promethazine Promethazine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Promethazine Promethazine Aka: Promethazine , Phenergan From (...) Children: 0.25 to 0.5 mg/kg PO/IM/PR q4-6 hours Maximum: 25 mg per dose VIII. Efficacy Less effective than ( ) in ER patients Sedation may delay Emergency Department discharge IX. References Johnson (1993) Harriet Lane, Mosby, p. 521 (2002) Tarascon Pocket Pharmacopoeia, p. 67 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Promethazine." Click on the image (or right click) to open the source website in a new browser window. Related

2015 FP Notebook

37. Effect of Hyoscine and Promethazine on Labor Pain

Effect of Hyoscine and Promethazine on Labor Pain Effect of Hyoscine and Promethazine on Labor Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Hyoscine and Promethazine on Labor Pain (...) Sciences Study Details Study Description Go to Brief Summary: It is always considered to shorten the duration of delivery without compromising the mother and fetus by obstetrics. Hyoscine and Promethazine are used widely in hospital and research is very limited, with conflicting results regarding the efficacy of these two drugs. So the investigators decided to compare of effect of hyoscine N-butyl bromide and Promethazine on length of active phase of the first stage of labor. Condition or disease

2012 Clinical Trials

38. Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers. (PubMed)

Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers. Since most first-generation antihistamines have undesirable sedative effects on the central nervous systems (CNS), newer (second-generation) antihistamines have been developed to improve patients' quality of life. However, there are few reports that directly compare (...) the antihistaminic efficacy and impairment of psychomotor functions. We designed a double-blind, placebo controlled, crossover study to concurrently compare the clinical effectiveness of promethazine, a first-generation antihistamine, and fexofenadine and olopatadine, second-generation antihistamines, by measuring their potency as peripheral inhibitors of histamine-induced wheal and flare. Further, we investigated their sedative effects on the CNS using a battery of psychomotor tests. When single therapeutic

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2012 Archives of dermatological research

39. Low dosage promethazine and loratadine negatively affect neuromotor function. (PubMed)

Low dosage promethazine and loratadine negatively affect neuromotor function. Determine how the sedating antihistamine promethazine and non-sedating antihistamine loratadine at a dose of 10mg influence voluntary and involuntary motor processes in the hours following ingestion and the morning after ingestion.Eight healthy young adults were recruited into a human double-blind, placebo-controlled, three-way crossover study. Neuromotor function was examined using a battery of controlled reaction (...) time, postural tremor, and heart rate variability measures. Neuromotor function was assessed 4 times for each of the promethazine, loratadine and placebo interventions; pre-ingestion, 1h post-ingestion, 2h post-ingestion, and the following day.Self-perceived levels of drowsiness increased only after ingestion of promethazine. However, both antihistamines had negative effects on simple reaction time, choice reaction time, the RMS and peak power amplitude of postural tremor, and autonomic cardiac

2012 Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

40. Comparison of Oral Midazolam and Promethazine with Oral Midazolam alone for Sedating Children during Computed Tomography. (PubMed)

Comparison of Oral Midazolam and Promethazine with Oral Midazolam alone for Sedating Children during Computed Tomography. Both midazolam and promethazine are recommended to be used as sedatives in many studies but each have some side effects that limits their use. Combination therapy as an alternative method, may decreases these limitations. Therefore, this study aimed to compare midazolam with midazolam-promethazine regarding induction, maintenance, and recovery characteristics following (...) pediatric procedural sedation and analgesia.Children under 7 years old who needed sedation for being CT scanned were included in this double-blind randomized clinical trial. The patients were randomly divided into 2 groups: one only received midazolam (0.5 mg/kg), while the other group received a combination of midazolam (0.5 mg/kg) and promethazine (1.25 mg/kg). University of Michigan Sedation Scale (UMSS) was used to assess sedation induction. In addition to demographic data, the child's vital signs

2015 Emergency (Tehran, Iran)

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